TY  - GEN
A1  - Abdelghani, Adnane
A1  - Menaa, Bouzid
A1  - Obare, Sherine O.
A1  - Schöning, Michael Josef
T1  - Special issue on nanoscale science and technology / guest eds.: Adnane Abdelghani, Bouzid Menaa, Sherine O. Obare, Michael J. Schöning
T2  - International journal of nanotechnology
Y1  - 2013
SN  - 1741-8151 (E-Journal), 1475-7435 (Print)
VL  - Vol. 10
IS  - No. 5-7
SP  - 373
EP  - 619
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Ingebrandt, S.
A1  - Poghossian, Arshak
A1  - Zhang, Y.
A1  - Moritz, W.
A1  - Schöning, Michael Josef
T1  - Field-effect nanoplate capacitive pH sensor based on SOI structure
JF  - Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009
Y1  - 2009
SP  - 55
EP  - 58
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Ingebrandt, S.
A1  - Poghossian, Arshak
A1  - Zhang, Y.
A1  - Vu, X. T.
A1  - Moritz, W.
A1  - Schöning, Michael Josef
T1  - Nanoplate field-effect capacitive (bio-)chemical sensor array based on SOI structure
JF  - Procedia Chemistry. 1 (2009), H. 1
Y1  - 2009
SN  - 1876-6196
N1  - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23
SP  - 670
EP  - 673
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Pedraza, A. M.
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Label-free DNA hybridization and denaturation detection by means of field-effect nanoplate SOI capacitors functionalized with gold nanoparticles
JF  - Procedia Engineering. 5 (2010)
Y1  - 2010
SN  - 1877-7058
N1  - Proc. Eurosensors XXIV, September 5–8, 2010, Linz, Austria
SP  - 918
EP  - 921
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Cherstvy, Andrey G.
A1  - Pedraza, Angela M.
A1  - Ingebrandt, Sven
A1  - Schöning, Michael Josef
T1  - Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling
JF  - Physica Status Solidi (a)
N2  - Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.
Y1  - 2012
U6  - http://dx.doi.org/10.1002/pssa.201100710
SN  - 1862-6319
VL  - 209
SP  - 925
EP  - 934
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Pedraza, A. M.
A1  - Gandhi, D.
A1  - Ingebrandt, S.
A1  - Moritz, W.
A1  - Schöning, Michael Josef
T1  - An array of field-effect nanoplate SOI capacitors for (bio-)chemical sensing
JF  - Biosensors and Bioelectronics. 26 (2011), H. 6
Y1  - 2011
SN  - 0956-5663
SP  - 3023
EP  - 3028
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Razavi, A.
A1  - Williams, O. A.
A1  - Bijnens, N.
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Characterisation of capacitive field-effect sensors with a nanocrystalline-diamond film as transducer material for multi-parameter sensing
JF  - Biosensors and Bioelectronics. 24 (2009), H. 5
Y1  - 2009
SN  - 0956-5663
N1  - Selected Papers from the Tenth World Congress on Biosensors Shangai, China, May 14-16, 2008 ; Zeitschrift früher u.d.T. : Biosensors
SP  - 1298
EP  - 1304
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Razavi, Arash
A1  - Besmehn, Astrid
A1  - Bijnens, Nathalie
A1  - Williams, Oliver A.
A1  - Haenen, Ken
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Penicillin detection with nanocrystalline-diamond field-effect sensor
JF  - physica status solidi (a). 205 (2008), H. 9
Y1  - 2008
SN  - 1862-6319
N1  - Special Issue: Hasselt Diamond Workshop 2008 - SBDD XIII
SP  - 2141
EP  - 2145
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Siqueira, José R. Jr.
A1  - Oliveira, Osvaldo N. Jr.
A1  - Moritz, Werner
A1  - Schöning, Michael Josef
T1  - Capacitive electrolyte-insulator-semiconductor structures functionalised with a polyelectrolyte/enzyme multilayer: New strategy for enhanced field-effect biosensing
JF  - Physica Status Solidi (A). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 884
EP  - 890
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Christiaens, P.
A1  - Williams, O. A.
A1  - Wagner, P.
A1  - Haenen, K.
T1  - Feldeffektsensor auf nanokristalliner Diamantbasis
JF  - Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. März 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik
Y1  - 2008
SN  - 978-3-18-092011-5
N1  - VDI-Berichte ; 2011 ; Sensoren und Messsysteme 2008, 14. GMA/ITG-Fachtagung, VDI/VDE- Gesellschaft Mess- und Automatisierungstechnik, + CD-ROM, Ludwigsburg, DE, 11.-12. Mar, 2008
SP  - 549
EP  - 558
PB  - VDI-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Werner, Moritz
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Capacitance–voltage and impedance-spectroscopy characteristics of nanoplate EISOI capacitors
JF  - Physica status solidi (a) : applications and material science. 208 (2011), H. 6
Y1  - 2011
SN  - 1862-6319
SP  - 1327
EP  - 1332
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Arida, Hassan A.
A1  - Al-haddad, Ameera
A1  - Schöning, Michael Josef
T1  - New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode
JF  - International Journal of Electrochemical Science. 6 (2011), H. 9
Y1  - 2011
SN  - 1452-3981
SP  - 3858
EP  - 3867
ER  - 
TY  - CHAP
A1  - Arida, Hassan A.
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
T1  - Novel organic membrane-based thin-film microsensors for the determination of heavy metal cations
N2  - A first step towards the fabrication and electrochemical evaluation of thin-film microsensors based on organic PVC membranes for the determination of Hg(II), Cd(II), Pb(II) and Cu(II) ions in solutions has been realised. The membrane-coating mixture used in the preparation of this new type of microsensors is incorporating PVC as supporting matrix, o-nitrophenyloctylether (o-NPOE) as solvent mediator and a recently synthesized Hg[dimethylglyoxime(phene)]2+ and Bis-(4-hydroxyacetophenone)-ethylenediamine as electroactive materials for Hg(II) and Cd(II), respectively. A set of three commercialised ionophores for Cd(II), Pb(II) and Cu(II) has been also used for comparison. Thin-film microsensors based on these membranes showed a Nernstian response of slope (26-30 mV/dec.) for the respective tested cations. The potentiometric response characteristics (linear range, pH range, detection limit and response time) are comparable with those obtained by conventional membranes as well as coated wire electrodes prepared from the same membrane. The realisation of the new organic membrane-based thin-film microsensors overcomes the problem of an insufficient selectivity of solid-state-based thinfilm sensors.
KW  - Biosensor
KW  - Heavy metal detection
KW  - thin-film microsensors
KW  - organic PVC membranes
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1545
ER  - 
TY  - JOUR
A1  - Arida, Hassan
A1  - Mohsen, Q.
A1  - Schöning, Michael Josef
T1  - Microfabrication, characterization and analytical application of a new thin-film silver microsensor
JF  - Electrochimica Acta. 54 (2009), H. 13
Y1  - 2009
SN  - 0013-4686
SP  - 3543
EP  - 3547
ER  - 
TY  - JOUR
A1  - Arida, Hassan
A1  - Turek, Monika
A1  - Rolka, David
A1  - Schöning, Michael Josef
T1  - A Novel Thin-Film Copper Array Based on an Organic/Inorganic Sensor Hybrid: Microfabrication, Potentiometric Characterization, and Flow-Injection Analysis Application
JF  - Electroanalysis. 21 (2009), H. 10
Y1  - 2009
SN  - 1040-0397
SP  - 1145
EP  - 1151
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Effect of O2 plasma on properties of electrolyte-insulator-semiconductor structures
JF  - physica status solidi a : applications and materials sciences
N2  - Prior to immobilization of biomolecules or cells onto biosensor surfaces, the surface must be physically or chemically activated for further functionalization. Organosilanes are a versatile option as they facilitate the immobilization through their terminal groups and also display self-assembly. Incorporating hydroxyl groups is one of the important methods for primary immobilization. This can be done, for example, with oxygen plasma treatment. However, this treatment can affect the performance of the biosensors and this effect is not quite well understood for surface functionalization. In this work, the effect of O2 plasma treatment on EIS sensors was investigated by means of electrochemical characterizations: capacitance–voltage (C–V) and constant capacitance (ConCap) measurements. After O2 plasma treatment, the potential of the EIS sensor dramatically shifts to a more negative value. This was successfully reset by using an annealing process.
