TY  - JOUR
A1  - Artmann, Gerhard
A1  - Bäumler, H.
A1  - Voigt, A.
A1  - Mitlöhner, R. [u.a.]
T1  - Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. Bäumler, H., Artmann, Gerhard Michael; Voigt, A., Mitlöhner, R., Neu, B., Kiesewetter, H.
JF  - Journal of Microencapsulation. 17 (2000), H. 5
Y1  - 2000
SN  - 1464-5246
SP  - 651
EP  - 655
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Burns, Laura
A1  - Canaves, Jaume M.
A1  - Temiz Artmann, Aysegül
T1  - Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature
JF  - European Biophysics Journal. 33 (2004), H. 6
Y1  - 2004
SN  - 1432-1017
SP  - 490
EP  - 496
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - A microscopic photometric method for measuring erythrocyte deformability. Artmann, Gerhard Michael
JF  - Clinical Hemorheology. 6 (1986)
Y1  - 1986
SN  - 0271-5198
SP  - 617
EP  - 627
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - 2nd International Conference on Medical Biorheology (ICMB). Shanghai, China, September 13-15, 1995. Shi, Young de, Artmann, Gerhard Michael, Meiselman, Herbert J.
JF  - Biorheology. 33 (1996), H. 6
Y1  - 1996
SN  - 0006-355x
SP  - 505
EP  - 507
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - Microscopic photometric quantification of stiffness and relaxation time of red blood cells in a flow chamber. Artmann, Gerhard Michael
JF  - Biorheology. 32 (1995), H. 5
Y1  - 1995
SN  - 0006-355x
SP  - 553
EP  - 570
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - Cellular engineering - a challenge for engineers? / Artmann, G. M.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 449
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Oberländer, Jan
A1  - Mätzkow, M.
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Surface functionalization for spore-based biosensors with organosilanes
JF  - Electrochimica Acta
N2  - In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated.
Y1  - 2017
U6  - https://doi.org/10.1016/j.electacta.2017.04.157
SN  - 0013-4686
VL  - 241
SP  - 237
EP  - 243
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Mätzkow, Malte
A1  - Durán, Marlena Palomar
A1  - Greeff, Anton
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Optimization of the immobilization of bacterial spores on glass substrates with organosilanes
JF  - Physica status solidi (A) : Applications and materials science
N2  - Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication.
KW  - silanization
KW  - organosilanes
KW  - immobilization
KW  - endospores
KW  - biosensors
KW  - Bacillus atrophaeus
Y1  - 2016
U6  - https://doi.org/10.1002/pssa.201532914
SN  - 1862-6319
VL  - 213
IS  - 6
SP  - 1463
EP  - 1470
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Combined calorimetric gas- and spore-based biosensor array for online monitoring and sterility assurance of gaseous hydrogen peroxide in aseptic filling machines
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2019.111628
SN  - 0956-5663
VL  - 143
IS  - 111628
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Toward an immobilization method for spore-based biosensors in oxidative environment
JF  - Electrochimica Acta
Y1  - 2019
U6  - https://doi.org/10.1016/j.electacta.2019.01.148
VL  - 302
SP  - 394
EP  - 401
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Effect of O2 plasma on properties of electrolyte-insulator-semiconductor structures
JF  - physica status solidi a : applications and materials sciences
N2  - Prior to immobilization of biomolecules or cells onto biosensor surfaces, the surface must be physically or chemically activated for further functionalization. Organosilanes are a versatile option as they facilitate the immobilization through their terminal groups and also display self-assembly. Incorporating hydroxyl groups is one of the important methods for primary immobilization. This can be done, for example, with oxygen plasma treatment. However, this treatment can affect the performance of the biosensors and this effect is not quite well understood for surface functionalization. In this work, the effect of O2 plasma treatment on EIS sensors was investigated by means of electrochemical characterizations: capacitance–voltage (C–V) and constant capacitance (ConCap) measurements. After O2 plasma treatment, the potential of the EIS sensor dramatically shifts to a more negative value. This was successfully reset by using an annealing process.
KW  - surface functionalization
KW  - O2 plasma
KW  - hydroxylation
KW  - electrolyte-insulator semiconductor sensor (EIS)
KW  - annealing
Y1  - 2017
U6  - https://doi.org/10.1002/pssa.201700025
SN  - 1862-6319
VL  - 214
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Arpshofen, Ingo
A1  - Pool, M. J.
A1  - Sommer, Ferdinand
A1  - Gerling, Ulrich
A1  - Predel, Bruno
A1  - Schultheiss, Emil
T1  - Determination of the integral mixing enthalpies in the Cu-Pd-Si liquid ternary alloy system at 1600 K
JF  - Zeitschrift für Metallkunde : international journal of materials research and advanced techniques. Bd. 74, H. 1
Y1  - 1983
SN  - 0044-3093 ; 0179-4841
SP  - 25
EP  - 32
ER  - 
TY  - JOUR
A1  - Arpshofen, Ingo
A1  - Gerling, Ulrich
A1  - Sommer, Ferdinand
A1  - Schultheiss, Emil
A1  - Predel, Bruno
A1  - Pool, M. J.
T1  - Experimentelle Bestimmung der integralen Mischungsenthalpien in den binären Systemen Pd-Cu und Si-Cu bei 1600 K
JF  - Zeitschrift für Metallkunde : international journal of materials research and advanced techniques. Bd. 72, H. 12
Y1  - 1981
SN  - 0044-3093 ; 0179-4841
SP  - 842
EP  - 846
ER  - 
TY  - JOUR
A1  - Arpshofen, Ingo
A1  - Gerling, Ulrich
A1  - Sommer, Ferdinand
A1  - Schultheiss, Emil
A1  - Predel, Bruno
A1  - Pool, M. J.
