TY - JOUR A1 - Rieper, Harald A1 - Gebhardt, Andreas A1 - Stucker, Brent T1 - Selective Laser Melting of the Eutectic Silver-Copper Alloy Ag 28 wt % Cu JF - RTejournal - Forum für Rapid Technologie N2 - The aim of this work was to perform a detailed investigation of the use of Selective Laser Melting (SLM) technology to process eutectic silver-copper alloy Ag 28 wt. % Cu (also called AgCu28). The processing occurred with a Realizer SLM 50 desktop machine. The powder analysis (SEM-topography, EDX, particle distribution) was reported as well as the absorption rates for the near-infrared (NIR) spectrum. Microscope imaging showed the surface topography of the manufactured parts. Furthermore, microsections were conducted for the analysis of porosity. The Design of Experiments approach used the response surface method in order to model the statistical relationship between laser power, spot distance and pulse time. KW - SLM KW - Response Surface Method KW - Porositat KW - Eutectic Silver Copper alloy KW - Additive Manufacturing Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?nbn:de:0009-2-44141 SN - 1614-0923 VL - 13 ER - TY - CHAP A1 - Fredebeul-Krein, Markus T1 - Towards trade facilitation via regulatory convergence: An analysis of the TTIP chapter on Electronic Communications T2 - Regional ITS Conference of the International Telecommunications Society. Cambridge, United Kingdom, 7-9 September 2016 N2 - To give the exchange of goods and services between the European Union (EU) and the United States (U.S.) new momentum the two parties are currently negotiating the transatlantic free trade agreement Transatlantic Trade and Investment Partnership (TTIP). The aim is to create the largest free trade area in the world. The agreement, once entered into force, will oblige EU countries and the U.S. to further liberalize their markets. The negotiations on TTIP include a chapter on Electronic Communications/ Telecommunications. The challenge therein will be securing commitments for market access to Electronic Communications services. At the same time, these commitments must reflect the legitimate need for consumer protection issues. The need to reduce Electronic Communications-related non-tariff barriers to trade between the Parties is due to the fact that these markets are heavily regulated. Without transnational rules as to regulations national governments can abuse these regulations to deter the market entry by new (foreign) suppliers. Thus the free trade agreement TTIP affects in many respects regulatory provisions on and access to Electronic Communications markets. The objective of this paper is therefore to examine to what extend the regulatory principles for Electronic Communications markets envisaged under TTIP will result in trade facilitation and regulatory convergence between the EU and the U.S. As to this question the result of the analysis is that the chapter on Electronic Communications will be an important step towards facilitating trade in Electronic Communications services. At the same time some regulatory convergence will take place, but this convergence will not lead to a (full) harmonization of regulations. Rather the norm, also after TTIP negotiations will have been concluded successfully, will be mutual recognition of different regulatory regimes. Different regulations being the optimal policy response in different market settings will continue to exist. Moreover, it is very unlikely that such regulatory principles for the Electronic Communications sector are a vehicle for a race to the bottom in levels of consumer protection. KW - regulation KW - liberalisation KW - electronic communications markets KW - TTIP Y1 - 2016 ER - TY - JOUR A1 - Wagner, Torsten A1 - Vornholt, Wolfgang A1 - Werner, Frederik A1 - Yoshinobu, Tatsuo A1 - Miyamoto, Ko-Ichiro A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening JF - Physics in medicine N2 - The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution. Y1 - 2016 U6 - https://doi.org/10.1016/j.phmed.2016.03.001 SN - 2352-4510 VL - 2016 IS - 1 SP - 2 EP - 7 ER - TY - JOUR A1 - Doll, Theodor A1 - Wagner, Torsten A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Engineering of functional interfaces / Theodor Doll ; Torsten Wagner ; Patrick Wagner ; Michael J. Schöning (eds.) JF - Physica status solidi (a) Y1 - 2016 U6 - https://doi.org/10.1002/pssa.201670641 SN - 1862-6319 VL - 213 IS - 6 SP - 1393 EP - 1394 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Funke, Harald A1 - Keinz, Jan A1 - Börner, S. A1 - Hendrick, P. A1 - Elsing, R. T1 - Testing and analysis of the impact on engine cycle parameters and control system modifications using hydrogen or methane as fuel in an industrial gas turbine T2 - Progress in propulsion physics ; Volume 8 Y1 - 2016 SN - 978-5-94588-191-4 U6 - https://doi.org/10.1051/eucass/201608409 SP - 409 EP - 426 PB - EDP Sciences CY - o.O. ER - TY - JOUR A1 - Ghosch, S. A1 - Baier, M. A1 - Schütz, J. A1 - Schneider, Felix A1 - Scherer, Ulrich W. T1 - Analysis of electronic autoradiographs by mathematical post-processing JF - Radiation Effects and Defects in Solids: Incorporating plasma science and plasma technology N2 - Autoradiography is a well-established method of nuclear imaging. When different radionuclides are present simultaneously, additional processing is needed to distinguish distributions of radionuclides. In this work, a method is presented where aluminium absorbers of different thickness are used to produce images with different cut-off energies. By subtracting images pixel-by-pixel one can generate images representing certain ranges of β-particle energies. The method is applied to the measurement of irradiated reactor graphite samples containing several radionuclides to determine the spatial distribution of these radionuclides within pre-defined energy windows. The process was repeated under fixed parameters after thermal treatment of the samples. The greyscale images of the distribution after treatment were subtracted from the corresponding pre-treatment images. Significant changes in the intensity and distribution of radionuclides could be observed in some samples. Due to the thermal treatment parameters the most significant differences were observed in the ³H and ¹⁴C inventory and distribution. Y1 - 2016 U6 - https://doi.org/10.1080/10420150.2016.1155587 SN - 1029-4953 VL - 171 IS - 1-2 SP - 161 EP - 172 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Broenner, Simon A1 - Höfken, Hans-Wilhelm A1 - Schuba, Marko T1 - Streamlining extraction and analysis of android RAM images T2 - Proceedings of the 2nd international conference on information systems security and privacy Y1 - 2016 SN - 978-989-758-167-0 U6 - https://doi.org/10.5220/0005652802550264 SP - 255 EP - 264 ER - TY - JOUR A1 - Kolditz, Melanie A1 - Albin, Thivaharan A1 - Abel, Dirk A1 - Fasse, Alessandro A1 - Brüggemann, Gert-Peter A1 - Albracht, Kirsten T1 - Evaluation of foot position and orientation as manipulated variables to control external knee adduction moments in leg extension training JF - Computer methods and programs in biomedicine N2 - Background and Objective Effective leg extension training at a leg press requires high forces, which need to be controlled to avoid training-induced damage. In order to avoid high external knee adduction moments, which are one reason for unphysiological loadings on knee joint structures, both training movements and the whole reaction force vector need to be observed. In this study, the applicability of lateral and medial changes in foot orientation and position as possible manipulated variables to control external knee adduction moments is investigated. As secondary parameters both the medio-lateral position of the center of pressure and the frontal-plane orientation of the reaction force vector are analyzed. Methods Knee adduction moments are estimated using a dynamic model of the musculoskeletal system together with the measured reaction force vector and the motion of the subject by solving the inverse kinematic and dynamic problem. Six different foot conditions with varying positions and orientations of the foot in a static leg press are evaluated and compared to a neutral foot position. Results Both lateral and medial wedges under the foot and medial and lateral shifts of the foot can influence external knee adduction moments in the presented study with six healthy subjects. Different effects are observed with the varying conditions: the pose of the leg is changed and the direction and center of pressure of the reaction force vector is influenced. Each effect results in a different direction or center of pressure of the reaction force vector. Conclusions The results allow the conclusion that foot position and orientation can be used as manipulated variables in a control loop to actively control knee adduction moments in leg extension training. KW - External knee adduction moments KW - Manipulated variables KW - Inverse dynamic problem KW - Inverse kinematic problem KW - Musculoskeletal model Y1 - 2016 U6 - https://doi.org/10.1016/j.cmpb.2016.09.005 SN - 0169-2607 N1 - Part of special issue: "SI: Personalised Models and System Identification" VL - 171 SP - 81 EP - 86 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Belavy, Daniel L. A1 - Albracht, Kirsten A1 - Bruggemann, Gert-Peter A1 - Vergroesen, Pieter-Paul A. A1 - Dieen, Jaap H. van T1 - Can exercise positively influence the intervertebral disc? JF - Sports Medicine N2 - To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a ‘critical period’ for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research. KW - Intradiscal Pressure KW - Annulus Fibrosus KW - Disc Degeneration KW - Nucleus Pulposus KW - Intervertebral Disc Y1 - 2016 U6 - https://doi.org/10.1007/s40279-015-0444-2 SN - 1179-2035 VL - 46 IS - 4 SP - 473 EP - 485 PB - Springer CY - Berlin ER - TY - CHAP A1 - Kessler, Julia A1 - Balc, Nicolae A1 - Gebhardt, Andreas T1 - Basic research on lattice structures focused on the strut shape and welding beads T2 - Physics Procedia Y1 - 2016 U6 - https://doi.org/10.1016/j.phpro.2016.08.086 SN - 1875-3884 N1 - Laser Assisted Net Shape Engineering 9th International Conference on Photonic Technologies Proceedings of the LANE 2016 VL - Vol. 83 SP - 833 EP - 838 ER - TY - JOUR A1 - Miyamoto, Ko-Ichiro A1 - Sato, Takuya A1 - Abe, Minami A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices JF - Micromachines N2 - A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement. KW - light-addressable potentiometric sensor KW - plug-based microfluidic device KW - chemical sensor Y1 - 2016 U6 - https://doi.org/10.3390/mi7070111 SN - 2072-666X N1 - This article belongs to the Special Issue "Micro/Nano Devices for Chemical Analysis" VL - 7 IS - 7 SP - 111 PB - MDPI CY - Basel ER - TY - JOUR A1 - Zhang, Jin A1 - Heimbach, Tycho A1 - Scheer, Nico A1 - Barve, Avantika A1 - Li, Wenkui A1 - Lin, Wen A1 - He, Handan T1 - Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4–Humanized Mouse Studies With PBPK Modeling JF - Journal of Pharmaceutical Sciences N2 - NVS123 is a poorly water-soluble protease 56 inhibitor in clinical development. Data from in vitro hepatocyte studies suggested that NVS123 is mainly metabolized by CYP3A4. As a consequence of limited solubility, NVS123 therapeutic plasma exposures could not be achieved even with high doses and optimized formulations. One approach to overcome NVS123 developability issues was to increase plasma exposure by coadministrating it with an inhibitor of CYP3A4 such as ritonavir. A clinical boost effect was predicted by using physiologically based pharmacokinetic (PBPK) modeling. However, initial boost predictions lacked sufficient confidence because a key parameter, fraction of drug metabolized by CYP3A4 (ƒₘCYP3A4), could not be estimated with accuracy on account of disconnects between in vitro and in vivo preclinical data. To accurately estimate ƒₘCYP3A4 in human, an in vivo boost effect study was conducted using CYP3A4-humanized mouse model which showed a 33- to 56-fold exposure boost effect. Using a top-down approach, human ƒₘCYP3A4 for NVS123 was estimated to be very high and included in the human PBPK modeling to support subsequent clinical study design. The combined use of the in vivo boost study in CYP3A4-humanized mouse model mice along with PBPK modeling accurately predicted the clinical outcome and identified a significant NVS123 exposure boost (∼42-fold increase) with ritonavir. Y1 - 2016 U6 - https://doi.org/doi.org/10.1016/j.xphs.2016.01.021 SN - 0022-3549 VL - Volume 105 IS - Issue 4 SP - 1398 EP - 1404 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Rieper, Harald A1 - Gebhardt, Andreas A1 - Stucker, Brent T1 - Process parameters for Selective Laser Melting of AgCu7 T2 - DDMC, Fraunhofer Direct Digital Manufacturing Conference, 3 Y1 - 2016 SN - 978-3-8396-1001-5 N1 - DDMC, 2016, Fraunhofer Direct Digital Manufacturing Conference, 3rd, Berlin, DE, 2016-03-16 - 2016-03-17 SP - 171 EP - 176 PB - Fraunhofer-Verlag CY - Stuttgart ER - TY - JOUR A1 - Dallas, Shannon A1 - Salphati, Laurent A1 - Gomez-Zepeda, David A1 - Wanek, Thomas A1 - Chen, Liangfu A1 - Chu, Xiaoyan A1 - Kunta, Jeevan A1 - Mezler, Mario A1 - Menet, Marie-Claude A1 - Chasseigneaux, Stephanie A1 - Declèves, Xavier A1 - Langer, Oliver A1 - Pierre, Esaie A1 - DiLoreto, Karen A1 - Hoft, Carolin A1 - Laplanche, Loic A1 - Pang, Jodie A1 - Pereira, Tony A1 - Andonian, Clara A1 - Simic, Damir A1 - Rode, Anja A1 - Yabut, Jocelyn A1 - Zhang, Xiaolin A1 - Scheer, Nico T1 - Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model JF - Molecular Pharmacology N2 - Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp−/−) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP. Y1 - 2016 U6 - https://doi.org/10.1124/mol.115.102079 SN - 1521-0111 VL - 89 IS - 5 SP - 492 EP - 504 PB - ASPET CY - Bethesda, Md. ER - TY - JOUR A1 - Scheer, Nico A1 - Wilson, Ian D. T1 - A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity JF - Drug Discovery Today N2 - Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug–drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives. Y1 - 2016 U6 - https://doi.org/10.1016/j.drudis.2015.09.002 SN - 1359-6446 VL - 21 IS - 2 SP - 250 EP - 263 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Scheer, Nico A1 - Chu, Xiaoyan A1 - Salphati, Laurent A1 - Zamek-Gliszczynski, Maciej J. ED - Nicholls, Glynis T1 - Knockout and humanized animal models to study membrane transporters in drug development T2 - Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development Y1 - 2016 SN - 978-1-78262-379-3 U6 - https://doi.org/10.1039/9781782623793-00298 SP - 298 EP - 332 PB - Royal Society of Chemistry CY - Cambridge ER - TY - CHAP A1 - Wu, Ziyi A1 - Kemper, Hans T1 - The optimal 48 V – battery pack for a specific load profile of a heavy duty vehicle T2 - 8. Internationale Fachtagung Kraftwerk Batterie : 26. – 27. April 2016, Münster, Deutschland Y1 - 2016 ER - TY - CHAP A1 - Neu, Eugen A1 - Janser, Frank A1 - Khatibi, Akbar A. A1 - Orifici, Adrian C. T1 - In-flight vibration-based structural health monitoring of aircraft wings T2 - 30th Congress of the internatonal council of the aeronautical sciences : 25.