TY  - JOUR
A1  - Alexyuk, Madina
A1  - Bogoyavlenskiy, Andrey
A1  - Alexyuk, Pavel
A1  - Moldakhanov, Yergali
A1  - Berezin, Vladimir
A1  - Digel, Ilya
T1  - Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity
JF  - MicrobiologyOpen
N2  - Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40% and 37% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before.
KW  - ecological structure
KW  - metagenomics
KW  - microbial diversity
KW  - shotgun sequencing
KW  - Small Aral Sea
Y1  - 2021
U6  - http://dx.doi.org/10.1002/mbo3.1142
SN  - 2045-8827
VL  - 10
IS  - 1
SP  - 1
EP  - 10
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Alhaskir, Mohamed
A1  - Tschesche, Matteo
A1  - Linke, Florian
A1  - Schriewer, Elisabeth
A1  - Weber, Yvonne
A1  - Wolking, Stefan
A1  - Röhrig, Rainer
A1  - Koch, Henner
A1  - Kutafina, Ekaterina
ED  - Röhrig, Rainer
ED  - Grabe, Niels
ED  - Haag, Martin
ED  - Hübner, Ursula
ED  - Sax, Ulrich
ED  - Schmidt, Carsten Oliver
ED  - Sedlmayr, Martin
ED  - Zapf, Antonia
T1  - ECG matching: an approach to synchronize ECG datasets for data quality comparisons
T2  - German Medical Data Sciences 2023 – Science. Close to People.
N2  - Clinical assessment of newly developed sensors is important for ensuring their validity. Comparing recordings of emerging electrocardiography (ECG) systems to a reference ECG system requires accurate synchronization of data from both devices. Current methods can be inefficient and prone to errors. To address this issue, three algorithms are presented to synchronize two ECG time series from different recording systems: Binned R-peak Correlation, R-R Interval Correlation, and Average R-peak Distance. These algorithms reduce ECG data to their cyclic features, mitigating inefficiencies and minimizing discrepancies between different recording systems. We evaluate the performance of these algorithms using high-quality data and then assess their robustness after manipulating the R-peaks. Our results show that R-R Interval Correlation was the most efficient, whereas the Average R-peak Distance and Binned R-peak Correlation were more robust against noisy data.
KW  - Electrocardiography
KW  - Wearable electronic device
KW  - Sensors comparison
KW  - Time-series synchronization
Y1  - 2023
SN  - 978-1-64368-428-4 (Print)
SN  - 978-1-64368-429-1 (Online)
U6  - http://dx.doi.org/10.3233/SHTI230718
N1  - Proceedings of the 68th. Annual Meeting of the German Association of Medical Informatics, Biometry, and Epidemiology e.V. (gmds) 2023 in Heilbron, Germany

Part of the series: Studies in Health Technology and Informatics
VL  - 307
SP  - 225
EP  - 232
PB  - IOS Press
ER  - 
TY  - CHAP
A1  - Alhwarin, Faraj
A1  - Ferrein, Alexander
A1  - Gebhardt, Andreas
A1  - Kallweit, Stephan
A1  - Scholl, Ingrid
A1  - Tedjasukmana, Osmond Sanjaya
T1  - Improving additive manufacturing by image processing and robotic milling
T2  - 2015 IEEE International Conference on Automation Science and Engineering (CASE), Aug 24-28, 2015 Gothenburg, Sweden
Y1  - 2015
U6  - http://dx.doi.org/10.1109/CoASE.2015.7294217
SP  - 924
EP  - 929
ER  - 
TY  - JOUR
A1  - Alhwarin, Faraj
A1  - Ferrein, Alexander
A1  - Scholl, Ingrid
T1  - IR stereo kinect: improving depth images by combining structured light with IR stereo
Y1  - 2014
SP  - 1
EP  - 9
ER  - 
TY  - CHAP
A1  - Alhwarin, Faraj
A1  - Ferrein, Alexander
A1  - Scholl, Ingrid
T1  - IR stereo kinect: improving depth images by combining structured light with IR stereo
T2  - PRICAI 2014: Trends in artificial intelligence : 13th Pacific Rim International Conference on Artificial Intelligence : Gold Coast, QLD, Australia, December 1-5, 2014 : proceedings. (Lecture notes in computer science ; vol. 8862)
N2  - RGB-D sensors such as the Microsoft Kinect or the Asus Xtion are inexpensive 3D sensors. A depth image is computed by calculating the distortion of a known infrared light (IR) pattern which is projected into the scene. While these sensors are great devices they have some limitations. The distance they can measure is limited and they suffer from reflection problems on transparent, shiny, or very matte and absorbing objects. If more than one RGB-D camera is used the IR patterns interfere with each other. This results in a massive loss of depth information. In this paper, we present a simple and powerful method to overcome these problems. We propose a stereo RGB-D camera system which uses the pros of RGB-D cameras and combine them with the pros of stereo camera systems. The idea is to utilize the IR images of each two sensors as a stereo pair to generate a depth map. The IR patterns emitted by IR projectors are exploited here to enhance the dense stereo matching even if the observed objects or surfaces are texture-less or transparent. The resulting disparity map is then fused with the depth map offered by the RGB-D sensor to fill the regions and the holes that appear because of interference, or due to transparent or reflective objects. Our results show that the density of depth information is increased especially for transparent, shiny or matte objects.
Y1  - 2014
SN  - 978-3-319-13559-5 (Print) ; 978-3-319-13560-1 (E-Book)
U6  - http://dx.doi.org/10.1007/978-3-319-13560-1_33
SP  - 409
EP  - 421
PB  - Springer
CY  - München
ER  - 
TY  - CHAP
A1  - Alhwarin, Faraj
A1  - Ferrein, Alexander
A1  - Scholl, Ingrid
T1  - CRVM: Circular Random Variable-based Matcher - A Novel Hashing Method for Fast NN Search in High-dimensional Spaces
T2  - Proceedings of the 7th International Conference on Pattern Recognition Applications and Methods, ICPRAM 2018
Y1  - 2018
SN  - 978-989-758-276-9
U6  - http://dx.doi.org/10.5220/0006692802140221
SP  - 214
EP  - 221
ER  - 
TY  - CHAP
A1  - Alhwarin, Faraj
A1  - Ferrein, Alexander
A1  - Scholl, Ingrid
T1  - An Efficient Hashing Algorithm for NN Problem in HD Spaces
T2  - Lecture Notes in Computer Science
Y1  - 2019
SN  - 978-303005498-4
U6  - http://dx.doi.org/10.1007/978-3-030-05499-1_6
N1  - 7th International Conference on Pattern Recognition Applications and Methods, ICPRAM 2018; Funchal; Portugal; 16 January 2018 through 18 January 2018; Code 222779
SP  - 101
EP  - 115
ER  - 
TY  - CHAP
A1  - Alhwarin, Faraj
A1  - Schiffer, Stefan
A1  - Ferrein, Alexander
A1  - Scholl, Ingrid
T1  - Optimized KinectFusion Algorithm for 3D Scanning Applications
T2  - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOIMAGING
Y1  - 2018
SN  - 978-989-758-278-3
U6  - http://dx.doi.org/10.5220/0006594700500057
SP  - 50
EP  - 57
ER  - 
TY  - CHAP
A1  - Alhwarin, Faraj
A1  - Schiffer, Stefan
A1  - Ferrein, Alexander
A1  - Scholl, Ingrid
T1  - An Optimized Method for 3D Body Scanning Applications Based on KinectFusion
T2  - Communications in Computer and Information Science
Y1  - 2019
U6  - http://dx.doi.org/10.1007/978-3-030-29196-9_6
SN  - 1865-0929
N1  - 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018; Funchal; Portugal; 19 January 2018 through 21 January 2018
VL  - 1024
SP  - 100
EP  - 113
PB  - Springer
ER  - 
TY  - CHAP
A1  - Allal, D.
A1  - Bannister, R.
A1  - Buisman, K.
A1  - Capriglione, D.
