TY  - JOUR
A1  - Honarvarfard, Elham
A1  - Gamella, Maria
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer
JF  - Applied Materials Today
N2  - An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte–insulator–semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
KW  - Electrolyte–insulator–semiconductor
KW  - Capacitive field-effect
KW  - CNOT
KW  - XOR
KW  - Enzyme logic gate
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.apmt.2017.08.003
SN  - 2352-9407
VL  - 9
SP  - 266
EP  - 270
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Röhlen, Desiree
A1  - Pilas, Johanna
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
T1  - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid
JF  - Applied Biochemistry and Biotechnology
N2  - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates.
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s12010-017-2578-1
SN  - 1559-0291
VL  - 183
SP  - 566
EP  - 581
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Yazici, Yasemen
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Optimization of an amperometric biosensor array for simultaneous measurement of ethanol, formate, d- and l-lactate
JF  - Electrochimica Acta
N2  - The immobilization of NAD+-dependent dehydrogenases, in combination with a diaphorase, enables the facile development of multiparametric sensing devices. In this work, an amperometric biosensor array for simultaneous determination of ethanol, formate, d- and l-lactate is presented. Enzyme immobilization on platinum thin-film electrodes was realized by chemical cross-linking with glutaraldehyde. The optimization of the sensor performance was investigated with regard to enzyme loading, glutaraldehyde concentration, pH, cofactor concentration and temperature. Under optimal working conditions (potassium phosphate buffer with pH 7.5, 2.5 mmol L-1 NAD+, 2.0 mmol L-1 ferricyanide, 25 °C and 0.4% glutaraldehyde) the linear working range and sensitivity of the four sensor elements was improved. Simultaneous and cross-talk free measurements of four different metabolic parameters were performed successfully. The reliable analytical performance of the biosensor array was demonstrated by application in a clarified sample of inoculum sludge. Thereby, a promising approach for on-site monitoring of fermentation processes is provided.
KW  - Simultaneous determination
KW  - Enzymatic biosensor
KW  - Diaphorase
KW  - Dehydrogenase
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.electacta.2017.07.119
SN  - 0013-4686
VL  - 251
SP  - 256
EP  - 262
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Lueke, Jan Niklas
A1  - Sjapic, Volha
A1  - Kotliar, Konstantin
A1  - Hescheler, Jürgen
A1  - Clusmann, Hans
A1  - Sjapic, Sergej
A1  - Alpdogan, Serdan
A1  - Schneider, Toni
A1  - Schubert, Gerrit Alexander
A1  - Neumaier, Felix
T1  - Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina
JF  - Current Eye Research
Y1  - 2017
U6  - http://dx.doi.org/10.1080/02713683.2017.1339807
SN  - 1460-2202
IS  - Article in press
SP  - 1
EP  - 9
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - CHAP
A1  - Breuer, Lars
A1  - Guthmann, Eric
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Light-Stimulated Hydrogels with Incorporated Graphene Oxide as Actuator Material for Flow Control in Microfluidic Applications
T2  - Proceedings Eurosensors 2017 Conference, Paris, France, 3–6 September 2017
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1040524
SP  - 1
EP  - 4
ER  - 
TY  - GEN
A1  - Hackl, Michael
A1  - Wegmann, Kilian
A1  - Kahmann, Stephanie Lucina
A1  - Heinze, Nicolai
A1  - Staat, Manfred
A1  - Neiss, Wolfram F.
A1  - Scaal, Martin
A1  - Müller, Lars P.
T1  - Reply to the letter to the editor: shortening osteotomy of the proximal radius
T2  - Knee Surgery, Sports Traumatology, Arthroscopy
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s00167-017-4666-8
VL  - 25
IS  - 10
SP  - 3328
EP  - 3329
ER  - 
TY  - CHAP
A1  - Jablonski, Melanie
A1  - Koch, Claudia
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Field-Effect Biosensors Modified with Tobacco Mosaic Virus Nanotubes as Enzyme Nanocarrier
T2  - MDPI Proceeding
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1040505
N1  - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017
VL  - 1
IS  - 4
ER  - 
TY  - CHAP
A1  - Miyamoto, Ko-ichiro
A1  - Suto, Takeyuki
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Restraining the Diffusion of Photocarriers to Improve the Spatial Resolution of the Chemical Imaging Sensor
T2  - MDPI Proceedings
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1040477
N1  - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017
VL  - 1
IS  - 4
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Hauser, Christine
A1  - Ortner, Marion
A1  - Muggenthaler, Claudia
A1  - Diehl-Schmid, Janine
A1  - Angermann, Susanne
A1  - Hapfelmeier, Alexander
A1  - Schmaderer, Christoph
A1  - Grimmer, Timo
T1  - Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
JF  - Scientific Reports
Y1  - 2017
U6  - http://dx.doi.org/10.1038/s41598-017-13349-5
SN  - 2045-2322
N1  - Article 12906
VL  - 7
IS  - 1
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Investigation of the spatial resolution of a laser-based stimulation process for light-addressable hydrogels with incorporated graphene oxide by means of IR thermography
JF  - Sensors and Actuators A: Physical
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.sna.2017.11.031
SN  - 0924-4247
VL  - 268
SP  - 126
EP  - 132
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Garibaldi, F.
