TY - CHAP A1 - Bhattarai, Aroj A1 - Frotscher, Ralf A1 - Staat, Manfred ED - Natal Jorge, Renato T1 - Significance of fibre geometry on passive-active response of pelvic muscles to evaluate pelvic dysfunction T2 - BioMedWomen: Proceedings of the international conference on clinical and bioengineering for women's health Y1 - 2016 SN - 978-1-138-02910-1 SP - 185 EP - 188 PB - CRC Press CY - Boca Raton ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Computational Analysis of Pelvic Floor Dysfunction T2 - Women's Health and Biomechanics N2 - Pelvic floor dysfunction (PFD) is characterized by the failure of the levator ani (LA) muscle to maintain the pelvic hiatus, resulting in the descent of the pelvic organs below the pubococcygeal line. This chapter adopts the modified Humphrey material model to consider the effect of the muscle fiber on passive stretching of the LA muscle. The deformation of the LA muscle subjected to intra-abdominal pressure during Valsalva maneuver is compared with the magnetic resonance imaging (MRI) examination of a nulliparous female. Numerical result shows that the fiber-based Humphrey model simulates the muscle behavior better than isotropic constitutive models. Greater posterior movement of the LA muscle widens the levator hiatus due to lack of support from the anococcygeal ligament and the perineal structure as a consequence of birth-related injury and aging. Old and multiparous females with uncontrolled urogenital and rectal hiatus tend to develop PFDs such as prolapse and incontinence. KW - Pelvic muscle KW - Muscle fibers KW - Passive stretching KW - Pelvic floor dysfunction Y1 - 2018 SN - 978-3-319-71574-2 U6 - http://dx.doi.org/10.1007/978-3-319-71574-2_17 N1 - Lecture Notes in Computational Vision and Biomechanics, vol 29 SP - 217 EP - 230 PB - Springer CY - Cham ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Horbach, Andreas A1 - Staat, Manfred A1 - Kowalczyk, Wojciech A1 - Tran, Thanh Ngoc T1 - Virgin passive colon biomechanics and a literature review of active contraction constitutive models JF - Biomechanics N2 - The objective of this paper is to present our findings on the biomechanical aspects of the virgin passive anisotropic hyperelasticity of the porcine colon based on equibiaxial tensile experiments. Firstly, the characterization of the intestine tissues is discussed for a nearly incompressible hyperelastic fiber-reinforced Holzapfel–Gasser–Ogden constitutive model in virgin passive loading conditions. The stability of the evaluated material parameters is checked for the polyconvexity of the adopted strain energy function using positive eigenvalue constraints of the Hessian matrix with MATLAB. The constitutive material description of the intestine with two collagen fibers in the submucosal and muscular layer each has been implemented in the FORTRAN platform of the commercial finite element software LS-DYNA, and two equibiaxial tensile simulations are presented to validate the results with the optical strain images obtained from the experiments. Furthermore, this paper also reviews the existing models of the active smooth muscle cells, but these models have not been computationally studied here. The review part shows that the constitutive models originally developed for the active contraction of skeletal muscle based on Hill’s three-element model, Murphy’s four-state cross-bridge chemical kinetic model and Huxley’s sliding-filament hypothesis, which are mainly used for arteries, are appropriate for numerical contraction numerical analysis of the large intestine. KW - virgin passive KW - strain energy function KW - smooth muscle contraction KW - viscoelasticity KW - damage Y1 - 2022 U6 - http://dx.doi.org/10.3390/biomechanics2020013 SN - 2673-7078 VL - 2 IS - 2 SP - 138 EP - 157 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Jabbari, Medisa A1 - Anding, Ralf A1 - Staat, Manfred T1 - Surgical treatment of vaginal vault prolapse using different prosthetic mesh implants: a finite element analysis JF - tm - Technisches Messen N2 - Particularly multiparous elderly women may suffer from vaginal vault prolapse after hysterectomy due to weak support from lax apical ligaments. A decreased amount of estrogen and progesterone in older age is assumed to remodel the collagen thereby reducing tissue stiffness. Sacrocolpopexy is either performed as open or laparoscopic surgery using prosthetic mesh implants to substitute lax ligaments. Y-shaped mesh models (DynaMesh, Gynemesh, and Ultrapro) are implanted in a 3D female pelvic floor finite element model in the extraperitoneal space from the vaginal cuff to the first sacral (S1) bone below promontory. Numerical simulations are conducted during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues are modeled as incompressible, isotropic hyperelastic materials whereas the meshes are modeled either as orthotropic linear elastic or as isotropic hyperlastic materials. The positions of the vaginal cuff and the bladder base are calculated from the pubococcygeal line for female pelvic floor at rest, for prolapse and after repair using the three meshes. Due to mesh mechanics and mesh pore deformation along the loaded direction, the DynaMesh with regular rectangular mesh pores is found to provide better mechanical support to the organs than the Gynemesh and the Ultrapro with irregular hexagonal mesh pores. Insbesondere ältere, mehrgebährende Frauen leiden häufiger an einem Scheidenvorfall nach einer Hysterektomie aufgrund der schwachen Unterstützung durch laxe apikale Bänder. Es wird angenommen, dass eine verringerte Menge an Östrogen und Progesteron im höheren Alter das Kollagen umformt, wodurch die Gewebesteifigkeit reduziert wird. Die Sakrokolpopexie ist eine offene oder laparoskopische Operation, die mit prothetischen Netzimplantaten durchgeführt wird, um laxe Bänder zu ersetzen. Y-förmige Netzmodelle (DynaMesh, Gynemesh und Ultrapro) werden in einem 3D-Modell des weiblichen Beckenbodens im extraperitonealen Raum vom Vaginalstumpf bis zum Promontorium implantiert. Numerische Simulationen werden während des Valsalva-Manövers mit geschwächtem Gewebe durchgeführt, das durch eine reduzierte Gewebesteifigkeit modelliert wird. Die Gewebe werden als inkompressible, isotrop hyperelastische Materialien modelliert, während die Netze entweder als orthotrope linear elastische oder als isotrope hyperlastische Materialien modelliert werden. Die Positionen des Vaginalstumpfs, der Blase und der Harnröhrenachse werden anhand der Pubococcygeallinie aus der Ruhelage, für den Prolaps und nach der Reparatur unter Verwendung der drei Netze berechnet. Aufgrund der Netzmechanik und der Netzporenverformung bietet das DynaMesh mit regelmäßigen rechteckigen Netzporen eine bessere mechanische Unterstützung und eine Neupositionierung des Scheidengewölbes, der Blase und der Urethraachse als Gynemesh und Ultrapro mit unregelmäßigen hexagonalen Netzporen. Y1 - 2018 U6 - http://dx.doi.org/10.1515/teme-2017-0115 SN - 2196-7113 VL - 85 IS - 5 SP - 331 EP - 342 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Bhattarai, Aroj A1 - May, Charlotte Anabell A1 - Staat, Manfred A1 - Kowalczyk, Wojciech A1 - Tran, Thanh Ngoc T1 - Layer-specific damage modeling of porcine large intestine under biaxial tension JF - Bioengineering N2 - The mechanical behavior of the large intestine beyond the ultimate stress has never been investigated. Stretching beyond the ultimate stress may drastically impair the tissue microstructure, which consequently weakens its healthy state functions of absorption, temporary storage, and transportation for defecation. Due to closely similar microstructure and function with humans, biaxial tensile experiments on the porcine large intestine have been performed in this study. In this paper, we report hyperelastic characterization of the large intestine based on experiments in 102 specimens. We also report the theoretical analysis of the experimental results, including an exponential damage evolution function. The fracture energies and the threshold stresses are set as damage material parameters for the longitudinal muscular, the circumferential muscular and the submucosal collagenous layers. A biaxial tensile simulation of a linear brick element has been performed to validate the applicability of the estimated material parameters. The model successfully simulates the biomechanical response of the large intestine under physiological and non-physiological loads. KW - biaxial tensile experiment KW - anisotropy KW - hyperelastic KW - constitutive modeling KW - damage Y1 - 2022 U6 - http://dx.doi.org/10.3390/bioengineering9100528 SN - 2306-5354 N1 - Der Artikel gehört zum Sonderheft "Computational Biomechanics" VL - 9 IS - 10, Early Access SP - 1 EP - 17 PB - MDPI CY - Basel ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Erni, Daniel T1 - Female pelvic floor dysfunction: progress weakening of the support system T2 - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen N2 - The structure of the female pelvic floor (PF) is an inter-related system of bony pelvis,muscles, pelvic organs, fascias, ligaments, and nerves with multiple functions. Mechanically, thepelvic organ support system are of two types: (I) supporting system of the levator ani (LA) muscle,and (II) the suspension system of the endopelvic fascia condensation [1], [2]. Significantdenervation injury to the pelvic musculature, depolimerization of the collagen fibrils of the softvaginal hammock, cervical ring and ligaments during pregnancy and vaginal delivery weakens thenormal functions of the pelvic floor. Pelvic organ prolapse, incontinence, sexual dysfunction aresome of the dysfunctions which increases progressively with age and menopause due toweakened support system according to the Integral theory [3]. An improved 3D finite elementmodel of the female pelvic floor as shown in Fig. 1 is constructed that: (I) considers the realisticsupport of the organs to the pelvic side walls, (II) employs the improvement of our previous FEmodel [4], [5] along with the patient based geometries, (III) incorporates the realistic anatomy andboundary conditions of the endopelvic (pubocervical and rectovaginal) fascia, and (IV) considersvarying stiffness of the endopelvic fascia in the craniocaudal direction [3]. Several computationsare carried out on the presented computational model with healthy and damaged supportingtissues, and comparisons are made to understand the physiopathology of the female PF disorders. Y1 - 2016 U6 - http://dx.doi.org/10.17185/duepublico/40821 SP - 11 EP - 12 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Staat, Manfred T1 - Modelling of Soft Connective Tissues to Investigate Female Pelvic Floor Dysfunctions JF - Computational and Mathematical Methods in Medicine N2 - After menopause, decreased levels of estrogen and progesterone remodel the collagen of the soft tissues thereby reducing their stiffness. Stress urinary incontinence is associated with involuntary urine leakage due to pathological movement of the pelvic organs resulting from lax suspension system, fasciae, and ligaments. This study compares the changes in the orientation and position of the female pelvic organs due to weakened fasciae, ligaments, and their combined laxity. A mixture theory weighted by respective volume fraction of elastin-collagen fibre compound (5%), adipose tissue (85%), and smooth muscle (5%) is adopted to characterize the mechanical behaviour of the fascia. The load carrying response (other than the functional response to the pelvic organs) of each fascia component, pelvic organs, muscles, and ligaments are assumed to be isotropic, hyperelastic, and incompressible. Finite element simulations are conducted during Valsalva manoeuvre with weakened tissues modelled by reduced tissue stiffness. A significant dislocation of the urethrovesical junction is observed due to weakness of the fascia (13.89 mm) compared to the ligaments (5.47 mm). The dynamics of the pelvic floor observed in this study during Valsalva manoeuvre is associated with urethral-bladder hypermobility, greater levator plate angulation, and positive Q-tip test which are observed in incontinent females. Y1 - 2018 U6 - http://dx.doi.org/10.1155/2018/9518076 SN - 1748-6718 VL - 2018 IS - Article ID 9518076 SP - 1 EP - 16 PB - Hindawi CY - New York, NY ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Mechanics of soft tissue reactions to textile mesh implants T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - For pelvic floor disorders that cannot be treated with non-surgical procedures, minimally invasive surgery has become a more frequent and safer repair procedure. More than 20 million prosthetic meshes are implanted each year worldwide. The simple selection of a single synthetic mesh construction for any level and type of pelvic floor dysfunctions without adopting the design to specific requirements increase the risks for mesh related complications. Adverse events are closely related to chronic foreign body reaction, with enhanced formation of scar tissue around the surgical meshes, manifested as pain, mesh erosion in adjacent structures (with organ tissue cut), mesh shrinkage, mesh rejection and eventually recurrence. Such events, especially scar formation depend on effective porosity of the mesh, which decreases discontinuously at a critical stretch when pore areas decrease making the surgical reconstruction ineffective that further augments the re-operation costs. The extent of fibrotic reaction is increased with higher amount of foreign body material, larger surface, small pore size or with inadequate textile elasticity. Standardized studies of different meshes are essential to evaluate influencing factors for the failure and success of the reconstruction. Measurements of elasticity and tensile strength have to consider the mesh anisotropy as result of the textile structure. An appropriate mesh then should show some integration with limited scar reaction and preserved pores that are filled with local fat tissue. This chapter reviews various tissue reactions to different monofilament mesh implants that are used for incontinence and hernia repairs and study their mechanical behavior. This helps to predict the functional and biological outcomes after tissue reinforcement with meshes and permits further optimization of the meshes for the specific indications to improve the success of the surgical treatment. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_11 SP - 251 EP - 275 PB - Springer CY - Singapore ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Fernandes, P.R. ED - Tavares, J. M. T1 - Pectopexy to repair vaginal vault prolapse: a finite element approach T2 - Proceedings CMBBE 2018 N2 - The vaginal prolapse after hysterectomy (removal of the uterus) is often associated with the prolapse of the vaginal vault, rectum, bladder, urethra or small bowel. Minimally invasive surgery such as laparoscopic sacrocolpopexy and pectopexy are widely performed for the treatment of the vaginal prolapse with weakly supported vaginal vault after hysterectomy using prosthetic mesh implants to support (or strengthen) lax apical ligaments. Implants of different shape, size and polymers are selected depending on the patient’s anatomy and the surgeon’s preference. In this computational study on pectopexy, DynaMesh®-PRP soft, GYNECARE GYNEMESH® PS Nonabsorbable PROLENE® soft and Ultrapro® are tested in a 3D finite element model of the female pelvic floor. The mesh model is implanted into the extraperitoneal space and sutured to the vaginal stump with a bilateral fixation to the iliopectineal ligament at both sides. Numerical simulations are conducted at rest, after surgery and during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues and prosthetic meshes are modeled as incompressible, isotropic hyperelastic materials. The positions of the organs are calculated with respect to the pubococcygeal line (PCL) for female pelvic floor at rest, after repair and during Valsalva maneuver using the three meshes. Y1 - 2018 N1 - 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 3rd Conference on Imaging and Visualization. CMBBE 2018. 26-29 March 2018, Lisbon, Portugal ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Staat, Manfred T1 - Computational comparison of different textile implants to correct apical prolapse in females JF - Current Directions in Biomedical Engineering N2 - Prosthetic textile implants of different shapes, sizes and polymers are used to correct the apical prolapse after hysterectomy (removal of the uterus). The selection of the implant before or during minimally invasive surgery depends on the patient’s anatomical defect, intended function after reconstruction and most importantly the surgeon’s preference. Weakness or damage of the supporting tissues during childbirth, menopause or previous pelvic surgeries may put females in higher risk of prolapse. Numerical simulations of reconstructed pelvic floor with weakened tissues and organ supported by textile product models: DynaMesh®-PRS soft, DynaMesh®-PRP soft and DynaMesh®-CESA from FEG Textiletechnik mbH, Germany are compared. Y1 - 2018 U6 - http://dx.doi.org/10.1515/cdbme-2018-0159 VL - 4 IS - 1 SP - 661 EP - 664 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Staat, Manfred T1 - A computational study of organ relocation after laparoscopic pectopexy to repair posthysterectomy vaginal vault prolapse JF - Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization Y1 - 