A1  - Di Capua, G.
A1  - García-Patrón, M.
A1  - Gatzweiler, Thomas
A1  - Gellersen, F.
A1  - Harzheim, Thomas
A1  - Heuermann, Holger
A1  - Hoffmann, J.
A1  - Izbrodin, A.
A1  - Kuhlmann, K.
A1  - Lahbacha, K.
A1  - Maffucci, A.
A1  - Miele, G.
A1  - Mubarak, F.
A1  - Salter, M.
A1  - Pham, T.D.
A1  - Sayegh, A.
A1  - Singh, D.
A1  - Stein, F.
A1  - Zeier, M.
T1  - RF measurements for future communication applications: an overview
T2  - 2022 IEEE International Symposium on Measurements & Networking (M&N)
N2  - In this paper research activities developed within the FutureCom project are presented. The project, funded by the European Metrology Programme for Innovation and Research (EMPIR), aims at evaluating and characterizing: (i) active devices, (ii) signal- and power integrity of field programmable gate array (FPGA) circuits, (iii) operational performance of electronic circuits in real-world and harsh environments (e.g. below and above ambient temperatures and at different levels of humidity), (iv) passive inter-modulation (PIM) in communication systems considering different values of temperature and humidity corresponding to the typical operating conditions that we can experience in real-world scenarios. An overview of the FutureCom project is provided here, then the research activities are described.
KW  - FPGA
KW  - signal integrity
KW  - power integrity
KW  - passive inter-modulation
KW  - metrological characterization
Y1  - 2022
SN  - 978-1-6654-8362-9
SN  - 978-1-6654-8363-6
U6  - http://dx.doi.org/10.1109/MN55117.2022.9887740
SN  - 2639-5061
SN  - 2639-507X
N1  - 2022 IEEE International Symposium on Measurements & Networking (M&N), 18-20 July 2022, Padua, Italy.
SP  - 1
EP  - 6
PB  - IEEE
ER  - 
TY  - JOUR
A1  - Allefeld, Carsten
A1  - Bialonski, Stephan
T1  - Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains
JF  - Physical Review E
Y1  - 2007
U6  - http://dx.doi.org/10.1103/PhysRevE.76.066207
SN  - 2470-0053
VL  - 76
IS  - 6
SP  - 066207
ER  - 
TY  - JOUR
A1  - Almajhdi, Fahad N.
A1  - Senger, Tilo
A1  - Amer, Haitham M.
A1  - Gissmann, Lutz
A1  - Öhlschläger, Peter
T1  - Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling)
JF  - PLOS one
N2  - Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism.
Y1  - 2014
U6  - http://dx.doi.org/10.1371/journal.pone.0113461
SN  - 1932-6203
VL  - 11
IS  - 9
PB  - PLOS
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Alnemer, Momin Sami Mohammad
A1  - Kotliar, Konstantin
A1  - Neuhaus, Valentin
A1  - Pape, Hans-Christoph
A1  - Ciritsis, Bernhard D.
T1  - Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model
JF  - Cost Effectiveness and Resource Allocation
N2  - Background
Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices.

Methods
This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare & Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results.

Results
With a 10% fracture risk reduction, model A costs between $8,850 and $46,940 per quality-adjusted life-year ($/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side’s prophylaxis, the patient’s age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between $11,000/QALY and $74,000/QALY, which is below the defined willingness to pay threshold.

Conclusion
Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.
KW  - Hip fractures
KW  - Prevention
KW  - Geriatric
KW  - Cost-effectiveness
KW  - Prophylaxis
Y1  - 2023
U6  - http://dx.doi.org/10.1186/s12962-023-00482-4
SN  - 1478-7547
N1  - Corresponding author: Momin S. Alnemer
IS  - 21, Article number: 77
PB  - Springer Nature
ER  - 
TY  - CHAP
A1  - Altay, Okyay
A1  - Butenweg, Christoph
A1  - Klinkel, Sven
T1  - Vibration control of slender structures by semi-active tuned liquid column dampers
T2  - Conference of the ASCE Engineering Mechanics Institute , Evanston, IL , USA , EMI 2013 , 2013-08-04 - 2013-08-07
Y1  - 2013
N1  - http://www.emi2013.northwestern.edu/openconf/modules/request.php?module=oc_program&action=view.php&a=&id=213&type=1
Seite kann nicht gefunden werden.
ER  - 
TY  - CHAP
A1  - Altay, Okyay
A1  - Butenweg, Christoph
A1  - Klinkel, Sven
T1  - Vibration mitigation of wind turbine towers by a new semiactive Tuned Liquid Column Damper
T2  - 6. Word Congress on Structural Control and Monitoring, 15 - 17 July, 2014 Barcelona,Spain
Y1  - 2014
ER  - 
TY  - CHAP
A1  - Altay, Okyay
A1  - Butenweg, Christoph
A1  - Klinkel, Sven
A1  - Taddei, Francesca
T1  - Vibration mitigation of wind turbine towers by tuned liquid column dampers
T2  - Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.)
Y1  - 2014
SN  - 978-972-752-165-4
SP  - 1531
EP  - 1538
CY  - Porto
ER  - 
TY  - CHAP
A1  - Altay, Okyay
A1  - Taddei, Francesca
A1  - Butenweg, Christoph
A1  - Klinkel, Sven
T1  - Vibration mitigation of wind turbine towers with tuned mass dampers
T2  - Wind turbine control and monitoring. (Advances in industrial control)
N2  - Because of its minor environmental impact, electricity generation using wind power is getting remarkable. The further growth of the wind industry depends on technological solutions to the challenges in production and construction of the turbines. Wind turbine tower vibrations, which limit power generation efficiency and cause fatigue problems with high maintenance costs, count as one of the main structural difficulties in the wind energy sector. To mitigate tower vibrations auxiliary measures are necessary. The effectiveness of tuned mass damper is verified by means of a numeric study on a 5 MW onshore reference wind turbine. Hereby, also seismic-induced vibrations and soil–structure interaction are considered. Acquired results show that tuned mass damper can effectively reduce resonant tower vibrations and improve the fatigue life of wind turbines. This chapter is also concerned with tuned liquid column damper and a semiactive application of it. Due to its geometric versatility and low prime costs, tuned liquid column dampers are a good alternative to other damping measures, in particular for slender structures like wind turbines.
Y1  - 2014
SN  - 978-3-319-08412-1 (Print) ; 978-3-319-08413-8 (E-Book)
U6  - http://dx.doi.org/10.1007/978-3-319-08413-8_12
SP  - 337
EP  - 373
PB  - Springer
CY  - Cham ; Heidelberg ; New York ; Dordrecht ; London
ER  - 
TY  - BOOK
A1  - Altherr, Lena
T1  - Algorithmic System Design under Consideration of Dynamic Processes
N2  - Nach Stand von Wissenschaft und Technik werden Komponenten hinsichtlich ihrer Eigenschaften, wie Lebensdauer oder Energieeffizienz, optimiert. Allerdings können selbst hervorragende Komponenten zu ineffizienten oder instabilen Systemen führen, wenn ihr Zusammenspiel nur unzureichend berücksichtigt wird. Eine Systembetrachtung schafft ein größeres Optimierungspotential - dem erhöhten Potential steht jedoch auch ein erhöhter Komplexitätsgrad gegenüber. Die vorliegende Arbeit ist im Rahmen des Sonderforschungsbereichs 805 entstanden, dessen Ziel die Beherrschung von Unsicherheit in Systemen des Maschinenbaus ist. Die Arbeit zeigt anhand eines realen Systems aus dem Bereich der Hydraulik, wie Unsicherheit in der Entwicklungsphase beherrscht werden kann. Hierbei ist neu, dass die durch den späteren Betrieb zu erwartende Systemdegradation eines jeden möglichen Systemvorschlags antizipiert werden kann. Dadurch können Betriebs- und Wartungskosten vorausgesagt und minimiert werden und durch eine optimale Betriebs- und Wartungsstrategie die Verfügbarkeit des Systems garantiert werden. Wesentliche Fragen bei der optimalen Auslegung des betrachteten hydrostatischen Getriebes sind dessen physikalische Modellierung, die Darstellung des Optimierungsproblems als gemischt-ganzzahliges lineares Programm, und dessen algorithmische Behandlung zur Lösungsfindung. Hierzu werden Heuristiken zum schnelleren Auffinden sinnvoller Systemtopologien vorgestellt und mittels mathematischer Dekomposition eine Bewertung des dynamischen Verschleiß- und Wartungsverlaufs möglicher Systemvorschläge vorgenommen. Die Arbeit stellt die Optimierung technischer Systeme an der Schnittstelle von Mathematik, Informatik und Ingenieurwesen sowohl gründlich als auch anschaulich und nachvollziehbar dar.
