TY  - JOUR
A1  - Schuba, Marko
A1  - Reichl, Peter
T1  - How to Place Connectionless Servers in ATM Networks / Schuba, Marko ; Reichl, Peter
JF  - Proc. of Fourth IFIP Workshop on Performance Modelling and Evaluation of ATM Networks
Y1  - 1996
N1  - Fourth IFIP Workshop on Performance Modelling and Evaluation of ATM Networks, Ilkley, West Yorkshire, U.K., July 1996
SP  - 09/1
EP  - 09/10
ER  - 
TY  - CHAP
A1  - Becker, Jörg
A1  - Eggert, Mathias
A1  - Fleischer, Stefan
A1  - Knackstedt, Ralf
T1  - How to Teach Regulatory Compliant Data Warehouse Engineering?
T2  - Proceedings of the Nineteenth Americas Conference on Information Systems, Chicago, Illinois, August 15-17, 2013.
Y1  - 2013
N1  - AMCIS 2013 Proceedings
ER  - 
TY  - JOUR
A1  - Richter, Charlotte
A1  - Braunstein, Bjoern
A1  - Winnard, Andrew
A1  - Nasser, Mona
A1  - Weber, T.
T1  - Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review
JF  - Frontiers in physiology
Y1  - 2017
U6  - https://doi.org/10.3389/fphys.2017.00583
IS  - 8, article 583
ER  - 
TY  - JOUR
A1  - Ross, Jillian
A1  - Plummer, Simon M.
A1  - Rode, Anja
A1  - Scheer, Nico
A1  - Bower, Conrad C.
A1  - Vogel, Ortwin
A1  - Henderson, Colin J.
A1  - Wolf, C. Roland
A1  - Elcombe, Clifford R.
T1  - Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the  hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo
JF  - Toxicological Sciences
N2  - Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel “humanized” and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained.
Y1  - 2010
U6  - https://doi.org/10.1093/toxsci/kfq118
SN  - 1096-0929
VL  - 116
IS  - 2
SP  - 452
EP  - 466
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Mertens, Alexander
A1  - Pütz, Sebastian
A1  - Brauner, Philipp
A1  - Brillowski, Florian Sascha
A1  - Buczak, Nadine
A1  - Dammers, Hannah
A1  - van Dyck, Marc
A1  - Kong, Iris
A1  - Königs, Peter
A1  - Kortomeikel, Frauke Carole
A1  - Rodemann, Niklas
A1  - Schaar, Anne Kathrin
A1  - Steuer-Dankert, Linda
A1  - Wlecke, Shari
A1  - Gries, Thomas
A1  - Leicht-Scholten, Carmen
A1  - Nagel, Saskia K.
A1  - Piller, Frank Thomas
A1  - Schuh, Günther
A1  - Ziefle, Martina
A1  - Nitsch, Verena
T1  - Human digital shadow: Data-based modeling of users and usage in the internet of production
T2  - 14th Conference Human System Interaction Conference Proceedings
N2  - Digital Shadows as the aggregation, linkage and abstraction of data relating to physical objects are a central vision for the future of production. However, the majority of current research takes a technocentric approach, in which the human actors in production play a minor role. Here, the authors present an alternative anthropocentric perspective that highlights the potential and main challenges of extending the concept of Digital Shadows to humans. Following future research methodology, three prospections that illustrate use cases for Human Digital Shadows across organizational and hierarchical levels are developed: human-robot collaboration for manual work, decision support and work organization, as well as human resource management. Potentials and challenges are identified using separate SWOT analyses for the three prospections and common themes are emphasized in a concluding discussion.
KW  - digital shadow
KW  - cyber physical production system
KW  - user & usage
KW  - internet of production
Y1  - 2021
U6  - https://doi.org/10.1109/HSI52170.2021.9538729
N1  - 14th International Conference on Human System Interaction : 8-10 July 2021. Gdańsk, Poland
SP  - 1
EP  - 8
PB  - IEEE
ER  - 
TY  - JOUR
A1  - Whitehead, Mark
A1  - Öhlschläger, Peter
A1  - Almajhdi, Fahad N.
A1  - Alloza, Leonor
A1  - Marzábal, Pablo
A1  - Meyers, Ann E.
A1  - Hitzeroth, Inga I.
A1  - Rybicki, Edward P.
