TY - JOUR A1 - Seibler, Jost A1 - Küter-Luks, Birgit A1 - Kern, Heidrun A1 - Streu, Sandra A1 - Plum, Leona A1 - Maurer, Jan A1 - Kühn, Ralf A1 - Brüning, Jens C. A1 - Schwenk, Frieder T1 - Single copy shRNA configuration for ubiquitous gene knockdown in mice JF - Nucleic Acids Research Y1 - 2005 U6 - https://doi.org/10.1093/nar/gni065 SN - 1362-4962 VL - 33 IS - 7 SP - e67 ER - TY - JOUR A1 - Seibler, Jost A1 - Zevnik, Branko A1 - Küter-Luks, Birgit A1 - Andreas, Susanne A1 - Kern, Heidrun A1 - Hennek, Thomas A1 - Rode, Anja A1 - Heimann, Cornelia A1 - Faust, Nicole A1 - Kauselmann, Gunther A1 - Schoor, Michael A1 - Jaenisch, Rudolf A1 - Rajewsky, Klaus A1 - Kühn, Ralf A1 - Schwenk, Frieder T1 - Rapid generation of inducible mouse mutants JF - Nucleic Acids Research Y1 - 2003 U6 - https://doi.org/10.1093/nar/gng012 SN - 1362-4962 VL - 33 IS - 4 SP - e12 ER - TY - JOUR A1 - Goetze, Sandra A1 - Baer, Alexandra A1 - Winkelmann, Silke A1 - Nehlsen, Kristina A1 - Seibler, Jost A1 - Maass, Karin A1 - Bode, Jürgen T1 - Performance of genomic bordering elements at predefined genomic loci JF - Molecular and Cellular Biology Y1 - 2005 U6 - https://doi.org/10.1128/MCB.25.6.2260-2272.2005 SN - 1098-5549 VL - 25 IS - 6 SP - 2260 EP - 2272 ER - TY - CHAP A1 - Kümmell, Steffen A1 - Hillgärtner, Michael T1 - Inductive charging comfortable and nonvisible charging stations for urbanised areas T2 - E-Mobility in Europe : trends and good practice N2 - For a wide acceptance of E-Mobility, a well-developed charging infrastructure is needed. Conductive charging stations, which are today’s state of the art, are of limited suitability for urbanised areas, since they cause a significant diversification in townscape. Furthermore, they might be destroyed by vandalism. Besides for those urbanistic reasons, inductive charging stations are a much more comfortable alternative, especially in urbanised areas. The usage of conductive charging stations requires more or less bulky charging cables. The handling of those standardised charging cables, especially during poor weather conditions, might cause inconvenience, such as dirty clothing etc. Wireless charging does not require visible and vandalism vulnerable charge sticks. No wired connection between charging station and vehicle is needed, which enable the placement below the surface of parking spaces or other points of interest. Inductive charging seems to be the optimal alternative for E-Mobility, as a high power transfer can be realised with a manageable technical and financial effort. For a well-accepted and working public charging infrastructure in urbanised areas it is essential that the infrastructure fits the vehicles’ needs. Hence, a well-adjusted standardisation of the charging infrastructure is essential. This is carried out by several IEC (International Electrotechnical Commission) and national standardisation committees. To ensure an optimised technical solution for future’s inductive charging infrastructures, several field tests had been carried out and are planned in near future. KW - E-mobility KW - Inductive charging KW - Charging stations KW - Urban areas Y1 - 2015 SN - 978-3-319-13193-1 U6 - https://doi.org/10.1007/978-3-319-13194-8_16 SP - 297 EP - 309 PB - Springer CY - Cham [u.a.] ER - TY - JOUR A1 - Yoshinobu, Tatsuo A1 - Moritz, Werner A1 - Finger, Friedhelm A1 - Schöning, Michael Josef ED - Comini, Elisabetta T1 - Application of thin-film amorphous silicon to chemical imaging JF - Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A. Y1 - 2006 SN - 9781558998711 N1 - Materials Research Society symposia proceedings; v. 915 IS - Paper 0910-A-20-01 SP - 1 EP - 10 ER - TY - JOUR A1 - Takenaga, Shoko A1 - Schneider, Benno A1 - Erbay, E. A1 - Biselli, Manfred A1 - Schnitzler, Thomas A1 - Schöning, Michael Josef A1 - Wagner, Torsten T1 - Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process JF - Physica status solidi (a) N2 - A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation. Y1 - 2015 U6 - https://doi.org/10.1002/pssa.201532053 SN - 1862-6319 VL - 212 IS - 6 SP - 1347 EP - 1352 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Inagaki, Akiko A1 - Sleddens-Linkels, Esther A1 - Wassenaar, Evelyne A1 - Ooms, Marja A1 - Cappellen, Wiggert A. van A1 - Hoeijmakers, Jan H. J. A1 - Seibler, Jost A1 - Vogt, Thomas F. A1 - Shin, Myung K. A1 - Grootegoed, J. Anton A1 - Baarends, Willy M. T1 - Meiotic functions of RAD18 JF - Journal of Cell Science Y1 - 2011 U6 - https://doi.org/10.1242/jcs.081968 SN - 1477-9137 VL - 124 IS - 16 SP - 2837 EP - 2850 PB - Company of Biologists Limited CY - Cambridge ER - TY - JOUR A1 - Raab, Monika A1 - Kappel, Sven A1 - Krämer, Andrea A1 - Sanhaji, Mourad A1 - Matthess, Yves A1 - Kurunci-Csacsko, Elisabeth A1 - Calzada-Wack, Julia A1 - Rathkolb, Birgit A1 - Rosman, Jan A1 - Adler, Thure A1 - Busch, Dirk H. A1 - Esposito, Irene A1 - Fuchs, Helmut A1 - Gailus-Durner, Valérie A1 - Klingenspor, Martin A1 - Wolf, Eckhard A1 - Sänger, Nicole A1 - Prinz, Florian A1 - Hrabe de Angelis, Martin A1 - Seibler, Jost A1 - Yuan, Juping A1 - Bergmann, Martin A1 - Knecht, Rainald A1 - Kreft, Bertolt A1 - Strebhardt, Klaus T1 - Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells JF - Nature Communications Y1 - 2011 U6 - https://doi.org/10.1038/ncomms1395 SN - 2041-1723 VL - 2 IS - 395 SP - 1 EP - 11 PB - Nature CY - London ER - TY - JOUR A1 - Hasegawa, Maki A1 - Kapelyukh, Yury A1 - Tahara, Harunobu A1 - Seibler, Jost A1 - Rode, Anja A1 - Krueger, Sylvia A1 - Lee, Dongtao N. A1 - Wolf, C. Roland A1 - Scheer, Nico T1 - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line JF - Molecular Pharmacology Y1 - 2011 U6 - https://doi.org/10.1124/mol.111.071845 SN - 1521-0111 VL - 80 IS - 33 SP - 518 EP - 528 PB - ASPET CY - Bethesda, Md. ER - TY - JOUR A1 - Jordan, Sabine D. A1 - Krüger, Markus A1 - Willmes, Diana M. A1 - Redemann, Nora A1 - Wunderlich, F. Thomas A1 - Brönneke, Hella S. A1 - Merkwirth, Carsten A1 - Kashkar, Hamid A1 - Olkkonen, Vesa M. A1 - Böttger, Thomas A1 - Braun, Thomas A1 - Seibler, Jost A1 - Brüning, Jens C. T1 - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism JF - Nature Cell Biology N2 - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes. Y1 - 2011 U6 - https://doi.org/10.1038/ncb2211 SN - 1465-7392 VL - 13 IS - 4 SP - 434 EP - 446 PB - Nature CY - New York ER - TY - CHAP A1 - Seibler, Jost A1 - Schwenk, Frieder T1 - Transgenic RNAi Applications in the Mouse T2 - Methods in Enzymology : Guide to Techniques in Mouse Development, Part B: Mouse Molecular Genetics. 