KW  - surface functionalization
KW  - O2 plasma
KW  - hydroxylation
KW  - electrolyte-insulator semiconductor sensor (EIS)
KW  - annealing
Y1  - 2017
U6  - http://dx.doi.org/10.1002/pssa.201700025
SN  - 1862-6319
VL  - 214
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Toward an immobilization method for spore-based biosensors in oxidative environment
JF  - Electrochimica Acta
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.electacta.2019.01.148
VL  - 302
SP  - 394
EP  - 401
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Combined calorimetric gas- and spore-based biosensor array for online monitoring and sterility assurance of gaseous hydrogen peroxide in aseptic filling machines
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.111628
SN  - 0956-5663
VL  - 143
IS  - 111628
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Mätzkow, Malte
A1  - Durán, Marlena Palomar
A1  - Greeff, Anton
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Optimization of the immobilization of bacterial spores on glass substrates with organosilanes
JF  - Physica status solidi (A) : Applications and materials science
N2  - Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication.
KW  - silanization
KW  - organosilanes
KW  - immobilization
KW  - endospores
KW  - biosensors
KW  - Bacillus atrophaeus
Y1  - 2016
U6  - http://dx.doi.org/10.1002/pssa.201532914
SN  - 1862-6319
VL  - 213
IS  - 6
SP  - 1463
EP  - 1470
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Oberländer, Jan
A1  - Mätzkow, M.
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Surface functionalization for spore-based biosensors with organosilanes
JF  - Electrochimica Acta
N2  - In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated.
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.electacta.2017.04.157
SN  - 0013-4686
VL  - 241
SP  - 237
EP  - 243
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bandodkar, Amay J.
A1  - Molinnus, Denise
A1  - Mirza, Omar
A1  - Guinovart, Tomas
A1  - Windmiller, Joshua R.
A1  - Valdes-Ramirez, Gabriela
A1  - Andrade, Francisco J.
A1  - Schöning, Michael Josef
A1  - Wang, Joseph
T1  - Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring
JF  - Biosensors and bioelectronics
N2  - This article describes the fabrication, characterization and application of an epidermal temporary-transfer tattoo-based potentiometric sensor, coupled with a miniaturized wearable wireless transceiver, for real-time monitoring of sodium in the human perspiration. Sodium excreted during perspiration is an excellent marker for electrolyte imbalance and provides valuable information regarding an individual's physical and mental wellbeing. The realization of the new skin-worn non-invasive tattoo-like sensing device has been realized by amalgamating several state-of-the-art thick film, laser printing, solid-state potentiometry, fluidics and wireless technologies. The resulting tattoo-based potentiometric sodium sensor displays a rapid near-Nernstian response with negligible carryover effects, and good resiliency against various mechanical deformations experienced by the human epidermis. On-body testing of the tattoo sensor coupled to a wireless transceiver during exercise activity demonstrated its ability to continuously monitor sweat sodium dynamics. The real-time sweat sodium concentration was transmitted wirelessly via a body-worn transceiver from the sodium tattoo sensor to a notebook while the subjects perspired on a stationary cycle. The favorable analytical performance along with the wearable nature of the wireless transceiver makes the new epidermal potentiometric sensing system attractive for continuous monitoring the sodium dynamics in human perspiration during diverse activities relevant to the healthcare, fitness, military, healthcare and skin-care domains.
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.bios.2013.11.039
SN  - 1873-4235 (E-Journal); 0956-5663 (Print)
VL  - 54
SP  - 603
EP  - 609
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Beging, Stefan
A1  - Leinhos, Marcel
A1  - Jablonski, Melanie
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Studying the spatially resolved immobilisation of enzymes on a capacitive field-effect structure by means of nano-spotting
JF  - Physica status solidi (a)
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431891
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1353
EP  - 1358
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Beging, Stefan
A1  - Mlynek, Daniela
A1  - Hataihimakul, Sudkanung
A1  - Poghossian, Arshak
A1  - Baldsiefen, Gerhard
A1  - Busch, Heinz
A1  - Laube, Norbert
A1  - Kleinen, Lisa
A1  - Schöning, Michael Josef
T1  - Field-effect calcium sensor for the determination of the risk of urinary stone  formation
JF  - Sensors and Actuators B: Chemical. 144 (2010), H. 2
Y1  - 2010
N1  - 22nd International Conference on Eurosensors - Dresden, Germany, 7-10 September 2008 ; Eurosensors ; (22, 2008, Dresden)
SP  - 374
EP  - 379
ER  - 
TY  - CHAP
A1  - Beging, Stefan
A1  - Poghossian, Arshak
A1  - Mlynek, D.
A1  - Hataihimakul, S.
A1  - Pedraza, A.
A1  - Dhawan, S.
A1  - Laube, N.
A1  - Kleinen, L.
A1  - Baldsiefen, G.
A1  - Busch, H.
A1  - Schöning, Michael Josef
T1  - Ion-selective sensors for the determination of the risk of urinary stone formation
T2  - Micro- and Nanosystems in biochemical diagnosis : Principles and applications
Y1  - 2010
SP  - 74
EP  - 80
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Beging, Stefan
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Hataihimakul, Sudkanung
A1  - Busch, H.
A1  - Baldsiefen, G.
A1  - Laube, N.
A1  - Kleinen, L.
A1  - Hosseiny, R.
T1  - Feldeffektbasierender Ca2+-sensitiver Sensor für den Einsatz im Nativurin zur Bestimmung des Harnsteinbildungsrisikos
JF  - Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. März 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik
Y1  - 2008
SN  - 978-3-18-092011-5
N1  - VDI-Berichte ; 2011 ; Sensoren und Messsysteme 2008, 14. GMA/ITG-Fachtagung, VDI/VDE- Gesellschaft Mess- und Automatisierungstechnik, + CD-ROM, Ludwigsburg, DE, 11.-12. Mar, 2008
SP  - 775
EP  - 782
PB  - VDI-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Bertz, Morten
A1  - Molinnus, Denise
A1  - Schöning, Michael Josef
A1  - Homma, Takayuki
T1  - Real-time monitoring of H₂O₂ sterilization on individual bacillus atrophaeus spores by optical sensing with trapping Raman spectroscopy
JF  - Chemosensors
N2  - Hydrogen peroxide (H₂O₂), a strong oxidizer, is a commonly used sterilization agent employed during aseptic food processing and medical applications. To assess the sterilization efficiency with H₂O₂, bacterial spores are common microbial systems due to their remarkable robustness against a wide variety of decontamination strategies. Despite their widespread use, there is, however, only little information about the detailed time-resolved mechanism underlying the oxidative spore death by H₂O₂. In this work, we investigate chemical and morphological changes of individual Bacillus atrophaeus spores undergoing oxidative damage using optical sensing with trapping Raman microscopy in real-time. The time-resolved experiments reveal that spore death involves two distinct phases: (i) an initial phase dominated by the fast release of dipicolinic acid (DPA), a major spore biomarker, which indicates the rupture of the spore’s core; and (ii) the oxidation of the remaining spore material resulting in the subsequent fragmentation of the spores’ coat. Simultaneous observation of the spore morphology by optical microscopy corroborates these mechanisms. The dependence of the onset of DPA release and the time constant of spore fragmentation on H₂O₂ shows that the formation of reactive oxygen species from H₂O₂ is the rate-limiting factor of oxidative spore death.