T1  - Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice
JF  - BMC cancer
Y1  - 2014
U6  - https://doi.org/10.1186/1471-2407-14-367
SN  - 1471-2407
IS  - 14:367
SP  - 1
EP  - 15
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Osen, Wolfram
A1  - Dell, Kerstin
A1  - Faath, Stefan
T1  - Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice / Öhlschläger, Peter ; Osen, Wolfram ; Dell, Kerstin ; Faath, Stefan ; Garcea Robert L: ; Jochmus, Ingrid ; Müller, Martin, Pawlita,
JF  - Journal of Virology. 77 (2003), H. 8
Y1  - 2003
SN  - 1098-5514
SP  - 4635
EP  - 4645
ER  - 
TY  - JOUR
A1  - Danho, Waleed
A1  - Naithani, Vinod K.
A1  - Sasaki, André N.
A1  - Föhles, Joseph
A1  - Berndt, Heinz
A1  - Büllesbach, Erika E.
A1  - Zahn, H.
T1  - Human proinsulin, VII : synthesis of two protected peptides corresponding to the sequences 1—45 and 46—86 of the prohormone
JF  - Hoppe-Seyler's Zeitschrift für physiologische Chemie
Y1  - 1980
U6  - https://doi.org/10.1515/bchm2.1980.361.1.857
SN  - 1437-4315
SN  - 0018-4888
VL  - 361
IS  - 1
SP  - 857
EP  - 863
ER  - 
TY  - JOUR
A1  - Ulmer, Jessica
A1  - Braun, Sebastian
A1  - Cheng, Chi-Tsun
A1  - Dowey, Steve
A1  - Wollert, Jörg
T1  - Human-Centered Gamification Framework for Manufacturing Systems
JF  - Procedia CIRP
N2  - While bringing new opportunities, the Industry 4.0 movement also imposes new challenges to the manufacturing industry and all its stakeholders. In this competitive environment, a skilled and engaged workforce is a key to success. Gamification can generate valuable feedbacks for improving employees’ engagement and performance. Currently, Gamification in workspaces focuses on computer-based assignments and training, while tasks that require manual labor are rarely considered. This research provides an overview of Enterprise Gamification approaches and evaluates the challenges. Based on that, a skill-based Gamification framework for manual tasks is proposed, and a case study in the Industry 4.0 model factory is shown.
Y1  - 2020
U6  - https://doi.org/10.1016/j.procir.2020.04.076
SN  - 2212-8271
VL  - 93
SP  - 670
EP  - 675
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Baier, Ralph
A1  - Brauner, Philipp
A1  - Brillowski, Florian
A1  - Dammers, Hannah
A1  - Liehner, Luca
A1  - Pütz, Sebastian
A1  - Schneider, Sebastian
A1  - Schollemann, Alexander
A1  - Steuer-Dankert, Linda
A1  - Vervier, Luisa
A1  - Gries, Thomas
A1  - Leicht-Scholten, Carmen
A1  - Mertens, Alexander
A1  - Nagel, Saskia K.
A1  - Schuh, Günther
A1  - Ziefle, Martina
A1  - Nitsch, Verena
ED  - Brecher, Christian
ED  - Schuh, Günther
ED  - van der Alst, Wil
ED  - Jarke, Matthias
ED  - Piller, Frank T.
ED  - Padberg, Melanie
T1  - Human-centered work design for the internet of production
T2  - Internet of production - fundamentals, applications and proceedings
N2  - Like all preceding transformations of the manufacturing industry, the large-scale usage of production data will reshape the role of humans within the sociotechnical production ecosystem. To ensure that this transformation creates work systems in which employees are empowered, productive, healthy, and motivated, the transformation must be guided by principles of and research on human-centered work design. Specifically, measures must be taken at all levels of work design, ranging from (1) the work tasks to (2) the working conditions to (3) the organizational level and (4) the supra-organizational level. We present selected research across all four levels that showcase the opportunities and requirements that surface when striving for human-centered work design for the Internet of Production (IoP). (1) On the work task level, we illustrate the user-centered design of human-robot collaboration (HRC) and process planning in the composite industry as well as user-centered design factors for cognitive assistance systems. (2) On the working conditions level, we present a newly developed framework for the classification of HRC workplaces. (3) Moving to the organizational level, we show how corporate data can be used to facilitate best practice sharing in production networks, and we discuss the implications of the IoP for new leadership models. Finally, (4) on the supra-organizational level, we examine overarching ethical dimensions, investigating, e.g., how the new work contexts affect our understanding of responsibility and normative values such as autonomy and privacy. Overall, these interdisciplinary research perspectives highlight the importance and necessary scope of considering the human factor in the IoP.
