TY  - JOUR
A1  - Wilson, T. L.
A1  - Blome, Hans-Joachim
T1  - The Pioneer anomaly and a rotating Gödel universe
JF  - Advances in Space Research
Y1  - 2009
SN  - 0273-1177
VL  - 44
IS  - 11
SP  - 1345
EP  - 1353
ER  - 
TY  - JOUR
A1  - Wilson, Ian D.
A1  - Wilson, Claire E.
A1  - Scheer, Nico
A1  - Dickie, A.P.
A1  - Schreiter, K.
A1  - Wilson, E. M.
A1  - Riley, R. J.
A1  - Wehr, R.
A1  - Bial, J.
T1  - The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
JF  - Biochemical pharmacology
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.bcp.2017.03.015
SN  - 1873-2968
VL  - Volume 135
SP  - 139
EP  - 150
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wilson, C. E.
A1  - Dickie, A. P.
A1  - Schreiter, K.
A1  - Wehr, R.
A1  - Wilson, E. M.
A1  - Bial, J.
A1  - Scheer, Nico
A1  - Wilson, I. D.
A1  - Riley, R. J.
T1  - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
JF  - Archives of Toxicology
N2  - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.
Y1  - 2018
U6  - http://dx.doi.org/10.1007/s00204-018-2212-1
SN  - 1432-0738
VL  - 92
IS  - 6
SP  - 1953
EP  - 1967
PB  - Springer
ER  - 
TY  - JOUR
A1  - Wilming, Anja
A1  - Begemann, Jens
A1  - Kuhne, Stefan
A1  - Regestein, Lars
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Maurer, Karl-Heinz
A1  - Büchs, Jochen
T1  - Metabolic studies of γ-polyglutamic acid production in Bacillus licheniformis by small-scale continuous cultivations
JF  - Biochemical engineering journal
Y1  - 2013
SN  - 1873-295X (E-Journal); 1369-703X (Print)
VL  - Vol. 73
SP  - 29
EP  - 37
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Wilke, Thomas
ED  - Merlotti, Andrea
T1  - Planning Process of the Di Castellamonte’s Chapel of the Holy Shroud
T2  - Carlo e Amedeo di Castellamonte : 1571-1683, ingegneri e architetti per i duchi di Savoia
Y1  - 2016
SN  - 978-88-98229-57-4
N1  - Architettura e potere ; 4
SP  - 141
EP  - 152
PB  - Campisano editore
CY  - Rom
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - Newly found plans for the chapel of the Holy Shroud
JF  - Studi Piemontesi
Y1  - 2017
SN  - 0392-7261
VL  - XLVI
IS  - 1
SP  - 75
EP  - 85
ER  - 
TY  - JOUR
A1  - Wild, Dominik
A1  - Schrezenmeier, Johannes
A1  - Czupalla, Markus
A1  - Förstner, Markus
T1  - Thermal Characterization of additive manufactured Integral Structures for Phase Change Applications
JF  - 2020 International Conference on Environmental Systems
N2  - “Infused Thermal Solutions” (ITS) introduces a method for passive thermal control to stabilize structural components thermally without active heating and cooling systems, by using phase change material (PCM) in combination with lattice – both embedded into an additive manufactured integral structure. The technology is currently under development. This paper presents the results of the thermal property measurements performed on additive manufactured ITS breadboards. Within the breadboard campaigns key characteristics of the additive manufactured specimens were derived: Mechanical parameters: specimen impermeability, minimum wall thickness, lattice structure, subsequent heat treatment. Thermal properties: thermo-optical surface properties of the additive manufactured raw material, thermal conductivity and specific heat capacity measurements. As a conclusion the paper introduces an overview of potential ITS hardware applications, expected to increase the thermal performance.
Y1  - 2020
PB  - Texas Tech University
ER  - 
TY  - JOUR
A1  - Wiesen, Sebastian
A1  - Tippkötter, Nils
A1  - Muffler, Kai
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - Adsorption of fatty acids to layered double hydroxides in aqueous systems
JF  - Adsorption
N2  - Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L−1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32−.
Y1  - 2015
VL  - 21
IS  - 6-7
SP  - 459
EP  - 466
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Wiesen, Patrick
A1  - Engemann, Heiko
A1  - Limpert, Nicolas
A1  - Kallweit, Stephan
T1  - Learning by Doing - Mobile Robotics in the FH Aachen ROS Summer School
T2  - European Robotics Forum 2018, TRROS18 Workshop
Y1  - 2018
SP  - 47
EP  - 58
ER  - 
TY  - CHAP
A1  - Wiegner, Jonas
A1  - Volker, Hanno
A1  - Mainz, Fabian
A1  - Backes, Andreas
A1  - Löken, Michael
A1  - Hüning, Felix
T1  - Wiegand-effect-powered wireless IoT sensor node
T2  - Sensoren und Messsysteme 2022
N2  - In this article we describe an Internet-of-Things sensing device with a wireless interface which is powered by the oftenoverlooked harvesting method of the Wiegand effect. The sensor can determine position, temperature or other resistively measurable quantities and can transmit the data via an ultra-low power ultra-wideband (UWB) data transmitter. With this approach we can energy-self-sufficiently acquire, process, and wirelessly transmit data in a pulsed operation. A proof-of-concept system was built up to prove the feasibility of the approach. The energy consumption of the system is analyzed and traced back in detail to the individual components, compared to the generated energy and processed to identify further optimization options. Based on the proof-of-concept, an application demonstrator was developed. Finally, we point out possible use cases.