KW  - DPA (dipicolinic acid)
KW  - sterilization
KW  - Bacillus atrophaeus spores
KW  - optical trapping
KW  - Raman spectroscopy
KW  - optical sensor setup
Y1  - 2023
U6  - http://dx.doi.org/10.3390/chemosensors11080445
SN  - 2227-9040
N1  - This article belongs to the Special Issue "Biosensors and Chemical Sensors for Food and Healthcare Monitoring—Celebrating the 10th Anniversary"
VL  - 8
IS  - 11
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Bertz, Morten
A1  - Schöning, Michael Josef
A1  - Molinnus, Denise
A1  - Homma, Takayuki
T1  - Influence of temperature, light, and H₂O₂ concentration on microbial spore inactivation: in-situ Raman spectroscopy combined with optical trapping
JF  - Physica status solidi (a) applications and materials science
N2  - To gain insight on chemical sterilization processes, the influence of temperature (up to 70 °C), intense green light, and hydrogen peroxide (H₂O₂) concentration (up to 30% in aqueous solution) on microbial spore inactivation is evaluated by in-situ Raman spectroscopy with an optical trap. Bacillus atrophaeus is utilized as a model organism. Individual spores are isolated and their chemical makeup is monitored under dynamically changing conditions (temperature, light, and H₂O₂ concentration) to mimic industrially relevant process parameters for sterilization in the field of aseptic food processing. While isolated spores in water are highly stable, even at elevated temperatures of 70 °C, exposure to H₂O₂ leads to a loss of spore integrity characterized by the release of the key spore biomarker dipicolinic acid (DPA) in a concentration-dependent manner, which indicates damage to the inner membrane of the spore. Intensive light or heat, both of which accelerate the decomposition of H₂O₂ into reactive oxygen species (ROS), drastically shorten the spore lifetime, suggesting the formation of ROS as a rate-limiting step during sterilization. It is concluded that Raman spectroscopy can deliver mechanistic insight into the mode of action of H₂O₂-based sterilization and reveal the individual contributions of different sterilization methods acting in tandem.
KW  - hydrogen peroxide
KW  - optical spore trapping
KW  - Raman spectroscopy
KW  - sterilization conditions
KW  - temperature
Y1  - 2024
U6  - http://dx.doi.org/10.1002/pssa.202300866
SN  - 1862-6319 (Online)
SN  - 1862-6300 (Print)
IS  - Early View
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Schnitzler, Thomas
A1  - Zang, Werner
A1  - Wagner, P.
T1  - Entwicklung eines modularen festkörperbasierten Sensorsystems für die Überwachung von Zellkulturfermenationen
JF  - Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA)
Y1  - 2010
SN  - 978-3-8007-3260-9
N1  - Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik
SP  - 688
EP  - 691
PB  - VDE Verlag
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Bohrn, U.
A1  - Stütz, E.
A1  - Fleischer, M.
A1  - Schöning, Michael Josef
T1  - Real-time detection of CO by eukaryotic cells
JF  - Procedia Engineering. 5 (2010)
Y1  - 2010
SN  - 1877-7058
N1  - Eurosensor XXIV Conference
SP  - 17
EP  - 20
ER  - 
TY  - CHAP
A1  - Bohrn, Ulrich
A1  - Mucha, Andreas
A1  - Werner, Frederik
A1  - Stütz, Evamaria
A1  - Bäcker, Matthias
A1  - Krumbe, Christoph
A1  - Schienle, Meinrad
A1  - Fleischer, Maximilian
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Detection of toxic chromium species in water using cellbased sensor systems
Y1  - 2012
SN  - 978-3-9813484-2-2
U6  - http://dx.doi.org/10.5162/IMCS2012/P2.1.14
SP  - 1364
EP  - 1367
ER  - 
TY  - JOUR
A1  - Bohrn, Ulrich
A1  - Mucha, Andreas
A1  - Werner, Frederik
A1  - Trattner, Barbara
A1  - Bäcker, Matthias
A1  - Krumbe, Christoph
A1  - Schienle, Meinrad
A1  - Stütz, Evamaria
A1  - Schmitt-Landsiedel, Doris
A1  - Fleischer, Maximilian
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - A critical comparison of cell-based sensor systems for the detection of Cr (VI) in aquatic environment
JF  - Sensors and actuators. B: Chemical
Y1  - 2013
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
VL  - Vol. 182
SP  - 58
EP  - 65
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bohrn, Ulrich
A1  - Stütz, Evamaria
A1  - Fleischer, Maximilian
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
T1  - Eukaryotic cell lines as a sensitive layer for direct monitoring of carbon monoxide
JF  - Physica status solidi (a) : applications and material science. 208 (2011), H. 6
Y1  - 2011
SN  - 1862-6319
SP  - 1345
EP  - 1350
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bohrn, Ulrich
A1  - Stütz, Evamaria
A1  - Fleischer, Maximilian
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
T1  - Using a cell-based gas biosensor for investigation of adverse effects of acetone vapors in vitro
JF  - Biosensors and Bioelectronics. 40 (2013), H. 1
Y1  - 2013
SN  - 0956-5663
SP  - 393
EP  - 400
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Bohrn, Ulrich
A1  - Stütz, Evamaria
A1  - Fleischer, Maximilian
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
T1  - Living cell-based gas sensor system for the detection of acetone in air
Y1  - 2012
SN  - 978-3-9813484-2-2
U6  - http://dx.doi.org/10.5162/IMCS2012/3.2.3
SP  - 269
EP  - 272
ER  - 
TY  - JOUR
A1  - Bressel, A.
A1  - Schultze, J.W.
A1  - Khan, W.
A1  - Wolfaardt, G. M.
A1  - Rohns, H.-P.
A1  - Irmscher, R.
A1  - Schöning, Michael Josef
T1  - High resolution gravimetric, optical and electrochemical investigations of microbial biofilm formation in aqueous systems
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SN  - 0013-4686
SP  - 3363
EP  - 3372
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Investigation of the spatial resolution of a laser-based stimulation process for light-addressable hydrogels with incorporated graphene oxide by means of IR thermography
JF  - Sensors and Actuators A: Physical
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.sna.2017.11.031
SN  - 0924-4247
VL  - 268
SP  - 126
EP  - 132
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Pilas, Johanna
A1  - Guthmann, Eric
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Towards light-addressable flow control: responsive hydrogels with incorporated graphene oxide as laser-driven actuator structures within microfluidic channels
JF  - Sensor and Actuators B: Chemical
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.snb.2019.02.086
SN  - 0925-4005
VL  - 288
SP  - 579
EP  - 585
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Raue, Markus
A1  - Kirschbaum, M.
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, R.
A1  - Wagner, Torsten
T1  - Light-controllable polymeric material based on temperature-sensitive hydrogels with incorporated graphene oxide
JF  - Physica status solidi (a)
N2  - Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel films with incorporated graphene oxide (GO) were developed and tested as light-stimulated actuators. GO dispersions were synthesized via Hummers method and characterized toward their optical properties and photothermal energy conversion. The hydrogels were prepared by means of photopolymerization. In addition, the influence of GO within the hydrogel network on the lower critical solution temperature (LCST) was investigated by differential scanning calorimetry (DSC). The optical absorbance and the response to illumination were determined as a function of GO concentration for thin hydrogel films. A proof of principle for the stimulation with light was performed.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431944
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1368
EP  - 1374
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Breuer, Lars
A1  - Raue, Markus
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Light-stimulated hydrogel actuators with incorporated graphene oxide for microfluidic applications
T2  - 12. Dresdner Sensor-Symposium 2015
Y1  - 2015
U6  - http://dx.doi.org/10.5162/12dss2015/P5.8
SP  - 206
EP  - 209
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Raue, Markus
A1  - Strobel, M.
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, R.
A1  - Wagner, Torsten
T1  - Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems
JF  - Physica status solidi (a)
N2  - Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium.
Y1  - 2016
U6  - http://dx.doi.org/10.1002/pssa.201533056
SN  - 1862-6300
VL  - 213
IS  - 6
SP  - 1520
EP  - 1525
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Jessing, Max P.
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors
JF  - Analytical Chemistry
N2  - Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.