2019 U6 - http://dx.doi.org/10.1080/21681163.2019.1670095 SN - 2168-1171 PB - Taylor & Francis CY - London ER - TY - BOOK A1 - Bialonski, Stephan T1 - Inferring complex networks from time series of dynamical systems: Pitfalls, misinterpretations, and possible solutions Y1 - 2012 N1 - Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Diss., 2012 PB - Universitäts- und Landesbibliothek Bonn CY - Bonn ER - TY - CHAP A1 - Bialonski, Stephan T1 - Are interaction clusters in epileptic networks predictive of seizures? T2 - Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics Y1 - 2016 SN - 978-143983886-0 SP - 349 EP - 355 PB - CRC Press ER - TY - JOUR A1 - Bialonski, Stephan A1 - Allefeld, C. A1 - Wellmer, J. A1 - Elger, C. A1 - Lehnertz, K. T1 - An approach to identify synchronization clusters within the epileptic network JF - Klinische Neurophysiologie Y1 - 2008 U6 - http://dx.doi.org/10.1055/s-2008-1072881 VL - 39 IS - 1 SP - A79 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Ansmann, Gerrit A1 - Kantz, Holger T1 - Data-driven prediction and prevention of extreme events in a spatially extended excitable system JF - Physical Review E Y1 - 2015 U6 - http://dx.doi.org/10.1103/PhysRevE.92.042910 SN - 2470-0053 VL - 92 IS - 4 SP - 042910 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Caron, David A. A1 - Schloen, Julia A1 - Feudel, Ulrike A1 - Kantz, Holger A1 - Moorthi, Stefanie D. T1 - Phytoplankton dynamics in the Southern California Bight indicate a complex mixture of transport and biology JF - Journal of Plankton Research N2 - The stimulation and dominance of potentially harmful phytoplankton taxa at a given locale and time are determined by local environmental conditions as well as by transport to or from neighboring regions. The present study investigated the occurrence of common harmful algal bloom (HAB) taxa within the Southern California Bight, using cross-correlation functions to determine potential dependencies between HAB taxa and environmental factors, and potential links to algal transport via local hydrography and currents. A simulation study, in which Lagrangian particles were released, was used to assess travel times due to advection by prevailing ocean currents in the bight. Our results indicate that transport of some taxa may be an important mechanism for the expansion of their distributions into other regions, which was supported by mean travel times derived from our simulation study and other literature on ocean currents in the Southern California Bight. In other cases, however, phytoplankton dynamics were rather linked to local environmental conditions, including coastal upwelling events. Overall, our study shows that complex current patterns in the Southern California Bight may contribute significantly to the formation and expansion of HABs in addition to local environmental factors determining the spatiotemporal dynamics of phytoplankton blooms. Y1 - 2016 U6 - http://dx.doi.org/10.1093/plankt/fbv122 SN - 1464-3774 VL - 38 IS - 4 SP - 1077 EP - 1091 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Bialonski, Stephan A1 - Horstmann, Marie-Therese A1 - Lehnertz, Klaus T1 - From brain to earth and climate systems: Small-world interaction networks or not? JF - Chaos: An Interdisciplinary Journal of Nonlinear Science N2 - We consider recent reports on small-world topologies of interaction networks derived from the dynamics of spatially extended systems that are investigated in diverse scientific fields such as neurosciences, geophysics, or meteorology. With numerical simulations that mimic typical experimental situations, we have identified an important constraint when characterizing such networks: indications of a small-world topology can be expected solely due to the spatial sampling of the system along with the commonly used time series analysis based approaches to network characterization. Y1 - 2010 U6 - http://dx.doi.org/10.1063/1.3360561 SN - 1089-7682 VL - 20 IS - 1 PB - AIP Publishing CY - Melville, NY ER - TY - JOUR A1 - Bialonski, Stephan A1 - Lehnertz, Klaus T1 - Assortative mixing in functional brain networks during epileptic seizures JF - Chaos: An Interdisciplinary Journal of Nonlinear Science Y1 - 2013 U6 - http://dx.doi.org/10.1063/1.4821915 VL - 23 IS - 3 SP - 033139 ER - TY - CHAP A1 - Bialonski, Stephan A1 - Lehnertz, Klaus T1 - From time series to complex networks: an overview T2 - Recent Advances in Predicting and Preventing Epileptic Seizures: Proceedings of the 5th International Workshop on Seizure Prediction N2 - The network approach towards the analysis of the dynamics of complex systems has been successfully applied in a multitude of studies in the neurosciences and has yielded fascinating insights. With this approach, a complex system is considered to be composed of different constituents which interact with each other. Interaction structures can be compactly represented in interaction networks. In this contribution, we present a brief overview about how interaction networks are derived from multivariate time series, about basic network characteristics, and about challenges associated with this analysis approach. Y1 - 2013 SN - 978-981-4525-36-7 U6 - http://dx.doi.org/10.1142/9789814525350_0010 SP - 132 EP - 147 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Lehnertz, Klaus T1 - Identifying phase synchronization clusters in spatially extended dynamical systems JF - Physical Review E Y1 - 2006 U6 - http://dx.doi.org/10.1103/PhysRevE.74.051909 SN - 2470-0053 VL - 74 IS - 5 SP - 051909 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Schindler, K. A1 - Elger, C. E. A1 - Lehnertz, Klaus T1 - Lateralized characteristics of the evolution of EEG correlation during focal onset seizures: a mechanism to prevent secondary generalization? JF - Epilepsia N2 - Rationale: Previous studies [Topolnik et al., Cereb Cortex 2003; 13: 883; Schindler et al., Brain 2007; 130: 65] indicate that the termination of focal onset seizures may be causally related to an increase of global neuronal correlation during the second half of the seizures. This increase was observed to occur earlier in complex partial seizures than in secondarily generalized seizures. We here address the question whether such an increase of neuronal correlation prior to seizure end is indeed a global phenomenon, involving both hemispheres or whether there are side-specific differences. Methods: We analyzed 20 focal onset seizures (10 complex partial, 10 secondarily generalized seizures) recorded in 13 patients who underwent presurgical evaluation of focal epilepsies of different origin. EEG was recorded intracranially from bilaterally implanted subdural strip and intrahippocampal depth electrodes. Utilizing a moving window approach, we investigated the evolution of the maximum cross correlation for all channel combinations during seizures. For each moving window the mean value of the maximum cross correlation (MCC) between all electrode contacts was computed separately for each hemisphere. After normalization of seizure durations, MCC values of the ipsi- and contralateral hemisphere for all seizures were determined. Results: We observed that the MCC of the contralateral hemisphere in complex partial seizures increased during the first half of the seizure, whereas, for the same time interval, the MCC of the ipsilateral hemisphere even declined below the level of the pre-seizure period. In contrast, no significant differences between both hemispheres could be observed for secondarily generalized seizures where both hemispheres showed a simultaneous increase of MCC during the second half of the seizures. The level of MCC for the contralateral hemisphere was higher for complex partial seizures than for secondarily generalized seizures during the first half of the seizure. Conclusions: Our findings indicate that there are indeed lateralized differences in the evolution of global neuronal correlation during complex partial and secondarily generalized seizures. The observed contralateral increase of neuronal correlation during complex partial seizures might indicate an emerging self-organizing mechanism for preventing the spread of seizure activity. Y1 - 2008 SN - 0013-9580 VL - 49 SP - 11 EP - 11 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Wellmer, Jörg A1 - Elger, Christian E. A1 - Lehnertz, Klaus T1 - Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis JF - Epilepsia Y1 - 2006 SN - 0013-9580 VL - 47 SP - 36 ER - TY - JOUR A1 - Bialonski, Stephan A1 - Wendler, Martin A1 - Lehnertz, Klaus T1 - Unraveling spurious properties of interaction networks with tailored random networks JF - Plos one N2 - We investigate interaction networks that we derive from multivariate time series with methods frequently employed