TY - THES A1 - Bartsch, Janosch T1 - Kleidung über Kleidung: eine Bekleidungsserie, die über die Bekleidungsindustrie informiert N2 - Kleidung ist ein Kommunikationsmedium. Im Projekt wird Bekleidung als Informationsträger genutzt, um über die verschiedenen Abschnitte im Zyklus eines Kleidungsstücks sowie die Missstände in der Bekleidungsindustrie zu informieren. Entstanden sind 6 Kleidungsstücke, jeweils eins pro Abschnitt im Zyklus, vom Baumwollanbau über Spinnereien, Produktionsfabriken, dem Einzelhandel und Gebrauch bis zur Entsorgung. Die einfach gehaltenen Kleidungsstücke besitzen Aufdrucke. Über eine Augmented-Reality-App können die Kleidungsstücke gescannt werden. In Kombination mit der digitalen Ebene werden die Aufdrucke zu Informationsgrafiken. So wird unter anderem über die grausamen Arbeitsumstände in der Produktion informiert oder darüber, dass wir unsere Kleidungsstücke durchschnittlich nur 4x anziehen. Immer geht es darum, den Betrachter dazu anzuregen, seine Konsumentscheidungen zu überdenken. KW - Kleidung KW - Mode KW - Bekleidungsindustrie KW - Erweiterte Realität KW - Bekleidungsserie Y1 - 2021 PB - FH Aachen CY - Aachen ER - TY - CHAP A1 - Kohl, Philipp A1 - Schmidts, Oliver A1 - Klöser, Lars A1 - Werth, Henri A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - STAMP 4 NLP – an agile framework for rapid quality-driven NLP applications development T2 - Quality of Information and Communications Technology. QUATIC 2021 N2 - The progress in natural language processing (NLP) research over the last years, offers novel business opportunities for companies, as automated user interaction or improved data analysis. Building sophisticated NLP applications requires dealing with modern machine learning (ML) technologies, which impedes enterprises from establishing successful NLP projects. Our experience in applied NLP research projects shows that the continuous integration of research prototypes in production-like environments with quality assurance builds trust in the software and shows convenience and usefulness regarding the business goal. We introduce STAMP 4 NLP as an iterative and incremental process model for developing NLP applications. With STAMP 4 NLP, we merge software engineering principles with best practices from data science. Instantiating our process model allows efficiently creating prototypes by utilizing templates, conventions, and implementations, enabling developers and data scientists to focus on the business goals. Due to our iterative-incremental approach, businesses can deploy an enhanced version of the prototype to their software environment after every iteration, maximizing potential business value and trust early and avoiding the cost of successful yet never deployed experiments. KW - Machine learning KW - Process model KW - Natural language processing Y1 - 2021 SN - 978-3-030-85346-4 SN - 978-3-030-85347-1 U6 - http://dx.doi.org/10.1007/978-3-030-85347-1_12 N1 - International Conference on the Quality of Information and Communications Technology, QUATIC 2021, 8-11 September, Algarve, Portugal SP - 156 EP - 166 PB - Springer CY - Cham ER - TY - CHAP A1 - Schmidts, Oliver A1 - Kraft, Bodo A1 - Winkens, Marvin A1 - Zündorf, Albert T1 - Catalog integration of heterogeneous and volatile product data T2 - DATA 2020: Data Management Technologies and Applications N2 - The integration of frequently changing, volatile product data from different manufacturers into a single catalog is a significant challenge for small and medium-sized e-commerce companies. They rely on timely integrating product data to present them aggregated in an online shop without knowing format specifications, concept understanding of manufacturers, and data quality. Furthermore, format, concepts, and data quality may change at any time. Consequently, integrating product catalogs into a single standardized catalog is often a laborious manual task. Current strategies to streamline or automate catalog integration use techniques based on machine learning, word vectorization, or semantic similarity. However, most approaches struggle with low-quality or real-world data. We propose Attribute Label Ranking (ALR) as a recommendation engine to simplify the integration process of previously unknown, proprietary tabular format into a standardized catalog for practitioners. We evaluate ALR by focusing on the impact of different neural network architectures, language features, and semantic similarity. Additionally, we consider metrics for industrial application and present the impact of ALR in production and its limitations. Y1 - 2021 SN - 978-3-030-83013-7 U6 - http://dx.doi.org/10.1007/978-3-030-83014-4_7 N1 - International Conference on Data Management Technologies and Applications, DATA 2020, 7-9 July SP - 134 EP - 153 PB - Springer CY - Cham ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Borella, Laura A1 - Ceriotti, Matteo A1 - Chand, Suditi A1 - Cordero, Federico A1 - Dachwald, Bernd A1 - Fexer, Sebastian A1 - Grimm, Christian D. A1 - Hendrikse, Jeffrey A1 - Herčík, David A1 - Herique, Alain A1 - Hillebrandt, Martin A1 - Ho, Tra-Mi A1 - Kesseler, Lars A1 - Laabs, Martin A1 - Lange, Caroline A1 - Lange, Michael A1 - Lichtenheldt, Roy A1 - McInnes, Colin R. A1 - Moore, Iain A1 - Peloni, Alessandro A1 - Plettenmeier, Dirk A1 - Quantius, Dominik A1 - Seefeldt, Patric A1 - Venditti, Flaviane c. F. A1 - Vergaaij, Merel A1 - Viavattene, Giulia A1 - Virkki, Anne K. A1 - Zander, Martin T1 - More bucks for the bang: new space solutions, impact tourism and one unique science & engineering opportunity at T-6 months and counting T2 - 7th IAA Planetary Defense Conference N2 - For now, the Planetary Defense Conference Exercise 2021's incoming fictitious(!), asteroid, 2021 PDC, seems headed for impact on October 20th, 2021, exactly 6 months after its discovery. Today (April 26th, 2021), the impact probability is 5%, in a steep rise from 1 in 2500 upon discovery six days ago. We all know how these things end. Or do we? Unless somebody kicked off another headline-grabbing media scare or wants to keep civil defense very idle very soon, chances are that it will hit (note: this is an exercise!). Taking stock, it is barely 6 months to impact, a steadily rising likelihood that it will actually happen, and a huge uncertainty of possible impact energies: First estimates range from 1.2 MtTNT to 13 GtTNT, and this is not even the worst-worst case: a 700 m diameter massive NiFe asteroid (covered by a thin veneer of Ryugu-black rubble to match size and brightness), would come in at 70 GtTNT. In down to Earth terms, this could be all between smashing fireworks over some remote area of the globe and a 7.5 km crater downtown somewhere. Considering the deliberate and sedate ways of development of interplanetary missions it seems we can only stand and stare until we know well enough where to tell people to pack up all that can be moved at all and save themselves. But then, it could just as well be a smaller bright rock. The best estimate is 120 m diameter from optical observation alone, by 13% standard albedo. NASA's upcoming DART mission to binary asteroid (65803) Didymos is designed to hit such a small target, its moonlet Dimorphos. The Deep Impact mission's impactor in 2005 successfully guided itself to the brightest spot on comet 9P/Tempel 1, a relatively small feature on the 6 km nucleus. And 'space' has changed: By the end of this decade, one satellite communication network plans to have launched over 11000 satellites at a pace of 60 per launch every other week. This level of series production is comparable in numbers to the most prolific commercial airliners. Launch vehicle production has not simply increased correspondingly – they can be reused, although in a trade for performance. Optical and radio astronomy as well as planetary radar have made great strides in the past decade, and so has the design and production capability for everyday 'high-tech' products. 