TY  - JOUR
A1  - Bronder, Thomas
A1  - Jessing, Max P.
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors
JF  - Analytical Chemistry
N2  - Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.
Y1  - 2018
U6  - https://doi.org/10.1021/acs.analchem.8b01807
SN  - 0003-2700
VL  - 90
IS  - 12
SP  - 7747
EP  - 7753
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - THES
A1  - Bronder, Thomas
T1  - Label-free detection of tuberculosis DNA with capacitive field-effect biosensors
Y1  - 2020
U6  - https://doi.org/10.17192/z2021.0056
N1  - Dissertation, Universität, Marburg 2020
PB  - Philipps-Universität Marburg
CY  - Marburg
ER  - 
TY  - CHAP
A1  - Broenner, Simon
A1  - Höfken, Hans-Wilhelm
A1  - Schuba, Marko
T1  - Streamlining extraction and analysis of android RAM images
T2  - Proceedings of the 2nd international conference on information systems security and privacy
Y1  - 2016
SN  - 978-989-758-167-0
U6  - https://doi.org/10.5220/0005652802550264
SP  - 255
EP  - 264
ER  - 
TY  - CHAP
A1  - Brockmann, Carsten
A1  - Sultanow, Eldar
A1  - Czarnecki, Christian
ED  - Draude, Claude
ED  - Lange, Martin
ED  - Sick, Bernhard
T1  - Is enterprise architecture still relevant in the digital age?
T2  - GI Edition Proceedings Band 295 INFORMATIK 2019, Workshop-Beiträge
KW  - Preface
KW  - Enterprise Architecture
KW  - Digital Age
Y1  - 2019
SN  - 9783885796893
U6  - https://doi.org/10.18420/inf2019_ws01
SN  - 1617-5468
N1  - 50 Jahre Gesellschaft für Informatik – Informatik für Gesellschaft. 16. September, Kassel
SP  - 21
EP  - 21
PB  - Köllen
CY  - Bonn
ER  - 
TY  - CHAP
A1  - Brockmann, Carsten
A1  - Sultanow, Eldar
A1  - Czarnecki, Christian
ED  - Czarnecki, Christian
ED  - Brockmann, Carsten
ED  - Sultanow, Eldar
ED  - Koschmider, Agnes
ED  - Selzer, Annika
ED  - Gesellschaft für Informatik e. V., 
T1  - Enterprise architectures between agility and traditional methodologies
T2  - GI Edition Proceedings Band 285 Workshops der INFORMATIK 2018
N2  - For this year’s workshop on Enterpirse Architecture in Research and Practice we have received eight submissions from which four have passed the rigorous peer-review. The acceptance quote of 50% assures that only advancements in the field are included in our workshop.
KW  - Agility
KW  - agile
KW  - Enterprise Architecture
Y1  - 2018
SN  - 9783885796794
SN  - 1617-5468
N1  - 26.-27. September 2018 Berlin
PB  - Köllen
CY  - Bonn
ER  - 
TY  - JOUR
A1  - Brockhaus, Moritz K.
A1  - Behbahani, Mehdi
A1  - Muris, Farina
A1  - Jansen, Sebastian V.
A1  - Schmitz- Rode, Thomas
A1  - Steinseifer, Ulrich
A1  - Clauser, Johanna C.
T1  - In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept
JF  - Artificial Organs
N2  - Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.
Y1  - 2021
U6  - https://doi.org/10.1111/aor.14046
SN  - 1525-1594
VL  - 45
IS  - 12
SP  - 1513
EP  - 1521
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Britten, G.
A1  - Braun, Carsten
A1  - Hesse, M.
A1  - Ballmann, Josef
T1  - Computational aeroelasticity with reduced structural models
T2  - Flow modulation and fluid-structure interaction at airplane wings : research results of the Collaborative Research Center SFB 401 at RWTH Aachen, University of Technology, Aachen, Germany / Josef Ballmann (Ed.) Notes on numerical fluid mechanics and multidisciplinary design. Vol. 84
Y1  - 2003
SN  - 3-540-40209-8
SP  - 275
EP  - 299
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Breuß, Michael
A1  - Kleefeld, Andreas
T1  - Implicit monotone difference methods for scalar conservation laws with source terms
JF  - Acta Mathematica Vietnamica
N2  - In this article, a concept of implicit methods for scalar conservation laws in one or more spatial dimensions allowing also for source terms of various types is presented. This material is a significant extension of previous work of the first author (Breuß SIAM J. Numer. Anal. 43(3), 970–986 2005). Implicit notions are developed that are centered around a monotonicity criterion. We demonstrate a connection between a numerical scheme and a discrete entropy inequality, which is based on a classical approach by Crandall and Majda. Additionally, three implicit methods are investigated using the developed notions. Next, we conduct a convergence proof which is not based on a classical compactness argument. Finally, the theoretical results are confirmed by various numerical tests.
KW  - Entropy solution
KW  - Source term
KW  - Monotone methods
KW  - Implicit methods
KW  - Finite difference methods
KW  - Conservation laws
Y1  - 2020
U6  - https://doi.org/10.1007/s40306-019-00354-1
SN  - 2315-4144
N1  - Corresponding author: Andreas Kleefeld
VL  - 45
SP  - 709
EP  - 738
PB  - Springer Singapore
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Breuer, M.
A1  - Peterson, Leif Arne
A1  - Uibel, Thomas
T1  - Der Studiengang Holzingenieurwesen der Fachhochschule Aachen
JF  - Jahrbuch des Kreises Euskirchen 2014
Y1  - 2013
SP  - 165
EP  - 168
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Raue, Markus
A1  - Strobel, M.
