TY - JOUR A1 - Kotliar, Konstantin A1 - Hanssen, Henner A1 - Eberhardt, Karla A1 - Vilser, Walthard A1 - Schmaderer, Christoph A1 - Halle, Martin A1 - Heemann, Uwe A1 - Baumann, Marcus T1 - Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects JF - Microcirculation Y1 - 2013 SN - 1549-8719 N1 - Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) PB - Wiley CY - Malden ER - TY - JOUR A1 - Schmidt, Katharina A1 - Forkmann, Katarina A1 - Sinke, C. A1 - Gratz, Marcel A1 - Bitz, Andreas A1 - Bingel, Ulrike T1 - The differential effect of trigeminal vs. peripheral pain stimulation on visual processing and memory encoding is influenced by pain-related fear JF - NeuroImage N2 - Compared to peripheral pain, trigeminal pain elicits higher levels of fear, which is assumed to enhance the interruptive effects of pain on concomitant cognitive processes. In this fMRI study we examined the behavioral and neural effects of trigeminal (forehead) and peripheral (hand) pain on visual processing and memory encoding. Cerebral activity was measured in 23 healthy subjects performing a visual categorization task that was immediately followed by a surprise recognition task. During the categorization task subjects received concomitant noxious electrical stimulation on the forehead or hand. Our data show that fear ratings were significantly higher for trigeminal pain. Categorization and recognition performance did not differ between pictures that were presented with trigeminal and peripheral pain. However, object categorization in the presence of trigeminal pain was associated with stronger activity in task-relevant visual areas (lateral occipital complex, LOC), memory encoding areas (hippocampus and parahippocampus) and areas implicated in emotional processing (amygdala) compared to peripheral pain. Further, individual differences in neural activation between the trigeminal and the peripheral condition were positively related to differences in fear ratings between both conditions. Functional connectivity between amygdala and LOC was increased during trigeminal compared to peripheral painful stimulation. Fear-driven compensatory resource activation seems to be enhanced for trigeminal stimuli, presumably due to their exceptional biological relevance. Y1 - 2016 U6 - https://doi.org/10.1016/j.neuroimage.2016.03.026 SN - 1053-8119 VL - 134 SP - 386 EP - 395 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Balakrishnan, Karthikeyan A1 - Andrei-Selmer, Luminita-Cornelia A1 - Selmer, Thorsten A1 - Bacher, Michael A1 - Dodel, Richard T1 - Comparison of intravenous immunoglobulins for naturally occurring autoantibodies against amyloid-β JF - Journal of Alzheimer's Disease N2 - Intravenous immunoglobulins (IVIG) are currently used for therapeutic purposes in autoimmune disorders. Recently, we demonstrated the presence of naturally occurring antibodies against amyloid- β (nAbs-Aβ) within the pool of IVIG. In this study, we compared different brands of IVIG for nAbs-Aβ and have found differences in the specificity of the nAbs-Aβ towards Aβ1–40 and Aβ1–42 . We analyzed the influence of a pH-shift over the course of antibody storage using ELISA and investigated antibody dimerization at acidic and neutral pH as well as differences in the IgG subclass distributions among the IVIG using both HPLC and a nephelometric assay. Furthermore, we investigated the epitope region of purified nAbs-Aβ. The differences found in Aβ specificity are not directly proportionate to the binding nature of these antibodies when administered in vivo. This information, however, may serve as a guide when choosing the commercial source of IVIG for therapeutic applications in Alzheimer's disease Y1 - 2010 U6 - https://doi.org/10.3233/JAD-2010-1353 SN - 1387-2877 VL - 20 IS - 1 SP - 135 EP - 143 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Alexopoulos, Spiros A1 - Hoffschmidt, Bernhard T1 - Solar tower power plant in Germany and future perspectives of the development of the technology in Greece and Cyprus JF - Renewable Energy N2 - Since the 80s power production with solar thermal power plants has been a way to substitute fossil fuels. By concentrating direct solar radiation from heliostats very high temperatures of a thermal fluid can be reached. The resulting heat is converted to mechanical energy in a steam cycle which generates electricity. High