-30. September 2016, Daejeon, Korea N2 - This work presents a methodology for automated damage-sensitive feature extraction and anomaly detection under multivariate operational variability for in-flight assessment of wings. The method uses a passive excitation approach, i. e. without the need for artificial actuation. The modal system properties (natural frequencies and damping ratios) are used as damage-sensitive features. Special emphasis is placed on the use of Fiber Bragg Grating (FBG) sensing technology and the consideration of Operational and Environmental Variability (OEV). Measurements from a wind tunnel investigation with a composite cantilever equipped with FBG and piezoelectric sensors are used to successfully detect an impact damage. In addition, the feasibility of damage localisation and severity estimation is evaluated based on the coupling found between damageand OEV-induced feature changes. Y1 - 2016 ER - TY - CHAP A1 - Barnat, Miriam A1 - Bosse, Elke T1 - The challenge of creating meta-inferences: Combining data representing institutional and individual perspectives on first-year support in higher education T2 - 9th Conference on Social Science Methodology of the International Sociological Association, Leicester, UK Y1 - 2016 N1 - RC33 Conference 2016 SP - 1 EP - 20 ER - TY - CHAP A1 - Kleine, Harald A1 - Kallweit, Stephan A1 - Michaux, Frank A1 - Havermann, Marc A1 - Olivier, Herbert T1 - PIV Measurement of Shock Wave Diffraction T2 - 18th International Symposium on Applications of Laser Techniques to Fluid Mechanics, 2016, Lissabon Y1 - 2016 SP - 1 EP - 14 ER - TY - CHAP A1 - Schleupen, Josef A1 - Engemann, Heiko A1 - Bagheri, Mohsen A1 - Kallweit, Stephan T1 - The potential of SMART climbing robot combined with a weatherproof cabin for rotor blade maintenance T2 - 17th European Conference on Composite Materials – ECCM, Munich, Germany Y1 - 2016 N1 - ECCM 17 SP - 1 EP - 8 ER - TY - JOUR A1 - Paulßen, Elisabeth A1 - Lengkeek, Nigel A. A1 - Le, Van So A1 - Pellegrini, Paul A. A1 - Greguric, Ivan A1 - Weiner, Ron T1 - The role of additives in moderating the influence of Fe(III) and Cu(II) on the radiochemical yield of [⁶⁸Ga(DOTATATE)] JF - Applied Radiation and Isotopes N2 - [⁶⁸Ga(DOTATATE)] has demonstrated its clinical usefulness. Both Fe³⁺ and Cu²⁺, potential contaminants in Gallium-68 generator eluent, substantially reduce the radiochemical (RC) yield of [⁶⁸Ga(DOTATATE)] if the metal/ligand ratio of 1:1 is exceeded. A variety of compounds were examined for their potential ability to reduce this effect. Most had no effect on RC yield. However, addition of phosphate diminished the influence of Fe³⁺ by likely forming an insoluble iron salt. Addition of ascorbic acid reduced Cu²⁺ and Fe³⁺ to Cu⁺ and Fe²⁺ respectively, both of which have limited impact on RC yields. At low ligand amounts (5 nmol DOTATATE), the addition of 30 nmol phosphate (0.19 mM) increased the tolerance of Fe3⁺ from 4 nmol to 10 nmol (0.06 mM), while the addition of ascorbic acid allowed high RC yields (>95%) in the presence of 40 nmol Fe³⁺ (0.25 mM) and 100 nmol Cu²⁺ (0.63 mM). The effect of ascorbic acid was highly pH-dependant, and gave optimal results at pH 3. Y1 - 2016 U6 - https://doi.org/10.1016/j.apradiso.2015.09.008 SN - 1872-9800 VL - 107 SP - 13 EP - 16 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Infantino, Angelo A1 - Paulßen, Elisabeth A1 - Mostacci, Domiziano A1 - Schaffer, Paul A1 - Trinczek, Michael A1 - Hoehr, Cornelia T1 - Assessment of the production of medical isotopes using the Monte Carlo code FLUKA: Simulations against experimental measurements JF - Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms N2 - The Monte Carlo code FLUKA is used to simulate the production of a number of positron emitting radionuclides, ¹⁸F, ¹³N, ⁹⁴Tc, ⁴⁴Sc, ⁶⁸Ga, ⁸⁶Y, ⁸⁹Zr, ⁵²Mn, ⁶¹Cu and ⁵⁵Co, on a small medical cyclotron with a proton beam energy of 13 MeV. Experimental data collected at the TR13 cyclotron at TRIUMF agree within a factor of 0.6 ± 0.4 with the directly simulated data, except for the production of ⁵⁵Co, where the simulation underestimates the experiment by a factor of 3.4 ± 0.4. The experimental data also agree within a factor of 0.8 ± 0.6 with the convolution of simulated proton fluence and cross sections from literature. Overall, this confirms the applicability of FLUKA to simulate radionuclide production at 13 MeV proton beam energy. Y1 - 2016 U6 - https://doi.org/10.1016/j.nimb.2015.10.067 SN - 1872-9584 VL - 366 SP - 117 EP - 123 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Wilke, Thomas ED - Merlotti, Andrea T1 - Planning Process of the Di Castellamonte’s Chapel of the Holy Shroud T2 - Carlo e Amedeo di Castellamonte : 1571-1683, ingegneri e architetti per i duchi di Savoia Y1 - 2016 SN - 978-88-98229-57-4 N1 - Architettura e potere ; 4 SP - 141 EP - 152 PB - Campisano editore CY - Rom ER - TY - JOUR A1 - Bernecker, Andreas T1 - Divided we reform? Evidence from US welfare policies JF - Journal of Public Economics N2 - Divided government is often thought of as causing legislative deadlock. I investigate the link between divided government and economic reforms using a novel data set on welfare reforms in US states between 1978 and 2010. Panel data regressions show that, under divided government, a US state is around 25% more likely to adopt a welfare reform than under unified government. Several robustness checks confirm this counter-intuitive finding. Case study evidence suggests an explanation based on policy competition between governor, senate, and house. Y1 - 2016 U6 - https://doi.org/10.1016/j.jpubeco.2016.08.003 SN - 0047-2727 VL - 142 SP - 24 EP - 38 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Matcha, Heike ED - Herneoja, Aulikki ED - Österlund, Toni ED - Markkanen, Piia T1 - From Designing Buildings from Systems to Designing Systems for Buildings T2 - Complexity & Simplicity - Proceedings of the 34th eCAADe Conference - Volume 1 N2 - We study the novel possibilities computer aided design and production open up for the design of building systems. Such systems today can, via individualized mass production, consist of a larger number and more complex parts than previously and therefore be assembled into more complex wholes. This opens up the possibility of designing specialized systems specifically for single buildings. The common order of starting with a building system and designing a building using this system can be reversed to designing a building first and then developing a system specifically for that building. We present and discuss research that incorporates students design projects into research work and fosters links between research and teaching. KW - Building Systems KW - Parametric Design KW - Parametric Modelling KW - Structuralist Architecture Y1 - 2016 U6 - https://doi.org/10.52842/conf.ecaade.2016.1.237 N1 - Proceedings of the 34th eCAADe Conference, University of Oulu, Oulu, Finland, 22-26 August 2016. SP - 237 EP - 240 PB - ECAADe CY - Oulu, Finland ER - TY - CHAP A1 - Rausch, Lea A1 - Leise, Philipp A1 - Ederer, Thorsten A1 - Altherr, Lena A1 - Pelz, Peter F. ED - Papadrakakis, M. ED - Ppadopoulos, V. ED - Stefanou, G. ED - Plevris, V. T1 - A comparison of MILP and MINLP solver performance on the example of a drinking water supply system design problem T2 - ECCOMAS Congress 2016 VII European Congress on Computational Methods in Applied Sciences and Engineering N2 - Finding a good system topology with more than a handful of components is a highly non-trivial task. The system needs to be able to fulfil all expected load cases, but at the same time the components should interact in an energy-efficient way. An example for a system design problem is the layout of the drinking water supply of a residential building. It may be reasonable to choose a design of spatially distributed pumps which are connected by pipes in at least two dimensions. This leads to a large variety of possible system topologies. To solve such problems in a reasonable time frame, the nonlinear technical characteristics must be modelled as simple as possible, while still achieving a sufficiently good representation of reality. The aim of this paper is to compare the speed and reliability of a selection of leading mathematical programming solvers on a set of varying model formulations. This gives us empirical evidence on what combinations of model formulations and solver packages are the means of choice with the current state of the art. KW - Technical Operations Research KW - Mixed-Integer Nonlinear Optimisation KW - Solver Per- formance KW - Drinking Water Supply KW - System Design Problem Y1 - 2016 SN - 978-618-82844-0-1 N1 - ECCOMAS Congress 2016 VII European Congress on Computational Methods in Applied Sciences and Engineering, 5–10 June 2016.Crete Island, Greece SP - 8509 EP - 8527 ER - TY - BOOK A1 - Altherr, Lena T1 - Algorithmic System Design under Consideration of Dynamic Processes N2 - Nach Stand von Wissenschaft und Technik werden Komponenten hinsichtlich ihrer Eigenschaften, wie Lebensdauer oder Energieeffizienz, optimiert. Allerdings können selbst hervorragende Komponenten zu ineffizienten oder instabilen Systemen führen, wenn ihr Zusammenspiel nur unzureichend berücksichtigt wird. Eine Systembetrachtung schafft ein größeres Optimierungspotential - dem erhöhten Potential steht jedoch auch ein erhöhter Komplexitätsgrad gegenüber. Die vorliegende Arbeit ist im Rahmen des Sonderforschungsbereichs 805 entstanden, dessen Ziel die Beherrschung von Unsicherheit in Systemen des Maschinenbaus ist. Die Arbeit zeigt anhand eines realen Systems aus dem Bereich der Hydraulik, wie Unsicherheit in der Entwicklungsphase beherrscht werden kann. Hierbei ist neu, dass die durch den späteren Betrieb zu erwartende Systemdegradation eines jeden möglichen Systemvorschlags antizipiert werden kann. Dadurch können Betriebs- und Wartungskosten vorausgesagt und minimiert werden und durch eine optimale Betriebs- und Wartungsstrategie die Verfügbarkeit des Systems garantiert werden. Wesentliche Fragen bei der optimalen Auslegung des betrachteten hydrostatischen Getriebes sind dessen physikalische Modellierung, die Darstellung des Optimierungsproblems als gemischt-ganzzahliges lineares Programm, und dessen algorithmische Behandlung zur Lösungsfindung. Hierzu werden Heuristiken zum schnelleren Auffinden sinnvoller Systemtopologien vorgestellt und mittels mathematischer Dekomposition eine Bewertung des dynamischen Verschleiß- und Wartungsverlaufs möglicher Systemvorschläge vorgenommen. Die Arbeit stellt die Optimierung technischer Systeme an der Schnittstelle von Mathematik, Informatik und Ingenieurwesen sowohl gründlich als auch anschaulich und nachvollziehbar dar. KW - Mixed Integer Programming KW - Technical Operations Research KW - Optimization KW - System Design Y1 - 2016 SN - 978-3-8440-4848-3 PB - Shaker CY - Aachen ER - TY - CHAP A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Lorenz, Ulf A1 - Pelz, Peter F. A1 - Pöttgen, Philipp ED - Lübbecke, Marco E. ED - Koster, Arie ED - Letmathe, Peter ED - Madlener, Reihard ED - Preis, Britta ED - Walther, Grit T1 - Designing a feedback control system via mixed-integer programming T2 - Operations Research Proceedings 2014: Selected Papers of the Annual International Conference of the German Operations Research N2 - Pure analytical or experimental methods can only find a control strategy for technical systems with a fixed setup. In former contributions