KW  - Mixed Integer Programming
KW  - Technical Operations Research
KW  - Optimization
KW  - System Design
Y1  - 2016
SN  - 978-3-8440-4848-3
PB  - Shaker
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Brötz, Nicolas
A1  - Dietrich, Ingo
A1  - Gally, Tristan
A1  - Geßner, Felix
A1  - Kloberdanz, Hermann
A1  - Leise, Philipp
A1  - Pelz, Peter Franz
A1  - Schlemmer, Pia
A1  - Schmitt, Andreas
T1  - Resilience in mechanical engineering - a concept for controlling uncertainty during design, production and usage phase of load-carrying structures
JF  - Applied Mechanics and Materials
N2  - Resilience as a concept has found its way into different disciplines to describe the ability of an individual or system to withstand and adapt to changes in its environment. In this paper, we provide an overview of the concept in different communities and extend it to the area of mechanical engineering. Furthermore, we present metrics to measure resilience in technical systems and illustrate them by applying them to load-carrying structures. By giving application examples from the Collaborative Research Centre (CRC) 805, we show how the concept of resilience can be used to control uncertainty during different stages of product life.
Y1  - 2018
SN  - 1662-7482
U6  - http://dx.doi.org/10.4028/www.scientific.net/AMM.885.187
VL  - 885
SP  - 187
EP  - 198
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - CHAP
A1  - Altherr, Lena
A1  - Conzen, Max
A1  - Elsen, Ingo
A1  - Frauenrath, Tobias
A1  - Lyrmann, Andreas
ED  - Reiff-Stephan, Jörg
ED  - Jäkel, Jens
ED  - Schwarz, André
T1  - Sensor retrofitting of existing buildings in an interdisciplinary teaching project at university level
T2  - Tagungsband AALE 2023 : mit Automatisierung gegen den Klimawandel
N2  - Existing residential buildings have an average lifetime of 100 years. Many of these buildings will exist for at least another 50 years. To increase the efficiency of these buildings while keeping costs at reasonable rates, they can be retrofitted with sensors that deliver information to central control units for heating, ventilation and electricity. This retrofitting process should happen with minimal intervention into existing infrastructure and requires new approaches for sensor design and data transmission. At FH Aachen University of Applied Sciences, students of different disciplines work together to learn how to design, build, deploy and operate such sensors. The presented teaching project already created a low power design for a combined CO2, temperature and humidity measurement device that can be easily integrated into most home automation systems
KW  - Building Automation
KW  - Smart Building
KW  - CO2
KW  - Carbon Dioxide
KW  - Education
Y1  - 2023
SN  - 978-3-910103-01-6
U6  - http://dx.doi.org/10.33968/2023.04
N1  - 19. AALE-Konferenz. Luxemburg, 08.03.-10.03.2023.
BTS Connected Buildings & Cities Luxemburg
(Tagungsband unter https://doi.org/10.33968/2023.01)
SP  - 31
EP  - 40
PB  - le-tex publishing services GmbH
CY  - Leipzig
ER  - 
TY  - CHAP
A1  - Altherr, Lena
A1  - Dörig, Bastian
A1  - Ederer, Thorsten
A1  - Pelz, Peter Franz
A1  - Pfetsch, Marc
A1  - Wolf, Jan
T1  - A mixed-integer nonlinear program for the design of gearboxes
T2  - Operations Research Proceedings 2016
N2  - Gearboxes are mechanical transmission systems that provide speed and torque conversions from a rotating power source. Being a central element of the drive train, they are relevant for the efficiency and durability of motor vehicles. In this work, we present a new approach for gearbox design: Modeling the design problem as a mixed-integer nonlinear program (MINLP) allows us to create gearbox designs from scratch for arbitrary requirements and—given enough time—to compute provably globally optimal designs for a given objective. We show how different degrees of freedom influence the runtime and present an exemplary solution.
Y1  - 2017
SN  - 978-3-319-55701-4
U6  - http://dx.doi.org/10.1007/978-3-319-55702-1_31
SP  - 227
EP  - 233
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Altherr, Lena
A1  - Ederer, Thorsten
A1  - Farnetane, Lucas S.
A1  - Pöttgen, Philipp
A1  - Vergé, Angela
A1  - Pelz, Peter F.
T1  - Multicriterial design of a hydrostatic transmission system via mixed-integer programming
T2  - Operations Research Proceedings 2015
N2  - In times of planned obsolescence the demand for sustainability keeps growing. Ideally, a technical system is highly reliable, without failures and down times due to fast wear of single components. At the same time, maintenance should preferably be limited to pre-defined time intervals. Dispersion of load between multiple components can increase a system’s reliability and thus its availability inbetween maintenance points. However, this also results in higher investment costs and additional efforts due to higher complexity. Given a specific load profile and resulting wear of components, it is often unclear which system structure is the optimal one. Technical Operations Research (TOR) finds an optimal structure balancing availability and effort. We present our approach by designing a hydrostatic transmission system.
Y1  - 2017
SN  - 978-3-319-42901-4
SN  - 978-3-319-42902-1
U6  - http://dx.doi.org/10.1007/978-3-319-42902-1_41
N1  - International Conference of the German, Austrian and Swiss Operations Research Societies (GOR, ÖGOR, SVOR/ASRO), University of Vienna, Austria, September 1-4, 2015
SP  - 301
EP  - 307
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Altherr, Lena
A1  - Ederer, Thorsten
A1  - Lorenz, Ulf
A1  - Pelz, Peter F.
A1  - Pöttgen, Philipp
ED  - Lübbecke, Marco E.
ED  - Koster, Arie
ED  - Letmathe, Peter
ED  - Madlener, Reihard
ED  - Preis, Britta
ED  - Walther, Grit
T1  - Designing a feedback control system via mixed-integer programming
T2  - Operations Research Proceedings 2014: Selected Papers of the Annual International Conference of the German Operations Research
N2  - Pure analytical or experimental methods can only find a control strategy for technical systems with a fixed setup. In former contributions we presented an approach that simultaneously finds the optimal topology and the optimal open-loop control of a system via Mixed Integer Linear Programming (MILP). In order to extend this approach by a closed-loop control we present a Mixed Integer Program for a time discretized tank level control. This model is the basis for an extension by combinatorial decisions and thus for the variation of the network topology. Furthermore, one is able to appraise feasible solutions using the global optimality gap.
KW  - Optimal Topology
KW  - Controller Parameter
KW  - Level Control System
KW  - Technical Operation Research
KW  - Optimal Closed Loop
Y1  - 2016
SN  - 978-3-319-28695-2
U6  - http://dx.doi.org/10.1007/978-3-319-28697-6_18
SP  - 121
EP  - 127
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Ederer, Thorsten
A1  - Lorenz, Ulf
A1  - Pelz, Peter F.
