TY  - JOUR
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Xenobiotic receptor humanized mice and their utility
JF  - Drug Metabolism Reviews
Y1  - 2013
U6  - https://doi.org/10.3109/03602532.2012.738687
SN  - 1097-9883
IS  - 1
SP  - 110
EP  - 121
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Henderson, Colin J.
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man
JF  - Expert Review of Clinical Pharmacology
Y1  - 2009
U6  - https://doi.org/10.1586/17512433.2.2.105
SN  - 1751-2441
VL  - 2
IS  - 2
SP  - 105
EP  - 109
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Stanley, Lesley A.
A1  - Horsburgh, Brian C.
A1  - Ross, Jillian
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior
JF  - Drug Metabolism Reviews
Y1  - 2009
U6  - https://doi.org/10.1080/03602530802605040
SN  - 1097-9883
VL  - 41
IS  - 1
SP  - 27
EP  - 65
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Stanley, Lesley A.
A1  - Horsburgh, Brian C.
A1  - Ross, Jillian
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Nuclear Receptors which play a pivotal role in drug disposition and chemical toxicity
JF  - Drug Metabolism Reviews
Y1  - 2006
U6  - https://doi.org/10.1080/03602530600786232
SN  - 1097-9883
VL  - 38
IS  - 3
SP  - 515
EP  - 597
ER  - 
TY  - CHAP
A1  - Samuelsson, K.
A1  - Scheer, Nico
A1  - Wilson, I.
A1  - Wolf, C.R.
A1  - Henderson, C.J.
ED  - Chackalamannil, Samuel
T1  - Genetically Humanized Animal Models
T2  - Comprehensive Medicinal Chemistry III. 3rd Edition
N2  - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
KW  - Chimeric liver-humanized mice
KW  - Drug distribution
KW  - Drug metabolism
KW  - Toxicology
KW  - Knockout mice
Y1  - 2017
SN  - 978-0-12-803201-5
U6  - https://doi.org/10.1016/B978-0-12-409547-2.12376-5
SP  - 130
EP  - 149
PB  - Elsevier
CY  - Saint Louis
ER  - 
TY  - CHAP
A1  - Scheer, Nico
A1  - Chu, Xiaoyan
A1  - Salphati, Laurent
A1  - Zamek-Gliszczynski, Maciej J.
ED  - Nicholls, Glynis
T1  - Knockout and humanized animal models to study membrane transporters in drug development
T2  - Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development
Y1  - 2016
SN  - 978-1-78262-379-3
U6  - https://doi.org/10.1039/9781782623793-00298
SP  - 298
EP  - 332
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Braband, Henrik
A1  - Paulßen, Elisabeth
A1  - Abram, Ulrich
T1  - Nitridorhenium(V) Complexes with 1,3-Dialkyl-4,5-dimethylimidazole-2-ylidenes
JF  - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry
Y1  - 2006
U6  - https://doi.org/10.1002/zaac.200600002
SN  - 1521-3749
VL  - 632
IS  - 6
SP  - 1051
EP  - 1056
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Schweighöfer, Philip V.
A1  - Abram, Ulrich
T1  - Reactions of [ReOX3(PPh3)2] Complexes (X = Cl, Br) with Phenylacetylene and the Structures of the Products
JF  - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry
N2  - Oxorhenium(V) complexes [ReOX3(PPh3)2] (X = Cl, Br) react with phenylacetylene under formation of complexes with ylide-type ligands. Compounds of the compositions [ReOCl3(PPh3){C(Ph)C(H)(PPh3)}] (1), [ReOBr3(OPPh3){C(Ph)C(H)(PPh3)}] (2), and [ReOBr3(OPPh3){C(H)C(Ph)(PPh3)}] (3) were isolated and characterized by X-ray diffraction. They contain a ligand, which was formed by a nucleophilic attack of released PPh3 at coordinated phenylacetylene. The structures of the products show that there is no preferable position for this attack. Cleavage of the Re–C bond in 3 and dimerization of the organic ligand resulted in the formation of the [{(PPh3)(H)CC(Ph)}2]2+ cation, which crystallized as its [(ReOBr4)(OReO3)]2– salt.