we presented an approach that simultaneously finds the optimal topology and the optimal open-loop control of a system via Mixed Integer Linear Programming (MILP). In order to extend this approach by a closed-loop control we present a Mixed Integer Program for a time discretized tank level control. This model is the basis for an extension by combinatorial decisions and thus for the variation of the network topology. Furthermore, one is able to appraise feasible solutions using the global optimality gap. KW - Optimal Topology KW - Controller Parameter KW - Level Control System KW - Technical Operation Research KW - Optimal Closed Loop Y1 - 2016 SN - 978-3-319-28695-2 U6 - https://doi.org/10.1007/978-3-319-28697-6_18 SP - 121 EP - 127 PB - Springer CY - Cham ER - TY - CHAP A1 - Nursinski-Stolberg, André A1 - Gangatharan, Kiritharan A1 - Czarnecki, Christian ED - Mayr, Heinrich C. ED - Pinzger, Martin T1 - Development of a subject-oriented reference process model for the telecommunications industry T2 - GI Edition Proceedings Band 259 INFORMATIK 2016 N2 - Generally the usage of reference models can be structured top-down or bottom-up. The practical need of agile change and flexible organizational implementation requires a consistent mapping to an operational level. In this context, well-established reference process models are typically structured top-down. The subject-oriented Business Process Management (sBPM) offers a modeling concept that is structured bottom-up and concentrates on the process actors on an operational level. This paper applies sBPM to the enhanced Telecom Operations Map (eTOM), a well-accepted reference process model in the telecommunications industry. The resulting design artifact is a concrete example for a combination of a bottom-up and top-down developed reference model. The results are evaluated and confirmed in practical context through the involvement of the industry body TMForum. KW - Subject-oriented Business Process Management KW - Reference Process Model KW - eTOM KW - Telecommunications Industry. Y1 - 2016 SN - 9783885796534 SN - 1617-5468 N1 - 26.-30. September 2016, Klagenfurt. SP - 699 EP - 712 PB - Gesellschaft für Informatik e.V. CY - Bonn ER - TY - JOUR A1 - Koster, Arie A1 - Scheidweiler, Robert A1 - Tieves, Martin T1 - A flow based pruning scheme for enumerative equitable coloring algorithms JF - A flow based pruning scheme for enumerative equitable coloring algorithms N2 - An equitable graph coloring is a proper vertex coloring of a graph G where the sizes of the color classes differ by at most one. The equitable chromatic number is the smallest number k such that G admits such equitable k-coloring. We focus on enumerative algorithms for the computation of the equitable coloring number and propose a general scheme to derive pruning rules for them: We show how the extendability of a partial coloring into an equitable coloring can be modeled via network flows. Thus, we obtain pruning rules which can be checked via flow algorithms. Computational experiments show that the search tree of enumerative algorithms can be significantly reduced in size by these rules and, in most instances, such naive approach even yields a faster algorithm. Moreover, the stability, i.e., the number of solved instances within a given time limit, is greatly improved. Since the execution of flow algorithms at each node of a search tree is time consuming, we derive arithmetic pruning rules (generalized Hall-conditions) from the network model. Adding these rules to an enumerative algorithm yields an even larger runtime improvement. Y1 - 2016 U6 - https://doi.org/10.48550/arXiv.1607.08754 N1 - Lehrstuhl II für Mathematik, RWTH Aachen University SP - 1 EP - 30 ER - TY - JOUR A1 - Beckenbach, Isabel A1 - Scheidweiler, Robert T1 - Perfect ƒ-Matchings and ƒ-Factors in Hypergraphs - A Combinatorial Approach JF - Discrete Mathematics N2 - We prove characterizations of the existence of perfect ƒ-matchings in uniform mengerian and perfect hypergraphs. Moreover, we investigate the ƒ-factor problem in balanced hypergraphs. For uniform balanced hypergraphs we prove two existence theorems with purely combinatorial arguments, whereas for non-uniform balanced hypergraphs we show that the ƒ-factor problem is NP-hard. Y1 - 2016 U6 - https://doi.org/10.1016/j.disc.2017.05.005 SN - 2192-7782 N1 - Als Volltext auch bei ZIB (Zuse Institute Berlin) VL - 240 IS - 10 SP - 2499 EP - 2506 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Scheidweiler, Robert A1 - Triesch, Eberhard T1 - A note on the duality between matchings and vertex covers in balanced hypergraphs JF - Journal of Combinatorial Optimization N2 - We present a new Min-Max theorem for an optimization problem closely connected to matchings and vertex covers in balanced hypergraphs. The result generalizes Kőnig’s Theorem (Berge and Las Vergnas in Ann N Y Acad Sci 175:32–40, 1970; Fulkerson et al. in Math Progr Study 1:120–132, 1974) and Hall’s Theorem (Conforti et al. in Combinatorica 16:325–329, 1996) for balanced hypergraphs. KW - Hall’s Theorem KW - Koenig’s Theorem KW - Duality KW - Balanced hypergraph KW - Hypergraph KW - Vertex cover KW - Matching Y1 - 2016 U6 - https://doi.org/10.1007/s10878-015-9887-5 SN - 1573-2886 N1 - Lehrstuhl II für Mathematik RWTH Aachen VL - 32 IS - 2 SP - 639 EP - 644 PB - Springer CY - Berlin ER - TY - JOUR A1 - Niedermeyer, Angela A1 - Zhou, Bei A1 - Dursun, Gözde A1 - Temiz Artmann, Aysegül A1 - Markert, Bernd T1 - An examination of tissue engineered scaffolds in a bioreactor JF - Proceedings in Applied Mathematics and Mechanics PAMM N2 - Replacement tissues, designed to fill in articular cartilage defects, should exhibit the same properties as the native material. The aim of this study is to foster the understanding of, firstly, the mechanical behavior of the material itself and, secondly, the influence of cultivation parameters on cell seeded implants as well as on cell migration into acellular implants. In this study, acellular cartilage replacement material is theoretically, numerically and experimentally investigated regarding its viscoelastic properties, where a phenomenological model for practical applications is developed. Furthermore, remodeling and cell migration are investigated. Y1 - 2016 U6 - https://doi.org/10.1002/pamm.201610038 SN - 1617-7061 N1 - Joint Annual Meeting of DMV and GAMM 2016, 87th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM) and Deutsche Mathematiker-Vereinigung (DMV), Braunschweig, DE, Mar 7-11, 2016 VL - 16 IS - 1 SP - 99 EP - 100 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Hoeveler, Bastian A1 - Janser, Frank T1 - The aerodynamically optimized design of a fan-in-wing duct T2 - Applied Aerodynamics Research Conference 2016, Bristol, GB, Jul 19-21, 2016 Y1 - 2016 SN - 1-85768-371-4 N1 - G1-3-paper.pdf SP - 1 EP - 10 ER - TY - CHAP A1 - Otten, D. A1 - Schmidt, M. A1 - Weber, Tobias T1 - Advances in Determination of Material Parameters for Functional Simulations Based on Process Simulations T2 - SAMPE Europe Conference 16 Liege Y1 - 2016 SN - 978-1-5108-3800-0 SP - 570 EP - 577 ER - TY - CHAP A1 - Weber, Tobias A1 - Tellis, Jane J. A1 - Duhovic, Miro T1 - Characterization of tool-part-interaction an interlaminar friction for manufacturing process simulation T2 - ECCM 17, 17th European Conference on Composite Materials, München, DE, Jun 26-30, 2016 Y1 - 2016 SN - 978-3-00-053387-7 SP - 1 EP - 7 ER - TY - JOUR A1 - Weber, Tobias A1 - Arent, Jan-Christoph A1 - Münch, Lukas A1 - Duhovic, Miro A1 - Balvers, Johannes M. T1 - A fast method for the generation of boundary conditions for thermal autoclave simulation JF - Composites Part A N2 - Manufacturing process simulation enables the evaluation and improvement of autoclave mold concepts early in the design phase. To achieve a high part quality at low cycle times, the thermal behavior of the autoclave mold can be investigated by means of simulations. Most challenging for such a simulation is the generation of necessary boundary conditions. Heat-up and temperature distribution in an autoclave mold are governed by flow phenomena, tooling material and shape, position within the autoclave, and the chosen autoclave cycle. This paper identifies and summarizes the most important factors influencing mold heat-up and how they can be introduced into a thermal simulation. Thermal measurements are used to quantify the impact of the various parameters. Finally, the gained knowledge is applied to develop a semi-empirical approach for boundary condition estimation that enables a simple and fast thermal simulation of the autoclave curing process with reasonably high accuracy for tooling optimization. Y1 - 2016 U6 - https://doi.org/10.1016/j.compositesa.2016.05.036 SN - 1359-835X VL - 88 SP - 216 EP - 225 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Svaneborg, Carsten A1 - Karimi-Varzaneh, Hossein Ali A1 - Hojdis, Nils A1 - Fleck, Franz A1 - Everaers, Ralf T1 - Multiscale approach to equilibrating model polymer melts JF - Physical Review E N2 - We present an effective and simple multiscale method for equilibrating Kremer Grest model polymer melts of varying stiffness. In our approach, we progressively equilibrate the melt structure above the tube scale, inside the tube and finally at the monomeric scale. We make use of models designed to be computationally effective at each scale. Density fluctuations in the melt structure above the tube scale are minimized through a Monte Carlo simulated annealing of a lattice polymer model. Subsequently the melt structure below the tube scale is equilibrated via the Rouse dynamics of a force-capped Kremer-Grest model that allows chains to partially interpenetrate. Finally the Kremer-Grest force field is introduced to freeze the topological state and enforce correct monomer packing. We generate 15 melts of 500 chains of 10.000 beads for varying chain stiffness as well as a number of melts with 1.000 chains of 15.000 monomers. To validate the equilibration process we study the time evolution of bulk, collective, and single-chain observables at the monomeric, mesoscopic, and macroscopic length scales. Extension of the present method to longer, branched, or polydisperse chains, and/or larger system sizes is straightforward. Y1 - 2016 U6 - https://doi.org/10.1103/PhysRevE.94.032502 SN - 2470-0053 VL - 94 IS - 032502 PB - AIP Publishing CY - Melville, NY ER - TY - JOUR A1 - Schwab, Lukas A1 - Hojdis, Nils A1 - Lacayo, Jorge A1 - Wilhelm, Manfred T1 - Fourier-Transform Rheology of Unvulcanized, Carbon Black Filled Styrene Butadiene Rubber JF - Macromolecular Materials and Engineering N2 - Rubber materials filled with reinforcing fillers display nonlinear rheological behavior at small strain amplitudes below γ0 < 0.1. Nevertheless, rheological data are analyzed mostly in terms of linear parameters, such as shear moduli (G′, G″), which loose their physical meaning in the nonlinear regime. In this work styrene butadiene rubber filled with carbon black (CB) under large amplitude oscillatory shear (LAOS) is analyzed in terms of the nonlinear parameter I3/1. Three different CB grades are used and the filler load is varied between 0 and 70 phr. It is found that I3/1(φ) is most sensitive to changes of the total accessible filler surface area at low strain amplitudes (γ0 = 0.32). The addition of up to 70 phr CB leads to an increase of I3/1(φ) by a factor of more than ten. The influence of the measurement temperature on I3/1 is pronounced for CB levels above the percolation threshold. Y1 - 2016 U6 - https://doi.org/10.1002/mame.201500356 SN - 1439-2054 VL - 301 IS - 4 SP - 457 EP - 468 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Harish, Ajay B. A1 - Wriggers, Peter A1 - Jungk, Juliane A1 - Hojdis, Nils A1 - Recker, Carla T1 - Mesoscale Constitutive Modeling of Non-Crystallizing Filled Elastomers JF - Computational Mechanics N2 - Elastomers are exceptional materials owing to their ability to undergo large deformations before failure. However, due to their very low stiffness, they are not always suitable for industrial applications. Addition of filler particles provides reinforcing effects and thus enhances the material properties that render them more versatile for applications like tyres etc. However, deformation behavior of filled polymers is accompanied by several nonlinear effects like Mullins and Payne effect. To this day, the physical and chemical changes resulting in such nonlinear effect remain an active area of research. In this work, we develop a heterogeneous (or multiphase) constitutive model at the mesoscale explicitly considering filler particle aggregates, elastomeric matrix and their mechanical interaction through an approximate interface layer. The developed constitutive model is used to demonstrate cluster breakage, also, as one of the possible sources for Mullins effect observed in non-crystallizing filled elastomers. Y1 - 2016 U6 - https://doi.org/10.1007/s00466-015-1251-1 SN - 1432-0924 VL - 57 SP - 653 EP - 677 PB - Springer CY - Berlin ER - TY - JOUR A1 - Jahnke, Siegfried A1 - Roussel, Johanna A1 - Hombach, Thomas A1 - Kochs, Johannes A1 - Fischbach, Andreas A1 - Huber, Gregor A1 - Scharr, Hanno T1 - phenoSeeder - A robot system for automated handling and phenotyping of individual seeds JF - Plant physiology N2 - The enormous diversity