TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Cherstvy, Andrey G.
A1  - Pedraza, Angela M.
A1  - Ingebrandt, Sven
A1  - Schöning, Michael Josef
T1  - Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling
JF  - Physica Status Solidi (a)
N2  - Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100710
SN  - 1862-6319
VL  - 209
SP  - 925
EP  - 934
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Reisgen, Uwe
A1  - Olschok, Simon
A1  - Jakobs, Stefan
A1  - Schleser, Markus
A1  - Mokrov, Oleg
A1  - Rossiter, Eduardo
T1  - Laser beam submerged arc hybrid welding
JF  - Physics procedia
N2  - The laser beam-submerged arc hybrid welding method originates from the knowledge that, with increasing penetration depth, the laser beam process has a tendency to pore formation in the lower weld regions. The coupling with the energy-efficient submerged-arc process improves degassing and reduces the tendency to pore formation. The high deposition rate of the SA process in combination with the laser beam process offers, providing the appropriate choice of weld preparation, the possibility of welding plates with a thickness larger than 20° mm in a single pass, and also of welding thicker plates with the double-sided single pass technique.
Y1  - 2012
U6  - https://doi.org/10.1016/j.phpro.2012.10.016
SN  - 1875-3892
N1  - Part of special issue "Laser assisted net shape engineering 7 (LANE 2012)"
VL  - 39
SP  - 75
EP  - 83
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Shigiahara, N.
A1  - Miyamoto, K.
A1  - Suzurikawa, J.
A1  - Finger, F.
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
T1  - Light-addressable Potentiometric Sensors and Light–addressable Electrodes as a Combined Sensor-and-manipulator Microsystem with High Flexibility
JF  - Procedia Engineering
N2  - This work describes the novel combination of the light-addressable electrode (LAE) and the light-addressable potentiometric sensor (LAPS) into a microsystem set-up. Both the LAE as well as the LAPS shares the principle of addressing the active spot by means of a light beam. This enables both systems to manipulate resp. to detect an analyte with a high spatial resolution. Hence, combining both principles into a single set-up enables the active stimulation e.g., by means of electrolysis and a simultaneous observation e.g., the response of an entrapped biological cell by detection of extracellular pH changes. The work will describe the principles of both technologies and the necessary steps to integrate them into a single set-up. Furthermore, examples of application and operation of such systems will be presented.
Y1  - 2012
U6  - https://doi.org/10.1016/j.proeng.2012.09.290
SN  - 1877-7058
N1  - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012"
IS  - 47
SP  - 890
EP  - 893
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Vu, Duc Khoi
T1  - Limit analysis of flaws in pressurized pipes and cylindrical vessels Part II: Circumferential defects
JF  - Engineering Fracture Mechanics ; 97(2013), H. 1
N2  - Upper and lower bound theorems of limit analyses have been presented in part I of the paper. Part II starts with the finite element discretization of these theorems and demonstrates how both can be combined in a primal–dual optimization problem. This recently proposed numerical method is used to guide the development of a new class of closed-form limit loads for circumferential defects, which show that only large defects contribute to plastic collapse with a rapid loss of strength with increasing crack sizes. The formulae are compared with primal–dual FEM limit analyses and with burst tests. Even closer predictions are obtained with iterative limit load solutions for the von Mises yield function and for the Tresca yield function. Pressure loading of the faces of interior cracks in thick pipes reduces the collapse load of circumferential defects more than for axial flaws. Axial defects have been treated in part I of the paper.