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, R.
A1  - Wagner, Torsten
T1  - Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems
JF  - Physica status solidi (a)
N2  - Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium.
Y1  - 2016
U6  - https://doi.org/10.1002/pssa.201533056
SN  - 1862-6300
VL  - 213
IS  - 6
SP  - 1520
EP  - 1525
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Breuer, Lars
A1  - Raue, Markus
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Light-stimulated hydrogel actuators with incorporated graphene oxide for microfluidic applications
T2  - 12. Dresdner Sensor-Symposium 2015
Y1  - 2015
U6  - https://doi.org/10.5162/12dss2015/P5.8
SP  - 206
EP  - 209
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Raue, Markus
A1  - Kirschbaum, M.
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, R.
A1  - Wagner, Torsten
T1  - Light-controllable polymeric material based on temperature-sensitive hydrogels with incorporated graphene oxide
JF  - Physica status solidi (a)
N2  - Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel films with incorporated graphene oxide (GO) were developed and tested as light-stimulated actuators. GO dispersions were synthesized via Hummers method and characterized toward their optical properties and photothermal energy conversion. The hydrogels were prepared by means of photopolymerization. In addition, the influence of GO within the hydrogel network on the lower critical solution temperature (LCST) was investigated by differential scanning calorimetry (DSC). The optical absorbance and the response to illumination were determined as a function of GO concentration for thin hydrogel films. A proof of principle for the stimulation with light was performed.
Y1  - 2015
U6  - https://doi.org/10.1002/pssa.201431944
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1368
EP  - 1374
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Pilas, Johanna
A1  - Guthmann, Eric
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Towards light-addressable flow control: responsive hydrogels with incorporated graphene oxide as laser-driven actuator structures within microfluidic channels
JF  - Sensor and Actuators B: Chemical
Y1  - 2019
U6  - https://doi.org/10.1016/j.snb.2019.02.086
SN  - 0925-4005
VL  - 288
SP  - 579
EP  - 585
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Investigation of the spatial resolution of a laser-based stimulation process for light-addressable hydrogels with incorporated graphene oxide by means of IR thermography
JF  - Sensors and Actuators A: Physical
Y1  - 2017
U6  - https://doi.org/10.1016/j.sna.2017.11.031
SN  - 0924-4247
VL  - 268
SP  - 126
EP  - 132
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Breuer, Lars
A1  - Guthmann, Eric
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Light-Stimulated Hydrogels with Incorporated Graphene Oxide as Actuator Material for Flow Control in Microfluidic Applications
T2  - Proceedings Eurosensors 2017 Conference, Paris, France, 3–6 September 2017
Y1  - 2017
U6  - https://doi.org/10.3390/proceedings1040524
SP  - 1
EP  - 4
ER  - 
TY  - JOUR
A1  - Bressel, A.
A1  - Schultze, J.W.
A1  - Khan, W.
A1  - Wolfaardt, G. M.
A1  - Rohns, H.-P.
A1  - Irmscher, R.
A1  - Schöning, Michael Josef
T1  - High resolution gravimetric, optical and electrochemical investigations of microbial biofilm formation in aqueous systems
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SN  - 0013-4686
SP  - 3363
EP  - 3372
ER  - 
TY  - JOUR
A1  - Breitschuh, S.
A1  - Graber, S.
A1  - Hagemann, Hans-Jürgen
A1  - Hemdt, A. vom
A1  - Schmitz, Günter
T1  - Telematiklabore mit LabVIEW in der Ingenieurausbildung
JF  - Virtuelle Instrumente in der Praxis : Messtechnik, Automatisierung ; Begleitband zum Kongress VIP 2003 / Rahman Jamal ; Hans Jaschinski (Hrsg.).
Y1  - 2003
SN  - 3-7785-2908-0
N1  - VIP <2003, München>
SP  - 458
EP  - 464
PB  - Hüthig
CY  - Heidelberg [u.a.]
ER  - 
TY  - BOOK
A1  - Breitbach, Gerd
A1  - Wolters, Johannes
T1  - Sicherheitstechnische Untersuchungen zum Störfallverhalten des HTR-100 : Ergänzungsband mit vertiefenden Einzelbeiträgen zum Bericht Jül-Spez-477 / J. Wolters ... G. Breitbach ...
Y1  - 1991
N1  - (Berichte des Forschungszentrums Jülich ; 2539)
PB  - Forschungszentrum Jülich, Zentralbibliothek
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Breitbach, Gerd
A1  - Wolters, J.
T1  - Der sowjetische Druckröhren-Siedewasserreaktor / J. Wolters ; G. Breitbach
JF  - Atomwirtschaft - Atomtechnik. 31 (1986), H. 6
Y1  - 1986
SN  - 0004-721x
N1  - 2. ISSN: 0365-8414
SP  - 286
EP  - 289
ER  - 
TY  - BOOK
A1  - Breitbach, Gerd
A1  - Wolters, Hans Jörg
T1  - Untersuchungen zum Ratcheting von Segmenten der "Ersten Wand" zukünftiger Fusionsreaktoren unter zyklischer thermischer und mechanischer Belastung / J. Wolters ; G. Breitbach ...
Y1  - 1996
N1  - Zugl: Aachen, Techn. Hochsch., Diss., 1996. - (Berichte des Forschungszentrums Jülich ; 3250). - Report-Nr.: Jül 3250
PB  - Forschungszentrum Jülich, Zentralbibl.
CY  - Jülich
ER  -