in diverse scientific fields such as biology, quantitative finance, physics, earth and climate sciences, and the neurosciences. Mimicking experimental situations, we generate time series with finite length and varying frequency content but from independent stochastic processes. Using the correlation coefficient and the maximum cross-correlation, we estimate interdependencies between these time series. With clustering coefficient and average shortest path length, we observe unweighted interaction networks, derived via thresholding the values of interdependence, to possess non-trivial topologies as compared to Erdös-Rényi networks, which would indicate small-world characteristics. These topologies reflect the mostly unavoidable finiteness of the data, which limits the reliability of typically used estimators of signal interdependence. We propose random networks that are tailored to the way interaction networks are derived from empirical data. Through an exemplary investigation of multichannel electroencephalographic recordings of epileptic seizures – known for their complex spatial and temporal dynamics – we show that such random networks help to distinguish network properties of interdependence structures related to seizure dynamics from those spuriously induced by the applied methods of analysis. Y1 - 2011 U6 - http://dx.doi.org/10.1371/journal.pone.0022826 VL - 6 IS - 8 PB - Plos CY - San Francisco ER - TY - JOUR A1 - Biener, Ernst T1 - Rehabilitation of old gravity dams JF - [Transactions] : proceedings of fifteenth international congress on large dams ; 24 - 28 Juin 1985, Lausanne, Suisse = Quinzieme Congres International des Grands Barrages. - Bd. 4 Y1 - 1985 N1 - International Congress on Large Dams <15, 1985, Paris> SP - Q 59, R.2, S. 21 EP - 23 PB - Intern. Commission on Large Dams CY - Paris ER - TY - JOUR A1 - Biener, Ernst A1 - Bethke, H. A1 - Sasse, T. A1 - Wernhoff, T. T1 - Alternative landfill capping using locally available recycled material JF - Land contamination & reclamation. 14 (2003), H. 4 Y1 - 2003 SN - 0967-0513 SP - 419 EP - 427 ER - TY - JOUR A1 - Biener, Ernst A1 - Boyken, P. A1 - Sasse, T. T1 - Integrated dredged material management system of Bremen-Seehausen JF - Sardinia 97 : proceedings ; [13 - 17 October 1997, S. Margherita di Pula - Cagliari, Sardinia, Italy] / Sixth International Landfill Symposium. Ed.: Thomas H. Christensen... - Bd. 5 : Landfill regulations, waste characteristics, landfilling in middle and lower income countries, industrial wastes and monolandfills Y1 - 1997 N1 - International Landfill Symposium <6, 1997, Santa Margherita, Pula> SP - 497 EP - 502 PB - CISA, Environmental Sanitary Engineering Centre CY - Cagliari ER - TY - JOUR A1 - Biener, Ernst A1 - Boyken, P. A1 - Sasse, T. A1 - Arnold, J. T1 - Geotechnical aspects of the construction of the integrated harbour sludge management system in Bremen-Seehausen / P. Boyken ; E. Biener ; T. Sasse ; J. Arnold JF - Geotechnical engineering for transportation infrastructure : proceedings of the twelfth European Conference on Soil Mechanics and Geotechnical Engineering, Amsterdam, Netherlands, 7 - 10 June 1999 ; theory and practice, planning and design, construction and maintenance. - Vol. 2 Y1 - 1999 SN - 90-5809-049-3 N1 - European Conference on Soil Mechanics and Geotechnical Engineering <12, 1999, Amsterdam> SP - 909 EP - 914 PB - Balkema CY - Rotterdam ER - TY - JOUR A1 - Biener, Ernst A1 - Rouvé, G. T1 - Behaviour and maintenance of some old masonry gravity dams JF - Safety of dams : proceedings of the International Conference on Safety of Dams, Coimbra, 23-28 April 1984 / ed. by J. Laginha Serafim. - [Hauptbd.] Y1 - 1984 SN - 90-6191-522-8 N1 - International Conference on Safety of Dams <1984, Coimbra> ; ISBN Set: 90-6191-521-X SP - 101 EP - 106 PB - Rotterdam [u.a.] CY - Balkema ER - TY - JOUR A1 - Biener, Ernst A1 - Sasse, T. T1 - Construction and rehabilitation of landfill shafts JF - Sardinia 93 : Fourth International Landfill Symposium "Barrier systems, environmental aspects, upgrading and remediation, siting, monofills, effects of waste pretreatment, landfilling in developing countries" ; 11 - 15 October 1993, S. Margherita di Pula (Cagliari), Sardinia, Italy ; proceedings / coord. by Thomas H. Christensen ... - Bd. 1 Y1 - 1993 N1 - International Landfill Symposium <4, 1993, Santa Margherita, Pula> SP - 451 EP - 460 PB - CISA, Environmental Sanitary Engineering Centre CY - Cagliari ER - TY - JOUR A1 - Biener, Ernst A1 - Sasse, T. T1 - Quality improvements in the construction of multilayer covers JF - Géologie et confinement des déchets toxiques : actes du symposium international, 8 - 11 juin 1993 / GEOCONFINE 93, Montpellier, France. Réd. Marcel Arnould Y1 - 1993 SN - 90-5410-330-2 N1 - Geoconfine <1993, Montpellier> ; Paralellt.: Geology and confinement of toxic wastes SP - 309 EP - 312 PB - Balkema CY - Rotterdam [u.a.] ER - TY - JOUR A1 - Biener, Ernst A1 - Sasse, T. T1 - Construction of composite lining systems under unfavourable weather conditions JF - Landfilling of waste: barriers / ed. by T. H. Christensen; R. Cossu; R. Stegmann. - 1. Aufl. Y1 - 1994 SN - 0419159908 SP - 183 EP - 200 PB - Spon CY - London [u.a.] ER - TY - JOUR A1 - Biener, Ernst A1 - Sasse, T. T1 - Experience with new techniques in slurry cutoff wall construction JF - ISWA 88, proceedings of the 5th International Solid Wastes Conference : September 11 - 16th, 1988, Copenhagen, Denmark / ed. by Lizzi Andersen ... - Vol. 1 : Oral presentations Y1 - 1988 SN - 0-12-058451-4 N1 - International Solid Wastes Conference <5, 1988, København> ; International Solid Wastes and Public Cleansing Association SP - 41 EP - 46 PB - Acad. Press CY - London [u.a.] ER - TY - JOUR A1 - Biener, Ernst A1 - Sasse, T. A1 - Arnold, J. A1 - Woltering, S. T1 - New treatment of harbour sludge in Bremen and Bremerhaven / E. Biener ; T. Sasse ; J. Arnold ; S. Woltering ; N. Binder JF - Characterisation and treatment of sediments : Antwerpen, Belgium, September 15 - 17, 1999 ; [preceded by 12th International Harbour Congress] ; proceedings / CATS 4. Ed.: G. De Schutter. Organized by: Technologisch Instituut, Koninklijke Vlaamse Ingenieursvereniging Y1 - 1999 SN - 9076019118 N1 - CATS <4, 1999, Anvers> SP - 115 EP - 122 PB - Technolog. Inst. CY - Anvers ER - TY - JOUR A1 - Biener, Ernst A1 - Sasse, T. A1 - Bökers, H. T1 - Preliminary or final capping of sanitary landfills? : Technical and economical aspects JF - Sardinia 99 : proceedings / Seventh International Waste Management and Landfill Symposium, [4 - 8 October 1999, S. Margherita di Pula, Cagliari, Sardinia, Italy]. Ed.: Thomas H. Christensen. - Bd. 3 : Barriers, waste mechanics and landfill design Y1 - 1999 N1 - International Waste Management and Landfill Symposium <7, 1999, Cagliari> SP - 287 EP - 294 PB - CISA, Environmental Sanitary Engineering Centre CY - Cagliari ER - TY - JOUR A1 - Biener, Ernst A1 - Sasse, T. A1 - Konertz, K. T1 - Preparation of mineral sealing materials for landfills by different processing technologies / Sasse, T. ; Biener, E. ; Konertz, K. JF - Sardinia 93 : Fourth International Landfill Symposium "Barrier systems, environmental aspects, upgrading and remediation, siting, monofills, effects of waste pretreatment, landfilling in developing countries" ; 11 - 15 October 1993, S. Margherita di Pula (Cagliari), Sardinia, Italy ; proceedings / coord. by Thomas H. Christensen ... - Bd. 1 Y1 - 1993 N1 - International Landfill Symposium <4, 1993, Santa Margherita, Pula> SP - 275 EP - 283 PB - CISA, Environmental Sanitary Engineering Centre CY - Cagliari ER - TY - JOUR A1 - Biener, Ernst A1 - Sasse, T. A1 - Wernhoff, T. T1 - Using harbour dredged material for combination sealing of the former Bockhorner Weg disposal site in Bremen, Germany JF - Proceedings of the International Harbour Congress. 