TY - CHAP A1 - Macdonald, Malcolm A1 - McGrath, C. A1 - Appourchaux, T. A1 - Dachwald, Bernd A1 - Finsterle, W. A1 - Gizon, L. A1 - Liewer, P. C. A1 - McInnes, Colin R. A1 - Mengali, G. A1 - Seboldt, W. A1 - Sekii, T. A1 - Solanki, S. K. A1 - Velli, M. A1 - Wimmer-Schweingruber, R. F. A1 - Spietz, Peter A1 - Reinhard, Ruedeger ED - Macdonald, Malcolm T1 - Gossamer roadmap technology reference study for a solar polar mission T2 - Advances in solar sailing N2 - A technology reference study for a solar polar mission is presented. The study uses novel analytical methods to quantify the mission design space including the required sail performance to achieve a given solar polar observation angle within a given timeframe and thus to derive mass allocations for the remaining spacecraft sub-systems, that is excluding the solar sail sub-system. A parametric, bottom-up, system mass budget analysis is then used to establish the required sail technology to deliver a range of science payloads, and to establish where such payloads can be delivered to within a given timeframe. It is found that a solar polar mission requires a solar sail of side-length 100–125 m to deliver a ‘sufficient value’ minimum science payload, and that a 2.5 μm sail film substrate is typically required, however the design is much less sensitive to the boom specific mass. Y1 - 2014 SN - 978-3-642-34906-5 U6 - https://doi.org/10.1007/978-3-642-34907-2_17 SP - 243 EP - 257 PB - Springer CY - Berlin, Heidelberg ER - TY - JOUR A1 - Handtke, Stefan A1 - Schroeter, Rebecca A1 - Jürgen, Britta A1 - Methling, Karen A1 - Schlüter, Rabea A1 - Albrecht, Dirk A1 - Hijum, Sacha A. F. T. van A1 - Bongaerts, Johannes A1 - Maurer, Karl-Heinz A1 - Lalk, Michael A1 - Schweder, Thomas A1 - Hecker, Michael A1 - Voigt, Birgit T1 - Bacillus pumilus reveals a remarkably high resistance to hydrogen peroxide provoked oxidative stress JF - PLOS one N2 - Bacillus pumilus is characterized by a higher oxidative stress resistance than other comparable industrially relevant Bacilli such as B. subtilis or B. licheniformis. In this study the response of B. pumilus to oxidative stress was investigated during a treatment with high concentrations of hydrogen peroxide at the proteome, transcriptome and metabolome level. Genes/proteins belonging to regulons, which are known to have important functions in the oxidative stress response of other organisms, were found to be upregulated, such as the Fur, Spx, SOS or CtsR regulon. Strikingly, parts of the fundamental PerR regulon responding to peroxide stress in B. subtilis are not encoded in the B. pumilus genome. Thus, B. pumilus misses the catalase KatA, the DNA-protection protein MrgA or the alkyl hydroperoxide reductase AhpCF. Data of this study suggests that the catalase KatX2 takes over the function of the missing KatA in the oxidative stress response of B. pumilus. The genome-wide expression analysis revealed an induction of bacillithiol (Cys-GlcN-malate, BSH) relevant genes. An analysis of the intracellular metabolites detected high intracellular levels of this protective metabolite, which indicates the importance of bacillithiol in the peroxide stress resistance of B. pumilus. Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0085625 SN - 1932-6203 VL - 9 IS - 1 PB - PLOS CY - San Francisco ER - TY - BOOK A1 - Laack, Walter van T1 - Schnittstelle Tod: Was spricht für unser Weiterleben? Y1 - 2014 SN - 978-3-936624-19-9 N1 - Walter van Laack [Hrsg.] PB - van Laack CY - Aachen ER - TY - JOUR A1 - Beck, Daniel A1 - Buchleitner, Martin A1 - Ferrein, Alexander A1 - Niemüller, Tim A1 - Steinbauer, Gerald T1 - Mostly Harmless & AllemaniACs - mixed innovations Y1 - 2014 SP - 1 EP - 8 ER - TY - BOOK A1 - Timme, Michael T1 - Wohnungseigentumsgesetz : Gesetz über das Wohnungseigentum und das Dauerwohnrecht; Kommentar / Timme [Hrsg.] Y1 - 2014 SN - 978-3-406-66025-2 PB - Beck CY - München ET - 2. Aufl. ER - TY - JOUR A1 - Timme, Michael T1 - BGH: Geltendmachung von Sachmängeln bei Wohnungseigentum JF - LMK : Fachdienst Zivilrecht : Kommentierte BGH-Rechtsprechung Y1 - 2014 SN - 1611-1095 N1 - Kostenlose Registrierung erforderlich VL - 2014 IS - 5 PB - Beck CY - München ER - TY - CHAP A1 - Timme, Michael T1 - Begriffsbestimmungen T2 - Wohnungseigentumsgesetz : Gesetz über das Wohnungseigentum und das Dauerwohnrecht ; Kommentar Y1 - 2014 SN - 978-3-406-66025-2 SP - 1 EP - 23 PB - Beck CY - München ET - 2. Auflage ER - TY - JOUR A1 - Fiedler, Gerda A1 - Henn, Gudrun A1 - Melcher, Karin T1 - ANPAK - ein semesterbegleitender Anpassungskurs JF - Zeitschrift für Hochschulentwicklung N2 - In Folge mehrjähriger statistischer Untersuchungen an der FH Aachen ist unter anderem ein Eingangstest entstanden, der als Diagnosetool für einen erfolgreichen Studieneinstieg verwendet wird. Es hat sich herausgestellt, dass ein Testergebnis von weniger als 25 (von maximal 56 erreichbaren) Punkten die Chance auf einen erfolgreichen Studieneinstieg deutlich verringert. Ungefähr die Hälfte aller Erstsemester hat weniger als 25 Punkte im Eingangstest. Weniger als 20 % dieser Gruppe bestehen innerhalb eines Jahres die Klausur Mathematik 1. Die investierte Zeit von zwei Semestern ist mit Blick auf den Wissenszuwachs und damit letztendlich den Studienerfolg nicht effizient genutzt. Deshalb haben wir im WS 2013/14 einen semesterbegleitenden Anpassungskurs für diese Gruppe installiert. Ziel eines solchen Kurses ist es, die Student/innen innerhalb eines Jahres in die Lage zu versetzen, nach zwei Semestern problemlos den Vorlesungen in Mathematik zu folgen. Dieser Artikel beschreibt das Konzept dieses Anpassungskurses und zeigt erste Ergebnisse und Probleme des Pilotdurchgangs auf. Y1 - 2014 SN - 2219-6994 VL - 9 IS - 4 SP - 85 EP - 100 PB - ÖGHD CY - Wien ER - TY - CHAP A1 - Kirchner, Patrick A1 - Reisert, Steffen A1 - Schöning, Michael Josef T1 - Calorimetric gas sensors for hydrogen peroxide monitoring in aseptic food processes T2 - Gas sensing fundamentals. (Springer Series on Chemical Sensors and Biosensors ; 15) N2 - For the sterilisation of aseptic food packages it is taken advantage of the microbicidal properties of hydrogen peroxide (H2O2). Especially, when applied in vapour phase, it has shown high potential of microbial inactivation. In addition, it offers a high environmental compatibility compared to other chemical sterilisation agents, as it decomposes into oxygen and water, respectively. Due to a lack in sensory detection possibilities, a continuous monitoring of the H2O2 concentration was recently not available. Instead, the sterilisation efficacy is validated using microbiological tests. However, progresses in the development of calorimetric gas sensors during the last 7 years have made it possible to monitor the H2O2 concentration during operation. This chapter deals with the fundamentals of calorimetric gas sensing with special focus on the detection of gaseous hydrogen peroxide. A sensor principle based on a calorimetric differential set-up is described. Special emphasis is given to the sensor design with respect to the operational requirements under field conditions. The state-of-the-art regarding a sensor set-up for the on-line monitoring and secondly, a miniaturised sensor for in-line monitoring are summarised. Furthermore, alternative detection methods and a novel multi-sensor system for the characterisation of aseptic sterilisation processes are described. KW - Calorimetric gas sensor KW - Hydrogen