TY - CHAP A1 - Meskouris, Konstantin A1 - Butenweg, Christoph A1 - Hinzen, Klaus-G. A1 - Höffer, Rüdiger T1 - Stochasticity of Wind Processes and Spectral Analysis of Structural Gust Response T2 - Structural Dynamics with Applications in Earthquake and Wind Engineering N2 - Wind loads have great impact on many engineering structures. Wind storms often cause irreparable damage to the buildings which are exposed to it. Along with the earthquakes, wind represents one of the most common environmental load on structures and is relevant for limit state design. Modern wind codes indicate calculation procedures allowing engineers to deal with structural systems, which are susceptible to conduct wind-excited oscillations. In the codes approximate formulas for wind buffeting are specified which relate the dynamic problem to rather abstract parameter functions. The complete theory behind is not visible in order to simplify the applicability of the procedures. This chapter derives the underlying basic relations of the spectral method for wind buffeting and explains the main important applications of it in order to elucidate part of the theoretical background of computations after the new codes. The stochasticity of the wind processes is addressed, and the analysis of analytical as well as measurement based power spectra is outlined. Short MATLAB codes are added to the Appendix 3 which carry out the computation of a single sided auto-spectrum from a statistically stationary, discrete stochastic process. Two examples are presented. KW - Wind turbulence KW - Gust wind response KW - Spectral analysis Y1 - 2019 SN - 978-3-662-57550-5 (Online) SN - 978-3-662-57548-2 (Print) U6 - https://doi.org/10.1007/978-3-662-57550-5_3 SP - 153 EP - 196 PB - Springer CY - Berlin ER - TY - CHAP A1 - Digel, Ilya A1 - Akimbekov, Nuraly S. A1 - Kistaubayeva, Aida A1 - Zhubanova, Azhar A. ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Microbial Sampling from Dry Surfaces: Current Challenges and Solutions T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Sampling of dry surfaces for microorganisms is a main component of microbiological safety and is of critical importance in many fields including epidemiology, astrobiology as well as numerous branches of medical and food manufacturing. Aspects of biofilm formation, analysis and removal in aqueous solutions have been thoroughly discussed in literature. In contrast, microbial communities on air-exposed (dry) surfaces have received significantly less attention. Diverse surface sampling methods have been developed in order to address various surfaces and microbial groups, but they notoriously show poor repeatability, low recovery rates and suffer from lack of mutual consistency. Quantitative sampling for viable microorganisms represents a particular challenge, especially on porous and irregular surfaces. Therefore, it is essential to examine in depth the factors involved in microorganisms’ recovery efficiency and accuracy depending on the sampling technique used. Microbial colonization, retention and community composition on different dry surfaces are very complex and rely on numerous physicochemical and biological factors. This study is devoted to analyze and review the (a) physical phenomena and intermolecular forces relevant for microbiological surface sampling; (b) challenges and problems faced by existing sampling methods for viable microorganisms and (c) current directions of engineering and research aimed at improvement of quality and efficiency of microbiological surface sampling. KW - Sampling methods KW - Surface microorganisms KW - Dry surfaces KW - Microbial adhesion KW - Swabbing Y1 - 2018 SN - 978-981-10-7904-7 U6 - https://doi.org/10.1007/978-981-10-7904-7_19 SP - 421 EP - 456 PB - Springer CY - Singapore ER - TY - CHAP A1 - Staat, Manfred A1 - Heitzer, M. T1 - Basis reduction technique for limit and shakedown problems T2 - Numerical Methods for Limit and Shakedown Analysis. Deterministic and Probabilistic Approach. NIC Series Vol. 15 / Ed. by Staat, M.; Heitzer, M. Y1 - 2003 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0001-2018112115 SN - 3-00-010001-6 SP - 1 EP - 55 PB - John von Neumann Institute for Computing (NIC) CY - Jülich ER - TY - CHAP A1 - Striebing, Clemens A1 - Müller, Jörg A1 - Schraudner, Martina A1 - Gewinner, Irina Valerie A1 - Guerrero Morales, Patricia A1 - Hochfeld, Katharina