TY - JOUR A1 - Allefeld, Carsten A1 - Bialonski, Stephan T1 - Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains JF - Physical Review E Y1 - 2007 U6 - https://doi.org/10.1103/PhysRevE.76.066207 SN - 2470-0053 VL - 76 IS - 6 SP - 066207 ER - TY - JOUR A1 - Almajhdi, Fahad N. A1 - Senger, Tilo A1 - Amer, Haitham M. A1 - Gissmann, Lutz A1 - Öhlschläger, Peter T1 - Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling) JF - PLOS one N2 - Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism. Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0113461 SN - 1932-6203 VL - 11 IS - 9 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Alnemer, Momin Sami Mohammad A1 - Kotliar, Konstantin A1 - Neuhaus, Valentin A1 - Pape, Hans-Christoph A1 - Ciritsis, Bernhard D. T1 - Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model JF - Cost Effectiveness and Resource Allocation N2 - Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare & Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10% fracture risk reduction, model A costs between $8,850 and $46,940 per quality-adjusted life-year ($/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side’s prophylaxis, the patient’s age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between $11,000/QALY and $74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks. KW - Hip fractures KW - Prevention KW - Geriatric KW - Cost-effectiveness KW - Prophylaxis Y1 - 2023 U6 - https://doi.org/10.1186/s12962-023-00482-4 SN - 1478-7547 N1 - Corresponding author: Momin S. Alnemer IS - 21, Article number: 77 PB - Springer Nature ER - TY - JOUR A1 - Alt, Helmut T1 - Spannungs-Blindleistungs-Regelung mit gesteuerten Netzkennlinien JF - Elektrotechnische Zeitschrift : Ausgabe A, Zeitschrift für elektrische Energietechnik : ETZ Y1 - 1976 SN - 0302-265x VL - 97 IS - 7 SP - 441 EP - 446 PB - VDE-Verlag CY - Wuppertal ER - TY - JOUR A1 - Alt, Helmut T1 - Netzanschlußmöglichkeiten und energiewirtschaftliche Bewertung von Windkraftanlagen JF - Elektrizitätswirtschaft Y1 - 1995 SN - 0013-5496 VL - Jg. 94 IS - H. 19 SP - 1224 EP - 1234 ER - TY - JOUR A1 - Alt, Helmut T1 - Benchmark der Netznutzungspreise JF - Energiewirtschaftliche Tagesfragen : et ; Zeitschrift für Energiewirtschaft, Recht, Technik und Umwelt Y1 - 2000 SN - 0013-743X VL - Bd. 50 IS - H. 11 SP - 846 EP - 850 ER - TY - JOUR A1 - Alt, Helmut T1 - Die Bedeutung des Effektivzinses in der Finanzwirtschaft JF - Betriebs-Berater : BB : Beil. 14 Finanz-Berater Y1 - 1989 SN - 0340-7926 N1 - Printausg. in der Bibliothek vorhanden: 43 Z 228 SP - 31 EP - 32 ER - TY - JOUR A1 - Alt, Helmut T1 - Einfluß der Kontoführungsmodelle auf den Effektivzins und die Restschuld bei Annuitätendarlehen JF - Betriebs-Berater : BB : Beil. 14 Finanz-Berater Y1 - 1989 SN - 0340-7926 N1 - Printausg. in der Bibliothek vorhanden: 43 Z 228 SP - 32 EP - 37 ER - TY - JOUR A1 - Alt, Helmut T1 - Belieferung von Kunden in fremden Netzgebieten JF - EW : das Magazin für die