TY  - CHAP
A1  - Raman, Aravind Hariharan
A1  - Jung, Alexander
A1  - Horváth, András
A1  - Becker, Nadine
A1  - Staat, Manfred
ED  - Staat, Manfred
ED  - Erni, Daniel
T1  - Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements
T2  - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
N2  - Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - http://dx.doi.org/10.17185/duepublico/48750
SP  - 10
EP  - 11
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Slabu, Ioana
A1  - Roeth, Anjali A.
A1  - Engelmann, Ulrich M.
A1  - Wiekhorst, Frank
A1  - Buhl, Eva M.
A1  - Neumann, Ulf P.
A1  - Schmitz-Rode, Thomas
T1  - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro
JF  - Nanotechnology
Y1  - 2019
U6  - http://dx.doi.org/10.1088/1361-6528/ab033e
SN  - 1361-6528
VL  - 30
IS  - 18
SP  - 184004
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
T1  - Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue
JF  - GAMM - Mitteilungen der Gesellschaft für Angewandte Mathematik und Mechanik
Y1  - 2019
U6  - http://dx.doi.org/10.1002/gamm.201900002
SN  - 1522-2608
VL  - 42
IS  - 4
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Braun, Sebastian
A1  - Cheng, Chi-Tsun
A1  - Lai, Chow Yin
A1  - Wollert, Jörg
T1  - Microservice Architecture for Automation - Realization by the example of a model-factory’s manufacturing execution system
T2  - Proceedings of the 23rd World Multi-Conference on Systemics, Cybernetics and Informatics: WMSCI 2019
Y1  - 2019
SP  - 33
EP  - 37
ER  - 
TY  - JOUR
A1  - Campen, R.
A1  - Kowalski, Julia
A1  - Lyons, W.B.
A1  - Tulaczyk, S.
A1  - Dachwald, Bernd
A1  - Pettit, E.
A1  - Welch, K. A.
A1  - Mikucki, J.A.
T1  - Microbial diversity of an Antarctic subglacial community and high‐resolution replicate sampling inform hydrological connectivity in a polar desert
JF  - Environmental Microbiology
Y1  - 2019
U6  - http://dx.doi.org/10.1111/1462-2920.14607
SN  - 1462-2920
IS  - accepted article
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Schildt, Ph.
A1  - Braun, Carsten
A1  - Marzocca, P.
T1  - Metric evaluating potentials of condition-monitoring approaches for hybrid electric aircraft propulsion systems
JF  - CEAS Aeronautical Journal
Y1  - 2019
U6  - http://dx.doi.org/10.1007/s13272-019-00411-3
SN  - 1869-5590
SP  - 1
EP  - 14
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Scholl, Ingrid
A1  - Bartella, Alex
A1  - Moluluo, Cem
A1  - Ertural, Berat
A1  - Laing, Frederic
A1  - Suder, Sebastian
T1  - MedicVR : Acceleration and Enhancement Techniques for Direct Volume Rendering in Virtual Reality
T2  - Bildverarbeitung für die Medizin 2019 : Algorithmen – Systeme – Anwendungen
Y1  - 2019
SN  - 978-3-658-25326-4
U6  - http://dx.doi.org/10.1007/978-3-658-25326-4_32
SP  - 152
EP  - 157
PB  - Springer Vieweg
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Achtsnicht, Stefan
A1  - Schönenborn, Kristina
A1  - Offenhäusser, Andreas
A1  - Krause, Hans-Joachim
T1  - Measurement of the magnetophoretic velocity of different superparamagnetic beads
JF  - Journal of Magnetism and Magnetic Materials
N2  - The movement of magnetic beads due to a magnetic field gradient is of great interest in different application fields. In this report we present a technique based on a magnetic tweezers setup to measure the velocity factor of magnetically actuated individual superparamagnetic beads in a fluidic environment. Several beads can be tracked simultaneously in order to gain and improve statistics. Furthermore we show our results for different beads with hydrodynamic diameters between 200 and 1000 nm from diverse manufacturers. These measurement data can, for example, be used to determine design parameters for a magnetic separation system, like maximum flow rate and minimum separation time, or to select suitable beads for fixed experimental requirements.
