TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Furuichi, K.
A1  - Iwasaki, H.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
T1  - Technology of photocurable polymeric membranes for integrated LAPS
JF  - Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan
Y1  - 2001
N1  - Chemical sensors; 17.2001 Suppl. B; East Asian Conference on Chemical Sensors ; (5, 2001; Nagasaki)
SP  - 66
EP  - 68
PB  - Japan Association of Chemical Sensors
CY  - Kasuga, Fukuoka-ken
ER  - 
TY  - JOUR
A1  - Mourzina, Y.
A1  - Yoshinobu, T.
A1  - Ermelenko, Y.
A1  - Furuichi, K.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Technology of photocurable membranes for ion sensors based on laser scanned semiconductor transducer (LSST)
JF  - Book of abstracts / ed. by J. Saneistr.
Y1  - 2002
SN  - 80-01-02576-4
N1  - Eurosensors ; (16, 2002, Praha)
SP  - 254
EP  - 257
PB  - Czech Technical University, Faculty of Electrical Engineering, Department of Measurement
CY  - Prague
ER  - 
TY  - JOUR
A1  - Heiden, W.
A1  - Turek, M.
A1  - Schöning, Michael Josef
T1  - TasteIT : Analyzing chemical sensor data using fuzzy logic
Y1  - 2011
SN  - 978-1-4244-9910-6
N1  - 2011 IEEE Workshop on Merging Fields of Computational Intelligence and Sensor Technology ; 11.-15. April 2011 Paris, France
SP  - 1
EP  - 6
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Muschallik, Lukas
A1  - Kipp, Carina Ronja
A1  - Recker, Inga
A1  - Bongaerts, Johannes
A1  - Pohl, Martina
A1  - Gelissen, Melanie
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
A1  - Siegert, Petra
T1  - Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2, 3-diol dehydrogenase
JF  - Journal of Biotechnology
N2  - The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled.
Y1  - 2020
SN  - 2590-1559
U6  - http://dx.doi.org/10.1016/j.jbiotec.2020.09.016
VL  - 202
IS  - Vol. 324
SP  - 61
EP  - 70
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Muschallik, Lukas
A1  - Molinnus, Denise
A1  - Jablonski, Melanie
A1  - Kipp, Carina Ronja
A1  - Bongaerts, Johannes
A1  - Pohl, Martina
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
A1  - Siegert, Petra
T1  - Synthesis of α-hydroxy ketones and vicinal (R, R)-diols by Bacillus clausii DSM 8716ᵀ butanediol dehydrogenase
JF  - RSC Advances
N2  - α-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716ᵀ (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn²⁺ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated.
Y1  - 2020
U6  - http://dx.doi.org/10.1039/D0RA02066D
SN  - 2046-2069
VL  - 10
SP  - 12206
EP  - 12216
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Jessing, Max P.
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Surface regeneration and reusability of label-free DNA biosensors based on weak polyelectrolyte-modified capacitive field-effect structures
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2018.11.019
SN  - 0956-5663
VL  - 126
SP  - 510
EP  - 517
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Oberländer, Jan
A1  - Mätzkow, M.
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Surface functionalization for spore-based biosensors with organosilanes
JF  - Electrochimica Acta
N2  - In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated.
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.electacta.2017.04.157
SN  - 0013-4686
VL  - 241
SP  - 237
EP  - 243
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Beging, Stefan
A1  - Leinhos, Marcel
A1  - Jablonski, Melanie
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Studying the spatially resolved immobilisation of enzymes on a capacitive field-effect structure by means of nano-spotting
JF  - Physica status solidi (a)
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431891
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1353
EP  - 1358
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Welden, Melanie
A1  - Severins, Robin
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Siegert, Petra
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Studying the immobilization of acetoin reductase with Tobacco mosaic virus particles on capacitive field-effect sensors
T2  - 2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN)
N2  - A capacitive electrolyte-insulator-semiconductor (EISCAP) biosensor modified with Tobacco mosaic virus (TMV) particles for the detection of acetoin is presented. The enzyme acetoin reductase (AR) was immobilized on the surface of the EISCAP using TMV particles as nanoscaffolds. The study focused on the optimization of the TMV-assisted AR immobilization on the Ta 2 O 5 -gate EISCAP surface. The TMV-assisted acetoin EISCAPs were electrochemically characterized by means of leakage-current, capacitance-voltage, and constant-capacitance measurements. The TMV-modified transducer surface was studied via scanning electron microscopy.
KW  - Tobacco mosaic virus
KW  - acetoin
KW  - capacitive field-effect biosensor
KW  - enzyme immobilization
Y1  - 2022
SN  - 978-1-6654-5860-3 (Online)
SN  - 978-1-6654-5861-0 (Print)
U6  - http://dx.doi.org/10.1109/ISOEN54820.2022.9789657
N1  - IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 29 May 2022 - 01 June 2022, Aveiro, Portugal.
PB  - IEEE
ER  - 
TY  - JOUR
A1  - Oberländer, Jan
A1  - Jildeh, Zaid B.
A1  - Kirchner, Patrick
A1  - Wendeler, Luisa
A1  - Bromm, Alexander
A1  - Iken, Heiko
A1  - Wagner, Patrick
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Study of Interdigitated Electrode Arrays Using Experiments and Finite Element Models for the Evaluation of Sterilization Processes
JF  - Sensors
N2  - In this work, a sensor to evaluate sterilization processes with hydrogen peroxide vapor has been characterized. Experimental, analytical and numerical methods were applied to evaluate and study the sensor behavior. The sensor set-up is based on planar interdigitated electrodes. The interdigitated electrode structure consists of 614 electrode fingers spanning over a total sensing area of 20 mm2. Sensor measurements were conducted with and without microbiological spores as well as after an industrial sterilization protocol. The measurements were verified using an analytical expression based on a first-order elliptical integral. A model based on the finite element method with periodic boundary conditions in two dimensions was developed and utilized to validate the experimental findings.
Y1  - 2015
U6  - http://dx.doi.org/10.3390/s151026115
SN  - 1424-8220
N1  - This article belongs to the Special Issue "Gas Sensors—Designs and Applications"
VL  - 15
IS  - 10
SP  - 26115
EP  - 26127
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Simonis, A.
A1  - Lüth, H.
A1  - Wang, J.
A1  - Schöning, Michael Josef
T1  - Strategies of miniaturised reference electrodes integrated in a silicon-based „one chip“ pH sensor
JF  - Sensors. 3 (2003), H. 9
Y1  - 2003
SN  - 1424-8220
SP  - 330
EP  - 339
ER  - 
TY  - JOUR
A1  - Oberländer, Jan
A1  - Kirchner, Patrick
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Strategies in developing thin-film sensors for monitoring aseptic food processes : Theoretical considerations and investigations of passivation materials
JF  - Electrochimica Acta
N2  - The sterilization of packages in aseptic food processes is highly significant to maintain a consumer-safe product with extended shelf-life. Today, the sterilization of food packages is predominantly accomplished by gaseous hydrogen peroxide (H2O2) in combination with heat. In order to monitor this sterilization process, calorimetric gas sensors as differential set-up of two platinum temperature sensors representing a catalytically active (additionally deposition of MnO2) and a passive segment have been recently developed. The temperature rise of the exothermic decomposition serves as an indicator of the present H2O2 concentration. In the present work, a theoretical approach considering the sensor’s thermochemistry and physical transport phenomena was formulated to evaluate the temperature rise based on the energy content of gaseous H2O2. In a further part of this work, three polymers have been analyzed with respect to their application as passivation materials. The examined polymers are photoresist SU-8, perfluoroalkoxy (PFA) and fluorinated ethylene propylene (FEP). Thermal analyses by means of differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) have been conducted to determine the operation limits of the polymers. The overall chemical resistance and stability of the polymers against the harsh environmental conditions during the sterilization process have been examined by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR).