A1  - Pöttgen, Philipp
ED  - Lübbecke, Marco
ED  - Koster, Arie
ED  - Letmathe, Peter
ED  - Madlener, Reihard
ED  - Peis, Britta
ED  - Walther, Grit
T1  - Experimental validation of an enhanced system synthesis approach
JF  - Operations Research Proceedings 2014
N2  - Planning the layout and operation of a technical system is a common task
for an engineer. Typically, the workflow is divided into consecutive stages: First,
the engineer designs the layout of the system, with the help of his experience or of
heuristic methods. Secondly, he finds a control strategy which is often optimized
by simulation. This usually results in a good operating of an unquestioned sys-
tem topology. In contrast, we apply Operations Research (OR) methods to find a
cost-optimal solution for both stages simultaneously via mixed integer program-
ming (MILP). Technical Operations Research (TOR) allows one to find a provable
global optimal solution within the model formulation. However, the modeling error
due to the abstraction of physical reality remains unknown. We address this ubiq-
uitous problem of OR methods by comparing our computational results with mea-
surements in a test rig. For a practical test case we compute a topology and control
strategy via MILP and verify that the objectives are met up to a deviation of 8.7%.
Y1  - 2014
SN  - 978-3-319-28695-2
U6  - http://dx.doi.org/10.1007/978-3-319-28697-6_1
PB  - Springer
CY  - Basel
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Ederer, Thorsten
A1  - Pöttgen, Philipp
A1  - Lorenz, Ulf
A1  - Pelz, Peter F.
ED  - Pelz, Peter F.
ED  - Groche, Peter
T1  - Multicriterial optimization of technical systems considering multiple load and availability scenarios
JF  - Applied Mechanics and Materials
N2  - Cheap does not imply cost-effective -- this is rule number one of zeitgeisty system design. The initial investment accounts only for a small portion of the lifecycle costs of a technical system. In fluid systems, about ninety percent of the total costs are caused by other factors like power consumption and maintenance. With modern optimization methods, it is already possible to plan an optimal technical system considering multiple objectives. In this paper, we focus on an often neglected contribution to the lifecycle costs: downtime costs due to spontaneous failures. Consequently, availability becomes an issue.
KW  - sustainability
KW  - availability
KW  - energy efficiency
KW  - mixed-integer linear programming
KW  - system synthesis
Y1  - 2015
SN  - 1660-9336
U6  - http://dx.doi.org/10.4028/www.scientific.net/AMM.807.247
VL  - 807
SP  - 247
EP  - 256
ER  - 
TY  - CHAP
A1  - Altherr, Lena
A1  - Ederer, Thorsten
A1  - Schänzle, Christian
A1  - Lorenz, Ulf
A1  - Pelz, Peter F.
T1  - Algorithmic system design using scaling and affinity laws
T2  - Operations Research Proceedings 2015
N2  - Energy-efficient components do not automatically lead to energy-efficient systems. Technical Operations Research (TOR) shifts the focus from the single component to the system as a whole and finds its optimal topology and operating strategy simultaneously. In previous works, we provided a preselected construction kit of suitable components for the algorithm. This approach may give rise to a combinatorial explosion if the preselection cannot be cut down to a reasonable number by human intuition. To reduce the number of discrete decisions, we integrate laws derived from similarity theory into the optimization model. Since the physical characteristics of a production series are similar, it can be described by affinity and scaling laws. Making use of these laws, our construction kit can be modeled more efficiently: Instead of a preselection of components, it now encompasses whole model ranges. This allows us to significantly increase the number of possible set-ups in our model. In this paper, we present how to embed this new formulation into a mixed-integer program and assess the run time via benchmarks. We present our approach on the example of a ventilation system design problem.
KW  - Optimal Topology
KW  - Piecewise Linearization
KW  - Ventilation System
KW  - Similarity Theory
Y1  - 2017
SN  - 978-3-319-42901-4
SN  - 978-3-319-42902-1
U6  - http://dx.doi.org/10.1007/978-3-319-42902-1
N1  - International Conference of the German, Austrian and Swiss Operations Research Societies (GOR, ÖGOR, SVOR/ASRO), University of Vienna, Austria, September 1-4, 2015
SP  - 605
EP  - 611
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Joggerst, Laura
A1  - Leise, Philipp
A1  - Pfetsch, Marc E.
A1  - Schmitt, Andreas
A1  - Wendt, Janine
T1  - On obligations in the development process of resilient systems with algorithmic design methods
JF  - Applied Mechanics and Materials
N2  - Advanced computational methods are needed both for the design of large systems and to compute high accuracy solutions. Such methods are efficient in computation, but the validation of results is very complex, and highly skilled auditors are needed to verify them. We investigate legal questions concerning obligations in the development phase, especially for technical systems developed using advanced methods. In particular, we consider methods of resilient and robust optimization. With these techniques, high performance solutions can be found, despite a high variety of input parameters. However, given the novelty of these methods, it is uncertain whether legal obligations are being met. The aim of this paper is to discuss if and how the choice of a specific computational method affects the developer’s product liability. The review of legal obligations in this paper is based on German law and focuses on the requirements that must be met during the design and development process.
KW  - legal obligations
KW  - product liability
KW  - design of technical systems
KW  - optimization
KW  - resilience
Y1  - 2018
SN  - 1662-7482
U6  - http://dx.doi.org/10.4028/www.scientific.net/AMM.885.240
VL  - 885
IS  - 885
SP  - 240
EP  - 252
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - CHAP
A1  - Altherr, Lena
A1  - Leise, Philipp
T1  - Resilience as a concept for mastering uncertainty
T2  - Mastering Uncertainty in Mechanical Engineering
Y1  - 2021
SN  - 978-3-030-78353-2
U6  - http://dx.doi.org/10.1007/978-3-030-78354-9
N1  - Unterkapitel 6.3.1 des Kapitels "Strategies for Mastering Uncertainty"
SP  - 412
EP  - 417
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Altherr, Lena
A1  - Leise, Philipp
A1  - Pfetsch, Marc E.
A1  - Schmitt, Andreas
T1  - Algorithmic design and resilience assessment of energy efficient high-rise water supply systems
JF  - Applied Mechanics and Materials
N2  - High-rise water supply systems provide water flow and suitable pressure in all levels of tall buildings. To design such state-of-the-art systems, the consideration of energy efficiency and the anticipation of component failures are mandatory. In this paper, we use Mixed-Integer Nonlinear Programming to compute an optimal placement of pipes and pumps, as well as an optimal control strategy.Moreover, we consider the resilience of the system to pump failures. A resilient system is able to fulfill a predefined minimum functionality even though components fail or are restricted in their normal usage. We present models to measure and optimize the resilience. To demonstrate our approach, we design and analyze an optimal resilient decentralized water supply system inspired by a real-life hotel building.
KW  - MINLP
KW  - Buffering Capacity
KW  - Uncertainty
KW  - Water Supply Networks
KW  - Booster Stations
Y1  - 2018
U6  - http://dx.doi.org/10.4028/www.scientific.net/AMM.885.211
SN  - 1662-7482
VL  - 885
SP  - 211
EP  - 223
PB  - Trans Tech Publications
CY  - Bäch
ER  - 
TY  - CHAP
A1  - Altherr, Lena
A1  - Leise, Philipp
A1  - Pfetsch, Marc E.
A1  - Schmitt, Andreas
T1  - Optimal design of resilient technical systems on the example of water supply systems
T2  - Mastering Uncertainty in Mechanical Engineering
Y1  - 2021
SN  - 978-3-030-78356-3
N1  - Unterkapitel des Kapitels "Strategies for Mastering Uncertainty"
SP  - 429
EP  - 433
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Amin, Rashid
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Lazarovici, Philip
A1  - Lelkes, Peter I.
T1  - Permeability of an In Vitro Model of Blood Brain Barrier (BBB)
JF  - 13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]
Y1  - 2009
SN  - 978-3-540-92841-6
N1  - IFMBE Proceedings ; 23, Track 1 ; ICBME 2008 3–6 December 2008 Singapore
SP  - 81
EP  - 84
ER  - 
TY  - CHAP
A1  - Amir, Malik
A1  - Bauckhage, Christian
A1  - Chircu, Alina
A1  - Czarnecki, Christian
A1  - Knopf, Christian
A1  - Piatkowski, Nico
A1  - Sultanow, Eldar
T1  - What can we expect from quantum (digital) twins?