KW  - magnetophoretic velocity
KW  - superparamagnetic bead
KW  - magnetic tweezers
KW  - magnetic separation
KW  - magnetic actuation
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.jmmm.2018.10.066
SN  - 0304-8853
VL  - 477
IS  - 1
SP  - 244
EP  - 248
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - BOOK
A1  - Budelmann, Harald
A1  - Butenweg, Christoph
ED  - Gunkler, Erhard
T1  - Mauerwerksbau: Bemessung und Konstruktion : Baustoffe, Bemessung und Ausführung, Brandschutz und Erdbeben, Nachhaltigkeit, Bewertung und Revitalisierung
Y1  - 2019
SN  - 978-3-8462-0371-2
N1  - gedruckt in der Bereichsbibliothek Bayernallee vorhanden
PB  - Bundesanzeiger Verlag
CY  - Köln
ET  - 2. überarbeitete und aktualisierte Auflage
ER  - 
TY  - CHAP
A1  - Eschler, Eric
A1  - Wozniak, Felix
A1  - Richter, Christoph
A1  - Drechsler, Klaus
T1  - Materialanalyse an lokal verstärkten Triaxialgeflechten
T2  - Leichtbau in Forschung und industrieller Anwendung von der Nano- bis zur Makroebene, LLC, Landshuter Leichtbau-Colloquium, 9
Y1  - 2019
SN  - 978-3-9818439-2-7
SP  - 120
EP  - 131
PB  - Leichtbau Cluster
CY  - Landshut
ER  - 
TY  - CHAP
A1  - Finger, Felix
A1  - Götten, Falk
A1  - Braun, Carsten
A1  - Bil, Cees
T1  - Mass, Primary Energy, and Cost - The Impact of Optimization Objectives on the Initial Sizing of Hybrid-Electric General Aviation Aircraft
T2  - Deutscher Luft- und Raumfahrtkongress 2019, DLRK 2019. Darmstadt, Germany
Y1  - 2019
U6  - http://dx.doi.org/10.25967/490012
SP  - 1
EP  - 17
ER  - 
TY  - CHAP
A1  - Weber, Tobias
A1  - Englhard, Markus
A1  - Hailer, Benjamin
A1  - Arent, Jan-Christoph
T1  - Manufacturing Process Simulation for the Prediction of Tool-Part-Interaction and Ply Wrinkling
T2  - Proceedings of SAMPE Europe Conference 2019, Nantes, France
Y1  - 2019
SP  - 1
EP  - 10
ER  - 
TY  - CHAP
A1  - Hailer, Benjamin
A1  - Weber, Tobias
A1  - Arent, Jan-Christoph
T1  - Manufacturing Process Simulation for Autoclave-Produced Sandwich Structures
T2  - Proceedings of SAMPE Europe Conference 2019, Nantes, France
Y1  - 2019
SP  - 1
EP  - 8
ER  - 
TY  - CHAP
A1  - Stenger, David
A1  - Altherr, Lena
A1  - Abel, Dirk
T1  - Machine learning and metaheuristics for black-box optimization of product families: a case-study investigating solution quality vs. computational overhead
T2  - Operations Research Proceedings 2018
N2  - In product development, numerous design decisions have to be made. Multi-domain virtual prototyping provides a variety of tools to assess technical feasibility of design options, however often requires substantial computational effort for just a single evaluation. A special challenge is therefore the optimal design of product families, which consist of a group of products derived from a common platform. Finding an optimal platform configuration (stating what is shared and what is individually designed for each product) and an optimal design of all products simultaneously leads to a mixed-integer nonlinear black-box optimization model. We present an optimization approach based on metamodels and a metaheuristic. To increase computational efficiency and solution quality, we compare different types of Gaussian process regression metamodels adapted from the domain of machine learning, and combine them with a genetic algorithm. We illustrate our approach on the example of a product family of electrical drives, and investigate the trade-off between solution quality and computational overhead.
