TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schaub, A.
A1  - Zundel, A.
A1  - Beckers, L.
A1  - Schubert, J.
A1  - Zander, W.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Pulsed laser deposition as a novel thin film preparation method for silicon-based field effect sensors
JF  - Proceedings of the 25th European Solid State Device Research Conference : the Netherlands Congress Centre, The Hague, the Netherlands, 25th - 27th September 1995 / ESSDERC '95. Ed. by H. C. de Graaff
Y1  - 1995
SN  - 2-86332-182-X
N1  - ESSDERC ; (25, 1995, 's-Gravenhage) ; European Solid State Device Research Conference (ESSDERC) ; (25 : ; 1995.09.25-27 : ; Den Haag)
SP  - 601
EP  - 604
PB  - Ed. Frontières
CY  - Gif-sur-Yvette
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schubert, Jürgen
A1  - Zander, Willy
A1  - Müller-Veggian, Mattea
T1  - Pulsed laser deposition as a novel preparation technique for chemical microsensors
JF  - Proceedings of SPIE 3857, Chemical Microsenors and Applications II, 124 (November 18, 1999). 3857 (1999)
Y1  - 1999
SP  - 124
EP  - 134
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Baumann, Marcus
A1  - Vilser, Walthard
A1  - Lanzl, Ines M.
T1  - Pulse wave velocity in retinal arteries of healthy volunteers
JF  - British Journal of Ophthalmology (eBJO)
Y1  - 2011
SN  - 1468-2079
VL  - 95
IS  - 11
SP  - 675
EP  - 679
PB  - BMJ Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Streun, M.
A1  - Brandenburg, G.
A1  - Larue, H.
A1  - Saleh, H.
A1  - Zimmermann, E.
A1  - Ziemons, Karl
A1  - Halling, H.
T1  - Pulse shape discrimination of LSO and LuYAP scintillators for depth of interaction detection in PET
JF  - 2002 IEEE Nuclear Science Symposium Conference Record, Vol. 3
N2  - A feasible way to gain the depth of interaction information in a PET scanner is the use of phoswich detectors. In general the layer of interaction is identified front the pulse shape of the corresponding scintillator material. In this work pulses from LSO and LuYAP crystals were investigated in order to find a practical method of distinguishing. It turned out that such a pulse processing could he kept simple due to an additional slow component in the light decay of the LuYAP pulse. At the same time the short decay time guarantees that the major amount of the light output is still collected within a short pulse recording time.
Y1  - 2003
SN  - 1082-3654
SP  - 1636
EP  - 1639
ER  - 
TY  - JOUR
A1  - Streun, M.
A1  - Brandenburg, G.
A1  - Larue, H.
A1  - Saleh, H.
A1  - Zimmermann, E.
A1  - Ziemons, Karl
A1  - Halling, H.
T1  - Pulse shape discrimination of LSO and LuYAP scintillators for depth of interaction detection in PET
JF  - IEEE Transactions on Nuclear Science
N2  - A feasible way to gain the depth of interaction information in a positron emission tomography scanner is the use of phoswich detectors. In general, the layer of interaction is identified from the pulse shape of the corresponding scintillator material. In this work, pulses from LSO and LuYAP crystals were investigated in order to find a practical method of distinguishing. It turned out that such a pulse processing could be kept simple because of an additional slow component in the light decay of the LuYAP pulse. At the same time, the short decay time guarantees that the major amount of the light output is still collected within a short pulse recording time.
Y1  - 2003
SN  - 0018-9499
VL  - 50
IS  - 3
SP  - 344
EP  - 347
ER  - 
TY  - JOUR
A1  - Streun, M.
A1  - Brandenburg, G.
A1  - Larue, H.
A1  - Zimmermann, E.
A1  - Ziemons, Karl
A1  - Halling, H.
T1  - Pulse recording by free-running sampling
JF  - 2000 IEEE Nuclear Science Symposium Conference Record, Vol. 2
N2  - Pulses from a position-sensitive photomultiplier (PS-PMT) are recorded by free running ADCs at a sampling rate of 40 MHz. A four-channel acquisition-board has been developed which is equipped with four 12 bit-ADCs connected to one FPGA (field programmable gate array). The FPGA manages data acquisition and the transfer to the host computer. It can also work as a digital trigger, so a separate hardware-trigger can be omitted. The method of free running sampling provides a maximum of information, besides the pulse charge and amplitude also pulse shape and starting time are contained in the sampled data. These informations are crucial for many tasks such as distinguishing between different scintillator materials, determination of radiation type, pile-up recovery, coincidence detection or time-of-flight applications. The absence of an analog integrator allows coping with very high count rates. Since this method is going to be employed in positron emission tomography (PET), the position of an event is another important information. The simultaneous readout of four channels allows localization by means of center-of-gravity weighting. First results from a test setup with LSO-scintillators coupled to the PS-PMT are presented
Y1  - 2000
SN  - 1082-3654
SP  - 9/179
EP  - 9/181
ER  - 
TY  - JOUR
A1  - Streun, M.
A1  - Brandenburg, G.
A1  - Larue, H.
A1  - Zimmermann, E.
A1  - Ziemons, Karl
A1  - Halling, H.
T1  - Pulse recording by free-running sampling
JF  - IEEE Transactions on Nuclear Science
N2  - Pulses from a position-sensitive photomultiplier (PS-PMT) are recorded by free-running ADCs at a sampling rate of 40 MHz. A four-channel acquisition board has been developed which is equipped with four 12-bit ADCs connected to one field programmable gate array (FPGA). The FPGA manages data acquisition and the transfer to the host computer. It can also work as a digital trigger, so a separate hardware trigger can be omitted. The method of free-running sampling provides a maximum of information, besides the pulse charge and amplitude also pulse shape and starting time are contained in the sampled data. This information is crucial for many tasks such as distinguishing between different scintillator materials, determination of radiation type, pile-up recovery, coincidence detection or time-of-flight applications. The absence of an analog integrator allows very high count rates to be dealt with. Since this method is to be employed in positron emission tomography (PET), the position of an event is also important. The simultaneous readout of four channels allows localization by means of center-of-gravity weighting. First results from a test setup with LSO scintillators coupled to the PS-PMT are presented here
Y1  - 2001
SN  - 0018-9499
VL  - 48
IS  - 3
SP  - 524
EP  - 526
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Müller, Lars-Peter
A1  - Staat, Manfred
A1  - Kahmann, Stephanie Lucina
A1  - Wegmann, Kilian
T1  - Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 148
EP  - 149
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Gueven, H.
A1  - Lach, M.
A1  - Styczen, J.
T1  - Proton- and neutron h 11/2 exitations in ¹⁴¹ Eu
JF  - Annual report 1987 / Kernforschungsanlage Jülich Institut für Kernphysik / Grümmer, F. (Hrsg.) . - (Spezielle Berichte der Kernforschungsanlage Jülich ; 442)
Y1  - 1988
SP  - 43
PB  - Verlag des Forschungszentrums Jülich
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Gueven, H.
A1  - Julin, R.
A1  - Lach, M
T1  - Proton- and neutron H 11/2 excitations in 63 141 Eu 78
JF  - Zeitschrift für Physik / A, Hadrons and nuclei. 330 (1988), H. 4
Y1  - 1988
SN  - 1431-5831
N1  - 2. ISSN: 0340-2193 ; 3. ISSN 0930-1151 ; 4. ISSN 0939-7922
SP  - 437
EP  - 438
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Zerlin, Kay
A1  - Temiz Artmann, Aysegül
A1  - Engels, S.
T1  - Protein dynamics in thermosensation
JF  - Regenerative medicine. 2 (2007), H. 5
Y1  - 2007
SN  - 1746-0751
N1  - Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany
SP  - 533
EP  - 533
ER  - 
TY  - CHAP
A1  - Savitskaya, Irina S.
A1  - Kistaubayeva, Aida S.
A1  - Akimbekov, Nuraly
A1  - Digel, Ilya
A1  - Shokatayeva, Dina
A1  - Zhubanova, Azhar Achmet
T1  - Prospective Use of Probiotics Immobilized on Sorbents with Nanostructured Surfaces
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - Activated carbons are known as excellent adsorbents. Their applications include the adsorptive removal of color, odor, taste, undesirable organic and inorganic pollutants from drinking and waste water; air purification in inhabited spaces; purification of many chemicals, pharmaceutical products and many others. This chapter elucidates the role of normal microflora in the maintenance of human health and presents materials on possible clinical displays of microecological infringements and ways of their correction. It presents new developments concerning new probiotics with immobilized Lactobacillus and Bacillus. The chapter considers the mechanisms of the intestine disbacteriosis correction by sorbed probiotics. It demonstrates the advantages and creation prospects of immobilized probiotics developed on the basis of carbonized rice husk. There are great prospects for the development of medical biotechnology due to use of carbon sorbents with a nanostructured surface. Microbial communities form a biocenosis of the biotope and together with the host organism create permanent or temporary ecosystems.