Y1  - 2012
U6  - https://doi.org/10.1016/j.engfracmech.2012.05.017
SN  - 0013-7944
VL  - 97
SP  - 314
EP  - 333
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Limit and shakedown analysis under uncertainty
JF  - Tap chi Khoa hoc & ung dung - Dai hoc Ton Duc Thang
Y1  - 2012
N1  - = Journal of Applied Sciences - Ton Duc Thang University
VL  - 19
SP  - 45
EP  - 47
ER  - 
TY  - JOUR
A1  - Reisgen, Uwe
A1  - Schleser, Markus
A1  - Abdurakhmanov, Aydemir
A1  - Gumenyuk, Andrey
T1  - Measuring of plasma properties induced by non-vacuum electron beam welding
JF  - Physics of plasma
N2  - Electron beam plasma measurement was realised by means of DIABEAM system invented by ISF RWTH Aachen. The Langmuir probe method is used for measurement. The relative simplicity of the method and the possibility of dispersion of high power on the probe allow its application for the investigation of high-power electron beams. The key element of the method is a rotating thin tungsten wire, which intersects the beam transversely on its axis and collects part of the current by itself. The signals, which are registered in the DIABEAM as a voltage, were taken in the form of amplitude. The conversion of the probe current into the distribution along the beam radius was realised using the Abel’s method. A voltage-current characteristic was built for the beam current. The local electron density as well as the electron temperature, the floating potential and the plasma potential were measured and calculated by means of this characteristic.
Y1  - 2012
U6  - https://doi.org/10.1063/1.3675874
SN  - 1089-7674 (E-Journal); 1070-664X (Print)
VL  - 19
IS  - 1
SP  - 1
EP  - 7
PB  - AIP Publishing
CY  - Melville, NY
ER  - 
TY  - JOUR
A1  - Lustfeld, H.
A1  - Pithan, C.
A1  - Reißel, Martin
T1  - Metallic electrolyte composites in the framework of the brick-layer model
JF  - Journal of the European Ceramic Society
N2  - It is well known that the already large dielectric constants of some electrolytes like BaTiO₃ can be enhanced further by adding metallic (e.g. Ni, Cu or Ag) nanoparticles. The enhancement can be quite large, a factor of more than 1000 is possible. The consequences for the properties will be discussed in the present paper applying a brick-layer model (BLM) for calculating dc-resistivities of thin layers and a modified one (PBLM) that includes percolation for calculating dielectric properties of these materials. The PBLM results in an at least qualitative description and understanding of the physical phenomena: This model gives an explanation for the steep increase of the dielectric constant below the percolation threshold and why this increase is connected to a dramatic decrease of the breakdown voltage as well as the ability of storing electrical energy. We conclude that metallic electrolyte composites like BaTiO₃ are not appropriate for energy storage.
Y1  - 2012
U6  - https://doi.org/10.1016/j.jeurceramsoc.2011.10.017
SN  - 0955-2219
VL  - 32
IS  - 4
SP  - 859
EP  - 864
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Raue, Markus
A1  - Schusser, Sebastian
A1  - Jeitner, C.
A1  - Breuer, L.
A1  - Wagner, P.
A1  - Poghossian, Arshak
A1  - Förster, Arnold
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
T1  - Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films
JF  - Physica Status Solidi  (a)
N2  - Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3–12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100763
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 839
EP  - 845
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Miyamoto, Ko-ichiro
A1  - Kaneko, Kazumi
A1  - Matsuo, Akira
A1  - Wagner, Torsten
A1  - Kanoh, Shiníchiro
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Miniaturized chemical imaging sensor system using an OLED display panel
JF  - Sensors and Actuators B: Chemical
N2  - The chemical imaging sensor is a semiconductor-based chemical sensor that can visualize the two-dimensional distribution of specific ions or molecules in the solution. In this study, we developed a miniaturized chemical imaging sensor system with an OLED display panel as a light source that scans the sensor plate. In the proposed configuration, the display panel is placed directly below the sensor plate and illuminates the back surface. The measured area defined by illumination can be arbitrarily customized to fit the size and the shape of the sample to be measured. The waveform of the generated photocurrent, the current–voltage characteristics and the pH sensitivity were investigated and pH imaging with this miniaturized system was demonstrated.
KW  - LAPS
KW  - Light-addressable potentiometric sensor
KW  - Chemical imaging sensor
KW  - Organic light-emitting diode display
Y1  - 2012
U6  - https://doi.org/10.1016/j.snb.2011.02.029
SN  - 0925-4005
N1  - Part of special issue "Eurosensors XXIV, 2010"
VL  - 170
SP  - 82
EP  - 87
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Verbanella, Stresa
A1  - Fabo, Sabine
T1  - Mit Pinsel und Farbe hacken : Interview mit Sabine Fabo
T1  - Hacking with paint and brush : interview with Sabine Fabo
JF  - Remotewords.net
N2  - Remotewords makes its mark on the picturesque "Bar Verbanella”, located in Stresa near Isola Bella on Lago Maggiore. The words CUM GRANO SALIS (with a grain of salt) by Sabine Fabo, art theorist on media contexts, were applied to its roof in collaboration with the German-Italian art organization "Lo spirito del Lago".