T1  - Bestimmung der Mischungsenthalpien im System Palladium-Silicium bei 1600 K
JF  - Zeitschrift für Metallkunde : international journal of materials research and advanced techniques. Bd. 72, H. 11
Y1  - 1981
SN  - 0044-3093 ; 0179-4841
SP  - 776
EP  - 781
ER  - 
TY  - JOUR
A1  - Arinkin, Vladimir
A1  - Digel, Ilya
A1  - Porst, Dariusz
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application
JF  - BMC bioinformatics
N2  - Background
True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN).

Results
Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm.

Conclusions
Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1% and reached 100% in one of the best ANN.
Y1  - 2014
U6  - https://doi.org/10.1186/1471-2105-15-55
SN  - 1471-2105
VL  - 15
IS  - 55
SP  - 1
EP  - 8
ER  - 
TY  - JOUR
A1  - Arida, Hassan
A1  - Turek, Monika
A1  - Rolka, David
A1  - Schöning, Michael Josef
T1  - A Novel Thin-Film Copper Array Based on an Organic/Inorganic Sensor Hybrid: Microfabrication, Potentiometric Characterization, and Flow-Injection Analysis Application
JF  - Electroanalysis. 21 (2009), H. 10
Y1  - 2009
SN  - 1040-0397
SP  - 1145
EP  - 1151
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Arida, Hassan
A1  - Mohsen, Q.
A1  - Schöning, Michael Josef
T1  - Microfabrication, characterization and analytical application of a new thin-film silver microsensor
JF  - Electrochimica Acta. 54 (2009), H. 13
Y1  - 2009
SN  - 0013-4686
SP  - 3543
EP  - 3547
ER  - 
TY  - JOUR
A1  - Arida, Hassan A.
A1  - Al-haddad, Ameera
A1  - Schöning, Michael Josef
T1  - New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode
JF  - International Journal of Electrochemical Science. 6 (2011), H. 9
Y1  - 2011
SN  - 1452-3981
SP  - 3858
EP  - 3867
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Peper, Andreas
A1  - Bierbaum, Stefanie
A1  - Albracht, Kirsten
T1  - Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain
JF  - Journal of Biomechanics
N2  - The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47%), and the other leg at high tendon strain magnitude (4.72±1.08%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon–aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon–aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.
Y1  - 2010
U6  - https://doi.org/10.1016/j.jbiomech.2010.08.014
SN  - 0021-9290
VL  - 43
IS  - 16
SP  - 3073
EP  - 3079
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Karamanidis, Kiros
A1  - Mademli, Lida
A1  - Albracht, Kirsten
T1  - Plasticity of the human tendon to short and long-term mechanical loading
JF  - Exercise and Sport Sciences Reviews
Y1  - 2009
U6  - https://doi.org/10.1097/JES.0b013e31819c2e1d
SN  - 1538-3008
VL  - 37
IS  - 2
SP  - 66
EP  - 72
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Karamanidis, Kiros
A1  - Albracht, Kirsten
T1  - Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude
JF  - Journal of Experimental Biology
Y1  - 2007
U6  - https://doi.org/10.1242/jeb.003814
SN  - 0022-0949
VL  - 210
IS  - 15
SP  - 2743
EP  - 2753
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Tuelbentci, K.
T1  - Lichtbogenschweißen : Untersuchung der Schweißschlacke und der Wirkungen auf das Entfernen der Schlacke beim Lichtbogenschweißen ; Teil 1
JF  - Technische Rundschau : TR ; das Schweizer Industrie-Magazin
Y1  - 1973
SN  - 0040-148X
VL  - 65
IS  - 48
SP  - 13
EP  - 15
PB  - Medtrix Group
CY  - Basel
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Tuelbentci, K.
T1  - Lichtbogenschweißen : Untersuchung der Schweißschlacke und der Wirkungen auf das Entfernen der Schlacke ; Teil 2
JF  - Technische Rundschau : TR ; das Schweizer Industrie-Magazin
Y1  - 1973
SN  - 0040-148X
VL  - 65
IS  - 52
SP  - 9
EP  - 13
PB  - Medtrix Group
CY  - Basel
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Tuelbentci, K.
T1  - Lichtbogenschweißen : Untersuchung der Schweißschlacke und der Wirkungen auf das Entfernen der Schlacke ; Teil 3
JF  - Technische Rundschau : TR ; das Schweizer Industrie-Magazin
Y1  - 1974
SN  - 0040-148X
VL  - 66
IS  - 2
SP  - 43
EP  - 47
PB  - Medtrix Group
CY  - Basel
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Topuz, A.
A1  - Tuncel, H. S.
T1  - Einfluß der Parameter beim Diffusionsschweißen der Stähle X210Cr12 mit 25 CrMo4 auf die Ausbildung der Bindezone
JF  - Schweißen und Schneiden : Fachzeitschrift für Schweißen und verwandte Verfahren
Y1  - 1992
SN  - 0036
VL  - 44
IS  - 2
SP  - 97
EP  - 100
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Topuz, A.
A1  - Tuncel, H. S.
T1  - Einfluß der Parameter beim Diffusionsschweißen der Stähle X 210 Cr 12 und 25 MoCr 4 auf ihre mechanischen Eigenschaften
JF  - Schweißen und Schneiden : Fachzeitschrift für Schweißen und verwandte Verfahren
Y1  - 1991
SN  - 0036-7184
VL  - 43
IS  - 6
SP  - 341
EP  - 344
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Kapoor, Madan Lal
A1  - Frohberg, Martin G.