Y1  - 2020
SN  - 978-981-4800-27-3
U6  - http://dx.doi.org/10.1201/9780429428647-12
SP  - 229
EP  - 267
PB  - Jenny Stanford Publishing
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Neskakis, A.
A1  - Lieder, R. M.
A1  - Beuscher, H.
T1  - Properties of side bands observed in ¹⁸⁰ Os
JF  - Zeitschrift für Physik / A, Hadrons and nuclei. 304 (1982), H. 3
Y1  - 1982
SN  - 1431-5831
N1  - 2. ISSN: 0340-2193 ; 3. ISSN 0930-1151 ; 4. ISSN 0939-7922
SP  - 277
EP  - 278
ER  - 
TY  - JOUR
A1  - Hillen, Walter
T1  - Properties of hadron final states in e+e− annihilation at 13 GeV and 17 GeV center of mass energies. TASSO Collaboration
JF  - Physics Letters B. 83 (1979), H. 2
Y1  - 1979
SN  - 0370-2693
SP  - 261
EP  - 266
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
A1  - Ruch, Ernst
T1  - Proof of the Mixing Theorem for Statistical Systems in Classical Physics. Ruch, Ernst; Stulpe, Werner
JF  - Acta Applicandae Mathematicae. 53 (1998), H. 3
Y1  - 1998
SN  - 1572-9036
SP  - 329
EP  - 352
ER  - 
TY  - JOUR
A1  - Jiminez German, Salvador
A1  - Behbahani, Mehdi
A1  - Miettinen, Susanna
A1  - Grijpma, Dirk W.
A1  - Haimi, Suvi P.
T1  - Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes
JF  - Macromolecular symposia
Y1  - 2013
SN  - 0258-0322
VL  - Vol. 334
IS  - Iss. 1
SP  - 133
EP  - 142
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
T1  - Projection
JF  - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.
Y1  - 2009
SN  - 978-3-540-70622-9
SP  - 497
EP  - 499
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hillen, Walter
T1  - Production and properties of the τ-lepton in e+e− annihilation at C.M. energies from 12 to 31.6 GeV. TASSO Collaboration
JF  - Physics Letters B. 92 (1980), H. 1-2
Y1  - 1980
SN  - 0370-2693
SP  - 199
EP  - 205
ER  - 
TY  - JOUR
A1  - Kopp, Alexander
A1  - Schmeets, Ralf
A1  - Gosau, Martin
A1  - Friedrich, Reinhard E.
A1  - Fuest, Sandra
A1  - Behbahani, Mehdi
A1  - Barbeck, Mike
A1  - Rutkowski, Rico
A1  - Burg, Simon
A1  - Kluwe, Lan
A1  - Henningsen, Anders
T1  - Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application
JF  - In Vivo
Y1  - 2019
U6  - http://dx.doi.org/10.21873/invivo.11536
SN  - 1791-7549
VL  - 33
IS  - 3
SP  - 757
EP  - 762
ER  - 
TY  - CHAP
A1  - Staat, Manfred
T1  - Problems and chances for probabilistic fracture mechanics in the analysis of steel pressure boundary reliability. - Überarb. Ausg.
N2  - In: Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in Jülich, 21-24 November 1994. - Vienna , 1996. - Seite: 43 - 55 IAEA-TECDOC-920 Abstract: It is shown that the difficulty for probabilistic fracture mechanics (PFM) is the general problem of the high reliability of a small population. There is no way around the problem as yet. Therefore what PFM can contribute to the reliability of steel pressure boundaries is demon­strated with the example of a typical reactor pressure vessel and critically discussed. Although no method is distinguishable that could give exact failure probabilities, PFM has several addi­tional chances. Upper limits for failure probability may be obtained together with trends for design and operating conditions. Further, PFM can identify the most sensitive parameters, improved control of which would increase reliability. Thus PFM should play a vital role in the analysis of steel pressure boundaries despite all shortcomings.
KW  - Bruchmechanik
KW  - probabilistic fracture mechanics
KW  - PFM
Y1  - 2006
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Problems and Chances for Probabilistic Fracture Mechanics in the Analysis of Steel Pressure Boundary Reliability
JF  - Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in Jülich, 21-24 November 1994
Y1  - 1996
N1  - IAEA-TECDOC-920 ; Onlinezugriff erfolgt auf die überarb. Ausg. 2006
SP  - 43
EP  - 55
CY  - Vienna
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Pourshahidi, Mohammad Ali
A1  - Shalaby, Ahmed
A1  - Krause, Hans-Joachim
T1  - Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation
JF  - Journal of Magnetism and Magnetic Materials
N2  - Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles’ magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning  nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing.
Y1  - 2022
U6  - http://dx.doi.org/10.1016/j.jmmm.2022.169965
SN  - 0304-8853
VL  - 563
IS  - In progress, Art. No. 169965
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Kern, Alexander
A1  - Dikta, Gerhard
T1  - Probability of damage of electrical and electronic systems due to indirect lightning flashes - investigation of data from German insurance companies
N2  - In the presented paper data collected from the field related to damage statistics of electrical and electronic apparatus in household are reported and investigated. These damages (total number approx. 74000 cases), registered by five German insurance companies in 2005 and 2006, were adviced by customers as caused by lightning overvoltages. With the use of stochastical methods it is possible, to reasses the collected data and to distinguish between cases, which are with high probability caused by lightning overvoltages, and those, which are not. If there was an indication for a direct strike, this case was excluded, so the focus was only on indirect lightning flashes, i.e. only flashes to ground near the structure and flashes to or nearby an incoming service line were investigated. The data from the field contain the location of damaged apparatus (residence of the policy holder) and the distances of the nearest cloud-to-ground stroke to the location of the damage registered by the German lightning location network BLIDS at the date of damage. The statistical data along with some complementary numerical simulations allow to verify the correspondence of the Standards rules used for IEC 62305-2 with the field data and to define some correction needs. The results could lead to a better understanding whether a damage reported to an insurance company is really caused by indirect lightning, or not.
KW  - Blitzschutz
KW  - lightning flash
Y1  - 2009
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Heitzer, M.
T1  - Probabilistic limit and shakedown problems
JF  - Numerical Methods for Limit and Shakedown Analysis. Deterministic and Probabilistic Approach. NIC Series Vol. 15 / Ed. by Staat, M; Heitzer, M.
Y1  - 2003
SN  - 3-00-010001-6
SP  - 217
EP  - 268
PB  - John von Neumann Institute for Computing (NIC)
CY  - Jülich
ER  - 
TY  - CHAP
A1  - Staat, Manfred
A1  - Heitzer, Michael
ED  - Staat, Manfred
ED  - Heitzer, Michael
T1  - Probabilistic limit and shakedown problems
T2  - Numerical methods for limit and shakedown analysis. Deterministic and probabilistic problems
Y1  - 2003
SN  - 3-00-010001-6
N1  - NIC Series
VL  - 15
SP  - 217
EP  - 268
PB  - John von Neumann Institute for Computing (NIC)
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Tran, Thanh Ngoc
A1  - Kreißig, R.
A1  - Staat, Manfred
T1  - Probabilistic limit and shakedown analysis of thin plates and shells
JF  - Structural safety. 31 (2009), H. 1
Y1  - 2009
SN  - 0167-4730
SP  - 1
EP  - 18
PB  - -
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Probabilistic assessment of the fracture mechanics behaviour of an HTR-module primary circuit pressure boundary
JF  - Nuclear Engineering and Design. 160 (1996), H. 1-2
Y1  - 1996
SN  - 0029-5493
SP  - 221
EP  - 236
ER  - 
TY  - JOUR
A1  - Digel, Ilya
T1  - Primary thermosensory events in cells
JF  - Transient receptor potential channels / Md. Shahidul Islam, ed.
Y1  - 2011
SN  - 978-94-007-0264-6
N1  - (Advances in experimental medicine and biology ; 704)
SP  - 451
EP  - 468
PB  - Springer
CY  - Dordrecht [u.a.]