60 years ago, spaceflight was invented from scratch within two years, and there are recent examples of fast-paced space projects as well as a drive towards 'responsive space'. It seems it is not quite yet time to abandon all hope. We present what could be done and what is too close to call once thinking is shoved out of the box by a clear and present danger, to show where a little more preparedness or routine would come in handy – or become decisive. And if we fail, let's stand and stare safely and well instrumented anywhere on Earth together in the greatest adventure of science. Y1 - 2021 N1 - 7th IAA Planetary Defense Conference, Vienna, Austria, 26-30 April 2021 ER - TY - RPRT A1 - Hebel, Christoph A1 - Merkens, Torsten A1 - Feyerl, Günter A1 - Kemper, Hans A1 - Busse, Daniel T1 - Elektromobilität - Verbundprojekt "COSTARTebus": Comprehensive strategy to accelerate the integration of electric-buses into existing public transport systems - Teilprojekt A : Berichtszeitraum: 01.01.2018-31.10.2020 Y1 - 2021 N1 - Förderkennzeichen BMVI 03EMEN10A Verbundnummer 01182550 PB - Fachhochschule Aachen CY - Aachen ER - TY - BOOK A1 - Kurz, Melanie A1 - Schwer, Thilo T1 - Designentscheidungen : über Begründungen im Entwurfsprozess / herausgegeben von Melanie Kurz und Thilo Schwer T3 - Schriften / Gesellschaft für Designgeschichte Y1 - 2021 SN - 978-3-89986-353-6 PB - avedition CY - Stuttgart ER - TY - CHAP A1 - Mertens, Alexander A1 - Pütz, Sebastian A1 - Brauner, Philipp A1 - Brillowski, Florian Sascha A1 - Buczak, Nadine A1 - Dammers, Hannah A1 - van Dyck, Marc A1 - Kong, Iris A1 - Königs, Peter A1 - Kortomeikel, Frauke Carole A1 - Rodemann, Niklas A1 - Schaar, Anne Kathrin A1 - Steuer-Dankert, Linda A1 - Wlecke, Shari A1 - Gries, Thomas A1 - Leicht-Scholten, Carmen A1 - Nagel, Saskia K. A1 - Piller, Frank Thomas A1 - Schuh, Günther A1 - Ziefle, Martina A1 - Nitsch, Verena T1 - Human digital shadow: Data-based modeling of users and usage in the internet of production T2 - 14th International Conference on Human System Interaction : 8-10 July 2021. Gdańsk, Poland N2 - Digital Shadows as the aggregation, linkage and abstraction of data relating to physical objects are a central vision for the future of production. However, the majority of current research takes a technocentric approach, in which the human actors in production play a minor role. Here, the authors present an alternative anthropocentric perspective that highlights the potential and main challenges of extending the concept of Digital Shadows to humans. Following future research methodology, three prospections that illustrate use cases for Human Digital Shadows across organizational and hierarchical levels are developed: human-robot collaboration for manual work, decision support and work organization, as well as human resource management. Potentials and challenges are identified using separate SWOT analyses for the three prospections and common themes are emphasized in a concluding discussion. KW - digital shadow KW - cyber physical production system KW - user & usage KW - internet of production Y1 - 2021 U6 - http://dx.doi.org/10.1109/HSI52170.2021.9538729 SP - 1 EP - 8 PB - IEEE ER - TY - CHAP A1 - Kurz, Melanie T1 - Zur Multikausalität von Designentscheidungen - eine Beispielsammlung T2 - Designentscheidungen: über Begründungen im Entwurfsprozess Y1 - 2021 SN - 978-3-89986-353-6 SP - 22 EP - 43 PB - avedition CY - Stuttgart ER - TY - JOUR A1 - Dickhoff, Jens A1 - Horikawa, Atsushi A1 - Funke, Harald T1 - Hydrogen Combustion - new DLE Combustor Addresses NOx Emissions and Flashback JF - Turbomachinery international : the global journal of energy equipment Y1 - 2021 SN - 2767-2328 SN - 0149-4147 VL - 62 IS - 4 SP - 26 EP - 27 PB - MJH Life Sciences CY - Cranbury ER - TY - JOUR A1 - Welden, Rene A1 - Jablonski, Melanie A1 - Wege, Christina A1 - Keusgen, Michael A1 - Wagner, Patrick Hermann A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Light-Addressable Actuator-Sensor Platform for Monitoring and Manipulation of pH Gradients in Microfluidics: A Case Study with the Enzyme Penicillinase JF - Biosensors N2 - The feasibility of light-addressed detection and manipulation of pH gradients inside an electrochemical microfluidic cell was studied. Local pH changes, induced by a light-addressable electrode (LAE), were detected using a light-addressable potentiometric sensor (LAPS) with different measurement modes representing an actuator-sensor system. Biosensor functionality was examined depending on locally induced pH gradients