T1  - Thermodynamic behaviour of oxygen in molten substitutional alloy solvents
JF  - Zeitschrift für Metallkunde
Y1  - 1983
SN  - 0044-3093
VL  - 74
IS  - 1
SP  - 53
EP  - 58
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
A1  - Kapoor, Madan Lal
T1  - Untersuchungen zum thermodynamischen Verhalten des Sauerstoffs in Kupfer-Wismut-Schmelzen bei 1200°C
JF  - Zeitschrift für Physikalische Chemie
Y1  - 1982
SN  - 0942-9352
VL  - 133
IS  - 2
SP  - 167
EP  - 174
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
A1  - Kapoor, Madan Lal
T1  - Experiments and theoretical considerations on the solution of oxygen in binary metal alloys
JF  - Berichte der Bunsengesellschaft für physikalische Chemie
Y1  - 1983
SN  - 0005-9021
SN  - 0940-483X
VL  - 87
IS  - 12
SP  - 1201
EP  - 1204
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
A1  - Kapoor, Madan Lal
T1  - Prediction of thermodynamic properties of oxygen in binary metallic solvents
JF  - Zeitschrift für Metallkunde
Y1  - 1983
SN  - 0044-3093
VL  - 74
IS  - 6
SP  - 372
EP  - 375
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
T1  - Thermodynamics and solubility of oxygen in liquid copper-lead alloys at 1200°C from E.M.F. measurements
JF  - Berichte der Bunsengesellschaft für physikalische Chemie
Y1  - 1984
SN  - 0940-483X
SN  - 0005-9021
VL  - 88
IS  - 8
SP  - 707
EP  - 710
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
T1  - Thermodynamics and solubility of oxygen in liquid bismuth-lead and bismuth-antimony alloys
JF  - Berichte der Bunsengesellschaft für physikalische Chemie
Y1  - 1987
SN  - 0940-483X
SN  - 0005-9021
VL  - 91
IS  - 7
SP  - 790
EP  - 794
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
T1  - Investigations of the thermodynamics of oxygen and the determination of the miscibility gap in the system copper-oxygen-lead at 12000C
JF  - Zeitschrift für Metallkunde
Y1  - 1984
SN  - 0044-3093
VL  - 75
IS  - 8
SP  - 586
EP  - 589
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
T1  - Investigation of the thermodynamics of oxygen and the determination of phase boundaries in the system copper-oxygen-bismuth at 12000C
JF  - Zeitschrift für Metallkunde
Y1  - 1983
SN  - 0044-3093
VL  - 74
IS  - 8
SP  - 530
EP  - 534
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
T1  - Thermodynamics of oxygen in the copper-antimony system at 1473K
JF  - Erzmetall : Rohstoffgewinnung, Verarbeitung, Recycling, Umwelttechnik
Y1  - 1988
SN  - 0044-2658
VL  - 41
IS  - 10
SP  - 498
EP  - 501
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Dagsoez, A. K.
T1  - Feinbleche schweißen : die Temperaturverteilung in dünnen Stahlblechplatten beim Lichtbogenschweißen
JF  - Technische Rundschau : TR ; das Schweizer Industrie-Magazin
Y1  - 1971
SN  - 0040-148X
VL  - 63
IS  - 9
SP  - 57
EP  - 59
PB  - Medtrix Group
CY  - Basel
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Anik, Salahaddin
T1  - Stand der Schweißtechnik in der Türkei
JF  - Schweißen und Schneiden : Fachzeitschrift für Schweißen und verwandte Verfahren
Y1  - 1991
SN  - 0036-7184
VL  - 43
IS  - 3
SP  - 142
EP  - 145
ER  - 
TY  - JOUR
A1  - Anik, Sabri
T1  - Gespritzte Metallbeschichtungen : Eigenschaften lichtbogengespritzter Stahlschichten in Abhängigkeit von einigen Spritzparametern
JF  - Technische Rundschau : TR ; das Schweizer Industrie-Magazin
Y1  - 1978
SN  - 0040-148X
VL  - 70
IS  - 26
SP  - 9
EP  - 13
PB  - Medtrix Group
CY  - Basel
ER  - 
TY  - JOUR
A1  - Anik, Sabri
T1  - Gespritzte Metallschichten : Eigenschaften lichtbogengespritzter Stahlschichten in Abhängigkeit von einigen Spritzparametern
JF  - Technische Rundschau : TR ; das Schweizer Industrie-Magazin
Y1  - 1978
SN  - 0040-148X
VL  - 70
IS  - 39
SP  - 37
EP  - 41
PB  - Medtrix Group
CY  - Basel
ER  - 
TY  - JOUR
A1  - Angermann, Susanne
A1  - Günthner, Roman
A1  - Hanssen, Henner
A1  - Lorenz, Georg
A1  - Braunisch, Matthias C.
A1  - Steubl, Dominik
A1  - Matschkal, Julia
A1  - Kemmner, Stephan
A1  - Hausinger, Renate
A1  - Block, Zenonas
A1  - Haller, Bernhard
A1  - Heemann, Uwe
A1  - Kotliar, Konstantin
A1  - Grimmer, Timo
A1  - Schmaderer, Christoph
T1  - Cognitive impairment and microvascular function in end-stage renal disease
JF  - International Journal of Methods in Psychiatric Research (MPR)
N2  - Objective
Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels.

Methods
152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions.

Results
In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained.

Conclusion
This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.
KW  - cerebral small vessel disease
KW  - cognitive impairment
KW  - dialysis
KW  - retinal vessels
Y1  - 2022
U6  - https://doi.org/10.1002/mpr.1909
SN  - 1049-8931 (Print)
SN  - 1557-0657 (Online)
VL  - 31
IS  - 2
SP  - 1
EP  - 10
PB  - Wiley
ER  - 
TY  - JOUR
A1  - Anding, Ralf
A1  - Tabaza, Ruth
A1  - Staat, Manfred
A1  - Trenz, Eva
A1  - Lohmann, Philipp
A1  - Klinge, Uwe
A1  - Kirschner-Hermanns, Ruth
T1  - Introducing a method of in vitro testing of different anchoring systems used for female incontinence and prolapse surgery
JF  - BioMed research international
Y1  - 2013
SN  - 1110-7251 (E-Journal); 2314-6141 (E-Journal); 1110-7243 (Print); 2314-6133 (Print)
VL  - Vol. 2013
SP  - Article ID 401417
ER  - 
TY  - JOUR
A1  - Amin, Rashid
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Lazarovici, Philip
A1  - Lelkes, Peter I.