2nd Edition Y1 - 2010 SN - 978-0-12-384880-2 N1 - Methods in Enzymology : Vol. 477 SP - 367 EP - 386 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Glaser, Stefan A1 - Lubitz, Sandra A1 - Loveland, Kate L. A1 - Ohbo, Kazu A1 - Robb, Lorraine A1 - Schwenk, Frieder A1 - Seibler, Jost A1 - Roellig, Daniela A1 - Kranz, Andrea A1 - Anastassiadis, Konstantinos A1 - Stewart, A. Francis T1 - The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis JF - Epigenetics & Chromatin Y1 - 2009 U6 - https://doi.org/10.1186/1756-8935-2-5 SN - 1756-8935 VL - 2 IS - 5 SP - 1 EP - 16 ER - TY - JOUR A1 - Kotnik, Katarina A1 - Popova, Elena A1 - Todiras, Mihail A1 - Mori, Marcelo A. A1 - Alenina, Natalia A1 - Seibler, Jost A1 - Bader, Michael T1 - Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown JF - Plos One Y1 - 2009 U6 - https://doi.org/10.1371/journal.pone.0005124 VL - 4 IS - 4 SP - e5124 PB - Plos CY - San Francisco, California, US ER - TY - JOUR A1 - Herold, Marco J. A1 - Brandt, Jens van den A1 - Seibler, Jost A1 - Reichardt, Holger M. T1 - Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats JF - Proceedings of the National Academy of Sciences of the United States of America Y1 - 2008 U6 - https://doi.org/10.1073/pnas.0806213105 SN - 1091-6490 VL - 105 IS - 47 SP - 18507 EP - 18512 ER - TY - JOUR A1 - Koch, Linda A1 - Wunderlich, F. Thomas A1 - Seibler, Jost A1 - Könner, A. Christine A1 - Hampel, Brigitte A1 - Irlenbusch, Sigrid A1 - Brabant, Georg A1 - Kahn, C. Ronald A1 - Schwenk, Frieder A1 - Brüning, Jens C. T1 - Central insulin action regulates peripheral glucose and fat metabolism in mice JF - The Journal of Clinical Investigation (JCI) Y1 - 2008 U6 - https://doi.org/10.1172/JCI31073 SN - 1558-8238 VL - 118 IS - 6 SP - 2132 EP - 2147 ER - TY - JOUR A1 - Christoph, Thomas A1 - Bahrenberg, Gregor A1 - Vry, Jean de A1 - Englberger, Werner A1 - Erdmann, Volker A. A1 - Frech, Moritz A1 - Kögel, Babette A1 - Röhl, Thomas A1 - Schiene, Klaus A1 - Schröder, Wolfgang A1 - Seibler, Jost A1 - Kurreck, Jens T1 - Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice JF - Molecular and Cellular Neuroscience Y1 - 2008 U6 - https://doi.org/10.1016/j.mcn.2007.12.006 SN - 1044-7431 VL - 37 IS - 3 SP - 579 EP - 589 ER - TY - JOUR A1 - Cesari, Francesca A1 - Rennekampff, Verena A1 - Vintersten, Kristina A1 - Vuong, Lam Giang A1 - Seibler, Jost A1 - Bode, Jürgen A1 - Wiebel, Franziska F. A1 - Nordheim, Alfred T1 - Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange JF - Genesis : The Journal of Genetics and Development Y1 - 2004 U6 - https://doi.org/10.1002/gene.20003 SN - 1526-968X VL - 38 IS - 2 SP - 87 EP - 92 ER - TY - JOUR A1 - Bode, Jürgen A1 - Schlake, Thomas A1 - Iber, Michaela A1 - Schübeler, Dirk A1 - Seibler, Jost A1 - Snezhkov, Evgeney A1 - Nikolaev, Lev T1 - The transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomes JF - Biological Chemistry Y1 - 2000 U6 - https://doi.org/10.1515/BC.2000.103 SN - 1431-6730 VL - 381 IS - 9-10 SP - 801 EP - 813 ER - TY - JOUR A1 - Feng, Yong-Qing A1 - Seibler, Jost A1 - Alami, Raouf A1 - Eisen, Andrew A1 - Westerman, Karen A. A1 - Leboulch, Philippe A1 - Fiering, Steven A1 - Bouhassira, Eric E. T1 - Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange JF - Journal of Molecular Biology Y1 - 1999 U6 - https://doi.org/10.1006/jmbi.1999.3113 SN - 0022-2836 VL - 292 IS - 4 SP - 779 EP - 785 ER - TY - JOUR A1 - Seibler, Jost A1 - Schübeler, Dirk A1 - Fiering, Steven A1 - Groudine, Mark A1 - Bode, Jürgen T1 - DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs JF - Biochemistry Y1 - 1998 U6 - https://doi.org/10.1021/bi980288t SN - 1520-4995 VL - 37 IS - 18 SP - 6229 EP - 6234 ER - TY - JOUR A1 - Seibler, Jost A1 - Bode, Jürgen T1 - Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assay JF - Biochemistry Y1 - 1997 SN - 1520-4995 VL - 36 IS - 7 SP - 1740 EP - 1747 ER - TY - JOUR A1 - Bode, J. A1 - Bartsch, J. A1 - Boulikas, T. A1 - Iber, M. A1 - Mielke, C. A1 - Schübeler, D. A1 - Seibler, Jost A1 - Benham, C. T1 - Transcription-promoting genomic sites in mammalia: their elucidation and architectural principles JF - Gene therapy & molecular biology Y1 - 1998 SN - 1529-9120 VL - 1 IS - 1 SP - 1 EP - 29 ER - TY - JOUR A1 - Iber, Michaela A1 - Schübeler, Dirk A1 - Seibler, Jost A1 - Höxter, Maria A1 - Bode, Jürgen T1 - Efficient FACS selection procedure for cells undergoing Flp-mediated site-specific conversions JF - Technical Tips Online Y1 - 1998 U6 - https://doi.org/10.1016/S1366-2120(08)70132-6 VL - 4 IS - 1 SP - 25 EP - 29 ER - TY - JOUR A1 - Henken, F. E. A1 - Oosterhuis, K. A1 - Öhlschläger, Peter A1 - Bosch, L. A1 - Hooijberg, E. A1 - Haanen, J. B. A. G. A1 - Steenbergen, R. D. M. T1 - Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7 JF - Vaccine N2 - Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of ‘gene-shuffled’ (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies. Y1 - 2012 U6 - https://doi.org/10.1016/j.vaccine.2012.04.013 SN - 0264-410X VL - 30 IS - 28 SP - 4259 EP - 4266 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Immel, Timo A1 - Grützke, Martin A1 - Späte, Anne-Katrin A1 - Groth, Ulrich A1 - Öhlschläger, Peter A1 - Huhn, Thomas T1 - Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy JF - Chemical Communications N2 - Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model. Y1 - 2012 U6 - https://doi.org/10.1039/C2CC31624B SN - 1364-548X VL - 48 IS - 46 SP - 5790 EP - 5792 PB - Royal Society of Chemistry CY - Cambridge ER - TY - CHAP A1 - Burger, Ulrich A1 - Kirsch, Ansgar A1 - Marcher, Thomas A1 - Höser, Sebastian T1 - Geologisch-geotechnischer Planungsprozess von Tunnelbauten mit Schwerpunkt tiefliegender Tunnel T2 - Beton-Kalender ; Bd. 103: Unterirdisches Bauen, Grundbau, Eurocode 7 Y1 - 2014 SN - 978-3-433-03051-6 ; 978-3-433-60335-2 ; 978-3-433-60508-0 ; 3-433-60508-4 SP - 37 EP - 62 PB - Ernst CY - Berlin ER - TY - BOOK A1 - Kirsch, Ansgar T1 - On the face stability of shallow tunnels in sand. (Advances in geotechnical engineering and tunnelling ; 16) Y1 - 2009 SN - 978-3-8325-2149-3 PB - Logos-Verl. CY - Berlin ER - TY - JOUR A1 - Fellin, Wolfgang A1 - King, Julian A1 - Kirsch, Ansgar A1 - Oberguggenberger, Michael T1 - Uncertainty modelling and sensitivity analysis of tunnel face stability JF - Structural safety N2 - This paper proposes an approach to the choice and evaluation of engineering models with the aid of a typical application in geotechnics. An important issue in the construction of shallow tunnels, especially in weak ground conditions, is the tunnel face stability. Various theoretical and numerical models for predicting the necessary support pressure have been put forth in the literature. In this paper, we combine laboratory experiments performed at the University of Innsbruck with current methods of uncertainty and sensitivity analysis for assessing adequacy, predictive power and robustness of the models. The major issues are the handling of the twofold uncertainty of test results and of model predictions as well as the decision about what are the influential input parameters. Y1 - 2010 U6 - https://doi.org/10.1016/j.strusafe.2010.06.001 SN - 0167-4730 VL - 32 IS - 6 SP - 402 EP - 410 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kirsch, Ansgar T1 - Experimental investigation of the face stability of shallow tunnels in sand JF - Acta Geotechnica N2 - Various models have been proposed for the prediction of the necessary support pressure at the face of a shallow tunnel. To assess their quality, the collapse of a tunnel face was modelled with small-scale model tests at single gravity. The development of the failure mechanism and the support force at the face in dry sand were investigated. The observed displacement patterns show a negligible influence of overburden on the extent and evolution of the failure zone. The latter is significantly influenced, though, by the initial density of the sand: in dense sand a chimney-wedge-type collapse mechanism developed, which propagated towards the soil surface. Initially, loose sand did not show any discrete collapse mechanism. The necessary support force was neither influenced by the overburden nor the initial density. A comparison with quantitative predictions by several theoretical models showed that the measured necessary support pressure is overestimated by most of the models. Those by Vermeer/Ruse and Léca/Dormieux showed the best agreement to the measurements. Y1 - 2010 U6 - https://doi.org/10.1007/s11440-010-0110-7 SN - 1861-1125 VL - 5 IS - 1 SP - 43 EP - 62 PB - Springer CY - Berlin ER - TY - JOUR A1 - Kolymbas, Dimitrios A1 - Kirsch, Ansgar