peroxide KW - Multi-sensor system Y1 - 2014 SN - 978-3-642-54518-4 (Print) ; 978-3-642-54519-1 (Online) U6 - https://doi.org/10.1007/5346_2013_51 SP - 279 EP - 309 PB - Springer CY - Heidelberg ER - TY - CHAP A1 - Schöning, Michael Josef A1 - Poghossian, Arshak A1 - Glück, Olaf A1 - Thust, Marion T1 - Electrochemical methods for the determination of chemical variables in aqueous media T2 - Measurement, instrumentation, and sensors handbook / ed. by John G. Webster [u.a.] Vol. 2 : Electromagnetic, optical, radiation, chemical, and biomedical measurement Y1 - 2014 SN - 978-1-4398-4891-3 SP - 55-1 EP - 55-54 PB - CRC Pr. CY - Boca Raton, Fla. ER - TY - JOUR A1 - Nachtrodt, Frederik A1 - Tietsch, Wolfgang A1 - Mostacci, Domiziano A1 - Scherer, Ulrich W. T1 - Set-up and first operation of a plasma oven for treatment of low level radioactive wastes JF - Nuclear technology and radiation protection Y1 - 2014 U6 - https://doi.org/10.2298/NTRP140SS47N SN - 1451-3994 VL - 29 IS - Suppl. SP - 47 EP - 51 PB - VINČA Institute of Nuclear Sciences CY - Belgrad ER - TY - JOUR A1 - Fateri, Miranda A1 - Gebhardt, Andreas A1 - Thümmler, Stefan A1 - Thurn, Laura T1 - Experimental investigation on selective laser melting of glass JF - Physics procedia : 8th International Conference on Laser Assisted Net Shape Engineering LANE 2014 Y1 - 2014 U6 - https://doi.org/10.1016/j.phpro.2014.08.118 SN - 1875-3892 (E-Journal); 1875-3884 (Print) VL - 56 (2014) SP - 357 EP - 364 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Srivastava, A. A1 - Lahiri, S. A1 - Maiti, M. A1 - Knolle, F. A1 - Hoyler, Friedrich A1 - Scherer, Ulrich W. A1 - Schnug, E. W. T1 - Study of naturally occurring radioactive material (NORM) in top soil of Punjab State from the North Western part of India JF - Journal of Radioanalytical and Nuclear Chemistry Y1 - 2014 U6 - https://doi.org/0.1007/s10967-014-3450-1 SN - 1588-2780 (E-Journal); 0022-4081 (Print); 0134-0719 (Print); 0236-5731 (Print); 1417-2097 (Print) VL - 2014 IS - 302 SP - 1049 EP - 1052 PB - Springer Nature CY - Basel ER - TY - JOUR A1 - Siqueira, Jose R. A1 - Molinnus, Denise A1 - Beging, Stefan A1 - Schöning, Michael Josef T1 - Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection JF - Analytical chemistry N2 - The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor’s surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance–voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform. Y1 - 2014 U6 - https://doi.org/10.1021/ac500458s SN - 1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print) VL - 86 IS - 11 SP - 5370 EP - 5375 PB - ACS Publications CY - Columbus ER - TY - JOUR A1 - Murib, Mohammed Sharif A1 - Yeap, Weng-Siang A1 - Martens, Daan A1 - Bienstman, Peter A1 - Ceuninck, Ward de A1 - Grinsven, Bart van A1 - Schöning, Michael Josef A1 - Michiels, Luc A1 - Haenen, Ken A1 - Ameloot, Marcel A1 - Serpengüzel, Ali A1 - Wagner, Patrick T1 - Photonic detection and characterization of DNA using sapphire microspheres JF - Journal of biomedical optics N2 - A microcavity-based deoxyribonucleic acid (DNA) optical biosensor is demonstrated for the first time using synthetic sapphire for the optical cavity. Transmitted and elastic scattering intensity at 1510 nm are analyzed from a sapphire microsphere (radius 500  μm, refractive index 1.77) on an optical fiber half coupler. The 0.43 nm angular mode spacing of the resonances correlates well with the optical size of the sapphire sphere. Probe DNA consisting of a 36-mer fragment was covalently immobilized on a sapphire microsphere and hybridized with a 29-mer target DNA. Whispering gallery modes (WGMs) were monitored before the sapphire was functionalized with DNA and after it was functionalized with