T1  - Permeability of an In Vitro Model of Blood Brain Barrier (BBB)
JF  - 13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]
Y1  - 2009
SN  - 978-3-540-92841-6
N1  - IFMBE Proceedings ; 23, Track 1 ; ICBME 2008 3–6 December 2008 Singapore
SP  - 81
EP  - 84
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Leise, Philipp
A1  - Pfetsch, Marc E.
A1  - Schmitt, Andreas
T1  - Algorithmic design and resilience assessment of energy efficient high-rise water supply systems
JF  - Applied Mechanics and Materials
N2  - High-rise water supply systems provide water flow and suitable pressure in all levels of tall buildings. To design such state-of-the-art systems, the consideration of energy efficiency and the anticipation of component failures are mandatory. In this paper, we use Mixed-Integer Nonlinear Programming to compute an optimal placement of pipes and pumps, as well as an optimal control strategy.Moreover, we consider the resilience of the system to pump failures. A resilient system is able to fulfill a predefined minimum functionality even though components fail or are restricted in their normal usage. We present models to measure and optimize the resilience. To demonstrate our approach, we design and analyze an optimal resilient decentralized water supply system inspired by a real-life hotel building.
KW  - MINLP
KW  - Buffering Capacity
KW  - Uncertainty
KW  - Water Supply Networks
KW  - Booster Stations
Y1  - 2018
U6  - https://doi.org/10.4028/www.scientific.net/AMM.885.211
SN  - 1662-7482
VL  - 885
SP  - 211
EP  - 223
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Joggerst, Laura
A1  - Leise, Philipp
A1  - Pfetsch, Marc E.
A1  - Schmitt, Andreas
A1  - Wendt, Janine
T1  - On obligations in the development process of resilient systems with algorithmic design methods
JF  - Applied Mechanics and Materials
N2  - Advanced computational methods are needed both for the design of large systems and to compute high accuracy solutions. Such methods are efficient in computation, but the validation of results is very complex, and highly skilled auditors are needed to verify them. We investigate legal questions concerning obligations in the development phase, especially for technical systems developed using advanced methods. In particular, we consider methods of resilient and robust optimization. With these techniques, high performance solutions can be found, despite a high variety of input parameters. However, given the novelty of these methods, it is uncertain whether legal obligations are being met. The aim of this paper is to discuss if and how the choice of a specific computational method affects the developer’s product liability. The review of legal obligations in this paper is based on German law and focuses on the requirements that must be met during the design and development process.
KW  - legal obligations
KW  - product liability
KW  - design of technical systems
KW  - optimization
KW  - resilience
Y1  - 2018
SN  - 1662-7482
U6  - https://doi.org/10.4028/www.scientific.net/AMM.885.240
VL  - 885
IS  - 885
SP  - 240
EP  - 252
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Ederer, Thorsten
A1  - Pöttgen, Philipp
A1  - Lorenz, Ulf
A1  - Pelz, Peter F.
ED  - Pelz, Peter F.
ED  - Groche, Peter
T1  - Multicriterial optimization of technical systems considering multiple load and availability scenarios
JF  - Applied Mechanics and Materials
N2  - Cheap does not imply cost-effective -- this is rule number one of zeitgeisty system design. The initial investment accounts only for a small portion of the lifecycle costs of a technical system. In fluid systems, about ninety percent of the total costs are caused by other factors like power consumption and maintenance. With modern optimization methods, it is already possible to plan an optimal technical system considering multiple objectives. In this paper, we focus on an often neglected contribution to the lifecycle costs: downtime costs due to spontaneous failures. Consequently, availability becomes an issue.
KW  - sustainability
KW  - availability
KW  - energy efficiency
KW  - mixed-integer linear programming
KW  - system synthesis
Y1  - 2015
SN  - 1660-9336
U6  - https://doi.org/10.4028/www.scientific.net/AMM.807.247
VL  - 807
SP  - 247
EP  - 256
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Ederer, Thorsten
A1  - Pfetsch, Marc E.
A1  - Pelz, Peter F.
T1  - Maschinelles Design eines optimalen Getriebes
JF  - ATZ - Automobiltechnische Zeitschrift
N2  - Nahezu 100.000 denkbare Strukturen kann ein Getriebe bei gleicher Funktion aufweisen - je nach Ganganzahl und gefordertem Freiheitsgrad. Mit dem traditionellen Ansatz bei der Entwicklung, einzelne vielversprechende Systemkonfigurationen manuell zu identifizieren und zu vergleichen, können leicht innovative und vor allem kostenminimale Lösungen übersehen werden. Im Rahmen eines Forschungsprojekts hat die TU Darmstadt spezielle Optimierungsmethoden angewendet, um auch bei großen Lösungsräumen zielsicher ein für die individuellen Zielstellungen optimales Layout zu finden.
Y1  - 2018
SN  - 2192-8800
U6  - https://doi.org/10.1007/s35148-018-0131-3
VL  - 120
IS  - 10
SP  - 72
EP  - 77
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Ederer, Thorsten
A1  - Lorenz, Ulf
A1  - Pelz, Peter F.
A1  - Pöttgen, Philipp
ED  - Lübbecke, Marco
ED  - Koster, Arie
ED  - Letmathe, Peter
ED  - Madlener, Reihard
ED  - Peis, Britta
ED  - Walther, Grit
T1  - Experimental validation of an enhanced system synthesis approach
JF  - Operations Research Proceedings 2014
N2  - Planning the layout and operation of a technical system is a common task
for an engineer. Typically, the workflow is divided into consecutive stages: First,
the engineer designs the layout of the system, with the help of his experience or of
heuristic methods. Secondly, he finds a control strategy which is often optimized
by simulation. This usually results in a good operating of an unquestioned sys-
tem topology. In contrast, we apply Operations Research (OR) methods to find a
cost-optimal solution for both stages simultaneously via mixed integer program-
ming (MILP). Technical Operations Research (TOR) allows one to find a provable
global optimal solution within the model formulation. However, the modeling error
due to the abstraction of physical reality remains unknown. We address this ubiq-
uitous problem of OR methods by comparing our computational results with mea-
surements in a test rig. For a practical test case we compute a topology and control
strategy via MILP and verify that the objectives are met up to a deviation of 8.7%.