efficiencies and fast start-up are reached by using air as a heat medium, as well as using porous ceramic materials as solar receiver of the concentrated sunlight. In Germany the construction of a 1.5 MWe solar tower power plant began in 2008. It is operational since December 2008 and started production of electricity in the spring of 2009. In Greece and Cyprus, countries with high solar potential, the development of this competitive solar thermal technology is imperative, since it has already been implemented in other Mediterranean countries. Y1 - 2010 U6 - https://doi.org/10.1016/j.renene.2009.11.003 SN - 0960-1481 VL - 35 IS - 7 SP - 1352 EP - 1356 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Orzada, Stephan A1 - Solbach, Klaus A1 - Gratz, Marcel A1 - Brunheim, Sascha A1 - Fiedler, Thomas M. A1 - Johst, Sören A1 - Bitz, Andreas A1 - Shooshtary, Samaneh A1 - Abuelhaija, Ashraf A1 - Voelker, Maximilian N. A1 - Rietsch, Stefan H. G. A1 - Kraff, Oliver A1 - Maderwald, Stefan A1 - Flöser, Martina A1 - Oehmingen, Mark A1 - Quick, Harald H. A1 - Ladd, Mark E. T1 - A 32-channel parallel transmit system add-on for 7T MRI JF - Plos one Y1 - 2019 U6 - https://doi.org/10.1371/journal.pone.0222452 ER - TY - CHAP A1 - Duprat, J. A1 - Dachwald, Bernd A1 - Hilchenbach, M. A1 - Engrand, Cecile A1 - Espe, C. A1 - Feldmann, Marco A1 - Francke, Gero A1 - Görög, Mark A1 - Lüsing, N. A1 - Langenhorst, Falko T1 - The MARVIN project: a micrometeorite harvester in Antarctic snow T2 - 44th Lunar and Planetary Science Conference N2 - MARVIN is an automated drilling and melting probe dedicated to collect pristine interplanetary dust particles (micrometeorites) from central Antarctica snow. Y1 - 2013 N1 - 44th Lunar and Planetary Science Conference, March 18-22, 2013, The Woodlands, Texas ER - TY - JOUR A1 - Rietsch, Stefan H. G. A1 - Brunheim, Sascha A1 - Orzada, Stephan A1 - Voelker, Maximilian N. A1 - Maderwald, Stefan A1 - Bitz, Andreas A1 - Gratz, Marcel A1 - Ladd, Mark E. A1 - Quick, Harald H. T1 - Development and evaluation of a 16-channel receive-only RF coil to improve 7T ultra-high field body MRI with focus on the spine JF - Magnetic Resonance in Medicine Y1 - 2019 U6 - https://doi.org/10.1002/mrm.27731 SN - 1522-2594 IS - Early view PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Baumann, Torsten A1 - Teixeira Boura, Cristiano José A1 - Göttsche, Joachim A1 - Hoffschmidt, Bernhard A1 - O'Connell, Bryan A1 - Schmitz, Stefan A1 - Zunft, Stefan T1 - Air/Sand heat exchanger design and materials for solar thermal power plant applications T2 - SolarPACES 2010 : the CSP Conference: electricity, fuels and clean water from concentrated solar energy ; 21 to 24 September 2010, Perpignan, France Y1 - 2010 SP - 146 EP - 147 PB - Soc. OSC CY - Saint Maur ER - TY - JOUR A1 - Mikucki, Jill Ann A1 - Schuler, C. G. A1 - Digel, Ilya A1 - Kowalski, Julia A1 - Tuttle, M. J. A1 - Chua, Michelle A1 - Davis, R. A1 - Purcell, Alicia A1 - Ghosh, D. A1 - Francke, G. A1 - Feldmann, Marco A1 - Espe, C. A1 - Heinen, Dirk A1 - Dachwald, Bernd A1 - Clemens, Joachim A1 - Lyons, W. B. A1 - Tulaczyk, S. T1 - Field-Based planetary protection operations for melt probes: validation of clean access into the blood falls, antarctica, englacial ecosystem JF - Astrobiology N2 - Subglacial environments on Earth offer important analogs to Ocean World targets in our solar system. These unique microbial ecosystems remain understudied due to the challenges of access through thick glacial ice (tens to hundreds of meters). Additionally, sub-ice collections must be conducted in a clean manner to ensure sample integrity for downstream microbiological and geochemical analyses. We describe the field-based cleaning of a melt probe that was used to collect brine samples from within a glacier conduit at Blood Falls, Antarctica, for geomicrobiological studies. We used a thermoelectric melting probe called the IceMole that was designed to be minimally invasive in that the logistical requirements in support of drilling operations were small and the probe could be cleaned, even in a remote field setting, so as to minimize potential contamination. In our study, the exterior bioburden on the IceMole was reduced to levels measured in most clean rooms, and below that of the ice surrounding our sampling target. Potential microbial contaminants