A1 - Hoffman, Shekinah A1 - Kmec, Julie A. A1 - Nguyen, Huu Minh A1 - Schneider, Jannick A1 - Sheridan, Jennifer A1 - Steuer-Dankert, Linda A1 - Trimble O'Connor, Lindsey A1 - Vandevelde-Rougale, Agnès T1 - Promoting diversity and combatting discrimination in research organizations: a practitioner’s guide T2 - Diversity and discrimination in research organizations N2 - The essay is addressed to practitioners in research management and from academic leadership. It describes which measures can contribute to creating an inclusive climate for research teams and preventing and effectively dealing with discrimination. The practical recommendations consider the policy and organizational levels, as well as the individual perspective of research managers. Following a series of basic recommendations, six lessons learned are formulated, derived from the contributions to the edited collection on “Diversity and Discrimination in Research Organizations.” KW - Inclusive work climate KW - lessons learned KW - policy recommendations KW - recommendations for actions KW - bullying Y1 - 2022 SN - 978-1-80117-959-1 (Print) SN - 978-1-80117-956-0 (Online) U6 - https://doi.org/10.1108/978-1-80117-956-020221012 SP - 421 EP - 442 PB - Emerald Publishing Limited CY - Bingley ER - TY - CHAP A1 - Steuer-Dankert, Linda A1 - Leicht-Scholten, Carmen T1 - Perceiving diversity : an explorative approach in a complex research organization. T2 - Diversity and discrimination in research organizations N2 - Diversity management is seen as a decisive factor for ensuring the development of socially responsible innovations (Beacham and Shambaugh, 2011; Sonntag, 2014; López, 2015; Uebernickel et al., 2015). However, many diversity management approaches fail due to a one-sided consideration of diversity (Thomas and Ely, 2019) and a lacking linkage between the prevailing organizational culture and the perception of diversity in the respective organization. Reflecting the importance of diverse perspectives, research institutions have a special responsibility to actively deal with diversity, as they are publicly funded institutions that drive socially relevant development and educate future generations of developers, leaders and decision-makers. Nevertheless, only a few studies have so far dealt with the influence of the special framework conditions of the science system on diversity management. Focusing on the interdependency of the organizational culture and diversity management especially in a university research environment, this chapter aims in a first step to provide a theoretical perspective on the framework conditions of a complex research organization in Germany in order to understand the system-specific factors influencing diversity management. In a second step, an exploratory cluster analysis is presented, investigating the perception of diversity and possible influencing factors moderating this perception in a scientific organization. Combining both steps, the results show specific mechanisms and structures of the university research environment that have an impact on diversity management and rigidify structural barriers preventing an increase of diversity. The quantitative study also points out that the management level takes on a special role model function in the scientific system and thus has an influence on the perception of diversity. Consequently, when developing diversity management approaches in research organizations, it is necessary to consider the top-down direction of action, the special nature of organizational structures in the university research environment as well as the special role of the professorial level as role model for the scientific staff. KW - Diversity management KW - Organizational culture KW - Change management KW - Psychological concepts KW - Perception Y1 - 2022 SN - 978-1-80117-959-1 (Print) SN - 978-1-80117-956-0 (Online) U6 - https://doi.org/10.1108/978-1-80117-956-020221010 SP - 365 EP - 392 PB - Emerald Publishing Limited CY - Bingley ER - TY - CHAP A1 - Osterhage, Hannes A1 - Bialonski, Stephan A1 - Staniek, Matthäus A1 - Schindler, Kaspar A1 - Wagner, Tobias A1 - Elger, Christian E. A1 - Lehnertz, Klaus T1 - Bivariate and multivariate time series analysis techniques and their potential impact for seizure prediction T2 - Seizure Prediction in Epilepsy: From Basic Mechanisms to Clinical Applications Y1 - 2008 SN - 