KW  - Product family optimization
KW  - Mixed-integer nonlinear black-box optimization
KW  - Engineering optimization
KW  - Machine learning
Y1  - 2019
SN  - 978-3-030-18499-5  (Print)
SN  - 978-3-030-18500-8 (Online)
U6  - http://dx.doi.org/10.1007/978-3-030-18500-8_47
SP  - 379
EP  - 385
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Tippkötter, Nils
A1  - Möhring, Sophie
A1  - Roth, Jasmine
A1  - Wulfhorst, Helene
T1  - Logistics of lignocellulosic feedstocks: preprocessing as a preferable option
T2  - Biorefineries
N2  - In comparison to crude oil, biorefinery raw materials are challenging in concerns of transport and storage. The plant raw materials are more voluminous, so that shredding and compacting usually are necessary before transport. These mechanical processes can have a negative influence on the subsequent biotechnological processing and shelf life of the raw materials. Various approaches and their effects on renewable raw materials are shown. In addition, aspects of decentralized pretreatment steps are discussed. Another important aspect of pretreatment is the varying composition of the raw materials depending on the growth conditions. This problem can be solved with advanced on-site spectrometric analysis of the material.
KW  - Analytics
KW  - Decentral
KW  - Mechanical
KW  - On-site
KW  - Pre-treatment
Y1  - 2019
SN  - 978-3-319-97117-9
SN  - 978-3-319-97119-3
U6  - http://dx.doi.org/10.1007/10_2017_58
N1  - Advances in biochemical engineering/biotechnology ; Vol. 166
SP  - 43
EP  - 68
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Roeth, A.A.
A1  - Slabu, I.
A1  - Kessler, A.
A1  - Engelmann, Ulrich M.
T1  - Local treatment of pancreatic cancer with magnetic nanoparticles
JF  - HPB
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.hpb.2019.10.959
SN  - 1365-182X
VL  - 21
IS  - Supplement 3
SP  - S868
EP  - S869
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - THES
A1  - Tran, Ngoc Trinh
T1  - Limit and Shakedown analysis of structures under stochastic conditions
Y1  - 2019
U6  - http://dx.doi.org/10.24355/dbbs.084-201902121135-0
PB  - Technische Universität Braunschweig
CY  - Braunschweig
ER  - 
TY  - JOUR
A1  - Meyer, Carolin
A1  - Gaalen, Kerstin van
A1  - Leschinger, Tim
A1  - Scheyerer, Max J.
A1  - Neiss, Wolfram F.
A1  - Staat, Manfred
A1  - Müller, Lars P.
A1  - Wegmann, Kilian
T1  - Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement
JF  - BioMed Research International
Y1  - 2019
U6  - http://dx.doi.org/10.1155/2019/9232813
SP  - Article ID 9232813
ER  - 
TY  - CHAP
A1  - Moll, Florian
A1  - Köhler, Klemens
A1  - Wolf, Martin
T1  - Konzeption von IT-Sicherheitslösungen unter ethischen Gesichtspunkten am Beispiel einer Monitoring-App für mobile Endgeräte
T2  - Angewandte Forschung in der Wirtschaftsinformatik 2019 : Tagungsband zur 32. AKWI-Jahrestagung
N2  - Die steigende Popularität von mobilen Endgeräten im privaten und geschäftlichen Umfeld geht mit einem Anstieg an Sicherheitslücken und somit potentiellen Angriffsflächen einher. Als ein Element der technischen und organisatorischen Maßnahmen zum Schutz eines Netzwerkes können Monitoring-Apps dienen, die unerwünschtes Verhalten und Angriffe erkennen. Die automatisierte Überwachung von Endgeräten ist jedoch rechtlich und ethisch komplex. Dies in Kombination mit einer hohen Sensibilität der Nutzer und Nutzerinnen dieser Geräte in Bezug auf Privatsphäre, kann zu einer geringen Akzeptanz und Compliance führen. Eine datenschutzrechtlich und ethisch einwandfreie Konzeption solcher Apps bereits im Designprozess führt zu höherer Akzeptanz und verbessert so die Effizienz. Diese Analyse beschreibt Möglichkeiten zur Umsetzung.
Y1  - 2019
SN  - 978-3-944330-62-4
SP  - 61
EP  - 72
PB  - mana-Buch
CY  - Heide
ER  - 
TY  - CHAP
A1  - Finkenberger, Isabel Maria
A1  - Baumeister, Eva-Maria
A1  - Koch, Christian
T1  - Komplement und Verstärker : Wandel durch neue Allianzen
T1  - Amplifier and complement : creating change through new alliances
T2  - Komplement und Verstärker : zum Verhältnis von Stadtplanung, künstlerischen Praktiken und Kulturinstitutionen
Y1  - 2019
SN  - 978-3-86859-578-9
SP  - 10
EP  - 39
PB  - JOVIS Verlag
CY  - Berlin
ER  -