single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The shift in WGMs from the surface modification with DNA was measured and correlated well with the estimated thickness of the add-on DNA layer. It is shown that ssDNA is more uniformly oriented on the sapphire surface than dsDNA. In addition, it is shown that functionalization of the sapphire spherical surface with DNA does not affect the quality factor (Q≈104) of the sapphire microspheres. The use of sapphire is especially interesting because this material is chemically resilient, biocompatible, and widely used for medical implants. Y1 - 2014 U6 - https://doi.org/10.1117/1.JBO.19.9.097006 SN - 1560-2281 (E-Journal); 1083-3668 (Print) VL - 19 IS - 9 SP - 097006 PB - SPIE CY - Bellingham ER - TY - JOUR A1 - Handtke, Stefan A1 - Volland, Sonja A1 - Methling, Karen A1 - Albrecht, Dirk A1 - Becher, Dörte A1 - Nehls, Jenny A1 - Bongaerts, Johannes A1 - Maurer, Karl-Heinz A1 - Lalk, Michael A1 - Liesegang, Heiko A1 - Voigt, Birgit A1 - Daniel, Rolf A1 - Hecker, Michael T1 - Cell physiology of the biotechnological relevant bacterium Bacillus pumilus - An omics-based approach JF - Journal of Biotechnology N2 - Members of the species Bacillus pumilus get more and more in focus of the biotechnological industry as potential new production strains. Based on exoproteome analysis, B. pumilus strain Jo2, possessing a high secretion capability, was chosen for an omics-based investigation. The proteome and metabolome of B. pumilus cells growing either in minimal or complex medium was analyzed. In total, 1542 proteins were identified in growing B. pumilus cells, among them 1182 cytosolic proteins, 297 membrane and lipoproteins and 63 secreted proteins. This accounts for about 43% of the 3616 proteins encoded in the B. pumilus Jo2 genome sequence. By using GC–MS, IP-LC/MS and H NMR methods numerous metabolites were analyzed and assigned to reconstructed metabolic pathways. In the genome sequence a functional secretion system including the components of the Sec- and Tat-secretion machinery was found. Analysis of the exoproteome revealed secretion of about 70 proteins with predicted secretion signals. In addition, selected production-relevant genome features such as restriction modification systems and NRPS clusters of B. pumilus Jo2 are discussed. Y1 - 2014 U6 - https://doi.org/10.1016/j.jbiotec.2014.08.028 SN - 1873-4863 (E-Journal); 0168-1656 (Print) IS - 192(A) SP - 204 EP - 214 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Pieper, Martin A1 - Schulz, Silvia T1 - Teaching Simulation Methods with COMSOL Multiphysics N2 - This paper describes two courses on simulation methods for graduate students: “Simulation Methods” and “Simulation and Optimization in Virtual Engineering” The courses were planned to teach young engineers how to work with simulation software as well as to understand the necessary mathematical background. As simulation software COMSOL is used. The main philosophy was to combine theory and praxis in a way that motivates the students. In addition “soft skills” should be improved. This was achieved by project work as final examination. As underlying didactical principle the ideas of Bloom’s revised taxonomy were followed. The paper basically focusses on educational aspects, e.g. how to structure the course, plan the exercises, organize the project work and include practical COMSOL examples. KW - COMSOL Multiphysics KW - Optimization module KW - LiveLink for MATLAB KW - Bloom Taxonomy KW - education Y1 - 2014 ER - TY - JOUR A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Stresses produced by different textile mesh implants in a tissue equivalent JF - BioNanoMaterials N2 - Two single-incision mini-slings used for treating