TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Tomasberger, T.
A1  - Veltkamp, T. C.
A1  - Booij, A. S.
T1  - Radiocesium Removal from High Level Liquid Waste and Immobilisation in Sodium SilicoTitanate for Geological Disposal / T. Tomasberger, T.C. Veltkamp, A.S. Booij, U.W. Scherer
JF  - Radiochimica Acta. 89 (2001), H. 3
Y1  - 2001
SN  - 0033-8230
SP  - 145
EP  - 150
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Srivastava, Alok
A1  - Singh, Vivendra
A1  - Chandra, Amita
T1  - Electrical conductivity studies of swift heavy ion modified PVC and PVC-PANI composite / Alok Srivastava ,Virendra Singh, Amita Chandra, K.Witte, U.W.Scherer and T.V.Singh
JF  - Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 245 (2006), H. 1
Y1  - 2006
SN  - 0168-583X
SP  - 277
EP  - 280
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Schädel, M.
A1  - Brüchle, W.
A1  - Schimpf, E.
T1  - Chemical Properties of Element 105 in Aqueous Solution: Cation Exchange Separations with α-Hydroxyisobutyric Acid / M. Schädel, W. Brüchle, E. Schimpf, H.P. Zimmermann, M.K. Gober, J.V. Kratz,  N. Trautmann, H. Gäggeler, D. Jost, J. Kovacs, U.W. Sche
JF  - Radiochimica Acta. 57 (1992)
Y1  - 1992
SN  - 0033-8230
SP  - 85
EP  - 92
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Schädel, M.
A1  - Brüchle, W.
A1  - Jäger, E.
T1  - ARCA II - A New Apparatus for Fast Repetitive HPLC-Separations / M. Schädel, W. Brüchle, E. Jäger, E. Schimpf, J.V. Kratz, U.W. Scherer, H.P. Zimmermann
JF  - Radiochimica Acta. 48 (1989)
Y1  - 1989
SN  - 0033-8230
SP  - 171
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Santana, H. H. S.
A1  - Maier, G.
A1  - Rodenas, J.
T1  - Analysis of mechanical strength in ceramic pellets of nuclear fuel  / Santana, H. H. S. ; Maier, G. ; Scherer, U. W. ; Rodenas, J.
JF  - Radiation effects and defects in solids. 164 (2009), H. 5-6
Y1  - 2009
SN  - 1042-0150
SP  - 313
EP  - 318
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Kratz, J. V.
A1  - Zimmermann, H. P.
A1  - Schädel, M.
T1  - Chemical Properties of Element 105 in Aqueous Solutions: Halide Complex Formation and Anion Exchange into Triisooctylamine / J.V. Kratz, H.P. Zimmermann, U.W. Scherer, M. Schädel, W. Brüchle, K.E. Gregorich, C.M. Gannett, H.L. Hall, R.A. Henderson, D.M. L
JF  - Radiochimica Acta. 48 (1989)
Y1  - 1989
SN  - 0033-8230
SP  - 121
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Kratz, J. V.
A1  - Schädel, M.
A1  - Brüchle, W.
T1  - Lawrencium Chemistry: No Evidence for Oxidation States Lower than 3+ in Aqueous Solution / U.W. Scherer, J.V. Kratz, M. Schädel, W. Brüchle, K.E. Gregorich, R.A. Henderson, D. Lee, M. Nurmia, D.C. Hoffman
JF  - Inorganica Chimica Acta. 146 (1988)
Y1  - 1988
SN  - 0020-1693
SP  - 249
EP  - 254
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Kratz, J. V.
A1  - Gober, M. K.
A1  - Zimmermann, H. P.
T1  - New nuclide 263 105 / J.V. Kratz, M.K. Gober, H.P. Zimmermann, M. Schädel, W. Brüchle, E. Schimpf, K.E. Gregorich, A. Türler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M.J. Nurmia, D.C. Hoffman, H. Gäggeler, D. Jost, U.W. Scherer, A. Weber
JF  - Physical Review C . 45 (1992)
Y1  - 1992
SP  - 1064
EP  - 1069
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Jacobi, M.
A1  - Castillo, J.
A1  - Foerstel, D. H.
T1  - Ultra-low-level measurements of 3H and 14C in wines and champagne / Scherer, U. W. ; Jacobi, M. ; Castillo, J. ; Foerstel, D. H.
JF  - Radiation effects and defects in solids. 164 (2009), H. 5-6
Y1  - 2009
SN  - 1042-0150
SP  - 382
EP  - 385
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Hör, G.
A1  - Kranert, W. T.
A1  - Maul, F. D.
T1  - Gated Metabolic Positron Emission Tomography (GAPET) of Myocardium: 18F-FDG/PET to optimize Recognition of Myocardial Hibernation / G. Hör, W.T. Kranert, F.D. Maul, O. Schröder,  A. Karimian-Tatriz, O. Geb, R.P. Baum, U.W.  Scherer
JF  - Nuclear Medicine Communications. 19 (1998)
Y1  - 1998
SN  - 0143-3636
SP  - 535
EP  - 545
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Hör, G.
T1  - Artifacts and Pitfalls in FDG-PET Whole-Body Scans / U.W. Scherer, G. Hör
JF  - Radionuclides for Mammary Gland - Current Status and Future Aspects / G. S. Limouris [Hrsg.]