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.electacta.2015.06.126
SN  - 0013-4686
VL  - 183
SP  - 130
EP  - 136
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Strategies for biosensoric detection of potential drugs in nature
JF  - Biomedizinische Technik. 49 (2004), H. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1004
EP  - 1005
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Sterilization of Objects, Products, and Packaging Surfaces and Their Characterization in Different Fields of Industry: The Status in 2020
JF  - physica status solidi (a) applications and materials science
N2  - The treatment method to deactivate viable microorganisms from objects or products is termed sterilization. There are multiple forms of sterilization, each intended to be applied for a specific target, which depends on—but not limited to—the thermal, physical, and chemical stability of that target. Herein, an overview on the currently used sterilization processes in the global market is provided. Different sterilization techniques are grouped under a category that describes the method of treatment: radiation (gamma, electron beam, X-ray, and ultraviolet), thermal (dry and moist heat), and chemical (ethylene oxide, ozone, chlorine dioxide, and hydrogen peroxide). For each sterilization process, the typical process parameters as defined by regulations and the mode of antimicrobial activity are summarized. Finally, the recommended microorganisms that are used as biological indicators to validate sterilization processes in accordance with the rules that are established by various regulatory agencies are summarized.
KW  - bioburdens
KW  - sterility tests
KW  - sterilization efficacy
KW  - sterilization methods
KW  - validation methods
Y1  - 2021
U6  - http://dx.doi.org/10.1002/pssa.202000732
SN  - 1862-6319
N1  - Corresponding author: Michael J. Schöning
VL  - 218
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Oberländer, Jan
A1  - Mayer, Marlena
A1  - Greeff, Anton
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Spore-based biosensor to monitor the microbicidal efficacy of gaseous hydrogen peroxide sterilization processes
JF  - Biosensors and Bioelectronics
N2  - In this work, a spore-based biosensor is evaluated to monitor the microbicidal efficacy of sterilization processes applying gaseous hydrogen peroxide (H2O2). The sensor is based on interdigitated electrode structures (IDEs) that have been fabricated by means of thin-film technologies. Impedimetric measurements are applied to study the effect of sterilization process on spores of Bacillus atrophaeus. This resilient microorganism is commonly used in industry to proof the sterilization efficiency. The sensor measurements are accompanied by conventional microbiological challenge tests, as well as morphological characterizations with scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The sensor measurements are correlated with the microbiological test routines. In both methods, namely the sensor-based and microbiological one, a tailing effect has been observed. The results are evaluated and discussed in a three-dimensional calibration plot demonstrating the sensor's suitability to enable a rapid process decision in terms of a successfully performed sterilization.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.bios.2017.12.045
SN  - 0956-5663
VL  - 104
SP  - 87
EP  - 94
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - GEN
A1  - Abdelghani, Adnane
A1  - Menaa, Bouzid
A1  - Obare, Sherine O.
A1  - Schöning, Michael Josef
T1  - Special issue on nanoscale science and technology / guest eds.: Adnane Abdelghani, Bouzid Menaa, Sherine O. Obare, Michael J. Schöning
T2  - International journal of nanotechnology
Y1  - 2013
SN  - 1741-8151 (E-Journal), 1475-7435 (Print)
VL  - Vol. 10
IS  - No. 5-7
SP  - 373
EP  - 619
ER  - 
TY  - JOUR
A1  - Vlasov, Y. G.
A1  - Mourzina, Y. G.
A1  - Legin, A. V.
A1  - Ermelenko, Y. E.
A1  - Schubert, J.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
T1  - Solid-state thin film sensors based on chalcogenide materials prepared by planar technology and pulsed laser deposition
JF  - Russian Journal of Applied Chemistry. 75 (2002), H. 3
Y1  - 2002
SN  - 1070-4272
SP  - 351
EP  - 356
ER  - 
TY  - JOUR
A1  - Furuichi, K.
A1  - Yoshinobu, T.
A1  - Ermelenko, T.
A1  - Mourzina, Y.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - Simultaneous visualization of multiple ions by the chemical imaging sensor
JF  - Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan
Y1  - 2001
N1  - Chemical sensors; 17.2001 Suppl. B; East Asian Conference on Chemical Sensors ; (5, 2001; Nagasaki)
SP  - 399
EP  - 401
PB  - Japan Association of Chemical Sensors
CY  - Kasuga, Fukuoka-ken
ER  - 
TY  - JOUR
A1  - Turek, Monik
A1  - Heiden, Wolfgang
A1  - Guo, Sharon
A1  - Riesen, Alfred
A1  - Schubert, Jürgen
A1  - Zander, Willi
A1  - Krüger, Peter
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Simultaneous detection of cyanide and heavy metals for environmental analysis by means of µISEs
JF  - Physica Status Solidi (A). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 817
EP  - 823
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Pieper, Martin
T1  - Simulating the electromagnetic‐thermal treatment of thin aluminium layers for adhesion improvement
JF  - Physica status solidi (a)
N2  - A composite layer material used in packaging industry is made from joining layers of different materials using an adhesive. An important processing step in the production of aluminium-containing composites is the surface treatment and consequent coating of adhesive material on the aluminium surface. To increase adhesion strength between aluminium layer and the adhesive material, the foil is heat treated. For efficient heating, induction heating was considered as state-of-the-art treatment process. Due to the complexity of the heating process and the unpredictable nature of the heating source, the control of the process is not yet optimised. In this work, a finite element analysis of the process was established and various process parameters were studied. The process was simplified and modelled in 3D. The numerical model contains an air domain, an aluminium layer and a copper coil fitted with a magnetic field concentrating material. The effect of changing the speed of the aluminium foil (or rolling speed) was studied with the change of the coil current. Statistical analysis was used for generating a general control equation of coil current with changing rolling speed.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431893
SN  - 1862-6319
VL  - Vol. 212
IS  - 6
SP  - 1234
EP  - 1241
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
T1  - Silicon-based field-effect structures – From dielectrics to bioelectronics
JF  - Dielectrics in emerging technologies : proceedings of the international symposium ; [papers presented at the First International Symposium on Science and Technology of Dielectrics in Emerging Fields held from 27th April to 2nd May 2003 in Paris, France] / sponsoring divisions: Dielectric Science and Technology, Electronics. Ed.: D. Misra.