urinary incontinence in women are compared with respect to the stresses they produce in their surrounding tissue. In an earlier paper we experimentally observed that these implants produce considerably different stress distributions in a muscle tissue equivalent. Here we perform 2D finite element analyses to compare the shear stresses and normal stresses in the tissue equivalent for the two meshes and to investigate their failure behavior. The results clearly show that the Gynecare TVT fails for increasing loads in a zipper-like manner because it gradually debonds from the surrounding tissue. Contrary to that, the tissue at the ends of the DynaMesh-SIS direct may rupture but only at higher loads. The simulation results are in good agreement with the experimental observations thus the computational model helps to interpret the experimental results and provides a tool for qualitative evaluation of mesh implants. Y1 - 2014 U6 - https://doi.org/10.1515/bnm-2014-0003 SN - 2191-4672 (E-Journal); 2193-066X (E-Journal); 0011-8656 (Print); 1616-0177 (Print); 2193-0651 (Print) VL - 15 IS - 1-2 SP - 25 EP - 30 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Alhwarin, Faraj A1 - Ferrein, Alexander A1 - Scholl, Ingrid T1 - IR stereo kinect: improving depth images by combining structured light with IR stereo Y1 - 2014 SP - 1 EP - 9 ER - TY - JOUR A1 - Guo, Yuanyuan A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Device simulation of the light-addressable potentiometric sensor for the investigation of the spatial resolution JF - Sensors and actuators B: Chemical N2 - As a semiconductor-based electrochemical sensor, the light-addressable potentiometric sensor (LAPS) can realize two dimensional visualization of (bio-)chemical reactions at the sensor surface addressed by localized illumination. Thanks to this imaging capability, various applications in biochemical and biomedical fields are expected, for which the spatial resolution is critically significant. In this study, therefore, the spatial resolution of the LAPS was investigated in detail based on the device simulation. By calculating the spatiotemporal change of the distributions of electrons and holes inside the semiconductor layer in response to a modulated illumination, the photocurrent response as well as the spatial resolution was obtained as a function of various parameters such as the thickness of the Si substrate, the doping concentration, the wavelength and the intensity of illumination. The simulation results verified that both thinning the semiconductor substrate and increasing the doping concentration could improve the spatial resolution, which were in good agreement with known experimental results and theoretical analysis. More importantly, new findings of interests were also obtained. As for the dependence on the wavelength of illumination, it was found that the known dependence was not always the case. When the Si substrate was thick, a longer wavelength resulted in a higher spatial resolution which was known by experiments. When the Si substrate was thin, however, a longer wavelength of light resulted in a lower spatial resolution. This finding was explained as an effect of raised concentration of carriers, which reduced the thickness of the space charge region. The device simulation was found to be helpful to understand the relationship between the spatial resolution and device parameters, to understand the physics behind it, and to optimize the device structure and measurement conditions for realizing higher performance of chemical imaging systems. Y1 - 2014 U6 - https://doi.org/10.1016/j.snb.2014.08.016 SN - 1873-3077 (E-Journal); 0925-4005 (Print) VL - 204 SP - 659 EP - 665 PB - Elsevier CY - Amsterdam ER -