Y1  - 2014
SN  - 978-3-319-28695-2
U6  - https://doi.org/10.1007/978-3-319-28697-6_1
PB  - Springer
CY  - Basel
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Brötz, Nicolas
A1  - Dietrich, Ingo
A1  - Gally, Tristan
A1  - Geßner, Felix
A1  - Kloberdanz, Hermann
A1  - Leise, Philipp
A1  - Pelz, Peter Franz
A1  - Schlemmer, Pia
A1  - Schmitt, Andreas
T1  - Resilience in mechanical engineering - a concept for controlling uncertainty during design, production and usage phase of load-carrying structures
JF  - Applied Mechanics and Materials
N2  - Resilience as a concept has found its way into different disciplines to describe the ability of an individual or system to withstand and adapt to changes in its environment. In this paper, we provide an overview of the concept in different communities and extend it to the area of mechanical engineering. Furthermore, we present metrics to measure resilience in technical systems and illustrate them by applying them to load-carrying structures. By giving application examples from the Collaborative Research Centre (CRC) 805, we show how the concept of resilience can be used to control uncertainty during different stages of product life.
Y1  - 2018
SN  - 1662-7482
U6  - https://doi.org/10.4028/www.scientific.net/AMM.885.187
VL  - 885
SP  - 187
EP  - 198
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - JOUR
A1  - Altay, Okyay
A1  - Butenweg, Christoph
A1  - Taddei, Francesca
T1  - Effektivität von Schwingungsdämpfern bei Windenergieanlagen
JF  - Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt
Y1  - 2013
SN  - 1436-4867 (E-Journal); 0005-6650 (Print)
N1  - Printausgabe in der Bibliothek Bayernallee vorhanden: 13 Z 049-2013
VL  - Band 88
IS  - Heft 10
SP  - S11
EP  - S17
PB  - VDI Fachmedien
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Spannungs-Blindleistungs-Regelung mit gesteuerten Netzkennlinien
JF  - Elektrotechnische Zeitschrift : Ausgabe A, Zeitschrift für elektrische Energietechnik : ETZ
Y1  - 1976
SN  - 0302-265x
VL  - 97
IS  - 7
SP  - 441
EP  - 446
PB  - VDE-Verlag
CY  - Wuppertal
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Netzanschlußmöglichkeiten und energiewirtschaftliche Bewertung von Windkraftanlagen
JF  - Elektrizitätswirtschaft
Y1  - 1995
SN  - 0013-5496
VL  - Jg. 94
IS  - H. 19
SP  - 1224
EP  - 1234
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Benchmark der Netznutzungspreise
JF  - Energiewirtschaftliche Tagesfragen : et ; Zeitschrift für Energiewirtschaft, Recht, Technik und Umwelt
Y1  - 2000
SN  - 0013-743X
VL  - Bd. 50
IS  - H. 11
SP  - 846
EP  - 850
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Die Bedeutung des Effektivzinses in der Finanzwirtschaft
JF  - Betriebs-Berater : BB : Beil. 14 Finanz-Berater
Y1  - 1989
SN  - 0340-7926
N1  - Printausg. in der Bibliothek vorhanden: 43 Z 228
SP  - 31
EP  - 32
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Einfluß der Kontoführungsmodelle auf den Effektivzins und die Restschuld bei Annuitätendarlehen
JF  - Betriebs-Berater : BB : Beil. 14 Finanz-Berater
Y1  - 1989
SN  - 0340-7926
N1  - Printausg. in der Bibliothek vorhanden: 43 Z 228
SP  - 32
EP  - 37
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Belieferung von Kunden in fremden Netzgebieten
JF  - EW : das Magazin für die Energie-Wirtschaft
Y1  - 2002
SN  - 0013-5496
N1  - Printausg. in der Bibliothek vorhanden: 23 Z 585
VL  - Bd. 101
IS  - H. 1/2
SP  - 26
EP  - 35
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Wunschphantasie eines eingefleischten Kernenergiegegners : zur Rede von Bundesumweltminister Jürgen Trittin auf dem VDEW-Kongress 2005 "Die Energieversorgung der Zukunft"
JF  - EW : das Magazin für die Energie-Wirtschaft
Y1  - 2005
SN  - 0013-5496
N1  - Printausg. in der Bibliothek vorhanden: 23 Z 585
VL  - Bd. 104
IS  - H. 17/18
SP  - 7
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Versorgungssicherheit und Windenergie : Tatsachen und Fakten statt Mythen und Mysterien
JF  - EW : das Magazin für die Energie-Wirtschaft
Y1  - 2005
SN  - 0013-5496
N1  - Printaus. in der Bibliothek vorhanden: 23 Z 585
VL  - Bd. 104
IS  - H. 25
SP  - 42
EP  - 45
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Die Sonne bestimmt zunehmend die Spannung in der Steckdose : Lastflussberechnung einer Photovoltaikeinspeisung
JF  - EW : das Magazin für die Energie-Wirtschaft
Y1  - 2011
SN  - 0013-5496
N1  - Printausg. in der Bibliothek vorhanden: 23 Z 585
VL  - Bd. 110
IS  - H. 17/18
SP  - 24
EP  - 29
PB  - VWEW-Energieverlag
CY  - Frankfurt, M.
