TY - JOUR A1 - Scheer, Nico A1 - Wilson, Ian D. T1 - A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity JF - Drug Discovery Today N2 - Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug–drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.drudis.2015.09.002 SN - 1359-6446 VL - 21 IS - 2 SP - 250 EP - 263 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Gerhardt, Hans Joachim A1 - Cooper, K.-R. A1 - Whitbread, R. A1 - Gary, K.-P. (u.a.) T1 - A comparison of aerodynamic drag measurements on model trucks in closed-jet and open-jet wind tunnels Y1 - 1985 N1 - Konferenz-Einzelbericht : 6th Colloquium on Industrial Aerodynamics, Road Vehicle Aerodynamics, Fachhochschule Aachen, 19.-21.6.1985 SP - 261 EP - 274 ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Staat, Manfred T1 - A computational study of organ relocation after laparoscopic pectopexy to repair posthysterectomy vaginal vault prolapse JF - Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization Y1 - 2019 U6 - http://dx.doi.org/10.1080/21681163.2019.1670095 SN - 2168-1171 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Digel, Ilya A1 - Dachwald, Bernd A1 - Artmann, Gerhard A1 - Linder, Peter A1 - Funke, O. T1 - A concept of a probe for particle analysis and life detection in icy environments Y1 - 2009 N1 - International workshop “Europa lander: science goals and experiments”, Space Research Institute (IKI), Moscow, Russia 9-13 February 2009 SP - 1 EP - 24 ER - TY - JOUR A1 - Köhler, Klemens T1 - A conflict theory perspective of IT attacks – consequences for IT security education N2 - Cyberspace is "the environment formed by physical and non-physical components to store, modify, and exchange data using computer networks" (NATO CCDCOE). Beyond that, it is an environment where people interact. IT attacks are hostile, non-cooperative interactions that can be described with conflict theory. Applying conflict theory to IT security leads to different objectives for end-user education, requiring different formats like agency-based competence developing games. Y1 - 2020 IS - Preprint ER - TY - JOUR A1 - Ditzhaus, Marc A1 - Gaigall, Daniel T1 - A consistent goodness-of-fit test for huge dimensional and functional data JF - Journal of Nonparametric Statistics N2 - A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cramér-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals. KW - Cramér-von-Mises statistic KW - separable Hilbert space KW - huge dimensional data KW - functional data Y1 - 2018 U6 - http://dx.doi.org/10.1080/10485252.2018.1486402 SN - 1029-0311 VL - 30 IS - 4 SP - 834 EP - 859 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Breitbach, Gerd A1 - Schubert, F. T1 - A contribution to stress prediction in coatings for gas turbine blades JF - Archive of applied mechanics. 73 (2004), H. 9-10 Y1 - 2004 SN - 0939-1533 N1 - 2. ISSN (Druck-Ausg.): 1432-0681 SP - 682 EP - 689 ER - TY - JOUR A1 - Gerling, Ulrich A1 - Pool, M. J. A1 - Predel, Bruno T1 - A contribution to the associate model for binary liquid alloys = Ein Beitrag zum Assoziat-Modell für binäre flüssige Legierungen JF - Zeitschrift für Metallkunde : international journal of materials research and advanced techniques. Bd. 74, H. 9 Y1 - 1983 SN - 0044-3093 ; 0179-4841 SP - 616 EP - 619 ER - TY - JOUR A1 - Haeger, Gerrit A1 - Bongaerts, Johannes A1 - Siegert, Petra T1 - A convenient ninhydrin assay in 96-well format for amino acid-releasing enzymes using an air-stable reagent JF - Analytical Biochemistry N2 - An improved and convenient ninhydrin assay for aminoacylase activity measurements was developed using the commercial EZ Nin™ reagent. Alternative reagents from literature were also evaluated and compared. The addition of DMSO to the reagent enhanced the solubility of Ruhemann's purple (RP). Furthermore, we found that the use of a basic, aqueous buffer enhances stability of RP. An acidic protocol for the quantification of lysine was developed by addition of glacial acetic acid. The assay allows for parallel processing in a 96-well format with measurements microtiter plates. Y1 - 2022 U6 - http://dx.doi.org/10.1016/j.ab.2022.114819 SN - 1096-0309 IS - 624 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Pietsch, Wolfram A1 - Kurbel, Karl T1 - A Cooperative Work Environment for Evolutionary Software Development / Kurbel, K., Pietsch, W. JF - Multi-user interfaces and applications : proceedings of the IFIP WG 8.4 Conference on Multi-User Interfaces and Applications, Heraklion, Crete, Greece, 24 - 26 September, 1990 / ed. by Simon Gibbs ... Y1 - 1990 SN - 0-444-88760-1 N1 - Conference on Multi-User Interfaces and Applications <1990, Hērakleion> SP - 115 EP - 127 PB - North-Holland Publ. CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Bohrn, Ulrich A1 - Mucha, Andreas A1 - Werner, Frederik A1 - Trattner, Barbara A1 - Bäcker, Matthias A1 - Krumbe, Christoph A1 - Schienle, Meinrad A1 - Stütz, Evamaria A1 - Schmitt-Landsiedel, Doris A1 - Fleischer, Maximilian A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - A critical comparison of cell-based sensor systems for the detection of Cr (VI) in aquatic environment JF - Sensors and actuators. B: Chemical Y1 - 2013 SN - 1873-3077 (E-Journal); 0925-4005 (Print) VL - Vol. 182 SP - 58 EP - 65 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Harder, Jörn T1 - A crystallographic model for the study of local deformation processes in polycrystals JF - International journal of plasticity. 