TY  - JOUR
A1  - Gaigall, Daniel
A1  - Gerstenberg, Julian
T1  - Cramér-von-Mises tests for the distribution of the excess over a confidence level
JF  - Journal of Nonparametric Statistics
N2  - The Cramér-von-Mises distance is applied to the distribution of the excess over a confidence level. Asymptotics of related statistics are investigated, and it is seen that the obtained limit distributions differ from the classical ones. For that reason, quantiles of the new limit distributions are given and new bootstrap techniques for approximation purposes are introduced and justified. The results motivate new one-sample goodness-of-fit tests for the distribution of the excess over a confidence level and a new confidence interval for the related fitting error. Simulation studies investigate size and power of the tests as well as coverage probabilities of the confidence interval in the finite sample case. A practice-oriented application of the Cramér-von-Mises tests is the determination of an appropriate confidence level for the fitting approach. The adoption of the idea to the well-known problem of threshold detection in the context of peaks over threshold modelling is sketched and illustrated by data examples.
KW  - Cramér-von-Mises test
KW  - conditional excess distribution
KW  - confidence interval
KW  - goodness-of-fit test
Y1  - 2023
U6  - https://doi.org/10.1080/10485252.2023.2173958
SN  - 1048-5252 (Print)
SN  - 1029-0311 (Online)
PB  - Taylor & Francis
ER  - 
TY  - JOUR
A1  - Liphardt, Anna-Maria
A1  - Fernandez-Gonzalo, Rodrigo
A1  - Albracht, Kirsten
A1  - Rittweger, Jörn
A1  - Vico, Laurence
T1  - Musculoskeletal research in human space flight – unmet needs for the success of crewed deep space exploration
JF  - npj Microgravity
N2  - Based on the European Space Agency (ESA) Science in Space Environment (SciSpacE) community White Paper “Human Physiology – Musculoskeletal system”, this perspective highlights unmet needs and suggests new avenues for future studies in musculoskeletal research to enable crewed exploration missions. The musculoskeletal system is essential for sustaining physical function and energy metabolism, and the maintenance of health during exploration missions, and consequently mission success, will be tightly linked to musculoskeletal function. Data collection from current space missions from pre-, during-, and post-flight periods would provide important information to understand and ultimately offset musculoskeletal alterations during long-term spaceflight. In addition, understanding the kinetics of the different components of the musculoskeletal system in parallel with a detailed description of the molecular mechanisms driving these alterations appears to be the best approach to address potential musculoskeletal problems that future exploratory-mission crew will face. These research efforts should be accompanied by technical advances in molecular and phenotypic monitoring tools to provide in-flight real-time feedback.
Y1  - 2023
U6  - https://doi.org/10.1038/s41526-023-00258-3
SN  - 2373-8065
VL  - 9
IS  - Article number: 9
SP  - 1
EP  - 9
PB  - Springer Nature
ER  - 
TY  - JOUR
A1  - Mykoniou, Konstantin
A1  - Butenweg, Christoph
A1  - Holtschoppen, Britta
A1  - Klinkel, Sven
T1  - Seismic response analysis of adjacent liquid-storage tanks
JF  - Earthquake engineering and structural dynamics
N2  - A refined substructure technique in the frequency domain is developed, which permits consideration of the interaction effects among adjacent containers through the supporting deformable soil medium. The tank-liquid systems are represented by means of mechanical models, whereas discrete springs and dashpots stand for the soil beneath the foundations. The proposed model is employed to assess the responses of adjacent circular, cylindrical tanks for harmonic and seismic excitations over wide range of tank proportions and soil conditions. The influence of the number, spatial arrangement of the containers and their distance on the overall system's behavior is addressed. The results indicate that the cross-interaction effects can substantially alter the impulsive components of response of each individual element in a tank farm. The degree of this impact is primarily controlled by the tank proportions and the proximity of the predominant natural frequencies of the shell-liquid-soil systems and the input seismic motion. The group effects should be not a priori disregarded, unless the tanks are founded on shallow soil deposit overlying very stiff material or bedrock.
KW  - liquid-structure interaction
KW  - seismic response
KW  - impulsive effects
KW  - liquid-storage tank
KW  - structure-soil-structure interaction
Y1  - 2016
U6  - https://doi.org/10.1002/eqe.2726
SN  - 1096-9845 (E-Journal); 0098-8847 (Print)
VL  - 45
IS  - 11
SP  - 1779
EP  - 1796
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Seboldt, Wolfgang
A1  - Lämmerzahl, W.
