TY - GEN A1 - Rongen, Heinz A1 - Ziemons, Karl A1 - Schiek, Michael A1 - Tass, Alexander T1 - Vorrichtung zur Messung biomedizinischer Daten eines Probanden und Verfahren zur Simulation des Probanden mit in Echtzeit verarbeiteten Daten T1 - Device for measuring biomedical data from a testee and method for stimulating the testee with data processed in real-time N2 - Die Erfindung betrifft eine Vorrichtung zur Messung biomedizinischer Daten eines Probanden, mit einem Messsystem zur Erhebung der Daten sowie einer ersten Hardware-Komponente zur Aufzeichnung der Daten. In einer Verbindungsleitung zur Übertragung der Daten vom Messsystem zur ersten Hardware-Komponente zur Aufzeichnung der Daten ist erfindungsgemäss ein Mittel zur galvanischen Auftrennung der Daten angeordnet. Auf diese Weise ist wenigstens die Duplizierung der Daten für Datenverarbeitungszwecke gewährleistet. Die auf diese Weise verarbeiteten Daten werden für ein Verfahren zur Echtzeit-Stimulation eines Probanden genutzt. Y1 - 2006 N1 - Auch veröffentlicht als EP2007276 ; US2009069662 ; US8301222 ; JP2009535071 ; WO2007118443 ; AT 533401 SP - 1 EP - 12 ER - TY - GEN A1 - Achten, Richard A1 - Bauer, Andreas A1 - Bertram, Walter A1 - Cremer, Markus A1 - Daemen, Jos A1 - Dehnhardt, Markus A1 - Fleischer, Manfred A1 - Kirchner, Peter A1 - Leyendecker, Marco A1 - Pietrzyk, Uwe A1 - Schmitz, Jakob A1 - Ziemons, Karl A1 - Zilles, Karl T1 - Vorrichtung zum Halten eines lebenden Objektes bei physiologischen Messungen N2 - Die vorliegende Erfindung betrifft eine Vorrichtung zum Halten eines lebenden Objektes bei physiologischen Messungen mit einem Basiselement und Mitteln zum Arretieren des lebenden Objektes, die atraumatische Ohrenhalter sowie ein Mundstück aufweisen, das mit einer Aussparung für die Zähne des Lebewesens versehen ist, mit einem Masseanteil von wenigstens 95% an glasfaserverstärktem Kunststoff. Y1 - 2005 N1 - Patent Anmelder : Forschungszentrum Jülich GmbH SP - 1 EP - 17 ER - TY - RPRT A1 - Albracht, Kirsten A1 - Ritzmann, Ramona A1 - Kramer, Andreas A1 - Meskemper, Joshua A1 - Stäudle, Benjamin A1 - Kümmel, Jacob A1 - Freyler, Katrin A1 - Felsenberg, Dieter A1 - Gruber, Marksu A1 - Gollhofer, Albert A1 - Belavy, Daniel T1 - Vorhaben: Muskelkraftgenerierungsfähigkeit in Mikrogravitation KW - Elektromyographie KW - Bein KW - Extensor KW - Elektrostimulation KW - Raumfahrt Y1 - 2017 U6 - http://dx.doi.org/10.2314/KXP:1670327353 N1 - Förderkennzeichen: BMWi 50WB1428 Öffentlicher Schlussbericht für die Technische Informationsbibliothek der Universität Hannover Berichtszeitraum: 01.09.2014 - 31.01.2017 PB - Deutsche Sporthochschule Köln CY - Klön ER - TY - JOUR A1 - Emons, H. A1 - Glück, O. A1 - Schöning, Michael Josef T1 - Voltohmmetry – An alternative detection principle at ultrathin metal electrodes in solution JF - Chemical and biological sensors and analytical methods : proceedings of the international symposium / Sensor, Physical Electrochemistry, and Organic and Biological Electrochemistry Divisions. Ed.: M. Butler Y1 - 2001 SN - 1-56677-351-2 N1 - International Symposium: Chemical and Biological Sensors and Analytical Methods ; (2 : 2001.) SP - 1 EP - 3 PB - Electrochemical Society CY - Pennington, NJ ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Hüllenkremer, B. A1 - Glück, O. A1 - Lüth, H. A1 - Emons, H. T1 - Voltohmmetry – a novel sensing principle for heavy metal determination in aqueous solutions JF - Sensors and Actuators B. 78 (2001), H. 1-3 Y1 - 2001 SN - 0925-4005 SP - 275 EP - 280 ER - TY - JOUR A1 - Emons, H. A1 - Glück, O. A1 - Hüllenkremer, B. A1 - Schöning, Michael Josef T1 - Voltohmmetry as an alternative detection method at polycrystalline metal film electrodes JF - Electroanalysis. 13 (2001), H. 8-9 Y1 - 2001 SN - 1040-0397 SP - 677 EP - 680 ER - TY - JOUR A1 - Hüllenkremer, B. A1 - Glück, O. A1 - Emons, H. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Voltohmmetrie an polykristallinen Goldelektroden JF - Gesellschaft Mess- und Automatisierungstechnik: Sensoren und Meßsysteme 2000 : Tagung Ludwigsburg, 13. und 14. März 2000 / VDI/VDE-Gesellschaft Meß- und Automatisierungstechnik Y1 - 2000 SN - 3-18-091530-7 N1 - VDI-Berichte; 1530 SP - 45 EP - 54 PB - VDI-Verl. CY - Düsseldorf: ER - TY - JOUR A1 - Emons, H. A1 - Baade, A. A1 - Schöning, Michael Josef T1 - Voltammetric determination of heavy metals in microvolumes of rain water JF - Electroanalysis. 12 (2000), H. 15 Y1 - 2000 SN - 1040-0397 SP - 1171 EP - 1176 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Zang, Werner T1 - Vollautomatische Messung rheologischer Parameter roter Blutzellen JF - Biomedizinische Technik / Biomedical Engineering Y1 - 1990 SN - 0013-5585 VL - 35 IS - S3 SP - 94 EP - 96 ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Sherelkhan, Dinara K. A1 - Lutfor, Afzalunnessa B. A1 - Razzaque, Mohammed S. T1 - Vitamin D and the Host-Gut Microbiome: A Brief Overview JF - Acta Histochemica et Cytochemica N2 - There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression. Y1 - 2020 U6 - http://dx.doi.org/10.1267/ahc.20011 SN - 1347-5800 VL - 53 IS - 3 SP - 33 EP - 42 PB - Japan Society of Histochemistry and Cytochemistry CY - Osaka ER - TY - CHAP A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Sherelkhan, Dinara K. A1 - Razzaque, Mohammed S. T1 - Vitamin D and Phosphate Interactions in Health and Disease T2 - Phosphate Metabolism N2 - Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30–40% and phosphate to nearly 80%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease. KW - Vitamin D KW - PTH KW - Phosphate KW - FGF23 KW - Klotho Y1 - 2022 SN - 978-3-030-91621-3 U6 - http://dx.doi.org/10.1007/978-3-030-91623-7_5 SP - 37 EP - 46 PB - Springer CY - Cham ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Yu, Bing A1 - Isoda, Hiroko A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Visualization of the recovery process of defects in a cultured cell layer by chemical imaging sensor JF - Sensors and Actuators B: Chemical N2 - The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) in the sample. In this study, a novel cell assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the recovery of defects in a cell layer brought into proximity of the sensing surface. A reduced impedance at a defect formed artificially in a cell layer was successfully visualized in a photocurrent image. The cell layer was cultured over two weeks, during which the temporal change of the photocurrent distribution corresponding to the recovery of the defect was observed. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.snb.2016.04.018 SN - 0925-4005 VL - 236 SP - 965 EP - 969 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Hirayama, Yuji A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Visualization of enzymatic reaction in a microfluidic channel using chemical imaging sensor JF - Electrochimica acta Y1 - 2013 SN - 1873-3859 (E-Journal); 0013-4686 (Print) SP - Publ. online PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Bing, Yu A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Visualization of Defects on a Cultured Cell Layer by Utilizing Chemical Imaging Sensor JF - Procedia Engineering N2 - The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) inthe sample. In this study, a novel wound-healing assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the defect of a cell layer brought into proximity of the sensing surface.A reduced impedance inside the defect, which was artificially formed ina cell layer, was successfully visualized in a photocurrent image. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.806 SN - 1877-7058 N1 - Part of special issue "Eurosensors 2015" VL - 120 SP - 936 EP - 939 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Digel, Ilya A1 - Zhubanova, Azhar Ahmetovna A1 - Akimbekov, Nuraly Shardarbekovich T1 - Visual Virology Y1 - 2012 SN - 978-601-247-298-1 N1 - Text kasachisch, russisch, englisch CY - Almaty ER - TY - JOUR A1 - Ullrich, Sebastian A1 - Grottke, Oliver A1 - Rossaint, Rolf A1 - Staat, Manfred A1 - Deserno, Thomas M. A1 - Kuhlen, Torsten T1 - Virtual Needle Simulation with Haptics for Regional Anaesthesia Y1 - 2010 N1 - IEEE Virtual Reality 2010, Workshop on Medical Virtual Environments, Waltham, MA, USA, March 21, 2010 SP - 1 EP - 3 ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Horbach, Andreas A1 - Staat, Manfred A1 - Kowalczyk, Wojciech A1 - Tran, Thanh Ngoc T1 - Virgin passive colon biomechanics and a literature review of active contraction constitutive models JF - Biomechanics N2 - The objective of this paper is to present our findings on the biomechanical aspects of the virgin passive anisotropic hyperelasticity of the porcine colon based on equibiaxial tensile experiments. Firstly, the characterization of the intestine tissues is discussed for a nearly incompressible hyperelastic fiber-reinforced Holzapfel–Gasser–Ogden constitutive model in virgin passive loading conditions. The stability of the evaluated material parameters is checked for the polyconvexity of the adopted strain energy function using positive eigenvalue constraints of the Hessian matrix with MATLAB. The constitutive material description of the intestine with two collagen fibers in the submucosal and muscular layer each has been implemented in the FORTRAN platform of the commercial finite element software LS-DYNA, and two equibiaxial tensile simulations are presented to validate the results with the optical strain images obtained from the experiments. Furthermore, this paper also reviews the existing models of the active smooth muscle cells, but these models have not been computationally studied here. The review part shows that the constitutive models originally developed for the active contraction of skeletal muscle based on Hill’s three-element model, Murphy’s four-state cross-bridge chemical kinetic model and Huxley’s sliding-filament hypothesis, which are mainly used for arteries, are appropriate for numerical contraction numerical analysis of the large intestine. KW - virgin passive KW - strain energy function KW - smooth muscle contraction KW - viscoelasticity KW - damage Y1 - 2022 U6 - http://dx.doi.org/10.3390/biomechanics2020013 SN - 2673-7078 VL - 2 IS - 2 SP - 138 EP - 157 PB - MDPI CY - Basel ER - TY - RPRT A1 - Digel, Ilya A1 - Kayser, Peter T1 - VirEx - Eliminierung von Quarantäne relevanten Viroiden aus Kulturpflanzen Abschlussbericht des Projektes KMU-innovativ-12: Teilprojekt 3 Y1 - 2017 U6 - http://dx.doi.org/10.2314/GBV:1012136345 N1 - Druck-Ausgabe: Schlussbericht für das BMBF-Forschungsvorhaben "VirEx - Eliminierung von Quarantäne relevanten Viroiden aus Kulturpflanzen" Förderkennzeichen BMBF 031A400C PB - Institut für Bioengineering (IfB) der FH Aachen CY - Aachen ER - TY - JOUR A1 - Staat, Manfred T1 - Versagenswahrscheinlichkeit der Primärkreisdruckumschließung eines HTR-Moduls zur Prozeßwärmegewinnung unter Störfallbedingungen bei verschiedenen Versagensmoden Y1 - 1991 N1 - 17. MPA-Seminar : Sicherheit und Verfügbarkeit in der Anlagentechnik mit dem Schwerpunkt Kerntechnik, Stuttgart (1991), 22.1-22.20 ER - TY - JOUR A1 - Staat, Manfred T1 - Versagenswahrscheinlichkeit der Primärkreisdruckumschließung eines HTR-Moduls zur Prozeßwärmegewinnung unter Störfallbedingungen JF - Jahrestagung Kerntechnik '91 / Kerntechnische Gesellschaft e.V. ; Deutsches Atomforum e.V Y1 - 1991 SP - 123 EP - 126 PB - INFORUM CY - Bonn ER -