Y1  - 2010
U6  - https://doi.org/10.1002/zaac.200900478
SN  - 1521-3749
VL  - 636
IS  - 5
SP  - 779
EP  - 783
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Kückmann, Theresa
A1  - Abram, Ulrich
T1  - Silver(I) Complexes of 1,3-Dialkyl-4,5-dimethylimidazol-2-ylidenes and their Use as Precursors for the Synthesis of Rhenium(V) NHC Complexes
JF  - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry
Y1  - 2007
U6  - https://doi.org/10.1002/zaac.200700021
SN  - 1521-3749
VL  - 633
IS  - 5-6
SP  - 830
EP  - 834
ER  - 
TY  - JOUR
A1  - Braband, Henrik
A1  - Yegen, Eda
A1  - Paulßen, Elisabeth
A1  - Abram, Ulrich
T1  - [{ReN(PMe2Ph)3}{ReO3N}]2 – Structural Evidence for the Nitridotrioxorhenate(VII) Anion, [ReO3N]2−
JF  - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry
Y1  - 2005
U6  - https://doi.org/10.1002/zaac.200500240
SN  - 1521-3749
VL  - 631
IS  - 12
SP  - 2408
EP  - 2410
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Alberto, Roger
A1  - Abram, Ulrich
T1  - Synthesis, Characterization, and Structures of R3EOTcO3 Complexes (E = C, Si, Ge, Sn, Pb) and Related Compounds
JF  - Inorganic Chemistry
N2  - AgTcO4 reacts with R3ECl compounds (E = C, Si, Ge, Sn, Pb; R = Me, iPr, tBu, Ph), tBu2SnCl2, or PhMgCl under formation of novel trioxotechnetium(VII) derivatives. The carbon and silicon derivatives readily undergo decomposition, which was proven by 99Tc NMR spectroscopy and the isolation of decomposition products such as [TcOCl3(THF)(OH2)]. Compounds [Ph3GeOTcO3], [(THF)Ph3SnOTcO3], [(O3TcO)SntBu2(OH)]2, and [(THF)4Mg(OTcO3)2] are more stable and were isolated in crystalline form and characterized by X-ray diffraction.
Y1  - 2010
U6  - https://doi.org/10.1021/ic1001094
SN  - 1520-510X
VL  - 49
IS  - 7
SP  - 3525
EP  - 3530
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Kong, Shushu
A1  - Arciszewski, Pawel
A1  - Wielbalck, Swantje
A1  - Abram, Ulrich
T1  - Aryl and NHC Compounds of Technetium and Rhenium
JF  - Journal of the American Chemical Society
N2  - Air- and water-stable phenyl complexes with nitridotechnetium(V) cores can be prepared by straightforward procedures. [TcNPh2(PPh3)2] is formed by the reaction of [TcNCl2(PPh3)2] with PhLi. The analogous N-heterocyclic carbene (NHC) compound [TcNPh2(HLPh)2], where HLPh is 1,3,4-triphenyl-1,2,4-triazol-5-ylidene, is available from (NBu4)[TcNCl4] and HLPh or its methoxo-protected form. The latter compound allows the comparison of different Tc–C bonds within one compound. Surprisingly, the Tc chemistry with such NHCs does not resemble that of corresponding Re complexes, where CH activation and orthometalation dominate.
Y1  - 2012
U6  - https://doi.org/10.1021/ja3033718
SN  - 1520-5126
VL  - 134
IS  - 22
SP  - 9118
EP  - 9121
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Barbazán, Paula
A1  - Hagenbach, Adelheid
A1  - Paulßen, Elisabeth
A1  - Abram, Ulrich
A1  - Carballo, Rosa
A1  - Rodriguez-Hermida, Sabina
A1  - Vázquez-López, Ezequiel M.
