TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Bauer, S. M.
A1  - Zamuraev, L. A.
T1  - Model of the transversely isotropic spherical layer for estimation of intraocular pressure changes after intravitreal injections / Bauer, S. M. ; Zamuraev, L. A. ; Kotliar, K. E.
JF  - Rossiiskii zhurnal biomekhaniki = Russian Journal of biomechanics. 10 (2006), H. 2
Y1  - 2006
SN  - 1812-5123
SP  - 41
EP  - 47
PB  - -
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Lüke, Jan Niklas
A1  - Schubert, Gerrit Alexander
A1  - Dibué-Adjei, Maxine
A1  - Kotliar, Konstantin
A1  - Hescheler, Jürgen
A1  - Clusmann, Hans
A1  - Steiger, Hans-Jakob
A1  - Hänggi, Daniel
A1  - Kamp, Marcel A.
A1  - Schneider, Toni
A1  - Neumaier, Felix
T1  - Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity
JF  - Molecular and Cellular Neuroscience
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.mcn.2019.03.003
SN  - 1044-7431
VL  - 96
IS  - 4
SP  - 35
EP  - 46
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Fuest, Matthias
A1  - Kotliar, Konstantin
A1  - Walter, Peter
A1  - Plange, Niklas
T1  - Monitoring intraocular pressure changes after intravitreal Ranibizumab injection using rebound tonometry
JF  - Ophthalmic and physiological optics
Y1  - 2014
U6  - http://dx.doi.org/10.1111/opo.12134
SN  - 1475-1313 (E-Journal); 0275-5408 (Print)
N1  - Special Issue: The Ageing Visual System
VL  - 34
IS  - 4
SP  - 438
EP  - 444
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Svetlova, O. V.
A1  - Makarov, F. N.
A1  - Zaseeva, M. V.
T1  - Morfologicheskie i funktsional'nye osobennosti resnichnogo poiaska khrustalika kak kliuchevogo ispolnitel'nogo zvena v mekhanizme akkommodatsii glaza cheloveka = Morpho-functional characteristics of lens ciliary body as a key mechanism of accommodation in
JF  - Morfologiia (Saint Petersburg, Russia). 123 (2003), H. 3
Y1  - 2003
SN  - 1026-3543
N1  - Original in Russisch, English abstract
SP  - 7
EP  - 16
PB  - -
ER  - 
TY  - JOUR
A1  - Burkhardt, Klaus
A1  - Schwarz, Sonja
A1  - Pan, Chengrui
A1  - Stelter, Felix
A1  - Kotliar, Konstantin
A1  - Eynatten, Maxilian von
A1  - Sollinger, Daniel
A1  - Lanzl, Ines
A1  - Heemann, Uwe
A1  - Baumann, Marcus
T1  - Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy
JF  - Cardiovascular Diabetology
Y1  - 2009
SN  - 1475-2840
VL  - 8
IS  - 10
SP  - 1
EP  - 8
PB  - -
ER  - 
TY  - JOUR
A1  - Maier, M. M.
A1  - Feucht, N.
A1  - Winkler von Mohrenfels, C.
A1  - Kotliar, Konstantin
A1  - Fabian, E.
A1  - Lohmann, C. P.
T1  - Nahtlose Cerclage mit Skleratunnelfixation. Sutureless Encircling Band - Clinical Experience
JF  - Klinische Monatsblätter für Augenheilkunde
Y1  - 2011
SN  - 0344-6360
VL  - 228
IS  - 5
SP  - 473
EP  - 476
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Schwarz, Sonja
A1  - Kotliar, Konstantin
A1  - Eynatten, Maximilian von
A1  - Trucksaess, Arno
A1  - Burckhardt, Klaus
A1  - Lutz, Jens
A1  - Heemann, Uwe
A1  - Lanzl, Ines
T1  - Non-diabetic chronic kidney disease influences retinal microvasculature
JF  - Kidney and Blood Pressure Research
Y1  - 2009
SN  - 1423-0143
VL  - 32
IS  - 6
SP  - 428
EP  - 433
PB  - -
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Conzen, Catharina
A1  - Weiss, Miriam
A1  - Seyfried, Katharina
A1  - Kotliar, Konstantin
A1  - Schmidt, Tobias Philip
A1  - Kuerten, David
A1  - Hescheler, Jürgen
A1  - Bruecken, Anne
A1  - Schmidt-Trucksäss, Arno
A1  - Neumaier, Felix
A1  - Wiesmann, Martin
A1  - Clusmann, Hans
A1  - Schubert, Gerrit Alexander
T1  - Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis
JF  - Frontiers in Neurology
N2  - Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.
Y1  - 2021
U6  - http://dx.doi.org/10.3389/fneur.2021.690183
SN  - 1664-2295
VL  - 12
IS  - 12
SP  - 1
EP  - 15
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Kotliar, Konstantin
A1  - Lüke, Jan Niklas
A1  - Alpdogan, Serdar
A1  - Conzen, Catharina
A1  - Lindauer, Ute
A1  - Clusmann, Hans
A1  - Hescheler, Jürgen
A1  - Vilser, Walthard
A1  - Schneider, Toni
A1  - Schubert, Gerrit Alexander
T1  - Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis
JF  - Plos one
N2  - Background
Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC.

Methods
A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed.

Results
A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001).