T1 - Zum Erddruck auf Lawinenschutzgalerien JF - Bautechnik : Zeitschrift für den gesamten Ingenieurbau Y1 - 2009 U6 - https://doi.org/10.1002/bate.200910075 SN - 1437-0999 (E-Journal); 0005-6820 (Print); 0932-8351 (Print) N1 - Auch gedruckt in der Bibliothek Bayernallee vorhanden VL - Vol. 86 IS - Iss. 12 SP - 774 EP - 779 ER - TY - JOUR A1 - Kirsch, Ansgar A1 - Piazzi, Lukas T1 - Numerical investigation of the effectiveness of a bored pile wall for the minimisation of settlement resulting from tunnel driving T1 - Numerische Untersuchung der Wirkungsweise einer Bohrpfahlwand zur Minimierung der Setzungen infolge Tunnel JF - Geomechanics and tunnelling Y1 - 2009 U6 - https://doi.org/10.1002/geot.200900063 SN - 1865-7362 VL - Vol. 2 IS - Iss. 6 SP - 753 EP - 765 ER - TY - JOUR A1 - Kirsch, Ansgar T1 - Experimentelle Untersuchung des Ortsbrustversagens seichter Tunnel JF - Österreichische Bauwirtschaft Y1 - 2008 IS - Sondernr. SP - 6 EP - 9 ER - TY - RPRT A1 - Kirsch, Ansgar T1 - Vermittlung wissenschaftlicher Schreibkompetenzen unter Einbeziehung aktueller Forschungsinhalte T2 - Schaufenster Lehre Y1 - 2008 ER - TY - CHAP A1 - Kirsch, Ansgar A1 - Felber, W. A1 - Marcher, Thomas A1 - Fuchs, W. T1 - Geotechnical challenges during design and construction of a ski resort in Azerbaijan T2 - Geotechnics of roads and railways : proceedings of the 15th Danube - European Conference on Geotechnical Engineering : 9-11 September 2014, Vienna, Austria Y1 - 2014 SN - 978‐3‐902593‐01‐6 SP - 757 EP - 762 PB - ÖIAV - Österreichischer Ingenieur- und Architekten-Verein CY - Wien ER - TY - JOUR A1 - Kolymbas, Dimitrios A1 - Fellin, W. A1 - Kirsch, Ansgar T1 - Squeezing due to stress relaxation in foliated rock JF - International journal for numerical and analytical methods in geomechanics Y1 - 2006 U6 - https://doi.org/10.1002/nag.530 SN - 1096-9853 (E-Journal); 0363-9061 (Print) VL - Vol. 30 IS - Iss. 13 SP - 1357 EP - 1367 ER - TY - CHAP A1 - Biener, Ernst T1 - Abfallwirtschaft T2 - Wendehorst Beispiele aus der Baupraxis. - 3. Aufl. Y1 - 2009 SN - 978-3-8348-0684-0 ; 978-3-8348-9997-2 U6 - https://doi.org/10.1007/978-3-8348-9997-2_16 SP - 463 EP - 499 PB - Springer Vieweg CY - Wiesbaden ER - TY - CHAP A1 - Feiser, Johannes T1 - Geotechnik T2 - Wendehorst Beispiele aus der Baupraxis. - 1. Aufl. Y1 - 2005 SN - 3-519-00489-5 ; 978-3-519-00489-9 SP - 195 EP - 220 PB - Teubner CY - Stuttgart ER - TY - CHAP A1 - Strohmeier, Andreas T1 - Wasserwirtschaft T2 - Wendehorst Beispiele aus der Baupraxis. - 1. Aufl. Y1 - 2005 SN - 3-519-00489-5 ; 978-3-519-00489-9 SP - 221 EP - 254 PB - Teubner CY - Stuttgart ER - TY - JOUR A1 - Scheer, Nico A1 - Snaith, Mike A1 - Wolf, C. Roland A1 - Seibler, Jost T1 - Generation and utility of genetically humanized mouse models JF - Drug Discovery Today Y1 - 2013 U6 - https://doi.org/10.1016/j.drudis.2013.07.007 SN - 1359-6446 VL - Vol 18 IS - 23-24 SP - 1200 EP - 1211 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bouwman, Peter A1 - Gulden, Hanneke van der A1 - Heijden, Ingrid van der A1 - Drost, Rinske A1 - Klijn, Christiaan N. A1 - Prasetyanti, Pramudita A1 - Pieterse, Mark A1 - Wientjens, Ellen A1 - Seibler, Jost A1 - Hogervorst, Frank B. L. A1 - Jonkers, Jos T1 - A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants JF - Cancer Discovery Y1 - 2013 U6 - https://doi.org/10.1158/2159-8290.CD-13-0094 SN - 2159-8290 IS - 3 SP - 1142 EP - 1152 ER - TY - JOUR A1 - Michalak, Ewa Malgorzata A1 - Nacerddine, Karim A1 - Pietersen, Alexandra A1 - Beuger, Vincent A1 - Pawlitzky, Inka A1 - Cornelissen-Steijger, Paulien A1 - Wientjens, Ellen A1 - Tanger, Ellen A1 - Seibler, Jost A1 - Lohuizen, Maarten van A1 - Jonkers, Jos T1 - Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool JF - Stem Cells Y1 - 2013 U6 - https://doi.org/10.1002/stem.1437 SN - 1549-4918 VL - Vol 31 IS - 9 SP - 1910 EP - 1920 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Gebeshuber, Christoph A. A1 - Kornauth, Christoph A1 - Dong, Lihua A1 - Sierig, Ralph A1 - Seibler, Jost A1 - Reiss, Martina A1 - Tauber, Stefanie A1 - Bilban, Martin A1 - Wang, Shijun A1 - Kain, Renate A1 - Böhmig, Georg A. A1 - Moeller, Marcus J. A1 - Gröne, Hermann-Josef A1 - Englert, Christoph A1 - Martinez, Javier A1 - Kerjaschki, Dontscho T1 - Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1 JF - Nature Medicine Y1 - 2013 U6 - https://doi.org/10.1038/nm.3142 SN - 1078-8956 VL - 19 IS - 4 SP - 481 EP - 487 ER - TY - JOUR A1 - Kornfeld, Jan-Wilhelm A1 - Baitzel, Catherina A1 - Könner, A. Christine A1 - Nicholls, Hayley T. A1 - Vogt, Merly C. A1 - Herrmanns, Karolin A1 - Scheja, Ludger A1 - Haumaitre, Cécile A1 - Wolf, Anna M. A1 - Knippschild, Uwe A1 - Seibler, Jost A1 - Cereghini, Silvia A1 - Heeren, Joerg A1 - Stoffel, Markus A1 - Brüning, Jens C. T1 - Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b JF - Nature Y1 - 2013 SN - 0028-0836 U6 - https://doi.org/10.1038/nature11793 VL - 494 IS - 7435 SP - 111 EP - 115 PB - Springer Nature CY - Cham ER - TY - CHAP A1 - Nabe, C. A1 - Borchert, Jörg ED - Hake, Jürgen-Friedrich T1 - Risikomanagement von EVU in liberalisierten Strommärkten T2 - Liberalisierung des Energiemarktes : Vortragsmanuskripte des 5. Ferienkurses "Energieforschung" vom 27. September - 1. Oktober 1999 im Congrescentrum Rolduc und im Forschungszentrum Jülich Y1 - 1999 SN - 3-89336-248-7 N1 - Schriften des Forschungszentrums Jülich : Reie Energietechnik ; 8 SP - 203 EP - 216 PB - Forschungszentrum CY - Jülich ER - TY - CHAP A1 - Borchert, Jörg T1 - Der Elektrizitätsmarkt in Indonesien und Beteiligungsmöglichkeiten privater Unternehmen T2 - Investitionsführer ASEAN, Indochina, 1997 : Brunei, Indonesien, Kambodscha, Laos, Malaysia, Myanmar, Philippinen, Singapur, Thailand, Vietnam Y1 - 2015 SP - 42 EP - 52 PB - Berliner Bank AG CY - Berlin ET - Stand: Mai 1997 ER - TY - JOUR A1 - Wollert, Jörg T1 - Bluetooth: Funk für alle(s)? : 10 Jahre Bluetooth: ein Technologie-Über- und -Ausblick JF - Elektronik : Fachmedium für industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium für Entwicklungen funkbasierter Systeme Y1 - 2008 IS - Okt. SP - 36 EP - 43 ER - TY - BOOK A1 - Vismann, Ulrich T1 - Wendehorst Beispiele aus der Baupraxis / Ulrich Vismann (Hrsg.). - 5., durchges. und aktualis. Aufl. Y1 - 2015 SN - 978-3-658-01680-7 (print) ; 978-3-658-01681-4 (e-Book) U6 - https://doi.org/10.1007/978-3-658-01681-4 PB - Springer Vieweg CY - Wiesbaden ER - TY - CHAP A1 - Vismann, Ulrich A1 - Schüller, Michael T1 - Stahlbetonbau T2 - Wendehorst Beispiele aus der Baupraxis. / 5. Auflage N2 - Das Kapitel Stahlbetonbau besteht aus einer Formelsammlung (Teil A) sowie einem Praxisbeispiel (Teil B). In dem Praxisbeispiel werden exemplarisch die erforderlichen Rechenschritte und Nachweise zur Bemessung im GZT und GZG nach Eurocode 2 [1] vorgestellt. Die Hinweise im Text beziehen sich, soweit nicht explizit erwähnt, auf Wendehorst, Bautechnische Zahlentafeln, 35. Auflage, „Stahlbeton- und Spannbetonbau nach Eurocode 2“ [2]. Die zum Praxisbeispiel zugehörigen Konstruktions- und Bewehrungszeichnungen stehen im Onlineportal zu diesem Buch zum kostenlosen Download bereit (siehe unter www.springer.com). Y1 - 2015 SN - 978-3-658-01680-7 ; 978-3-658-01681-4 U6 - https://doi.org/10.1007/978-3-658-01681-4_9 SP - 243 EP - 322 PB - Springer Vieweg CY - Wiesbaden ER - TY - CHAP A1 - Feiser, Johannes T1 - Geotechnik T2 - Wendehorst Beispiele aus der Baupraxis. / 5. Auflage Y1 - 2015 SN - 978-3-658-01689-0 ; 978-3-410-24199-7 U6 - https://doi.org/10.1007/978-3-658-01681-4_14 SP - 547 EP - 598 PB - Springer Vieweg CY - Wiesbaden ER - TY - CHAP A1 - Strohmeier, Andreas T1 - Siedlungswasserwirtschaft T2 - Wendehorst Beispiele aus der Baupraxis. / 5. Auflage N2 - Nachfolgende Ausführungen und Berechnungsbeispiele beziehen sich auf Kapitel 19 Siedlungswasserwirtschaft im „Wendehorst: Bautechnische Zahlentafeln 35. Auflage 2015“ (abgekürzt: BZ). Für den Bau von Anlagen der Siedlungswasserwirtschaft sind ebenso die Grundlagen der Hydraulik zu berücksichtigen. Aus diesem Grunde sind auch die entsprechenden Ausführungen zur Hydraulik zu beachten. Y1 - 2015 SN - 978-3-658-01689-0 ; 978-3-410-24199-7 U6 - https://doi.org/10.1007/978-3-658-01681-4_16 SP - 635 EP - 678 PB - Springer Vieweg CY - Wiesbaden ER - TY - CHAP A1 - Biener, Ernst T1 - Abfallwirtschaft T2 - Wendehorst Beispiele aus der Baupraxis. - 5. Aufl. Y1 - 2015 SN - 978-3-658-01689-0 ; 978-3-410-24199-7 U6 - https://doi.org/10.1007/978-3-658-01681-4_17 SP - 680 EP - 723 PB - Springer Vieweg CY - Wiesbaden ER - TY - BOOK A1 - Vismann, Ulrich T1 - Wendehorst Beispiele aus der Baupraxis / Ulrich Vismann (Hrsg.). - 4., durchges. und aktualis. Aufl. Y1 - 2012 SN - 978-3-8348-0999-5 ; 978-3-8348-8229-5 U6 - https://doi.org/10.1007/978-3-8348-8229-5 PB - Springer Vieweg CY - Wiesbaden ER - TY - JOUR A1 - Oberländer, Jan A1 - Kirchner, Patrick A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Strategies in developing thin-film sensors for monitoring aseptic food processes : Theoretical considerations and investigations of passivation materials JF - Electrochimica Acta N2 - The sterilization of packages in aseptic food processes is highly significant to maintain a consumer-safe product with extended shelf-life. Today, the sterilization of food packages is predominantly accomplished by gaseous hydrogen peroxide (H2O2) in combination with heat. In order to monitor this sterilization process, calorimetric gas sensors as differential set-up of two platinum temperature sensors representing a catalytically active (additionally deposition of MnO2) and a passive segment have been recently developed. The temperature rise of the exothermic decomposition serves as an indicator of the present H2O2 concentration. In the present work, a theoretical approach considering the sensor’s thermochemistry and physical transport phenomena was formulated to evaluate the temperature rise based on the energy content of gaseous H2O2. In a further part of this work, three polymers have been analyzed with respect to their application as passivation materials. The examined polymers are photoresist SU-8, perfluoroalkoxy (PFA) and fluorinated ethylene propylene (FEP). Thermal analyses by means of differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) have been conducted to determine the operation limits of the polymers. The overall chemical resistance and stability of the polymers against the harsh environmental conditions during the sterilization process have been examined by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Y1 - 2015 U6 - https://doi.org/10.1016/j.electacta.2015.06.126 SN - 0013-4686 VL - 183 SP - 130 EP - 136 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kuperjans, Isabel A1 - Weitzel, J. T1 - Energiedesign 2020 : Sichere Strom- und Wärmeversorgung für die Industrie JF - TAB: das Fachmedium der TGA-Branche Y1 - 2015 SN - 0341-2032 IS - 3 SP - 105 EP - 107 PB - Bauverlag CY - Gütersloh ER - TY - JOUR A1 - Hoeveler, Bastian A1 - Janser, Frank A1 - Bindewald, Thorsten A1 - Gebhardt, Andreas T1 - Entwurf, Fertigung und Untersuchung eines Windkanalmodells eines innovativen, senkrechtstartenden Kleinflugzeuges JF - RTejournal - Forum für Rapid Technologie Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0009-2-42921 SN - 1614-0923 IS - 12 SP - 1 EP - 5 PB - Fachhochschule Aachen CY - Aachen ER - TY - JOUR A1 - Wollert, Jörg T1 - Echtzeit-Ethernet : Protokoll-Reigen JF - elektroniknet.de Y1 - 2015 ER - TY - CHAP A1 - Breuer, Lars A1 - Raue, Markus A1 - Mang, Thomas A1 - Schöning, Michael Josef A1 - Thoelen, Ronald A1 - Wagner, Torsten T1 - Light-stimulated hydrogel actuators with incorporated graphene oxide for microfluidic applications T2 - 12. Dresdner Sensor-Symposium 2015 Y1 - 2015 U6 - https://doi.org/10.5162/12dss2015/P5.8 SP - 206 EP - 209 ER - TY - CHAP A1 - Oberländer, Jan A1 - Jildeh, Zaid B. A1 - Kirchner, Patrick A1 - Wendeler, Luisa A1 - Bromm, Alexander A1 - Iken, Heiko A1 - Wagner, Patrick A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Experimental and numerical evaluation of interdigitated electrode array for monitoring gaseous sterilization processes T2 - 12. Dresdner Sensor-Symposium 2015 Y1 - 2015 U6 - https://doi.org/10.5162/12dss2015/P3.11 SP - 163 EP - 168 ER - TY - JOUR A1 - Miyamato, Ko-ichiro A1 - Sakakita, Sakura A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Application of chemical imaging sensor to in-situ pH imaging in the vicinity of a corroding metal surface JF - Electrochimica Acta N2 - The chemical imaging sensor was applied to in-situ pH imaging of the solution in the vicinity of a corroding surface of stainless steel under potentiostatic polarization. A test piece of polished stainless steel was placed on the sensing surface leaving a narrow gap filled with artificial seawater and the stainless steel was corroded under polarization. The pH images obtained during polarization showed correspondence between the region of lower pH and the site of corrosion. It was also found that the pH value in the gap became as low as 2 by polarization, which triggered corrosion. Y1 - 2015 U6 - https://doi.org/10.1016/j.electacta.2015.07.184 SN - 0013-4686 VL - 183 SP - 137 EP - 142 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hamad, E. M. A1 - Bilatto, S. E. R. A1 - Adly, N. Y. A1 - Correa, D. S. A1 - Wolfrum, B. A1 - Schöning, Michael Josef A1 - Offenhäusser, A. A1 - Yakushenko, A. T1 - Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices JF - Lab on a Chip N2 - Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing. Y1 - 2016 U6 - https://doi.org/10.1039/C5LC01195G SN - 1473-0189 VL - 16 IS - 1 SP - 70 EP - 74 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Hauser, C. A1 - Kotliar, Konstantin A1 - Tholen, S. A1 - Hasenau, A. A1 - Suttmann, Y. A1 - Renders, L. A1 - Heemann, U. A1 - Baumann, M. A1 - Schmaderer, C. T1 - Dynamische retinale Gefäßreaktion bei Hämodialysepatienten JF - Nieren- und Hochdruckkrankheiten Y1 - 2015 U6 - https://doi.org/10.5414/NHX01743a SN - 0300-5224 VL - 44 IS - 11 SP - 480 EP - 480 PB - Dustri-Verlag CY - Oberhaching ER - TY - JOUR A1 - Gebhardt, Andreas T1 - 3D-Druck ist überall. Modische Accessoires, Kleidung, Medikamente, Nahrungsmittel, Autos, Häuser, Waffen, Büsten, Musikinstrumente - alles geht JF - Kunststoffe Y1 - 2015 SN - 0023-5563 VL - 105 IS - 10 SP - 62 EP - 70 PB - Hanser CY - München ER - TY - CHAP A1 - Roosen, Petra A1 - Feyerl, Günter T1 - Gender-specific perception and utilization of personal use vehicles T2 - FISITA World Automotive Congress 2014 : Maastricht, The Netherlands, 2 - 6 June / [organised by the International Federation of Automotive Engineering Societies (FISITA) ...]