N2  - Digital twins enable the modeling and simulation of real-world entities
(objects, processes or systems), resulting in improvements in the associated value
chains. The emerging field of quantum computing holds tremendous promise for
evolving this virtualization towards Quantum (Digital) Twins (QDT) and
ultimately Quantum Twins (QT). The quantum (digital) twin concept is not a
contradiction in terms - but instead describes a hybrid approach that can be
implemented using the technologies available today by combining classical
computing and digital twin concepts with quantum processing. This paper
presents the status quo of research and practice on quantum (digital) twins. It also
discuses their potential to create competitive advantage through real-time
simulation of highly complex, interconnected entities that helps companies better
address changes in their environment and differentiate their products and
services.
KW  - Artificial Intelligence
KW  - Digital Twin Evolution
KW  - Machine Learning
KW  - Quantum Computing
KW  - Quantum Machine Learning
Y1  - 2022
N1  - 17. Internationale Tagung Wirtschaftsinformatik, 21. – 23. Februar 2022, Nürnberg (online)
SP  - 1
EP  - 14
PB  - AIS Electronic Library (AISeL)
ER  - 
TY  - JOUR
A1  - Anding, Ralf
A1  - Tabaza, Ruth
A1  - Staat, Manfred
A1  - Trenz, Eva
A1  - Lohmann, Philipp
A1  - Klinge, Uwe
A1  - Kirschner-Hermanns, Ruth
T1  - Introducing a method of in vitro testing of different anchoring systems used for female incontinence and prolapse surgery
JF  - BioMed research international
Y1  - 2013
SN  - 1110-7251 (E-Journal); 2314-6141 (E-Journal); 1110-7243 (Print); 2314-6133 (Print)
VL  - Vol. 2013
SP  - Article ID 401417
ER  - 
TY  - JOUR
A1  - Angermann, Susanne
A1  - Günthner, Roman
A1  - Hanssen, Henner
A1  - Lorenz, Georg
A1  - Braunisch, Matthias C.
A1  - Steubl, Dominik
A1  - Matschkal, Julia
A1  - Kemmner, Stephan
A1  - Hausinger, Renate
A1  - Block, Zenonas
A1  - Haller, Bernhard
A1  - Heemann, Uwe
A1  - Kotliar, Konstantin
A1  - Grimmer, Timo
A1  - Schmaderer, Christoph
T1  - Cognitive impairment and microvascular function in end-stage renal disease
JF  - International Journal of Methods in Psychiatric Research (MPR)
N2  - Objective
Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels.

Methods
152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions.

Results
In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained.

Conclusion
This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.
KW  - cerebral small vessel disease
KW  - cognitive impairment
KW  - dialysis
KW  - retinal vessels
Y1  - 2022
U6  - http://dx.doi.org/10.1002/mpr.1909
SN  - 1049-8931 (Print)
SN  - 1557-0657 (Online)
VL  - 31
IS  - 2
SP  - 1
EP  - 10
PB  - Wiley
ER  - 
TY  - CHAP
A1  - Anic, Filip
A1  - Penava, Davorin
A1  - Guljas, Ivica
A1  - Sarhosis, Vasilis
A1  - Abrahamczyk, Lars
A1  - Butenweg, Christoph
T1  - The Effect of Openings on Out-of-Plane Capacity of Masonry Infilled Reinforced Concrete Frames
T2  - 16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018
Y1  - 2018
N1  - Paper No 10168
SP  - 1
EP  - 11
ER  - 
TY  - CHAP
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
ED  - Brodowsky, Horst
T1  - Thermodynamic behaviour of oxygen in molten metallic alloys
T2  - Thermochemistry of alloys : recent developments of experimental methods ; [proceedings of the NATO Advanced Study Institute on Thermochemistry of Alloys, Recent Developments of Experimental Methods, Kiel, F.R.G., August 17 - 27, 1987]. - (NATO ASI series : Series C ; 286)
Y1  - 1989
SN  - 0-7923-0434-9
SP  - 419
EP  - 428
PB  - Springer
CY  - Dordrecht [u.a.]
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
T1  - Thermodynamics and solubility of oxygen in liquid copper-lead alloys at 1200°C from E.M.F. measurements
JF  - Berichte der Bunsengesellschaft für physikalische Chemie
Y1  - 1984
SN  - 0940-483X
SN  - 0005-9021
VL  - 88
IS  - 8
SP  - 707
EP  - 710
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
T1  - Thermodynamics and solubility of oxygen in liquid bismuth-lead and bismuth-antimony alloys
JF  - Berichte der Bunsengesellschaft für physikalische Chemie
Y1  - 1987
SN  - 0940-483X
SN  - 0005-9021
VL  - 91
IS  - 7
SP  - 790
EP  - 794
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
T1  - Investigations of the thermodynamics of oxygen and the determination of the miscibility gap in the system copper-oxygen-lead at 12000C
JF  - Zeitschrift für Metallkunde
Y1  - 1984
SN  - 0044-3093
VL  - 75
IS  - 8
SP  - 586
EP  - 589
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
T1  - Investigation of the thermodynamics of oxygen and the determination of phase boundaries in the system copper-oxygen-bismuth at 12000C
JF  - Zeitschrift für Metallkunde
Y1  - 1983
SN  - 0044-3093
VL  - 74
IS  - 8
SP  - 530
EP  - 534
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
T1  - Thermodynamics of oxygen in the copper-antimony system at 1473K
JF  - Erzmetall : Rohstoffgewinnung, Verarbeitung, Recycling, Umwelttechnik
Y1  - 1988
SN  - 0044-2658
VL  - 41
IS  - 10
SP  - 498
EP  - 501
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
A1  - Kapoor, Madan Lal
T1  - Experiments and theoretical considerations on the solution of oxygen in binary metal alloys
JF  - Berichte der Bunsengesellschaft für physikalische Chemie
Y1  - 1983
SN  - 0005-9021
SN  - 0940-483X
VL  - 87
IS  - 12
SP  - 1201
EP  - 1204
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
A1  - Kapoor, Madan Lal
T1  - Prediction of thermodynamic properties of oxygen in binary metallic solvents
JF  - Zeitschrift für Metallkunde
Y1  - 1983
SN  - 0044-3093
VL  - 74
IS  - 6
SP  - 372
EP  - 375
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Kapoor, Madan Lal
A1  - Frohberg, Martin G.
T1  - Thermodynamic behaviour of oxygen in molten substitutional alloy solvents
JF  - Zeitschrift für Metallkunde
Y1  - 1983
SN  - 0044-3093
VL  - 74
IS  - 1
SP  - 53
EP  - 58
ER  - 
TY  - CHAP
A1  - Anthrakidis, Anette
A1  - Herrmann, Ulf
A1  - Schorn, Christian
A1  - Schwarzer, Klemens
A1  - Wedding, Philipp
A1  - Weis, Fabian
T1  - Development and Testing of a Novel Method for the Determination of the Efficiency of Concentrating Solar Thermal Collectors
T2  - Conference Proceedings Solar World Congress 2015, Daegu, Korea, 08 – 12 November 2015
Y1  - 2015
ER  - 
TY  - CHAP
A1  - Anthrakidis, Anette
A1  - Rusack, Markus
A1  - Schwarzer, Klemens
T1  - Low effort measurement method of PTC-efficiency
T2  - SolarPACES 2010 : the CSP conference: electricity, fuels and clean water from concentrated solar energy ; 21 to 24 September 2010, Perpignan, France
Y1  - 2010
SP  - 48
EP  - 49
PB  - Soc. OSC
CY  - Saint Maur
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Karamanidis, Kiros
A1  - Albracht, Kirsten
T1  - Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude
JF  - Journal of Experimental Biology
Y1  - 2007
U6  - http://dx.doi.org/10.1242/jeb.003814
SN  - 0022-0949
VL  - 210
IS  - 15
SP  - 2743
EP  - 2753
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Karamanidis, Kiros
A1  - Mademli, Lida
A1  - Albracht, Kirsten
T1  - Plasticity of the human tendon to short and long-term mechanical loading
JF  - Exercise and Sport Sciences Reviews
Y1  - 2009
U6  - http://dx.doi.org/10.1097/JES.0b013e31819c2e1d
SN  - 1538-3008
VL  - 37
IS  - 2
SP  - 66
EP  - 72
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Peper, Andreas
A1  - Bierbaum, Stefanie
A1  - Albracht, Kirsten
T1  - Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain
JF  - Journal of Biomechanics
N2  - The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47%), and the other leg at high tendon strain magnitude (4.72±1.08%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon–aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon–aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.
