TY  - JOUR
A1  - Gaigall, Daniel
T1  - On a new approach to the multi-sample goodness-of-fit problem
JF  - Communications in Statistics - Simulation and Computation
N2  - Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.
KW  - Goodness-of-fit test
KW  - Multi-sample problem
KW  - Parametric bootstrap
Y1  - 2019
U6  - https://doi.org/10.1080/03610918.2019.1618472
SN  - 1532-4141
VL  - 53
IS  - 10
SP  - 2971
EP  - 2989
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Meyer, Carolin
A1  - Gaalen, Kerstin van
A1  - Leschinger, Tim
A1  - Scheyerer, Max J.
A1  - Neiss, Wolfram F.
A1  - Staat, Manfred
A1  - Müller, Lars-Peter
A1  - Wegmann, Kilian
T1  - Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement
JF  - BioMed Research International
Y1  - 2019
U6  - https://doi.org/10.1155/2019/9232813
SP  - Article ID 9232813
ER  - 
TY  - JOUR
A1  - Leschinger, Tim
A1  - Birgel, Stefan
A1  - Hackl, Michael
A1  - Staat, Manfred
A1  - Müller, Lars-Peter
A1  - Wegmann, Kilian
T1  - A musculoskeletal shoulder simulation of moment arms and joint reaction forces after medialization of the supraspinatus footprint in rotator cuff repair
JF  - Computer Methods in Biomechanics and Biomedical Engineering
Y1  - 2019
U6  - https://doi.org/10.1080/10255842.2019.1572749
IS  - Early view
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Leschinger, Tim
A1  - Besch, Katharina
A1  - Aydin, Cansu
A1  - Staat, Manfred
A1  - Scaal, Martin
A1  - Müller, Lars-Peter
A1  - Wegmann, Kilian
T1  - Irreparable rotator cuff tears: a biomechanical comparison of superior capsuloligamentous complex reconstruction techniques and an interposition graft technique
JF  - The Orthopaedic Journal of Sports Medicine
Y1  - 2019
U6  - https://doi.org/10.1177/2325967119864590
VL  - 7
IS  - 8
SP  - 1
EP  - 5
ER  - 
TY  - JOUR
A1  - Ortner, Marion
A1  - Hauser, Christine
A1  - Schmaderer, Christoph
A1  - Muggenthaler, Claudia
A1  - Hapfelmeier, Alexander
A1  - Sorg, Christian
A1  - Diehl-Schmid, Janine
A1  - Kurz, Alexander
A1  - Förstl, Hans
A1  - Ikenberg, Benno
A1  - Kotliar, Konstantin
A1  - Holger, Poppert
A1  - Grimmer, Timo
T1  - Decreased vascular pulsatility in Alzheimer’s disease dementia measured by transcranial color-coded duplex sonography
JF  - Neuropsychiatric disease and treatment
N2  - Purpose: Impaired paravascular drainage of β-Amyloid (Aβ) has been proposed as a contributing cause for sporadic Alzheimer’s disease (AD), as decreased cerebral blood vessel pulsatility and subsequently reduced propulsion in this pathway could lead to the accumulation and deposition of Aβ in the brain. Therefore, we hypothesized that there is an increased impairment in pulsatility across AD spectrum.

Patients and Methods: Using transcranial color-coded duplex sonography (TCCS) the resistance and pulsatility index (RI; PI) of the middle cerebral artery (MCA) in healthy controls (HC, n=14) and patients with AD dementia (ADD, n=12) were measured. In a second step, we extended the sample by adding patients with mild cognitive impairment (MCI) stratified by the presence (MCI-AD, n=8) or absence of biomarkers (MCI-nonAD, n=8) indicative for underlying AD pathology, and compared RI and PI across the groups. To control for atherosclerosis as a confounder, we measured the arteriolar-venular-ratio of retinal vessels.

Results: Left and right RI (p=0.020; p=0.027) and left PI (p=0.034) differed between HC and ADD controlled for atherosclerosis with AUCs of 0.776, 0.763, and 0.718, respectively. The RI and PI of MCI-AD tended towards ADD, of MCI-nonAD towards HC, respectively. RIs and PIs were associated with disease severity (p=0.010, p=0.023).

Conclusion: Our results strengthen the hypothesis that impaired pulsatility could cause impaired amyloid clearance from the brain and thereby might contribute to the development of AD. However, further studies considering other factors possibly influencing amyloid clearance as well as larger sample sizes are needed.
Y1  - 2019
U6  - https://doi.org/10.2147/NDT.S225754
SN  - 1178-2021
IS  - 15
SP  - 3487
EP  - 3499
PB  - Dove Medical Press
CY  - Albany, Auckland
ER  -