of seed traits is an intriguing feature and critical for the overwhelming success of higher plants. In particular, seed mass is generally regarded to be key for seedling development but is mostly approximated by using scanning methods delivering only two-dimensional data, often termed seed size. However, three-dimensional traits, such as the volume or mass of single seeds, are very rarely determined in routine measurements. Here, we introduce a device named phenoSeeder, which enables the handling and phenotyping of individual seeds of very different sizes. The system consists of a pick-and-place robot and a modular setup of sensors that can be versatilely extended. Basic biometric traits detected for individual seeds are two-dimensional data from projections, three-dimensional data from volumetric measures, and mass, from which seed density is also calculated. Each seed is tracked by an identifier and, after phenotyping, can be planted, sorted, or individually stored for further evaluation or processing (e.g. in routine seed-to-plant tracking pipelines). By investigating seeds of Arabidopsis (Arabidopsis thaliana), rapeseed (Brassica napus), and barley (Hordeum vulgare), we observed that, even for apparently round-shaped seeds of rapeseed, correlations between the projected area and the mass of seeds were much weaker than between volume and mass. This indicates that simple projections may not deliver good proxies for seed mass. Although throughput is limited, we expect that automated seed phenotyping on a single-seed basis can contribute valuable information for applications in a wide range of wild or crop species, including seed classification, seed sorting, and assessment of seed quality. Y1 - 2016 U6 - https://doi.org/10.1104/pp.16.01122 SN - 0032-0889 VL - 172 IS - 3 SP - 1358 EP - 1370 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Wrede, Oliver T1 - Continuity in travel information JF - Information Design Journal N2 - This article discusses the contrast between the information transportation companies provide to travellers and that of their brand messaging. Companies’ brand messaging often portrays the service they provide as pleasant, stress free and perfect. Customers and users of the service, on the other hand, often describe their experience of the service as a negative one. This article suggests that the brand value would be greater if transportation companies paid more attention to the users’ experience when designing their information systems, particularly in worst case scenarios. Y1 - 2016 U6 - https://doi.org/10.1075/idj.22.2.09wre SN - 0142-5471 N1 - Gedruckt vorhanden in der Bereichsbibliothek Boxgraben unter 53 Z 971-2016 (Magazin) VL - 22 IS - 2 SP - 172 EP - 178 PB - John Benjamins CY - Amsterdam ER - TY - JOUR A1 - Funke, Harald A1 - Keinz, Jan A1 - Kusterer, Karsten A1 - Ayed, Anis Haj A1 - Kazari, Masahide A1 - Kitajima, Junichi A1 - Horikawa, Atsushi A1 - Okada, Kunio T1 - Experimental and Numerical Study on Optimizing the Dry Low NOₓ Micromix Hydrogen Combustion Principle for Industrial Gas Turbine Applications JF - Journal of Thermal Science and Engineering Applications N2 - Combined with the use of renewable energy sources for its production, hydrogen represents a possible alternative gas turbine fuel for future low-emission power generation. Due to the difference in the physical properties of hydrogen compared to other fuels such as natural gas, well-established gas turbine combustion systems cannot be directly applied to dry low NOₓ (DLN) hydrogen combustion. The DLN micromix combustion of hydrogen has been under development for many years, since it has the promise to significantly reduce NOₓ emissions. This combustion principle for air-breathing engines is based on crossflow mixing of air and gaseous hydrogen. Air and hydrogen react in multiple miniaturized diffusion-type flames with an inherent safety against flashback and with low NOₓ emissions due to a very short residence time of the reactants in the flame region. The paper presents an advanced DLN micromix hydrogen application. The experimental and numerical study shows a combustor configuration with a significantly reduced number of enlarged fuel injectors with high-thermal power output at constant energy density. Larger fuel injectors reduce manufacturing costs, are more robust and less sensitive to fuel contamination and blockage in industrial environments. The experimental and numerical results confirm the successful application of high-energy injectors, while the DLN micromix characteristics of the design point, under part-load conditions, and under off-design operation are maintained. Atmospheric test rig data on NOₓ emissions, optical flame-structure, and combustor material temperatures are compared to numerical simulations and show good agreement. The impact of the applied scaling and design laws on the miniaturized micromix flamelets is particularly investigated numerically for the resulting flow field, the flame-structure, and NOₓ formation. Y1 - 2016 U6 - https://doi.org/10.1115/1.4034849 SN - 1948-5093 N1 - TSEA-15-1227 VL - 9 IS - 2 SP - 021001 EP - 021001-10 PB - ASME CY - New York, NY ER - TY - JOUR A1 - Ayed, Anis Haj A1 - Kusterer, Karsten A1 - Funke, Harald A1 - Keinz, Jan T1 - CFD Based Improvement of the DLN Hydrogen Micromix Combustion Technology at Increased Energy Densities JF - American Scientific Research Journal for Engineering, Technology, and Sciences (ASRJETS) N2 - Combined with the use of renewable energy sources for its production, Hydrogen represents a possible alternative gas turbine fuel within future low emission power generation. Due to the large difference in the physical properties of Hydrogen compared to other fuels such as natural gas, well established gas turbine combustion systems cannot be directly applied for Dry Low NOx (DLN) Hydrogen combustion. Thus, the development of DLN combustion technologies is an essential and challenging task for the future of Hydrogen fuelled gas turbines. The DLN Micromix combustion principle for hydrogen fuel has been developed to significantly reduce NOx-emissions. This combustion principle is based on cross-flow mixing of air and gaseous hydrogen which reacts in multiple miniaturized diffusion-type flames. The major advantages of this combustion principle are the inherent safety against flash-back and the low NOx-emissions due to a very short residence time of reactants in the flame region of the micro-flames. The Micromix Combustion technology has been already proven experimentally and numerically for pure Hydrogen fuel operation at different energy density levels. The aim of the present study is to analyze the influence of different geometry parameter variations on the flame structure and the NOx emission and to identify the most relevant design parameters, aiming to provide a physical understanding of the Micromix flame sensitivity to the burner design and identify further optimization potential of this innovative combustion technology while increasing its energy density and making it mature enough for real gas turbine application. The study reveals great optimization potential of the Micromix Combustion technology with respect to the DLN characteristics and gives insight into the impact of geometry modifications on flame structure and NOx emission. This allows to further increase the energy density of the Micromix burners and to integrate this technology in industrial gas turbines. Y1 - 2016 SN - 2313-4402 VL - 26 IS - 3 SP - 290 EP - 303 PB - GSSRR ER - TY - JOUR A1 - Orzada, Stephan A1 - Ladd, Mark E. A1 - Bitz, Andreas T1 - A method to approximate maximum local SAR in multichannel transmit MR systems without transmit phase information JF - Magnetic Resonance in Medicine N2 - Purpose To calculate local specific absorption rate (SAR) correctly, both the amplitude and phase of the signal in each transmit channel have to be known. In this work, we propose a method to derive a conservative upper bound for the local SAR, with a reasonable safety margin without knowledge of the transmit phases of the channels. Methods The proposed method uses virtual observation points (VOPs). Correction factors are calculated for each set of VOPs that prevent underestimation of local SAR when the VOPs are applied with the correct amplitudes but fixed phases. Results The proposed method proved to be superior to the worst-case calculation based on the maximum eigenvalue of the VOPs. The mean overestimation for six coil setups could be reduced, whereas no underestimation of the maximum local SAR occurred. In the best investigated case, the overestimation could be reduced from a factor of 3.3 to a factor of 1.7. Conclusion The upper bound for the local SAR calculated with the proposed method allows a fast estimation of the local SAR based on power measurements in the transmit channels and facilitates SAR monitoring in systems that do not have the capability to monitor transmit phases Y1 - 2016 U6 - https://doi.org/10.1002/mrm.26398 SN - 1522-2594 VL - 78 IS - 2 SP - 805 EP - 811 PB - International Society for Magnetic Resonance in Medicine ER - TY - JOUR A1 - Chen, Bixia A1 - Schoemberg, Tobias A1 - Kraff, Oliver A1 - Dammann, Philipp A1 - Bitz, Andreas A1 - Schlamann, Marc A1 - Quick, Harald H. A1 - Ladd, Mark E. A1 - Sure, Ulrich A1 - Wrede, Karsten H. T1 - Cranial fixation plates in cerebral magnetic resonance imaging: a 3 and 7 Tesla in vivo image quality study JF - Magnetic Resonance Materials in Physics, Biology and Medicine N2 - Objective This study assesses and quantifies impairment of postoperative magnetic resonance imaging (MRI) at 7 Tesla (T) after implantation of titanium cranial fixation plates (CFPs) for neurosurgical bone flap fixation. Materials and methods The study group comprised five patients who were intra-individually examined with 3 and 7 T MRI preoperatively and postoperatively (within 72 h/3 months) after implantation of CFPs. Acquired sequences included T₁-weighted magnetization-prepared rapid-acquisition gradient-echo (MPRAGE), T₂-weighted turbo-spin-echo (TSE) imaging, and susceptibility-weighted imaging (SWI). Two experienced neurosurgeons and a neuroradiologist rated image quality and the presence of artifacts in consensus reading. Results Minor artifacts occurred around the CFPs in MPRAGE and T2 TSE at both field strengths, with no significant differences between 3 and 7 T. In SWI, artifacts were accentuated in the early postoperative scans at both field strengths due to intracranial air and hemorrhagic remnants. After resorption, the brain tissue directly adjacent to skull bone could still be assessed. Image quality after 3 months was equal to the preoperative examinations at 3 and 7 T. Conclusion Image quality after CFP implantation was not significantly impaired in 7 T MRI, and artifacts were comparable to those in 3 T MRI. Y1 - 2016 U6 - https://doi.org/10.1007/s10334-016-0548-1 SN - 1352-8661 VL - 29 IS - 3 SP - 389 EP - 398 PB - Springer CY - Berlin ER - TY - JOUR A1 - Schmidt, K. A1 - Forkmann, K. A1 - Sinke, C. A1 - Gratz, M. A1 - Bitz, Andreas A1 - Bingel, U. T1 - The differential effect of trigeminal vs. peripheral pain stimulation on visual processing and memory encoding is influenced by pain-related fear JF - NeuroImage N2 - Compared to peripheral pain, trigeminal pain elicits higher levels of fear, which is assumed to enhance the interruptive effects of pain on concomitant cognitive processes. In this fMRI study we examined the behavioral and neural effects of trigeminal (forehead) and peripheral (hand) pain on visual processing and memory encoding. Cerebral activity was measured in 23 healthy subjects performing a visual categorization task that was immediately followed by a surprise recognition task. During the categorization task subjects received concomitant noxious electrical stimulation on the forehead or hand. Our data show that fear ratings were significantly higher for trigeminal pain. Categorization and recognition performance did not differ between pictures that were presented with trigeminal and peripheral pain. However, object categorization in the presence of trigeminal pain was associated with stronger activity in task-relevant visual areas (lateral occipital complex, LOC), memory encoding areas (hippocampus and parahippocampus) and areas implicated in emotional processing (amygdala) compared to peripheral pain. Further, individual differences in neural activation between the trigeminal and the peripheral condition were positively related to differences in fear ratings between both conditions. Functional connectivity between amygdala and LOC was increased during trigeminal compared to peripheral painful stimulation. Fear-driven compensatory resource activation seems to be enhanced for trigeminal stimuli, presumably due to their exceptional biological relevance. Y1 - 2016 U6 - https://doi.org/10.1016/j.neuroimage.2016.03.026 SN - 1053-8119 VL - 134 SP - 386 EP - 395 PB - Elsevier CY - Amsterdam ER - TY - RPRT A1 - Sansom, M. A1 - Lawson, R.M. A1 - Tucho, R. A1 - Kendrick, C. A1 - Ogden, R. A1 - Resalati, S. A1 - Garay, R. A1 - Döring, Bernd A1 - Reger, V. A1 - Gilbert, J. A1 - Heikkinen, J. A1 - Hemmila, K. T1 - Building in active thermal mass into steel structures (BATIMASS) - EUR 28166EN N2 - The main objective of the BATIMASS project was to address