ER  - 
TY  - CHAP
A1  - Abel, Alexander
A1  - Pérez-Viana, Daniel
A1  - Ciritsis, Bernard
A1  - Staat, Manfred
ED  - Erni, Daniel
ED  - Fischerauer, Alice
ED  - Himmel, Jörg
ED  - Seeger, Thomas
ED  - Thelen, Klaus
T1  - Prevention of femur neck fractures through femoroplasty
T2  - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West
Y1  - 2017
SN  - 978-3-9814801-9-1
U6  - http://dx.doi.org/10.17185/duepublico/43984
N1  - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017
SP  - 114
EP  - 115
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Rausch, Valentin
A1  - Kahmann, Stephanie Lucina
A1  - Baltschun, Christoph
A1  - Staat, Manfred
A1  - Müller, Lars P.
A1  - Wegmann, Kilian
T1  - Pressure distribution to the distal biceps tendon at the radial tuberosity: a biomechanical study
JF  - The Journal of Hand Surgery
N2  - Purpose
Mechanical impingement at the narrow radioulnar space of the tuberosity is believed to be an etiological factor in the injury of the distal biceps tendon. The aim of the study was to compare the pressure distribution at the proximal radioulnar space between 2 fixation techniques and the intact state.

Methods
Six right arms and 6 left arms from 5 female and 6 male frozen specimens were used for this study. A pressure transducer was introduced at the height of the radial tuberosity with the intact distal biceps tendon and after 2 fixation methods: the suture-anchor and the cortical button technique. The force (N), maximum pressure (kPa) applied to the radial tuberosity, and the contact area (mm²) of the radial tuberosity with the ulna were measured and differences from the intact tendon were detected from 60° supination to 60° pronation in 15° increments with the elbow in full extension and in 45° and 90° flexion of the elbow.

Results
With the distal biceps tendon intact, the pressures during pronation were similar regardless of extension and flexion and were the highest at 60° pronation with 90° elbow flexion (23.3 ± 53.5 kPa). After repair of the tendon, the mean peak pressure, contact area, and total force showed an increase regardless of the fixation technique. Highest peak pressures were found using the cortical button technique at 45° flexion of the elbow and 60° pronation. These differences were significantly different from the intact tendon. The contact area was significantly larger in full extension and 15°, 30°, and 60° pronation using the cortical button technique.

Conclusions
Pressures on the distal biceps tendon at the radial tuberosity increase during pronation, especially after repair of the tendon.

Clinical relevance
Mechanical impingement could play a role in both the etiology of primary distal biceps tendon ruptures and the complications occurring after fixation of the tendon using certain techniques.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.jhsa.2020.01.006
SN  - 0363-5023
VL  - 45
IS  - 8
SP  - 776.e1
EP  - 776.e9
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - INPR
A1  - Bornheim, Tobias
A1  - Niklas, Grieger
A1  - Blaneck, Patrick Gustav
A1  - Bialonski, Stephan
T1  - Preprint: Speaker attribution in German parliamentary debates with QLoRA-adapted large language models
T2  - Journal for Language Technology and Computational Linguistics
N2  - The growing body of political texts opens up new opportunities for rich insights into political dynamics and ideologies but also increases the workload for manual analysis. Automated speaker attribution, which detects who said what to whom in a speech event and is closely related to semantic role labeling, is an important processing step for computational text analysis. We study the potential of the large language model family Llama 2 to automate speaker attribution in German parliamentary debates from 2017-2021. We fine-tune Llama 2 with QLoRA, an efficient training strategy, and observe our approach to achieve competitive performance in the GermEval 2023 Shared Task On Speaker Attribution in German News Articles and Parliamentary Debates. Our results shed light on the capabilities of large language models in automating speaker attribution, revealing a promising avenue for computational analysis of political discourse and the development of semantic role labeling systems.
Y1  - 2023
U6  - http://dx.doi.org/10.48550/arXiv.2309.09902
N1  - Veröffentlichte Version verfügbar unter: https://doi.org/10.21248/jlcl.37.2024.244
ER  - 
TY  - INPR
A1  - Ringers, Christa
A1  - Bialonski, Stephan
A1  - Solovev, Anton
A1  - Hansen, Jan N.
A1  - Ege, Mert
A1  - Friedrich, Benjamin M.
A1  - Jurisch-Yaksi, Nathalie
T1  - Preprint: Local synchronization of cilia and tissue-scale cilia alignment are sufficient for global metachronal waves
T2  - bioRxiv
N2  - Motile cilia are hair-like cell extensions present in multiple organs of the body. How cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine here experiments, novel analysis tools, and theory to address this knowledge gap. We investigate collective dynamics of cilia in the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Despite the fact that synchronization is local only, we observed global patterns of traveling metachronal waves across the multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right nose, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment are sufficient to generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping.
Y1  - 2021
U6  - http://dx.doi.org/10.1101/2021.11.23.469646
N1  - Veröffentlicht in eLife 12:e77701 (https://doi.org/10.7554/eLife.77701).
ER  - 
TY  - INPR
A1  - Grieger, Niklas
A1  - Mehrkanoon, Siamak
A1  - Bialonski, Stephan
T1  - Preprint: Data-efficient sleep staging with synthetic time series pretraining
T2  - arXiv
N2  - Analyzing electroencephalographic (EEG) time series can be challenging, especially with deep neural networks, due to the large variability among human subjects and often small datasets. To address these challenges, various strategies, such as self-supervised learning, have been suggested, but they typically rely on extensive empirical datasets. Inspired by recent advances in computer vision, we propose a pretraining task termed "frequency pretraining" to pretrain a neural network for sleep staging by predicting the frequency content of randomly generated synthetic time series. Our experiments demonstrate that our method surpasses fully supervised learning in scenarios with limited data and few subjects, and matches its performance in regimes with many subjects. Furthermore, our results underline the relevance of frequency information for sleep stage scoring, while also demonstrating that deep neural networks utilize information beyond frequencies to enhance sleep staging performance, which is consistent with previous research. We anticipate that our approach will be advantageous across a broad spectrum of applications where EEG data is limited or derived from a small number of subjects, including the domain of brain-computer interfaces.
Y1  - 2024
ER  - 
TY  - JOUR
A1  - Khodaverdi, M.
A1  - Pauly, F.
A1  - Schroder, G.
A1  - Ziemons, Karl
A1  - Sievering, R.
A1  - Halling, H.
T1  - Preliminary studies of a micro-CT for a combined small animal PET/CT scanner
JF  - 2001 IEEE Nuclear Science Symposium Conference Record, Vol. 3
N2  - We are developing an X-ray computed tomography (CT) system which will be combined with a high resolution animal PET system. This permits acquisition of both molecular and anatomical images in a single machine. In particular the CT will also be utilized for the quantification of the animal PET data by providing accurate data for attenuation correction. A first prototype has been built using a commercially available plane silicon diode detector. A cone-beam reconstruction provides the images using the Feldkamp algorithm. First measurements with this system have been performed on a mouse. It could be shown that the CT setup fulfils all demands for a high quality image of the skeleton of the mouse. It is also suited for soft tissue measurements. To improve contrast and resolution and to acquire the X-ray energy further development of the system, especially the use of semiconductor detectors and iterative reconstruction algorithms are planned.
Y1  - 2002
SN  - 1082-3654
SP  - 1605
EP  - 1606
ER  - 
TY  - CHAP
A1  - Knott, Thomas C.
A1  - Sofronia, Raluca E.
A1  - Gerressen, Marcus
A1  - Law, Yuen
A1  - Davidescu, Arjana
A1  - Savii, George G.
A1  - Gatzweiler, Karl-Heinz
A1  - Staat, Manfred
A1  - Kuhlen, Torsten W.
T1  - Preliminary bone sawing model for a virtual reality-based training simulator of bilateral sagittal split osteotomy
T2  - Biomedical simulation : 6th International Symposium, ISBMS 2014, Strasbourg, France, October 16-17, 2014 : proceedings (Lecture notes in computer science : vol. 8789)
N2  - Successful bone sawing requires a high level of skill and experience, which could be gained by the use of Virtual Reality-based simulators. A key aspect of these medical simulators is realistic force feedback. The aim of this paper is to model the bone sawing process in order to develop a valid training simulator for the bilateral sagittal split osteotomy, the most often applied corrective surgery in case of a malposition of the mandible. Bone samples from a human cadaveric mandible were tested using a designed experimental system. Image processing and statistical analysis were used for the selection of four models for the bone sawing process. The results revealed a polynomial dependency between the material removal rate and the applied force. Differences between the three segments of the osteotomy line and between the cortical and cancellous bone were highlighted.