Y1  - 2018
U6  - http://dx.doi.org/10.1021/acs.analchem.8b01807
SN  - 0003-2700
VL  - 90
IS  - 12
SP  - 7747
EP  - 7753
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Jessing, Max P.
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Surface regeneration and reusability of label-free DNA biosensors based on weak polyelectrolyte-modified capacitive field-effect structures
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2018.11.019
SN  - 0956-5663
VL  - 126
SP  - 510
EP  - 517
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Label-free detection of double-stranded DNA molecules with polyelectrolyte-modified capacitive field-effect sensors
T1  - Markierungsfreie Detektion doppelsträngiger DNA Moleküle mit Hilfe von Polyelektrolyt-modifizierten kapazitiven Feldeffekt-Sensoren
JF  - tm - Technisches Messen
N2  - In this study, polyelectrolyte-modified field-effect-based electrolyte-insulator-semiconductor (EIS) devices have been used for the label-free electrical detection of double-stranded deoxyribonucleic acid (dsDNA)molecules. The sensor-chip functionalization with a positively charged polyelectrolyte layer provides the possibility of direct adsorptive binding of negatively charged target DNA oligonucleotides onto theSiO2-chip surface.EIS sensors can be utilized as a tool to detect surface-charge changes; the electrostatic adsorption of oligonucleotides onto the polyelectrolyte layer leads to a measureable surface-potential change. Signals of 39mV have been recorded after the incubation with the oligonucleotide solution. Besides the electrochemical experiments, the successful adsorption of dsDNA onto the polyelectrolyte layer has been verified via fluorescence microscopy. The presented results demonstrate that the signal recording of EISchips, which are modified with a polyelectrolyte layer, canbe used as a favorable approach for a fast, cheap and simple detection method for dsDNA.
Y1  - 2017
U6  - http://dx.doi.org/10.1515/teme-2017-0015
VL  - 84
IS  - 10
SP  - 628
EP  - 634
PB  - De Gruyter
CY  - Oldenbourg
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Scheja, S.
A1  - Wu, Chunsheng
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Electrostatic Detection of Unlabelled Single- and Double-stranded DNA Using Capacitive Field-effect Devices Functionalized with a Positively Charged Polyelectrolyte Layer
JF  - Procedia Engineering
N2  - Capacitive field-effect electrolyte-insulator-semiconductor sensors consisting of an Al-p-Si-SiO2 structure have been used for the electrical detection of unlabelled single- and double-stranded DNA (dsDNA) molecules by their intrinsic charge. A simple functionalization protocol based on the layer-by-layer (LbL) technique was used to prepare a weak polyelectrolyte/probe-DNA bilayer, followed by the hybridization with complementary target DNA molecules. Due to the flat orientation of the LbL-adsorbed DNA molecules, a high sensor signal has been achieved. In addition, direct label-free detection of in-solution hybridized dsDNA molecules has been studied.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.710
SN  - 1877-7058
N1  - Eurosensors 2015
VL  - 120
SP  - 544
EP  - 547
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Scheja, Sabrina
A1  - Wu, Chunsheng
A1  - Keusgen, Michael
A1  - Mewes, Dieter
A1  - Schöning, Michael Josef
T1  - DNA Immobilization and Hybridization Detection by the Intrinsic Molecular Charge Using Capacitive Field-Effect Sensors Modified with a Charged Weak Polyelectrolyte Layer
JF  - Applied Materials & Interfaces
N2  - Miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge favor the semiconductor field-effect platform as one of the most attractive approaches for the development of label-free DNA chips. In this work, a capacitive field-effect EIS (electrolyte–insulator–semiconductor) sensor covered with a layer-by-layer prepared, positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was used for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization. The negatively charged probe single-stranded DNA (ssDNA) molecules were electrostatically adsorbed onto the positively charged PAH layer, resulting in a preferentially flat orientation of the ssDNA molecules within the Debye length, thus yielding a reduced charge-screening effect and a higher sensor signal. Each sensor-surface modification step (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), reducing an unspecific adsorption by a blocking agent, incubation with noncomplementary DNA (ncDNA) solution) was monitored by means of capacitance–voltage and constant-capacitance measurements. In addition, the surface morphology of the PAH layer was studied by atomic force microscopy and contact-angle measurements. High hybridization signals of 34 and 43 mV were recorded in low-ionic strength solutions of 10 and 1 mM, respectively. In contrast, a small signal of 4 mV was recorded in the case of unspecific adsorption of fully mismatched ncDNA. The density of probe ssDNA and dsDNA molecules as well as the hybridization efficiency was estimated using the experimentally measured DNA immobilization and hybridization signals and a simplified double-layer capacitor model. The results of field-effect experiments were supported by fluorescence measurements, verifying the DNA-immobilization and hybridization event.
Y1  - 2015
U6  - http://dx.doi.org/10.1021/acsami.5b05146
VL  - 36
IS  - 7
SP  - 20068
EP  - 20075
PB  - American Chemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Buniatyan, V.
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Aroutiounian, V. M.
A1  - Schöning, Michael Josef
T1  - BaxSr1-x TiO3/pc-Si heterojunction capacitance
JF  - Armenian journal of physics
Y1  - 2013
SN  - 1829-1171
VL  - 6
IS  - 4
SP  - 188
EP  - 197
PB  - National Academy of Sciences of Armenia
CY  - Yerevan
ER  - 
TY  - JOUR
A1  - Buniatyan, V.
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Aroutiounian, V. M.
A1  - Schöning, Michael Josef
T1  - BaxSr1-x TiO3/pc-Si heterojunction
JF  - Armenian journal of physics
Y1  - 2013
SN  - 1829-1171
VL  - 6
IS  - 4
SP  - 177
EP  - 187
PB  - National Academy of Sciences of Armenia
CY  - Yerevan
ER  - 
TY  - CHAP
A1  - Buniatyan, V. V.
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Rustamyan, L. G.
A1  - Hovnikyan, H. H.
T1  - Equivalent circuit and optimization of impedance characteristics of an electrolyte conductivity sensor
T2  - Proceedings of State Engineering University Armenia : Series Information technologies, electronics, radio engineering
Y1  - 2014
VL  - Iss. 17
IS  - No. 1
SP  - 69
EP  - 76
ER  - 
TY  - JOUR
A1  - Buniatyan, V. V.
A1  - Matirosyan, N. W.
A1  - Abouzar, Maryam H.
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Schubert, J.
A1  - Khachatryan, V. R.
A1  - Soukiassyan, G. R.
T1  - (Ba,Sr)TiO3 based electrolyte-insulator-semiconductor pHsensors: comparitive study
JF  - Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009
Y1  - 2009
SP  - 71
EP  - 74
ER  - 
TY  - JOUR
A1  - Buniatyan, Vahe V.
A1  - Abouzar, Maryam H.
A1  - Martirosyan, Norayr W.
A1  - Schubert, Jürgen
A1  - Gevorgian, Spartak
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - pH-sensitive properties of barium strontium titanate (BST) thin films prepared by pulsed laser deposition technique
JF  - Physica Status Solidi (A). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 824
EP  - 830
ER  - 
TY  - JOUR
A1  - Buniatyan, Vahe V.
A1  - Matirosyan, N.
A1  - Abouzar, Maryam H.
A1  - Schubert, J.
A1  - Zander, W.
A1  - Gevorgian, S.
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Capacitive field-effect pH sensor based on an electrolyte-ferroelectric-insulator-semiconductor structure
JF  - SENSOR 2009 : : 14th International Conference on Sensors, Technologies, Electronics and Applications; Nürnberg, Germany, 26 - 28 May 2009; proceedings; [part of] Sensor + Test Conference 2009 / AMA, Fachverband für Sensorik e.V
Y1  - 2009
SN  - 9783981099355
N1  - AMA, Fachverband für Sensorik ; Sensor International Conference ; (14 : ; 2009.05.26-28 : ; Nürnberg)
SP  - 317
EP  - 322
PB  - AMA Service
CY  - Wunstorf
ER  - 
TY  - JOUR
A1  - Bäcker, M.