T1  - Tricarbonyl Rhenium(I) and Technetium(I) Complexes with Hydrazones Derived from 4,5-Diazafluoren-9-one and 1,10-Phenanthroline-5,6-dione
JF  - European Journal of Inorganic Chemistry
N2  - Tricarbonylrhenium(I) and -technetium(I) halide (halide = Cl and Br) complexes of ligands derived from 4,5-diazafluoren-9-one (df) and 1,10-phenanthroline-5,6-dione (phen) derivatives of benzoic and 2-hydroxybenzoic acid hydrazides have been prepared. The complexes have been characterized by elemental analysis, MS, IR, 1H NMR and absorption and emission UV/Vis spectroscopic methods. The metal centres (ReI and TcI) are coordinated through the nitrogen imine atoms and establish five-membered chelate rings, whereas the hydrazone groups stand uncoordinated. The 1H NMR spectra suggest the same behaviour in solution on the basis of only marginal variations in the chemical shifts of the hydrazine protons.
Y1  - 2010
U6  - https://doi.org/10.1002/ejic.201000522
SN  - 1099-0682
IS  - 29
SP  - 4622
EP  - 4630
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Ngyugen, Hung Huy
A1  - Kahlcke, Nils
A1  - Deflon, Victor M.
A1  - Abram, Ulrich
T1  - Tricarbonyltechnetium(I) and -rhenium(I) complexes with N′-thiocarbamoylpicolylbenzamidines
JF  - Polyhedron
N2  - N,N-Dialkylamino(thiocarbonyl)-N′-picolylbenzamidines react with (NEt4)2[M(CO)3X3] (M = Re, X = Br; M = Tc, X = Cl) under formation of neutral [M(CO)3L] complexes in high yields. The monoanionic NNS ligands bind in a facial coordination mode and can readily be modified at the (CS)NR1R2 moiety. The complexes [99Tc(CO)3(LPyMor)] and [Re(CO)3(L)] (L = LPyMor, LPyEt) were characterized by X-ray diffraction. Reactions of [99mTc(CO)3(H2O)3]+ with the N′-thiocarbamoylpicolylbenzamidines give the corresponding 99mTc complexes. The ester group in HLPyCOOEt allows linkage between biomolecules and the metal core.
Y1  - 2012
U6  - https://doi.org/10.1016/j.poly.2012.04.008
SN  - 0277-5387
VL  - 40
IS  - 1
SP  - 153
EP  - 158
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Pellegrini, Paul A.
A1  - Howell, Nicholas R.
A1  - Shepherd, Rachael K.
A1  - Lengkeek, Nigel A.
A1  - Paulßen, Elisabeth
A1  - Katsifis, Andrew G.
A1  - Greguric, Ivan
T1  - Synthesis and Radiolabelling of DOTA-Linked Glutamine Analogues with 67,68Ga as Markers for Increased Glutamine Metabolism in Tumour Cells
JF  - Molecules
Y1  - 2013
U6  - https://doi.org/10.3390/molecules18067160
SN  - 1420-3049
VL  - 18
IS  - 6
SP  - 7160
EP  - 7178
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Le, Van So
A1  - Lengkeek, Nigel
A1  - Pellegrini, Paul
A1  - Jackson, Tim
A1  - Greguric, Ivan
A1  - Weiner, Ron
T1  - Influence of Metal Ions on the 68Ga-labeling of DOTATATE
JF  - Applied Radiation and Isotopes
Y1  - 2013
U6  - https://doi.org/10.1016/j.apradiso.2013.08.010
SN  - 1872-9800
VL  - 82
SP  - 232
EP  - 238
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Lengkeek, Nigel A.
A1  - Le, Van So
A1  - Pellegrini, Paul A.