Y1  - 2003
SN  - 1-56677-346-6
N1  - International Symposium on Science and Technology of Dielectrics in Emerging Fields ; (1, 2003, Paris)
SP  - 31
EP  - 37
PB  - Electrochemical Society
CY  - Pennington, NJ
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Silicon-based field-effect devices with nanostructured surfaces for bio-/chemical sensing
JF  - Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009
Y1  - 2009
SP  - 51
EP  - 53
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Silicon-based field-effect devices for (bio-)chemical sensing
JF  - International Conference on Advanced Semiconductor Devices and Microsystems, 2008. ASDAM 2008
Y1  - 2008
SN  - 978-1-4244-2325-5
SP  - 31
EP  - 38
CY  - Smolenice, Slovakia
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Silicon-based chemical and biological field-effect sensors
T2  - Encyclopedia of Sensors. Vol. 9 S - Sk
Y1  - 2006
SN  - 1-58883-065-9
SP  - 463
EP  - 534
PB  - ASP, American Scientific Publ.
CY  - Stevenson Ranch, Calif.
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
T1  - Silicon-based biochemical sensors
JF  - CNI - The Center of Nanoelectronic Systems for Information Technology
Y1  - 2003
SP  - 165
EP  - 170
PB  - Foschungszentrum Jülich
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
T1  - Silicon recognizes biochemical parameters: Microchips for analytical sensor applications
JF  - American Laboratory. 32 (2000), H. 16
Y1  - 2000
SN  - 0044-7749
SP  - 24
EP  - 31
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Kloock, Joachim P.
A1  - Knobbe, D.-T.
A1  - Räde, J.
A1  - Keusgen, M.
T1  - Silicon field-effect biosensor for cyanide detection
JF  - Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors
Y1  - 2004
N1  - Chemical sensors ; 20.2004 Suppl. B. IMCS ; (10, 2004, Tsukuba) ; International Meeting on Chemical Sensors ; (10 : ; 2004.07.11-14 : ; Tsukuba)
SP  - 98
EP  - 99
PB  - Japan Association of Chemical Sensors
CY  - Fukuoka
ER  - 
TY  - CHAP
A1  - Bäcker, Matthias
A1  - Schusser, Sebastian
A1  - Leinhos, Marcel
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Sensor system for the monitoring of degradation processes of biodegradable biopolymers
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 4
PB  - VDE-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Krischer, M.
A1  - Molin, D. G. M.
A1  - Akker, N. M. S. van den
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation
JF  - Procedia Engineering
N2  - A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.815
SN  - 1877-7058
N1  - Eurosensors 2015
VL  - 120
SP  - 948
EP  - 951
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Cornelis, Peter
A1  - Givanoudi, Stella
A1  - Yongabi, Derick
A1  - Iken, Heiko
A1  - Duwé, Sam
A1  - Deschaume, Olivier
A1  - Robbens, Johan
A1  - Dedecker, Peter
A1  - Bartic, Carmen
A1  - Wübbenhorst, Michael
A1  - Schöning, Michael Josef
A1  - Heyndrickx, Marc
A1  - Wagner, Patrick
T1  - Sensitive and specific detection of E. coli using biomimetic receptors in combination with a modified heat-transfer method
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.04.026
SN  - 0956-5663
VL  - 136
SP  - 97
EP  - 105
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wu, Chunsheng
A1  - Poghossian, Arshak
A1  - Bronder, Thomas
A1  - Schöning, Michael Josef
T1  - Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor
JF  - Sensors and Actuators B: Chemical
N2  - A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules.
KW  - Layer-by-layer adsorption
KW  - Poly(allylamine hydrochloride)
KW  - Label-free detection
KW  - DNA biosensor
KW  - LAPS
KW  - Field effect
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.snb.2016.02.004
SN  - 0925-4005
IS  - 229
SP  - 506
EP  - 512
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Christiaens, P.
A1  - Williams, O. A.
A1  - Haenen, K.
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Sensing charged macromolecules with nanocrystalline diamond-based field-effect capacitive sensors
JF  - Journal of Contemporary Physics. 43 (2008), H. 2
Y1  - 2008
SN  - 1934-9378
N1  - Armenian Academy of Sciences
SP  - 77
EP  - 81
ER  - 
TY  - CHAP
A1  - Werner, Frederik
A1  - Yoshinobu, T.
A1  - Miyamoto, K.
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Semiconductor-based sensors for imaging of chemical processes
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 5
PB  - VDE-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Lüth, Hans
T1  - Semiconductor-based field-effect structures for chemical sensing
Y1  - 2001
SP  - 188
EP  - 198
ER  - 
TY  - JOUR
A1  - Spelthahn, Heiko
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Self-aligned nanogaps and nanochannels via conventional photolithography and pattern-size reduction technique
JF  - Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI
Y1  - 2009
SN  - 0013-4686
SP  - 6010
EP  - 6014
ER  - 
TY  - JOUR
A1  - Givanoudi, Stella
A1  - Cornelis, Peter
A1  - Rasschaert, Geertrui
A1  - Wackers, Gideon
A1  - Iken, Heiko
A1  - Rolka, David
A1  - Yongabi, Derick
A1  - Robbens, Johan
A1  - Schöning, Michael Josef
A1  - Heyndrickx, Marc
A1  - Wagner, Patrick
T1  - Selective Campylobacter detection and quantification in poultry: A sensor tool for detecting the cause of a common zoonosis at its source
JF  - Sensors and Actuators B: Chemical
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.snb.2021.129484
SN  - 0925-4005
IS  - In Press, Journal Pre-proof
SP  - Article 129484
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Screen-printed carbon electrodes modified with graphene oxide for the design of a reagent-free NAD+-dependent biosensor array
JF  - Analytical Chemistry
Y1  - 2019
U6  - http://dx.doi.org/10.1021/acs.analchem.9b04481
VL  - 91
IS  - 23
SP  - 15293
EP  - 15299
PB  - ACS Publications
CY  - Washington
ER  - 
TY  - CHAP
A1  - Miyamoto, Ko-ichiro
A1  - Suto, Takeyuki
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Restraining the Diffusion of Photocarriers to Improve the Spatial Resolution of the Chemical Imaging Sensor
T2  - MDPI Proceedings
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1040477
N1  - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017
VL  - 1
IS  - 4
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Recent progress in silicon-based biologically sensitive field-effect devices
JF  - Current Opinion in Electrochemistry
N2  - Biologically sensitive field-effect devices (BioFEDs) advantageously combine the electronic field-effect functionality with the (bio)chemical receptor’s recognition ability for (bio)chemical sensing. In this review, basic and widely applied device concepts of silicon-based BioFEDs (ion-sensitive field-effect transistor, silicon nanowire transistor, electrolyte-insulator-semiconductor capacitor, light-addressable potentiometric sensor) are presented and recent progress (from 2019 to early 2021) is discussed. One of the main advantages of BioFEDs is the label-free sensing principle enabling to detect a large variety of biomolecules and bioparticles by their intrinsic charge. The review encompasses applications of BioFEDs for the label-free electrical detection of clinically relevant protein biomarkers, deoxyribonucleic acid molecules and viruses, enzyme-substrate reactions as well as recording of the cell acidification rate (as an indicator of cellular metabolism) and the extracellular potential.