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Entwicklungstendenzen der Sicherheit und der notwendigen Reserveleistung beim Verbundbetrieb der Kraftwerke
JF  - Elektrizitätswirtschaft
Y1  - 1970
SN  - 0013-5496
VL  - 69
IS  - 25
SP  - 672
EP  - 678
PB  - VWEW-Energieverlag
CY  - Frankfurt/Main
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Digitale Berechnung der Betriebsdiagramme von Hochspannungsleitungen
JF  - Elektrizitätswirtschaft
Y1  - 1972
SN  - 0013-5496
VL  - 71
IS  - 4
SP  - 87
EP  - 92
PB  - VWEW-Energieverlag
CY  - Frankfurt/Main
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Auswertung von Prüfungsergebnissen auf elektronischen Rechenanlagen
JF  - Angewandte Informatik
Y1  - 1974
SN  - 0013-5704
VL  - 16
IS  - 5
SP  - 219
EP  - 222
PB  - Vieweg
CY  - Braunschweig
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Tabellenfreie Berechnung der Einkommensteuer mit Hilfe des programmierbaren Taschenrechners
JF  - Elektrizitätswirtschaft
Y1  - 1978
SN  - 0013-5496
VL  - 77
SP  - 486
EP  - 489
PB  - VWEW-Energieverlag
CY  - Frankfurt/Main
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Wirtschaftlichkeit von Investitionen
JF  - Elektrizitätswirtschaft
Y1  - 1978
SN  - 0013-5496
VL  - 77
IS  - 3
SP  - 73
EP  - 76
PB  - VWEW-Energieverlag
CY  - Frankfurt/Main
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Isolierte Freileitungen, ein Betriebsmittel für schwierige Trassenführung
JF  - Elektrizitätswirtschaft
Y1  - 1979
SN  - 0013-5496
VL  - Jg. 78
IS  - H. 10
SP  - 250
EP  - 256
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Kurzschlußstromberechnung
JF  - Elektrizitätswirtschaft
Y1  - 1980
SN  - 0013-5496
VL  - Jg. 79
IS  - H. 10
SP  - 379
EP  - 382
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Wirtschaftlichkeitsberechnung von Investitionen mit dem programmierbaren Taschenrechner
JF  - 3 R international : RRR ; Rohre, Rohrleitungsbau, Rohrleitungstransport
Y1  - 1981
SN  - 0340-3386
VL  - Jg. 20
IS  - H. 10
SP  - 561
EP  - 565
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Statische oder dynamische Wirtschaftlichkeitsberechnung bei Investitionen zur Energieeinsparung
JF  - Elektrowärme international Edition B: Industrielle Elektrowärme : IEW = Industrial applications of electro-heat : EWI ; Zeitschrift für das gesamte Gebiet der Elektrowärme in Industrie, Gewerbe und Haushalt
Y1  - 1982
SN  - 0340-3521
VL  - Jg. 40
IS  - H. 3/4
SP  - 166
EP  - 172
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Einsatz programmierbarer Rechner im Sondervertragskundenbereich der Gasversorgung
JF  - Das Gas- und Wasserfach : Ausgabe Gas, Erdgas : GWF
Y1  - 1983
SN  - 0016-4909
VL  - Bd. 124
IS  - H. 9
SP  - 468
EP  - 471
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Intervallschalter mit getrennt einstellbarer Pulszeit und Pulszahl
JF  - Elektronik : Fachmedium für industrielle Anwender und Entwickler
Y1  - 1978
SN  - 0013-5658
VL  - 27
IS  - H. 14
SP  - 76
PB  - WEKA Fachmedien
CY  - Haar
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Auswertung von Belastungskennlinien
JF  - Elektrizitätswirtschaft
Y1  - 1983
SN  - 0013-5496
VL  - Bd. 82
SP  - 208
EP  - 210
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Vorteilsausgleich durch Versorgungsunternehmen für Ersatzleistungen Dritter
JF  - Elektrizitätswirtschaft
Y1  - 1985
SN  - 0013-5496
VL  - Jg. 104
SP  - 440
EP  - 443
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Multiplikativ oder additiv? Diskussionsbeitrag zu Preisanpassungsklauseln in der Gaswirtschaft
JF  - Energiewirtschaftliche Tagesfragen : et ; Zeitschrift für Energiewirtschaft, Recht, Technik und Umwelt
Y1  - 1985
SN  - 0013-743X
VL  - Jg. 35
SP  - 609
EP  - 611
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Steuersenkungsgesetz-Auswirkungen und Berechnung
JF  - Elektrizitätswirtschaft
Y1  - 1986
SN  - 0013-5496
VL  - Jg. 85
SP  - 238
EP  - 242
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Dialoggesteuerte harmonische Analyse mit dem HP 41
JF  - Elektrizitätswirtschaft
Y1  - 1986
SN  - 0013-5496
VL  - Bd. 85
IS  - H. 4
SP  - 139
EP  - 142
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Dialoggesteuerte harmonische Analyse mit dem HP 41
JF  - Elektrowärme international Edition B : Industrielle Elektrowärme : IEW = Industrial applications of electro-heat : EWI ; Zeitschr. für das gesamte Gebiet der Elektrowärme in Industrie, Gewerbe und Haushalt
Y1  - 1986
SN  - 0340-3521
VL  - Jg. 44
IS  - H. 6
SP  - 283
EP  - 287
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Dialoggesteuerte Spannungs- und Belastungsberechnung im Netz eines Elektrizitätsversorgungsunternehmens
JF  - Elektrizitätswirtschaft
Y1  - 1986
SN  - 0013-5496
VL  - Bd. 85
IS  - H. 23
SP  - 906
EP  - 910
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Effektivzinsberechnung bei industriellen oder gewerblichen Tilgungsdarlehen
JF  - Elektrizitätswirtschaft
Y1  - 1987
SN  - 0013-5496
VL  - Bd. 86
SP  - 592
EP  - 595
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Steuerreformgesetz 1990
JF  - Elektrizitätswirtschaft
Y1  - 1989
SN  - 0013-5496
VL  - Bd. 88
IS  - H. 1/2
SP  - 78
EP  - 83
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Steuersenkungs-Erweiterungsgesetz 1988 zur Gesamtentlastung der Einkommensteuer
JF  - Betriebs-Berater : BB ; Zeitschrift für Recht und Wirtschaft
Y1  - 1987
SN  - 0340-7918
VL  - Vol. 42
IS  - H. 32
SP  - 2207
EP  - 2208