Y1  - 2010
U6  - http://dx.doi.org/10.1016/j.jbiomech.2010.08.014
SN  - 0021-9290
VL  - 43
IS  - 16
SP  - 3073
EP  - 3079
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arida, Hassan A.
A1  - Al-haddad, Ameera
A1  - Schöning, Michael Josef
T1  - New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode
JF  - International Journal of Electrochemical Science. 6 (2011), H. 9
Y1  - 2011
SN  - 1452-3981
SP  - 3858
EP  - 3867
ER  - 
TY  - CHAP
A1  - Arida, Hassan A.
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
T1  - Novel organic membrane-based thin-film microsensors for the determination of heavy metal cations
N2  - A first step towards the fabrication and electrochemical evaluation of thin-film microsensors based on organic PVC membranes for the determination of Hg(II), Cd(II), Pb(II) and Cu(II) ions in solutions has been realised. The membrane-coating mixture used in the preparation of this new type of microsensors is incorporating PVC as supporting matrix, o-nitrophenyloctylether (o-NPOE) as solvent mediator and a recently synthesized Hg[dimethylglyoxime(phene)]2+ and Bis-(4-hydroxyacetophenone)-ethylenediamine as electroactive materials for Hg(II) and Cd(II), respectively. A set of three commercialised ionophores for Cd(II), Pb(II) and Cu(II) has been also used for comparison. Thin-film microsensors based on these membranes showed a Nernstian response of slope (26-30 mV/dec.) for the respective tested cations. The potentiometric response characteristics (linear range, pH range, detection limit and response time) are comparable with those obtained by conventional membranes as well as coated wire electrodes prepared from the same membrane. The realisation of the new organic membrane-based thin-film microsensors overcomes the problem of an insufficient selectivity of solid-state-based thinfilm sensors.
KW  - Biosensor
KW  - Heavy metal detection
KW  - thin-film microsensors
KW  - organic PVC membranes
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1545
ER  - 
TY  - JOUR
A1  - Arida, Hassan
A1  - Mohsen, Q.
A1  - Schöning, Michael Josef
T1  - Microfabrication, characterization and analytical application of a new thin-film silver microsensor
JF  - Electrochimica Acta. 54 (2009), H. 13
Y1  - 2009
SN  - 0013-4686
SP  - 3543
EP  - 3547
ER  - 
TY  - JOUR
A1  - Arida, Hassan
A1  - Turek, Monika
A1  - Rolka, David
A1  - Schöning, Michael Josef
T1  - A Novel Thin-Film Copper Array Based on an Organic/Inorganic Sensor Hybrid: Microfabrication, Potentiometric Characterization, and Flow-Injection Analysis Application
JF  - Electroanalysis. 21 (2009), H. 10
Y1  - 2009
SN  - 1040-0397
SP  - 1145
EP  - 1151
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Aringhoff, R.
A1  - Geyer, Michael
A1  - Herrmann, Ulf
A1  - Kistner, Rainer
A1  - Nava, P.
A1  - Osuna, R.
ED  - Steinfeld, Aldo
T1  - AndaSol : 50MW Solar Plants with 9 Hour Storage for Southern Spain
T2  - Proceedings of the 11th SolarPACES International Symposium on Concentrated Solar Power and Chemical Energy Technologies : September 4 - 6, 2002, Zurich, Switzerland / Paul Scherrer Institut, PSI; ETH, Eidgenössische Technische Hochschule Zürich
Y1  - 2002
SN  - 3-9521409-3-7
SP  - 37
EP  - 42
PB  - Paul Scherrer Inst.
CY  - Villingen
ER  - 
TY  - CHAP
A1  - Arinkin, Vladimir
A1  - Digel, Ilya
T1  - Water bridge phenomenon : [abstract]
N2  - One of interesting but not well known water properties is related to appearance of highly ordered structures in response to strong electrical field. In 1893 Sir William Armstrong placed a cotton thread between two wine glasses filled with chemically pure water. When high DC voltage was applied between the glasses, a connection consisting of water formed, producing a "water bridge"
KW  - Hydrodynamik
KW  - Elektrodynamik
KW  - Wasserbrücke
KW  - water bridge phenomenon
Y1  - 2009
ER  - 
TY  - JOUR
A1  - Arinkin, Vladimir
A1  - Digel, Ilya
A1  - Porst, Dariusz
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application
JF  - BMC bioinformatics
N2  - Background
True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN).

Results
Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm.

Conclusions
Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1% and reached 100% in one of the best ANN.
Y1  - 2014
U6  - http://dx.doi.org/10.1186/1471-2105-15-55
SN  - 1471-2105
VL  - 15
IS  - 55
SP  - 1
EP  - 8
ER  - 
TY  - CHAP
A1  - Arndt, Tobias
A1  - Conzen, Max
A1  - Elsen, Ingo
A1  - Ferrein, Alexander
A1  - Galla, Oskar
A1  - Köse, Hakan
A1  - Schiffer, Stefan
A1  - Tschesche, Matteo
T1  - Anomaly detection in the metal-textile industry for the reduction of the cognitive load of quality control workers
T2  - PETRA '23: Proceedings of the 16th International Conference on PErvasive Technologies Related to Assistive Environments
N2  - This paper presents an approach for reducing the cognitive load for humans working in quality control (QC) for production processes that adhere to the 6σ -methodology. While 100% QC requires every part to be inspected, this task can be reduced when a human-in-the-loop QC process gets supported by an anomaly detection system that only presents those parts for manual inspection that have a significant likelihood of being defective. This approach shows good results when applied to image-based QC for metal textile products.
KW  - Datasets
KW  - Neural networks
KW  - Anomaly detection
KW  - Quality control
KW  - Process optimization
Y1  - 2023
SN  - 9798400700699
U6  - http://dx.doi.org/10.1145/3594806.3596558
N1  - PETRA '23: Proceedings of the 16th International Conference on Pervasive Technologies Related to Assistive Environments, Corfu Greece, July 5 - 7, 2023.
SP  - 535
EP  - 542
PB  - ACM
ER  - 
TY  - JOUR
A1  - Arpshofen, Ingo
A1  - Pool, M. J.
A1  - Sommer, Ferdinand
A1  - Gerling, Ulrich
A1  - Predel, Bruno
A1  - Schultheiss, Emil
T1  - Determination of the integral mixing enthalpies in the Cu-Pd-Si liquid ternary alloy system at 1600 K
JF  - Zeitschrift für Metallkunde : international journal of materials research and advanced techniques. Bd. 74, H. 1
Y1  - 1983
SN  - 0044-3093 ; 0179-4841
SP  - 25
EP  - 32
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Effect of O2 plasma on properties of electrolyte-insulator-semiconductor structures
JF  - physica status solidi a : applications and materials sciences
N2  - Prior to immobilization of biomolecules or cells onto biosensor surfaces, the surface must be physically or chemically activated for further functionalization. Organosilanes are a versatile option as they facilitate the immobilization through their terminal groups and also display self-assembly. Incorporating hydroxyl groups is one of the important methods for primary immobilization. This can be done, for example, with oxygen plasma treatment. However, this treatment can affect the performance of the biosensors and this effect is not quite well understood for surface functionalization. In this work, the effect of O2 plasma treatment on EIS sensors was investigated by means of electrochemical characterizations: capacitance–voltage (C–V) and constant capacitance (ConCap) measurements. After O2 plasma treatment, the potential of the EIS sensor dramatically shifts to a more negative value. This was successfully reset by using an annealing process.