how the energy balance in relatively lightweight steel buildings can be improved by building in ‘active thermal mass’ (ATM) into the building fabric. This was achieved through concept design, dynamic thermal modelling and testing of a number of potentially viable systems and concepts. A significant programme of thermal simulation modelling was undertaken utilising the thermally equivalent slab (TES) concept to model the passive thermal capacity effect of profiled, composite metal floor decks. It is apparent from the modelling results that thermal mass is a highly complex phenomenon which is highly dependent upon building type, occupancy patterns, climate and many other aspects of the building design and servicing strategy. The ATM systems developed, both conceptually and for prototype testing, focussed on water-cooled composite slabs, the Cofradal floor system and the phase change material (PCM) Energain. In addition to laboratory testing of prototypes, whole building monitoring was undertaken at the Kubik building in Spain and the RWTH test building in Germany. Advanced thermal modelling was also undertaken to estimate the likely benefits of the ATM concept designs developed and for comparison with the test results. In addition to thermal testing, structural tests were conducted on composite floor specimens incorporating embedded water pipes. This Final Report presents the results of the activities carried out under this RFCS contract RFSR CT 2012 00033. The work carried out is reported in six major sections corresponding to the technical Work Packages of the project. Only summaries of the work carried out are provided in this report; all work undertaken is fully reported in the formal project deliverables. KW - industrial research KW - iron and steel industry KW - research project KW - materials technology KW - resistance of materials KW - steel KW - metal structure KW - ingot KW - building industry KW - research report Y1 - 2016 SN - 978-92-79-63176-4 U6 - https://doi.org/10.2777/25999 SN - 1831-9424 PB - Publications Office of the European Union CY - Luxembourg ER - TY - JOUR A1 - Lagemaat, Miriam W. A1 - Breukels, Vincent A1 - Vos, Eline K. A1 - B., Adam A1 - Uden, Mark J. van A1 - Orzada, Stephan A1 - Bitz, Andreas A1 - Maas, Marnix C. A1 - Scheenen, Tom W. J. T1 - ¹H MR spectroscopic imaging of the prostate at 7T using spectral-spatial pulses JF - Magnetic Resonance in Medicine N2 - Purpose To assess the feasibility of prostate ¹H MR spectroscopic imaging (MRSI) using low-power spectral-spatial (SPSP) pulses at 7T, exploiting accurate spectral selection and spatial selectivity simultaneously. Methods A double spin-echo sequence was equipped with SPSP refocusing pulses with a spectral selectivity of 1 ppm. Three-dimensional prostate ¹H-MRSI at 7T was performed with the SPSP-MRSI sequence using an 8-channel transmit array coil and an endorectal receive coil in three patients with prostate cancer and in one healthy subject. No additional water or lipid suppression pulses were used. Results Prostate ¹H-MRSI could be obtained well within specific absorption rate (SAR) limits in a clinically feasible time (10 min). Next to the common citrate signals, the prostate spectra exhibited high spermine signals concealing creatine and sometimes also choline. Residual lipid signals were observed at the edges of the prostate because of limitations in spectral and spatial selectivity. Conclusion It is possible to perform prostate ¹H-MRSI at 7T with a SPSP-MRSI sequence while using separate transmit and receive coils. This low-SAR MRSI concept provides the opportunity to increase spatial resolution of MRSI within reasonable scan times. Y1 - 2016 U6 - https://doi.org/10.1002/mrm.25569 SN - 1522-2594 VL - 75 IS - 3 SP - 933 EP - 945 PB - International Society for Magnetic Resonance in Medicine ER - TY - CHAP A1 - Feldmann, M. A1 - Döring, Bernd A1 - Pyschny, D. T1 - Floor systems; Sustainabilty analyses and assessments of steel bridges T2 - Sustainable steel buildings : a practical guide for structures and envelopes Y1 - 2016 SN - 978-1-118-74079-8 (PDF) SN - 978-1-118-74111-5 SP - 198 EP - 223 PB - Wiley Blackwell CY - Chichester, West Sussex ER - TY - JOUR A1 - Neu, Eugen A1 - Janser, Frank A1 - Khatibi, Akbar A. A1 - Orifici, Adrian C. T1 - Automated modal parameter-based anomaly detection under varying wind excitation JF - Structural Health Monitoring N2 - Wind-induced operational variability is one of the major challenges for structural health monitoring of slender engineering structures like aircraft wings or wind turbine blades. Damage sensitive features often show an even bigger sensitivity to operational variability. In this study a composite cantilever was subjected to multiple mass configurations, velocities and angles of attack in a controlled wind tunnel environment. A small-scale impact damage was introduced to the specimen and the structural response measurements were repeated. The proposed damage detection methodology is based on automated operational modal analysis. A novel baseline preparation procedure is described that reduces the amount of user interaction to the provision of a single consistency threshold. The procedure starts with an indeterminate number of operational modal analysis identifications from a large number of datasets and returns a complete baseline matrix of natural frequencies and damping ratios that is suitable for subsequent anomaly detection. Mahalanobis distance-based anomaly detection is then applied to successfully detect the damage under varying severities of operational variability and with various degrees of knowledge about the present operational conditions. The damage detection capabilities of the proposed methodology were found to be excellent under varying velocities and angles of attack. Damage detection was less successful under joint mass and wind variability but could be significantly improved through the provision of the currently encountered operational conditions. Y1 - 2016 U6 - https://doi.org/10.1177/1475921716665803 SN - 1475-9217 VL - 15 IS - 6 SP - 1 EP - 20 PB - Sage CY - London ER - TY - CHAP A1 - Droszez, Anna A1 - Sanno, Maximilian A1 - Goldmann, Jan-Peter A1 - Albracht, Kirsten A1 - Brüggemann, Gerd-Peter A1 - Braunstein, Bjoern T1 - Differences between take-off behavior during vertical jumps and two artistic elements T2 - 34th International Conference of Biomechanics in Sport, Tsukuba, Japan, July 18-22, 2016 Y1 - 2016 SN - 1999-4168 SP - 577 EP - 580 ER - TY - GEN A1 - Gamgami, Farid A1 - Czupalla, Markus A1 - Garcia, Antonio A1 - Agnolon, David T1 - From planetary transits to spacecraft design: achieving PLATO’s pointing performance T2 - A7. Symposium on technological Requirement for future space astronomy and solar-system science missions N2 - In the last decades, several hundred exoplanets could be detected thanks to space-based observatories, namely CNES’ COROT and NASA’s Kepler. To expand this quest ESA plans to launch CHEOPS as the f irst small class mission in the cosmic visions program (S1) and PLATO as the 3rd medium class mission, so called M3 . PLATO’s primary objective is the detection of Earth like Exoplanets orbiting solar type stars in the habitable zone and characterisation of their bulk properties. This is possible by precise lightcurve measurement via 34 cameras. That said it becomes obvious that accurate pointing is key to achieve the required signal to noise ratio for positive transit detection. The paper will start with a comprehensive overview of PLATO’s mission objectives and mission architecture. Hereafter, special focus will be devoted to PLATO’s pointing requirements. Understanding the very nature of PLATO’s pointing requirements is essential to derive a design baseline to achieve the required performance. The PLATO frequency domain is of particular interest, ranging from 40 mHz to 3 Hz. Due to the very different time-scales involved, the spectral pointing requirement is decomposed into a high frequency part dominated by the attitude control system and the low frequency part dominated by the thermo-elastic properties of the spacecraft’s configuration. Both pose stringent constraints on the overall design as well as technology properties to comply with the derived requirements and thus assure a successful mission. Y1 - 2016 N1 - 67th International Astronautical Congress, 26. - 30. September 2016, Guadalajara, Mexico ER - TY - JOUR A1 - Bialonski, Stephan A1 - Caron, David A. A1 - Schloen, Julia A1 - Feudel, Ulrike A1 - Kantz, Holger A1 - Moorthi, Stefanie D. T1 - Phytoplankton dynamics in the Southern California Bight indicate a complex mixture of transport and biology JF - Journal of Plankton Research N2 - The stimulation and dominance of potentially harmful phytoplankton taxa at a given locale and time are determined by local environmental conditions as well as by transport to or from neighboring regions. The present study investigated the occurrence of common harmful algal bloom (HAB) taxa within the Southern California Bight, using cross-correlation functions to determine potential dependencies between HAB taxa and environmental factors, and potential links to algal transport via local hydrography and currents. A simulation study, in which Lagrangian particles were released, was used to assess travel times due to advection by prevailing ocean currents in the bight. Our results indicate that transport of some taxa may be an important mechanism for the expansion of their distributions into other regions, which was supported by mean travel times derived from our simulation study and other literature on ocean currents in the Southern California Bight. In other cases, however, phytoplankton dynamics were rather linked to local environmental conditions, including coastal upwelling events. Overall, our study shows that complex current patterns in the Southern California Bight may contribute significantly to the formation and expansion of HABs in addition to local environmental factors determining the spatiotemporal dynamics of phytoplankton blooms. Y1 - 2016 U6 - https://doi.org/10.1093/plankt/fbv122 SN - 1464-3774 VL - 38 IS - 4 SP - 1077 EP - 1091 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Mykoniou, Konstantin A1 - Butenweg, Christoph A1 - Holtschoppen, Britta A1 - Klinkel, Sven T1 - Seismic response analysis of adjacent liquid-storage tanks JF - Earthquake engineering and structural dynamics N2 - A refined substructure technique in the frequency domain is developed, which permits consideration of the interaction effects among adjacent containers through the supporting deformable soil medium. The tank-liquid systems are represented by means of mechanical models, whereas discrete springs and dashpots stand for the soil beneath the foundations. The proposed model is employed to assess the responses of adjacent circular, cylindrical tanks for harmonic and seismic excitations over wide range of tank proportions and soil conditions. The influence of the number, spatial arrangement of the containers and their distance on the overall system's behavior is addressed. The results indicate that the cross-interaction effects can substantially alter the impulsive components of response of each individual element in a tank farm. The degree of this impact is primarily controlled by the tank proportions and the proximity of the predominant natural frequencies of the shell-liquid-soil systems and the input seismic motion. The group effects should be not a priori disregarded, unless the tanks are founded on shallow soil deposit overlying very stiff material or bedrock. KW - liquid-structure interaction KW - seismic response KW - impulsive effects KW - liquid-storage tank KW - structure-soil-structure interaction Y1 - 2016 U6 - https://doi.org/10.1002/eqe.2726 SN - 1096-9845 (E-Journal); 0098-8847 (Print) VL - 45 IS - 11 SP - 1779 EP - 1796 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Kubalski, T. A1 - Marinković, Marko A1 - Butenweg, Christoph ED - Modena, Claudio T1 - Numerical investigation of masonry infilled R.C. frames T2 - Brick and Block Masonry. Proceedings of the 16th International Brick and Block Masonry Conference, Padova, Italy, 26-30 June 2016 Y1 - 2016 SN - 9781315374963 SP - 1219 EP - 1226 PB - CRC Press CY - Leiden ER - TY - CHAP A1 - König, Johannes Alexander A1 - Wolf, Martin R. T1 - A new definition of competence developing games - and a framework to assess them T2 - ACHI 2016 : The Ninth International Conference on Advances in Computer-Human Interactions N2 - There are different types of games that try to make use of the motivation of a gaming situation in learning contexts. This paper introduces the new terminology ‘Competence Developing Game’ (CDG) as an umbrella term for all games with this intention. Based on this new terminology, an assessment framework has been developed and validated in scope of an empirical study. Now, all different types of CDGs can be evaluated according to a defined and uniform set of assessment criteria and, thus, are comparable according to their characteristics and effectiveness. KW - Serious Games KW - Gamification KW - Business Simulations KW - Assessment Y1 - 2016 SN - 978-1-61208-468-8 N1 - Proceeding of the Ninth International Conference on Advances in Computer-Human Interactions (ACHI 2016), Venice. SP - 95 EP - 97 