T1  - Solar Sail Propulsion: An Enabling Technology for Fundamental Physics Missions
JF  - Lasers, Clocks and Drag Free Control : Exploration of Relativistic Gravity in Space / by Hansjörg Dittus ..., eds. - ( Astrophysics and Space Science Library ; 349)
Y1  - 2008
SN  - 978-3-540-34376-9
SP  - 379
EP  - 398
PB  - Springer
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Jan Thimo, Grundmann
A1  - Bauer, Waldemar
A1  - Biele, Jens
A1  - Boden, Ralf
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Hercik, David
T1  - Capabilities of Gossamer-1 derived small spacecraft solar sails carrying Mascot-derived nanolanders for in-situ surveying of NEAs
JF  - Acta Astronautica
Y1  - 2019
U6  - https://doi.org/10.1016/j.actaastro.2018.03.019
SN  - 0094-5765
VL  - 156
IS  - 3
SP  - 330
EP  - 362
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bayer, Robin
A1  - Temiz Artmann, Aysegül
A1  - Digel, Ilya
A1  - Falkenstein, Julia
A1  - Artmann, Gerhard
A1  - Creutz, Till
A1  - Hescheler, Jürgen
T1  - Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model
JF  - Cellular Physiology and Biochemistry
N2  - Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5% and 50nM verapamil by 2,8%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.
Y1  - 2020
U6  - https://doi.org/10.33594/000000225
SN  - 1421-9778
VL  - 54
SP  - 371
EP  - 383
PB  - Cell Physiol Biochem Press
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Taddei, Francesca
A1  - Butenweg, Christoph
A1  - Klinkel, S.
T1  - Parametric investigation of the soil-structure interaction effects on the dynamic behaviour of a shallow foundation supported wind turbine considering a layered soil
JF  - Wind energy : an international journal for progress and applications in wind power conversion technology
Y1  - 2015
U6  - https://doi.org/10.1002/we.1703
SN  - 1099-1824 (E-Journal); 1095-4244 (Print)
VL  - Volume 18
IS  - Issue 3
SP  - 399
EP  - 417
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Holler, S.
A1  - Butenweg, Christoph
A1  - Noh, S.-Y.
A1  - Meskouris, Konstantin
T1  - Computational model of textile-reinforced concrete structures
JF  - Computers & structures : an international journal
Y1  - 2004
U6  - https://doi.org/10.1016/j.compstruc.2004.03.076
SN  - 1879-2243 (E-Journal); 0045-7949 (Print)
VL  - Volume 82
IS  - Issues 23-26
SP  - 1971
EP  - 1979
ER  - 
TY  - JOUR
A1  - Mistler, Michael
A1  - Butenweg, Christoph
A1  - Meskouris, Konstantin
T1  - Modelling methods of historic masonry buildings under seismic excitation
JF  - Journal of seismology
Y1  - 2006
U6  - https://doi.org/10.1007/s10950-006-9033-z
SN  - 1383-4649 (Print) ; 1573-157X (E-Journal)
VL  - Volume 10
IS  - No. 4
SP  - 497
EP  - 510
ER  - 
TY  - JOUR
A1  - Mistler, Michael
A1  - Anthoine, A.
A1  - Butenweg, Christoph
T1  - In-plane and out-of-plane homogenisation of masonry
JF  - Computers & structures
Y1  - 2007
U6  - https://doi.org/10.1016/j.compstruc.2006.08.087
SN  - 1879-2243 (E-Journal); 0045-7949 (Print)
VL  - Volume 85
IS  - Issues 17-18
SP  - 1321
EP  - 1330
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nishikawa, K.
A1  - Artmann, Gerhard
T1  - Cluster air-ion effects on bacteria and moulds
JF  - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1040
EP  - 1041
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nishikawa, K.
A1  - Cook, M.
T1  - Bactericidal effects of plasma-generated cluster ions
JF  - Medical and Biological Engineering and Computing. 43 (2005), H. 6
Y1  - 2005
SN  - 1741-0444
SP  - 800
EP  - 807
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Kern, Inna
A1  - Geenen, Eva-Maria
A1  - Akimbekov, Nuraly S.