A1  - Rakowski, D.
A1  - Krappen, E.
A1  - Schöning, Michael Josef
T1  - Reinigungsprozesse in der Lebensmittelindustrie. Entwicklung eines Demonstrators zur Überwachung
JF  - GIT Labor-Fachzeitschrift
Y1  - 2017
SN  - 0016-3538
VL  - 61
IS  - 8
SP  - 26
EP  - 28
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Beging, Stefan
A1  - Biselli, Manfred
A1  - Poghossian, Arshak
A1  - Wang, J.
A1  - Zang, Werner
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Concept for a solid-state multi-parameter sensor system for cell-culture monitoring
JF  - Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI
Y1  - 2009
SN  - 0013-4686
SP  - 6107
EP  - 6112
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Delle, L.
A1  - Poghossian, Arshak
A1  - Biselli, Manfred
A1  - Zang, Werner
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Electrochemical sensor array for bioprocess monitoring
JF  - Electrochimica Acta (2011)
Y1  - 2011
VL  - 56
IS  - 26
SP  - 9673
EP  - 9678
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Bäcker, Matthias
A1  - Koch, C.
A1  - Geiger, F.
A1  - Eber, F.
A1  - Gliemann, H.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - A New Class of Biosensors Based on Tobacco Mosaic Virus and Coat Proteins as Enzyme Nanocarrier
T2  - Procedia Engineering
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.proeng.2016.11.228
SN  - 1877-7058
N1  - Proceedings of the 30th anniversary Eurosensors Conference – Eurosensors 2016, 4-7. Sepember 2016, Budapest, Hungary
VL  - Vol. 168
SP  - 618
EP  - 621
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Koch, Claudia
A1  - Eiben, Sabine
A1  - Geiger, Fania
A1  - Eber, Fabian
A1  - Gliemann, Hartmut
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors
JF  - Sensors and Actuators B: Chemical
N2  - The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips.
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.snb.2016.07.096
SN  - 0925-4005
VL  - 238
SP  - 716
EP  - 722
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Kowollik, Silvia
A1  - Schnitzler, Thomas
A1  - Wang, J.
A1  - Poghossian, Arshak
A1  - Zang, Werner
A1  - Biselli, Manfred
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Entwicklung eines festkörperbasierten Sensorsystems für die Bioprozessautomatisierung
JF  - 9. Dresdner Sensor-Symposium : Dresden, 07.-09. Dezember 2009 / Gerlach, Gerald ; Hauptmann, Peter [Hrsg.]
Y1  - 2009
SN  - 978-3-941298-44-6
N1  - Dresdner Sensor-Symposium ; (9, 2009, Dresden)
SP  - 197
EP  - 200
PB  - TUDpress
CY  - Dresden
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Kramer, F.
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bratov, A.
A1  - Abramova, N.
A1  - Schöning, Michael Josef
T1  - Planar and 3D interdigitated electrodes for biosensing applications: The impact of a dielectric barrier on the sensor properties
JF  - Physica Status Solidi (A) - Applications and Materials Science
N2  - Planar and three-dimensional (3D) interdigitated electrodes (IDE) with electrode digits separated by an insulating barrier of different heights were electrochemically characterized and compared in terms of their sensing properties. Due to the impact of the surface resistance, both types of IDE structures display a non-linear behavior in low-ionic strength solutions. The experimental data were fitted to an electrical equivalent circuit and interpreted taking into account the surface-charge-governed properties. The effect of a charged polyelectrolyte layer electrostatically assembled onto the sensor surface on the surface resistance in solutions with different KCl concentration is studied. In case of the same electrode footprint, 3D-IDEs show a larger cell constant and a higher sensitivity to molecular adsorption than that of planar IDEs. The obtained results demonstrate the potential of 3D-IDEs as a new transducer structure for a direct label-free sensing of charged molecules.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/pssa.201330416
SN  - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1357
EP  - 1363
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Wenmackers, Sylvia
A1  - Janssens, Stoffel D.
A1  - Haenen, Ken
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Capacitive field-effect (bio-)chemical sensors based on nanocrystalline diamond films
JF  - Diamond Electronics and Bioelectronics — Fundamentals to Applications III, edited by P. Bergonzo, [u.a.]
Y1  - 2010
N1  - MRS Proceedings Volume 1203 paper 1203-J17-31 ; Mater. Res. Soc. Sympos. Proc. Vol 1203 (2010) ; Materials Research Society
SP  - 1
EP  - 6
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Pouyeshman, S.
A1  - Schnitzler, Thomas
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Biselli, Manfred
A1  - Schöning, Michael Josef
T1  - A silicon-based multi-sensor chip for monitoring of fermentation processes
JF  - Physica status solidi (a) : applications and material science. 208 (2011), H. 6
Y1  - 2011
SN  - 1862-6319
SP  - 1364
EP  - 1369
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Rakowski, D.
A1  - Poghossian, Arshak
A1  - Biselli, Manfred
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis
JF  - Journal of Biotechnology
N2  - A microfluidic chip integrating amperometric enzyme sensors for the detection of glucose, glutamate and glutamine in cell-culture fermentation processes has been developed. The enzymes glucose oxidase, glutamate oxidase and glutaminase were immobilized by means of cross-linking with glutaraldehyde on platinum thin-film electrodes integrated within a microfluidic channel. The biosensor chip was coupled to a flow-injection analysis system for electrochemical characterization of the sensors. The sensors have been characterized in terms of sensitivity, linear working range and detection limit. The sensitivity evaluated from the respective peak areas was 1.47, 3.68 and 0.28 μAs/mM for the glucose, glutamate and glutamine sensor, respectively. The calibration curves were linear up to a concentration of 20 mM glucose and glutamine and up to 10 mM for glutamate. The lower detection limit amounted to be 0.05 mM for the glucose and glutamate sensor, respectively, and 0.1 mM for the glutamine sensor. Experiments in cell-culture medium have demonstrated a good correlation between the glutamate, glutamine and glucose concentrations measured with the chip-based biosensors in a differential-mode and the commercially available instrumentation. The obtained results demonstrate the feasibility of the realized microfluidic biosensor chip for monitoring of bioprocesses.
Y1  - 2013
U6  - http://dx.doi.org/10.1016/j.jbiotec.2012.03.014
SN  - 0168-1656
VL  - 163
IS  - 4
SP  - 371
EP  - 376
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Raue, Markus
A1  - Schusser, Sebastian
A1  - Jeitner, C.
A1  - Breuer, L.
A1  - Wagner, P.
A1  - Poghossian, Arshak
A1  - Förster, Arnold
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
T1  - Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films
JF  - Physica Status Solidi  (a)
N2  - Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3–12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.
Y1  - 2012
U6  - http://dx.doi.org/10.1002/pssa.201100763
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 839
EP  - 845
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Bäcker, Matthias
A1  - Schusser, Sebastian
A1  - Leinhos, Marcel
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Sensor system for the monitoring of degradation processes of biodegradable biopolymers
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 4
PB  - VDE-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Schusser, Sebastian
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Degradationsverhalten bioabbaubarer Polymere : siliziumbasierte Sensorik zur Überwachung
JF  - GIT Labor-Fachzeitschrift
Y1  - 2013
SN  - 0016-3538
SP  - 32
EP  - 33
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Schusser, Sebastian
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Multi-Parametererfassung mit siliziumbasiertem Sensorchip: Aus Drei mach Eins
JF  - GIT Labor-Fachzeitschrift
Y1  - 2014
SN  - 0016-3538
IS  - 2
SP  - 28
EP  - 30
PB  - Wiley
ER  - 
TY  - JOUR
A1  - Christiaens, P.
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Wagner, Torsten
A1  - Bijnens, N.
A1  - Williams, O. A.
A1  - Daenen, M.
A1  - Haenen, K.
A1  - Douthéret, O.
A1  - Haen, J. d´
A1  - Mekhalif, Z.