were identified during the cleaning process; however, very few were detected in the final englacial sample collected with the IceMole and were present in extremely low abundances (∼0.063% of 16S rRNA gene amplicon sequences). This cleaning protocol can help minimize contamination when working in remote field locations, support microbiological sampling of terrestrial subglacial environments using melting probes, and help inform planetary protection challenges for Ocean World analog mission concepts. Y1 - 2023 U6 - https://doi.org/10.1089/ast.2021.0102 SN - 1557-8070 (online) SN - 153-1074 (print) VL - 23 IS - 11 SP - 1165 EP - 1178 PB - Liebert CY - New York, NY ER - TY - RPRT A1 - Feldmann, Marco A1 - Kuhnhenne, M. A1 - Döring, Bernd A1 - Pyschny, D. A1 - Lawson, R.M. A1 - Chuter, R.D. A1 - Boudjabeur, S. A1 - Lecomte-Labory, F. A1 - Airaksinen, M. A1 - Heikkinen, J. A1 - Laamanen, J. A1 - Albart, P. A1 - D'Haeyer, R. A1 - Chica, J.A. A1 - Maseda, J.M. A1 - Amundarain, A. A1 - Rips, M.O. A1 - Nuñez, J.A. A1 - Macías, O. A1 - Beguin, P. A1 - Ben Larbi, A. T1 - Energy and thermal improvements for construction in steel (ETHICS) - EUR 26010 N2 - ETHICS is concerned with evaluating, measuring and making improvements in the thermal and energy performance of steel-clad and steel-framed buildings. It addresses basic building physics performance at a laboratory and full-scale level, and the preparation of design guidance for commercial, industrial and residential buildings. It includes the development of design tools to assist users in assessing whole-building performance, and calibrates these tools against whole-building measurements, which will be obtained from this research. Opportunities for renewable energy and other energy-saving features will be assessed. This project focuses on objectives that are of particular interest for the design of new steel constructions regarding energy efficiency. ETHICS investigates the as-built performance by on-site tests regarding air tightness and heat transfer properties of the building envelope and by monitoring the energy consumption and thermal comfort of selected up-to-date steel buildings. As energy efficiency is a key requirement for design and construction of buildings in the future, this project provides well-founded scientific data, which prove the high energy performance of current steel constructions and work out details for further improvements to maintain and extend the position of steel products in the construction sector. KW - steel KW - metal structure KW - building technique KW - energy efficiency KW - thermal insulation KW - industrial research KW - research report Y1 - 2013 SN - 978-92-79-30789-8 U6 - https://doi.org/10.2777/17106 SN - 1831-9424 PB - Publications Office of the European Union CY - Luxembourg ER - TY - JOUR A1 - German, Laura A1 - Mikucki, Jill A. A1 - Welch, Susan A. A1 - Welch, Kathleen A. A1 - Lutton, Anthony A1 - Dachwald, Bernd A1 - Kowalski, Julia A1 - Heinen, Dirk A1 - Feldmann, Marco A1 - Francke, Gero A1 - Espe, Clemens A1 - Lyons, W. Berry T1 - Validation of sampling antarctic subglacial hypersaline waters with an electrothermal ice melting probe (IceMole) for environmental analytical geochemistry JF - International Journal of Environmental Analytical Chemistry N2 - Geochemical characterisation of hypersaline waters is difficult as high concentrations of salts hinder the analysis of constituents at low concentrations, such as trace metals, and the collection of samples for trace metal analysis in natural waters can be easily contaminated. This is particularly the case if samples are collected by non-conventional techniques such as those required for aquatic subglacial environments. In this paper we present the first analysis of a subglacial brine from Taylor Valley, (~ 78°S), Antarctica for the trace metals: Ba, Co, Mo, Rb, Sr, V, and U. Samples were collected englacially using an electrothermal melting probe called the IceMole. This probe uses differential heating of a copper head as well as the probe’s sidewalls and an ice screw at the melting head to move through glacier ice. Detailed blanks, meltwater, and subglacial brine samples were collected to evaluate the impact of the IceMole and the borehole pump, the melting and collection process, filtration, and storage on the geochemistry of the samples collected