13 (2003) Y1 - 2003 N1 - International Harbour Congress <13, 2003, Antwerpen> SP - 101 EP - 109 ER - TY - JOUR A1 - Biener, Ernst A1 - Wemhoff, T. A1 - Bethke, H. T1 - Stability and settlement problems based on the example of the Blockland landfill in Bremen JF - Sardinia 95 : Fifth International Landfill Symposium ; (2 - 6 October 1995, S. Margheritadi Pula - Cagliari, Sardinia, Italy) ; proceedings / coord.: Thomas H. Christensen ... - Bd. 2 : Siting, lining, drainage & landfill mechanics Y1 - 1995 N1 - International Landfill Symposium <5, 1995, Santa Margherita, Pula> SP - 843 EP - 853 PB - CISA, Environmental Sanitary Engineering Centre CY - Cagliari ER - TY - JOUR A1 - Bindal, Gaurav A1 - Sharma, Sparsh A1 - Janser, Frank A1 - Neu, Eugen T1 - Detailed analysis of variables affecting wing kinematics of bat flight JF - SAE International Journal of Aerospace Y1 - 2013 U6 - http://dx.doi.org/10.4271/2013-01-9003 SN - 1946-3901 VL - 6 IS - 2 SP - 811 EP - 818 ER - TY - CHAP A1 - Bindzus, Manuel A1 - Bragard, Michael T1 - Motivating Intuitive Understanding of the Switched Reluctance Machine in the Education of Undergraduate Students T2 - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) Y1 - 2018 SN - 978-1-5386-6903-7 U6 - http://dx.doi.org/10.1109/RTUCON.2018.8659870 SP - 1 EP - 6 ER - TY - CHAP A1 - Birgel, Stefan A1 - Leschinger, Tim A1 - Wegmann, Kilian A1 - Staat, Manfred ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Calculation of muscle forces and joint reaction loads in shoulder area via an OpenSim based computer calculation T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 N1 - In der Druckausgabe des Abstractbandes ist dieser Beitrag lose als Erratum beigefügt. SP - 116 EP - 117 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Birgel, Stefan A1 - Leschinger, Tim A1 - Wegmann, Kilian A1 - Staat, Manfred T1 - Calculation of muscle forces and joint reaction loads in the shoulder area via an OpenSim based computer model JF - tm - Technisches Messen N2 - Using the OpenSim software and verified anatomical data, a computer model for the calculation of biomechanical parameters is developed and used to determine the effect of a reattachment of the Supraspinatus muscle with a medial displacement of the muscle attachment point, which may be necessary for a rupture of the supraspinatus tendon. The results include the influence of the operation on basic biomechanical parameters such as the lever arm, as well as the calculated the muscle activations for the supraspinatus and deltoid. In addition, the influence on joint stability is examined by an analysis of the joint reaction force. The study provides a detailed description of the used model, as well as medical findings to a reattachment of the supraspinatus. Mit der Software OpenSim und überprüften anatomischen Daten wird ein Computermodell zur Berechnung von biomechanischen Parametern entwickelt und genutzt, um den Effekt einer Refixierung des Supraspinatusmuskels mit einer medialen Verschiebung des Muskelansatzpunktes zu ermitteln, wie sie unter anderem nach einem Riss der Supraspinatussehne notwendig sein kann. Die Ergebnisse umfassen hierbei den Einfluss der Operation auf grundlegende biomechanische Parameter wie den Hebelarm sowie die berechneten Muskelaktivierungen für den Supraspinatus und Deltoideus. Zusätzlich wird der Einfluss auf die Gelenkstabilität betrachtet und durch eine Analyse der Gelenkreaktionskraft untersucht. Die Studie bietet eine detaillierte Beschreibung des genutzten Modells, sowie medizinische Erkenntnisse zu einer Refixierung des Supraspinatus. Y1 - 2018 U6 - http://dx.doi.org/10.1515/teme-2017-0114 SN - 2196-7113 VL - 85 IS - 5 SP - 321 EP - 330 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Birkl, Josef A1 - Diendorfer, Gerhard A1 - Kern, Alexander A1 - Thern, Stephan T1 - Extremely high lightning peak currents T2 - 34th International Conference on Ligntning Protection, 02-07 September 2018 Y1 - 2018 SN - 978-1-5386-6635-7 ER - TY - JOUR A1 - Biselli, Manfred A1 - Born, C. A1 - Thömmes, J. A1 - Wandrey, C. T1 - An approach to integrated antibody production: Coupling of fluidized bed cultivation and fluidized bed adsorption / Born, C. ; Thömmes, J. ; Biselli, M. ; Wandrey, C. ; Kula, M.-R. JF - Bioprocess Engineering. 15 (1996), H. 1 Y1 - 1996 SN - 1615-7591 SP - 21 EP - 29 ER - TY - JOUR A1 - Biselli, Manfred A1 - Born, C. A1 - Wandrey, C. T1 - Oxygen transfer from the gasphase to the immobilized cells in membrane aerated fluidized beds / Born, C. ; Biselli, M. ; Wandrey, C. JF - Animal cell technology : basic & applied aspects : proceedings of the Eighth Annual Meeting of the Japanese Association for Animal Cell Technology, Iizuka, Fukuoka, Japan, November 6-10, 1995 / edited by K. Funatsu, Y. Shirai, and T. Matsushita Y1 - 1995 SN - 0-7923-4486-3 N1 - Japanese Association for Animal Cell Technology. ; Meeting ; <8 ; 1995 : ; Iizuka-shi, Japan> SP - 83 EP - 87 PB - Kluwer Acad. Press CY - Boston ER - TY - JOUR A1 - Biselli, Manfred A1 - Born, C. A1 - Wandrey, C. T1 - Production of monoclonal antibodies in a pilot scale fluidized bed bioreactor / Born, C.; Biselli, M.; Wandrey, C. JF - Animal cell technology : developments towards the 21st century / edited by E. C. Beuvery Y1 - 1995 SN - 0-7923-3736-0 N1 - Meeting "Animal Cell Technology, Developments towards the 21st Century" ; <1994.09.12-16 : ; Veldhoven> SP - 515 EP - 519 PB - Kluwer Acad. Press CY - Dordrecht ER - TY - JOUR A1 - Biselli, Manfred A1 - Hambach, B. A1 - Runstadler, P. W. A1 - Wandrey, Christian T1 - Development of a reactor-integrated aeration system for cultivation of animal cells in fluidized beds / Hambach, B. ; Biselli, M. ; Runstadler, P.W. ; Wandrey, C. JF - Animal cell technology : developments, processes, and products ; ESACT, European Society for Animal Cell Technology, the 11th meeting / Ed. R. E. Spier Y1 - 1992 SN - 0750604212 SP - 381 EP - 385 PB - Butterworth-Heinemann CY - Oxford ER - TY - JOUR A1 - Biselli, Manfred A1 - Hilbert, U. A1 - Jelinek, N. A1 - Schmidt, S. T1 - Bioprocess development for the cultivation of human T-lymphocytes / Hilbert, U. ; Jelinek, N. Schmidt, S. ; Biselli, M. JF - Engineering in Life Sciences. 1 (2001) Y1 - 2001 SN - 1618-0240 SP - 20 EP - 23 ER - TY - JOUR A1 - Biselli, Manfred A1 - Hilbert, U. A1 - Noll, T. T1 - Cultivation of Human HCMV Specific Lymphocytes – An Example for Adoptive Immunotherapy / Hilbert, U. ; Biselli, M. ; Noll, T. JF - Animal cell technology : from target to market ; Tylösand, Sweden, June 10 - 14, 2001 / ed. by E. Lindner-Olsson ... Y1 - 2001 SN - 1-4020-0264-5 N1 - Proceedings of the ... ESACT meeting ; 17 SP - 558 EP - 561 PB - Kluwer CY - Dordrecht ER - TY - JOUR A1 - Biselli, Manfred A1 - Jelinek, N. A1 - Schmidt, S. A1 - Hilbert, U. T1 - Novel bioreactors for the ex vivo cultivation of hematopoietic cells / Jelinek, N. ; Schmidt, S. ; Hilbert, U. ; Thoma, S. ; Biselli, M. ; Wandrey, C. JF - Engineering in Life Sciences. 2 (2002), H. 1 Y1 - 2002 SN - 1618-0240 SP - 15 EP - 18 ER - TY - JOUR A1 - Biselli, Manfred A1 - Klyushnichenko, Vadim A1 - Rodenbrock, Anja A1 - Thömmes, Jörg T1 - Analysis of Hybridoma Cell Culture Processes by SDS-Gel Capillary Electrophoresis and matrix-assisted laser desorption ionization–time-of-flight MS / Vadim Klyushnichenko, Anja Rodenbrock, Jörg Thömmes, Maria-Regina Kula, Holger Heine, Manfred Biselli JF - Biotechnology and Applied Biochemistry. 27 (1998), H. 3 Y1 - 1998 SN - 0885-4513 SP - 181 EP - 188 ER - TY - JOUR A1 - Biselli, Manfred A1 - Kragl, U. A1 - Wandrey, C. T1 - Reaction Engineering for Enzyme-Catalyzed Biotransformations JF - Enzyme catalysis in organic synthesis : a comprehensive handbook. Bd. 1. - 2., completely rev. and enl. ed. / ed. by Karlheinz Drauz. Y1 - 2002 SN - 3-527-29949-1 N1 - erschienen: Vol. 1-3 SP - 185 EP - 257 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Biselli, Manfred A1 - Kragl, U. A1 - Wandrey, C. T1 - Reaction Engineering for Enzyme-Catalyzed Biotransformations JF - Enzyme catalysis in organic synthesis : a comprehensive handbook. Bd. 1. / ed. by Karlheinz Drauz. Y1 - 1995 SN - 3-527-28479-6 N1 - erschienen: Vol. 1-2 SP - 89 EP - 155 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Biselli, Manfred A1 - Lüllau, E. A1 - Dreisbach, C. A1 - Grogg, A. T1 - Immobilization of animal cells on chemically modified siran carrier / Lüllau, E. ; Dreisbach, C. ; Grogg, A. ; Biselli, M. ; Wandrey, C. JF - Animal cell technology : developments, processes, and products ; ESACT, European Society for Animal Cell Technology, the 11th meeting / Ed. R. E. Spier Y1 - 1992 SN - 0750604212 SP - 469 EP - 475 PB - Butterworth-Heinemann CY - Oxford ER - TY - JOUR A1 - Biselli, Manfred A1 - Lüllau, E. A1 - Wandrey, Christian T1 - Growth and metabolism of CHO-cells in porous glass carriers / Lüllau, E. ; Biselli, M. ; Wandrey, C. JF - Animal cell technology : products of today, prospects for tomorrow ; ESACT, European Society for Animal Cell Technology, the 12th meeting / Ed. R. E. Spier Y1 - 1994 SN - 0750618450 N1 - Meeting / European Society for Animal Cell Technology ; 12 SP - 252 EP - 255 PB - Butterworth-Heinemann CY - Oxford ER - TY - JOUR A1 - Biselli, Manfred A1 - Meissner, Petra A1 - Schröder, Bernd A1 - Herfurth, Cornelia T1 - Development of a fixed bed bioreactor for the expansion of human hematopoietic progenitor cells / Meissner, Petra ; Schröder, Bernd ; Herfurth, Cornelia ; Biselli, Manfred JF - Cytotechnology. 30 (1999), H. 1 Y1 - 1999 SN - 0920-9069 SP - 227 EP - 234 ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, T. T1 - Dielectric spectroscopy in the cultivation of suspended and immobilized hybridoma cells / Noll, T.; Biselli, M. JF - Journal of Biotechnology. 