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Steuerreformgesetz 1990
JF  - Elektrizitätswirtschaft
Y1  - 1989
SN  - 0947-0581 (E-Journal); 0340-7918 (Print)
VL  - Jg. 88
IS  - H. 2
SP  - 120
EP  - 121
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Energietarifstruktur in Ostdeutschland
JF  - Energiewirtschaftliche Tagesfragen : et ; Zeitschrift für Energiewirtschaft, Recht, Technik und Umwelt
Y1  - 1990
SN  - 0013-743X
VL  - Bd. 40
IS  - H. 11
SP  - 782
EP  - 788
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Effektivzins und APR
JF  - Die Bank : Zeitschrift für Bankpolitik und Bankpraxis
Y1  - 1991
SN  - 0342-3182
N1  - Printausg. in der Bibliothek vorhanden: 43 Z 227
VL  - Jg. 31
IS  - H. 4
SP  - 230
EP  - 231
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Möglichkeiten der CO2-Minderung "alternativ" betrachtet
JF  - Etz : Elektrotechnik & Automation
Y1  - 1992
SN  - 0170-1711
VL  - Bd. 113
IS  - H. 6-7
SP  - 400
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Netzimpedanz- und Oberschwingungsberechnung in Netzen der öffentlichen Stromversorgung
JF  - Elektrizitätswirtschaft
Y1  - 1995
SN  - 0013-5496
VL  - Bd. 94
IS  - H. 4
SP  - 166
EP  - 174
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - 1,45 Mrd. DM für die Kohlevergasung
JF  - Energiewirtschaftliche Tagesfragen
Y1  - 1974
SN  - 0720-6240
VL  - 24
IS  - 5
SP  - 243
EP  - 244
PB  - VDE-Verlag
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Renditevergleich zwischen Immobilien und Festverzinslichen
JF  - Die Bank
Y1  - 1992
SN  - 0342-3182
IS  - H. 2
SP  - 91
EP  - 92
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Elektro-Brikett-Zentralspeicherheizung soll die Spitzenlast der EVU schonen
JF  - Energiewirtschaftliche Tagesfragen
Y1  - 1975
SN  - 0720-6240
VL  - 25
IS  - 4
SP  - 148
EP  - 149
PB  - VDE-Verlag
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Alt, Helmut
T1  - Ab 1975 Uranerz aus Rabbit-Lake
JF  - Energiewirtschaftliche Tagesfragen
Y1  - 1974
SN  - 0720-6240
VL  - 24
IS  - 1/2
SP  - 34
PB  - VDE-Verlag
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Alnemer, Momin Sami Mohammad
A1  - Kotliar, Konstantin
A1  - Neuhaus, Valentin
A1  - Pape, Hans-Christoph
A1  - Ciritsis, Bernhard D.
T1  - Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model
JF  - Cost Effectiveness and Resource Allocation
N2  - Background
Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices.

Methods
This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare & Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results.

Results
With a 10% fracture risk reduction, model A costs between $8,850 and $46,940 per quality-adjusted life-year ($/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side’s prophylaxis, the patient’s age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between $11,000/QALY and $74,000/QALY, which is below the defined willingness to pay threshold.

Conclusion
Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.
KW  - Hip fractures
KW  - Prevention
KW  - Geriatric
KW  - Cost-effectiveness
KW  - Prophylaxis
Y1  - 2023
U6  - https://doi.org/10.1186/s12962-023-00482-4
SN  - 1478-7547
N1  - Corresponding author: Momin S. Alnemer
IS  - 21, Article number: 77
PB  - Springer Nature
ER  - 
TY  - JOUR
A1  - Almajhdi, Fahad N.
A1  - Senger, Tilo
A1  - Amer, Haitham M.
A1  - Gissmann, Lutz
A1  - Öhlschläger, Peter
T1  - Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling)
JF  - PLOS one
N2  - Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism.
Y1  - 2014
U6  - https://doi.org/10.1371/journal.pone.0113461
SN  - 1932-6203
VL  - 11
IS  - 9
PB  - PLOS
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Allefeld, Carsten
A1  - Bialonski, Stephan
T1  - Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains
JF  - Physical Review E
Y1  - 2007
U6  - https://doi.org/10.1103/PhysRevE.76.066207
SN  - 2470-0053
VL  - 76
IS  - 6
SP  - 066207
ER  - 
TY  - JOUR
A1  - Aliazizi, Fereshteh
A1  - Özsoylu, Dua
A1  - Bakhshi Sichani, Soroush
A1  - Khorshid, Mehran
A1  - Glorieux, Christ
A1  - Robbens, Johan
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
T1  - Development and Calibration of a Microfluidic, Chip-Based Sensor System for Monitoring the Physical Properties of Water Samples in Aquacultures
JF  - Micromachines
N2  - In this work, we present a compact, bifunctional chip-based sensor setup that measures the temperature and electrical conductivity of water samples, including specimens from rivers and channels, aquaculture, and the Atlantic Ocean. For conductivity measurements, we utilize the impedance amplitude recorded via interdigitated electrode structures at a single triggering frequency. The results are well in line with data obtained using a calibrated reference instrument. The new setup holds for conductivity values spanning almost two orders of magnitude (river versus ocean water) without the need for equivalent circuit modelling. Temperature measurements were performed in four-point geometry with an on-chip platinum RTD (resistance temperature detector) in the temperature range between 2 °C and 40 °C, showing no hysteresis effects between warming and cooling cycles. Although the meander was not shielded against the liquid, the temperature calibration provided equivalent results to low conductive Milli-Q and highly conductive ocean water. The sensor is therefore suitable for inline and online monitoring purposes in recirculating aquaculture systems.