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.coelec.2021.100811
SN  - 2451-9103
IS  - Article number: 100811
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Yoshinobu, Tatsuo
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Recent developments of chemical imaging sensor systems based on the principle of the light-addressable potentiometric sensor
JF  - Sensors and actuators B: Chemical
N2  - The light-addressable potentiometric sensor (LAPS) is an electrochemical sensor with a field-effect structure to detect the variation of the Nernst potential at its sensor surface, the measured area on which is defined by illumination. Thanks to this light-addressability, the LAPS can be applied to chemical imaging sensor systems, which can visualize the two-dimensional distribution of a particular target ion on the sensor surface. Chemical imaging sensor systems are expected to be useful for analysis of reaction and diffusion in various electrochemical and biological samples. Recent developments of LAPS-based chemical imaging sensor systems, in terms of the spatial resolution, measurement speed, image quality, miniaturization and integration with microfluidic devices, are summarized and discussed.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.snb.2014.09.002
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
VL  - 207, Part B
SP  - 926
EP  - 932
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Recent advances in biologically sensitive field-effect transistors (BioFETs)
JF  - Analyst. 127 (2002)
Y1  - 2002
SN  - 0003-2654
SP  - 1137
EP  - 1151
ER  - 
TY  - JOUR
A1  - Kirchner, Patrick
A1  - Oberländer, Jan
A1  - Friedrich, Peter
A1  - Rysstad, G.
A1  - Berger, J.
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Realization of a calorimetric gas sensor on polyimide foil for applications in aseptic food industry
JF  - Procedia Engineering. 5 (2010)
Y1  - 2010
SN  - 1877-7058
N1  - Eurosensor XXIV Conference
SP  - 264
EP  - 267
ER  - 
TY  - JOUR
A1  - Kirchner, Patrick
A1  - Oberländer, Jan
A1  - Friedrich, Peter
A1  - Berger, Jörg
A1  - Rysstad, Gunnar
A1  - Schöning, Michael Josef
A1  - Keusgen, Michael
T1  - Realisation of a calorimetric gas sensor on polyimide foil for applications in aseptic food industry
JF  - Sensors and Actuators B: Chemical
N2  - A calorimetric gas sensor is presented for the monitoring of vapour-phase H2O2 at elevated temperature during sterilisation processes in aseptic food industry. The sensor was built up on a flexible polyimide foil (thickness: 25 μm) that has been chosen due to its thermal stability and low thermal conductivity. The sensor set-up consists of two temperature-sensitive platinum thin-film resistances passivated by a layer of SU-8 photo resist and catalytically activated by manganese(IV) oxide. Instead of an active heating structure, the calorimetric sensor utilises the elevated temperature of the evaporated H2O2 aerosol. In an experimental test rig, the sensor has shown a sensitivity of 4.78 °C/(%, v/v) in a H2O2 concentration range of 0%, v/v to 8%, v/v. Furthermore, the sensor possesses the same, unchanged sensor signal even at varied medium temperatures between 210 °C and 270 °C of the gas stream. At flow rates of the gas stream from 8 m3/h to 12 m3/h, the sensor has shown only a slightly reduced sensitivity at a low flow rate of 8 m3/h. The sensor characterisation demonstrates the suitability of the calorimetric gas sensor for monitoring the efficiency of industrial sterilisation processes.
KW  - Sterilisation process
KW  - Hydrogen peroxide
KW  - Polyimide
KW  - Calorimetric gas sensor
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.snb.2011.01.032
SN  - 0925-4005
N1  - Part of special issue "Eurosensors XXIV, 2010"
VL  - 170
SP  - 60
EP  - 66
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bertz, Morten
A1  - Molinnus, Denise
A1  - Schöning, Michael Josef
A1  - Homma, Takayuki
T1  - Real-time monitoring of H₂O₂ sterilization on individual bacillus atrophaeus spores by optical sensing with trapping Raman spectroscopy
JF  - Chemosensors
N2  - Hydrogen peroxide (H₂O₂), a strong oxidizer, is a commonly used sterilization agent employed during aseptic food processing and medical applications. To assess the sterilization efficiency with H₂O₂, bacterial spores are common microbial systems due to their remarkable robustness against a wide variety of decontamination strategies. Despite their widespread use, there is, however, only little information about the detailed time-resolved mechanism underlying the oxidative spore death by H₂O₂. In this work, we investigate chemical and morphological changes of individual Bacillus atrophaeus spores undergoing oxidative damage using optical sensing with trapping Raman microscopy in real-time. The time-resolved experiments reveal that spore death involves two distinct phases: (i) an initial phase dominated by the fast release of dipicolinic acid (DPA), a major spore biomarker, which indicates the rupture of the spore’s core; and (ii) the oxidation of the remaining spore material resulting in the subsequent fragmentation of the spores’ coat. Simultaneous observation of the spore morphology by optical microscopy corroborates these mechanisms. The dependence of the onset of DPA release and the time constant of spore fragmentation on H₂O₂ shows that the formation of reactive oxygen species from H₂O₂ is the rate-limiting factor of oxidative spore death.
KW  - DPA (dipicolinic acid)
KW  - sterilization
KW  - Bacillus atrophaeus spores
KW  - optical trapping
KW  - Raman spectroscopy
KW  - optical sensor setup
Y1  - 2023
U6  - http://dx.doi.org/10.3390/chemosensors11080445
SN  - 2227-9040
N1  - This article belongs to the Special Issue "Biosensors and Chemical Sensors for Food and Healthcare Monitoring—Celebrating the 10th Anniversary"
VL  - 8
IS  - 11
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Schusser, Sebastian
A1  - Bäcker, M.
A1  - Leinhos, Marcel
A1  - Schöning, Michael Josef
T1  - Real-time in-situ electrical monitoring of the degradation of biopolymers using semiconductor field-effect devices
T2  - Biodegradable biopolymers. Vol. 1
Y1  - 2015
SN  - 978-1-63483-632-6
SP  - 135
EP  - 153
PB  - Nova Science Publ.
CY  - Hauppauge
ER  - 
TY  - JOUR
A1  - Bohrn, U.
A1  - Stütz, E.
A1  - Fleischer, M.
A1  - Schöning, Michael Josef
T1  - Real-time detection of CO by eukaryotic cells
JF  - Procedia Engineering. 5 (2010)
Y1  - 2010
SN  - 1877-7058
N1  - Eurosensor XXIV Conference
SP  - 17
EP  - 20
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Geissler, Hanno
A1  - Schöning, Michael Josef
T1  - Rapid methods and sensors for milk quality monitoring and spoilage detection
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.04.040
SN  - 0956-5663
VL  - 140
IS  - Article 111272
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Grinsven, B. van
A1  - Bon, N. vanden
A1  - Grieten, L.
A1  - Murib, M.
A1  - Janssen, S. D.
A1  - Haenen, K.
A1  - Schneider, E.
A1  - Ingebrandt, E.
A1  - Schöning, Michael Josef
A1  - Vermeeren, V.
A1  - Ameloot, M.
A1  - Michiels, L.
A1  - Thoelen, R.
A1  - Ceuninck, W. de
A1  - Wagner, P.