63 (1998), H. 3 Y1 - 1998 SN - 0168-1656 SP - 187 EP - 198 ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, T. A1 - Wandrey, C. T1 - On-line biomass monitoring of immobilized hybridoma cells by dielectrical measurements / Noll, T. ; Biselli, M. ; Wandrey, C. JF - Animal cell technology : from vaccines to genetic medicine ; [Vilamoura, Portugal, May 1996] / ed. by Manuel J. T. Carrondo Y1 - 1997 SN - 0-7923-4321-2 SP - 289 EP - 294 PB - Kluwer CY - Dordrecht ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, Thomas A1 - Eisenkrätzer, Detlef A1 - Kiesewetter, André T1 - Improved product formation in high density Chinese hamster ovary cell cultures transfected at confluency / Thomas Noll, Detlef Eisenkrätzer, André Kiesewetter, André Dinter, Steffen Zeng, Christian Wandrey, Manfred Biselli und Eric G. Berger JF - Biotechnology Letters. 24 (2002), H. 11 Y1 - 2002 SN - 0141-5492 SP - 861 EP - 866 ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, Thomas A1 - Jelinek, Nanni A1 - Schmidt, Sebastian T1 - Cultivation of Hematopoietic Stem and Progenitor Cells: biochemical Engineering Aspects / Thomas Noll, Nanni Jelinek, Sebastian Schmidt, Manfred Biselli und Christian Wandrey JF - Tools and Applications of Biochemical Engineering Science Y1 - 2002 SN - 3-540-42250-1 N1 - Advances in Biochemical Engineering/Biotechnology. 74 SP - 111 EP - 128 PB - Springer CY - Berlin ER - TY - JOUR A1 - Biselli, Manfred A1 - Noll, Thomas A1 - Mühlsiepen, Heinz A1 - Engels, Ralf T1 - A cell-culture reactor for the on-line evaluation of radiopharmaceuticals : evaluation of the lumped constant of FDG in human glioma cells / Noll, Thomas ; Mühlensiepen, Heinz ; Engels, Ralf ; Hamacher, Kurt ; Papaspyrou, Manfred ; Langen, Karl-Josef ; Bi JF - Journal of Nuclear Medicine. 41 (2000), H. 3 Y1 - 2000 SN - 0022-3123 SP - 556 EP - 564 ER - TY - JOUR A1 - Biselli, Manfred A1 - Rechmann, Hanrik A1 - Friedrich, Andrea A1 - Forouzan, Dara T1 - Characterization of photosynthetically active duckweed ( Wolffia australiana ) in vitro culture by Respiration Activity Monitoring System (RAMOS) / Henrik Rechmann, Andrea Friedrich, Dara Forouzan, Stefan Barth, Heide Schnabl, Manfred Biselli und Robert B JF - Biotechnology Letters. 29 (2007), H. 6 Y1 - 2007 SN - 0141-5492 SP - 971 EP - 977 ER - TY - JOUR A1 - Biselli, Manfred A1 - Rolef, G. A1 - Dunker, R. A1 - Wandrey, Christian T1 - Optimization of antibody production in a fluidized bed bioreactor / Rolef, G. ; Biselli, M. ; Dunker, R. ; Wandrey, C. JF - Animal cell technology : products of today, prospects for tomorrow ; ESACT, European Society for Animal Cell Technology, the 12th meeting / Ed. R. E. Spier Y1 - 1994 SN - 0750618450 N1 - Meeting / European Society for Animal Cell Technology ; 12 SP - 481 EP - 484 PB - Butterworth-Heinemann CY - Oxford ER - TY - JOUR A1 - Biselli, Manfred A1 - Schmid, Georg A1 - Wandrey, Christian T1 - Preparation of cellodextrins and isolation of oligomeric side components and their characterization / Schmid, Georg ; Biselli, Manfred ; Wandrey, Christian JF - Analytical Biochemistry. 175 (1988) Y1 - 1988 SN - 0003-2697 SP - 573 EP - 583 ER - TY - JOUR A1 - Biselli, Manfred A1 - Schmidt, S. A1 - Büchs, J. A1 - Born, C. T1 - A new correlation for the wall-to-fluid mass transfer in liquid-sol fluidized beds / Schmidt, S. ; Büchs, J. ; Born, C. ; Biselli, M. JF - Chemical Engineering Science. 54 (1999), H. 6 Y1 - 1999 SN - 0009-2509 SP - 829 EP - 839 ER - TY - JOUR A1 - Biselli, Manfred A1 - Schröder, B. A1 - Herfurth, C. A1 - Meißner, P. T1 - Differentiation of bone marrow cells immobilized on microcarriers in a fluidized bed reactor / Schröder, B. ; Herfurth, C. ; Meißner, P. ; Biselli, M. ; Link, H. ; Wandrey, C. JF - Animal cell technology : from vaccines to genetic medicine ; [Vilamoura, Portugal, May 1996] / ed. by Manuel J. T. Carrondo Y1 - 1997 SN - 0-7923-4321-2 SP - 589 EP - 593 PB - Kluwer CY - Dordrecht ER - TY - JOUR A1 - Biselli, Manfred A1 - Schröder, B. A1 - Herfurth, C. A1 - Schmoll, H.-J. T1 - Cocultivation of hematopoietic cells in a fluidized bed reactor / Schröder, B. ; Herfurth, C. ; Biselli, M. ; Schmoll, H.-J. ; Link, H. ; Ebell, W. ; Wandrey, C. JF - Animal cell technology : basic & applied aspects : proceedings of the Eighth Annual Meeting of the Japanese Association for Animal Cell Technology, Iizuka, Fukuoka, Japan, November 6-10, 1995 / edited by K. Funatsu, Y. Shirai, and T. Matsushita Y1 - 1997 SN - 0-7923-4486-3 N1 - Japanese Association for Animal Cell Technology. ; Meeting ; <8 ; 1995 : ; Iizuka-shi, Japan> SP - 137 EP - 141 PB - Kluwer Acad. Press CY - Boston ER - TY - JOUR A1 - Biselli, Manfred A1 - Thömmes, J. A1 - Born, C. A1 - Wandrey, C. T1 - Purification of monoclonal antibodies by fluidized bed adsorption / Thömmes, J. ; Born, C. Biselli, M. ; Wandrey, C. ; Kula, M.-R. JF - Animal cell technology : developments towards the 21st century / edited by E. C. Beuvery Y1 - 1995 SN - 0-7923-3736-0 N1 - Meeting "Animal Cell Technology, Developments towards the 21st Century" ; <1994.09.12-16 : ; Veldhoven> SP - 515 EP - 519 PB - Kluwer Acad. Press CY - Dordrecht ER - TY - JOUR A1 - Biselli, Manfred A1 - Thömmes, J. A1 - Garske, U. A1 - Wandrey, Christian T1 - Integrated detoxification: Reduction of ammonium concentration by dialysis with cation exchange membranes / Thömmes, J. ; Garske, U. ; Biselli, M. ; Wandrey, C. JF - Animal cell technology : developments, processes, and products ; ESACT, European Society for Animal Cell Technology, the 11th meeting / Ed. R. E. Spier Y1 - 1992 SN - 0750604212 SP - 171 EP - 175 PB - Butterworth-Heinemann CY - Oxford ER - TY - JOUR A1 - Biselli, Manfred A1 - Thömmes, J. A1 - Gätgens, J. A1 - Runstadler, P. W. T1 - The influence of dissolved oxygen tension on the metabolic activity of an immobilized hybridoma population / Thömmes, J. ; Gätgens, J. ; Biselli, M. ; Runstadler, P.W. ; Wandrey, C. JF - Cytotechnology . 13 (1993), H. 1 Y1 - 1993 SN - 0920-9069 SP - 29 EP - 39 ER - TY - JOUR A1 - Biselli, Manfred A1 - Thömmes, J. A1 - Kula, M.-R. A1 - Wandrey, Christian T1 - Batch kinetic data of hybridoma growth and productivity as a basis for the simulation of antibody production in various culture systems / Thömmes, J. ; Biselli, M. ; Kula, M.-R. ; Wandrey, C. JF - Animal cell technology : products of today, prospects for tomorrow ; ESACT, European Society for Animal Cell Technology, the 12th meeting / Ed. R. E. Spier Y1 - 1994 SN - 0750618450 N1 - Meeting / European Society for Animal Cell Technology ; 12 SP - 513 EP - 517 PB - Butterworth-Heinemann CY - Oxford ER - TY - JOUR A1 - Biselli, Manfred A1 - Van der Pol, Jens J. A1 - De Gooijer, Cornelis D. A1 - Wandrey, Christian T1 - Automation of selective assays for on-line bioprocess monitoring by flow-injection analysis / van der Pol, Jens J. ; de Gooijer, Cornelis D. ; Biselli, Manfred ; Wandrey, Christian ; Tramper, Johannes JF - Trends in Biotechnology. 14 (1996), H. 12 Y1 - 1996 SN - 0167-7799 SP - 471 EP - 477 ER - TY - JOUR A1 - Biselli, Manfred A1 - Van der Pol, Jens J. A1 - Joksch, B. A1 - Eberhardt, R. T1 - Development of an enzymatic multichannel flow injection analysis system for monitoring mammalian cell fermentations / Van der Pol, J.J.; Joksch, B.; Eberhardt, R.; Biselli, M.; Wandrey, C., Tramper, J. JF - Biosensors : fundamentals, technologies and applications ; contributions to the BMFT status seminar with international participation May, 12 to 14, 1991, Internationales Bildungs-Centrum Bogensee/Brandenburg, Germany / org. by ZIM-Zentralinstitut für Molekularbiologie, Berlin-Buch and GBF, Braunschweig. Ed. by F. Scheller Y1 - 1992 SN - 3527284370 N1 - GBF Monographs ; 17 SP - 349 EP - 352 PB - VCH CY - Weinheim ER - TY - JOUR A1 - Biselli, Manfred A1 - Van der Pol, Jens J. A1 - Joksch, B. A1 - Spohn, U. T1 - On-line monitoring and control of glucose, glutamine, lactate and ammonium during a high-cell-density cultivation of hybridoma cells / van der Pol, Jens J. ; Joksch, B. ; Spohn, U. ; Biselli, M. ; Wandrey, C. JF - Proceedings of the sixth international meeting of the Japanese Association for Animal Cell Technology [JAACT 93]: Nagoya, Japan, November 9 - 12, 1993 / ed. by T. Kobayashi Y1 - 1994 SN - 0-7923-3156-7 N1 - International meeting of the Japanese Association for Animal Cell Technology, JAACT 93 ; (6 : ; 1993.11.09-12 : ; Nagoya, Japan) ; Animal cell technology, basic and applied aspects ; 6 SP - 167 EP - 170 PB - Springer Netherland CY - Berlin ER - TY - JOUR A1 - Biselli, Manfred A1 - Van der Pol, Jens J. A1 - Joksch, Burkhard A1 - Galgens, Jochem T1 - On-line control of an immobilized hybridoma culture with multi-channel flow injektion analysis / Jens J. van der Pol, Burkhard Joksch, Jochem Galgens, Manfred Biselli, Cornelis D. de Gooijer, Johannes Tramper and Christian Wandrey JF - Journal of Biotechnology. 