TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Schütz, S. A1 - Epanya, P. A1 - Steffen, A. A1 - Weißbecker, B. A1 - Hummel, Hans E. A1 - Kordos, P. A1 - Lüth, H. T1 - Improving the bioelectronic interface of an antenna/chip biosensor – technological aspects JF - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1. Y1 - 1999 SN - 90-76699-02-X N1 - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague) SP - 569 EP - 572 CY - The Hague, The Netherlands ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Weißbecker, B. A1 - Hummel, Hans E. A1 - Schütz, S. T1 - Extending the capabilities of an antenna/chip biosensor by employing various insect species JF - Sensors and Actuators B. 78 (2001), H. 1-3 Y1 - 2001 SN - 0925-4005 SP - 1 EP - 5 ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Weißbecker, B. A1 - Hummel, Hans E. A1 - Schütz, S. T1 - Extending the capabilities of an antenna/chip biosensor by employing various insect species JF - Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...] Y1 - 2000 SN - 87-89935-50-0 N1 - Eurosensors ; (14, 2000, København) ; Eurosensors ; (14 : ; 2000.08.27-30 : ; Copenhagen) ; European Conference on Solid-State Transducers ; (14 : ; 2000.08.27-30 : ; Copenhagen) SP - 27 EP - 30 PB - MIC, Mikroelektronik Centret CY - Lyngby, Denmark ER - TY - JOUR A1 - Schroth, P. A1 - Schöning, Michael Josef A1 - Kordos, P. A1 - Lüth, H. A1 - Schütz, S. A1 - Weißbecker, B. A1 - Hummel, Hans E. T1 - Insectbased BioFETs with improved signal characteristics JF - Biosensors & Bioelectronics. 14 (1999), H. 3 Y1 - 1999 SN - 0956-5663 SP - 303 EP - 308 ER - TY - JOUR A1 - Schroth, P. A1 - Lüth, H. A1 - Hummel, Hans E. A1 - Schütz, S. A1 - Schöning, Michael Josef T1 - Characterising an insect antenna as a receptor for a biosensor by means of impedance spectroscopy JF - Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz Y1 - 2001 SN - 0-08-044014-2 SP - 293 EP - 297 PB - Elsevier [u.a.] CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Scholl, Fabio A1 - Morais, Paulo A1 - Gabriel, Rayla A1 - Schöning, Michael Josef A1 - Siqueira, Jose Roberto, Jr. A1 - Caseli, Luciano T1 - Carbon nanotubes arranged as smart interfaces in lipid Langmuir-Blodgett films enhancing the enzymatic properties of penicillinase for biosensing applications JF - Applied Materials & Interfaces N2 - In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir–Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air–water interface was investigated by surface pressure–area isotherms, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy. Enzyme activity was studied with UV–vis spectroscopy and the feasibility of the supramolecular device nanostructured as ultrathin films were essayed in a capacitive electrolyte–insulator–semiconductor (EIS) sensor device. The presence of CNTs in the enzyme–lipid LB film not only tuned the catalytic activity of penicillinase but also helped conserve its enzyme activity after weeks, showing increased values of activity. Viability as penicillin sensor was demonstrated with capacitance/voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results may be related not only to the nanostructured system provided by the film, but also to the synergism between the compounds on the active layer, leading to a surface morphology that allowed a fast analyte diffusion because of an adequate molecular accommodation, which also preserved the penicillinase activity. This work therefore demonstrates the feasibility of employing LB films composed of lipids, CNTs, and enzymes as EIS devices for biosensing applications. Y1 - 2017 U6 - http://dx.doi.org/10.1021/acsami.7b08095 SN - 1944-8252 VL - 9 IS - 36 SP - 31054 EP - 31066 PB - ACS CY - Washington ER - TY - JOUR A1 - Schoenrock, Britt A1 - Muckelt, Paul E. A1 - Hastermann, Maria A1 - Albracht, Kirsten A1 - MacGregor, Robert A1 - Martin, David A1 - Gunga, Hans-Christian A1 - Salanova, Michele A1 - Stokes, Maria J. A1 - Warner, Martin B. A1 - Blottner, Dieter T1 - Muscle stiffness indicating mission crew health in space JF - Scientific Reports N2 - Muscle function is compromised by gravitational unloading in space affecting overall musculoskeletal health. Astronauts perform daily exercise programmes to mitigate these effects but knowing which muscles to target would optimise effectiveness. Accurate inflight assessment