KW  - Guerrillawerbung
KW  - Parasitäre Strategie
Y1  - 2012
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - McEwan, Jillian
A1  - Beuger, Vincent
A1  - Stanley, Lesley A.
A1  - Rode, Anja
A1  - Wolf, C. Roland
T1  - Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines
JF  - Molecular Pharmacology
N2  - The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.
Y1  - 2012
U6  - https://doi.org/10.1124/mol.111.075192
SN  - 1521-0111
VL  - 81
IS  - 1
SP  - 63
EP  - 72
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Reisgen, Uwe
A1  - Schleser, Markus
A1  - Mokrov, Oleg
A1  - Zabirov, Alexander
A1  - Füssel, Uwe
A1  - Schnick, Michael
A1  - Hertel, Martin
A1  - Jaeckel, Sebastian
T1  - Modellierung und Visualisierung der MSG-Lichtbogenprozesse
JF  - Schweissen und Schneiden : Fachzeitschrift für Schweißen und verwandte Verfahren
Y1  - 2012
SN  - 0036-7184
VL  - 64
IS  - 4
SP  - 166
EP  - 174
PB  - DVS Verlag
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Reisgen, Uwe
A1  - Schleser, Markus
A1  - Mokrov, Oleg
A1  - Zabirov, Alexander
A1  - Füssel, Uwe
A1  - Schnick, Michael
A1  - Hertel, Martin
A1  - Jaeckel, Sebastian
T1  - Modelling and visualisation of the GMA process
JF  - Welding and Cutting
Y1  - 2012
SN  - 1612-3433
VL  - 11
IS  - 4
SP  - 242
EP  - 249
PB  - DVS Verlag
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Bohrn, U.
A1  - Stütz, E.
A1  - Fuchs, K.
A1  - Fleischer, M.
A1  - Schöning, Michael Josef
A1  - Wagner, P.
T1  - Monitoring of irritant gas using a whole-cell-based sensor system
JF  - Sensors and Actuators B: Chemical
N2  - Cell-based sensors for the detection of gases have long been underrepresented, due to the cellular requirement of being cultured in a liquid environment. In this work we established a cell-based gas biosensor for the detection of toxic substances in air, by adapting a commercial sensor chip (Bionas®), previously used for the measurement of pollutants in liquids. Cells of the respiratory tract (A549, RPMI 2650, V79), which survive at a gas phase in a natural context, are used as biological receptors. The physiological cell parameters acidification, respiration and morphology are continuously monitored in parallel. Ammonia was used as a highly water-soluble model gas to test the feasibility of the sensor system. Infrared measurements confirmed the sufficiency of the medium draining method. This sensor system provides a basis for many sensor applications such as environmental monitoring, building technology and public security.
Y1  - 2012
U6  - https://doi.org/10.1016/j.snb.2012.05.088
SN  - 0925-4005
VL  - 175
SP  - 208
EP  - 217
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Butenweg, Christoph
A1  - Holtschoppen, Britta
T1  - Neuer VCI-Leitfaden für die erdbebensichere Auslegung von Industrieanlagen
JF  - Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik
Y1  - 2012
SN  - 1436-4867 (E-Journal); 0005-6650 (Print)
VL  - Band 87
SP  - S18
PB  - VDI Fachmedien
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Trenz, Eva
A1  - Lohmann, Philipp
A1  - Frotscher, Ralf
A1  - Klinge, Uwe
A1  - Tabaza, Ruth
A1  - Kirschner-Hermanns, Ruth
T1  - New measurements to compare soft tissue anchoring systems in pelvic floor surgery
JF  - Journal of Biomedical Materials Research Part B: Applied Biomaterials
N2  - Suburethral slings as well as different meshes are widely used treating stress urinary incontinence and prolaps in women. With the development of MiniSlings and special meshes using less alloplastic material anchorage systems become more important to keep devices in place and to put some tension especially on the MiniSlings. To date, there are many different systems of MiniSlings of different companies on the market which differ in the structure of the used meshes and anchors. A new objective measurement method to compare different properties of MiniSling systems (mesh and anchor) is presented in this article. Ballistic gelatine acts as soft tissue surrogate. Significant differences in parameters like pull-out strength of anchors or shrinkage of meshes under loading conditions have been determined. The form and size of the anchors as well as the structural stability of the meshes are decisive for a proper integration. The tested anchorings sytems showed markedly different mechanical function at their respective load bearing capacity. As the stable fixation of the device in tissue is a prerequisite for a permanet reinforcement, the proposed test system permits further optimisation of anchor and mesh devices to improve the success of the surgical treatment
Y1  - 2012
U6  - https://doi.org/10.1002/jbm.b.32654
SN  - 1552-4981
VL  - 100B
IS  - 4
SP  - 924
EP  - 933
PB  - Wiley
CY  - Hoboken, NJ
ER  - 
TY  - JOUR
A1  - Iken, Heiko
A1  - Kirsanov, D.