with the help of the model enzyme penicillinase, which had been immobilized in the microfluidic channel. The surface morphology of the LAE and enzyme-functionalized LAPS was studied by scanning electron microscopy. Furthermore, the penicillin sensitivity of the LAPS inside the microfluidic channel was determined with regard to the analyte’s pH influence on the enzymatic reaction rate. In a final experiment, the LAE-controlled pH inhibition of the enzyme activity was monitored by the LAPS. KW - microfluidics KW - enzyme kinetics KW - actuator-sensor system KW - light-addressable electrode KW - light-addressable potentiometric sensor Y1 - 2021 U6 - http://dx.doi.org/10.3390/bios11060171 SN - 2079-6374 N1 - This article belongs to the Special Issue "Selected Papers from the 1st International Electronic Conference on Biosensors (IECB 2020)" VL - 11 IS - 6 PB - MDPI CY - Basel ER - TY - CHAP A1 - Butenweg, Christoph A1 - Marinković, Marko A1 - Pavese, Alberto A1 - Lanese, Igor A1 - Hoffmeister, Benno A1 - Pinkawa, Marius A1 - Vulcu, Mihai-Cristian A1 - Bursi, Oreste A1 - Nardin, Chiara A1 - Paolacci, Fabrizio A1 - Quinci, Gianluca A1 - Fragiadakis, Michalis A1 - Weber, Felix A1 - Huber, Peter A1 - Renault, Philippe A1 - Gündel, Max A1 - Dyke, Shirley A1 - Ciucci, M. A1 - Marino, A. T1 - Seismic performance of multi-component systems in special risk industrial facilities T2 - 17. World Conference on Earthquake Engineering , Sendai , Japan , 17WCEE , 2021-09-27 - 2021-10-02 N2 - Past earthquakes demonstrated the high vulnerability of industrial facilities equipped with complex process technologies leading to serious damage of the process equipment and multiple and simultaneous release of hazardous substances in industrial facilities. Nevertheless, the design of industrial plants is inadequately described in recent codes and guidelines, as they do not consider the dynamic interaction between the structure and the installations and thus the effect of seismic response of the installations on the response of the structure and vice versa. The current code-based approach for the seismic design of industrial facilities is considered not enough for ensure proper safety conditions against exceptional event entailing loss of content and related consequences. Accordingly, SPIF project (Seismic Performance of Multi- Component Systems in Special Risk Industrial Facilities) was proposed within the framework of the European H2020 - SERA funding scheme (Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe). The objective of the SPIF project is the investigation of the seismic behavior of a representative industrial structure equipped with complex process technology by means of shaking table tests. The test structure is a three-story moment resisting steel frame with vertical and horizontal vessels and cabinets, arranged on the three levels and connected by pipes. The dynamic behavior of the test structure and installations is investigated with and without base isolation. Furthermore, both firmly anchored and isolated components are taken into account to compare their dynamic behavior and interactions with each other. Artificial and synthetic ground motions are applied to study the seismic response at different PGA levels. After each test, dynamic identification measurements are carried out to characterize the system condition. The contribution presents the numerical simulations to calibrate the tests on the prototype, the experimental setup of the investigated structure and installations, selected measurement data and finally describes preliminary experimental results. KW - industrial facilities KW - piping KW - installations KW - seismic loading KW - earthquakes Y1 - 2021 ER - TY - CHAP A1 - Neumann, Hannah A1 - Adam, Mario A1 - Backes, Klaus A1 - Börner, Martin A1 - Clees, Tanja A1 - Doetsch, Christian A1 - Glaeser, Susanne A1 - Herrmann, Ulf A1 - May, Johanna A1 - Rosenthal, Florian A1 - Sauer, Dirk Uwe A1 - Stadler, Ingo T1 - Development of open educational resources for renewable energy and the energy transition process T2 - ISES SWC 2021 N2 - The dissemination of knowledge about renewable energies is understood as a