KW  - surface functionalization
KW  - O2 plasma
KW  - hydroxylation
KW  - electrolyte-insulator semiconductor sensor (EIS)
KW  - annealing
Y1  - 2017
U6  - http://dx.doi.org/10.1002/pssa.201700025
SN  - 1862-6319
VL  - 214
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Toward an immobilization method for spore-based biosensors in oxidative environment
JF  - Electrochimica Acta
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.electacta.2019.01.148
VL  - 302
SP  - 394
EP  - 401
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Combined calorimetric gas- and spore-based biosensor array for online monitoring and sterility assurance of gaseous hydrogen peroxide in aseptic filling machines
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.111628
SN  - 0956-5663
VL  - 143
IS  - 111628
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Mätzkow, Malte
A1  - Durán, Marlena Palomar
A1  - Greeff, Anton
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Optimization of the immobilization of bacterial spores on glass substrates with organosilanes
JF  - Physica status solidi (A) : Applications and materials science
N2  - Spores can be immobilized on biosensors to function as sensitive recognition elements. However, the immobilization can affect the sensitivity and reproducibility of the sensor signal. In this work, three different immobilization strategies with organosilanes were optimized and characterized to immobilize Bacillus atrophaeus spores on glass substrates. Five different silanization parameters were investigated: nature of the solvent, concentration of the silane, silanization time, curing process, and silanization temperature. The resulting silane layers were resistant to a buffer solution (e.g., Ringer solution) with a polysorbate (e.g., Tween®80) and sonication.
KW  - silanization
KW  - organosilanes
KW  - immobilization
KW  - endospores
KW  - biosensors
KW  - Bacillus atrophaeus
Y1  - 2016
U6  - http://dx.doi.org/10.1002/pssa.201532914
SN  - 1862-6319
VL  - 213
IS  - 6
SP  - 1463
EP  - 1470
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Oberländer, Jan
A1  - Mätzkow, M.
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Surface functionalization for spore-based biosensors with organosilanes
JF  - Electrochimica Acta
N2  - In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated.
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.electacta.2017.04.157
SN  - 0013-4686
VL  - 241
SP  - 237
EP  - 243
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - A microscopic photometric method for measuring erythrocyte deformability. Artmann, Gerhard Michael
JF  - Clinical Hemorheology. 6 (1986)
Y1  - 1986
SN  - 0271-5198
SP  - 617
EP  - 627
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - 2nd International Conference on Medical Biorheology (ICMB). Shanghai, China, September 13-15, 1995. Shi, Young de, Artmann, Gerhard Michael, Meiselman, Herbert J.
JF  - Biorheology. 33 (1996), H. 6
Y1  - 1996
SN  - 0006-355x
SP  - 505
EP  - 507
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - Microscopic photometric quantification of stiffness and relaxation time of red blood cells in a flow chamber. Artmann, Gerhard Michael
JF  - Biorheology. 32 (1995), H. 5
Y1  - 1995
SN  - 0006-355x
SP  - 553
EP  - 570
ER  - 
TY  - BOOK
A1  - Artmann, Gerhard
T1  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - Cellular engineering - a challenge for engineers? / Artmann, G. M.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 449
ER  - 
TY  - BOOK
A1  - Artmann, Gerhard
T1  - Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.
Y1  - 2011
SN  - 978-3-642-11864-7
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Burns, Laura
A1  - Canaves, Jaume M.
A1  - Temiz Artmann, Aysegül
T1  - Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature
JF  - European Biophysics Journal. 33 (2004), H. 6
Y1  - 2004
SN  - 1432-1017
SP  - 490
EP  - 496
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Bäumler, H.
A1  - Voigt, A.
A1  - Mitlöhner, R. [u.a.]
T1  - Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. Bäumler, H., Artmann, Gerhard Michael; Voigt, A., Mitlöhner, R., Neu, B., Kiesewetter, H.
JF  - Journal of Microencapsulation. 17 (2000), H. 5
Y1  - 2000
SN  - 1464-5246
SP  - 651
EP  - 655
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Linder, Peter
A1  - Porst, Dariusz
T1  - Mechanism of haemoglobin sensing body temperature
JF  - Tissue Engineering Part A. 14 (2008), H. 5
Y1  - 2008
SN  - 1937-3341
N1  - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal
SP  - 754
EP  - 754
ER  - 
TY  - CHAP
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Linder, Peter
A1  - Temiz Artmann, Aysegül
T1  - Biophysical and Engineering Contributions to Plant Research
N2  - Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in–situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves.
KW  - Pflanzenphysiologie
KW  - Dattel
KW  - Pflanzenscanner
KW  - plant scanner
KW  - date palm tree
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Digel, Ilya
A1  - Zerlin, Kay
A1  - Maggakis-Kelemen, Christina
A1  - Linder, Peter
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Stadler, David
A1  - Dikta, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Hemoglobin senses body temperature
JF  - European Biophysics Journal
Y1  - 2009
SN  - 0175-7571
VL  - 38
IS  - 5
SP  - 589
EP  - 600
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Gorbatenkova, E. A.
A1  - Panasenko, O. M.
T1  - Hypochlorous acid and human blood low density lipoproteins modified by hypochlorous acid increase erythrocyte adhesion to endothelial cells. Gorbatenkova, E. A.; Artmann, Gerhard Michael; Panasenko, O. M.
JF  - Membrane and cell biology. 13 (2000), H. 4
Y1  - 2000
SN  - 1023-6597
SP  - 537
EP  - 546
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Grebe, R.
A1  - Homrighausen, A.
A1  - Wolff, H.
A1  - [u.a.], 
T1  - Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Schönbein, H.
JF  - 12. Jahrestagung der Gesellschaft für Mikrozirkulation
Y1  - 1988
SP  - 196
EP  - 200
PB  - Karger [u.a.]
CY  - Basel [u.a.]
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Hovav, T.
A1  - Goldfarb, A.
A1  - Yedgar, S. [u.a.]
T1  - Enhanced adherence of beta-thalassaemic erythrocytes to endothelial cells. Hovav, T., Goldfarb, A.; Artmann, Gerhard Michael, Yedgar, S.; Barstein, G.
JF  - British Journal of Haematology. 106 (1999), H. 1
Y1  - 1999
SN  - 1365-2141
SP  - 178
EP  - 181
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Hueck, I. S.
A1  - Hollweg, H. G.
A1  - Schmid-Schönbein, G. W.
T1  - Chlorpromazine modulates the Morphological Macro- and Microstructure of Endothelial Cells. Hueck, I. S.; Hollweg, H. G.; Schmid-Schönbein, G. W.; Artmann, Gerhard Michael
JF  - American Journal of Physiology. Cell Physiology. 278 (2000), H. 5
Y1  - 2000
SN  - 1522-1563
N1  - Zählung: C873- C878
SP  - 873
EP  - 878
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Hueck, Isgard S.
A1  - Rossiter, Katharine
A1  - Schmid-Schönbein, Geert W.
T1  - Fluid Shear Attenuates Endothelial Pseudopodia Formation into the Capillary Lumen / Hueck, Isgard S. ; Rossiter, Katharine ; Artman, Gerhard M. ; Schmid-Schönbein, Geert W.
JF  - Microcirculation. 15 (2008), H. 6
Y1  - 2008
SN  - 1549-8719
SP  - 531
EP  - 542
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Kelemen, C.
A1  - Chien, S.
T1  - Temperature transition of human hemoglobin at body temperature: effects of calcium. Kelemen, C.; Chien, S.; Artmann, Gerhard Michael
JF  - Biophysical journal. 80 (2001), H. 6
Y1  - 2001
SN  - 1542-0086
SP  - 2622
EP  - 2630
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Kelemen, C.