KW  - Bone sawing
KW  - virtual reality
KW  - training simulator
Y1  - 2014
SN  - 978-3-319-12057-7 (Online)
SN  - 978-3-319-12056-0 (Print)
U6  - http://dx.doi.org/10.1007/978-3-319-12057-7_1
SP  - 1
EP  - 10
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Preface of the Special Issue of I3S 2005 in Jülich (Germany)
N2  - International Symposium on Sensor Science, I3S 2005 <3; 2005; Juelich, Germany> In: Sensors 2006, 6, 260-261 ISSN 1424-8220
KW  - Biosensor
KW  - I3S 2005
KW  - International Symposium on Sensor Science
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1365
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Doll, Theodor
A1  - Wagner, Patrick
T1  - Preface / Doll, Theodor ; Wagner, Patrick ; Schöning, Michael J.
JF  - physica status solidi (a) . 206 (2009), H. 3
Y1  - 2009
SN  - 1862-6319
N1  - Special Issue: Engineering of Functional Interfaces (EnFI 08)
SP  - 389
EP  - 390
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Shasha, Carolyn
A1  - Teeman, Eric
A1  - Slabu, Iona
A1  - Krishnan, Kannan M.
T1  - Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic Néel-Brown Langevin simulation
JF  - Journal of Magnetism and Magnetic Materials
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.jmmm.2018.09.041
SN  - 0304-8853
VL  - 471
IS  - 1
SP  - 450
EP  - 456
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schelthoff, Christof
A1  - Basermann, Achim
A1  - Reichel, Björn
T1  - Preconditioned CG methods for sparse matrices on massively parallel machines / Basermann, A. ; Reichel, B. ; Schelthoff, C.
JF  - Parallel Computing. 23 (1997), H. 3
Y1  - 1997
SN  - 0167-8191
SP  - 381
EP  - 398
ER  - 
TY  - JOUR
A1  - Yoshinobu, T.
A1  - Ui, Y.
A1  - Iwasaki, H.
A1  - Näther, Niko
A1  - Koudelka-Hep, M.
A1  - Schöning, Michael Josef
T1  - Potentiometric imaging in a microfluidic channel
JF  - Biomedizinische Technik. 49 (2004), H. 2
Y1  - 2004
SN  - 0932-4666
SP  - 998
EP  - 999
ER  - 
TY  - JOUR
A1  - Jayaraman, Chandrasekaran
A1  - Mummidisetty, Chaitanya Krishna
A1  - Loesch, Alexandra
A1  - Kaur, Sandi
A1  - Hoppe-Ludwig, Shenan
A1  - Staat, Manfred
A1  - Jayaraman, Arun
T1  - Postural and metabolic benefits of using a forearm support walker in older adults with impairments
JF  - Archives of Physical Medicine and Rehabilitation
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.apmr.2018.10.001
SN  - 0003-9993
VL  - Volume 100
IS  - Issue 4
SP  - 638
EP  - 647
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Kozlova, Tatiana V.
A1  - Lanzl, Ines M.
T1  - Postoperative aqueous outflow in the human eye after glaucoma filtration surgery: biofluidmechanical considerations
JF  - Biomedizinische Technik = Biomedical Engineering
Y1  - 2009
SN  - 1862-278X
VL  - 54
IS  - 1
SP  - 14
EP  - 22
PB  - -
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Cherstvy, A.
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Possibilities and limitations of label-free detection of DNA hybridization with field-effect-based devices
JF  - Sensors and Actuators B. 111-112 (2005)
Y1  - 2005
SN  - 0925-4005
N1  - Eurosensors XVIII 2004 — The 18th European Conference on Solid-State Transducers
SP  - 470
EP  - 480
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Cherstvy, A.
A1  - Schöning, Michael Josef
T1  - Possibilities and limitations of label-free detection of DNA hybridization with field-effect based devices
JF  - Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].
Y1  - 2004
SN  - 88-7621-282-5
N1  - Eurosensors ; (18, 2004, Roma)
SP  - 173
EP  - 176
CY  - Roma
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Lieder, R. M.
A1  - Neskakis, A
T1  - Positive parity bands in ¹⁹⁵,¹⁹⁷ Tl
JF  - Proceedings of the International Conference on Nuclear Structure : Tokyo, Sept. 5 - 10, 1977 / ed. by T. Marumori. - Journal of the Physical Society of Japan ; Vol. 44, 1978 : Suppl.
Y1  - 1978
N1  - International Conference on Nuclear Structure <1977, Tokyo>
SP  - 441
PB  - Physical Soc. of Japan
CY  - Tokyo
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Protic, D.
A1  - Krings, T.
A1  - Niessen, S.
T1  - Position-Sensitive Si(Li) Transmission Detectors for the EXL-Experiments at GSI-Darmstadt.
JF  - Scientific Report / GSi Gesellschaft für Schwerionenforschung, Darmstadt. 2007 (2007), H. 1
Y1  - 2007
SN  - 0174-0814
N1  - Fair-Experiments-31; GSI Report 2007-1, June 2007 ; GSI Scientific Report 2006
SP  - 33
ER  - 
TY  - JOUR
A1  - Yoshinobu, T.
A1  - Schöning, Michael Josef
A1  - Otto, R.
A1  - Furuichi, K.
A1  - Mourzina, Y.
A1  - Ermelenko, Y.
A1  - Iwasaki, H.
T1  - Portable light-addressable potentiometric sensor (LAPS) for multisensor applications
JF  - Sensors and Actuators B. 95 (2003), H. 1-3
Y1  - 2003
SN  - 0925-4005
SP  - 352
EP  - 356
ER  - 
TY  - JOUR
A1  - Yoshinobu, T.
A1  - Schöning, Michael Josef
A1  - Otto, R.
A1  - Furuichi, K.
A1  - Mourzina, Yu
A1  - Ermelenko, Yu
A1  - Iwasaki, I.
T1  - Portable light-addressable potentiometric sensor (LAPS) for multisensor applications
JF  - Book of abstracts / ed. by J. Saneistr.
Y1  - 2002
SN  - 80-01-02576-4
N1  - Eurosensors ; (16, 2002, Praha)
SP  - 898
EP  - 901
PB  - Czech Technical University, Faculty of Electrical Engineering, Department of Measurement
CY  - Prague
ER  - 
TY  - JOUR
A1  - Thust, Marion
A1  - Schöning, Michael Josef
A1  - Frohnhoff, S.
A1  - Arens-Fischer, R.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Porous silicon as a substrate material for potentiometric biosensors
JF  - Measurement Science and Technology
Y1  - 1996
U6  - http://dx.doi.org/10.1088/0957-0233/7/1/003
VL  - 7
IS  - 1
SP  - 26
EP  - 29
ER  - 
TY  - JOUR
A1  - Ciritsis, Alexander
A1  - Horbach, Andreas
A1  - Staat, Manfred
A1  - Kuhl, Christiane K.
A1  - Kraemer, Nils Andreas
T1  - Porosity and tissue integration of elastic mesh implants evaluated in vitro and in vivo
JF  - Journal of Biomedical Materials Research: Part B:  Applied Biomaterials
N2  - Purpose
In vivo, a loss of mesh porosity triggers scar tissue formation and restricts functionality. The purpose of this study was to evaluate the properties and configuration changes as mesh deformation and mesh shrinkage of a soft mesh implant compared with a conventional stiff mesh implant in vitro and in a porcine model.

Material and Methods
Tensile tests and digital image correlation were used to determine the textile porosity for both mesh types in vitro. A group of three pigs each were treated with magnetic resonance imaging (MRI) visible conventional stiff polyvinylidene fluoride meshes (PVDF) or with soft thermoplastic polyurethane meshes (TPU) (FEG Textiltechnik mbH, Aachen, Germany), respectively. MRI was performed with a pneumoperitoneum at a pressure of 0 and 15 mmHg, which resulted in bulging of the abdomen. The mesh-induced signal voids were semiautomatically segmented and the mesh areas were determined. With the deformations assessed in both mesh types at both pressure conditions, the porosity change of the meshes after 8 weeks of ingrowth was calculated as an indicator of preserved elastic properties. The explanted specimens were examined histologically for the maturity of the scar (collagen I/III ratio).