43 (1995), H. 3 Y1 - 1995 SN - 0168-1656 N1 - 3. Autor vermutlich: Jochen Gätgens SP - 229 EP - 242 ER - TY - JOUR A1 - Biselli, Manfred A1 - Van der Pol, Jens J. A1 - Machnik, Marc A1 - Portela-Klein, Theresa T1 - On-line immunoanalysis of monoclonal antibodies during a continuous culture of hybridoma cells / Jens J. van der Pol, Marc Machnik, Manfred Biselli, Theresa Portela-Klein, Cornelis D. de Gooijer, Johannes Tramper und Christian Wandrey JF - Cytotechnology. 24 (1997), H. 1 Y1 - 1997 SN - 0920-9069 SP - 19 EP - 30 ER - TY - JOUR A1 - Biselli, Manfred A1 - Van der Pol, Jens J. A1 - Spohn, Uwe A1 - Eberhardt, Rolf T1 - On-line monitoring of an animal cell culture with multi-channel flow injection analysis / van der Pol, Jens J.; Spohn, Uwe ; Eberhardt, Rolf ; Gätgens, Jochen ; Biselli, Manfred ; Wandrey, Christian ; Tramper, Johannes JF - Journal of Biotechnology. 37 (1994), H. 3 Y1 - 1994 SN - 0168-1656 SP - 253 EP - 264 ER - TY - JOUR A1 - Biselli, Manfred A1 - Wandrey, Christian T1 - Reaction Mechanism of an Endoglucanase of Trichoderma Reesei QM 9414 using Cellodextrins as Substrate JF - Technology of biological processes, safety in biotechnology, applied genetic engineering : lectures held at the 5th DECHEMA Annual Meeting of Biotechnologists, May 12 - 13, 1987, [Frankfurt, Main] / [hrsg. von Dieter Behrens ...] Y1 - 1988 N1 - Jahrestagung der Biotechnologen ; <5, 1987, Frankfurt, Main> ; DECHEMA Biotechnology Conferences series ; 1 SP - 425 EP - 429 PB - VCH CY - Weinheim ER - TY - JOUR A1 - Biselli, Manfred A1 - Zeng, Steffen A1 - Dinter, Andre A1 - Eisenkrätzer, Detlef T1 - Pilot Scale Expression and Purification of Soluble Protein A Tagged β1,6N-Acetylglucosaminyltransferase in CHO Cells / Zeng, Steffen ; Dinter, Andre ; Eisenkrätzer, Detlef ; Biselli, Manfred ; Wandrey, Christian ; Berger, Eric G. JF - Biochemical and Biophysical Research Communications. 237 (1997), H. 3 Y1 - 1997 SN - 0006-291X SP - 653 EP - 658 ER - TY - CHAP A1 - Bitz, Andreas A1 - Alaydrus, M. A1 - Streckert, J. A1 - Hansen, V. T1 - Combination of the hybrid/sup [2]/-method and the FDTD-method for solution of boundary value problems with electrically large and high-resolution bodies T2 - IEEE Antennas and Propagation Society International Symposium (IEEE Cat. No.02CH37313) 2002 : San Antonio, TX, USA, 16-21 June Y1 - 2002 SN - 0-7803-7330-8 U6 - http://dx.doi.org/10.1109/APS.2002.1018209 SP - 278 EP - 281 PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Bitz, Andreas A1 - Alaydrus, M. A1 - Streckert, J. A1 - Hansen, V.W. T1 - Absorption rates inside human body due to radiated electro-magnetic fields of multi-band base station antennas. Boundary value problems with electrically large and high-resolution bodies T2 - 24th BEMS Annual Meeting, Quebec City, Quebec, Canada, 23 - 27 June 2002 Y1 - 2002 SP - 40 EP - 41 PB - Bioelectromagnetics Society CY - Frederick, MD ER - TY - CHAP A1 - Bitz, Andreas A1 - Alaydrus, M. A1 - Streckert, J. A1 - Hansen, V.W. T1 - Base station antennas embedded in complex environments: rf exposure in controlled areas T2 - 23rd BEMS Annual Meeting, St. Paul, Minnesota, USA, 49-50, June 2001 Y1 - 2001 SP - 49 EP - 50 PB - Bioelectromagnetics Society CY - Frederick, MD ER - TY - CHAP A1 - Bitz, Andreas A1 - El Ouardi, A. A1 - Streckert, J. A1 - Hansen, V. T1 - Efficient calculation of human exposure in front of base station antennas by a combination of the FDTD and Hybrid(2)-method T2 - Proceedings of the 16th International Zurich Symposium on Electromagnetic Compatibility, Topical Meeting on Biomedical EMC, Zurich, Switzerland, February 2005 Y1 - 2005 SN - 3-9521199-9-7 SP - 115 EP - 118 PB - ETH Zentrum CY - Zürich ER - TY - JOUR A1 - Bitz, Andreas A1 - Felder, Jorg A1 - Wittig, Tilmann T1 - Designing MRI Coils with Aid of Simulation JF - Microwaves & RF Y1 - 2013 SN - 0745-2993 VL - 52 IS - 7 SP - 56 PB - Penton CY - Cleveland, Ohio ER - TY - CHAP A1 - Bitz, Andreas A1 - Klomp, D.W. A1 - Ladd, M.E. T1 - Experimental and numerical determination of SAR and temperature distribution of a human endorectal coil for MR imaging of the prostate at 7T (903.) T2 - 16th annual ISMRM scientific meeting and exhibition 2008 : Toronto, Ontario, Canada, 3 - 9 May 2008 Y1 - 2009 SN - 978-1-61567-196-0 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Bitz, Andreas A1 - Kobus, Thiele A1 - Scheenen, Tom W. J. A1 - Ladd, Mark E. T1 - RF Safety of the Combination of a 31P Tx/Rx Endorectal Coil & a 1H Tx/Rx Body Array for 31P MRSI of the Prostate at 7T (311.) T2 - 20th Annual ISMRM scientific meeting and exhibition 2012 : Melbourne, Australia, 5 - 11 May 2012 Y1 - 2013 SN - 978-1-62276-943-8 SN - 1545-4428 IS - Volume 1 SP - 311 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Bitz, Andreas A1 - Kraff, O. A1 - Orzada, S. A1 - Maderwald, S. A1 - Brote, I. A1 - Johst, S. A1 - Ladd, E. T1 - Assessment of RF Safety of Transmit Coils at 7 Tesla by Experimental and Numerical Procedures (490.) T2 - 19th annual ISMRM scientific meeting and exhibition 2011 : Montreal, Quebec, Canada, 7 - 13 May 2011 Y1 - 2012 SN - 978-1-61839-284-8 IS - Volume 1 SP - 475 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Bitz, Andreas A1 - Kraff, O. A1 - Orzada, S. A1 - Maderwald, S. A1 - Brote, I. A1 - Ladd, M. T1 - Experimental and Numerical Assessment of RF Safety of Transmit Coils at 7 Tesla T2 - ISMRM workshop on MR safety 2010 : RF heating of the human in MRI : workshop series. The Washington County Historic Courthouse, Stillwater, Minnesota, USA, 15 - 17 October 2010 Y1 - 2010 SN - 978-1-62276-088-6 SP - 195 ER - TY - CHAP A1 - Bitz, Andreas A1 - Streckert, J. A1 - Hansen, V.W. A1 - Buschmann, J. T1 - RF exposure of non restrained animals in an overmoded radial waveguide T2 - 22nd BEMS Annual Meeting, Munich, Germany, 2000 Y1 - 2000 SP - 63 PB - Bioelectromagnetics Society CY - Frederick, MD ER - TY - CHAP A1 - Bitz, Andreas A1 - Streckert, J. A1 - Hansen, V.W. A1 - Stogbauer, F. ED - Hietanen, Maila ED - Jokela, Kari ED - Juutilainen, Jukka ED - Työterveyslaitos, T1 - Shielded RF-exposure system with an integrated LF-measuring system for in vitro experiments with cell-layers T2 - Proceedings of the Ebea 2001 : 5th International Congress of the European Bioelectromagnetics Association (Ebea) ; 6-8 September 2001, Marina Congress Center, Helsinki, Finland Y1 - 2001 SN - 9789518024401 SP - 67 EP - 68 PB - Finnish Institute of Occupational Health CY - Helsinki ER - TY - CHAP A1 - Bitz, Andreas A1 - Streckert, J.R. A1 - Hansen, V.W. A1 - Lerchl, A. ED - Danesy, Dorothea T1 - Freely moving or restrained animals in bioelec-tromagnetic experiments - pros and cons T2 - AP 2000 : Millennium Conference on Antennas & Propagation, Davos, Switzerland, 9 - 14 April 2000 Y1 - 2000 IS - Band 1 SP - 489 PB - ESA Publications Division, ESTEC CY - Noordwijk ER - TY - JOUR A1 - Bitz, Andreas A1 - Zhou, Yi A1 - El Quardi, Abdessamad A1 - Streckert, Joachim T1 - Occupational Exposure at Mobile Communication Base Station Antenna Sites JF - Frequenz Y1 - 2009 U6 - http://dx.doi.org/10.1515/FREQ.2009.63.7-8.123 SN - 2191-6349 VL - 63 IS - 7-8 SP - 123 EP - 128 ER - TY - CHAP A1 - Blake, D. A1 - Moens, L. A1 - Hale, M.-J. A1 - Price, Henry A1 - Keaney, David W. A1 - Herrmann, Ulf ED - Steinfeld, Aldo T1 - New heat transfer and storage fluids for parabolic trough solar thermal electric plants T2 - Proceedings of the 11th SolarPACES International Symposium on Concentrated Solar Power and Chemical Energy Technologies : September 4 - 6, 2002, Zurich, Switzerland / Paul Scherrer Institut, PSI; ETH, Eidgenössische Technische Hochschule Zürich Y1 - 2002 SN - 3-9521409-3-7 SP - 63 EP - 66 PB - Paul Scherrer Inst. CY - Villingen ER - TY - CHAP A1 - Blaneck, Patrick Gustav A1 - Bornheim, Tobias A1 - Grieger, Niklas A1 - Bialonski, Stephan T1 - Automatic readability assessment of german sentences with transformer ensembles T2 - Proceedings of the GermEval 2022 Workshop on Text Complexity Assessment of German Text N2 - Reliable methods for automatic readability assessment have the potential to impact a variety of fields, ranging from machine translation to self-informed learning. Recently, large language models for the German language (such as GBERT and GPT-2-Wechsel) have become available, allowing to develop Deep Learning based approaches that promise to further improve automatic readability assessment. In this contribution, we studied the ability of ensembles of fine-tuned GBERT and GPT-2-Wechsel models to reliably predict the readability of German sentences. We combined these models with linguistic features and investigated the dependence