by this device. Comparisons between melt water profiles through the glacier ice and blank analysis, with published studies on ice geochemistry, suggest the potential for minor contributions of some species Rb, As, Co, Mn, Ni, NH4+, and NO2−+NO3− from the IceMole. The ability to conduct detailed chemical analyses of subglacial fluids collected with melting probes is critical for the future exploration of the hundreds of deep subglacial lakes in Antarctica. Y1 - 2021 U6 - https://doi.org/10.1080/03067319.2019.1704750 SN - 0306-7319 VL - 101 IS - 15 SP - 2654 EP - 2667 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Dachwald, Bernd A1 - Xu, Changsheng A1 - Feldmann, Marco A1 - Plescher, Engelbert T1 - IceMole : Development of a novel subsurface ice probe and testing of the first prototype on the Morteratsch Glacier T2 - EGU General Assembly 2011 Vienna | Austria | 03 – 08 April 2011 N2 - We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named “IceMole”, is currently developed, built, and tested at the FH Aachen University of Applied Sciences’ Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth). Y1 - 2011 ER - TY - JOUR A1 - Orzada, Stephan A1 - Bitz, Andreas A1 - Johst, Sören A1 - Gratz, Marcel A1 - Völker, Maximilian N. A1 - Kraff, Oliver A1 - Abuelhaija, Ashraf A1 - Fiedler, Thomas M. A1 - Solbach, Klaus A1 - Quick, Harald H. A1 - Ladd, Mark E. T1 - Analysis of an integrated 8-Channel Tx/Rx body array for use as a body coil in 7-Tesla MRI JF - Frontiers in Physics Y1 - 2017 U6 - https://doi.org/10.3389/fphy.2017.00017 SN - 2296-424X N1 - Article number 17 VL - 5 IS - Jun ER - TY - JOUR A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Abouzar, Maryam H. A1 - Wenmackers, Sylvia A1 - Janssens, Stoffel D. A1 - Haenen, Ken A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Capacitive field-effect (bio-)chemical sensors based on nanocrystalline diamond films JF - MRS Online Proceedings Library N2 - Capacitive field-effect electrolyte-diamond-insulator-semiconductor (EDIS) structures with O-terminated nanocrystalline diamond (NCD) as sensitive gate material have been realized and investigated for the detection of pH, penicillin concentration, and layer-by-layer adsorption of polyelectrolytes. The surface oxidizing procedure of NCD thin films as well as the seeding and NCD growth process on a Si-SiO2 substrate have been improved to provide high pH-sensitive, non-porous thin films without damage of the underlying SiO2 layer and with a high coverage of O-terminated sites. The NCD surface topography, roughness, and coverage of the surface groups have been characterized by SEM, AFM and XPS methods. The EDIS sensors with O-terminated NCD film treated in oxidizing boiling mixture for 45 min show a pH sensitivity of about 50 mV/pH. The pH-sensitive properties of the NCD have been used to develop an EDIS-based penicillin biosensor with high sensitivity (65-70 mV/decade in the concentration range of 0.25-2.5 mM penicillin G) and low detection limit (5 μM). The results of label-free electrical detection of layer-by-layer adsorption of charged polyelectrolytes are presented, too. Y1 - 2010 SN - 1946-4274 VL - 1203 PB - MRS CY - Warrendale ER - TY - CHAP A1 - Dachwald, Bernd A1 - Feldmann, Marco A1 - Espe, Clemens A1 - Plescher, Engelbert A1 - Konstantinidis, K. A1 - Forstner, R. T1 - Enceladus explorer - A maneuverable subsurface probe for autonomous navigation through deep ice T2 - 63rd International Astronautical Congress 2012, IAC 2012; Naples; Italy; 1 October 2012 through 5 October 2012. (Proceedings of the International Astronautical Congress, IAC ; 3) Y1 - 2012 SN - 978-1-62276-979-7 SP - 1756 EP - 1766 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Feldmann, Marco A1 - Döring, Bernd A1 - Pyschny, D. T1 - Floor systems; Sustainabilty analyses and assessments of steel bridges T2 - Sustainable steel buildings : a practical guide for structures and envelopes Y1 - 2016 SN - 978-1-118-74079-8 (PDF) SN - 978-1-118-74111-5 SP - 198 EP - 223 PB - Wiley Blackwell CY - Chichester, West Sussex ER - TY - JOUR A1 - Varriale, Ludovica A1 - Hengsbach, Jan-Niklas A1 - Guo, Tianyi A1 - Kuka, Katrin A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Sustainable production of lactic acid using a perennial ryegrass as feedstock—a comparative study of fermentation at the bench- and