Results
In TPU, the in vitro porosity increased constantly, in PVDF, a loss of porosity was observed under mild stresses. In vivo, the mean mesh areas of TPU were 206.8 cm2 (± 5.7 cm2) at 0 mmHg pneumoperitoneum and 274.6 cm2 (± 5.2 cm2) at 15 mmHg; for PVDF the mean areas were 205.5 cm2 (± 8.8 cm2) and 221.5 cm2 (± 11.8 cm2), respectively. The pneumoperitoneum-induced pressure increase resulted in a calculated porosity increase of 8.4% for TPU and of 1.2% for PVDF. The mean collagen I/III ratio was 8.7 (± 0.5) for TPU and 4.7 (± 0.7) for PVDF.

Conclusion
The elastic properties of TPU mesh implants result in improved tissue integration compared to conventional PVDF meshes, and they adapt more efficiently to the abdominal wall. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 827–833, 2018.
Y1  - 2018
U6  - http://dx.doi.org/10.1002/jbm.b.33877
SN  - 1552-4981
VL  - 106
IS  - 2
SP  - 827
EP  - 833
PB  - Wiley
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Maggakis-Kelemen, Christina
A1  - Digel, Ilya
A1  - Artmann, Gerhard
T1  - Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility
JF  - Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1
Y1  - 2005
SP  - 324
EP  - 326
ER  - 
TY  - JOUR
A1  - Forst, Thomas
A1  - Karagiannis, E.
A1  - Lübben, G.
A1  - Hohberg, C.
A1  - Schöndorf, T.
A1  - Dikta, Gerhard
A1  - Drexler, M.
A1  - Morcos, M.
A1  - Dänschel, W.
A1  - Borchert, M.
A1  - Pfützner, A.
T1  - Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease
JF  - Atherosclerosis. 197 (2008), H. 1
Y1  - 2008
U6  - http://dx.doi.org/10.1016/j.atherosclerosis.2007.05.006
SN  - 0021-9150
SP  - 311
EP  - 317
ER  - 
TY  - JOUR
A1  - Kloock, Joachim P.
A1  - Moreno, Lia
A1  - Bratov, A.
A1  - Huachupoma, S.
A1  - Xu, J.
A1  - Wagner, Torsten
A1  - Yoshinobu, T.
A1  - Ermolenko, Y.
A1  - Vlasov, Y. G.
A1  - Schöning, Michael Josef
T1  - PLD-prepared cadmium sensors based on chalcogenide glasses —ISFET, LAPS and &#956;ISE semiconductor structures
JF  - Sensors and Actuators B: Chemical. 118 (2006), H. 1-2
Y1  - 2006
SN  - 0925-4005
N1  - Eurosensors XIX - Eurosensors XIX - The 19th European Conference on Solid-State Transducers
SP  - 149
EP  - 155
ER  - 
TY  - JOUR
A1  - Michael, Hackl
A1  - Mayer, Katharina
A1  - Weber, Mareike
A1  - Staat, Manfred
A1  - van Riet, Roger
A1  - Burkhart, Klau Josef
A1  - Müller, Lars Peter
A1  - Wegmann, Kilian
T1  - Plate osteosynthesis of proximal ulna fractures : a biomechanical micromotion analysis
JF  - The journal of hand surgery
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.jhsa.2017.05.014
SN  - 0363-5023
VL  - 42
IS  - 10
SP  - 834.e1
EP  - 834.e7
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Karamanidis, Kiros
A1  - Mademli, Lida
A1  - Albracht, Kirsten
T1  - Plasticity of the human tendon to short and long-term mechanical loading
JF  - Exercise and Sport Sciences Reviews
Y1  - 2009
U6  - http://dx.doi.org/10.1097/JES.0b013e31819c2e1d
SN  - 1538-3008
VL  - 37
IS  - 2
SP  - 66
EP  - 72
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Peper, Andreas
A1  - Bierbaum, Stefanie
A1  - Albracht, Kirsten
T1  - Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain
JF  - Journal of Biomechanics
N2  - The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47%), and the other leg at high tendon strain magnitude (4.72±1.08%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon–aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon–aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.
Y1  - 2010
U6  - http://dx.doi.org/10.1016/j.jbiomech.2010.08.014
SN  - 0021-9290
VL  - 43
IS  - 16
SP  - 3073
EP  - 3079
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Plastic collapse analysis of longitudinally flawed pipes and vessels
JF  - Nuclear Engineering and Design. 234 (2004), H. 1-3
Y1  - 2004
SN  - 0029-5493
SP  - 25
EP  - 43
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Plastic collapse analysis of longitudinally flawed pipes and vessels
N2  - Improved collapse loads of thick-walled, crack containing pipes and vessels are suggested. Very deep cracks have a residual strength which is better modelled by a global limit load. In all burst tests, the ductility of pressure vessel steels was sufficiently high whereby the burst pressure could be predicted by limit analysis with no need to apply fracture mechanics. The relative prognosis error increases however, for long and deep defects due to uncertainties of geometry and strength data.
KW  - Druckbehälter
KW  - Stahl
KW  - Druckbelastung
KW  - Druckbeanspruchung
KW  - Rohr
KW  - Rohrbruch
KW  - Druckbehälter
KW  - Stahl
KW  - Druckbelastung
KW  - Druckbeanspruchung
KW  - Rohrbruch
KW  - Fehlerstellen
KW  - pipes
KW  - vessels
KW  - load limit
KW  - burst tests
KW  - burst pressure
KW  - flaw
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Bäumler, H.
A1  - Voigt, A.
A1  - Mitlöhner, R. [u.a.]
T1  - Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. Bäumler, H., Artmann, Gerhard Michael; Voigt, A., Mitlöhner, R., Neu, B., Kiesewetter, H.
JF  - Journal of Microencapsulation. 17 (2000), H. 5
Y1  - 2000
SN  - 1464-5246
SP  - 651
EP  - 655
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - Plasma-generated cluster ions' effects on indoor microflora : [abstract]
N2  - Recently, SHARP corporation has developed the world’s first "Plasma Cluster Ions® (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new Plasma Cluster Device releases positive and negative ions into the air, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. In the past, phenomenological tests on the efficacy of the PCI air purification technology on microbial cells have been conducted. In most cases, it has been shown that PCI demonstrated strongly pronounced killing effects on microorganisms. However, the particular mechanisms of PCI action still have to be uncovered.
KW  - Clusterion
KW  - Raumluft
KW  - Luftreiniger
KW  - Plasmacluster ion technology
KW  - Air purification
Y1  - 2003
ER  - 
TY  - CHAP
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Nojima, H.
T1  - Plasma cluster ions (PCI) influence on microbial cells viability : [abstract]
N2  - Recently, SHARP corporation has developed the world’s first “Plasma Cluster Ions (PCI)” air purification technology, which uses plasma discharge to generate cluster ions. The new plasma cluster device releases into the air positive and negative ions, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. A lot of phenomenological tests of the PCI air purification technology on microbial cells have been conducted. And, in most cases, it has been shown that PCI demonstrate strongly pronounced killing effect. Although, the particular mechanisms of PCI action are still not evident. We studied variations in resistance to PCI among gram-positive airborne microorganisms, as well as some dose-dependent, spatial, cultural and biochemical properties of PCI action in respect of Staphylococcus spp, Enterococcus spp, Micrococcus spp.
KW  - Clusterion
KW  - Raumluft
KW  - Luftreiniger
KW  - Plasmacluster ion technology
KW  - Air purification
Y1  - 2003
ER  - 
TY  - JOUR
A1  - Streun, M.
A1  - Beer, S.
A1  - Hombach, T.
A1  - Jahnke, S.
A1  - Khodaverdi, M.
A1  - Larue, H.
A1  - Minwuyelet, S.
A1  - Parl, C.
A1  - Roeb, G.
A1  - Schurr, U.
A1  - Ziemons, Karl
T1  - PlanTIS: A positron emission tomograph for imaging 11C transport in plants
JF  - 2007 IEEE Nuclear Science Symposium Conference Record, Vol. 6
N2  - Plant growth and transport processes are highly dynamic. They are characterized by plant-internal control processes and by strong interactions with the spatially and temporally varying environment. Analysis of structure- function relations of growth and transport in plants will strongly benefit from the development of non-invasive techniques. PlanTIS (Plant Tomographic Imaging System) is designed for non-destructive 3D-imaging of positron emitting radiotracers. It will permit functional analysis of the dynamics of carbon distribution in plants including bulky organs. It will be applicable for screening transport properties of plants to evaluate e.g. temperature adaptation of genetically modified plants. PlanTIS is a PET scanner dedicated to monitor the dynamics of the 11C distribution within a plant while or after assimilation of 11CO2. Front end electronics and data acquisition architecture of the scanner are based on the ClearPETTM system [1]. Four detector modules form one of two opposing detector blocks. Optionally, a hardware coincidence detection between the blocks can be applied. In general the scan duration is rather long (~ 1 hour) compared to the decay time of 11C (20 min). As a result the count rates can vary over a wide range and accurate dead time correction is necessary.