T1  - Rapid assessment of the stability of DNA duplexes by impedimetric real-time monitoring of chemically induced denaturation
JF  - Lab on a Chip
Y1  - 2011
SN  - 1473-0197
VL  - 11
IS  - 9
SP  - 1656
EP  - 1663
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Selmer, Thorsten
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.111332
VL  - 139
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kloock, Joachim P.
A1  - Mourzina, Y.
A1  - Schubert, J.
A1  - Ermelenko, Y.
A1  - Schöning, Michael Josef
T1  - Pulsed laser deposition: A tool for fabricating thin-film microsensors
JF  - Biomedizinische Technik. 49 (2004), H. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1032
EP  - 1033
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Mourzina, Yu.G.
A1  - Schubert, J.
A1  - Zander, W.
A1  - Legin, A.
A1  - Vlasov, Y. G.
A1  - Lüth, H.
T1  - Pulsed laser deposition – an innovative technique for preparing inorganic thin films
JF  - Electroanalysis. 13 (2001), H. 8-9
Y1  - 2001
SN  - 1040-0397
SP  - 727
EP  - 732
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schaub, A.
A1  - Zundel, A.
A1  - Beckers, L.
A1  - Schubert, J.
A1  - Zander, W.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Pulsed laser deposition as a novel thin film preparation method for silicon-based field effect sensors
JF  - Proceedings of the 25th European Solid State Device Research Conference : the Netherlands Congress Centre, The Hague, the Netherlands, 25th - 27th September 1995 / ESSDERC '95. Ed. by H. C. de Graaff
Y1  - 1995
SN  - 2-86332-182-X
N1  - ESSDERC ; (25, 1995, 's-Gravenhage) ; European Solid State Device Research Conference (ESSDERC) ; (25 : ; 1995.09.25-27 : ; Den Haag)
SP  - 601
EP  - 604
PB  - Ed. Frontières
CY  - Gif-sur-Yvette
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schubert, Jürgen
A1  - Zander, Willy
A1  - Müller-Veggian, Mattea
T1  - Pulsed laser deposition as a novel preparation technique for chemical microsensors
JF  - Proceedings of SPIE 3857, Chemical Microsenors and Applications II, 124 (November 18, 1999). 3857 (1999)
Y1  - 1999
SP  - 124
EP  - 134
ER  - 
TY  - CHAP
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Preface of the Special Issue of I3S 2005 in Jülich (Germany)
N2  - International Symposium on Sensor Science, I3S 2005 <3; 2005; Juelich, Germany> In: Sensors 2006, 6, 260-261 ISSN 1424-8220
KW  - Biosensor
KW  - I3S 2005
KW  - International Symposium on Sensor Science
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1365
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Doll, Theodor
A1  - Wagner, Patrick
T1  - Preface / Doll, Theodor ; Wagner, Patrick ; Schöning, Michael J.
JF  - physica status solidi (a) . 206 (2009), H. 3
Y1  - 2009
SN  - 1862-6319
N1  - Special Issue: Engineering of Functional Interfaces (EnFI 08)
SP  - 389
EP  - 390
ER  - 
TY  - JOUR
A1  - Yoshinobu, T.
A1  - Ui, Y.
A1  - Iwasaki, H.
A1  - Näther, Niko
A1  - Koudelka-Hep, M.
A1  - Schöning, Michael Josef
T1  - Potentiometric imaging in a microfluidic channel
JF  - Biomedizinische Technik. 49 (2004), H. 2
Y1  - 2004
SN  - 0932-4666
SP  - 998
EP  - 999
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Cherstvy, A.
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Possibilities and limitations of label-free detection of DNA hybridization with field-effect-based devices
JF  - Sensors and Actuators B. 111-112 (2005)
Y1  - 2005
SN  - 0925-4005
N1  - Eurosensors XVIII 2004 — The 18th European Conference on Solid-State Transducers
SP  - 470
EP  - 480
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Cherstvy, A.
A1  - Schöning, Michael Josef
T1  - Possibilities and limitations of label-free detection of DNA hybridization with field-effect based devices
JF  - Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].
Y1  - 2004
SN  - 88-7621-282-5
N1  - Eurosensors ; (18, 2004, Roma)
SP  - 173
EP  - 176
CY  - Roma
ER  - 
TY  - JOUR
A1  - Yoshinobu, T.
A1  - Schöning, Michael Josef
A1  - Otto, R.
A1  - Furuichi, K.
A1  - Mourzina, Y.
A1  - Ermelenko, Y.
A1  - Iwasaki, H.
T1  - Portable light-addressable potentiometric sensor (LAPS) for multisensor applications
JF  - Sensors and Actuators B. 95 (2003), H. 1-3
Y1  - 2003
SN  - 0925-4005
SP  - 352
EP  - 356
ER  - 
TY  - JOUR
A1  - Yoshinobu, T.
A1  - Schöning, Michael Josef
A1  - Otto, R.
A1  - Furuichi, K.
A1  - Mourzina, Yu
A1  - Ermelenko, Yu
A1  - Iwasaki, I.
T1  - Portable light-addressable potentiometric sensor (LAPS) for multisensor applications
JF  - Book of abstracts / ed. by J. Saneistr.
Y1  - 2002
SN  - 80-01-02576-4
N1  - Eurosensors ; (16, 2002, Praha)
SP  - 898
EP  - 901
PB  - Czech Technical University, Faculty of Electrical Engineering, Department of Measurement
CY  - Prague
ER  - 
TY  - JOUR
A1  - Thust, Marion
A1  - Schöning, Michael Josef
A1  - Frohnhoff, S.
A1  - Arens-Fischer, R.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Porous silicon as a substrate material for potentiometric biosensors
JF  - Measurement Science and Technology
Y1  - 1996
U6  - http://dx.doi.org/10.1088/0957-0233/7/1/003
VL  - 7
IS  - 1
SP  - 26
EP  - 29
ER  - 
TY  - JOUR
A1  - Kloock, Joachim P.
A1  - Moreno, Lia
A1  - Bratov, A.
A1  - Huachupoma, S.
A1  - Xu, J.
A1  - Wagner, Torsten
A1  - Yoshinobu, T.
A1  - Ermolenko, Y.
A1  - Vlasov, Y. G.
A1  - Schöning, Michael Josef
T1  - PLD-prepared cadmium sensors based on chalcogenide glasses —ISFET, LAPS and &#956;ISE semiconductor structures
JF  - Sensors and Actuators B: Chemical. 118 (2006), H. 1-2
Y1  - 2006
SN  - 0925-4005
N1  - Eurosensors XIX - Eurosensors XIX - The 19th European Conference on Solid-State Transducers
SP  - 149
EP  - 155
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Kramer, F.
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bratov, A.
A1  - Abramova, N.