ER - TY - JOUR A1 - Peloni, Alessandro A1 - Ceriotti, Matteo A1 - Dachwald, Bernd T1 - Solar-sail trajectory design for a multiple near-earth-asteroid rendezvous mission JF - Journal of Guidance, Control, and Dynamics N2 - The scientific interest for near-Earth asteroids as well as the interest in potentially hazardous asteroids from the perspective of planetary defense led the space community to focus on near-Earth asteroid mission studies. A multiple near-Earth asteroid rendezvous mission with close-up observations of several objects can help to improve the characterization of these asteroids. This work explores the design of a solar-sail spacecraft for such a mission, focusing on the search of possible sequences of encounters and the trajectory optimization. This is done in two sequential steps: a sequence search by means of a simplified trajectory model and a set of heuristic rules based on astrodynamics, and a subsequent optimization phase. A shape-based approach for solar sailing has been developed and is used for the first phase. The effectiveness of the proposed approach is demonstrated through a fully optimized multiple near-Earth asteroid rendezvous mission. The results show that it is possible to visit five near-Earth asteroids within 10 years with near-term solar-sail technology. Y1 - 2016 U6 - https://doi.org/10.2514/1.G000470 SN - 0731-5090 VL - 39 IS - 12 SP - 2712 EP - 2724 PB - AIAA CY - Reston, Va. ER - TY - JOUR A1 - Bung, Daniel Bernhard A1 - Valero, Daniel T1 - Optical flow estimation in aerated flows JF - Journal of Hydraulic Research N2 - Optical flow estimation is known from Computer Vision where it is used to determine obstacle movements through a sequence of images following an assumption of brightness conservation. This paper presents the first study on application of the optical flow method to aerated stepped spillway flows. For this purpose, the flow is captured with a high-speed camera and illuminated with a synchronized LED light source. The flow velocities, obtained using a basic Horn–Schunck method for estimation of the optical flow coupled with an image pyramid multi-resolution approach for image filtering, compare well with data from intrusive conductivity probe measurements. Application of the Horn–Schunck method yields densely populated flow field data sets with velocity information for every pixel. It is found that the image pyramid approach has the most significant effect on the accuracy compared to other image processing techniques. However, the final results show some dependency on the pixel intensity distribution, with better accuracy found for grey values between 100 and 150. Y1 - 2016 U6 - https://doi.org/10.1080/00221686.2016.1173600 VL - 54 IS - 5 SP - 575 EP - 580 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Butenweg, Christoph A1 - Marinkovic, Marko A1 - Kubalski, Thomas A1 - Klinkel, Sven T1 - Masonry infilled reinforced concrete frames under horizontal loading T1 - Stahlbetonrahmen mit Ausfachungen aus Mauerwerk unter horizontalen Belastungen JF - Mauerwerk N2 - The behaviour of infilled reinforced concrete frames under horizontal load has been widely investigated, both experimentally and numerically. Since experimental tests represent large investments, numerical simulations offer an efficient approach for a more comprehensive analysis. When RC frames with masonry infill walls are subjected to horizontal loading, their behaviour is highly non-linear after a certain limit, which makes their analysis quite difficult. The non-linear behaviour results from the complex inelastic material properties of the concrete, infill wall and conditions at the wall-frame interface. In order to investigate this non-linear behaviour in detail, a finite element model using a micro modelling approach is developed, which is able to predict the complex non-linear behaviour resulting from the different materials and their interaction. Concrete and bricks are represented by a non-linear material model, while each reinforcement bar is represented as an individual part installed in the concrete part and behaving elasto-plastically. Each brick is modelled individually and connected taking into account the non-linearity of a brick mortar interface. The same approach is followed using two finite element software packages and the results are compared with the experimental results. The numerical models show a good agreement with the experiments in predicting the overall behaviour, but also very good matching for strength capacity and drift. The results emphasize the quality and the valuable contribution of the numerical models for use in parametric studies, which are needed for the derivation of design recommendations for infilled frame structures. Y1 - 2016 U6 - https://doi.org/10.1002/dama.201600703 SN - 1437-1022 VL - 20 IS - 4 SP - 305 EP - 312 PB - Ernst & Sohn CY - Berlin ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Biele, Jens A1 - Dachwald, Bernd A1 - Grimm, Christian A1 - Lange, Caroline A1 - Ulamec, Stephan T1 - Small spacecraft for small solar system body science, planetary defence and applications T2 - IEEE Aerospace Conference 2016 N2 - Following the recent successful landings and occasional re-awakenings of PHILAE, the lander carried aboard ROSETTA to comet 67P/Churyumov-Gerasimenko, and the launch of the Mobile Asteroid Surface Scout, MASCOT, aboard the HAYABUSA2 space probe to asteroid (162173) Ryugu we present an overview of the characteristics and peculiarities of small spacecraft missions to small solar system bodies (SSSB). Their main purpose is planetary science which is transitioning from a ‘pure’ science of observation of the distant to one also supporting in-situ applications relevant for life on Earth. Here we focus on missions at the interface of SSSB science and planetary defence applications. We provide a brief overview of small spacecraft SSSB missions and on this background present recent missions, projects and related studies at the German Aerospace Center, DLR, that contribute to the worldwide planetary defence community. These range from Earth orbit technology demonstrators to active science missions in interplanetary space. We provide a summary of experience from recently flown missions with DLR participation as well as a number of studies. These include PHILAE, the lander of ESA’s ROSETTA comet rendezvous mission now on the surface of comet 67P/Churyumov-Gerasimenko, and the Mobile Asteroid Surface Scout, MASCOT, now in cruise to the ~1 km diameter C-type near-Earth asteroid (162173) Ryugu aboard the Japanese sample-return probe HAYABUSA2. We introduce the differences between the conventional methods employed in the design, integration and testing of large spacecraft and the new approaches developed by small spacecraft projects. We expect that the practical experience that can be gained from projects on extremely compressed timelines or with high-intensity operation phases on a newly explored small solar system body can contribute significantly to the study, preparation and realization of future planetary defence related missions. One is AIDA (Asteroid Impact & Deflection Assessment), a joint effort of ESA, JHU/APL, NASA, OCA and DLR, combining JHU/APL’s DART (Double Asteroid Redirection Test) and ESA’s AIM (Asteroid Impact Monitor) spacecraft in a mission towards near-Earth binary asteroid system (65803) Didymos. DLR is currently applying MASCOT heritage and lessons learned to the design of MASCOT2, a lander for the AIM mission to support a bistatic low frequency radar experiment with PHILAE/ROSETTA CONSERT heritage to explore the inner structure of Didymoon which is the designated impact target for DART. Y1 - 2016 SP - 1 EP - 20 ER - TY - CHAP A1 - Lu, S. A1 - Beyer, K. A1 - Bosiljkov, V. A1 - Butenweg, Christoph A1 - D’Ayala, D. A1 - Degee, H. A1 - Gams, M. A1 - Klouda, J. A1 - Lagomarsino, S. A1 - Penna, A. A1 - Mojsilovic, N. A1 - da Porto, F. A1 - Sorrentino, L. A1 - Vintzileou, E. ED - Modena, Claudio ED - da Porto, F. ED - Valluzzi, M.R. T1 - Next generation of Eurocode 8, masonry chapter T2 - Brick and Block Masonry Proceedings of the 16th International Brick and Block Masonry Conference, Padova, Italy, 26-30 June 2016 N2 - This paper describes the procedure on the evaluation of the masonry chapter for the next generation of Eurocode 8, the European Standard for earthquake-resistant design. In CEN, TC 250/SC8, working group WG 1 has been established to support the subcommittee on the topic of masonry on both design of new structures (EN1998-1) and assessment of existing structures (EN1998-3). The aim is to elaborate suggestions for amendments which fit the current state of the art in masonry and earthquake-resistant design. Focus will be on modelling, simplified methods, linear-analysis (q-values, overstrength-values), nonlinear procedures, out-of-plane design as well as on clearer definition of limit states. Beside these, topics related to general material properties, reinforced masonry, confined masonry, mixed structures and non-structural infills will be covered too. This paper presents the preliminary work and results up to the submission date. Y1 - 2016 SN - 978-1-138-02999-6 (Print) SN - 9781315374963 (E-Book) SP - 695 EP - 700 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Bung, Daniel Bernhard A1 - Valero, Daniel ED - Dewals, Benjamin T1 - Image processing techniques for velocity estimation in highly aerated flows: bubble image velocimetry vs. optical flow T2 - Sustainable Hydraulics in the Era of Global Change : Proceedings of the 4th IAHR Europe Congress (Liege, Belgium, 27-29 July 2016) Y1 - 2016 SN - 978-1-138-02977-4 SN - 978-1-4987-8149-7 (eBook) U6 - https://doi.org/10.1201/b21902-31 SP - 151 EP - 157 PB - CRC Press ER - TY - CHAP A1 - Oertel, M. A1 - Bung, Daniel Bernhard ED - Crookston, B. ED - Tullis, B. T1 - Scouring processes downstream a crossbar block ramp BT - Session 3: Scour, erosion, sedimentation T2 - Hydraulic Structures and Water System Management. 6th IAHR International Symposium on Hydraulic Structures, Portland, OR, 27-30 June 2016 Y1 - 2016 SN - 978-1-884575-75-4 U6 - https://doi.org/10.15142/T3340628160853 SP - 549 EP - 559 ER - TY - CHAP A1 - Ferrein, Alexander A1 - Maier, Christopher A1 - Mühlbacher, Clemens A1 - Niemüller, Tim A1 - Steinbauer, Gerald A1 - Vassos, Stravros T1 - Controlling logistics robots with the action-based language YAGI T2 - Intelligent Robotics and Applications: 9th International Conference, ICIRA 2016, Tokyo, Japan, August 22-24, 2016, Proceedings, Part I Y1 - 2016 SN - 978-3-319-43505-3 (Print) SN - 978-3-319-43506-0 (Online) U6 - https://doi.org/10.1007/978-3-319-43506-0_46 N1 - Series: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) VL - 9834 SP - 525 EP - 537 PB - Springer ER - TY - CHAP A1 - Niemueller, Tim A1 - Reuter, Sebastian A1 - Ewert, Daniel A1 - Ferrein, Alexander A1 - Jeschke, Sabina A1 - Lakemeyer, Gerhard ED - Almeida, Luis T1 - The Carologistics Approach to Cope with the Increased Complexity and New Challenges of the RoboCup Logistics League 2015 T2 - RoboCup 2015: Robot World Cup XIX Y1 - 2016 SN - 978-3-319-29339-4 U6 - https://doi.org/10.1007/978-3-319-29339-4_4 N1 - Lecture Notes in Computer Science ; 9513 SP - 47 EP - 59 PB - Springer International Publishing CY - Cham ER - TY - JOUR A1 - Turaliyeva, M. A1 - Yeshibaev, A. A1 - Saparbekova, A. A1 - Akynova, L. A1 - Abildayeva, R. A1 - Sadenova, M. A1 - Sartayeva, K. A1 - Schieffer, Andre A1 - Digel, Ilya T1 - Species composition and injuriousness of stranger xylophilous fauna affecting indigenous urban dendroflora of Central Asia JF - Asian journal of microbiology, biotechnology & environmental sciences : AJMBES N2 - At the present time, one of the most serious environmental problems of Central Asia and South Kazakhstan is the ongoing large-scale deterioration of principal urban tree populations. Several major centers of massive spread of invasive plant pests have been found in urban dendroflora of this region. The degree of damage of seven most wide-spread aboriginal tree species was found to range from 21.4±1.1 to 85.4±1.8%. In particular, the integrity of the native communities of sycamore (Platanus spp.), willow (Salix spp.), poplar (Populus spp.) and elm (Ulmus spp.) is highly endangered. Our taxonomic analysis of the most dangerous tree pests of the region has revealed them as neobiontic xylophilous insects such as Cossus cossus L. (Order: Lepidoptera L.) Monochamus urussovi Fisch., Monochamus sutor L., Acanthocinus aedelis L. and Ñetonia aureate L. (Order: Coleoptera L.). We relate the origin of this threatening trend with the import of industrial wood in the mid 90’s of the last century that was associated with high degree of the constructional work in the region. Because of the absence of efficient natural predators of the pest species, the application of microbiological methods of the pest control and limitation is suggested. Y1 - 2016 SN - 0972-3005 VL - 18 IS - 2 SP - 359 EP - 366 PB - EM International ER - TY - JOUR A1 - Schiffer, Stefan A1 - Ferrein, Alexander T1 - Decision-Theoretic Planning with Fuzzy Notions in GOLOG JF - International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems N2 - In this paper we present an extension of the action language Golog that allows for using fuzzy notions in non-deterministic argument choices and the reward function in decision-theoretic planning. Often, in decision-theoretic planning, it is cumbersome to specify the set of values to pick from in the non-deterministic-choice-of-argument statement. Also, even for domain experts, it is not always easy to specify a reward function. Instead of providing a finite domain for values in the non-deterministic-choice-of-argument statement in Golog, we now allow for stating the argument domain by simply providing a formula over linguistic terms and fuzzy uents. In Golog’s forward-search DT planning algorithm, these formulas are evaluated in order to find the agent’s optimal policy. We illustrate this in the Diner Domain where the agent needs to calculate the optimal serving order. Y1 - 2016 U6 - https://doi.org/10.1142/S0218488516400134 SN - 1793-6411 VL - 24 IS - Issue Suppl. 