A1  - Schöning, Michael Josef
A1  - Wagner, P.
T1  - pH sensitivity of nanocrystalline diamond films
JF  - Physica status solidi (A). 204 (2007), H. 9
Y1  - 2007
SN  - 0031-8965
SP  - 2925
EP  - 2930
ER  - 
TY  - JOUR
A1  - Christiaens, P.
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Wagner, Torsten
A1  - Bijnens, N.
A1  - Williams, O. A.
A1  - Daenen, M.
A1  - Haenen, K.
A1  - Schöning, Michael Josef
A1  - Wagner, P.
T1  - Nanocrystalline diamond-based field-effect capacitive pH sensor
JF  - Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)
Y1  - 2007
SN  - 1-4244-0841-5
N1  - Eurosensors 21, 2007, Lyon ; International Conference on Solid-State Sensors, Actuators and Microsystems 14, 2007, Lyon
SP  - 1891
EP  - 1894
PB  - IEEE
CY  - Piscataway
ER  - 
TY  - JOUR
A1  - Cornelis, Peter
A1  - Givanoudi, Stella
A1  - Yongabi, Derick
A1  - Iken, Heiko
A1  - Duwé, Sam
A1  - Deschaume, Olivier
A1  - Robbens, Johan
A1  - Dedecker, Peter
A1  - Bartic, Carmen
A1  - Wübbenhorst, Michael
A1  - Schöning, Michael Josef
A1  - Heyndrickx, Marc
A1  - Wagner, Patrick
T1  - Sensitive and specific detection of E. coli using biomimetic receptors in combination with a modified heat-transfer method
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.04.026
SN  - 0956-5663
VL  - 136
SP  - 97
EP  - 105
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dantism, S.
A1  - Takenaga, S.
A1  - Wagner, P.
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Light-addressable Potentiometric Sensor (LAPS) Combined with Multi-chamber Structures to Investigate the Metabolic Activity of Cells
JF  - Procedia Engineering
N2  - LAPS are field-effect-based potentiometric sensors which are able to monitor analyte concentrations in a spatially resolved manner. Hence, a LAPS sensor system is a powerful device to record chemical imaging of the concentration of chemical species in an aqueous solution, chemical reactions, or the growth of cell colonies on the sensor surface, to record chemical images. In this work, multi-chamber 3D-printed structures made out of polymer (PP-ABS) were combined with LAPS chips to analyse differentially and simultaneously the metabolic activity of Escherichia coli K12 and Chinese hamster ovary (CHO) cells, and the responds of those cells to the addition of glucose solution.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.647
SN  - 1877-7058
N1  - Part of special issue "Eurosensors 2015"
VL  - 120
SP  - 384
EP  - 387
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Dahmen, Markus
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - LAPS-based monitoring of metabolic responses of bacterial cultures in a paper fermentation broth
JF  - Sensors and Actuators B: Chemical
N2  - As an alternative renewable energy source, methane production in biogas plants is gaining more and more attention. Biomass in a bioreactor contains different types of microorganisms, which should be considered in terms of process-stability control. Metabolically inactive microorganisms within the fermentation process can lead to undesirable, time-consuming and cost-intensive interventions. Hence, monitoring of the cellular metabolism of bacterial populations in a fermentation broth is crucial to improve the biogas production, operation efficiency, and sustainability. In this work, the extracellular acidification of bacteria in a paper-fermentation broth is monitored after glucose uptake, utilizing a differential light-addressable potentiometric sensor (LAPS) system. The LAPS system is loaded with three different model microorganisms (Escherichia coli, Corynebacterium glutamicum, and Lactobacillus brevis) and the effect of the fermentation broth at different process stages on the metabolism of these bacteria is studied. In this way, different signal patterns related to the metabolic response of microorganisms can be identified. By means of calibration curves after glucose uptake, the overall extracellular acidification of bacterial populations within the fermentation process can be evaluated.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.snb.2020.128232
SN  - 0925-4005
VL  - 320
IS  - Art. 128232
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Selmer, Thorsten
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.111332
VL  - 139
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Wagner, Torsten
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - A LAPS-based differential sensor for parallelized metabolism monitoring of various bacteria
JF  - Sensors
N2  - Monitoring the cellular metabolism of bacteria in (bio)fermentation processes is crucial to control and steer them, and to prevent undesired disturbances linked to metabolically inactive microorganisms. In this context, cell-based biosensors can play an important role to improve the quality and increase the yield of such processes. This work describes the simultaneous analysis of the metabolic behavior of three different types of bacteria by means of a differential light-addressable potentiometric sensor (LAPS) set-up. The study includes Lactobacillus brevis, Corynebacterium glutamicum, and Escherichia coli, which are often applied in fermentation processes in bioreactors. Differential measurements were carried out to compensate undesirable influences such as sensor signal drift, and pH value variation during the measurements. Furthermore, calibration curves of the cellular metabolism were established as a function of the glucose concentration or cell number variation with all three model microorganisms. In this context, simultaneous (bio)sensing with the multi-organism LAPS-based set-up can open new possibilities for a cost-effective, rapid detection of the extracellular acidification of bacteria on a single sensor chip. It can be applied to evaluate the metabolic response of bacteria populations in a (bio)fermentation process, for instance, in the biogas fermentation process.
Y1  - 2019
U6  - http://dx.doi.org/10.3390/s19214692
SN  - 1424-8220
VL  - 19
IS  - 21
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Optimization of Cell-Based Multi-Chamber LAPS Measurements Utilizing FPGA-Controlled Laser-Diode Modules
JF  - physica status solidi a : applications and materials sciences
N2  - A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric device, which detects concentration changes of an analyte solution on the sensor surface in a spatially resolved way. It uses a light source to generate electron–hole pairs inside the semiconductor, which are separated in the depletion region due to an applied bias voltage across the sensor structure and hence, a surface-potential-dependent photocurrent can be read out. However, depending on the beam angle of the light source, scattering effects can occur, which influence the recorded signal in LAPS-based differential measurements. To solve this problem, a novel illumination unit based on a field programmable gate array (FPGA) consisting of 16 small-sized tunable infrared laser-diode modules (LDMs) is developed. Due to the improved focus of the LDMs with a beam angle of only 2 mrad, undesirable scattering effects are minimized. Escherichia coli (E. coli) K12 bacteria are used as a test microorganism to study the extracellular acidification on the sensor surface. Furthermore, a salt bridge chamber is built up and integrated with the LAPS system enabling multi-chamber differential measurements with a single Ag/AgCl reference electrode.
Y1  - 2018
U6  - http://dx.doi.org/10.1002/pssa.201800058
SN  - 1862-6319
VL  - 215
IS  - 15
SP  - Article number 1800058
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Takenaga, Shoko
A1  - Wagner, Patrick
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system
JF  - Physica status solidi (a)
N2  - On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable “down times” during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements.
Y1  - 2016
U6  - http://dx.doi.org/10.1002/pssa.201533043
SN  - 1862-6300
VL  - 213
IS  - 6
SP  - 1479
EP  - 1485
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Takenaga, Shoko
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Differential imaging of the metabolism of bacteria and eukaryotic cells based on light-addressable potentiometric sensors
JF  - Electrochimica Acta
N2  - A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric sensor with an electrolyte/insulator/semiconductor (EIS) structure, which is able to monitor analyte concentrations of (bio-)chemical species in aqueous solutions in a spatially resolved way. Therefore, it is also an appropriate tool to record 2D-chemical images of concentration variations on the sensor surface. In the present work, two differential, LAPS-based measurement principles are introduced to determine the metabolic activity of Escherichia coli (E. coli) K12 and Chinese hamster ovary (CHO) cells as test microorganisms. Hereby, we focus on i) the determination of the extracellular acidification rate (ΔpH/min) after adding glucose solutions to the cell suspensions; and ii) recording the amplitude increase of the photocurrent (Iph) related to the produced acids from E. coli K12 bacteria and CHO cells on the sensor surface by 2D-chemical imaging. For this purpose, 3D-printed multi-chamber structures were developed and mounted on the planar sensor-chip surface to define four independent compartments, enabling differential measurements with varying cell concentrations. The differential concept allows eliminating unwanted drift effects and, with the four-chamber structures, measurements on the different cell concentrations were performed simultaneously, thus reducing also the overall measuring time.
