TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Tastambek, Kuanysh T. A1 - Sherelkhan, Dinara K. A1 - Jussupova, Dariya B. A1 - Altynbay, Nazym P. T1 - Low-rank coal as a source of humic substances for soil amendment and fertility management JF - Agriculture N2 - Humic substances (HS), as important environmental components, are essential to soil health and agricultural sustainability. The usage of low-rank coal (LRC) for energy generation has declined considerably due to the growing popularity of renewable energy sources and gas. However, their potential as soil amendment aimed to maintain soil quality and productivity deserves more recognition. LRC, a highly heterogeneous material in nature, contains large quantities of HS and may effectively help to restore the physicochemical, biological, and ecological functionality of soil. Multiple emerging studies support the view that LRC and its derivatives can positively impact the soil microclimate, nutrient status, and organic matter turnover. Moreover, the phytotoxic effects of some pollutants can be reduced by subsequent LRC application. Broad geographical availability, relatively low cost, and good technical applicability of LRC offer the advantage of easy fulfilling soil amendment and conditioner requirements worldwide. This review analyzes and emphasizes the potential of LRC and its numerous forms/combinations for soil amelioration and crop production. A great benefit would be a systematic investment strategy implicating safe utilization and long-term application of LRC for sustainable agricultural production. KW - soil remediation KW - crop yield KW - soil health KW - soil amendment KW - low-rank coal Y1 - 2021 U6 - http://dx.doi.org/10.3390/agriculture11121261 SN - 2077-0472 N1 - This article belongs to the Special Issue "From Waste to Fertilizer in Sustainable Agriculture" VL - 11 IS - 12 PB - MDPI CY - Basel ER - TY - JOUR A1 - Dachwald, Bernd A1 - Carnelli, I. A1 - Vasile, M. T1 - Low-Thrust Gravity Assist Trajectory Optimization Using Evolutionary Neurocontrollers / I. Carnelli ; B. Dachwald ; M. Vasile ... JF - Astrodynamics 2005 : proceedings of the AAS/AIAA astrodynamics conference held August 7 - 11, 2005, South Lake Tahoe, California / ed. by Bobby G. Williams. - Pt. 3. - (Advances in the astronautical sciences ; 123,3) Y1 - 2006 SN - 0-87703-527-X N1 - Astrodynamics Conference <2005, South Lake Tahoe, Calif.> ; American Astronautical Society ; Number: AAS-05-374 SP - 1911 EP - 1928 PB - Univelt CY - San Diego, Calif. ER - TY - JOUR A1 - Dachwald, Bernd T1 - Low-Thrust Trajectory Optimization and Interplanetary Mission Analysis Using Evolutionary Neurocontrol JF - Deutscher Luft- und Raumfahrtkongress 2004 : Dresden, 20. bis 23. September 2004, Motto: Luft- und Raumfahrt - Brücke für eine wissensbasierte Gesellschaft / Deutsche Gesellschaft für Luft- und Raumfahrt - Lilienthal-Oberth e.V. (DGLR). [Red.: Peter Brandt (verantwortlich)]. - Bd. 2. - (Jahrbuch ... der Deutschen Gesellschaft für Luft- und Raumfahrt) Y1 - 2004 N1 - Deutscher Luft- und Raumfahrt-Kongress <2004, Dresden> ; Deutsche Gesellschaft für Luft- und Raumfahrt - Lilienthal-Oberth ; DGLR-2004-116 SP - 917 EP - 926 CY - Bonn ER - TY - JOUR A1 - Karamanidis, Kiros A1 - Albracht, Kirsten A1 - Braunstein, Bjoern A1 - Catala, Maria Moreno A1 - Goldmann, Jan-Peter A1 - Brüggemann, Gert-Peter T1 - Lower leg musculoskeletal geometry and sprint performance JF - Gait and Posture N2 - The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components. Y1 - 2011 U6 - http://dx.doi.org/10.1016/j.gaitpost.2011.03.009 SN - 0966-6362 VL - 34 IS - 1 SP - 138 EP - 141 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Eijck, Lambert van A1 - Demmel, Franz A1 - Artmann, Gerhard A1 - Stadtler, Andreas Maximilian T1 - Macromolecular dynamics in red blood cells investigated using neutron spectroscopy JF - Journal of the Royal Society Interface Y1 - 2011 SN - 1742-5689 VL - 8 IS - 57 SP - 590 EP - 600 PB - The Royal Society CY - London ER - TY - JOUR A1 - Dachwald, Bernd A1 - Seboldt, W. A1 - Loeb, H. W A1 - Schartner, K.