KW  - Responsibility
KW  - Privacy
KW  - Digital leadership
KW  - Best practice sharing
KW  - Cognitive assistance system
KW  - Human-robot collaboration
KW  - Human-centered work design
Y1  - 2023
SN  - 978-3-030-98062-7
U6  - https://doi.org/10.1007/978-3-030-98062-7_19-1
N1  - Part of the book series: Interdisciplinary Excellence Accelerator Series (IDEAS)
SP  - 1
EP  - 23
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Kazuki, Yasuhiro
A1  - Kobayashi, Kaoru
A1  - Hirabayashi, Masumi
A1  - Abe, Satoshi
A1  - Kajitani, Naoyo
A1  - Kazuki, Kanoko
A1  - Takehara, Shoko
A1  - Takiguchi, Masato
A1  - Satoh, Daisuke
A1  - Kuze, Jiro
A1  - Sakuma, Tetsushi
A1  - Kaneko, Takehito
A1  - Mashimo, Tomoji
A1  - Osamura, Minori
A1  - Hashimoto, Mari
A1  - Wakatsuki, Riko
A1  - Hirashima, Rika
A1  - Fujiwara, Ryoichi
A1  - Deguchi, Tsuneo
A1  - Kurihara, Atsushi
A1  - Tsukazaki, Yasuko
A1  - Senda, Naoto
A1  - Yamamoto, Takashi
A1  - Scheer, Nico
A1  - Oshimura, Mitsuo
T1  - Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
T2  - PNAS Proceedings of the National Academy of Sciences of the United States of America
Y1  - 2019
U6  - https://doi.org/10.1073/pnas.1808255116
SN  - 1091-6490
VL  - 116
IS  - 8
SP  - 3072
EP  - 3081
ER  - 
TY  - BOOK
A1  - Ferrein, Alexander
A1  - Pauli, J.
A1  - Siebel, N. T.
A1  - Steinbauer, Gerald
T1  - Hybrid control for autonomous systems : [... 1st Workshop on Hybrid Control of Autonomous Systems - Integrating Learning, Deliberation and Reactive Control with the 21st International Joint Conference on Artificial Intelligence (IJCAI-09), held in Pasadena, CA, in July 2009] / ed. by Alexander Ferrein ...
Y1  - 2009
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Siebel, Nils T.
A1  - Steinbauer, Gerald
T1  - Hybrid control for autonomous systems — Integrating learning, deliberation and reactive control
JF  - Robotics and Autonomous Systems
Y1  - 2010
SN  - 0921-8890
VL  - 58
IS  - 9
SP  - 1037
EP  - 1038
ER  - 
TY  - CHAP
A1  - Valero, Daniel
A1  - Bung, Daniel Bernhard
T1  - Hybrid investigation of air transport processes in moderately sloped stepped spillway flows
T2  - E-proceedings of the 36th IAHR World Congress 28 June – 3 July, 2015, The Hague, the Netherlands
Y1  - 2015
SP  - 1
EP  - 10
ER  - 
TY  - CHAP
A1  - Langohr, Philipp
A1  - Bung, Daniel Bernhard
A1  - Crookston, Brian M.