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.electacta.2017.05.196
SN  - 0013-4686
VL  - 246
SP  - 234
EP  - 241
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Delle, Lotta E.
A1  - Huck, Christina
A1  - Bäcker, Matthias
A1  - Müller, Frank
A1  - Grandthyll, Samuel
A1  - Jacobs, Karin
A1  - Lilischkis, Rainer
A1  - Vu, Xuan T.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Thoelen, Roland
A1  - Weil, Maryam
A1  - Ingebrandt, Sven
T1  - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide
JF  - Physica status solidi (a)
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431863
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1327
EP  - 1334
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Doll, Theodor
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Engineering of functional interfaces / Theodor Doll ; Torsten Wagner ; Patrick Wagner ; Michael J. Schöning (eds.)
JF  - Physica status solidi (a)
Y1  - 2016
U6  - http://dx.doi.org/10.1002/pssa.201670641
SN  - 1862-6319
VL  - 213
IS  - 6
SP  - 1393
EP  - 1394
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Emons, H.
A1  - Baade, A.
A1  - Schöning, Michael Josef
T1  - Voltammetric determination of heavy metals in microvolumes of rain water
JF  - Electroanalysis. 12 (2000), H. 15
Y1  - 2000
SN  - 1040-0397
SP  - 1171
EP  - 1176
ER  - 
TY  - JOUR
A1  - Emons, H.
A1  - Glück, O.
A1  - Hüllenkremer, B.
A1  - Schöning, Michael Josef
T1  - Voltohmmetry as an alternative detection method at polycrystalline metal film electrodes
JF  - Electroanalysis. 13 (2001), H. 8-9
Y1  - 2001
SN  - 1040-0397
SP  - 677
EP  - 680
ER  - 
TY  - JOUR
A1  - Emons, H.
A1  - Glück, O.
A1  - Schöning, Michael Josef
T1  - Voltohmmetry – An alternative detection principle at ultrathin metal electrodes in solution
JF  - Chemical and biological sensors and analytical methods : proceedings of the international symposium / Sensor, Physical Electrochemistry, and Organic and Biological Electrochemistry Divisions. Ed.: M. Butler
Y1  - 2001
SN  - 1-56677-351-2
N1  - International Symposium: Chemical and Biological Sensors and Analytical Methods ; (2 : 2001.)
SP  - 1
EP  - 3
PB  - Electrochemical Society
CY  - Pennington, NJ
ER  - 
TY  - JOUR
A1  - Emons, H.
A1  - Hüllenkremer, B.
A1  - Schöning, Michael Josef
T1  - Detection of metal ions in aqueous solutions by voltohmmetry
JF  - Fresenius' Journal of Analytical Chemistry. 369 (2001), H. 1
Y1  - 2001
SN  - 0937-0633
SP  - 42
EP  - 46
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T
A1  - Mourzina, Y.
A1  - Levichev, S.
A1  - Furuichi, K.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Photocurable membranes for ion-selective light-addressable potentiometric sensors
JF  - Sensors and Actuators B. 85 (2002), H. 1-2
Y1  - 2002
SN  - 0925-4005
SP  - 79
EP  - 85
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Furuichi, K.
A1  - Iwasaki, H.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
T1  - Technology of photocurable polymeric membranes for integrated LAPS
JF  - Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan
Y1  - 2001
N1  - Chemical sensors; 17.2001 Suppl. B; East Asian Conference on Chemical Sensors ; (5, 2001; Nagasaki)
SP  - 66
EP  - 68
PB  - Japan Association of Chemical Sensors
CY  - Kasuga, Fukuoka-ken
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Furuichi, K.
A1  - Levichev, S.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Lithium sensor based on the laser scanning semiconductor transducer
JF  - Analytica Chimica Acta. 459 (2002), H. 1
Y1  - 2002
SN  - 0378-4304
SP  - 1
EP  - 9
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
A1  - Furuichi, K.
A1  - Levichev, S.
A1  - Vlasov, Y.
A1  - Iwasaki, H.
T1  - The double K+/Ca2+ sensor based on laser scanned silicon transducer (LSST) for multicomponent analysis
JF  - Talanta. 59 (2003), H. 4
Y1  - 2003
SN  - 0039-9140
SP  - 785
EP  - 795
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
A1  - Vlasov, Y.
A1  - Iwasaki, H.
T1  - The hybrid K+/Ca2+ sensor based on laser scanned silicon transducer for multi-component analysis
JF  - Proceedings of ICAS 2001, IUPAC [3rd] International Congress on Analytical Sciences 2001 : August 6 - 10, 2001, Waseda University, Tokyo
Y1  - 2002
N1  - International Congress on Analytical Sciences <2001, Tokyo> ; International Union of Pure and Applied Chemistry. Pure and applied chemistry ; 73,10. ; Analytical sciences ; 17.2001, special issue
SP  - i777
EP  - i780
PB  - Japan Society for Analytical Chemistry
CY  - Tokyo
ER  - 
TY  - CHAP
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
A1  - Vlasov, Y.
A1  - Iwasaki, H.
T1  - A multisensor based on laser scanned silicon transducer (LSST): development and properties
T2  - Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimarães, Portugal, September 21 - 24, 2003
Y1  - 2003
SP  - 72
EP  - 73
ER  - 
TY  - JOUR
A1  - Ermolenko, Y. E.
A1  - Yoshinobu, T.
A1  - Mourzina, Y. G.
A1  - Vlasov, Y. G.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Laserscanned transducer (LSST) as a multisensor system
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 457
EP  - 462
ER  - 
TY  - JOUR
A1  - Ermolenko, Y.E.
A1  - Vlasov, Y.G.
A1  - Kolodnikov, V.V.
A1  - Shabaldkin, D. A.
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
T1  - Diffusion of radioactive tracers (204Tl, 110mAg) and ionic conductivity in membrane materials for the chemical sensors
JF  - Advances in nuclear and radiochemistry : extended abstracts of papers presented at the Sixth International Conference on Nuclear and Radiochemistry (NRC-6), 29 August to 3 September 2004, Aachen, Germany ; in cooperation with University of Cologne, GDCh, FECS, OECD-NEA and IAEA / Syed M. Qaim ... (eds.).
Y1  - 2004
SN  - 3893363629
N1  - Schriften des Forschungszentrums Jülich Reihe Allgemeines und Interdisziplinäres ; 3. International Conference on Nuclear and Radiochemistry ; (6, 2004, Aachen)
SP  - 483
EP  - 485
PB  - Forschungszentrum Jülich, Zentralbibliothek
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Faßbender, F.
A1  - Schmitt, G.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
A1  - Buß, G.
A1  - Schultze, J. W.
T1  - Optimization of passivation layers for corrosion protection of silicon-based microelectrode arrays
JF  - Sensors and Actuators B. 68 (2000), H. 1-3
Y1  - 2000
SN  - 0925-4005
SP  - 128
EP  - 133
ER  - 
TY  - JOUR
A1  - Figueroa-Miranda, Gabriela
A1  - Feng, Lingyan
A1  - Shiu, Simon Chi-Chin
A1  - Dirkzwager, Roderick Marshall
A1  - Cheung, Yee-Wai
A1  - Tanner, Julian Alexander
A1  - Schöning, Michael Josef
A1  - Offenhäusser, Andreas
A1  - Mayer, Dirk
T1  - Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability
JF  - Sensor and Actuators B: Chemical
N2  - Malaria infection remains a significant risk for much of the population of tropical and subtropical areas, particularly in developing countries. Therefore, it is of high importance to develop sensitive, accurate and inexpensive malaria diagnosis tests. Here, we present a novel aptamer-based electrochemical biosensor (aptasensor) for malaria detection by impedance spectroscopy, through the specific recognition between a highly discriminatory DNA aptamer and its target Plasmodium falciparum lactate dehydrogenase (PfLDH). Interestingly, due to the isoelectric point (pI) of PfLDH, the aptasensor response showed an adjustable detection range based on the different protein net-charge at variable pH environments. The specific aptamer recognition allows sensitive protein detection with an expanded detection range and a low detection limit, as well as a high specificity for PfLDH compared to analogous proteins. The specific feasibility of the aptasensor is further demonstrated by detection of the target PfLDH in human serum. Furthermore, the aptasensor can be easily regenerated and thus applied for multiple usages. The robustness, sensitivity, and reusability of the presented aptasensor make it a promising candidate for point-of-care diagnostic systems.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.snb.2017.07.117
SN  - 0925-4005
VL  - 255
IS  - P1
SP  - 235
EP  - 243
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Furuichi, K.