Energie-Wirtschaft Y1 - 2002 SN - 0013-5496 N1 - Printausg. in der Bibliothek vorhanden: 23 Z 585 VL - Bd. 101 IS - H. 1/2 SP - 26 EP - 35 ER - TY - JOUR A1 - Alt, Helmut T1 - Wunschphantasie eines eingefleischten Kernenergiegegners : zur Rede von Bundesumweltminister Jürgen Trittin auf dem VDEW-Kongress 2005 "Die Energieversorgung der Zukunft" JF - EW : das Magazin für die Energie-Wirtschaft Y1 - 2005 SN - 0013-5496 N1 - Printausg. in der Bibliothek vorhanden: 23 Z 585 VL - Bd. 104 IS - H. 17/18 SP - 7 ER - TY - JOUR A1 - Alt, Helmut T1 - Versorgungssicherheit und Windenergie : Tatsachen und Fakten statt Mythen und Mysterien JF - EW : das Magazin für die Energie-Wirtschaft Y1 - 2005 SN - 0013-5496 N1 - Printaus. in der Bibliothek vorhanden: 23 Z 585 VL - Bd. 104 IS - H. 25 SP - 42 EP - 45 ER - TY - JOUR A1 - Alt, Helmut T1 - Die Sonne bestimmt zunehmend die Spannung in der Steckdose : Lastflussberechnung einer Photovoltaikeinspeisung JF - EW : das Magazin für die Energie-Wirtschaft Y1 - 2011 SN - 0013-5496 N1 - Printausg. in der Bibliothek vorhanden: 23 Z 585 VL - Bd. 110 IS - H. 17/18 SP - 24 EP - 29 PB - VWEW-Energieverlag CY - Frankfurt, M. ER - TY - JOUR A1 - Alt, Helmut T1 - Entwicklungstendenzen der Sicherheit und der notwendigen Reserveleistung beim Verbundbetrieb der Kraftwerke JF - Elektrizitätswirtschaft Y1 - 1970 SN - 0013-5496 VL - 69 IS - 25 SP - 672 EP - 678 PB - VWEW-Energieverlag CY - Frankfurt/Main ER - TY - JOUR A1 - Alt, Helmut T1 - Digitale Berechnung der Betriebsdiagramme von Hochspannungsleitungen JF - Elektrizitätswirtschaft Y1 - 1972 SN - 0013-5496 VL - 71 IS - 4 SP - 87 EP - 92 PB - VWEW-Energieverlag CY - Frankfurt/Main ER - TY - JOUR A1 - Alt, Helmut T1 - Auswertung von Prüfungsergebnissen auf elektronischen Rechenanlagen JF - Angewandte Informatik Y1 - 1974 SN - 0013-5704 VL - 16 IS - 5 SP - 219 EP - 222 PB - Vieweg CY - Braunschweig ER - TY - JOUR A1 - Alt, Helmut T1 - Tabellenfreie Berechnung der Einkommensteuer mit Hilfe des programmierbaren Taschenrechners JF - Elektrizitätswirtschaft Y1 - 1978 SN - 0013-5496 VL - 77 SP - 486 EP - 489 PB - VWEW-Energieverlag CY - Frankfurt/Main ER - TY - JOUR A1 - Alt, Helmut T1 - Wirtschaftlichkeit von Investitionen JF - Elektrizitätswirtschaft Y1 - 1978 SN - 0013-5496 VL - 77 IS - 3 SP - 73 EP - 76 PB - VWEW-Energieverlag CY - Frankfurt/Main ER - TY - JOUR A1 - Alt, Helmut T1 - Isolierte Freileitungen, ein Betriebsmittel für schwierige Trassenführung JF - Elektrizitätswirtschaft Y1 - 1979 SN - 0013-5496 VL - Jg. 78 IS - H. 10 SP - 250 EP - 256 ER - TY - JOUR A1 - Alt, Helmut T1 - Kurzschlußstromberechnung JF - Elektrizitätswirtschaft Y1 - 1980 SN - 0013-5496 VL - Jg. 79 IS - H. 10 SP - 379 EP - 382 ER - TY - JOUR A1 - Alt, Helmut T1 - Wirtschaftlichkeitsberechnung von Investitionen mit dem programmierbaren Taschenrechner JF - 3 R international : RRR ; Rohre, Rohrleitungsbau, Rohrleitungstransport Y1 - 1981 SN - 0340-3386 VL - Jg. 20 IS - H. 10 SP - 561 EP - 565 ER -