social task with the highest topicality. The transfer of teaching content on renewable energies into digital open educational resources offers the opportunity to significantly accelerate the implementation of the energy transition. Thus, in the here presented project six German universities create open educational resources for the energy transition. These materials are available to the public on the internet under a free license. So far there has been no publicly accessible, editable media that cover entire learning units about renewable energies extensively and in high technical quality. Thus, in this project, the content that remains up-to-date for a longer period is appropriately prepared in terms of media didactics. The materials enable lecturers to provide students with in-depth training about technologies for the energy transition. In a particular way, the created material is also suitable for making the general public knowledgeable about the energy transition with scientifically based material. KW - energy transition KW - renewable energies KW - open educational resources KW - dissemination KW - digitalization Y1 - 2021 U6 - http://dx.doi.org/10.18086/swc.2021.47.03 N1 - ISES Solar World Congress, virtual conference 25-29 October 2021 PB - International Solar Energy Society CY - Freiburg ER - TY - JOUR A1 - Fagan, Andrew J. A1 - Bitz, Andreas A1 - Björkman-Burtscher, Isabella M. A1 - Collins, Christopher M. A1 - Kimbrell, Vera A1 - Raaijmakers, Alexander J. E. T1 - 7T MR Safety JF - Journal of Magnetic Resonance Imaging (JMRI) Y1 - 2021 U6 - http://dx.doi.org/10.1002/jmri.27319 SN - 1522-2586 VL - 53 IS - 2 SP - 333 EP - 346 PB - Wiley CY - Weinheim ER - TY - THES A1 - Theisen, Paul T1 - Die ästhetische Tonalität des Jazz : Immersion durch 3D-Visualisierung und musikalische Interaktion N2 - Das Ausstellungskonzept »Free Jazz: A Collective Improvisation« widmet sich der ästhetischen Tonalität des gleichnamigen Albums von Ornette Coleman. Das besagte Album bildete den Grundstein für die Etablierung des Free Jazz – einer Musikform, die sich durch ihre schrille, hierarchiefreie Klangwelt sowie ein freies Improvisationsspiel auszeichnet und mit den gängigen Konventionen des Jazz bricht. Zu jedem der 8 Musiker, welche gemeinsam das von Coleman zusammengestellte Doppelquartett ergeben, wurden individuell abgestimmte, animierte und interaktive 3D-Gebilde konzipiert. Diese reagieren auf den Sound der jeweiligen Instrumente sowie die Position der Besuchenden und ermöglichen einen audiovisuellen, immersiven Zugang zum Album. Die Interaktion zwischen dem Publikum und den Gebilden schafft Raum für eine kollektive Improvisation auf sowohl der visuellen als auch auditiven Ebene. KW - Musik KW - Jazz KW - Improvisation KW - Immersion KW - Animation Y1 - 2021 N1 - Für diese Arbeit steht kein Volltext zur Verfügung. PB - FH Aachen CY - Aachen ER - TY - JOUR A1 - Tran, Duc Hung A1 - Ebeling, Felix T1 - Die risikoadäquate Bestimmung von Eigenkapitalkosten bei konzerninternen Routinefunktionen JF - Der Betrieb N2 - Eigenkapitalkosten sind eine wesentliche Determinante bei der Wertbestimmung von Unternehmen und Unternehmensteilen. Die Eigenkapitalkosten werden regelmäßig mittels des CAPM bestimmt. Für sog. konzerninterne Routinefunktionen mit geringem Risiko stellt diese Bestimmung mittels CAPM ein Problem dar, da börsennotierte Peergroups für eine zuverlässige Bestimmung des Beta-Faktors meist nicht identifizierbar sind. Damit ergeben sich bei Bewertungen von Routineunternehmen Unsicherheiten und Konfliktpotenzial in steuerlichen Betriebsprüfungen. Dieser Beitrag gibt einen Überblick der in der Praxis genutzten Ansätze und stellt eine theoretische Fundierung zur Bestimmung der Eigenkapitalkosten von konzerninternen Routinefunktionen vor. Dabei wird verdeutlicht, dass Eigenkapitalkosten von konzerninternen Routinefunktionen nicht denen des Gesamtkonzerns entsprechen und Praktikeransätze eine grundsätzliche Berechtigung besitzen. Y1 - 2021 SN - 0005-9935 VL - 74 IS - 29 SP - 1553 EP - 1560 ER - TY - JOUR A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Recent progress in silicon-based biologically sensitive field-effect