2 SP - 123 EP - 143 PB - World Scientific CY - Singapur ER - TY - JOUR A1 - Ferrein, Alexander A1 - Steinbauer, Gerald T1 - The Interplay of Aldebaran and RoboCup JF - KI - Künstliche Intelligenz Y1 - 2016 U6 - https://doi.org/10.1007/s13218-016-0440-1 SN - 1610-1987 VL - 30 IS - 3-4 SP - 325 EP - 326 PB - Springer CY - Berlin ER - TY - CHAP A1 - Hering, T. A1 - Ulber, Roland A1 - Tippkötter, Nils T1 - Development of a screening system for antimicrobial surfaces T2 - New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany Y1 - 2016 SP - 129 PB - DECHEMA CY - Frankfurt am Main ER - TY - CHAP A1 - Capitain, C. A1 - Hering, T. A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Enzymatic polymerization of lignin model compounds and solubilized lignin in an aqueous ethanol extract T2 - New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany Y1 - 2016 SP - 151 EP - 152 PB - DECHEMA CY - Frankfurt am Main ER - TY - CHAP A1 - Niemueller, Tim A1 - Reuter, Sebastian A1 - Ferrein, Alexander A1 - Jeschke, Sabina A1 - Lakemeyer, Gerhard ED - Almeida, Luis T1 - Evaluation of the RoboCup Logistics League and Derived Criteria for Future Competitions T2 - RoboCup 2015: Robot World Cup XIX Y1 - 2016 SN - 978-3-319-29339-4 U6 - https://doi.org/10.1007/978-3-319-29339-4_3 N1 - Lecture Notes in Computer Science ; 9513 SP - 31 EP - 43 PB - Springer International Publishing CY - Cham ER - TY - JOUR A1 - Hackl, Michael A1 - Leschinger, T. A1 - Staat, Manfred A1 - Müller, Lars-Peter A1 - Wegmann, Kilian T1 - Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation JF - Knee surgery, sports traumatology, arthroscopy N2 - Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique. Y1 - 2016 U6 - https://doi.org/10.1007/s00167-016-4080-7 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 130 EP - 131 PB - Springer CY - Berlin ER - TY - THES A1 - Frotscher, Ralf T1 - Electromechanical modeling and simulation of thin cardiac tissue constructs - smoothed FEM applied to a biomechanical plate problem Y1 - 2016 N1 - Duisburg, Essen, Universität Duisburg-Essen, Diss., 2016 ER - TY - CHAP A1 - Valero, Daniel A1 - Bung, Daniel Bernhard A1 - Oertel, M. ED - Dewals, Benjamin T1 - Turbulent dispersion in bounded horizontal jets : RANS capabilities and physical modeling comparison T2 - Sustainable Hydraulics in the Era of Global Change : Proceedings of the 4th IAHR Europe Congress (Liege, Belgium, 27-29 July 2016) Y1 - 2016 SN - 978-1-138-02977-4 SN - 978-1-4987-8149-7 (eBook) U6 - https://doi.org/10.1201/b21902-13 SP - 49 EP - 55 PB - CRC Press ER - TY - CHAP A1 - Engel, M. A1 - Thieringer, J. A1 - Tippkötter, Nils T1 - Microbial electrosynthesis for sustainable biobutanol production T2 - New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany Y1 - 2016 SP - 77 EP - 78 PB - DECHEMA CY - Frankfurt am Main ER - TY - JOUR A1 - Wegmann, Kilian A1 - Hackl, Michael A1 - Staat, Manfred A1 - Mayer, Katharina A1 - Müller, Lars-Peter T1 - Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results JF - Knee surgery, sports traumatology, arthroscopy N2 - While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates. Y1 - 2016 U6 - https://doi.org/10.1007/s00167-016-4079-0 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 58 EP - 59 PB - Springer CY - Berlin ER - TY - CHAP A1 - Bäcker, Matthias A1 - Koch, C. A1 - Geiger, F. A1 - Eber, F. A1 - Gliemann, H. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - A New Class of Biosensors Based on Tobacco Mosaic Virus and Coat Proteins as Enzyme Nanocarrier T2 - Procedia Engineering Y1 - 2016 U6 - https://doi.org/10.1016/j.proeng.2016.11.228 SN - 1877-7058 N1 - Proceedings of the 30th anniversary Eurosensors Conference – Eurosensors 2016, 4-7. Sepember 2016, Budapest, Hungary VL - Vol. 168 SP - 618 EP - 621 ER - TY - JOUR A1 - Molinnus, Denise A1 - Sorich, Maren A1 - Bartz, Alexander A1 - Siegert, Petra A1 - Willenberg, Holger S. A1 - Lisdat, Fred A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate JF - Sensors and Actuators B: Chemical N2 - An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer’s solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure. Y1 - 2016 U6 - https://doi.org/10.1016/j.snb.2016.06.064 SN - 0925-4005 VL - 237 SP - 190 EP - 195 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Tran, Ngoc Trinh A1 - Tran, Thanh Ngoc A1 - Matthies, H. G. A1 - Stavroulakis, G. E. A1 - Staat, Manfred ED - Papadrakakis, M. T1 - Shakedown analysis of plate bending analysis under stochastic uncertainty by chance constrained programming T2 - ECCOMAS Congress 2016, VII European Congress on Computational Methods in Applied Sciences and Engineering. Crete Island, Greece, 5–10 June 2016 Y1 - 2016 ER - TY - CHAP A1 - Poghossian, Arshak A1 - Bronder, Thomas A1 - Scheja, S. A1 - Wu, Chunsheng A1 - Metzger-Boddien, C. A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Label-free Electrostatic Detection of DNA Amplification by PCR Using Capacitive Field-effect Devices T2 - Procedia Engineering N2 - A capacitive field-effect EIS (electrolyte-insulator-semiconductor) sensor modified with a positively charged weak polyelectrolyte of poly(allylamine hydrochloride) (PAH)/single-stranded probe DNA (ssDNA) bilayer has been used for a label-free electrostatic detection of pathogen-specific DNA amplification via polymerase chain reaction (PCR). The sensor is able to distinguish between positive and negative PCR solutions, to detect the existence of target DNA amplicons in PCR samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Y1 - 2016 U6 - https://doi.org/10.1016/j.proeng.2016.11.512 SN - 1877-7058 N1 - Proceedings of the 30th anniversary Eurosensors Conference – Eurosensors 2016, 4-7. Sepember 2016, Budapest, Hungary VL - Vol. 168 SP - 514 EP - 517 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Leicht-Scholten, Carmen A1 - Steuer-Dankert, Linda A1 - Bouffier, Anna T1 - Facing Future Challenges: Building Engineers for Tomorrow T2 - Conference proceedings : new perspectives in science education : 5th Conference edition, Florence, Italy, 17-18 March 2016 N2 - Future engineers are increasingly confronted with the so-called Megatrends which are the big social challenges society has to cope with. These Megatrends, such as “Silver Society”, “Globalization”, “Mobility” and “Female Shift” require an application-oriented perspective on Diversity especially in the engineering field. Therefore, it is necessary to enable future engineers not only to look at the technical perspectives of a problem, but also to be able to see the related questions within societies they are developing their artefacts for. The aim of teaching engineering should be to prepare engineers for these requirements and to draw attention to the diverse needs in a globalized world. Bringing together technical knowledge and social competences which go beyond a mere training of the so-called “soft skills”, is a new approach followed at RWTH Aachen University, one of the leading technical universities in Germany. RWTH Aachen University has established the bridging professorship “Gender and Diversity in Engineering” (GDI) which educates engineers with an interdisciplinary approach to expand engineering limits. In the frame of a sustainable teaching concept the research group under the leadership of Prof. Carmen Leicht-Scholten has developed an approach which imparts a supplication-specific Gender and Diversity expertise to engineers. In workshops students gain theoretical knowledge about Gender and Diversity and learn how to transfer their knowledge in their special field of study and later work. To substantiate this, the course participants have to solve case studies from real life. The cases which are developed in collaboration with non-profit organizations and enterprises from economy rise the students to challenges which are inspired by professional life. Evaluation shows the success of this approach as well as an increasing demand for such teaching formats. KW - Diversity KW - Engineering Education KW - Gender KW - Higher Education Y1 - 2016 SN - 978-886292-705-5 SP - 32 EP - 37 ER - TY - JOUR A1 - Wu, Chunsheng A1 - Poghossian, Arshak A1 - Bronder, Thomas A1 - Schöning, Michael Josef T1 - Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor JF - Sensors and Actuators B: Chemical N2 - A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules. KW - Layer-by-layer adsorption KW - Poly(allylamine hydrochloride) KW - Label-free detection KW - DNA biosensor KW - LAPS KW - Field effect Y1 - 2016 U6 - https://doi.org/10.1016/j.snb.2016.02.004 SN - 0925-4005 IS - 229 SP - 506 EP - 512 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Tran, Ngoc Trinh A1 - Tran, Thanh Ngoc A1 - Matthies, Hermann G. A1 - Stavroulakis, Georgios Eleftherios A1 - Staat, Manfred T1 - FEM Shakedown of uncertain structures by chance constrained programming T2 - PAMM Proceedings in Applied Mathematics and Mechanics Y1 - 2016 U6 - https://doi.org/10.1002/pamm.201610346 SN - 1617-7061 N1 - Special Issue: Joint 87th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM) and Deutsche Mathematiker-Vereinigung VL - 16 IS - 1 SP - 715 EP - 716 ER - TY - CHAP A1 - Staat, Manfred A1 - Duong, Minh Tuan T1 - Smoothed Finite Element Methods for Nonlinear Solid Mechanics Problems: 2D and 3D Case Studies T2 - Proceedings of the National Science and Technology Conference on Mechanical - Transportation Engineering (NSCMET 2016), 13th October 2016, Hanoi, Vietnam, Vol.2 N2 - The Smoothed Finite Element Method (SFEM) is presented as an edge-based and a facebased techniques for 2D and 3D boundary value problems, respectively. SFEMs avoid shortcomings of the standard Finite Element Method (FEM) with lower order elements such as overly stiff behavior, poor stress solution, and locking effects. Based on the idea of averaging spatially the standard strain field of the FEM over so-called smoothing domains SFEM calculates the stiffness matrix for the same number of degrees of freedom (DOFs) as those of the FEM. However, the SFEMs significantly improve accuracy and convergence even for distorted meshes and/or nearly incompressible materials. Numerical results of the SFEMs for a cardiac tissue membrane (thin plate inflation) and an artery (tension of 3D tube) show clearly their advantageous properties in improving accuracy particularly for the distorted meshes and avoiding shear locking effects. Y1 - 2016 SP - 440 EP - 445 ER - TY - CHAP A1 - Valero, Daniel A1 - Bung, Daniel Bernhard T1 - Interfacial velocity estimation in highly aerated stepped spillway flows with a single tip fibre optical probe and Artificial Neural Networks T2 - 6th IAHR International Junior Researcher and Engineer Workshop on Hydraulic Structures, May 30th to June 1st 2016. Lübeck, Germany N2 - Air-water flows can be found in different engineering applications: from nuclear engineering to huge hydraulic structures. In this paper, a single tip fibre optical probe has been used to record high frequency (over 1 MHz) phase functions at different locations of a stepped spillway. These phase functions have been related to the interfacial velocities by means of Artificial Neural Networks (ANN) and the measurements of a classical double tip conductivity probe. Special attention has been put to the input selection and the ANN dimensions. Finally, ANN have shown to be able to link the signal rising times and plateau shapes to the air-water interfacial velocity. Y1 - 2016 U6 - https://doi.org/10.15142/T3Q590 ER - TY - JOUR A1 - Goßmann, Matthias A1 - Frotscher, Ralf A1 - Linder, Peter A1 - Bayer, Robin A1 - Epple, U. A1 - Staat, Manfred A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells JF - Cellular physiology and biochemistry N2 - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential. KW - Inotropic compounds KW - Pharmacology KW - Ion channels KW - CellDrum KW - Heart tissue culture KW - Induced pluripotent stem cells KW - Cardiac myocytes Y1 - 2016 U6 - https://doi.org/10.1159/000443124 SN - 1421-9778 (Online) SN - 1015-8987 (Print) VL - 38 IS - 3 SP - 1182 EP - 1198 PB - Karger CY - Basel ER - TY - JOUR A1 - Valero, Daniel A1 - Bung, Daniel Bernhard T1 - Sensitivity of turbulent Schmidt number and turbulence model to simulations of jets in crossflow JF - Environmental Modelling and Software N2 - Environmental discharges have been traditionally designed by means of cost-intensive and time-consuming experimental studies. Some extensively validated models based on an integral approach have been often