to inform exercise programmes is critical due to lack of technologies suitable for spaceflight. Changes in mechanical properties indicate muscle health status and can be measured rapidly and non-invasively using novel technology. A hand-held MyotonPRO device enabled monitoring of muscle health for the first time in spaceflight (> 180 days). Greater/maintained stiffness indicated countermeasures were effective. Tissue stiffness was preserved in the majority of muscles (neck, shoulder, back, thigh) but Tibialis Anterior (foot lever muscle) stiffness decreased inflight vs. preflight (p < 0.0001; mean difference 149 N/m) in all 12 crewmembers. The calf muscles showed opposing effects, Gastrocnemius increasing in stiffness Soleus decreasing. Selective stiffness decrements indicate lack of preservation despite daily inflight countermeasures. This calls for more targeted exercises for lower leg muscles with vital roles as ankle joint stabilizers and in gait. Muscle stiffness is a digital biomarker for risk monitoring during future planetary explorations (Moon, Mars), for healthcare management in challenging environments or clinical disorders in people on Earth, to enable effective tailored exercise programmes. KW - Ageing KW - Anatomy KW - Muscle KW - Musculoskeletal system KW - Physiology Y1 - 2024 U6 - http://dx.doi.org/10.1038/s41598-024-54759-6 SN - 2045-2322 N1 - Corresponding author: Dieter Blottner VL - 14 IS - Article number: 4196 PB - Springer Nature CY - London ER - TY - JOUR A1 - Schneider, Jules A1 - Schwabedal, Justus T. C. A1 - Bialonski, Stephan T1 - Schlafspindeln – Funktion, Detektion und Nutzung als Biomarker für die psychiatrische Diagnostik JF - Der Nervenarzt N2 - Hintergrund: Die Schlafspindel ist ein Graphoelement des Elektroenzephalogramms (EEG), das im Leicht- und Tiefschlaf beobachtet werden kann. Veränderungen der Spindelaktivität wurden für verschiedene psychiatrische Erkrankungen beschrieben. Schlafspindeln zeigen aufgrund ihrer relativ konstanten Eigenschaften Potenzial als Biomarker in der psychiatrischen Diagnostik. Methode: Dieser Beitrag liefert einen Überblick über den Stand der Wissenschaft zu Eigenschaften und Funktionen der Schlafspindeln sowie über beschriebene Veränderungen der Spindelaktivität bei psychiatrischen Erkrankungen. Verschiedene methodische Ansätze und Ausblicke zur Spindeldetektion werden hinsichtlich deren Anwendungspotenzial in der psychiatrischen Diagnostik erläutert. Ergebnisse und Schlussfolgerung: Während Veränderungen der Spindelaktivität bei psychiatrischen Erkrankungen beschrieben wurden, ist deren exaktes Potenzial für die psychiatrische Diagnostik noch nicht ausreichend erforscht. Diesbezüglicher Erkenntnisgewinn wird in der Forschung gegenwärtig durch ressourcenintensive und fehleranfällige Methoden zur manuellen oder automatisierten Spindeldetektion ausgebremst. Neuere Detektionsansätze, die auf Deep-Learning-Verfahren basieren, könnten die Schwierigkeiten bisheriger Detektionsmethoden überwinden und damit neue Möglichkeiten für die praktisch KW - Schlafspindeldetektion KW - Psychiatrische Biomarker KW - · Psychiatrische Erkrankungen/Diagnostik KW - Elektroenzephalographie KW - Deep Learning Y1 - 2022 U6 - http://dx.doi.org/10.1007/s00115-022-01340-z SN - 1433-0407 SP - 1 EP - 8 PB - Springer CY - Berlin, Heidelberg ER - TY - JOUR A1 - Schmitt, G. A1 - Werner, C. A1 - Schöning, Michael Josef T1 - Microelectrochemical efficiency evaluation of inhibitors for CO2 corrosion of carbon steel under high shear stress gradients JF - Corrosion 2002. Conference Proceedings. NACExpo, 57th Annual Conference and Exhibition, Denver, US, Apr 7-11, 2002 Y1 - 2002 N1 - Paper 02280 SP - 1 EP - 11 PB - NACE International CY - Houston, Texas ER - TY - JOUR A1 - Schmitt, G. A1 - Schultze, J.-W. A1 - Faßbender, F. A1 - Buß, G. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Passivation and corrosion of microelectrode arrays JF - Electrochimica Acta. 44 (1999), H. 21-22 Y1 - 1999 SN - 0013-4686 SP - 3865 EP - 3883 ER - TY - JOUR A1 - Schmitt, G. A1 - Faßbender, F. A1 - Lüth, H. A1 - Schöning, Michael Josef A1 - Schultze, J. W. A1 - Buß, G. T1 - Passivation and corrosion of microelectrode arrays JF - Materials and Corrosion. 