A1  - Yoshinobu, T.
A1  - Ermelenko, T.
A1  - Mourzina, Y.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - Simultaneous visualization of multiple ions by the chemical imaging sensor
JF  - Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan
Y1  - 2001
N1  - Chemical sensors; 17.2001 Suppl. B; East Asian Conference on Chemical Sensors ; (5, 2001; Nagasaki)
SP  - 399
EP  - 401
PB  - Japan Association of Chemical Sensors
CY  - Kasuga, Fukuoka-ken
ER  - 
TY  - JOUR
A1  - Gamella, Maria
A1  - Zakharchenko, Andrey
A1  - Guz, Nataliia
A1  - Masi, Madeline
A1  - Minko, Sergiy
A1  - Kolpashchikov, Dmitry M.
A1  - Iken, Heiko
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - DNA computing system activated by electrochemically triggered DNA realease from a polymer-brush-modified electrode array
JF  - Electroanalysis
N2  - An array of four independently wired indium tin oxide (ITO) electrodes was used for electrochemically stimulated DNA release and activation of DNA-based Identity, AND and XOR logic gates. Single-stranded DNA molecules were loaded on the mixed poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA)/poly(methacrylic acid) (PMAA) brush covalently attached to the ITO electrodes. The DNA deposition was performed at pH 5.0 when the polymer brush is positively charged due to protonation of tertiary amino groups in PDMAEMA, thus resulting in electrostatic attraction of the negatively charged DNA. By applying electrolysis at −1.0 V(vs. Ag/AgCl reference) electrochemical oxygen reduction resulted in the consumption of hydrogen ions and local pH increase near the electrode surface. The process resulted in recharging the polymer brush to the negative state due to dissociation of carboxylic groups of PMAA, thus repulsing the negatively charged DNA and releasing it from the electrode surface. The DNA release was performed in various combinations from different electrodes in the array assembly. The released DNA operated as input signals for activation of the Boolean logic gates. The developed system represents a step forward in DNA computing, combining for the first time DNA chemical processes with electronic input signals.
Y1  - 2017
U6  - http://dx.doi.org/10.1002/elan.201600389
SN  - 1521-4109
VL  - 29
IS  - 2
SP  - 398
EP  - 408
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Gasparyan, F. V.
A1  - Poghossian, Arshak
A1  - Vitusevich, S. A.
A1  - Petrychuk, M. V.
A1  - Sydoruk, V. A.
A1  - Surmalyan, A. V.
A1  - Siqueira, J. R.
A1  - Oliveira, O. N.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Low Frequency Noise In Electrolyte-Gate Field-Effect Devices Functionalized With Dendrimer/Carbon-Nanotube Multilayers
JF  - Noise and fluctuations : 20th International Conference on Noise and Fluctuations, ICNF 2009, Pisa, Italy, 14 - 19 June 2009 / ed. Massimo Macucci; Giovanni Basso
Y1  - 2009
SN  - 9780735406650
N1  - AIP conference proceedings ; 1129 ; International Conference on Noise and Fluctuations ; (20, 2009, Pisa)
SP  - 133
EP  - 136
PB  - American Inst. of Physics
CY  - Melville, NY
ER  - 
TY  - JOUR
A1  - Gasparyan, F.V.
A1  - Vitusevich, S.A.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Modified charge fluctuation noise model for electrolyte-insulator-semiconductor devices
JF  - Modern Physics Letters B (MPLB). 25 (2011), H. 11
Y1  - 2011
SN  - 0217-9849
SP  - 831
EP  - 840
PB  - World Scientific Publ.
CY  - Singapur
ER  - 
TY  - JOUR
A1  - Gasparyan, Ferdinand V.
A1  - Poghossian, Arshak
A1  - Vitusevich, Svetlana A.
A1  - Petrychuk, Mykhaylo V.
A1  - Sydoruk, Viktor A.
A1  - Siqueira, José R. Jr.
A1  - Oliveira, Osvaldo N. Jr.
A1  - Offenhäusser, Andreas
A1  - Schöning, Michael Josef
T1  - Low-Frequency Noise in Field-Effect Devices Functionalized With Dendrimer/Carbon-Nanotube Multilayers
JF  - IEEE Sensors Journal. 11 (2011), H. 1
Y1  - 2011
SN  - 1530-437X
SP  - 142
EP  - 149
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Ge, B.
A1  - Meyer, T.
A1  - Schöning, Michael Josef
A1  - Wollenberger, U.
A1  - Lisdat, F., 
T1  - Cytochrome c‘ from Chromatium vinosum on gold electrodes
JF  - Electrochemistry Communications. 2 (2000), H. 8
Y1  - 2000
SN  - 1388-2481
SP  - 557
EP  - 561
ER  - 
TY  - JOUR
A1  - Givanoudi, Stella
A1  - Cornelis, Peter
A1  - Rasschaert, Geertrui
A1  - Wackers, Gideon
A1  - Iken, Heiko
A1  - Rolka, David
A1  - Yongabi, Derick
A1  - Robbens, Johan
A1  - Schöning, Michael Josef
A1  - Heyndrickx, Marc
A1  - Wagner, Patrick
T1  - Selective Campylobacter detection and quantification in poultry: A sensor tool for detecting the cause of a common zoonosis at its source
JF  - Sensors and Actuators B: Chemical
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.snb.2021.129484
SN  - 0925-4005
IS  - In Press, Journal Pre-proof
SP  - Article 129484
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Grinsven, B. van
A1  - Bon, N. vanden
A1  - Grieten, L.
A1  - Murib, M.
A1  - Janssen, S. D.
A1  - Haenen, K.
A1  - Schneider, E.
A1  - Ingebrandt, E.
A1  - Schöning, Michael Josef
A1  - Vermeeren, V.
A1  - Ameloot, M.
A1  - Michiels, L.
A1  - Thoelen, R.
A1  - Ceuninck, W. de
A1  - Wagner, P.
T1  - Rapid assessment of the stability of DNA duplexes by impedimetric real-time monitoring of chemically induced denaturation
JF  - Lab on a Chip
Y1  - 2011
SN  - 1473-0197
VL  - 11
IS  - 9
SP  - 1656
EP  - 1663
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Grinsven, Bart van
A1  - Bon, Natalie vanden
A1  - Strauven, Hannelore
A1  - Grieten, Lars
A1  - Murib, Mohammed
A1  - Jiménez Monroy, Kathia L.
A1  - Janssens, Stoffel D.
A1  - Haenen, Ken
A1  - Schöning, Michael Josef
A1  - Vermeeren, Veronique
A1  - Ameloot, Marcel
A1  - Michiels, Luc
A1  - Thoelen, Ronald
A1  - Ceuninck, Ward de
A1  - Wagner, Patrick
T1  - Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA.
JF  - ACS Nano
N2  - In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA.
Y1  - 2012
U6  - http://dx.doi.org/10.1021/nn300147e
SN  - 1936-086X
VL  - 6
IS  - 3
SP  - 2712
EP  - 2721
PB  - ACS Publications
CY  - Washington, DC
ER  -