of prediction performance on ensemble size and composition. Mixed ensembles of GBERT and GPT-2-Wechsel performed better than ensembles of the same size consisting of only GBERT or GPT-2-Wechsel models. Our models were evaluated in the GermEval 2022 Shared Task on Text Complexity Assessment on data of German sentences. On out-of-sample data, our best ensemble achieved a root mean squared error of 0:435. Y1 - 2022 U6 - http://dx.doi.org/10.48550/arXiv.2209.04299 N1 - Proceedings of the 18th Conference on Natural Language Processing/Konferenz zur Verarbeitung natürlicher Sprache (KONVENS 2022) 12-15 September, 2022 University of Potsdam Potsdam, Germany SP - 57 EP - 62 PB - Association for Computational Linguistics CY - Potsdam ER - TY - CHAP A1 - Blanke, Tobias A1 - Dring, Bernd A1 - Vontein, Marius A1 - Kuhnhenne, Markus T1 - Climate Change Mitigation Potentials of Vertical Building Integrated Photovoltaic T2 - 8th International Workshop on Integration of Solar Power into Power Systems : 16-17 October 2018, Stockholm, Sweden Y1 - 2018 SP - 1 EP - 7 ER - TY - JOUR A1 - Blanke, Tobias A1 - Hagenkamp, Markus A1 - Döring, Bernd A1 - Göttsche, Joachim A1 - Reger, Vitali A1 - Kuhnhenne, Markus T1 - Net-exergetic, hydraulic and thermal optimization of coaxial heat exchangers using fixed flow conditions instead of fixed flow rates JF - Geothermal Energy N2 - Previous studies optimized the dimensions of coaxial heat exchangers using constant mass fow rates as a boundary condition. They show a thermal optimal circular ring width of nearly zero. Hydraulically optimal is an inner to outer pipe radius ratio of 0.65 for turbulent and 0.68 for laminar fow types. In contrast, in this study, fow conditions in the circular ring are kept constant (a set of fxed Reynolds numbers) during optimization. This approach ensures fxed fow conditions and prevents inappropriately high or low mass fow rates. The optimization is carried out for three objectives: Maximum energy gain, minimum hydraulic efort and eventually optimum net-exergy balance. The optimization changes the inner pipe radius and mass fow rate but not the Reynolds number of the circular ring. The thermal calculations base on Hellström’s borehole resistance and the hydraulic optimization on individually calculated linear loss of head coefcients. Increasing the inner pipe radius results in decreased hydraulic losses in the inner pipe but increased losses in the circular ring. The net-exergy diference is a key performance indicator and combines thermal and hydraulic calculations. It is the difference between thermal exergy fux and hydraulic efort. The Reynolds number in the circular ring is instead of the mass fow rate constant during all optimizations. The result from a thermal perspective is an optimal width of the circular ring of nearly zero. The hydraulically optimal inner pipe radius is 54% of the outer pipe radius for laminar fow and 60% for turbulent fow scenarios. Net-exergetic optimization shows a predominant infuence of hydraulic losses, especially for small temperature gains. The exact result depends on the earth’s thermal properties and the fow type. Conclusively, coaxial geothermal probes’ design should focus on the hydraulic optimum and take the thermal optimum as a secondary criterion due to the dominating hydraulics. Y1 - 2021 U6 - http://dx.doi.org/10.1186/s40517-021-00201-3 SN - 2195-9706 N1 - Corresponding author: Tobias Blanke VL - 9 IS - Article number: 19 PB - Springer CY - Berlin ER - TY - CHAP A1 - Blanke, Tobias A1 - Schmidt, Katharina S. A1 - Göttsche, Joachim A1 - Döring, Bernd A1 - Frisch, Jérôme A1 - van Treeck, Christoph ED - Weidlich, Anke ED - Neumann, Dirk ED - Gust, Gunther ED - Staudt, Philipp ED - Schäfer, Mirko T1 - Time series aggregation for energy system design: review and extension of modelling seasonal storages T2 - Energy Informatics N2 - Using optimization to design a renewable energy system has become a computationally demanding task as the high temporal fluctuations of demand and supply arise within the considered time series. The aggregation of typical operation periods has become a popular method to reduce effort. These operation periods are modelled independently and cannot interact in most cases. Consequently, seasonal storage is not reproducible. This inability can lead to a significant error, especially for energy systems with a high share of fluctuating renewable energy. The previous paper, “Time series aggregation for energy system design: Modeling seasonal storage”, has developed a seasonal storage model to address this issue. Simultaneously, the paper “Optimal design of multi-energy systems with seasonal storage” has developed a different approach. This paper aims to review these models and extend the first model. The extension is a mathematical reformulation to decrease the number of variables and constraints. Furthermore, it aims to reduce the calculation time while achieving the same results. KW - Energy system KW - Renewable energy KW - Mixed integer linear programming (MILP) KW - Typical periods KW - Time-series aggregation Y1 - 2022 U6 - http://dx.doi.org/10.1186/s42162-022-00208-5 SN - 2520-8942 N1 - Proceedings of the 11th DACH+ Conference on Energy Informatics, 15-16 September 2022, Freiburg, Germany. VL - 5 IS - 1, Article number: 17 SP - 1 EP - 14 PB - Springer Nature ER - TY - JOUR A1 - Bleilevens, Christian A1 - Hill, Aileen A1 - Grzanna, Tim A1 - Fechter, Tamara A1 - Bohnen, Melanie A1 - Weber, Hans-Joachim A1 - Beckers, Christian A1 - Borosch, Sebastian A1 - Zayat, Rashad A1 - Benstoem, Carin A1 - Rossaint, Rolf A1 - Goetzenich, Andreas T1 - In vitro head-to-head comparison of anticoagulation properties of two heparin brands in a human blood miniature mock loop JF - Interactive cardiovascular and thoracic surgery Y1 - 2019 U6 - http://dx.doi.org/10.1093/icvts/ivy206 SN - 1569-9285 VL - 28 IS - 1 SP - 120 EP - 127 ER - TY - JOUR A1 - Block, Franziska A1 - May, Alexander A1 - Wetzel, Katharina A1 - Adels, Klaudia A1 - Elbers, Gereon A1 - Schulze, Margit A1 - Monakhova, Yulia T1 - What is the best spectroscopic method for simultaneous analysis of organic acids and (poly)saccharides in biological matrices: Example of Aloe vera extracts? JF - Talanta Open N2 - Several species of (poly)saccharides and organic acids can be found often simultaneously in various biological matrices, e.g., fruits, plant materials, and biological fluids. The analysis of such matrices sometimes represents a challenging task. Using Aloe vera (A. vera) plant materials as an example, the performance of several spectro-scopic methods (80 MHz benchtop NMR, NIR, ATR-FTIR and UV–vis) for the simultaneous analysis of quality parameters of this plant material was compared. The determined parameters include (poly)saccharides such as aloverose, fructose and glucose as well as organic acids (malic, lactic, citric, isocitric, acetic, fumaric, benzoic and sorbic acids). 500 MHz NMR and high-performance liquid chromatography (HPLC) were used as the reference methods. UV–vis data can be used only for identification of added preservatives (benzoic and sorbic acids) and drying agent (maltodextrin) and semiquantitative analysis of malic acid. NIR and MIR spectroscopies combined with multivariate regression can deliver more informative overview of A. vera extracts being able to additionally quantify glucose, aloverose, citric, isocitric, malic, lactic acids and fructose. Low-field NMR measurements can be used for the quantification of aloverose, glucose, malic, lactic, acetic, and benzoic acids. The benchtop NMR method was successfully validated in terms of robustness, stability, precision, reproducibility and limit of detection (LOD) and quantification (LOQ), respectively. All spectroscopic techniques are useful for the screening of (poly)saccharides and organic acids in plant extracts and should be applied according to its availability as well as information and confidence required for the specific analytical goal. Benchtop NMR spectroscopy seems to be the most feasible solution for quality control of A. vera products. KW - Spectroscopy KW - (Poly)saccharides KW - Organic acids KW - Aloe vera KW - qNMR Y1 - 2023 U6 - http://dx.doi.org/10.1016/j.talo.2023.100220 SN - 2666-8319 VL - 7 IS - Art. No. 100220 SP - 1 EP - 9 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Blome, Hans-Joachim T1 - The scale of the universe: a unit of length JF - Comments on astrophysics. 17 (1994) Y1 - 1994 SN - 0146-2970 SP - 327 EP - 335 ER - TY - JOUR A1 - Blome, Hans-Joachim A1 - Chicone, Carmen A1 - Hehl, Friedrich W. A1 - Mashhoon, Bahram T1 - Nonlocal modification of Newtonian gravity JF - Physical Review D Y1 - 2010 SN - 0556-2821 N1 - 11 pages VL - 81 IS - 6 SP - 065020 ER -