employed for water quality problems, as recommended by USEPA (i.e.: CORMIX). In this study, FLOW-3D is employed for a full 3D RANS modelling of two turbulent jet-to-crossflow cases, including free surface jet impingement. Results are compared to both physical modelling and CORMIX to better assess model performance. Turbulence measurements have been collected for a better understanding of turbulent diffusion's parameter sensitivity. Although both studied models are generally able to reproduce jet trajectory, jet separation downstream of the impingement has been reproduced only by RANS modelling. Additionally, concentrations are better reproduced by FLOW-3D when the proper turbulent Schmidt number is used. This study provides a recommendation on the selection of the turbulence model and the turbulent Schmidt number for future outfall structures design studies. Y1 - 2016 U6 - https://doi.org/10.1016/j.envsoft.2016.04.030 SN - 1364-8152 (electronic) VL - 82 SP - 218 EP - 228 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Neumann, Tobias A1 - Dülberg, Enno A1 - Schiffer, Stefan A1 - Ferrein, Alexander T1 - A rotating platform for swift acquisition of dense 3D point clouds T2 - Intelligent Robotics and Applications: 9th International Conference, ICIRA 2016, Tokyo, Japan, August 22-24, 2016, Proceedings, Part I Y1 - 2016 SN - 978-3-319-43505-3 (Print) SN - 978-3-319-43506-0 (Online) U6 - https://doi.org/10.1007/978-3-319-43506-0_22 N1 - Series: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) VL - 9834 SP - 257 EP - 268 PB - Springer ER - TY - JOUR A1 - Hackl, Michael A1 - Müller, Lars-Peter A1 - Staat, Manfred A1 - Kahmann, Stephanie Lucina A1 - Wegmann, Kilian T1 - Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques JF - Knee surgery, sports traumatology, arthroscopy N2 - Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis. Y1 - 2016 U6 - https://doi.org/10.1007/s00167-016-4080-7 SN - 0942-2056 VL - Volume 24 IS - Supplement 1 SP - 148 EP - 149 PB - Springer CY - Berlin ER - TY - JOUR A1 - Rösch, C. A1 - Kratz, F. A1 - Hering, T. A1 - Trautmann, S. A1 - Umanskaya, N. A1 - Tippkötter, Nils A1 - Müller-Renno, C.M. A1 - Ulber, Roland A1 - Hannig, M. A1 - Ziegler, C. T1 - Albumin-lysozyme interactions: cooperative adsorption on titanium and enzymatic activity JF - Colloids and Surfaces B: Biointerfaces N2 - The interplay of albumin (BSA) and lysozyme (LYZ) adsorbed simultaneously on titanium was analyzed by gel electrophoresis and BCA assay. It was found that BSA and lysozyme adsorb cooperatively. Additionally, the isoelectric point of the respective protein influences the adsorption. Also, the enzymatic activity of lysozyme and amylase (AMY) in mixtures with BSA was considered with respect to a possible influence of protein-protein interaction on enzyme activity. Indeed, an increase of lysozyme activity in the presence of BSA could be observed. In contrast, BSA does not influence the activity of amylase. Y1 - 2016 U6 - https://doi.org/10.1016/j.colsurfb.2016.09.048 VL - 149 IS - 1 SP - 115 EP - 121 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wulfhorst, Helene A1 - Duwe, Anna-Maria A1 - Merseburg, Johannes A1 - Tippkötter, Nils T1 - Compositional analysis of pretreated (beech) wood using differential scanning calorimetry and multivariate data analysis JF - Tetrahedron N2 - The composition of plant biomass varies depending on the feedstock and pre-treatment conditions and influences its processing in biorefineries. In order to ensure optimal process conditions, the quantitative proportion of the main polymeric components of the pre-treated biomass has to be determined. Current standard procedures for biomass compositional analysis are complex, the measurements are afflicted with errors and therefore often not comparable. Hence, new powerful analytical methods are urgently required to characterize biomass. In this contribution, Differential Scanning Calorimetry (DSC) was applied in combination with multivariate data analysis (MVA) to detect the cellulose content of the plant biomass pretreated by Liquid Hot Water (LHW) and Organosolv processes under various conditions. Unlike conventional techniques, the developed analytic method enables the accurate quantification of monosaccharide content of the plant biomass without any previous sample preparation. It is easy to handle and avoids errors in sample preparation. Y1 - 2016 U6 - https://doi.org/10.1016/j.tet.2016.04.029 VL - 72 IS - 46 SP - 7329 EP - 7334 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schopp, Christoph A1 - Doll, Timo A1 - Gräser, Ulrich A1 - Harzheim, Thomas A1 - Heuermann, Holger A1 - Kling, Rainer A1 - Marso, Michael T1 - Capacitively Coupled High-Pressure Lamp Using Coaxial Line Networks JF - IEEE Transactions on Microwave Theory and Techniques N2 - This paper describes the development of a capacitively coupled high-pressure lamp with input power between 20 and 43 W at 2.45 GHz, using a coaxial line network. Compared with other electrodeless lamp systems, no cavity has to be used and a reduction in the input power is achieved. Therefore, this lamp is an alternative to the halogen incandescent lamp for domestic lighting. To serve the demands of domestic lighting, the filling of the lamp is optimized over all other resulting requirements, such as high efficacy at low induced powers and fast startups. A workflow to develop RF-driven plasma applications is presented, which makes use of the hot S-parameter technique. Descriptions of the fitting process inside a circuit and FEM simulator are given. Results of the combined ignition and operation network from simulations and measurements are compared. An initial prototype is built and measurements of the lamp's lighting properties are presented along with an investigation of the efficacy optimizations using large signal amplitude modulation. With this lamp, an efficacy of 135 lmW -1 is achieved. Y1 - 2016 U6 - https://doi.org/10.1109/TMTT.2016.2600326 SN - 0018-9480 VL - 64 IS - 10 SP - 3363 EP - 3368 PB - IEEE CY - New York, NY ER - TY - GEN A1 - Möhring, S. A1 - Wulfhorst, H. A1 - Capitain, C. A1 - Roth, J. A1 - Tippkötter, Nils T1 - Fractioning of lignocellulosic biomass: Scale-down and automation of thermal pretreatment for parameter optimization T2 - Chemie Ingenieur Technik N2 - In order to efficiently convert lignocellulose, it is often necessary to conduct a pretreatment. The biomass considered in this study typically comprises of agricultural and horticultural residues, as well as beechwood. A very environmentally friendly method, namely, fungal pretreatment using white-rot fungi, leads to an enhanced enzymatic hydrolysis. In contrast to other processes presented, the energy input is extremely low. However, the fungal growth on the lignocellulosic substrates takes several weeks at least in order to be effective. Thus, the reduction of chemicals and energy for thermal processing is a target of our current research. Liquid hot water (LHW) and solvent-based pretreatment (OrganoSolv) require more complex equipment, as they depend on high temperatures (160 – 180 °C) and enhanced pressure (up to 20 bar). However, they prove to be promising processes in regard to the fractioning of lignocellulose. For optimal lignin recovery the parameters differ from those established in cellulose extraction. A novel screening system scaled down to a reaction volume of 100 mL has been developed and successfully tested for this purpose. Y1 - 2016 U6 - https://doi.org/10.1002/cite.201650288 SN - 0009-286X SN - 1522-2640 (eISSN) N1 - ProcessNet-Jahrestagung und 32. DECHEMA-Jahrestagung der Biotechnologen 2016, 12. - 15. September 2016, Eurogress Aachen VL - 88 IS - 9 SP - 1229 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Jung, Alexander A1 - Staat, Manfred A1 - Müller, Wolfram T1 - Effect of wind on flight style optimisation in ski jumping T2 - 15th International Symposium on Computer Simulation in Biomechanics ; July 9th-11th 2015, Edinburgh, UK Y1 - 2016 SP - 53 EP - 54 PB - The University of Edinburgh ; Loughborough University CY - Edinburgh ER - TY - JOUR A1 - Levers, A. A1 - Staat, Manfred A1 - Laack, Walter van T1 - Analysis of the long-term effect of the MBST® nuclear magnetic resonance therapy on gonarthrosis JF - Orthopedic Practice Y1 - 2016 VL - 47 IS - 11 SP - 521 EP - 528 ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Erni, Daniel T1 - Female pelvic floor dysfunction: progress weakening of the support system T2 - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen N2 - The structure of the female pelvic floor (PF) is an inter-related system of bony pelvis,muscles, pelvic organs, fascias, ligaments, and nerves with multiple functions. Mechanically, thepelvic organ support system are of two types: (I) supporting system of the levator ani (LA) muscle,and (II) the suspension system of the endopelvic fascia condensation [1], [2]. Significantdenervation injury to the pelvic musculature, depolimerization of the collagen fibrils of the softvaginal hammock, cervical ring and ligaments during pregnancy and vaginal delivery weakens thenormal functions of the pelvic floor. Pelvic organ prolapse, incontinence, sexual dysfunction aresome of the dysfunctions which increases progressively with age and menopause due toweakened support system according to the Integral theory [3]. An improved 3D finite elementmodel of the female pelvic floor as shown in Fig. 1 is constructed that: (I) considers the realisticsupport of the organs to the pelvic side walls, (II) employs the improvement of our previous FEmodel [4], [5] along with the patient based geometries, (III) incorporates the realistic anatomy andboundary conditions of the endopelvic (pubocervical and rectovaginal) fascia, and (IV) considersvarying stiffness of the endopelvic fascia in the craniocaudal direction [3]. Several computationsare carried out on the presented computational model with healthy and damaged supportingtissues, and comparisons are made to understand the physiopathology of the female PF disorders. Y1 - 2016 U6 - https://doi.org/10.17185/duepublico/40821 SP - 11 EP - 12 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Kahmann, Stephanie A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Müller, Lars-Peter A1 - Staat, Manfred ED - Erni, Daniel T1 - Impact of a proximal radial shortening osteotomy on the distribution of forces and the stability of the elbow T2 - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen N2 - The human arm consists of the humerus (upper arm), the medial ulna and the lateral radius (forearm). The joint between the humerus and the ulna is called humeroulnar joint and the joint between the humerus and the radius is called humeroradial joint. Lateral and medial collateral ligaments stabilize the elbow. Statistically, 2.5 out of 10,000 people suffer from radial head fractures [1]. In these fractures the cartilage is often affected. Caused by the injured cartilage, degenerative diseases like posttraumatic arthrosis may occur. The resulting pain and reduced range of motion have an impact on the patient’s quality of life. Until now, there has not been a treatment which allows typical loads in daily life activities and offers good long-term results. A new surgical approach was developed with the motivation to reduce the progress of the posttraumatic arthrosis. Here, the radius is shortened by 3 mm in the proximal part [2]. By this means, the load of the radius is intended to be reduced due to a load shift to the ulna. Since the radius is the most important stabilizer of the elbow it has to be confirmed that the stability is not affected. In the first test (Fig. 1 left), pressure distributions within the humeroulnar and humeroradial joints a native and a shortened radius were measured using resistive pressure sensors (I5076 and I5027, Tekscan, USA). The humerus was loaded axially in a tension testing machine (Z010, Zwick Roell, Germany) in 50 N steps up to 400 N. From the humerus the load is transmitted through both the radius and the ulna into the hand which is fixed on the ground. In the second test (Fig. 1 right), the joint stability was investigated using a digital image correlation system to measure the displacement of the ulna. Here, the humerus is fixed with a desired flexion angle and the unconstrained forearm lies on the ground. A rope connects the load actuator with a hook fixed in the ulna. A guide roller is used so that the rope pulls the ulna horizontally when a tensile load is applied. This creates a moment about the elbow joint with a maximum value of 7.5 Nm. Measurements were performed with varying flexion angles (0°, 30°, 60°, 90°, 120°). For both tests and each measurement, seven specimens were used. Student ́s t-test was employed to determine whether the mean values of the measurements in native specimen and operated specimens differ significantly. Y1 - 2016 U6 - https://doi.org/10.17185/duepublico/40821 SP - 7 EP - 8 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Teixeira Boura, Cristiano José A1 - Niederwestberg, Stefan A1 - McLeod, Jacqueline A1 - Herrmann, Ulf A1 - Hoffschmidt, Bernhard T1 - Development of heat exchanger for high temperature energy storage with bulk materials T2 - AIP Conference Proceedings Y1 - 2016 U6 - https://doi.org/10.1063/1.4949106 VL - 1734 IS - 1 SP - 050008-1 EP - 050008-7 ER -