. Bd. 1 Y1 - 2015 SN - 978-1-5108-0209-4 SP - 418 EP - 425 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Kilic, S. A. A1 - Raatschen, Hans-Jürgen A1 - Astaneh-Asl, A. A1 - Apaydin, N. M. T1 - Finite element modeling of the Fatih Sultan Mehmet Suspension Bridge T2 - Multi-Span Large Bridges - Proceedings of the International Conference on Multi-Span Large Bridges Y1 - 2015 SN - 9781138027572 SP - 1169 EP - 1173 PB - CRC Press CY - Leiden ER - TY - JOUR A1 - Fischer, Felix A1 - Selver, M. Alper A1 - Gezer, Sinem A1 - Dicle, Oguz A1 - Hillen, Walter T1 - Systematic Parameterization, Storage, and Representation of Volumetric DICOM Data JF - Journal of Medical and Biological Engineering Y1 - 2015 U6 - https://doi.org/10.1007/s40846-015-0097-5 SN - 2199-4757 VL - 35 IS - 6 SP - 709 EP - 723 PB - Springer CY - Berlin ER - TY - CHAP A1 - Horikawa, Atsushi A1 - Kazari, Masahide A1 - Okada, Kunio A1 - Funke, Harald A1 - Keinz, Jan A1 - Kusterer, Karsten A1 - Haji Ayed, Anis T1 - Developments of Hydrogen Dry Low Emission Combustion Technology T2 - Annual Congress of Gas Turbine Society Japan, 2015 Y1 - 2015 N1 - Abstract in engl.; Text in japanisch ER - TY - BOOK A1 - Hüning, Felix T1 - Sensoren und Sensorschnittstellen Y1 - 2016 SN - 978-3-11-043854-3 SN - 978-3-11-043855-0 (Online-Ausgabe) PB - De Gruyter Oldenbourg CY - Berlin ER - TY - BOOK A1 - Janser, Frank A1 - Havermann, Marc T1 - Inkompressible Strömungen Y1 - 2015 SN - 978-3-86130-446-3 N1 - Strömungslehre und Aerodynamik ; 1 PB - Verlagshaus Mainz GmbH CY - Aachen ET - 3. Aufl. ER - TY - JOUR A1 - Fredebeul-Krein, Markus T1 - Volkswirtschaftslehre : Die Klausur JF - Das Wirtschaftsstudium : wisu ; Zeitschrift für Ausbildung, Prüfung, Berufseinstieg und Fortbildung Y1 - 2015 SN - 0340-3084 VL - 45 IS - 11 SP - 1253 EP - 1255 PB - Lange CY - Düsseldorf ER - TY - JOUR A1 - Fredebeul-Krein, Markus T1 - Wettbewerbspolitische Leitbilder JF - Das Wirtschaftsstudium : wisu ; Zeitschrift für Ausbildung, Examen, Berufseinstieg und Fortbildung Y1 - 2015 SN - 0340-3084 VL - 45 IS - 4 SP - 483 EP - 486 PB - Lange CY - Düsseldorf ER - TY - CHAP A1 - Wollert, Jörg T1 - Wireless systems for machinery safety : Requirements and solutions for wireless real time systems T2 - 16th International Conference on Research and Education in Mechatronics (REM), 2015 Y1 - 2015 SN - 978-3-945728-01-7 U6 - https://doi.org/10.1109/REM.2015.7380377 SP - 88 EP - 91 ER - TY - CHAP A1 - Nakagawa, Masaki A1 - Kallweit, Stephan A1 - Michaux, Frank A1 - Hojo, Teppei T1 - Typical Velocity Fields and Vortical Structures around a Formula One Car, based on Experimental Investigations using Particle Image Velocimetry T2 - SAE International Journal of Passenger Cars - Mechanical Systems Y1 - 2016 U6 - https://doi.org/10.4271/2016-01-1611 SN - 1946-4002 ER - TY - JOUR A1 - Fredebeul-Krein, Markus T1 - Warum staatliche Kaufprämien für Elektroautos abzulehnen sind JF - Wirtschaftliche Freiheit : das ordnungspolitische Journal N2 - Im Jahr 2015 wurden in Deutschland über drei Millionen Benzinautos und lediglich 12.363 Elektroautos neu zugelassen. Das ursprünglich von der Bundesregierung vorgegebene Ziel, dass bis 2020 eine Million E-Autos auf deutschen Straßen fahren (und bis 2030 sechs Millionen), rückt damit in immer weitere Ferne. Um das Ziel dennoch zu erreichen, plant die Bundesregierung nun eine staatli­che Prämie für den Kauf von Elektroautos: Umwelt-, Verkehrs- und Wirtschaftsministerium haben gemeinsam ein Konzept entworfen, dem zufolge private Käufer zukünftig einen Zuschuss von 5.000 Euro beim Erwerb eines Elektroautos bekommen sollen. 40 Prozent dieses Zuschusses soll von den Autoherstellern getragen werden. Das Programm, das weitere ausgabenwirksame öffentli­che Maßnahmen vorsieht, würde Kosten in Milliarden­höhe verursachen. Die beabsichtigte Subventionierung wirft die Frage auf, ob diese wirtschaftlich sinnvoll sind. Y1 - 2016 N1 - Hinweis: Dieser Text ist zugleich als Ausgabe Nr. 04/2016 der Reihe Ordnungspolitischer Kommentar des Instituts für Wirtschaftspolitik an der Universität zu Köln und des Otto-Wolff-Instituts für Wirtschaftsordnung erschienen. VL - 2016 IS - 4 PB - Alexander B. Brunner CY - Würzburg ER - TY - JOUR A1 - Bayon, Arnau A1 - Valero, Daniel A1 - Garcia-Bartual, Rafael A1 - Vallés-Morán, Francisco José A1 - López-Jiménez, P. Amparo T1 - Performance assessment of OpenFOAM and FLOW-3D in the numerical modeling of a low Reynolds number hydraulic jump JF - Environmental Modelling & Software N2 - A comparative performance analysis of the CFD platforms OpenFOAM and FLOW-3D is presented, focusing on a 3D swirling turbulent flow: a steady hydraulic jump at low Reynolds number. Turbulence is treated using RANS approach RNG k-ε. A Volume Of Fluid (VOF) method is used to track the air–water interface, consequently aeration is modeled using an Eulerian–Eulerian approach. Structured meshes of cubic elements are used to discretize the channel geometry. The numerical model accuracy is assessed comparing representative hydraulic jump variables (sequent depth ratio, roller length, mean velocity profiles, velocity decay or free surface profile) to experimental data. The model results are also compared to previous studies to broaden the result validation. Both codes reproduced the phenomenon under study concurring with experimental data, although special care must be taken when swirling flows occur. Both models can be used to reproduce the hydraulic performance of energy dissipation structures at low Reynolds numbers. Y1 - 2016 SN - 1364-8152 U6 - https://doi.org/10.1016/j.envsoft.2016.02.018 VL - 80 SP - 322 EP - 335 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Yu, Bing A1 - Isoda, Hiroko A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Visualization of the recovery process of defects in a cultured cell layer by chemical imaging sensor JF - Sensors and Actuators B: Chemical N2 - The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) in the sample. In this study, a novel cell assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the recovery of defects in a cell layer brought into proximity of the sensing surface. A reduced impedance at a defect formed artificially in a cell layer was successfully visualized in a photocurrent image. The cell layer was cultured over two weeks, during which the temporal change of the photocurrent distribution corresponding to the recovery of the defect was observed. Y1 - 2016 U6 - https://doi.org/10.1016/j.snb.2016.04.018 SN - 0925-4005 VL - 236 SP - 965 EP - 969 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Dantism, Shahriar A1 - Takenaga, Shoko A1 - Wagner, Patrick A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system JF - Physica status solidi (a) N2 - On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable “down times” during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements. Y1 - 2016 U6 - https://doi.org/10.1002/pssa.201533043 SN - 1862-6300 VL - 213 IS - 6 SP - 1479 EP - 1485 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Schreiber, Marc A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - Cost-efficient quality assurance of natural language processing tools through continuous monitoring with continuous integration T2 - 3rd International Workshop on Software Engineering Research and Industrial Practice Y1 - 2016 U6 - https://doi.org/10.1145/2897022.2897029 N1 - SER&IP’16, May 17 2016, Austin, TX, USA SP - 46 EP - 52 ER - TY - JOUR A1 - Wollert, Jörg T1 - Industrial Internet of Things : Seifenblase oder Revolution JF - Elektronik Y1 - 2016 SN - 0013-5658 N1 - gedruckt in der Bereichsbibliothek Eupener Str. unter der Signatur Z 263 IS - 7 SP - 39 EP - 45 PB - WEKA-Fachmedien CY - München ER - TY - CHAP A1 - Hüning, Felix T1 - Power Semiconductors for the automotive 48V board net T2 - PCIM Europe 2016 Conference Proceedings Y1 - 2016 SN - 978-3-8007-4186-1 SP - 1963 EP - 1969 PB - VDE Verl. CY - Berlin ER - TY - JOUR A1 - Breuer, Lars A1 - Raue, Markus A1 - Strobel, M. A1 - Mang, Thomas A1 - Schöning, Michael Josef A1 - Thoelen, R. A1 - Wagner, Torsten T1 - Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems JF - Physica status solidi (a) N2 - Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium. Y1 - 2016 U6 - https://doi.org/10.1002/pssa.201533056 SN - 1862-6300 VL - 213 IS - 6 SP - 1520 EP - 1525 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Pookhalil, Ali A1 - Amoabediny, Ghassem A1 - Tabesh, Hadi A1 - Behbahani, Mehdi A1 - Mottaghy, Khosrow T1 - A new approach for semiempirical modeling of mechanical blood trauma JF - The international journal of artificial organs N2 - Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis. Y1 - 2016 U6 - https://doi.org/10.5301/ijao.5000474 SN - 1724-6040 VL - 39 IS - 4 SP - 171 EP - 177 PB - Sage CY - London ER - TY - BOOK A1 - Gebhardt, Andreas A1 - Hötter, Jan-Steffen T1 - Additive manufacturing : 3D printing for prototyping and manufacturing Y1 - 2016 SN - 978-1-56990-582-1 ; 978-1-56990-583-8 PB - Hanser Publishers CY - Munich ER - TY - BOOK A1 - Hallmann, Willi T1 - (Meine) Erinnerungen an Jesco von Puttkamer : zusammengestellt anlässlich des Todes von Jesco von Puttkamer am 27. Dezember 2012 Y1 - 2015 SN - 978-3-86460-271-9 ; 3-86460-271-8 PB - Pro BUSINESS digital printing Deutschlang GmbH CY - Berlin ER - TY - BOOK A1 - Iomdina, E. N. A1 - Bauer, S. M. A1 - Kotliar, Konstantin T1 - БИОМЕХАНИКА ГЛАЗА: ТЕОРЕТИЧЕСКИЕ АСПЕКТЫ И КЛИНИЧЕСКИЕ ПРИЛОЖЕНИЯ T2 - Eye biomechanics : theoretical aspects and clinical applications Y1 - 2015 SN - 978-5-903025-57-2 PB - Real Time CY - Moscow ER - TY - JOUR A1 - Lind, Thorsten Patric T1 - Insolvenzanfechtung: Keine Gläubigerbenachteiligung bei Ablösezahlung gegen Forderungsverzicht JF - Der Betrieb N2 - Schwerpunkt einer vorinsolvenzlichen Sanierung ist i.d.R., dass einzelne Gläubiger gegen Teilzahlungen auf ihre Forderungen verzichten und somit dem Unternehmen den notwendigen finanziellen Freiraum für einen Turnaround geben. Die Motivation der Gläubiger für einen Verzicht ist dabei auch die Überlegung, dass eine quotale Befriedigung im Rahmen eines Insolvenzverfahrens oft wesentlich geringer ausfallen würde als die durch den Vergleich realisierte Teilzahlung. Das Risiko, im Falle der Insolvenz eine Teilzahlung im Rahmen der Insolvenzanfechtung aber wieder zurückgewähren zu müssen, macht einen Forderungsverzicht weniger attraktiv. Mit Urteil vom 28.01.2016 hat der BGH nun entschieden, dass eine Insolvenzanfechtung mangels Gläubigerbenachteiligung ausscheidet, wenn der in der Teilzahlung liegende Vermögensverlust durch den damit verbundenen Verzicht auf die Restforderung voll ausgeglichen wird. Im Folgenden wird untersucht, ob dieses Urteil als Blaupause für eine anfechtungsfeste Restrukturierung einzelner Verbindlichkeiten dienen kann. Y1 - 2016 SN - 0005-9935 N1 - Printausgabe in der Bibliothek Eupener Str. vorhanden: 43 Z 364 VL - 69 IS - 17 SP - 999 EP - 1001 PB - Fachmedien Otto Schmidt CY - Düsseldorf ER - TY - CHAP A1 - Kasper, Katharina A1 - Schiffels, Johannes A1 - Krafft, Simone A1 - Kuperjans, Isabel A1 - Elbers, Gereon A1 - Selmer, Thorsten T1 - Biogas Production on Demand Regulated by Butyric Acid Addition T2 - IOP Conference Series: Earth and Environmental Science. Bd. 32 Y1 - 2016 U6 - https://doi.org/10.1088/1755-1315/32/1/012009 SN - 1755-1315 N1 - ICARET 2016, International Conference on Advances in Renewable Energy and Technologies, Putrajaya, MY, Feb 23-25, 2016 VL - 32 SP - 012009/1 EP - 012009/4 ER - TY - JOUR A1 - Bertz, Morten A1 - Schöning, Michael Josef A1 - Molinnus, Denise A1 - Homma, Takayuki T1 - Influence of temperature, light, and H₂O₂ concentration on microbial spore inactivation: in-situ Raman spectroscopy combined with optical trapping JF - Physica status solidi (a) applications and materials science N2 - To gain insight on chemical sterilization processes, the influence of temperature (up to 70 °C), intense green light, and hydrogen peroxide (H₂O₂) concentration (up to 30% in aqueous solution) on microbial spore inactivation is evaluated by in-situ Raman spectroscopy with an optical trap. Bacillus atrophaeus is utilized as a model organism. Individual spores are isolated and their chemical makeup is monitored under dynamically changing conditions (temperature, light, and H₂O₂ concentration) to mimic industrially relevant process parameters for sterilization in the field of aseptic food processing. While isolated spores in water are highly stable, even at elevated temperatures of 70 °C, exposure to H₂O₂ leads to a loss of spore integrity characterized by the release of the key spore biomarker dipicolinic acid (DPA) in a concentration-dependent manner, which indicates damage to the inner membrane of the spore. Intensive light or heat, both of which accelerate the decomposition of H₂O₂ into reactive oxygen species (ROS), drastically shorten the spore lifetime, suggesting the formation of ROS as a rate-limiting step during sterilization. It is concluded that Raman spectroscopy can deliver mechanistic insight into the mode of action of H₂O₂-based sterilization and reveal the individual contributions of different sterilization methods acting in tandem. KW - hydrogen peroxide KW - optical spore trapping KW - Raman spectroscopy KW - sterilization conditions KW - temperature Y1 - 2024 U6 - https://doi.org/10.1002/pssa.202300866 SN - 1862-6319 (Online) SN - 1862-6300 (Print) N1 - Corresponding author: Michael J. Schöning IS - Early View PB - Wiley-VCH CY - Berlin ER - TY - CHAP A1 - Kraft, Bodo A1 - Kohl, Philipp A1 - Meinecke, Matthias ED - Bernert, Christian ED - Scheurer, Steffen ED - Wehnes, Harald T1 - Analyse und Nachverfolgung von Projektzielen durch Einsatz von Natural Language Processing T2 - KI in der Projektwirtschaft : was verändert sich durch KI im Projektmanagement? Y1 - 2024 SN - 978-3-3811-1132-9 (Online) SN - 978-3-3811-1131-2 (Print) U6 - https://doi.org/10.24053/9783381111329 SP - 157 EP - 167 PB - UVK Verlag ER - TY - CHAP A1 - Finkenberger, Isabel Maria ED - Büscher, Barbara ED - Krasny, Elke ED - Ortmann, Lucie T1 - Transformatives Handeln als disziplinüberschreitende, kollektive Aktion. Stadtentwicklung trifft künstlerische und kollaborative Handlungspraxen T2 - Porös-Werden : geteilte Räume, urbane Dramaturgien, performatives Kuratieren Y1 - 2024 SN - 978-3-98514-543-0 SP - 144 EP - 158 PB - Turia + Kant CY - Wien ER - TY - BOOK A1 - Laumann, Jörg A1 - Wolf, Christian T1 - Stahlbau 1 : Bemessung von Stahlbauten nach Eurocode mit zahlreichen Beispielen Y1 - 2024 SN - 978-3-658-41323-1 (Print) SN - 978-3-658-41324-8 (eBook) U6 - https://doi.org/10.1007/978-3-658-41324-8 PB - Springer Vieweg CY - Wiesbaden ET - 26., überarbeitete und aktualisierte Auflage ER - TY - JOUR T1 - Dimensionen Nr. 30 / 2023: Magazin der FH Aachen University of Applied Sciences - Der Mensch im Mittelpunkt N2 - 06| Warum es gemeinsam besser geht 10| Interview 14| Wer ist hier der Boss? 18| Schnittstelle zwischen Mensch und Technik 22| Zweite Heimat Jülich 28| Zwischen Angst und Hoffnung 32| Eine Sternstunde für die FH Aachen 36| Gegen alle Widerstände 38| Ein Ort, der bleibt 42| Der Aufblühende 46| Der Computer sitzt am Steuer 52| Da geht das Herz auf 54| Hoch hinaus 58| Beratungsangebote 60| Das alte Schätzchen T3 - Dimensionen - Magazin der FH Aachen University of Applied Sciences - 01/2023 Y1 - 2023 CY - Aachen ER - TY - JOUR A1 - Schoenrock, Britt A1 - Muckelt, Paul E. A1 - Hastermann, Maria A1 - Albracht, Kirsten A1 - MacGregor, Robert A1 - Martin, David A1 - Gunga, Hans-Christian A1 - Salanova, Michele A1 - Stokes, Maria J. A1 - Warner, Martin B. A1 - Blottner, Dieter T1 - Muscle stiffness indicating mission crew health