Y1  - 2008
SN  - 1082-3654
SP  - 4110
EP  - 4112
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Kramer, F.
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bratov, A.
A1  - Abramova, N.
A1  - Schöning, Michael Josef
T1  - Planar and 3D interdigitated electrodes for biosensing applications: The impact of a dielectric barrier on the sensor properties
JF  - Physica Status Solidi (A) - Applications and Materials Science
N2  - Planar and three-dimensional (3D) interdigitated electrodes (IDE) with electrode digits separated by an insulating barrier of different heights were electrochemically characterized and compared in terms of their sensing properties. Due to the impact of the surface resistance, both types of IDE structures display a non-linear behavior in low-ionic strength solutions. The experimental data were fitted to an electrical equivalent circuit and interpreted taking into account the surface-charge-governed properties. The effect of a charged polyelectrolyte layer electrostatically assembled onto the sensor surface on the surface resistance in solutions with different KCl concentration is studied. In case of the same electrode footprint, 3D-IDEs show a larger cell constant and a higher sensitivity to molecular adsorption than that of planar IDEs. The obtained results demonstrate the potential of 3D-IDEs as a new transducer structure for a direct label-free sensing of charged molecules.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/pssa.201330416
SN  - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1357
EP  - 1363
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Kaminsky, Radoslav
A1  - Dumont, K.
A1  - Weber, Hans-Joachim
A1  - Schroll, M.
A1  - Verdonck, P.
T1  - PIV validation of blood-heart valve leaflet interaction modelling
JF  - The International journal of artificial organs. 30 (2007), H. 7
Y1  - 2007
SP  - 640
EP  - 648
PB  - -
ER  - 
TY  - BOOK
A1  - Weber, Hans-Joachim
A1  - Kaminsky, Radoslav
A1  - Kallweit, Stephan
A1  - Simons, Antoine
T1  - PIV measurements with high temporal resolution behind artificial heart valves
Y1  - 2005
N1  - International Symposium on Particle Image Velocimetry <6, 2005, Pasadena, Calif.>
ER  - 
TY  - JOUR
A1  - Bialonski, Stephan
A1  - Caron, David A.
A1  - Schloen, Julia
A1  - Feudel, Ulrike
A1  - Kantz, Holger
A1  - Moorthi, Stefanie D.
T1  - Phytoplankton dynamics in the Southern California Bight indicate a complex mixture of transport and biology
JF  - Journal of Plankton Research
N2  - The stimulation and dominance of potentially harmful phytoplankton taxa at a given locale and time are determined by local environmental conditions as well as by transport to or from neighboring regions. The present study investigated the occurrence of common harmful algal bloom (HAB) taxa within the Southern California Bight, using cross-correlation functions to determine potential dependencies between HAB taxa and environmental factors, and potential links to algal transport via local hydrography and currents. A simulation study, in which Lagrangian particles were released, was used to assess travel times due to advection by prevailing ocean currents in the bight. Our results indicate that transport of some taxa may be an important mechanism for the expansion of their distributions into other regions, which was supported by mean travel times derived from our simulation study and other literature on ocean currents in the Southern California Bight. In other cases, however, phytoplankton dynamics were rather linked to local environmental conditions, including coastal upwelling events. Overall, our study shows that complex current patterns in the Southern California Bight may contribute significantly to the formation and expansion of HABs in addition to local environmental factors determining the spatiotemporal dynamics of phytoplankton blooms.
Y1  - 2016
U6  - http://dx.doi.org/10.1093/plankt/fbv122
SN  - 1464-3774
VL  - 38
IS  - 4
SP  - 1077
EP  - 1091
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Koshitz, I. N.
A1  - Svetlowa, O. V.
A1  - Zaseeva, M. V.
T1  - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part II Promising algorithms of practical sparing applications / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotliar
JF  - Glaukoma (2006)
Y1  - 2006
N1  - Original in Russisch
SP  - 51
EP  - 70
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Koshitz, I. N.
A1  - Svetlova, O. V.
A1  - Zaseeva, M. V.
T1  - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part I Initial theoretical presuppositions, hypotheses and facts / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotli
JF  - Glaukoma (2006)
Y1  - 2006
N1  - Original in Russisch
SP  - 35
EP  - 53
PB  - -
ER  - 
TY  - JOUR
A1  - Savitskaya, I. S.
A1  - Kistaubayeva, A. S.
A1  - Digel, Ilya
A1  - Shokatayeva, D. H.
T1  - Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials
JF  - Eurasian Chemico-Technological Journal
Y1  - 2017
U6  - http://dx.doi.org/10.18321/ectj670
SN  - 2522-4867
VL  - 19
IS  - 3
SP  - 255
EP  - 264
ER  - 
TY  - JOUR
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Staat, Manfred
T1  - Physical response of hyperelastic models for composite materials and soft tissues
JF  - Asia pacific journal on computational engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1186/s40540-015-0015-x
SN  - 2196-1166
VL  - 2
IS  - 3 (December 2015)
SP  - 1
EP  - 18
ER  - 
TY  - CHAP
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Staat, Manfred
T1  - Physical response of hyperelastic models for composite materials and soft tissues
T2  - Advances in Composite Material
Y1  - 2017
SN  - 978-1-61896-300-0 (Hardcover), 978-1-61896-299-7 (Paperback)
N1  - Chapter 5
PB  - Scientific Research Publishing
CY  - Wuhan
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zerlin, Kay
A1  - Digel, Ilya
A1  - Stadler, Andreas M.
T1  - Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA
JF  - Tissue Engineering. 13 (2007), H. 7
Y1  - 2007
SN  - 1076-3279
N1  - TERMIS-EU Meeting Abstracts London, UK September 4–7, 2007
SP  - 1778
EP  - 1778
ER  - 
TY  - JOUR
A1  - Murib, M. S.
A1  - Yeap, W. S.
A1  - Martens, D.
A1  - Liu, X.
A1  - Bienstman, P.
A1  - Fahlman, M.
A1  - Schöning, Michael Josef
A1  - Michiels, L.
A1  - Haenen, K.
A1  - Serpengüzel, A.
A1  - Wagner, Patrick
T1  - Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands
JF  - Sensors and actuators A: Physical
N2  - In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.sna.2014.11.024
SN  - 1873-3069 (E-Journal); 0924-4247 (Print)
VL  - 222
SP  - 212
EP  - 219
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Murib, Mohammed Sharif
A1  - Yeap, Weng-Siang
A1  - Martens, Daan
A1  - Bienstman, Peter
A1  - Ceuninck, Ward de
A1  - Grinsven, Bart van
A1  - Schöning, Michael Josef
A1  - Michiels, Luc
A1  - Haenen, Ken
A1  - Ameloot, Marcel
A1  - Serpengüzel, Ali
A1  - Wagner, Patrick
T1  - Photonic detection and characterization of DNA using sapphire microspheres
JF  - Journal of biomedical optics
N2  - A microcavity-based deoxyribonucleic acid (DNA) optical biosensor is demonstrated for the first time using synthetic sapphire for the optical cavity. Transmitted and elastic scattering intensity at 1510 nm are analyzed from a sapphire microsphere (radius 500  μm, refractive index 1.77) on an optical fiber half coupler. The 0.43 nm angular mode spacing of the resonances correlates well with the optical size of the sapphire sphere. Probe DNA consisting of a 36-mer fragment was covalently immobilized on a sapphire microsphere and hybridized with a 29-mer target DNA. Whispering gallery modes (WGMs) were monitored before the sapphire was functionalized with DNA and after it was functionalized with single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The shift in WGMs from the surface modification with DNA was measured and correlated well with the estimated thickness of the add-on DNA layer. It is shown that ssDNA is more uniformly oriented on the sapphire surface than dsDNA. In addition, it is shown that functionalization of the sapphire spherical surface with DNA does not affect the quality factor (Q≈104) of the sapphire microspheres. The use of sapphire is especially interesting because this material is chemically resilient, biocompatible, and widely used for medical implants.