A1  - Schöning, Michael Josef
T1  - Planar and 3D interdigitated electrodes for biosensing applications: The impact of a dielectric barrier on the sensor properties
JF  - Physica Status Solidi (A) - Applications and Materials Science
N2  - Planar and three-dimensional (3D) interdigitated electrodes (IDE) with electrode digits separated by an insulating barrier of different heights were electrochemically characterized and compared in terms of their sensing properties. Due to the impact of the surface resistance, both types of IDE structures display a non-linear behavior in low-ionic strength solutions. The experimental data were fitted to an electrical equivalent circuit and interpreted taking into account the surface-charge-governed properties. The effect of a charged polyelectrolyte layer electrostatically assembled onto the sensor surface on the surface resistance in solutions with different KCl concentration is studied. In case of the same electrode footprint, 3D-IDEs show a larger cell constant and a higher sensitivity to molecular adsorption than that of planar IDEs. The obtained results demonstrate the potential of 3D-IDEs as a new transducer structure for a direct label-free sensing of charged molecules.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/pssa.201330416
SN  - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1357
EP  - 1363
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Martens, D.
A1  - Liu, X.
A1  - Bienstman, P.
A1  - Fahlman, M.
A1  - Schöning, Michael Josef
A1  - Michiels, L.
A1  - Haenen, K.
A1  - Serpengüzel, A.
A1  - Wagner, Patrick
T1  - Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands
JF  - Sensors and actuators A: Physical
N2  - In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.sna.2014.11.024
SN  - 1873-3069 (E-Journal); 0924-4247 (Print)
VL  - 222
SP  - 212
EP  - 219
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Murib, Mohammed Sharif
A1  - Yeap, Weng-Siang
A1  - Martens, Daan
A1  - Bienstman, Peter
A1  - Ceuninck, Ward de
A1  - Grinsven, Bart van
A1  - Schöning, Michael Josef
A1  - Michiels, Luc
A1  - Haenen, Ken
A1  - Ameloot, Marcel
A1  - Serpengüzel, Ali
A1  - Wagner, Patrick
T1  - Photonic detection and characterization of DNA using sapphire microspheres
JF  - Journal of biomedical optics
N2  - A microcavity-based deoxyribonucleic acid (DNA) optical biosensor is demonstrated for the first time using synthetic sapphire for the optical cavity. Transmitted and elastic scattering intensity at 1510 nm are analyzed from a sapphire microsphere (radius 500  μm, refractive index 1.77) on an optical fiber half coupler. The 0.43 nm angular mode spacing of the resonances correlates well with the optical size of the sapphire sphere. Probe DNA consisting of a 36-mer fragment was covalently immobilized on a sapphire microsphere and hybridized with a 29-mer target DNA. Whispering gallery modes (WGMs) were monitored before the sapphire was functionalized with DNA and after it was functionalized with single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The shift in WGMs from the surface modification with DNA was measured and correlated well with the estimated thickness of the add-on DNA layer. It is shown that ssDNA is more uniformly oriented on the sapphire surface than dsDNA. In addition, it is shown that functionalization of the sapphire spherical surface with DNA does not affect the quality factor (Q≈104) of the sapphire microspheres. The use of sapphire is especially interesting because this material is chemically resilient, biocompatible, and widely used for medical implants.
Y1  - 2014
U6  - http://dx.doi.org/10.1117/1.JBO.19.9.097006
SN  - 1560-2281 (E-Journal); 1083-3668 (Print)
VL  - 19
IS  - 9
SP  - 097006
PB  - SPIE
CY  - Bellingham
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Nagamine Komesu, Cindy A.
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Photoelectrochemical enzymatic penicillin biosensor: A proof-of-concept experiment
JF  - Electrochemical Science Advances
N2  - Photoelectrochemical (PEC) biosensors are a rather novel type of biosensors thatutilizelighttoprovideinformationaboutthecompositionofananalyte,enablinglight-controlled multi-analyte measurements. For enzymatic PEC biosensors,amperometric detection principles are already known in the literature. In con-trast, there is only a little information on H+-ion sensitive PEC biosensors. Inthis work, we demonstrate the detection of H+ions emerged by H+-generatingenzymes, exemplarily demonstrated with penicillinase as a model enzyme on atitanium dioxide photoanode. First, we describe the pH sensitivity of the sensorand study possible photoelectrocatalytic reactions with penicillin. Second, weshow the enzymatic PEC detection of penicillin.
KW  - enzymatic biosensor
KW  - penicillin
KW  - penicillinase
KW  - photoelectrochemistry
KW  - titanium dioxide photoanode
Y1  - 2021
U6  - http://dx.doi.org/10.1002/elsa.202100131
SN  - 2698-5977
N1  - Corresponding auhtor: Michael J. Schöning
VL  - 2
IS  - 4
SP  - 1
EP  - 5
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T
A1  - Mourzina, Y.
A1  - Levichev, S.
A1  - Furuichi, K.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Photocurable membranes for ion-selective light-addressable potentiometric sensors
JF  - Sensors and Actuators B. 85 (2002), H. 1-2
Y1  - 2002
SN  - 0925-4005
SP  - 79
EP  - 85
ER  - 
TY  - JOUR
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Kanoh, Shin`ichiro
A1  - Schöning, Michael Josef
T1  - Phase-mode operation of FDM-LAPS
JF  - Sensor letters
Y1  - 2011
SN  - 1546-1971
VL  - 9
IS  - 2
SP  - 691
EP  - 694
PB  - American Scientific Publishers
CY  - Stevenson Ranch, Calif.
ER  - 
TY  - JOUR
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Kanoh, Shin`ichiro
A1  - Schöning, Michael Josef
T1  - Phase-mode LAPS and its application to chemical imaging
JF  - Sensors and Actuators B: Chemical. 154 (2011), H. 1
Y1  - 2011
SN  - 1873-3077
SP  - 28
EP  - 32
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Buniatyan, Vahe V.
A1  - Abouzar, Maryam H.
A1  - Martirosyan, Norayr W.
A1  - Schubert, Jürgen
A1  - Gevorgian, Spartak
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - pH-sensitive properties of barium strontium titanate (BST) thin films prepared by pulsed laser deposition technique
JF  - Physica Status Solidi (A). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 824
EP  - 830
ER  - 
TY  - JOUR
A1  - Christiaens, P.
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Wagner, Torsten
A1  - Bijnens, N.
A1  - Williams, O. A.
A1  - Daenen, M.
A1  - Haenen, K.
A1  - Douthéret, O.
A1  - Haen, J. d´
A1  - Mekhalif, Z.
A1  - Schöning, Michael Josef
A1  - Wagner, P.
T1  - pH sensitivity of nanocrystalline diamond films
JF  - Physica status solidi (A). 204 (2007), H. 9
Y1  - 2007
SN  - 0031-8965
SP  - 2925
EP  - 2930
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
T1  - pH and ion sensitivity of a field-effect EIS (electrolyte-insulator-semiconductor) sensor covered with polyelectrolyte multilayers
JF  - Journal of Solid State Electrochemistry. 13 (2009), H. 1
Y1  - 2009
SN  - 1433-0768
N1  - This manuscript is an invited paper to the special issue on “Solid-state potentiometric sensors” (Guest editor: Johan Bobacka).
SP  - 115
EP  - 122
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Razavi, Arash
A1  - Besmehn, Astrid
A1  - Bijnens, Nathalie
A1  - Williams, Oliver A.