A1  - Beging, Stefan
A1  - Canese, R.
A1  - Carpinelli, G.
A1  - Clinthorne, N.
A1  - Colilli, S.
A1  - Cosentino, L.
A1  - Finocchiaro, P.
A1  - Giuliani, F.
A1  - Gricia, M.
A1  - Lucentini, M.
A1  - Majewski, S.
A1  - Monno, E.
A1  - Musico, P.
A1  - Santavenere, F.
A1  - Tödter, J.
A1  - Wegener, Hans-Peter
A1  - Ziemons, Karl
T1  - A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer
JF  - European Physical Journal Plus
Y1  - 2017
U6  - http://dx.doi.org/10.1140/epjp/i2017-11662-x
SN  - 2190-5444
VL  - 132
IS  - 9
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Schmidts, Oliver
A1  - Boltes, Maik
A1  - Kraft, Bodo
A1  - Schreiber, Marc
T1  - Multi-pedestrian tracking by moving Bluetooth-LE beacons and stationary receivers
T2  - 2017 International Conference on Indoor Positioning and Indoor Navigation (IPIN), 18-21 September 2017, Sapporo, Japan
Y1  - 2017
N1  - International Conference on Indoor Positioning and Indoor Navigation <8, 2017, Sapporo, Japan>
SP  - 1
EP  - 4
ER  - 
TY  - JOUR
A1  - Bäcker, M.
A1  - Rakowski, D.
A1  - Krappen, E.
A1  - Schöning, Michael Josef
T1  - Reinigungsprozesse in der Lebensmittelindustrie. Entwicklung eines Demonstrators zur Überwachung
JF  - GIT Labor-Fachzeitschrift
Y1  - 2017
SN  - 0016-3538
VL  - 61
IS  - 8
SP  - 26
EP  - 28
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Dikta, Gerhard
T1  - Semi-parametric random censorship models
JF  - From Statistics to Mathematical Finance : Festschrift in Honour of Winfried Stute
Y1  - 2017
SN  - 978-3-319-50986-0
U6  - http://dx.doi.org/10.1007/978-3-319-50986-0_3
SP  - 43
EP  - 56
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Karnatak, Rajat
A1  - Kantz, Holger
A1  - Bialonski, Stephan
T1  - Early warning signal for interior crises in excitable systems
JF  - Physical Review E
Y1  - 2017
U6  - http://dx.doi.org/10.1103/PhysRevE.96.042211
SN  - 2470-0053
VL  - 96
IS  - 4
SP  - 042211
ER  - 
TY  - JOUR
A1  - Richter, Charlotte
A1  - Braunstein, Bjoern
A1  - Winnard, Andrew
A1  - Nasser, Mona
A1  - Weber, T.
T1  - Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review
JF  - Frontiers in physiology
Y1  - 2017
U6  - http://dx.doi.org/10.3389/fphys.2017.00583
IS  - 8, article 583
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Buhl, Eva Miriam
A1  - Baumann, Martin
A1  - Schmitz-Rode, Thomas
A1  - Slabu, Ioana
T1  - Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia
JF  - Current Directions in Biomedical Engineering
Y1  - 2017
U6  - http://dx.doi.org/10.1515/cdbme-2017-0096
SN  - 2364-5504
VL  - 3
IS  - 2
SP  - 457
EP  - 460
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Chen, Chao
A1  - Jost, Peter
A1  - Volker, Hanno
A1  - Kaminski, Marvin
A1  - Wirtssohn, Matti R.
A1  - Engelmann, Ulrich M.
A1  - Krüger, K.
A1  - Schlich, Franziska F.
A1  - Schlockermann, Carl
A1  - Lobo, Ricardo P.S.M.
A1  - Wuttig, Matthias
T1  - Dielectric properties of amorphous phase-change materials
JF  - Physical Review B
Y1  - 2017
U6  - http://dx.doi.org/10.1103/PhysRevB.95.094111
SN  - 2469-9950
VL  - 95
IS  - 9
SP  - Article number 094111
ER  - 
TY  - JOUR
A1  - Röth, A.A.
A1  - Slabu, I.
A1  - Engelmann, Ulrich M.
A1  - Baumann, M.
A1  - Schmitz-Rode, T.
A1  - Neumann, U. P.
T1  - Targeting von gastroenterologischen Tumoren mittels magnetischer Nanopartikel zur hyperthermischen Therapie
JF  - Zeitschrift für Gastroenterologie
Y1  - 2017
U6  - http://dx.doi.org/10.1055/s-0037-1605124
VL  - 55
IS  - 8
SP  - KV-384
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Savitskaya, I. S.
A1  - Kistaubayeva, A. S.
A1  - Digel, Ilya
A1  - Shokatayeva, D. H.
T1  - Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials
JF  - Eurasian Chemico-Technological Journal
Y1  - 2017
U6  - http://dx.doi.org/10.18321/ectj670
SN  - 2522-4867
VL  - 19
IS  - 3
SP  - 255
EP  - 264
ER  -