Y1  - 2014
U6  - http://dx.doi.org/10.1117/1.JBO.19.9.097006
SN  - 1560-2281 (E-Journal); 1083-3668 (Print)
VL  - 19
IS  - 9
SP  - 097006
PB  - SPIE
CY  - Bellingham
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Nagamine Komesu, Cindy A.
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Photoelectrochemical enzymatic penicillin biosensor: A proof-of-concept experiment
JF  - Electrochemical Science Advances
N2  - Photoelectrochemical (PEC) biosensors are a rather novel type of biosensors thatutilizelighttoprovideinformationaboutthecompositionofananalyte,enablinglight-controlled multi-analyte measurements. For enzymatic PEC biosensors,amperometric detection principles are already known in the literature. In con-trast, there is only a little information on H+-ion sensitive PEC biosensors. Inthis work, we demonstrate the detection of H+ions emerged by H+-generatingenzymes, exemplarily demonstrated with penicillinase as a model enzyme on atitanium dioxide photoanode. First, we describe the pH sensitivity of the sensorand study possible photoelectrocatalytic reactions with penicillin. Second, weshow the enzymatic PEC detection of penicillin.
KW  - enzymatic biosensor
KW  - penicillin
KW  - penicillinase
KW  - photoelectrochemistry
KW  - titanium dioxide photoanode
Y1  - 2021
U6  - http://dx.doi.org/10.1002/elsa.202100131
SN  - 2698-5977
N1  - Corresponding auhtor: Michael J. Schöning
VL  - 2
IS  - 4
SP  - 1
EP  - 5
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T
A1  - Mourzina, Y.
A1  - Levichev, S.
A1  - Furuichi, K.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Photocurable membranes for ion-selective light-addressable potentiometric sensors
JF  - Sensors and Actuators B. 85 (2002), H. 1-2
Y1  - 2002
SN  - 0925-4005
SP  - 79
EP  - 85
ER  - 
TY  - JOUR
A1  - Arinkin, Vladimir
A1  - Digel, Ilya
A1  - Porst, Dariusz
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application
JF  - BMC bioinformatics
N2  - Background
True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN).

Results
Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm.

Conclusions
Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1% and reached 100% in one of the best ANN.
Y1  - 2014
U6  - http://dx.doi.org/10.1186/1471-2105-15-55
SN  - 1471-2105
VL  - 15
IS  - 55
SP  - 1
EP  - 8
ER  - 
TY  - JOUR
A1  - Jahnke, Siegfried
A1  - Roussel, Johanna
A1  - Hombach, Thomas
A1  - Kochs, Johannes
A1  - Fischbach, Andreas
A1  - Huber, Gregor
A1  - Scharr, Hanno
T1  - phenoSeeder - A robot system for automated handling and phenotyping of individual seeds
JF  - Plant physiology
N2  - The enormous diversity of seed traits is an intriguing feature and critical for the overwhelming success of higher plants. In particular, seed mass is generally regarded to be key for seedling development but is mostly approximated by using scanning methods delivering only two-dimensional data, often termed seed size. However, three-dimensional traits, such as the volume or mass of single seeds, are very rarely determined in routine measurements. Here, we introduce a device named phenoSeeder, which enables the handling and phenotyping of individual seeds of very different sizes. The system consists of a pick-and-place robot and a modular setup of sensors that can be versatilely extended. Basic biometric traits detected for individual seeds are two-dimensional data from projections, three-dimensional data from volumetric measures, and mass, from which seed density is also calculated. Each seed is tracked by an identifier and, after phenotyping, can be planted, sorted, or individually stored for further evaluation or processing (e.g. in routine seed-to-plant tracking pipelines). By investigating seeds of Arabidopsis (Arabidopsis thaliana), rapeseed (Brassica napus), and barley (Hordeum vulgare), we observed that, even for apparently round-shaped seeds of rapeseed, correlations between the projected area and the mass of seeds were much weaker than between volume and mass. This indicates that simple projections may not deliver good proxies for seed mass. Although throughput is limited, we expect that automated seed phenotyping on a single-seed basis can contribute valuable information for applications in a wide range of wild or crop species, including seed classification, seed sorting, and assessment of seed quality.
Y1  - 2016
U6  - http://dx.doi.org/10.1104/pp.16.01122
SN  - 0032-0889
VL  - 172
IS  - 3
SP  - 1358
EP  - 1370
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
A1  - Singer, Matthias
T1  - Phase-Space Representations of General Statistical Physical Theories. Singer, Matthias; Stulpe, Werner
JF  - Journal of Mathematical Physics. 33 (1992), H. 1
Y1  - 1992
SN  - 1089-7658
SP  - 131
EP  - 142
ER  - 
TY  - JOUR
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Kanoh, Shin`ichiro
A1  - Schöning, Michael Josef
T1  - Phase-mode operation of FDM-LAPS
JF  - Sensor letters
Y1  - 2011
SN  - 1546-1971
VL  - 9
IS  - 2
SP  - 691
EP  - 694
PB  - American Scientific Publishers
CY  - Stevenson Ranch, Calif.
ER  - 
TY  - JOUR
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Kanoh, Shin`ichiro
A1  - Schöning, Michael Josef
T1  - Phase-mode LAPS and its application to chemical imaging
JF  - Sensors and Actuators B: Chemical. 154 (2011), H. 1
Y1  - 2011
SN  - 1873-3077
SP  - 28
EP  - 32
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Buniatyan, Vahe V.
A1  - Abouzar, Maryam H.
A1  - Martirosyan, Norayr W.
A1  - Schubert, Jürgen
A1  - Gevorgian, Spartak
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - pH-sensitive properties of barium strontium titanate (BST) thin films prepared by pulsed laser deposition technique
JF  - Physica Status Solidi (A). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 824
EP  - 830
ER  - 
TY  - CHAP
A1  - Pijanowska, Dorota G.
A1  - Remiszewska, Elzbieta
T1  - pH-based detection of phenylalnine by potentiometric and colorimetric methods
N2  - In this paper, methods of sample preparation for potentiometric measurement of phenylalanine are presented. Basing on the spectrophotometric measurements of phenylalanine, the concentrations of reagents of the enzymatic reaction (10 mM L-Phe, 0,4 mM NAD+, 2U L-PheDH) were determined. Then, the absorption spectrum of the reaction product, NADH, was monitored (maximum peak at 340 nm). The results obtained by the spectrophotometric method were compared with the results obtained by the colourimetry, using pH indicators. The above-mentioned two methods will be used as references for potentiometric measurements of phenylalanine concentration.
KW  - Biosensor
KW  - Phenylalanine determination
KW  - enzymatic methods
KW  - pH-based biosensing
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1536
ER  - 
TY  - JOUR
A1  - Christiaens, P.
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Wagner, Torsten
A1  - Bijnens, N.
A1  - Williams, O. A.
A1  - Daenen, M.
A1  - Haenen, K.
A1  - Douthéret, O.
A1  - Haen, J. d´
A1  - Mekhalif, Z.
A1  - Schöning, Michael Josef
A1  - Wagner, P.
T1  - pH sensitivity of nanocrystalline diamond films
JF  - Physica status solidi (A). 204 (2007), H. 9
Y1  - 2007
SN  - 0031-8965
SP  - 2925
EP  - 2930
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
T1  - pH and ion sensitivity of a field-effect EIS (electrolyte-insulator-semiconductor) sensor covered with polyelectrolyte multilayers
JF  - Journal of Solid State Electrochemistry. 13 (2009), H. 1
Y1  - 2009
SN  - 1433-0768
N1  - This manuscript is an invited paper to the special issue on “Solid-state potentiometric sensors” (Guest editor: Johan Bobacka).
SP  - 115
EP  - 122
ER  - 
TY  - JOUR
A1  - Schäfer, Horst
A1  - Scholl, S.
A1  - Gerschütz, F.
A1  - Fischer, F. (u.a.)
T1  - Persistent Photoconductivity in Halogen-doped Cd1-X ZnX Te, Cd1-X MnX Te and Cd1-X-MgX -Te Layers
JF  - 22nd International Conference on the Physics of Semiconductors : Vancouver, Canada, August 15 - 19, 1994 / ed. David J. Lockwood
Y1  - 1995
SN  - 981-02-2021-9
SP  - 2423
EP  - 2426
PB  - World Scientific
CY  - Singapore [u.a.]