A1  - Haenen, Ken
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Penicillin detection with nanocrystalline-diamond field-effect sensor
JF  - physica status solidi (a). 205 (2008), H. 9
Y1  - 2008
SN  - 1862-6319
N1  - Special Issue: Hasselt Diamond Workshop 2008 - SBDD XIII
SP  - 2141
EP  - 2145
ER  - 
TY  - JOUR
A1  - Koch, Claudia
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Wege, Christian
T1  - Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors
JF  - Nanotheranostics
N2  - The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts.
Y1  - 2018
U6  - http://dx.doi.org/10.7150/ntno.22114
SN  - 2206-7418
VL  - 2
IS  - 2
SP  - 184
EP  - 196
PB  - Ivyspring
CY  - Sydney
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Thust, M.
A1  - Schroth, P.
A1  - Steffen, A.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of silicon-based field-effect structures
JF  - Sensors and Materials. 13 (2001), H. 4
Y1  - 2001
SN  - 0392-2510
SP  - 207
EP  - 223
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Simonis, A.
A1  - Ecken, H.
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?
JF  - Sensors and Actuators B. 78 (2001), H. 1-3
Y1  - 2001
SN  - 0925-4005
SP  - 237
EP  - 242
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, T.
A1  - Simonis, A.
A1  - Ecken, H.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?
JF  - Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]
Y1  - 2000
SN  - 87-89935-50-0
N1  - Eurosensors ; (14, 2000, København) ; Eurosensors ; (14 : ; 2000.08.27-30 : ; Copenhagen) ; European Conference on Solid-State Transducers ; (14 : ; 2000.08.27-30 : ; Copenhagen)
SP  - 27
EP  - 30
PB  - MIC, Mikroelektronik Centret
CY  - Lyngby, Denmark
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Penicillin biosensor based on a capacitive field-effect structure functionalized with a dendrimer/carbon nanotube multilayer
JF  - Biosensors and Bioelectronics. 25 (2009), H. 2
Y1  - 2009
SN  - 0956-5663
SP  - 497
EP  - 501
ER  - 
TY  - JOUR
A1  - Faßbender, F.
A1  - Schmitt, G.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
A1  - Buß, G.
A1  - Schultze, J. W.
T1  - Passivation and corrosion of microsensor devices exemplified at microelectrode arrays
JF  - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.
Y1  - 1999
SN  - 90-76699-02-X
N1  - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague)
SP  - 953
EP  - 956
CY  - The Hague, The Netherlands
ER  - 
TY  - JOUR
A1  - Schmitt, G.
A1  - Schultze, J.-W.
A1  - Faßbender, F.
A1  - Buß, G.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Passivation and corrosion of microelectrode arrays
JF  - Electrochimica Acta. 44 (1999), H. 21-22
Y1  - 1999
SN  - 0013-4686
SP  - 3865
EP  - 3883
ER  - 
TY  - JOUR
A1  - Schmitt, G.
A1  - Faßbender, F.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
A1  - Schultze, J. W.
A1  - Buß, G.
T1  - Passivation and corrosion of microelectrode arrays
JF  - Materials and Corrosion. 51 (2000), H. 1
Y1  - 2000
SN  - 0947-5117
SP  - 20
EP  - 25
ER  - 
TY  - JOUR
A1  - Gun, Jenny
A1  - Rizkov, Dan
A1  - Lev, Ovadia
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Oxygen plasma-treated gold nanoparticle-based field-effect devices as transducer structures for bio-chemical sensing
JF  - Microchimica Acta. 164 (2008), H. 3-4
Y1  - 2008
SN  - 1436-5073
SP  - 395
EP  - 404
ER  - 
TY  - JOUR
A1  - Pita, Marcos
A1  - Krämer, Melina
A1  - Zouh, Jian
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Fernandez, Victor M.
A1  - Katz, Evgeny
T1  - Optoelectronic Properties of Nanostructured Ensembles Controlled by Biomolecular Logic Systems
JF  - ACS Nano. 10 (2008), H. 2
Y1  - 2008
SN  - 1936-086X
SP  - 2160
EP  - 2166
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Mätzkow, Malte
A1  - Durán, Marlena Palomar
A1  - Greeff, Anton
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Optimization of the immobilization of bacterial spores on glass substrates with organosilanes
JF  - Physica status solidi (A) : Applications and materials science
N2  - Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication.
KW  - silanization
KW  - organosilanes
KW  - immobilization
KW  - endospores
KW  - biosensors
KW  - Bacillus atrophaeus
Y1  - 2016
U6  - http://dx.doi.org/10.1002/pssa.201532914
SN  - 1862-6319
VL  - 213
IS  - 6
SP  - 1463
EP  - 1470
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Faßbender, F.
A1  - Schmitt, G.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
A1  - Buß, G.
A1  - Schultze, J. W.
T1  - Optimization of passivation layers for corrosion protection of silicon-based microelectrode arrays
JF  - Sensors and Actuators B. 68 (2000), H. 1-3
Y1  - 2000
SN  - 0925-4005
SP  - 128
EP  - 133
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Optimization of Cell-Based Multi-Chamber LAPS Measurements Utilizing FPGA-Controlled Laser-Diode Modules
JF  - physica status solidi a : applications and materials sciences
N2  - A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric device, which detects concentration changes of an analyte solution on the sensor surface in a spatially resolved way. It uses a light source to generate electron–hole pairs inside the semiconductor, which are separated in the depletion region due to an applied bias voltage across the sensor structure and hence, a surface-potential-dependent photocurrent can be read out. However, depending on the beam angle of the light source, scattering effects can occur, which influence the recorded signal in LAPS-based differential measurements. To solve this problem, a novel illumination unit based on a field programmable gate array (FPGA) consisting of 16 small-sized tunable infrared laser-diode modules (LDMs) is developed. Due to the improved focus of the LDMs with a beam angle of only 2 mrad, undesirable scattering effects are minimized. Escherichia coli (E. coli) K12 bacteria are used as a test microorganism to study the extracellular acidification on the sensor surface. Furthermore, a salt bridge chamber is built up and integrated with the LAPS system enabling multi-chamber differential measurements with a single Ag/AgCl reference electrode.
Y1  - 2018
U6  - http://dx.doi.org/10.1002/pssa.201800058
SN  - 1862-6319
VL  - 215
IS  - 15
SP  - Article number 1800058
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Mariano, K.
A1  - Keusgen, M.
A1  - Selmer, Thorsten
A1  - Schöning, Michael Josef
T1  - Optimization of an Enzyme-based Multi-parameter Biosensor for Monitoring Biogas Processes
JF  - Procedia Engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.702
SN  - 1877-7058
N1  - Part of special issue "Eurosensors 2015"
VL  - 120
SP  - 532
EP  - 535
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Yazici, Yasemen
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Optimization of an amperometric biosensor array for simultaneous measurement of ethanol, formate, d- and l-lactate
JF  - Electrochimica Acta
N2  - The immobilization of NAD+-dependent dehydrogenases, in combination with a diaphorase, enables the facile development of multiparametric sensing devices. In this work, an amperometric biosensor array for simultaneous determination of ethanol, formate, d- and l-lactate is presented. Enzyme immobilization on platinum thin-film electrodes was realized by chemical cross-linking with glutaraldehyde. The optimization of the sensor performance was investigated with regard to enzyme loading, glutaraldehyde concentration, pH, cofactor concentration and temperature. Under optimal working conditions (potassium phosphate buffer with pH 7.5, 2.5 mmol L-1 NAD+, 2.0 mmol L-1 ferricyanide, 25 °C and 0.4% glutaraldehyde) the linear working range and sensitivity of the four sensor elements was improved. Simultaneous and cross-talk free measurements of four different metabolic parameters were performed successfully. The reliable analytical performance of the biosensor array was demonstrated by application in a clarified sample of inoculum sludge. Thereby, a promising approach for on-site monitoring of fermentation processes is provided.