ED  - Ortega-Sánchez, Miguel
T1  - Hybrid investigation of labyrinth weirs: Discharge capacity and energy dissipation
T2  - Proceedings of the 39th IAHR World Congress
N2  - The replacement of existing spillway crests or gates with labyrinth weirs is a proven techno-economical means to increase the discharge capacity when rehabilitating existing structures. However, additional information is needed regarding energy dissipation of such weirs, since due to the folded weir crest, a three-dimensional flow field is generated, yielding more complex overflow and energy dissipation processes. In this study, CFD simulations of labyrinth weirs were conducted 1) to analyze the discharge coefficients for different discharges to compare the Cd values to literature data and 2) to analyze and improve energy dissipation downstream of the structure. All tests were performed for a structure at laboratory scale with a height of approx. P = 30.5 cm, a ratio of the total crest length to the total width of 4.7, a sidewall angle of 10° and a quarter-round weir crest shape. Tested headwater ratios were 0.089 ≤ HT/P ≤ 0.817. For numerical simulations, FLOW-3D Hydro was employed, solving the RANS equations with use of finite-volume method and RNG k-ε turbulence closure. In terms of discharge capacity, results were compared to data from physical model tests performed at the Utah Water Research Laboratory (Utah State University), emphasizing higher discharge coefficients from CFD than from the physical model. For upstream heads, some discrepancy in the range of ± 1 cm between literature, CFD and physical model tests was identified with a discussion regarding differences included in the manuscript. For downstream energy dissipation, variable tailwater depths were considered to analyze the formation and sweep-out of a hydraulic jump. It was found that even for high discharges, relatively low downstream Froude numbers were obtained due to high energy dissipation involved by the three-dimensional flow between the sidewalls. The effects of some additional energy dissipation devices, e.g. baffle blocks or end sills, were also analyzed. End sills were found to be non-effective. However, baffle blocks with different locations may improve energy dissipation downstream of labyrinth weirs.
Y1  - 2022
SN  - 978-90-832612-1-8
U6  - https://doi.org/10.3850/IAHR-39WC252171192022738
SN  - 2521-7119 (print)
SN  - 2521-716X (online)
N1  - 39th IAHR World Congress, 19. - 24. Juni 2022, Granada
SP  - 2313
EP  - 2318
PB  - International Association for Hydro-Environment Engineering and Research (IAHR)
CY  - Madrid
ER  - 
TY  - CHAP
A1  - Pak, Daniel
A1  - Piegeler, D.
A1  - Feldmann, Markus
A1  - Schleser, Markus
A1  - Dilthey, Ulrich
ED  - Hegger, Josef
T1  - Hybrid joints of textile reinforced concrete parts - designed for assembly
T2  - Textile reinforced concrete : proceedings of the 1. International RILEM Conference, held at the RWTH Aachen, September 6/7, 2006. (RILEM proceedings ; 50)
Y1  - 2006
SN  - 2-912143-97-7
SP  - 181
EP  - 190
PB  - RILEM Publ.
CY  - Bagneux
ER  - 
TY  - JOUR
A1  - Morais, Paulo V.
A1  - Silva, Anielle C. A.
A1  - Dantas, Noelio O.
A1  - Schöning, Michael Josef
A1  - Siqueira, José R., Jr.
T1  - Hybrid Layer‐by‐Layer Film of Polyelectrolytes‐Embedded Catalytic CoFe2O4 Nanocrystals as Sensing Units in Capacitive Electrolyte‐Insulator‐Semiconductor Devices
JF  - physica status solidi a : applications and materials sciences
Y1  - 2019
U6  - https://doi.org/10.1002/pssa.201900044
VL  - 216
IS  - 1900044
SP  - 1
EP  - 9
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Förster, Arnold
A1  - Lachenmann, S. G.
A1  - Kastalsky, A.
A1  - Uhlisch, D.
T1  - Hybrid superconductor/semiconductor step junction with three terminals. Lachenmann, S. G.; Kastalsky, A.; Förster A.; Uhlisch, D.; Neurohr, K.; Schäpers, Th.
JF  - Journal of Applied Physics. 83 (1998), H. 12
Y1  - 1998
SN  - 1089-7550
SP  - 8077
EP  - 8079
ER  - 
TY  - JOUR
A1  - Hagemann, Hans-Jürgen
A1  - Geittner, P.
A1  - Lydtin, H.
A1  - Warnier, J.
T1  - Hybrid technology for large SM-fiber preforms. Geittner, P.; Hagemann, H. J.; Lydtin, H.; Warnier, J.
JF  - Journal of Lightwave Technology (J-LT) / Institute of Electrical and Electronics Engineers (IEEE). 6 (1988), H. 10
Y1  - 1988
SN  - 0733-8724
SP  - 1451
EP  - 1454
ER  - 
TY  - CHAP
A1  - Bung, Daniel Bernhard
A1  - Tullis, Blake
T1  - Hydraulic Structures - ISHS2018 in Perspective
T2  - 7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May
Y1  - 2018
SN  - 978-0-692-13277-7
U6  - https://doi.org/10.15142/T3WH2B
ER  -