978-3-527-62519-2 U6 - https://doi.org/10.1002/9783527625192.ch15 SP - 189 EP - 208 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Leicht-Scholten, Carmen A1 - Steuer-Dankert, Linda T1 - Educating engineers for socially responsible solutions through design thinking T2 - Design thinking in higher education: interdisciplinary encounters N2 - There is a broad international discussion about rethinking engineering education in order to educate engineers to cope with future challenges, and particularly the sustainable development goals. In this context, there is a consensus about the need to shift from a mostly technical paradigm to a more holistic problem-based approach, which can address the social embeddedness of technology in society. Among the strategies suggested to address this social embeddedness, design thinking has been proposed as an essential complement to engineering precisely for this purpose. This chapter describes the requirements for integrating the design thinking approach in engineering education. We exemplify the requirements and challenges by presenting our approach based on our course experiences at RWTH Aachen University. The chapter first describes the development of our approach of integrating design thinking in engineering curricula, how we combine it with the Sustainable Development Goals (SDG) as well as the role of sustainability and social responsibility in engineering. Secondly, we present the course “Expanding Engineering Limits: Culture, Diversity, and Gender” at RWTH Aachen University. We describe the necessity to theoretically embed the method in social and cultural context, giving students the opportunity to reflect on cultural, national, or individual “engineering limits,” and to be able to overcome them using design thinking as a next step for collaborative project work. The paper will suggest that the successful implementation of design thinking as a method in engineering education needs to be framed and contextualized within Science and Technology Studies (STS). Y1 - 2020 SN - 978-981-15-5780-4 U6 - https://doi.org/10.1007/978-981-15-5780-4 SP - 229 EP - 246 PB - Springer CY - Singapore ER - TY - CHAP A1 - Evers, Jörg A1 - Fleischhaker, Robert A1 - Pálffy, A. A1 - Keitel, C. T1 - Light propagation : From atomic to nuclear quantum optics T2 - Modern optics and photonics: atoms and structured media Y1 - 2010 SN - 978-981431327-8 U6 - https://doi.org/10.1142/9789814313278_0001 SP - 3 EP - 15 PB - World Scientific Publishing Co. ER - TY - CHAP A1 - Wolf, C. Roland A1 - Kapelyukh, Yury A1 - Scheer, Nico A1 - Henderson, Colin J. ED - Wilson, Alan G. E. T1 - Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs N2 - The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic. Y1 - 2015 SN - 978-1-78262-778-4 U6 - https://doi.org/10.1039/9781782622376-00152 SP - 152 EP - 176 PB - RSC Publ. CY - Cambridge ER - TY - CHAP A1 - Henderson, Colin J. A1 - Wolf, C. Roland A1 - Scheer, Nico ED - Woolf, Thomas F. T1 - The use of transgenic animals to study drug metabolism T2 - Handbook of Drug Metabolism. 2nd Edition Y1 - 2009 SN - 978-1-4200-7647-9 SP - 637 EP - 658 PB - Informa Healthcare CY - New York ER - TY - CHAP A1 - Samuelsson, K. A1 - Scheer, Nico A1 - Wilson, I. A1 - Wolf, C.R. A1 - Henderson, C.J. ED - Chackalamannil, Samuel T1 - Genetically Humanized Animal Models T2 - Comprehensive Medicinal Chemistry III. 3rd Edition N2 - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development. KW - Chimeric liver-humanized mice KW - Drug distribution KW - Drug metabolism KW - Toxicology KW - Knockout mice Y1 - 2017 SN - 978-0-12-803201-5 U6 - https://doi.org/10.1016/B978-0-12-409547-2.12376-5 SP - 130 EP - 149 PB - Elsevier CY - Saint Louis ER - TY - CHAP A1 - Scheer, Nico A1 - Chu, Xiaoyan A1 - Salphati, Laurent A1 - Zamek-Gliszczynski, Maciej J. ED - Nicholls, Glynis T1 - Knockout and humanized animal models to study membrane transporters in drug development T2 - Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development Y1 - 2016 SN - 978-1-78262-379-3 U6 - https://doi.org/10.1039/9781782623793-00298 SP - 298 EP - 332 PB - Royal Society of Chemistry CY - Cambridge ER - TY - CHAP A1 - Matcha, Heike A1 - Barczik, Günter ED - Valena, Tomas ED - Avermaete, Tom ED - Vrachliotis, Georg T1 - Mass Diversity: Individualized housing via parametric typology T2 - Structuralism Reloaded? Rule-Based Design in Architecture