A1  - Greguric, Ivan
A1  - Weiner, Ron
T1  - The role of additives in moderating the influence of Fe(III) and Cu(II) on the radiochemical yield of [⁶⁸Ga(DOTATATE)]
JF  - Applied Radiation and Isotopes
N2  - [⁶⁸Ga(DOTATATE)] has demonstrated its clinical usefulness. Both Fe³⁺ and Cu²⁺, potential contaminants in Gallium-68 generator eluent, substantially reduce the radiochemical (RC) yield of [⁶⁸Ga(DOTATATE)] if the metal/ligand ratio of 1:1 is exceeded. A variety of compounds were examined for their potential ability to reduce this effect. Most had no effect on RC yield. However, addition of phosphate diminished the influence of Fe³⁺ by likely forming an insoluble iron salt. Addition of ascorbic acid reduced Cu²⁺ and Fe³⁺ to Cu⁺ and Fe²⁺ respectively, both of which have limited impact on RC yields. At low ligand amounts (5 nmol DOTATATE), the addition of 30 nmol phosphate (0.19 mM) increased the tolerance of Fe3⁺ from 4 nmol to 10 nmol (0.06 mM), while the addition of ascorbic acid allowed high RC yields (>95%) in the presence of 40 nmol Fe³⁺ (0.25 mM) and 100 nmol Cu²⁺ (0.63 mM). The effect of ascorbic acid was highly pH-dependant, and gave optimal results at pH 3.
Y1  - 2016
U6  - https://doi.org/10.1016/j.apradiso.2015.09.008
SN  - 1872-9800
VL  - 107
SP  - 13
EP  - 16
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Hoehr, Cornelia
A1  - Hou, Xinchi
A1  - Hanemaayer, Victoire
A1  - Zeisler, Stefan
A1  - Adam, Michael J.
A1  - Ruth, Thomas J.
A1  - Celler, Anna
A1  - Buckley, Ken
A1  - Benard, Francois
A1  - Schaffer, Paul
T1  - Production of Y-86 and other radiometals for research purposes using a solution target system
JF  - Nuclear medicine and biology
Y1  - 2015
U6  - https://doi.org/10.1016/j.nucmedbio.2015.06.005
SN  - 1872-9614
VL  - 42
IS  - 11
SP  - 842
EP  - 849
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hoehr, Cornelia
A1  - Paulßen, Elisabeth
A1  - Benard, Francois
A1  - Lee, Chris Jaeil
A1  - Hou, Xinchi
A1  - Badesso, Brian
A1  - Ferguson, Simon
A1  - Miao, Qing
A1  - Yang, Hua
A1  - Buckley, Ken
A1  - Hanemaayer, Victoire
A1  - Zeisler, Stefan
A1  - Ruth, Thomas
A1  - Celler, Anna
A1  - Schaffer, Paul
T1  - ⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron
JF  - Nuclear medicine and biology
N2  - Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.
Y1  - 2014
U6  - https://doi.org/10.1016/j.nucmedbio.2013.12.016
SN  - 1872-9614
VL  - 41
IS  - 5
SP  - 401
EP  - 406
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Infantino, Angelo
A1  - Paulßen, Elisabeth
A1  - Mostacci, Domiziano
A1  - Schaffer, Paul
A1  - Trinczek, Michael
A1  - Hoehr, Cornelia
T1  - Assessment of the production of medical isotopes using the Monte Carlo code FLUKA: Simulations against experimental measurements
JF  - Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
N2  - The Monte Carlo code FLUKA is used to simulate the production of a number of positron emitting radionuclides, ¹⁸F, ¹³N, ⁹⁴Tc, ⁴⁴Sc, ⁶⁸Ga, ⁸⁶Y, ⁸⁹Zr, ⁵²Mn, ⁶¹Cu and ⁵⁵Co, on a small medical cyclotron with a proton beam energy of 13 MeV. Experimental data collected at the TR13 cyclotron at TRIUMF agree within a factor of 0.6 ± 0.4 with the directly simulated data, except for the production of ⁵⁵Co, where the simulation underestimates the experiment by a factor of 3.4 ± 0.4. The experimental data also agree within a factor of 0.8 ± 0.6 with the convolution of simulated proton fluence and cross sections from literature. Overall, this confirms the applicability of FLUKA to simulate radionuclide production at 13 MeV proton beam energy.
Y1  - 2016
U6  - https://doi.org/10.1016/j.nimb.2015.10.067
SN  - 1872-9584
VL  - 366
SP  - 117
EP  - 123
PB  - Elsevier
CY  - Amsterdam
ER  -