Conclusions
To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.
Y1  - 2018
U6  - http://dx.doi.org/10.1371/journal.pone.0204689
VL  - 13
IS  - 10
PB  - PLOS
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Dashevsky, Alexey V.
A1  - Lanzl, Ines M.
A1  - Kotliar, Konstantin
T1  - Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal
JF  - Graefe's Archive for Clinical and Experimental Ophthalmology
Y1  - 2011
SN  - 0721-832x
VL  - 249
IS  - 4
SP  - 565
EP  - 573
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Drozdova, G. A.
A1  - Shamshinova, A. M.
T1  - Ocular hemodinamics and contemporary methods of its assessment. Part II. Invasive methods of assessment of ocular blood flow
JF  - National Journal Glaucoma
Y1  - 2006
SN  - 2078-4104
VL  - Vol. 5
IS  - No. 4
SP  - 37
EP  - 49
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Drozdova, G. A.
A1  - Shamshinova, A. M.
T1  - Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 1. Assessment of blood cell velocities and flow rates in intraocular vessels and vascular beds
JF  - Journal of Glaucoma
Y1  - 2007
SN  - 2078-4104
VL  - Vol. 6
IS  - 1
SP  - 61
EP  - 68
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Drozdova, G. A.
A1  - Shamshinova, A. M.
T1  - Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 2. Static and dynamic assessment of retinal vessel reaction to stimuli
JF  - National Journal Glaucoma
Y1  - 2007
SN  - 2078-4104
VL  - Vol. 6
IS  - No. 2
SP  - 64
EP  - 71
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Drozdova, G. A.
A1  - Shamshinova, A. M.
T1  - Ocular hemodinamics and contemporary methods of its assessment.
 Part I. Ocular blood circulation and its quantitative estimation
JF  - National journal Glaucoma
Y1  - 2006
SN  - 2078-4104
VL  - Vol. 5
IS  - No. 3
SP  - 62
EP  - 73
ER  - 
TY  - JOUR
A1  - Kuchler, Timon
A1  - Günthner, Roman
A1  - Ribeiro, Andrea
A1  - Hausinger, Renate
A1  - Streese, Lukas
A1  - Wöhnl, Anna
A1  - Kesseler, Veronika
A1  - Negele, Johanna
A1  - Assali, Tarek
A1  - Carbajo-Lozoya, Javier
A1  - Lech, Maciej
A1  - Adorjan, Kristina
A1  - Stubbe, Hans Christian
A1  - Hanssen, Henner
A1  - Kotliar, Konstantin
A1  - Haller, Berhard
A1  - Heemann, Uwe
A1  - Schmaderer, Christoph
T1  - Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
N2  - Background
Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians.

Methods
In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204).

Measurements and main results
PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42% ± 1.77% vs. 4.64% ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5–190.2] vs. 189.1 [179.4–197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8–0.9] vs. 0.88 [0.8–0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = − 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters.

Conclusion
Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management.
KW  - Endothelial dysfunction
KW  - Long COVID
KW  - Post-COVID-19 syndrome
KW  - retinal microvasculature
Y1  - 2023
U6  - http://dx.doi.org/10.1007/s10456-023-09885-6
N1  - Corresponding author: Christoph Schmaderer
VL  - 26
SP  - 547
EP  - 563
PB  - Springer Nature
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Koshitz, I. N.
A1  - Svetlova, O. V.
A1  - Zaseeva, M. V.
T1  - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part I Initial theoretical presuppositions, hypotheses and facts / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotli
JF  - Glaukoma (2006)
Y1  - 2006
N1  - Original in Russisch
SP  - 35
EP  - 53
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Koshitz, I. N.
A1  - Svetlowa, O. V.
A1  - Zaseeva, M. V.
T1  - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part II Promising algorithms of practical sparing applications / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotliar
JF  - Glaukoma (2006)
Y1  - 2006
N1  - Original in Russisch
SP  - 51
EP  - 70
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Kozlova, Tatiana V.
A1  - Lanzl, Ines M.
T1  - Postoperative aqueous outflow in the human eye after glaucoma filtration surgery: biofluidmechanical considerations
JF  - Biomedizinische Technik = Biomedical Engineering
Y1  - 2009
SN  - 1862-278X
VL  - 54
IS  - 1
SP  - 14
EP  - 22
PB  - -
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Baumann, Marcus
A1  - Vilser, Walthard
A1  - Lanzl, Ines M.
T1  - Pulse wave velocity in retinal arteries of healthy volunteers
JF  - British Journal of Ophthalmology (eBJO)
Y1  - 2011
SN  - 1468-2079
VL  - 95
IS  - 11
SP  - 675
EP  - 679
PB  - BMJ Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Wiescher, A.
A1  - Kotliar, Konstantin
A1  - Neuhann, T.
A1  - Lanzl, Ines M.
T1  - Rasch progrediente Visusminderung beider Augen bei einem jungen Patienten
JF  - Der Ophthalmologe
N2  - Ein 34-jähriger männlicher Patient stellte sich zur Abklärung einer seit dem 9. Lebensjahr bestehenden und im letzten Jahr rasch progredienten Visusminderung beider Augen bei uns vor. Er beschrieb eine subjektiv zunehmende, im Spiegel für ihn selbst sichtbare, weißliche Trübung in der Pupille beidseits und eine starke Blendempfindlichkeit. Nebenbefundlich gab er rezidivierende Konjunktivitiden und morgens verklebte Lider an. Eine Allergie auf Gräserpollen und eine Unverträglichkeit auf Alkohol sowie mehrere Lebensmittel seien ebenfalls bekannt.

Zusätzlich leidet der Patient an stark ausgeprägtem atopischem Ekzem. Dieses wurde nie systemisch, sondern nur bei Bedarf mit kortisonhaltiger Salbe therapiert.
Y1  - 2010
U6  - http://dx.doi.org/10.1007/s00347-007-1586-x
SN  - 1433-0423
VL  - 105
IS  - 4
SP  - 389
EP  - 392
PB  - Springer
CY  - Berlin
ER  -