-H. T1 - Main Belt Asteroid Sample Return Mission Using Solar Electric Propulsion JF - Acta Astronautica. 63 (2008), H. 1-4 Y1 - 2008 SN - 0094-5765 N1 - International Astronautical Federation Congress <58, 2007, Hyderabad> ; International Astronautical Congress <58, 2007, Hyderabad> ; IAC-07-A3.5.07 SP - 91 EP - 101 ER - TY - JOUR A1 - Seifarth, Volker A1 - Grosse, Joachim O. A1 - Grossmann, Matthias A1 - Janke, Heinz Peter A1 - Arndt, Patrick A1 - Koch, Sabine A1 - Epple, Matthias A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation JF - Journal of Biomaterials Applications Y1 - 2017 U6 - http://dx.doi.org/10.1177/0885328217723178 SN - 1530-8022 VL - 32 IS - 3 SP - 321 EP - 330 PB - Sage CY - London ER - TY - JOUR A1 - Chloé, Radermacher A1 - Malyaran, Hanna A1 - Craveiro, Rogerio Bastos A1 - Peglow, Sarah A1 - Behbahani, Mehdi A1 - Pufe, Thomas A1 - Wolf, Michael A1 - Neuss, Sabine T1 - Mechanical loading on cementoblasts: a mini review JF - Osteologie N2 - Orthodontic treatments are concomitant with mechanical forces and thereby cause teeth movements. The applied forces are transmitted to the tooth root and the periodontal ligaments which is compressed on one side and tensed up on the other side. Indeed, strong forces can lead to tooth root resorption and the crown-to-tooth ratio is reduced with the potential for significant clinical impact. The cementum, which covers the tooth root, is a thin mineralized tissue of the periodontium that connects the periodontal ligament with the tooth and is build up by cementoblasts. The impact of tension and compression on these cells is investigated in several in vivo and in vitro studies demonstrating differences in protein expression and signaling pathways. In summary, osteogenic marker changes indicate that cyclic tensile forces support whereas static tension inhibits cementogenesis. Furthermore, cementogenesis experiences the same protein expression changes in static conditions as static tension, but cyclic compression leads to the exact opposite of cyclic tension. Consistent with marker expression changes, the singaling pathways of Wnt/ß-catenin and RANKL/OPG show that tissue compression leads to cementum degradation and tension forces to cementogenesis. However, the cementum, and in particular its cementoblasts, remain a research area which should be explored in more detail to understand the underlying mechanism of bone resorption and remodeling after orthodontic treatments. KW - Cementoblast KW - Compression KW - Tension KW - Mechanotransduction KW - Forces Y1 - 2022 U6 - http://dx.doi.org/10.1055/a-1826-0777 SN - 1019-1291 VL - 31 IS - 2 SP - 111 EP - 118 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Demirci, T. A1 - Trzewik, J. A1 - Linder, Peter A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level JF - Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2 Y1 - 2004 SN - 0932-4666 SP - 1030 EP - 1031 ER - TY - JOUR A1 - Demirci, T. A1 - Trzewik, J. A1 - Linder, Peter A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison JF - Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2 Y1 - 2004 SN - 0932-4666 SP - 1046 EP - 1047 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Linder, Peter A1 - Porst, Dariusz T1 - Mechanism of haemoglobin sensing body temperature JF - Tissue Engineering Part A. 14 (2008), H. 5 Y1 - 2008 SN - 1937-3341 N1 - TERMIS EU 2008 Porto Meeting June 22–26, 2008 Porto Congress Center–Alfândega Portugal SP - 754 EP - 754 ER - TY - JOUR A1 - Goßmann, Matthias A1 - Frotscher, Ralf A1 - Linder, Peter A1 - Bayer, Robin A1 - Epple, U. A1 - Staat, Manfred A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells JF - Cellular