and Urbanism Y1 - 2011 SN - 978-3-936681-47-5 SP - 354 EP - 358 PB - Edition Axel Menges CY - Fellbach ER - TY - CHAP A1 - Bozakov, Zdravko A1 - Sander, Volker T1 - OpenFlow: A Perspective for Building Versatile Networks T2 - Network-Embedded Management and Applications Y1 - 2013 SN - 978-1-4419-6769-5 U6 - https://doi.org/10.1007/978-1-4419-6769-5_11 SP - 217 EP - 245 PB - Springer CY - New York, NY ER - TY - CHAP A1 - Fateri, Miranda A1 - Gebhardt, Andreas T1 - Introduction to Additive Manufacturing T2 - 3D Printing of Optical Components N2 - Additive manufacturing (AM) works by creating objects layer by layer in a manner similar to a 2D printer with the “printed” layers stacked on top of each other. The layer-wise manufacturing nature of AM enables fabrication of freeform geometries which cannot be fabricated using conventional manufacturing methods as a one part. Depending on how each layer is created and bonded to the adjacent layers, different AM methods have been developed. In this chapter, the basic terms, common materials, and different methods of AM are described, and their potential applications are discussed. KW - Additive manufacturing KW - 3D printing KW - Digital manufacturing KW - Rapid prototyping KW - Rapid manufacturing Y1 - 2020 SN - 978-3-030-58960-8 U6 - https://doi.org/10.1007/978-3-030-58960-8_1 SP - 1 EP - 22 PB - Springer CY - Cham ER - TY - CHAP A1 - Gebhardt, Andreas A1 - Hoetter, Jan-Steffen T1 - Rapid Tooling T2 - CIRP Encyclopedia of Production Engineering Y1 - 2019 SN - 978-3-662-53120-4 U6 - https://doi.org/10.1007/978-3-662-53120-4 SP - 39 EP - 52 PB - Springer CY - Berlin, Heidelberg ER - TY - CHAP A1 - Barnat, Miriam A1 - Bosse, Elke A1 - Tight, Malcolm T1 - The Guiding Role of Theory in Mixed-Methods Research: Combining Individual and Institutional Perspectives on the Transition to Higher Education T2 - Theory and Method in Higher Education Research. Vol 3 N2 - The methodological discourse of mixed-methods research offers general procedures to combine quantitative and qualitative methods for investigating complex fields of research such as higher education. However, integrating different methods still poses considerable challenges. To move beyond general recommendations for mixed-methods research, this chapter proposes to discuss methodological issues with respect to a particular research domain. Taking current studies on the transition to higher education as an example, the authors first provide an overview of the potentials and limitations of quantitative and qualitative methods in the research domain. Second, they show the need for a conceptual framework grounded in the theory of the research object to guide the integration of different methods and findings. Finally, an example study that investigates transition with regard to the interplay of the individual student and the institutional context serves to illustrate the guiding role of theory. The framework integrates different theoretical perspectives on transition, informs the selection of the research methods, and defines the nexus of the two strands that constitute the mixed-methods design. As the interplay of individual and context is of concern for teaching and learning in general, the example presented may be fruitful for the wider field of higher education research. KW - Quantitative research KW - Mixed-Methods Research KW - Transition KW - Students KW - Higher education Y1 - 2017 SN - 978-1-78743-222-2 U6 - https://doi.org/10.1108/S2056-375220170000003001 SP - 1 EP - 19 PB - Emerald Publishing Limited ER - TY - CHAP A1 - Wilke, Thomas ED - Merlotti, Andrea T1 - Planning Process of the Di Castellamonte’s Chapel of the Holy Shroud T2 - Carlo e Amedeo di Castellamonte : 1571-1683, ingegneri e architetti per i duchi di Savoia Y1 - 2016 SN - 978-88-98229-57-4 N1 - Architettura e potere ; 4 SP - 141 EP - 152 PB - Campisano editore CY - Rom ER - TY - CHAP A1 - Drumm, Christian A1 - Lemcke, Jens A1 - Oberle, Daniel T1 - Business Process Management And Semantic Technologies T2 - The Semantic Web Y1 - 2007 SN - 978-0-387-48531-7 U6 - https://doi.org/10.1007/978-0-387-48531-7_10 SP - 207 EP - 239 PB - Springer CY - Boston, MA ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin T1 - Names of individuals T2 - European Encyclopedia of Private International Law Y1 - 2017 SN - 9781782547228 PB - Edward Elgar Publishing CY - Cheltenham, UK ER -