T1  - Dental plaque removal by ultrasonic toothbrushes
JF  - dentistry journal
N2  - With the variety of toothbrushes on the market, the question arises, which toothbrush is best suited to maintain oral health? This thematic review focuses first on plaque formation mechanisms and then on the plaque removal effectiveness of ultrasonic toothbrushes and their potential in preventing oral diseases like periodontitis, gingivitis, and caries. We overviewed the physical effects that occurred during brushing and tried to address the question of whether ultrasonic toothbrushes effectively reduced the microbial burden by increasing the hydrodynamic forces. The results of published studies show that electric toothbrushes, which combine ultrasonic and sonic (or acoustic and mechanic) actions, may have the most promising effect on good oral health. Existing ultrasonic/sonic toothbrush models do not significantly differ regarding the removal of dental biofilm and the reduction of gingival inflammation compared with other electrically powered toothbrushes, whereas the manual toothbrushes show a lower effectiveness.
Y1  - 2020
U6  - https://doi.org/10.3390/dj8010028
SN  - 2304-6767
VL  - 8
IS  - 28
SP  - 1
EP  - 13
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Rossi, Leonardo
A1  - Parisi, Davide
A1  - Casari, Chiara
A1  - Montanari, Luca
A1  - Ruggieri, Gabriella
A1  - Holtschoppen, Britta
A1  - Butenweg, Christoph
T1  - Empirical Data about Direct Economic Consequences of Emilia-Romagna 2012 Earthquake on Long-Span-Beam Buildings
JF  - Earthquake Spectra
Y1  - 2019
U6  - https://doi.org/10.1193/100118EQS224DP
SN  - 1944-8201
VL  - 35
IS  - 4
SP  - 1979
EP  - 2001
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Akimbekov, Nuraly S.
A1  - Turalieva, M.
A1  - Mansurov, Z.
A1  - Temiz Artmann, Aysegül
A1  - Eshibaev, A.
A1  - Zhubanova, A.
T1  - Usage of Carbonized Plant Wastes for Purification of Aqueous Solutions
JF  - Journal of Industrial Technology and Engineering
Y1  - 2013
VL  - 2
IS  - 07
SP  - 47
EP  - 54
ER  - 
TY  - JOUR
A1  - Scheele, Sandra
A1  - Oertel, Dan
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Hellmuth, Hendrik
A1  - Maurer, Karl-Heinz
A1  - Bott, Michael
A1  - Freudl, Roland
T1  - Secretory production of an FAD cofactor-containing cytosolic enzyme (sorbitol–xylitol oxidase from Streptomyces coelicolor) using the twin-arginine translocation (Tat) pathway of Corynebacterium glutamicum
JF  - Microbial biotechnology
Y1  - 2013
SN  - 1751-7915
SP  - 202
EP  - 206
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Kayser, Peter
A1  - Artmann, Gerhard
T1  - Molecular processes in biological thermosensation
JF  - Journal of Biophysics. 2008 (2008)
Y1  - 2008
SN  - 1687-8000
SP  - 1
EP  - 9
ER  - 
TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Garvey, G. J.
A1  - Bocahut, A.
A1  - Sacquin-Mora, S.
A1  - Digel, Ilya
A1  - Schneider, G. J.
A1  - Natali, F.
A1  - Artmann, Gerhard
A1  - Zaccai, G.
T1  - Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics
JF  - Journal of the Royal Society Interface
N2  - Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 Å at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.
Y1  - 2012
U6  - https://doi.org/10.1098/rsif.2012.0364
SN  - 1742-5689
VL  - 9
IS  - 76
SP  - 2845
EP  - 2855
PB  - The Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Rossi, Leonardo
A1  - Holtschoppen, Britta
A1  - Butenweg, Christoph
T1  - Official data on the economic consequences of the 2012 Emilia-Romagna earthquake: a first analysis of database SFINGE
JF  - Bulletin of Earthquake Engineering
Y1  - 2019
U6  - https://doi.org/10.1007%2Fs10518-019-00655-8
VL  - 17
IS  - 9
SP  - 4855
EP  - 4884
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
T1  - Optimal Solar Sail Trajectories for Missions to the Outer Solar System
JF  - Journal of guidance, control, and dynamics. 28 (2005), H. 6
Y1  - 2005
SN  - 0162-3192
N1  - 2. ISSN: 0162-3192. - 3. ISSN: 0731-5090
SP  - 1187
EP  - 1193
ER  -