in space JF - Scientific Reports N2 - Muscle function is compromised by gravitational unloading in space affecting overall musculoskeletal health. Astronauts perform daily exercise programmes to mitigate these effects but knowing which muscles to target would optimise effectiveness. Accurate inflight assessment to inform exercise programmes is critical due to lack of technologies suitable for spaceflight. Changes in mechanical properties indicate muscle health status and can be measured rapidly and non-invasively using novel technology. A hand-held MyotonPRO device enabled monitoring of muscle health for the first time in spaceflight (> 180 days). Greater/maintained stiffness indicated countermeasures were effective. Tissue stiffness was preserved in the majority of muscles (neck, shoulder, back, thigh) but Tibialis Anterior (foot lever muscle) stiffness decreased inflight vs. preflight (p < 0.0001; mean difference 149 N/m) in all 12 crewmembers. The calf muscles showed opposing effects, Gastrocnemius increasing in stiffness Soleus decreasing. Selective stiffness decrements indicate lack of preservation despite daily inflight countermeasures. This calls for more targeted exercises for lower leg muscles with vital roles as ankle joint stabilizers and in gait. Muscle stiffness is a digital biomarker for risk monitoring during future planetary explorations (Moon, Mars), for healthcare management in challenging environments or clinical disorders in people on Earth, to enable effective tailored exercise programmes. KW - Ageing KW - Anatomy KW - Muscle KW - Musculoskeletal system KW - Physiology Y1 - 2024 U6 - https://doi.org/10.1038/s41598-024-54759-6 SN - 2045-2322 N1 - Corresponding author: Dieter Blottner VL - 14 IS - Article number: 4196 PB - Springer Nature CY - London ER - TY - CHAP A1 - Schneider, Dominik A1 - Wisselink, Frank A1 - Czarnecki, Christian A1 - Nölle, Nikolai T1 - Benefits and framework conditions for information-driven business models concerning the Internet of Things T2 - Digitalization in companies N2 - In the context of the increasing digitalization, the Internet of Things (IoT) is seen as a technological driver through which completely new business models can emerge in the interaction of different players. Identified key players include traditional industrial companies, municipalities and telecommunications companies. The latter, by providing connectivity, ensure that small devices with tiny batteries can be connected almost anywhere and directly to the Internet. There are already many IoT use cases on the market that provide simplification for end users, such as Philips Hue Tap. In addition to business models based on connectivity, there is great potential for information-driven business models that can support or enhance existing business models. One example is the IoT use case Park and Joy, which uses sensors to connect parking spaces and inform drivers about available parking spaces in real time. Information-driven business models can be based on data generated in IoT use cases. For example, a telecommunications company can add value by deriving more decision-relevant information – called insights – from data that is used to increase decision agility. In addition, insights can be monetized. The monetization of insights can only be sustainable, if careful attention is taken and frameworks are considered. In this chapter, the concept of information-driven business models is explained and illustrated with the concrete use case Park and Joy. In addition, the benefits, risks and framework conditions are discussed. Y1 - 2024 SN - 978-3-658-39093-8 (Print) SN - 978-3-658-39094-5 (eBook) U6 - https://doi.org/10.1007/978-3-658-39094-5_5 SP - 59 EP - 75 PB - Springer CY - Wiesbaden ER - TY - CHAP A1 - Hoffschmidt, Bernhard A1 - Alexopoulos, Spiros T1 - Perspektiven für Solarthermische Kraftwerke im Sonnengürtel T2 - Energiewende : Aspekte, Optionen, Herausforderungen : Vorträge auf der DPG-Frühjahrstagung Arbeitskreis Energie in der Deutschen Physikalischen Gesellschaft Berlin, 26. bis 28. März 2012 / hrsg. von Hardo Bruhns Y1 - 2012 SP - 81 EP - 93 PB - DPG CY - Baf Honnef ER - TY - JOUR A1 - Polen, T. A1 - Krämer, Marco A1 - Bongaerts, Johannes A1 - Wubbolts, Marcel A1 - Wendisch, V. F. T1 - The global gene expression response of Escherichia coli to L-phenylalanine JF - Journal of biotechnology Y1 - 2005 SN - 1873-4863 (E-Journal); 0168-1656 (Print) VL - Vol. 115 IS - Iss. 3 SP - 221 EP - 237 ER - TY - JOUR A1 - Bongaerts, Johannes A1 - Krämer, Marco A1 - Müller, Ulrike A1 - Raeven, Leon A1 - Wubbolts, Marcel T1 - Metabolic engineering for microbial production of aromatic amino acids and derived compounds JF - Metabolic engineering Y1 - 2001 SN - 1096-7184 (E-Journal); 1096-7176 (Print) VL - Vol. 3 IS - Iss. 4 SP - 289 EP - 300 ER - TY - THES A1 - Bung, Daniel Bernhard T1 - Imaging techniques for investigation of free-surface flows in hydraulic laboratories N2 - This thesis aims at the presentation and discussion of well-accepted and new imaging techniques applied to different types of flow in common hydraulic engineering environments. All studies are conducted in laboratory conditions and focus on flow depth and velocity measurements. Investigated flows cover a wide range of complexity, e.g. propagation of waves, dam-break flows, slightly and fully aerated spillway flows as well as highly turbulent hydraulic jumps. Newimagingmethods are compared to different types of sensorswhich are frequently employed in contemporary laboratory studies. This classical instrumentation as well as the general concept of hydraulic modeling is introduced to give an overview on experimental methods. Flow depths are commonly measured by means of ultrasonic sensors, also known as acoustic displacement sensors. These sensors may provide accurate data with high sample rates in case of simple flow conditions, e.g. low-turbulent clear water flows. However, with increasing turbulence, higher uncertainty must be considered. Moreover, ultrasonic sensors can provide point data only, while the relatively large acoustic beam footprint may lead to another source of uncertainty in case of relatively short, highly turbulent surface fluctuations (ripples) or free-surface air-water flows. Analysis of turbulent length and time scales of surface fluctuations from point measurements is also difficult. Imaging techniques with different dimensionality, however, may close this gap. It is shown in this thesis that edge detection methods (known from computer vision) may be used for two-dimensional free-surface extraction (i.e. from images taken through transparant sidewalls in laboratory flumes). Another opportunity in hydraulic laboratory studies comes with the application of stereo vision. Low-cost RGB-D sensors can be used to gather instantaneous, three-dimensional free-surface elevations, even in flows with very high complexity (e.g. aerated hydraulic jumps). It will be shown that the uncertainty of these methods is of similar order as for classical instruments. Particle Image Velocimetry (PIV) is a well-accepted and widespread imaging technique for velocity determination in laboratory conditions. In combination with high-speed cameras, PIV can give time-resolved velocity fields in 2D/3D or even as volumetric flow fields. PIV is based on a cross-correlation technique applied to small subimages of seeded flows. The minimum size of these subimages defines the maximum spatial resolution of resulting velocity fields. A derivative of PIV for aerated flows is also available, i.e. the so-called Bubble Image