KW  - Simultaneous determination
KW  - Enzymatic biosensor
KW  - Diaphorase
KW  - Dehydrogenase
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.electacta.2017.07.119
SN  - 0013-4686
VL  - 251
SP  - 256
EP  - 262
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kirchner, Patrick
A1  - Oberländer, Jan
A1  - Friedrich, Peter
A1  - Berger, Jörg
A1  - Suso, Henri-Pierre
A1  - Kupyna, Andriy
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Optimisation and fabrication of a calorimetric gas sensor built up on a polyimide substrate for H2O2 monitoring
JF  - Physica status solidi (a) : applications and material science. 208 (2011), H. 6
Y1  - 2011
SN  - 1862-6319
SP  - 1235
EP  - 1240
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Jolly, Christina
A1  - Wagner, Patrick
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen
JF  - Procedia Engineering. 25 (2011)
Y1  - 2011
SN  - 1877-7058
N1  - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP  - 1161
EP  - 1164
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Iken, Heiko
A1  - Kirsanov, D.
A1  - Legin, A.
A1  - Schöning, Michael Josef
T1  - Novel Thin-Film Polymeric Materials for the Detection of Heavy Metals
JF  - Procedia Engineering
N2  - A variety of transition metals, e.g., copper, zinc, cadmium, lead, etc. are widely used in industry as components for wires, coatings, alloys, batteries, paints and so on. The inevitable presence of transition metals in industrial processes implies the ambition of developing a proper analytical technique for their adequate monitoring. Most of these elements, especially lead and cadmium, are acutely toxic for biological organisms. Quantitative determination of these metals at low activity levels in different environmental and industrial samples is therefore a vital task. A promising approach to achieve an at-side or on-line monitoring on a miniaturized and cost efficient way is the combination of a common potentiometric sensor array with heavy metal-sensitive thin-film materials, like chalcogenide glasses and polymeric materials, respectively.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.proeng.2012.09.148
SN  - 1877-7058
N1  - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012"
IS  - 47
SP  - 322
EP  - 325
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Guo, Yuanyuan
A1  - Seki, Kosuke
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution
JF  - Applied physics express : APEX
N2  - A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) is proposed to achieve a higher spatial resolution of chemical images. The proposed method employs a combined light source that consists of a modulated light probe, which generates the alternating photocurrent signal, and a ring of constant illumination surrounding it. The constant illumination generates a sheath of carriers with increased concentration which suppresses the spread of photocarriers by enhanced recombination. A device simulation was carried out to verify the effect of constant illumination on the spatial resolution, which demonstrated that a higher spatial resolution can be obtained.
Y1  - 2014
U6  - http://dx.doi.org/10.7567/APEX.7.067301
SN  - 1882-0786 (E-Journa); 1882-0778 (Print)
VL  - 7
IS  - 6
SP  - 067301-4
PB  - IOP
CY  - Bristol
ER  - 
TY  - CHAP
A1  - Arida, Hassan A.
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
T1  - Novel organic membrane-based thin-film microsensors for the determination of heavy metal cations
N2  - A first step towards the fabrication and electrochemical evaluation of thin-film microsensors based on organic PVC membranes for the determination of Hg(II), Cd(II), Pb(II) and Cu(II) ions in solutions has been realised. The membrane-coating mixture used in the preparation of this new type of microsensors is incorporating PVC as supporting matrix, o-nitrophenyloctylether (o-NPOE) as solvent mediator and a recently synthesized Hg[dimethylglyoxime(phene)]2+ and Bis-(4-hydroxyacetophenone)-ethylenediamine as electroactive materials for Hg(II) and Cd(II), respectively. A set of three commercialised ionophores for Cd(II), Pb(II) and Cu(II) has been also used for comparison. Thin-film microsensors based on these membranes showed a Nernstian response of slope (26-30 mV/dec.) for the respective tested cations. The potentiometric response characteristics (linear range, pH range, detection limit and response time) are comparable with those obtained by conventional membranes as well as coated wire electrodes prepared from the same membrane. The realisation of the new organic membrane-based thin-film microsensors overcomes the problem of an insufficient selectivity of solid-state-based thinfilm sensors.
KW  - Biosensor
KW  - Heavy metal detection
KW  - thin-film microsensors
KW  - organic PVC membranes
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1545
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Malkoc, Ü.
A1  - Thust, M.
A1  - Steffen, A.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Novel electrochemical sensors with structured and porous semiconductor/insulator capacitors
JF  - Sensors and Actuators B. 65 (2000), H. 1-3
Y1  - 2000
SN  - 0925-4005
SP  - 288
EP  - 290
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Malkoc, Ü.
A1  - Thust, M.
A1  - Steffen, A.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Novel electrochemical sensors with structured and porous semiconductor/insulator capacitors
JF  - Proceedings of the Seventh International Meeting on Chemical Sensors : 27 - 30 July, 1998, Beijing, P. R. China / ed. Zhi-Gang Zhou
Y1  - 1998
N1  - International Meeting on Chemical Sensors ; (7, 1998, Beijing) ; International Meeting on Chemical Sensors (IMCS) ; (7 : ; 1998.07.27-30 : ; Beijing)
SP  - 885
EP  - 887
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Lüth, H.
T1  - Novel concepts for silicon-based biosensors
JF  - Physica Status Solidi (A) (2001)
Y1  - 2001
SN  - 0031-8965
SP  - 65
EP  - 77
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Berndsen, Lars
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Novel concepts for flow-rate and flow-direction determination by means of pH-sensitive ISFETs
JF  - Proceedings of SPIE. 4560 (2001)
Y1  - 2001
SP  - 19
EP  - 27
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging
JF  - Procedia Engineering. 5 (2010)
Y1  - 2010
SN  - 1877-7058
N1  - Eurosensor XXIV Conference
SP  - 520
EP  - 523
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
T1  - Novel approaches to design siliconbased field-effect sensors
JF  - Electrochemical Microsystem Technologies, New Trends in Electrochemistry Vol. 2
Y1  - 2002
SP  - 384
EP  - 408
PB  - Taylor & Francis
CY  - London New York
ER  - 
TY  - JOUR
A1  - Karschuck, T. L.
A1  - Filipov, Y.
A1  - Bollella, P.
A1  - Schöning, Michael Josef
A1  - Katz, E.
T1  - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction
JF  - International Journal of Unconventional Computing
N2  - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions.
Y1  - 2019
SN  - 1548-7199
VL  - 14
IS  - 3-4
SP  - 235
EP  - 242
PB  - Old City Publishing
CY  - Philadelphia
ER  -