KW  - chip-based sensor setup
KW  - aquaculture
KW  - microfluidics
KW  - impedance spectroscopy
KW  - thermometry
KW  - electrical conductivity of liquids
Y1  - 2024
U6  - https://doi.org/10.3390/mi15060755
SN  - 2072-666X
N1  - This article belongs to the Special Issue "Multisensor Arrays"
N1  - Corresponding author: Michael J. Schöning
VL  - 15
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Alhwarin, Faraj
A1  - Ferrein, Alexander
A1  - Scholl, Ingrid
T1  - IR stereo kinect: improving depth images by combining structured light with IR stereo
Y1  - 2014
SP  - 1
EP  - 9
ER  - 
TY  - JOUR
A1  - Alexyuk, Madina
A1  - Bogoyavlenskiy, Andrey
A1  - Alexyuk, Pavel
A1  - Moldakhanov, Yergali
A1  - Berezin, Vladimir
A1  - Digel, Ilya
T1  - Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity
JF  - MicrobiologyOpen
N2  - Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40% and 37% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before.
KW  - ecological structure
KW  - metagenomics
KW  - microbial diversity
KW  - shotgun sequencing
KW  - Small Aral Sea
Y1  - 2021
U6  - https://doi.org/10.1002/mbo3.1142
SN  - 2045-8827
N1  - Corresponding author: Ilya Digel
VL  - 10
IS  - 1
SP  - 1
EP  - 10
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Alexopoulos, Spiros
A1  - Hoffschmidt, Bernhard
T1  - Solar tower power plant in Germany and future perspectives of the development of the technology in Greece and Cyprus
JF  - Renewable Energy . 35 (2010), H. 7
Y1  - 2010
SN  - 0960-1481
SP  - 1352
EP  - 1356
ER  - 
TY  - JOUR
A1  - Alexopoulos, Spiros
A1  - Hoffschmidt, Bernhard
T1  - Solarthermische Kraftwerke mit thermischen Speichern
JF  - Chemie Ingenieur Technik. 82 (2010), H. 9
Y1  - 2010
SN  - 1522-2640
N1  - Special Issue: ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen V9.01 [Abstract des Vortrags]
SP  - 1606
EP  - 1606
ER  - 
TY  - JOUR
A1  - Alexopoulos, Spiros
A1  - Hoffschmidt, Bernhard
T1  - Advances in solar tower technology
JF  - Wiley interdisciplinary reviews : Energy and Environment : WIREs
Y1  - 2017
U6  - https://doi.org/10.1002/wene.217
SN  - 2041-840X
VL  - 6
IS  - 1
SP  - 1
EP  - 19
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Alexopoulos, Spiros
A1  - Breitbach, Gerd
A1  - Hoffschmidt, Bernhard
A1  - Stobbe, P.
T1  - Optimization of the geometry of porous SiC ceramic filtering modules using numerical methods
JF  - Developments in porous, biological and geopolymer ceramics : a collection of papers presented at the 31st International Conference on Advanced Ceramics and Composites, January 21 - 26, 2007, Daytona Beach, Florida ; [papers presented at the Symposium on Porous Ceramics: Novel Developments and Applications] / ed.: Manuel Brito ... Vol. ed.: Jonathan Salem ... The American Ceramics Society
Y1  - 2008
SN  - 9780470196403
N1  - Ceramic engineering and science proceedings ; 28,9
SP  - 95
EP  - 104
PB  - Wiley
CY  - Hoboken, NJ
ER  - 
TY  - JOUR
A1  - Alexopoulos, Spiros
A1  - Breitbach, Gerd
A1  - Hoffschmidt, Bernhard
A1  - Stobbe, P.
T1  - Computational fluid flow of porous resic ceramic filtering modules and optimization of the channel edge form geometry
JF  - Proceedings : April 14 - 18, 2008, Leipzig, Germany / hosted by VDI, Society for Chemical and Process Engineering . Vol 2
Y1  - 2008
N1  - Verein Deutscher Ingenieure ; World Filtration Congress ; (10 : ; 2008.04.14-18 : ; Leipzig) ; WFC ; (10 : ; 2008.04.14-18 : ; Leipzig)
SP  - 300
EP  - 304
PB  - Filtech Exhibitions
CY  - Meerbusch
ER  - 
TY  - JOUR
A1  - Alexopoulos, Spiros
T1  - Biogas systems: basics, biogas multifunction, principle of fermentation and hybrid application with a solar tower for the treatment of waste animal manure
JF  - Journal of Engineering Science and Technology Review
N2  - Two of the main environmental problems of today’s society are the continuously increasing production of organic wastes as well as the increase of carbon dioxide in the atmosphere and the related green house effect. A way to solve these problems is the production of biogas. Biogas is a combustible gas consisting of methane, carbon dioxide and small amounts of other gases and trace elements. Production of biogas through anaerobic digestion of animal manure and slurries as well as of a wide range of digestible organic wastes and agricultural residues, converts these substrates into electricity and heat and offers a natural fertiliser for agriculture. The microbiological process of decomposition of organic matter, in the absence of oxygen takes place in reactors, called digesters. Biogas can be used as a fuel in a gas turbine or burner and can be used in a hybrid solar tower system offering a solution for waste treatment of agricultural and animal residues. A solar tower system consists of a heliostat field, which concentrates direct solar irradiation on an open volumetric central receiver. The receiver heats up ambient air to temperatures of around 700°C. The hot air’s heat energy is transferred to a steam Rankine cycle in a heat recovery steam generator (HRSG). The steam drives a steam turbine, which in turn drives a generator for producing electricity. In order to increase the operational hours of a solar tower power plant, a heat storage system and/ or hybridization may be considered. The advantage of solar-fossil hybrid power plants, compared to solar-only systems, lies in low additional investment costs due to an adaptable solar share and reduced technical and economical risks. On sunny days the hybrid system operates in a solar-only mode with the central receiver and on cloudy days and at night with the gas turbine only. As an alternative to methane gas, environmentally neutral biogas can be used for operating the gas turbine. Hence, the hybrid system is operated to 100% from renewable energy sources
Y1  - 2012
SN  - 1791-2377
N1  - Special Issue on Renewable Energy Systems
VL  - 5
IS  - 4
SP  - 48
EP  - 55
ER  -