A1  - Porst, Dariusz
A1  - Büldt, G.
T1  - Cellular engineering: Crash tests an menschlichen Erythrozyten geben Aufschluß über versteckte Materialeigenschaften zellulärer Proteine / Artmann, G. M. ; Kelemen, Ch. ; Porst, D. ; Büldt, G. ; Chien, Shu
JF  - Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1
Y1  - 1998
SN  - 1862-278
SP  - 446
EP  - 447
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Kelemen, Christina
A1  - Porst, Dariusz
A1  - Büldt, G. [u.a.]
T1  - Temperature transitions of protein properties in human red blood cells. Artmann, Gerhard Michael, Kelemen, Christina; Porst, D.; Büldt, G.; Chien, S.
JF  - Biophysical Journal. 75 (1998), H. 6
Y1  - 1998
SN  - 1542-0086
N1  - http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1299989&blobtype=pdf
SP  - 3179
EP  - 3183
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Li, Anlan
T1  - Dihydroergocryptine maintains erythrocyte fluidity in acidotic and hyperosmolar suspensions modelling hypoxic and ischemic microcirculation. Li, Anlan; Artmann, Gerhard Michael
JF  - Clinical Hemorheology. 15 (1994), H. 2
Y1  - 1994
SN  - 0271-5198
SP  - 133
EP  - 146
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Li, Anlan
A1  - Seipelt, H.
A1  - Müller, C. [u.a.]
T1  - Effects of salicylic acid derivatives on red blood cell membranes. Li, Anlan; Seipelt, H.; Müller, C.;Shi, Yong de; Artmann, Gerhard Michael
JF  - Pharmacology and Toxicology. 85 (1999)
Y1  - 1999
SN  - 0902-9938
SP  - 206
EP  - 211
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Li, Anlan
A1  - Ziemer, J.
A1  - Schneider, G. [u.a.]
T1  - A photometric method to analyze induced erythrocyte shape changes. Artmann, Gerhard Michael; Li, Anlan; Ziemer, J.; Schneider, G.; Sahm, U.: ; Ziemer, J.; Schneider, G.; Sahm, U.
JF  - Biorheology. 33 (1996), H. 3
Y1  - 1996
SN  - 0006-355x
SP  - 251
EP  - 265
ER  - 
TY  - PAT
A1  - Artmann, Gerhard
A1  - Linder, Peter
A1  - Bayer, Robin
A1  - Gossmann, Matthias
T1  - Celldrum electrode arrangement for measuring mechanical stress [Patent of invention]
N2  - The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance.
Y1  - 2017
N1  - Patent auch unter EP3403090, CN109477828, US2019033245 und LU92948 veröffentlicht.
PB  - WIPO
CY  - Geneva
ER  - 
TY  - CHAP
A1  - Artmann, Gerhard
A1  - Meruvu, Haritha
A1  - Kizildag, Sefa
A1  - Temiz Artmann, Aysegül
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative “CellDrum technology” was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.
Y1  - 2018
SN  - 978-981-10-7904-7
U6  - http://dx.doi.org/10.1007/978-981-10-7904-7_7
SP  - 157
EP  - 192
PB  - Springer
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Schikarsky, C.
T1  - Ginkgo Biloba extract (EGb 761) protects red blood cells from oxidative damage. Artmann, Gerhard Michael; Schikarsky, C.
JF  - Clinical Hemorheology. 13 (1993), H. 4
Y1  - 1993
SN  - 0271-5198
SP  - 529
EP  - 539
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Schmid-Schönbein, H.
T1  - The microscope-photometrical-monolayer-technique- a new principle for analyzing the distribution of rheological responses in pathological and experimentally modified red cell populations. Artmann, Gerhard Michael; Schmid-Schönbein, H.
JF  - Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987
Y1  - 1987
SN  - 0444809511
N1  - World Congress for Microcirculation (4, 1987, Tokyo;); International congress series ; 755
SP  - 475
EP  - 477
PB  - Excerpta Medica
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Schmid-Schönbein, H.
A1  - Grebe, R.
A1  - Teitel, P. [u.a.]
T1  - Restoration of Microsieve Filterability of Human Red Cells After Exposure to Hyperosmolarity and Lactazidosis: Effect of Vinpocetine. Schmid-Schönbein, H.; Grebe, R.; Teitel, P.; Artmann, Gerhard Michael, Eschweiler, H.; Schröder, Susanne
JF  - Drug Development Research. 14 (1988), H. 3-4
Y1  - 1988
SN  - 1098-2299
N1  - Abstracts frei unter:
SP  - 205
EP  - 211
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Schmid-Schönbein, H.
A1  - Schröder, Susanne
A1  - Grebe, R. [u.a.]
T1  - Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Schönbein, H.; Schröder, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P.
JF  - Arzneimittelforschung. 38 (1988), H. 5
Y1  - 1988
SN  - 0004-4172
SP  - 710
EP  - 716
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Shi, Young de
A1  - Agosti, R.
A1  - Longhini, E.
T1  - A modified casson equation to characterize blood rheology for hypertension. Shi, Young de; Artmann, Gerhard Michael; Agosti, R.; Longhini, E.
JF  - Clinical Hemorheology Microcirculation. 19 (1998), H. 2
Y1  - 1998
SN  - 1386-0291
SP  - 115
EP  - 127
ER  - 
TY  - CHAP
A1  - Artmann, Gerhard
A1  - Stadler, Andreas M.
A1  - Embs, Jan P.
A1  - Zaccai, Giuseppe
A1  - Büldt, Georg
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
T1  - The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]
N2  - The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature
KW  - Hämoglobin
KW  - Erythrozyt
KW  - Körpertemperatur
Y1  - 2010
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Sung, K.-L. Paul
A1  - Horn, Thomas
A1  - Whittemore, Darren [u.a.]
T1  - Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation. Artmann, Gerhard Michael; Sung, K.-L. Paul; Horn, Thomas; Whittemore, Darren; Norwich, Gerald; Chien, Shu
JF  - Biophysical journal. 72 (1997), H. 3
Y1  - 1997
SN  - 1542-0086
SP  - 1434
EP  - 1441
ER  - 
TY  - BOOK
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
A1  - Zhubanova, Azhar A.
A1  - Digel, Ilya
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Biological, physical and technical basics of cell engineering
Y1  - 2018
SN  - 978-981-10-7903-0
PB  - Springer
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Trzewik, J.
A1  - Schmid-Schönbein, G. W.
T1  - Investigation on lymphatic endothelial microvalves / Trzewik, J. ; Artmann, G. M. ; Schmid-Schönbein, G. W.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 521
EP  - 522
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Trzewik, Jürgen
A1  - Ates, M.
T1  - A novel method to quantify mechanical tension in cell monolayers. Trzewik, Jürgen; Ates, M., Artmann, Gerhard Michael
JF  - Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1
Y1  - 2002
SN  - 0013-5585
N1  - Druckausgabe unter 63 Z 47 vorhanden
SP  - 379
EP  - 381
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Trzewik, Jürgen
A1  - Mallipattu, S. K.
A1  - Delano, F. A. [u.a.]
T1  - Evidence for a second valve system in Lymphatics: Endothelial Microvalves. Trzewik, Jürgen; Mallipattu, S. K.; Artmann, Gerhard Michael; Delano, F. A.; Schmid-Schonbein, G. W
JF  - The FASEB Journal. 15 (2001)
Y1  - 2001
SN  - 1530-6860
SP  - 1711
EP  - 1717
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zang, Werner
T1  - Fully automatic measurement of rheologic parameters of red blood cells = Laborautomat zur Messung mechanischer Eigenschaften roter Blutzellen
JF  - Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3
Y1  - 1990
SN  - 0013-5585
SP  - 94
EP  - 96
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Zerlin, Kay
A1  - Digel, Ilya
T1  - Hemoglobin Senses Body Temperature
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 415
EP  - 447
PB  - Springer
CY  - Berlin
ER  -