TY  - JOUR
A1  - Werfel, Stanislas
A1  - Günthner, Roman
A1  - Hapfelmeier, Alexander
A1  - Hanssen, Henner
A1  - Kotliar, Konstantin
A1  - Heemann, Uwe
A1  - Schmaderer, Christoph
ED  - Guzik, Tomasz J.
T1  - Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning
JF  - Cardiovascular Research
N2  - Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations.
KW  - Machine learning
KW  - Retinal vessels
KW  - Microcirculation
KW  - Haemodialysis
KW  - Myocardial infarction and cardiac death
Y1  - 2022
U6  - http://dx.doi.org/10.1093/cvr/cvab040
SN  - 0008-6363
VL  - 118
IS  - 2
SP  - 612
EP  - 621
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Angermann, Susanne
A1  - Günthner, Roman
A1  - Hanssen, Henner
A1  - Lorenz, Georg
A1  - Braunisch, Matthias C.
A1  - Steubl, Dominik
A1  - Matschkal, Julia
A1  - Kemmner, Stephan
A1  - Hausinger, Renate
A1  - Block, Zenonas
A1  - Haller, Bernhard
A1  - Heemann, Uwe
A1  - Kotliar, Konstantin
A1  - Grimmer, Timo
A1  - Schmaderer, Christoph
T1  - Cognitive impairment and microvascular function in end-stage renal disease
JF  - International Journal of Methods in Psychiatric Research (MPR)
N2  - Objective
Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels.

Methods
152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions.

Results
In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained.

Conclusion
This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.
KW  - cerebral small vessel disease
KW  - cognitive impairment
KW  - dialysis
KW  - retinal vessels
Y1  - 2022
U6  - http://dx.doi.org/10.1002/mpr.1909
SN  - 1049-8931 (Print)
SN  - 1557-0657 (Online)
VL  - 31
IS  - 2
SP  - 1
EP  - 10
PB  - Wiley
ER  -