physiology and biochemistry N2 - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential. KW - Inotropic compounds KW - Pharmacology KW - Ion channels KW - CellDrum KW - Heart tissue culture KW - Induced pluripotent stem cells KW - Cardiac myocytes Y1 - 2016 U6 - http://dx.doi.org/10.1159/000443124 SN - 1421-9778 (Online) SN - 1015-8987 (Print) VL - 38 IS - 3 SP - 1182 EP - 1198 PB - Karger CY - Basel ER - TY - JOUR A1 - Bayer, Robin A1 - Temiz Artmann, Aysegül A1 - Digel, Ilya A1 - Falkenstein, Julia A1 - Artmann, Gerhard A1 - Creutz, Till A1 - Hescheler, Jürgen T1 - Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model JF - Cellular Physiology and Biochemistry N2 - Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5% and 50nM verapamil by 2,8%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis. Y1 - 2020 U6 - http://dx.doi.org/10.33594/000000225 SN - 1421-9778 VL - 54 SP - 371 EP - 383 PB - Cell Physiol Biochem Press CY - Düsseldorf ER - TY - JOUR A1 - Becker, C. A1 - Wallang, C. A1 - Artmann, Gerhard A1 - Jakse, G. T1 - Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis JF - International Journal of Artificial Organs, The Y1 - 2008 SN - 0391-3988 N1 - Abstracts from the XXXV Congress of the European Society for Artificial Organs: 'Towards Future Biomedical Technologies' - ORAL PRESENTATIONS VL - 31 IS - 7 SP - 583 EP - 583 ER - TY - JOUR A1 - Werkhausen, Amelie A1 - Willwacher, Steffen A1 - Albracht, Kirsten T1 - Medial gastrocnemius muscle fascicles shorten throughout stance during sprint acceleration JF - Scandinavian Journal of Medicine & Science in Sports N2 - The compliant nature of distal limb muscle-tendon units is traditionally considered suboptimal in explosive movements when positive joint work is required. However, during accelerative running, ankle joint net mechanical work is positive. Therefore, this study aims to investigate how plantar flexor muscle-tendon behavior is modulated during fast accelerations. Eleven female sprinters performed maximum sprint accelerations from starting blocks, while gastrocnemius muscle fascicle lengths were estimated using ultrasonography. We combined motion analysis and ground reaction force measurements to assess lower limb joint kinematics and kinetics, and to estimate gastrocnemius muscle-tendon unit length during the first two acceleration steps. Outcome variables were resampled to the stance phase and averaged across three to five trials. Relevant scalars were extracted and analyzed using one-sample and two-sample t-tests, and vector trajectories were compared using statistical parametric mapping. We found that an uncoupling of muscle fascicle behavior from muscle-tendon unit behavior is effectively used to produce net positive mechanical work at the joint during maximum sprint acceleration. Muscle fascicles shortened throughout the first and second steps, while shortening occurred earlier during the first step, where negative joint work was lower compared with the second step. Elastic strain energy may be stored during dorsiflexion after touchdown since fascicles did not lengthen at the same time to dissipate energy. Thus, net positive work generation is accommodated by the reuse of elastic strain energy along with positive gastrocnemius fascicle work. Our results show a mechanism of how muscles with high in-series compliance can contribute to net positive joint work. KW - locomotion KW - muscle mechanics KW - running KW - sprint start KW - ultrasonography Y1 - 2021 U6 - http://dx.doi.org/10.1111/sms.13956 SN - 0905-7188 (Druckausgabe) SN - 1600-0838 (Onlineausgabe) VL - 31 IS - 7 SP - 1471 EP - 1480 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Martin-Gonzalez, Anabel A1 - Kotliar, Konstantin A1 - Rios-Martinez, Jorge A1 - Lanzl, Ines A1 - Navab, Nassir T1 - Mediated-reality magnification for macular degeneration rehabilitation JF - Journal of