Y1  - 1997
SN  - 960-85227-6-5
SP  - 37
EP  - 42
PB  - Mediterra Publishers
CY  - Athen
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Heßberger, F. P.
A1  - Gäggeler, H. W.
A1  - Armbruster, P.
T1  - The New Nuclide 225U / F.P. Heßberger, H. Gäggeler, P. Armbruster, W. Brüchle, H. Folger, S. Hofmann, D. Jost, J.V. Kratz, M.E. Leino, G. Münzenberg, V. Ninov, M. Schädel, U.W. Scherer, K. Sümmerer, A. Türler, D. Ackerman
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 333 (1989), H. 1
Y1  - 1989
SN  - 0939-7922
SP  - 111
EP  - 112
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Gäggeler, H. W.
A1  - Jost, D. T.
A1  - Türler, A.
T1  - Cold Fusion Reactions with 48Ca / H.W. Gäggeler, D.T. Jost, A. Türler, P. Armbruster, W. Brüchle, H. Folger, F.P. Heßberger, S. Hofmann, G. Münzenberg, V. Ninov, W. Reisdorf, M. Schädel, K. Sümmerer, J.V. Kratz, U. Scherer, M.E. Leino
JF  - Nuclear Physics A . 502 (1989), H. 1
Y1  - 1989
SN  - 0375-9474
SP  - 561
EP  - 570
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Gäggeler, H. W.
A1  - Jost, D. T.
A1  - Kovacs, J.
T1  - Gas Phase Chromatography Experiments with Bromides of Tantalum and Element 105 / H.W. Gäggeler, D.T. Jost, J. Kovacs, U.W. Scherer, A. Weber, D. Vermeulen, A. Türler, K.E. Gregorich, R.A. Henderson, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M. Nurmia, D.
JF  - Radiochimica Acta. 57 (1992)
Y1  - 1992
SN  - 0033-8230
SP  - 93
EP  - 100
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Gober, M. K.
A1  - Kratz, J. V.
A1  - Zimmermann, H. P.
T1  - Chemical Properties of Element 105 in Aqueous Solution: Extractions into Diisobutylcarbinol / M.K. Gober, J.V. Kratz, H.P. Zimmermann, M. Schädel, W. Brüchle, E. Schimpf, K.E. Gregorich, A. Türler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee,
JF  - Radiochimica Acta. 57 (1992)
Y1  - 1992
SN  - 0033-8230
SP  - 77
EP  - 84
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Brüchle, W.
A1  - Schädel, M.
A1  - Kratz, J. V.
T1  - The Hydration Enthalpies of Md3+ and Lr3+ / W. Brüchle, M. Schädel, U.W. Scherer, J.V. Kratz, K.E. Gregorich, D. Lee, M. Nurmia, R.M. Chasteler, H.L. Hall, R.A. Henderson, D.C. Hoffman
JF  - Inorganica Chimica Acta. 146 (1988), H. 2
Y1  - 1988
SN  - 0020-1693
SP  - 267
EP  - 276
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Brüchle, W.
A1  - Brügger, M.
A1  - Frink, C.
T1  - Reactions of 40Ar with 233U,,235U, and 238U at the Barrier / U.W. Scherer, W. Brüchle, M. Brügger, C. Frink, H. Gäggeler, G. Herrmann, J.V. Kratz, K.J. Moody, M. Schädel, K. Sümmerer, N. Trautmann, G. Wirth
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 335 (1990), H. 4
Y1  - 1990
SN  - 0939-7922
SP  - 421
EP  - 430
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Baltensperger, Urs
A1  - Ammann, Markus
A1  - Bochert, Ulrich K.
T1  - Use of 13N for Studies of the Selective Reduction of NO by NH3 over Vanadia/Titania Catalyst at Very Low Reactant Concentrations / Urs Baltensperger, Markus Ammann, Ulrich K. Bochert, Bernd Eichler, Heinz W. Gäggeler, Dieter T. Jost, Joseph A. Kovacs,  An
JF  - Journal of Physical Chemistry. 97 (1993)
Y1  - 1993
SN  - 0022-3654
SP  - 12325
EP  - 12330
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
T1  - Controlled ion track etching / J. George;  M. Irkens ;  S. Neumann ;  U. W. Scherer ;  A. Srivastava ;  D. Sinha ; D. Fink
JF  - Radiation Effects and Defects in Solids. 161 (2006), H. 3
Y1  - 2006
SP  - 161
EP  - 175
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications
JF  - Xenobiotica
N2  - 1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug–drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described.

2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created.

3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug–drug interactions as well as in human metabolite testing and risk assessment.

4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.
KW  - transporters
KW  - human metabolites
KW  - drug metabolising enzymes
KW  - drug–drug interactions
KW  - bioavailability
Y1  - 2014
U6  - https://doi.org/10.3109/00498254.2013.815831
SN  - 1366-5928
VL  - 44
IS  - 2
SP  - 96
EP  - 108
PB  - Taylor & Francis
CY  - Abingdon
ER  -