ER  - 
TY  - JOUR
A1  - Schäfer, Horst
A1  - Scholl, S.
A1  - Gerschütz, F.
A1  - Fischer, A. (u.a.)
T1  - Persistent Photoconductivity in CdTe-based  II-VI-Semiconductors
JF  - Solid State Communications. 91 (1994), H. 6
Y1  - 1994
SN  - 0038-1098
SP  - 491
EP  - 495
ER  - 
TY  - JOUR
A1  - Kuchler, Timon
A1  - Günthner, Roman
A1  - Ribeiro, Andrea
A1  - Hausinger, Renate
A1  - Streese, Lukas
A1  - Wöhnl, Anna
A1  - Kesseler, Veronika
A1  - Negele, Johanna
A1  - Assali, Tarek
A1  - Carbajo-Lozoya, Javier
A1  - Lech, Maciej
A1  - Adorjan, Kristina
A1  - Stubbe, Hans Christian
A1  - Hanssen, Henner
A1  - Kotliar, Konstantin
A1  - Haller, Berhard
A1  - Heemann, Uwe
A1  - Schmaderer, Christoph
T1  - Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
N2  - Background
Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians.

Methods
In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204).

Measurements and main results
PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42% ± 1.77% vs. 4.64% ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5–190.2] vs. 189.1 [179.4–197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8–0.9] vs. 0.88 [0.8–0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = − 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters.

Conclusion
Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management.
KW  - Endothelial dysfunction
KW  - Long COVID
KW  - Post-COVID-19 syndrome
KW  - retinal microvasculature
Y1  - 2023
U6  - http://dx.doi.org/10.1007/s10456-023-09885-6
N1  - Corresponding author: Christoph Schmaderer
VL  - 26
SP  - 547
EP  - 563
PB  - Springer Nature
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Amin, Rashid
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Lazarovici, Philip
A1  - Lelkes, Peter I.
T1  - Permeability of an In Vitro Model of Blood Brain Barrier (BBB)
JF  - 13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]
Y1  - 2009
SN  - 978-3-540-92841-6
N1  - IFMBE Proceedings ; 23, Track 1 ; ICBME 2008 3–6 December 2008 Singapore
SP  - 81
EP  - 84
ER  - 
TY  - CHAP
A1  - Savitskaya, Irina S.
A1  - Kistaubayeva, Aida S.
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Zhubanova, Azhar A.
T1  - Performance of Bio-Composite Carbonized Materials in Probiotic Applications
T2  - World Academy of Science, Engineering and Technology International Journal of Biotechnology and Bioengineering
Y1  - 2013
VL  - 7
IS  - 7
SP  - 685
EP  - 689
ER  - 
TY  - JOUR
A1  - Gutheil, Inge
A1  - Berg, Tommy
A1  - Grotendorst, Johannes
T1  - Performance Analysis of Parallel Eigensolvers of two Libraries on BlueGene/P
JF  - Journal of Mathematics and Systems Science
N2  - Many applications in computational science and engineering require the computation of eigenvalues and vectors of dense symmetric or Hermitian matrices. For example, in DFT (density functional theory) calculations on modern supercomputers 10% to 30% of the eigenvalues and eigenvectors of huge dense matrices have to be calculated. Therefore, performance and parallel scaling of the used eigensolvers is of upmost interest. In this article different routines of the linear algebra packages ScaLAPACK and Elemental for parallel solution of the symmetric eigenvalue problem are compared concerning their performance on the BlueGene/P supercomputer. Parameters for performance optimization are adjusted for the different data distribution methods used in the two libraries. It is found that for all test cases the new library Elemental which uses a two-dimensional element by element distribution of the matrices to the processors shows better performance than the old ScaLAPACK library which uses a block-cyclic distribution.
KW  - performance analysis
KW  - Elemental
KW  - ScaLAPACK
KW  - eigensolvers
KW  - Numerical linear algebra
Y1  - 2012
U6  - http://dx.doi.org/10.17265/2159-5291/2012.04.003
SN  - 2159-5291
VL  - 2
IS  - 4
SP  - 231
EP  - 236
PB  - David Publishing
CY  - Libertyville
ER  - 
TY  - JOUR
A1  - Vant, Christianne
A1  - Staat, Manfred
A1  - Baroud, Gamal
T1  - Percutaneous Vertebroplasty: A Review of Two Intraoperative Complications
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 527
EP  - 539
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Razavi, Arash
A1  - Besmehn, Astrid
A1  - Bijnens, Nathalie
A1  - Williams, Oliver A.
A1  - Haenen, Ken
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Penicillin detection with nanocrystalline-diamond field-effect sensor
JF  - physica status solidi (a). 205 (2008), H. 9
Y1  - 2008
SN  - 1862-6319
N1  - Special Issue: Hasselt Diamond Workshop 2008 - SBDD XIII
SP  - 2141
EP  - 2145
ER  - 
TY  - JOUR
A1  - Koch, Claudia
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Wege, Christian
T1  - Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors
JF  - Nanotheranostics
N2  - The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts.
Y1  - 2018
U6  - http://dx.doi.org/10.7150/ntno.22114
SN  - 2206-7418
VL  - 2
IS  - 2
SP  - 184
EP  - 196
PB  - Ivyspring
CY  - Sydney
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Thust, M.
A1  - Schroth, P.
A1  - Steffen, A.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of silicon-based field-effect structures
JF  - Sensors and Materials. 13 (2001), H. 4
Y1  - 2001
SN  - 0392-2510
SP  - 207
EP  - 223
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Simonis, A.
A1  - Ecken, H.
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?
JF  - Sensors and Actuators B. 78 (2001), H. 1-3
Y1  - 2001
SN  - 0925-4005
SP  - 237
EP  - 242
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, T.
A1  - Simonis, A.
A1  - Ecken, H.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?
JF  - Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]
Y1  - 2000
SN  - 87-89935-50-0
N1  - Eurosensors ; (14, 2000, København) ; Eurosensors ; (14 : ; 2000.08.27-30 : ; Copenhagen) ; European Conference on Solid-State Transducers ; (14 : ; 2000.08.27-30 : ; Copenhagen)
SP  - 27
EP  - 30
PB  - MIC, Mikroelektronik Centret
CY  - Lyngby, Denmark
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Penicillin biosensor based on a capacitive field-effect structure functionalized with a dendrimer/carbon nanotube multilayer
JF  - Biosensors and Bioelectronics. 25 (2009), H. 2
Y1  - 2009
SN  - 0956-5663
SP  - 497
EP  - 501
ER  - 
TY  - CHAP
A1  - Bhattarai, Aroj
A1  - Staat, Manfred
ED  - Fernandes, P.R.
ED  - Tavares, J. M.
T1  - Pectopexy to repair vaginal vault prolapse: a finite element approach
T2  - Proceedings CMBBE 2018
N2  - The vaginal prolapse after hysterectomy (removal of the uterus) is often associated with the prolapse of the vaginal vault, rectum, bladder, urethra or small bowel. Minimally
invasive surgery such as laparoscopic sacrocolpopexy and pectopexy are widely performed for the treatment of the vaginal prolapse with weakly supported vaginal vault after hysterectomy using prosthetic mesh implants to support (or strengthen) lax apical ligaments. Implants of different shape, size and polymers are selected depending on the patient’s anatomy and the surgeon’s preference. In this computational study on pectopexy, DynaMesh®-PRP soft, GYNECARE GYNEMESH® PS Nonabsorbable PROLENE® soft and Ultrapro® are tested in a 3D finite element model of the female pelvic floor. The mesh model is implanted into the extraperitoneal space and sutured to the vaginal stump with a bilateral fixation to the iliopectineal ligament at both sides. Numerical simulations are conducted at rest, after surgery and during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues and prosthetic meshes are modeled as incompressible, isotropic hyperelastic materials. The positions of the organs are calculated with respect to the pubococcygeal line (PCL) for female pelvic floor at rest, after repair and during Valsalva maneuver using the three meshes.
Y1  - 2018
N1  - 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 3rd Conference on Imaging and Visualization. CMBBE 2018. 26-29 March 2018, Lisbon, Portugal
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Mo, Xiumei
A1  - Ramakrishna, S.
T1  - PCL-PGLA composite tubular scaffold preparation and biocompatibility investigation / X. Mo, H.-J. Weber, S. Ramakrishna
JF  - The International journal of artificial organs. 29 (2006), H. 8
Y1  - 2006
SP  - 790
EP  - 799
PB  - -
ER  -