15 (1999), H. 6 Y1 - 1999 SN - 0749-6419 N1 - Online: http://opus.tu-bs.de/opus/volltexte/1999/10/pdf/10_1.pdf SP - 605 EP - 624 ER - TY - JOUR A1 - Sander, Volker A1 - Foster, Ian A1 - Roy, Alain A1 - Winkler, Linda T1 - A differentiated services implementation for high-performance TCP flows JF - Computer Networks. 34 (2000), H. 6 Y1 - 2000 SN - 1389-1286 SP - 915 EP - 929 ER - TY - JOUR A1 - Öhlschläger, Peter A1 - Osen, Wolfram A1 - Peiler, Tanja A1 - Caldeira, Sandra T1 - A DNA vaccine based on a shuffled E7 oncogene of the human papillomavirus type 16 (HPV 16) induces E7-specific cytotoxic T cells but lacks transforming activity / Osen, Wolfram ; Peiler, Tanja ; Öhlschläger, Peter ; Caldeira, Sandra ; Faath, Stefan ; Mich JF - Vaccine. 19 (2001), H. 20 Y1 - 2001 SN - 0264-410X SP - 4276 EP - 4286 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Krause, R. A1 - Block, K. A1 - Musameh, M. A1 - Mulchandani, A. A1 - Wang, J. T1 - A dual amperometric / potentiometric FIA-based biosensor for the distinctive detection of organophosphorus pesticides JF - Book of abstracts / ed. by J. Saneistr. Y1 - 2002 SN - 80-01-02576-4 N1 - Eurosensors ; (16, 2002, Praha) SP - 76 EP - 79 PB - Czech Technical University, Faculty of Electrical Engineering, Department of Measurement CY - Prague ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Krause, R. A1 - Block, K. A1 - Musahmeh, M. A1 - Mulchandani, A. A1 - Wang, J. T1 - A dual amperometric/potentiometric FIA-based biosensor for the distinctive detection of organophosphorus pesticides JF - Sensors and Actuators B. 95 (2003), H. 1-3 Y1 - 2003 SN - 0925-4005 SP - 291 EP - 296 ER - TY - JOUR A1 - Bernecker, Andreas T1 - A European Private Company: Is Europe’s single legal form for SMEs close to approval? JF - Research Briefing N2 - This Research Briefing, issued in July 2010, concluded that: - Small and medium-sized enterprises (SMEs) in Europe have long called for a matching legal form valid across the EU (similar to that of the European company (SE) for large firms) - The main benefits would be the availability of uniform Europe-wide company structures, significant cost reductions for businesses and further integration of the internal market - Given the differing national views regarding the concrete features of the new legal form there is currently no sign of an agreement being reached at the European level in the short term; however, it is possible that progress will be made in negotiations during the year - The key issues being discussed in depth are company formation, transnationality and employee participation rights in the new European private company (SPE). Y1 - 2010 SN - 2193-5955 PB - Deutsche Bank Research CY - Frankfurt a. M. ER - TY - JOUR A1 - Heuermann, Holger A1 - Schiek, Burkhard T1 - A Fast and Robust Procedure for the Determination of the Scattering Parameters for Network Analyzer Calibration Y1 - 1992 N1 - Precision electromagnetic measurements : conference Paris, 9-12 June 1992 = Conférence sur les Mesures Electromagnétiques de Précision. SP - 373 EP - 374 CY - Paris ER - TY - JOUR A1 - Schmitz, Günter A1 - Roetert, J. A1 - Pischinger, M. T1 - A Fast Intelligent VMEbus System for Combustion Analysis in Engines JF - 19th [nineteenth] International Symposium on Automotive Technology & [and] Automation : with particular reference to cell control and quality management systems for the manufacturing industries; Monte Carlo, 24. - 28. October 1988. Y1 - 1988 SN - 0947719229 SP - 381 EP - 391 PB - Automotive Automation Ltd CY - Croydon ER - TY - JOUR A1 - Weber, Tobias A1 - Arent, Jan-Christoph A1 - Münch, Lukas A1 - Duhovic, Miro A1 - Balvers, Johannes M. T1 - A fast method for the generation of boundary conditions for thermal autoclave simulation JF - Composites Part A N2 - Manufacturing process simulation enables the evaluation and improvement of autoclave mold concepts early in the design phase. To achieve a high part quality at low cycle times, the thermal behavior of the autoclave mold can be investigated by means of simulations. Most challenging for such a simulation is the generation of necessary boundary conditions. Heat-up and temperature distribution in an autoclave mold are governed by flow phenomena, tooling material and shape, position within the autoclave, and the chosen autoclave cycle. This paper identifies and summarizes the most important factors influencing mold heat-up and how they can be introduced into a thermal simulation. Thermal measurements are used to quantify the impact of the various parameters. Finally, the gained knowledge is applied to develop a semi-empirical approach for boundary condition estimation that enables a simple and fast thermal simulation of the autoclave curing process with reasonably high accuracy for tooling optimization. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.compositesa.2016.05.036 SN - 1359-835X VL - 88 SP - 216 EP - 225 PB - Elsevier CY - Amsterdam ER -