Velocimetry (BIV). This thesis emphasizes the capacities and limitations of both methods, using relatively simple setups with halogen and LED illuminations. It will be demonstrated that PIV/BIV images may also be processed by means of Optical Flow (OF) techniques. OF is another method originating from the computer vision discipline, based on the assumption of image brightness conservation within a sequence of images. The Horn-Schunck approach, which has been first employed to hydraulic engineering problems in the studies presented herein, yields dense velocity fields, i.e. pixelwise velocity data. As discussed hereinafter, the accuracy of OF competes well with PIV for clear-water flows and even improves results (compared to BIV) for aerated flow conditions. In order to independently benchmark the OF approach, synthetic images with defined turbulence intensitiy are used. Computer vision offers new opportunities that may help to improve the understanding of fluid mechanics and fluid-structure interactions in laboratory investigations. In prototype environments, it can be employed for obstacle detection (e.g. identification of potential fish migration corridors) and recognition (e.g. fish species for monitoring in a fishway) or surface reconstruction (e.g. inspection of hydraulic structures). It can thus be expected that applications to hydraulic engineering problems will develop rapidly in near future. Current methods have not been developed for fluids in motion. Systematic future developments are needed to improve the results in such difficult conditions. Y1 - 2023 U6 - https://doi.org/10.25926/BUW/0-172 ER - TY - CHAP A1 - Butenweg, Christoph A1 - Marinković, Marko A1 - Pavese, Alberto A1 - Lanese, Igor A1 - Hoffmeister, Benno A1 - Pinkawa, Marius A1 - Vulcu, Mihai-Cristian A1 - Bursi, Oreste A1 - Nardin, Chiara A1 - Paolacci, Fabrizio A1 - Quinci, Gianluca A1 - Fragiadakis, Michalis A1 - Weber, Felix A1 - Huber, Peter A1 - Renault, Philippe A1 - Gündel, Max A1 - Dyke, Shirley A1 - Ciucci, M. A1 - Marino, A. T1 - Seismic performance of multi-component systems in special risk industrial facilities T2 - Proceedings of the seventeenth world conference on earthquake engineering N2 - Past earthquakes demonstrated the high vulnerability of industrial facilities equipped with complex process technologies leading to serious damage of the process equipment and multiple and simultaneous release of hazardous substances in industrial facilities. Nevertheless, the design of industrial plants is inadequately described in recent codes and guidelines, as they do not consider the dynamic interaction between the structure and the installations and thus the effect of seismic response of the installations on the response of the structure and vice versa. The current code-based approach for the seismic design of industrial facilities is considered not enough for ensure proper safety conditions against exceptional event entailing loss of content and related consequences. Accordingly, SPIF project (Seismic Performance of Multi- Component Systems in Special Risk Industrial Facilities) was proposed within the framework of the European H2020 - SERA funding scheme (Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe). The objective of the SPIF project is the investigation of the seismic behavior of a representative industrial structure equipped with complex process technology by means of shaking table tests. The test structure is a three-story moment resisting steel frame with vertical and horizontal vessels and cabinets, arranged on the three levels and connected by pipes. The dynamic behavior of the test structure and installations is investigated with and without base isolation. Furthermore, both firmly anchored and isolated components are taken into account to compare their dynamic behavior and interactions with each other. Artificial and synthetic ground motions are applied to study the seismic response at different PGA levels. After each test, dynamic identification measurements are carried out to characterize the system condition. The contribution presents the numerical simulations to calibrate the tests on the prototype, the experimental setup of the investigated structure and installations, selected measurement data and finally describes preliminary experimental results. KW - industrial facilities KW - piping KW - installations KW - seismic loading KW - earthquakes Y1 - 2021 N1 - 17. World Conference on Earthquake Engineering, 17WCEE, Sendai, Japan, 2021-09-27 - 2021-10-02 ER - TY - INPR A1 - Ringers, Christa A1 - Bialonski, Stephan A1 - Solovev, Anton A1 - Hansen, Jan N. A1 - Ege, Mert A1 - Friedrich, Benjamin M. A1 - Jurisch-Yaksi, Nathalie T1 - Preprint: Local synchronization of cilia and tissue-scale cilia alignment are sufficient for global metachronal waves T2 - bioRxiv N2 - Motile cilia are hair-like cell extensions present in multiple organs of the body. How cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine here experiments, novel analysis tools, and theory to address this knowledge gap. We investigate collective dynamics of cilia in the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Despite the fact that synchronization is local only, we observed global patterns of traveling metachronal waves across the multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right nose, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment are sufficient to generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping. Y1 - 2021 U6 - https://doi.org/10.1101/2021.11.23.469646 N1 - Veröffentlicht in eLife 12:e77701 (https://doi.org/10.7554/eLife.77701). ER - TY - JOUR A1 - Abbas, Karim A1 - Balc, Nicolae A1 - Bremen, Sebastian A1 - Skupin, Marco T1 - Crystallization and aging behavior of polyetheretherketone PEEK within rapid tooling and rubber molding JF - Journal of Manufacturing and Materials Processing N2 - In times of short product life cycles, additive manufacturing and rapid tooling are important methods to make tool development and manufacturing more efficient. High-performance polymers are the key to mold production for prototypes and small series. However, the high temperatures during vulcanization injection molding cause thermal aging and can impair service life. The extent to which the thermal stress over the entire process chain stresses the material and whether it leads to irreversible material aging is evaluated. To this end, a mold made of PEEK is fabricated using fused filament fabrication and examined for its potential application. The mold is heated to 200 ◦C, filled with rubber, and cured. A differential scanning calorimetry analysis of each process step illustrates the crystallization behavior and first indicates the material resistance. It shows distinct cold crystallization regions at a build chamber temperature of 90 ◦C. At an ambient temperature above Tg, crystallization of 30% is achieved, and cold crystallization no longer occurs. Additional tensile tests show a decrease in tensile strength after ten days of thermal aging. The steady decrease in recrystallization temperature indicates degradation of the additives. However, the tensile tests reveal steady embrittlement of the material due to increasing crosslinking. KW - additive manufacturing KW - fused filament fabrication KW - crystallization KW - polyetheretherketone KW - rapid tooling Y1 - 2022 U6 - https://doi.org/10.3390/jmmp6050093 SN - 2504-4494 N1 - The article belongs to the Special Issue Advances in Injection Molding: Process, Materials and Applications VL - 6 IS - 5 SP - 1 EP - 12 PB - MDPI CY - Basel ER -