A1  - Legin, A.
A1  - Schöning, Michael Josef
T1  - Novel Thin-Film Polymeric Materials for the Detection of Heavy Metals
JF  - Procedia Engineering
N2  - A variety of transition metals, e.g., copper, zinc, cadmium, lead, etc. are widely used in industry as components for wires, coatings, alloys, batteries, paints and so on. The inevitable presence of transition metals in industrial processes implies the ambition of developing a proper analytical technique for their adequate monitoring. Most of these elements, especially lead and cadmium, are acutely toxic for biological organisms. Quantitative determination of these metals at low activity levels in different environmental and industrial samples is therefore a vital task. A promising approach to achieve an at-side or on-line monitoring on a miniaturized and cost efficient way is the combination of a common potentiometric sensor array with heavy metal-sensitive thin-film materials, like chalcogenide glasses and polymeric materials, respectively.
Y1  - 2012
U6  - https://doi.org/10.1016/j.proeng.2012.09.148
SN  - 1877-7058
N1  - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012"
IS  - 47
SP  - 322
EP  - 325
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Werner, Frederik
A1  - Groebel, Simone
A1  - Krumbe, Christoph
A1  - Wagner, Torsten
A1  - Selmer, Thorsten
A1  - Yoshinobu, Tatsuo
A1  - Baumann, Marcus
A1  - Schöning, Michael Josef
T1  - Nutrient concentration-sensitive microorganism-based biosensor
JF  - Physica Status Solidi (a)
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100801
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 900
EP  - 904
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Olbertz, Klaus
A1  - Fahrig, Stephan
T1  - Offshoring als Betriebs(teil)übergang gemäß § 613a BGB
JF  - ZIP Zeitschrift für Wirtschaftsrecht
Y1  - 2018
SN  - 0723-9416
N1  - gedruckt in der Bereichsbibliothek Eupener Str. unter der Signatur 43 Z 548 vorhanden
IS  - 42
SP  - 2045
PB  - Verlag Dr. Otto Schmidt
CY  - Köln
ER  - 
TY  - JOUR
A1  - Aggarwal, Pranav
A1  - Dhiman, Shashi K.
A1  - Kumar, G.
A1  - Scherer, Ulrich W.
A1  - Singla, M. L.
A1  - Srivastava, Alok
T1  - Optical study of poly(ethyleneterephthalate) modified by different ionizing radiation dose
JF  - Indian Journal of Pure and Applied Physics
N2  - Thin films of poly(ethyleneterephthalate) [PET]were exposed to radiation dose ranging from 10 to 30 kGy by using gamma rays in the range 12.8-177.8 MGy using swift light ions of hydrogen. There was no effect of the radiation dose on the optical behaviour of PET as a result of exposure to radiation dose up to 30 kGy brought about by gamma rays but a significant decrease in the optical band gap values was observed when PET was exposed to swift light ions of hydrogen. The data obtained are discussed in terms of optical studies carried out on PET using swift heavy ions.
Y1  - 2012
SN  - 0019-5596
VL  - 50
IS  - 2
SP  - 129
EP  - 132
ER  -