Y1  - 2022
SN  - 978-3-8007-5835-7
SP  - 255
EP  - 260
PB  - VDE Verlag GmbH
CY  - Berlin
ER  - 
TY  - GEN
A1  - Wiegner, J.
A1  - Volker, H.
A1  - Mainz, F.
A1  - Backes, A.
A1  - Löken, M.
A1  - Hüning, Felix
T1  - Wiegand-Effect-Powered Wireless IT Sensor Node
N2  - With the growing interest in small distributed sensors for the “Internet of Things”, more attention is being paid to energy harvesting techologies. Reducing or eliminating the need for external power sources or batteries make devices more self-sufficient, more reliable, and reduces maintenance requirements. The Wiegand effect is a proven technology for harvesting small amounts of electrical power from mechanical motion.
Y1  - 2022
N1  - PSMA International Energy Harvesting Workshop ~ 5-7 April 2022, Raleigh, NC, USA
ER  - 
TY  - JOUR
A1  - Wiegand, Sandra
A1  - Voigt, Birgit
A1  - Albrecht, Dirk
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Hecker, Michael
A1  - Daniel, Rolf
A1  - Liesegang, Heiko
T1  - Fermentation stage-dependent adaptations of Bacillus licheniformis during enzyme production
JF  - Microbial Cell Factories
Y1  - 2013
U6  - http://dx.doi.org/10.1186/1475-2859-12-120
SN  - 1475-2859
VL  - 12
SP  - 120
PB  - Biomed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Wiegand, Sandra
A1  - Dietrich, Sascha
A1  - Hertel, Robert
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Volland, Sonja
A1  - Daniel, Rolf
A1  - Liesegang, Heiko
T1  - RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation
JF  - BMC genomics
Y1  - 2013
SN  - 1471-2164
VL  - Vol. 14
SP  - 667
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Whitehead, Mark
A1  - Öhlschläger, Peter
A1  - Almajhdi, Fahad N.
A1  - Alloza, Leonor
A1  - Marzábal, Pablo
A1  - Meyers, Ann E.
A1  - Hitzeroth, Inga I.
A1  - Rybicki, Edward P.
T1  - Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice
JF  - BMC cancer
Y1  - 2014
U6  - http://dx.doi.org/10.1186/1471-2407-14-367
SN  - 1471-2407
IS  - 14:367
SP  - 1
EP  - 15
PB  - BioMed Central
CY  - London
ER  - 
TY  - CHAP
A1  - Wetter, Martin
A1  - Kern, Alexander
T1  - Number of lightning strikes to tall structures - comparison of calculations and measurements using a modern lightning monitoring system
T2  - 2014 International Conference on Lightning Protection (ICLP), Shanghai, China
Y1  - 2014
SP  - 1
EP  - 7
ER  - 
TY  - JOUR
A1  - Wert, Stefan
A1  - Iken, Heiko
A1  - Schöning, Michael Josef
A1  - Matysik, Frank-Michael
T1  - Development of a temperature‐pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy
JF  - Electroanalysis
N2  - Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating.
Y1  - 2021
U6  - http://dx.doi.org/10.1002/elan.202100089
SN  - 1521-4109
IS  - Early View
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Werner, Frederik
A1  - Yoshinobu, T.
A1  - Miyamoto, K.
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Semiconductor-based sensors for imaging of chemical processes
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 5
PB  - VDE-Verl.
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Yoshinobu, Tatsuo
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Frequency behaviour of light-addressable potentiometric sensors
JF  - Physica Status Solidi (A)
N2  - Light-addressable potentiometric sensors (LAPS) are semiconductor-based potentiometric sensors, with the advantage to detect the concentration of a chemical species in a liquid solution above the sensor surface in a spatially resolved manner. The addressing is achieved by a modulated and focused light source illuminating the semiconductor and generating a concentration-depending photocurrent. This work introduces a LAPS set-up that is able to monitor the electrical impedance in addition to the photocurrent. The impedance spectra of a LAPS structure, with and without illumination, as well as the frequency behaviour of the LAPS measurement are investigated. The measurements are supported by electrical equivalent circuits to explain the impedance and the LAPS-frequency behaviour. The work investigates the influence of different parameters on the frequency behaviour of the LAPS. Furthermore, the phase shift of the photocurrent, the influence of the surface potential as well as the changes of the sensor impedance will be discussed.
Y1  - 2013
U6  - http://dx.doi.org/10.1002/pssa.201200929
SN  - 1521-396X ; 0031-8965
VL  - 210
IS  - 5
SP  - 884
EP  - 891
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up
JF  - Sensors and Actuators B: Chemical
N2  - Light-addressable potentiometric sensors (LAPS) are field-effect-based sensors. A modulated light source is used to define the particular measurement spot to perform spatially resolved measurements of chemical species and to generate chemical images. In this work, an organic-LED (OLED) display has been chosen as a light source. This allows high measurement resolution and miniaturisation of the system. A new developed driving method for the OLED display optimised for LAPS-based measurements is demonstrated. The new method enables to define modulation frequencies between 1 kHz and 16 kHz and hence, reduces the measurement time of a chemical image by a factor of 40 compared to the traditional addressing of an OLED display.
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.snb.2011.12.102
SN  - 0925-4005
N1  - Part of special issue "Selected Papers presented at Eurosensors XXV"
VL  - 175
SP  - 118
EP  - 122
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up
JF  - Procedia Engineering. 25 (2011)
Y1  - 2011
SN  - 1877-7058
N1  - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP  - 346
EP  - 349
PB  - Elsevier
CY  - Amsterdam
ER  -