Modern Optics Y1 - 2014 U6 - http://dx.doi.org/10.1080/09500340.2014.936110 SN - 1362-3044 VL - 61 IS - 17 SP - 1400 EP - 1408 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Finocchiaro, Thomas A1 - Heinke, Stefanie A1 - Leßmann, Marc T1 - Methods of design, simulation, and control for the development of new VAD/TAH concepts = Methoden zur Konstruktion, Simulation und Regelung für die Entwicklung von neuen VAD/TAH-Konzepten / Finocchiaro, Thomas ; Heinke, Stefanie ; Behbahani, Mehdi ; Leßma JF - Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5 Y1 - 2009 SN - 0013-5585 N1 - Printausgabe in der Bereichsbibliothek Jülich vorhanden : 63 Z 471 SP - 269 EP - 281 ER - TY - JOUR A1 - Campen, R. A1 - Kowalski, Julia A1 - Lyons, W.B. A1 - Tulaczyk, S. A1 - Dachwald, Bernd A1 - Pettit, E. A1 - Welch, K. A. A1 - Mikucki, J.A. T1 - Microbial diversity of an Antarctic subglacial community and high‐resolution replicate sampling inform hydrological connectivity in a polar desert JF - Environmental Microbiology Y1 - 2019 U6 - http://dx.doi.org/10.1111/1462-2920.14607 SN - 1462-2920 IS - accepted article PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Nagel, Edgar A1 - Vilser, Walthard A1 - Seidova, Seid-Fatima A1 - Lanzl, Ines T1 - Microstructural alterations of retinal arterial blood column along the vessel axis in systemic hypertension JF - Investigative Ophthalmology & Visual Science, IOVS N2 - Purpose: Image analysis by the retinal vessel analyzer (RVA) observes retinal vessels in their dynamic state online noninvasively along a chosen vessel segment. It has been found that high-frequency diameter changes in the retinal artery blood column along the vessel increase significantly in anamnestically healthy volunteers with increasing age and in patients with glaucoma during vascular dilation. This study was undertaken to investigate whether longitudinal sections of the retinal artery blood column are altered in systemic hypertension. Methods: Retinal arteries of 15 untreated patients with essential arterial hypertension (age, 50.9 ± 11.9 years) and of 15 age-matched anamnestically healthy volunteers were examined by RVA. After baseline assessment, a monochromatic luminance flicker (530–600 nm; 12.5 Hz; 20 s) was applied to evoke retinal vasodilation. Differences in amplitude and frequency of spatial artery blood column diameter change along segments (longitudinal arterial profiles) of 1 mm in length were measured and analyzed using Fourier transformation. Results: In the control group, average reduced power spectra (ARPS) of longitudinal arterial profiles did not differ when arteries changed from constriction to dilation. In the systemic hypertension group, ARPS during constriction, baseline, and restoration were identical and differed from ARPS during dilation (P < 0.05). Longitudinal arterial profiles in both groups showed significant dissimilitude at baseline and restoration (P < 0.05). Conclusions: The retinal artery blood column demonstrates microstructural alterations in systemic hypertension and is less irregular along the vessel axis during vessel dilation. These microstructural changes may be an indication of alterations in vessel wall rigidity, vascular endothelial function, and smooth muscle cells in this disease, leading to impaired perfusion and regulation. Y1 - 2010 U6 - http://dx.doi.org/10.1167/iovs.09-3649 SN - 0146-0404 VL - 51 IS - 4 SP - 2165 EP - 2172 PB - ARVO CY - Rockville, Md. ER - TY - JOUR A1 - Steinseifer, Ulrich A1 - Kashefi, Ali A1 - Hormes, Marcus A1 - Schoberer, Mark A1 - Orlikowsky, Thorsten A1 - Behbahani, Mehdi A1 - Behr, Marek A1 - Schmitz-Rode, Thomas T1 - Miniaturization of ECMO Systems : Engineering Challenges and Methods JF - Artificial Organs. 33 (2009), H. 5 Y1 - 2009 SN - 1525-1594 N1 - Fifth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion Abstracts SP - A55 EP - A55 ER -