51 (2000), H. 1 Y1 - 2000 SN - 0947-5117 SP - 20 EP - 25 ER - TY - JOUR A1 - Schmitt, G. A1 - Faßbender, F. A1 - Lüth, H. A1 - Schöning, Michael Josef A1 - Buss, G. A1 - Kranzmann, A. A1 - Gramberg, U. T1 - Korrosionsschutzwirkung von Passivierungsschichten am Beispiel eines Mikroelektrodenarrays JF - Werkstoffe für die Energietechnik / Symposium 3 Y1 - 1999 SN - 3-527-29940-8 N1 - Serie Werkstoffwoche '98 ; 3 SP - 345 EP - 350 PB - Wiley-VCH CY - Weinheim [u.a.] ER - TY - JOUR A1 - Schmidt, Daniela A1 - Langen, Karl-J. A1 - Herzog, Hans A1 - Wirths, Jochen A1 - Holschbach, Markus A1 - Kiwit, Jürgen C. W. A1 - Ziemons, Karl A1 - Coenen, Heinz-H. A1 - Müller-Gärtner, Hans-W. T1 - Whole-body kinetics and dosimetry of L-3[123I]-iodo-α-methyltyrosine JF - European Journal of Nuclear Medicine Y1 - 1997 SN - 1619-7089 VL - 24 IS - 9 SP - 1162 EP - 1166 ER - TY - JOUR A1 - Schindler, Kaspar A. A1 - Bialonski, Stephan A1 - Horstmann, Marie-Therese A1 - Elger, Christian E. A1 - Lehnertz, Klaus T1 - Evolving functional network properties and synchronizability during human epileptic seizures JF - Chaos: An Interdisciplinary Journal of Nonlinear Science Y1 - 2008 U6 - http://dx.doi.org/10.1063/1.2966112 SN - 1089-7682 VL - 18 IS - 3 SP - 033119 ER - TY - JOUR A1 - Schieren, Mark A1 - Kleinschmidt, Joris A1 - Schmutz, Axel A1 - Loop, Torsten A1 - Gatzweiler, Karl-Heinz A1 - Staat, Manfred A1 - Wappler, Frank A1 - Defosse, Jerome T1 - Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study JF - Anaesthesia Y1 - 2019 SN - 1365-2044 U6 - http://dx.doi.org/10.1111/anae.14815 N1 - Die Anhänge "Table S1 (Impact of sex and level of training on dental force. Results presented as median (IQR [range]) and n (%))" und "Appendix S1 (Measurement technique.)" stehen unter "Supporting Information" zum Download bereit. VL - 74 IS - 12 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Schelthoff, Christof A1 - Steffen, Bernhard A1 - Weidner, Peter A1 - Hoßfeld, Friedel T1 - Hochauflösende Modellierung von SOFC-Brennstoffzellen / Schelthoff, Christof ; Steffen, Bernhard ; Weidner, Peter ; Hoßfeld, Friedel ; Divisek, J. ; Jung, Rita JF - Mathematik : Schlüsseltechnologie für die Zukunft ; Verbundprojekte zwischen Universität und Industrie ; mit 33 Tabellen / Karl-Heinz Hoffmann ... (Hrsg.) Y1 - 1997 SN - 3-540-61677-2 N1 - auch unter der Signatur 21 TLK 446 vorhanden SP - 105 EP - 115 PB - Springer CY - Berlin ER - TY - JOUR A1 - Schelthoff, Christof A1 - Steffen, Bernhard T1 - Modellierung und Simulation am Beispiel von Hochtemperatur-Brennstoffzellen JF - Praxis der Informationsverarbeitung und Kommunikation : PIK. 19 (1996), H. 3 Y1 - 1996 SN - 0930-5157 N1 - zugleich Interner Bericht KFA-ZAM-IB-9622 unter dem gleichen Titel SP - 138 EP - 141 ER - TY - JOUR A1 - Schelthoff, Christof A1 - Basermann, Achim A1 - Reichel, Björn T1 - Preconditioned CG methods for sparse matrices on massively parallel machines / Basermann, A. ; Reichel, B. ; Schelthoff, C. JF - Parallel Computing. 23 (1997), H. 3 Y1 - 1997 SN - 0167-8191 SP - 381 EP - 398 ER - TY - JOUR A1 - Schelthoff, Christof A1 - Basermann, Achim T1 - Polynomial Preconditioning for the Conjugate Gradient Method on Massively Parallel Systems JF - Workshop über Parallelverarbeitung : Lessach (Österreich), 26.9.-30.9.1994 / Institut für Informatik, Clausthal-Zellerfeld. Klaus Ecker; Jörg Apsel Y1 - 1995 N1 - Informatik-Bericht ; 95/1 ; Workshop über Parallelverarbeitung ; <13, 1994, Lessach> SP - 150 EP - 167 PB - Inst. für Informatik CY - Clausthal-Zellerfeld ER - TY - JOUR A1 - Sawada, Kazuaki A1 - Nakazawa, Hirokazu A1 - Takenaga, Shoko A1 - Hizawa, Takeshi A1 - Futagawa, Masato A1 - Dasai, Fumihiro A1 - Sakurai, Takashi A1 - Okumura, Koichi A1 - Hattori, Toshiaki A1 - Ishida, Makoto T1 - Multimodal bioimage sensor JF - IEICE transactions on fundamentals of electronics, communidations and computer sciences N2 - To visualize the biochemical distribution two-dimensionally, we invented a solid-state-type ion image sensor that indicates the chemical activity of solutions and cells. The device, which consists of a CCD array covered with a functionalized membrane to detect charge accumulation, is highly sensitive to changes in the concentration and two-dimensional distribution of ions and biomaterials. Y1 - 2014 U6 - http://dx.doi.org/10.1587/transfun.E97.A.726 SN - 0916-8508 (Print) ; 1745-1337 (Online) VL - E97-A (2014) IS - 3 SP - 726 EP - 733 PB - IEICE CY - Tokyo ER -