devices JF - Current Opinion in Electrochemistry N2 - Biologically sensitive field-effect devices (BioFEDs) advantageously combine the electronic field-effect functionality with the (bio)chemical receptor’s recognition ability for (bio)chemical sensing. In this review, basic and widely applied device concepts of silicon-based BioFEDs (ion-sensitive field-effect transistor, silicon nanowire transistor, electrolyte-insulator-semiconductor capacitor, light-addressable potentiometric sensor) are presented and recent progress (from 2019 to early 2021) is discussed. One of the main advantages of BioFEDs is the label-free sensing principle enabling to detect a large variety of biomolecules and bioparticles by their intrinsic charge. The review encompasses applications of BioFEDs for the label-free electrical detection of clinically relevant protein biomarkers, deoxyribonucleic acid molecules and viruses, enzyme-substrate reactions as well as recording of the cell acidification rate (as an indicator of cellular metabolism) and the extracellular potential. Y1 - 2021 U6 - http://dx.doi.org/10.1016/j.coelec.2021.100811 SN - 2451-9103 IS - Article number: 100811 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hugenroth, Kristin A1 - Borchardt, Ralf A1 - Ritter, Philine A1 - Groß‑Hardt, Sascha A1 - Meyns, Bart A1 - Verbelen, Tom A1 - Steinseifer, Ulrich A1 - Kaufmann, Tim A. S. A1 - Engelmann, Ulrich M. T1 - Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input JF - Scientific Reports N2 - Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB. Y1 - 2021 U6 - http://dx.doi.org/10.1038/s41598-021-96397-2 SN - 2045-2322 VL - 11 IS - Art. No. 16800 SP - 1 EP - 12 PB - Springer CY - Berlin ER - TY - JOUR A1 - Neumaier, Felix A1 - Weiss, Miriam A1 - Veldeman, Michael A1 - Kotliar, Konstantin A1 - Wiesmann, Martin A1 - Schulze-Steinen, Henna A1 - Höllig, Anke A1 - Clusmann, Hans A1 - Schubert, Gerrit Alexander A1 - Albanna, Walid T1 - Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage – preliminary findings from an observational cohort study JF - Clinical Neurology and Neurosurgery N2 - Aneurysmal subarachnoid hemorrhage (aSAH) is associated with early and delayed brain injury due to several underlying and interrelated processes, which include inflammation, oxidative stress, endothelial, and neuronal apoptosis. Treatment with melatonin, a cytoprotective neurohormone with anti-inflammatory, anti-oxidant and anti-apoptotic effects, has been shown to attenuate early brain injury (EBI) and to prevent delayed cerebral vasospasm in experimental aSAH models. Less is known about the role of endogenous melatonin for aSAH outcome and how its production is altered by the pathophysiological cascades initiated during EBI. In the present observational study, we analyzed changes in melatonin levels during the first three weeks after aSAH. KW - constructive alignment KW - examination KW - long-term retention KW - multimodal KW - practical learning Y1 - 2021 U6 - http://dx.doi.org/10.1016/j.clineuro.2021.106870 SN - 0303-8467 VL - 208 IS - Article No.: 106870 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Merkens, Torsten A1 - Hebel, Christoph T1 - Sharing mobility concepts – flexible, sustainable, smart T2 - Proceedings of the 1st UNITED – Southeast Asia Automotive Interest Group (SAIG) KW - Sharing mobility KW - electro mobility KW - business models KW - mobility behaviour Y1 - 2021 SN - 978-3-902103-94-9 N1 - Proceedings of the 1st UNITED – Southeast Asia Automotive Interest Group (SAIG), International Conference, International Collaboration towards Sustainable and Green, Automotive Technology, 21-22 April 2021 Chulalongkorn University, Thailand SP - 43 EP - 44 ER - TY - JOUR A1 - Brockhaus, Moritz K. A1 - Behbahani, Mehdi A1 - Muris, Farina A1 - Jansen, Sebastian V. A1 - Schmitz- Rode, Thomas A1 - Steinseifer, Ulrich A1 - Clauser, Johanna C. T1 - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept JF - Artificial Organs N2 - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential. Y1 - 2021 U6 - http://dx.doi.org/10.1111/aor.14046 SN - 1525-1594 VL - 45 IS - 12 SP - 1513 EP - 1521 PB - Wiley CY - Weinheim ER -