reactor-scale, and ensiling JF - Sustainability N2 - Perennial ryegrass (Lolium perenne) is an underutilized lignocellulosic biomass that has several benefits such as high availability, renewability, and biomass yield. The grass press-juice obtained from the mechanical pretreatment can be used for the bio-based production of chemicals. Lactic acid is a platform chemical that has attracted consideration due to its broad area of applications. For this reason, the more sustainable production of lactic acid is expected to increase. In this work, lactic acid was produced using complex medium at the bench- and reactor scale, and the results were compared to those obtained using an optimized press-juice medium. Bench-scale fermentations were carried out in a pH-control system and lactic acid production reached approximately 21.84 ± 0.95 g/L in complex medium, and 26.61 ± 1.2 g/L in press-juice medium. In the bioreactor, the production yield was 0.91 ± 0.07 g/g, corresponding to a 1.4-fold increase with respect to the complex medium with fructose. As a comparison to the traditional ensiling process, the ensiling of whole grass fractions of different varieties harvested in summer and autumn was performed. Ensiling showed variations in lactic acid yields, with a yield up to 15.2% dry mass for the late-harvested samples, surpassing typical silage yields of 6–10% dry mass. KW - lactobacillus KW - lactic acid KW - ensiling KW - fermentation KW - perennial ryegrass KW - renewable resources KW - bio-based economy Y1 - 2024 U6 - https://doi.org/10.3390/su16188054 SN - 2071-1050 N1 - This article belongs to the Section "Environmental Sustainability and Applications" VL - 16 IS - 18 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bäcker, Matthias A1 - Koch, Claudia A1 - Eiben, Sabine A1 - Geiger, Fania A1 - Eber, Fabian A1 - Gliemann, Hartmut A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors JF - Sensors and Actuators B: Chemical N2 - The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips. Y1 - 2017 U6 - https://doi.org/10.1016/j.snb.2016.07.096 SN - 0925-4005 VL - 238 SP - 716 EP - 722 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Koch, Claudia A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Schöning, Michael Josef ED - Wege, Christina T1 - TMV-Based Adapter Templates for Enhanced Enzyme Loading in Biosensor Applications T2 - Virus-Derived Nanoparticles for Advanced Technologies N2 - Nanotubular tobacco mosaic virus (TMV) particles and RNA-free lower-order coat protein (CP) aggregates have been employed as enzyme carriers in different diagnostic layouts and compared for their influence on biosensor performance. In the following, we describe a label-free electrochemical biosensor for improved glucose detection by use of TMV adapters and the enzyme glucose oxidase (GOD). A specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CP aggregates was achieved via bioaffinity binding. Glucose sensors with adsorptively immobilized [SA]-GOD, and with [SA]-GOD cross-linked with glutardialdehyde, respectively, were tested in parallel on the same sensor chip. Comparison of these sensors revealed that TMV adapters enhanced the amperometric glucose detection remarkably, conveying highest sensitivity, an extended linear detection range and fastest response times. These results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for applications in biosensorics and biochips. Here, we describe the fabrication and use of amperometric sensor chips combining an array of circular Pt electrodes, their loading with GOD-modified TMV nanotubes (and other GOD immobilization methods), and the subsequent investigations of the sensor performance. KW - Tobacco mosaic virus (TMV) KW - Coat protein KW - Enzyme nanocarrier KW - Glucose biosensor KW - Glucose oxidase Y1 - 2018 SN - 978-1-4939-7808-3 U6 - https://doi.org/10.1007/978-1-4939-7808-3 N1 - Methods in Molecular Biology, vol 1776 SP - 553 EP - 568 PB - Humana Press CY - New York, NY ER - TY - JOUR A1 - Koch, Claudia A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Wege, Christian T1 - Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors JF - Nanotheranostics N2 - The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts. Y1 - 2018 U6 - https://doi.org/10.7150/ntno.22114 SN - 2206-7418 VL - 2 IS - 2 SP - 184 EP - 196 PB - Ivyspring CY - Sydney ER -