TY - CHAP A1 - Jabbari, Medisa A1 - Bhattarai, Aroj A1 - Anding, Ralf A1 - Staat, Manfred ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Biomechanical simulation of different prosthetic meshes for repairing uterine/vaginal vault prolapse T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 118 EP - 119 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Suryoputri, Nathania A1 - Ghaderi, Aydin A1 - Linder, Peter A1 - Kotliar, Konstantin A1 - Göttler, Jens A1 - Sorg, Christian A1 - Grimmer, Timo ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Does hemodynamic response function change in Alzheimer disease? T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 92 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Schneider, Oliver A1 - Al Hakim, Taher A1 - Kayser, Peter A1 - Digel, Ilya ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Development and trials of a test chamber for ultrasound-assisted sampling of living cells from solid surfaces T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 96 EP - 97 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Schlemmer, Katharina A1 - Porst, Dariusz A1 - Bassam, Rasha A1 - Artmann, Gerhard A1 - Digel, Ilya ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 100 EP - 101 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Kuhlen, Max A1 - Digel, Ilya ED - Erni, Daniel ED - Fischerauer, Alice ED - Himmel, Jörg ED - Seeger, Thomas ED - Thelen, Klaus T1 - Fluorescence signatures and detection limits of ubiquitous terrestrial bio-compounds T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 102 EP - 103 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - de Honde, Lukas A1 - Porst, Dariusz A1 - Digel, Ilya ED - Fischerauer, Alice T1 - A randomized, observational thermographic study of the neck region before and after a physiotherapeutic intervention T2 - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West Y1 - 2017 SN - 978-3-9814801-9-1 U6 - http://dx.doi.org/10.17185/duepublico/43984 N1 - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 SP - 122 EP - 123 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Meß, Jan-Gerd A1 - Biele, Jens A1 - Seefeldt, Patric A1 - Dachwald, Bernd A1 - Spietz, Peter A1 - Grimm, Christian D. A1 - Spröwitz, Tom A1 - Lange, Caroline A1 - Ulamec, Stephan T1 - Small spacecraft in small solar system body applications T2 - IEEE Aerospace Conference 2017, Big Sky, Montana, USA Y1 - 2017 SN - 978-1-5090-1613-6 U6 - http://dx.doi.org/10.1109/AERO.2017.7943626 SP - 1 EP - 20 ER - TY - CHAP A1 - Tran, Ngoc Trinh A1 - Matthies, Hermann G. A1 - Stavroulakis, Georgios Eleftherios A1 - Staat, Manfred T1 - Direct plastic structural design by chance constrained programming T2 - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK N2 - We propose a stochastic programming method to analyse limit and shakedown of structures under random strength with lognormal distribution. In this investigation a dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit or the shakedown limit. The edge-based smoothed finite element method (ES-FEM) using three-node linear triangular elements is used. Y1 - 2018 ER - TY - CHAP A1 - Jung, Alexander A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Electromechanical model of hiPSC-derived ventricular cardiomyocytes cocultured with fibroblasts T2 - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK N2 - The CellDrum provides an experimental setup to study the mechanical effects of fibroblasts co-cultured with hiPSC-derived ventricular cardiomyocytes. Multi-scale computational models based on the Finite Element Method are developed. Coupled electrical cardiomyocyte-fibroblast models (cell level) are embedded into reaction-diffusion equations (tissue level) which compute the propagation of the action potential in the cardiac tissue. Electromechanical coupling is realised by an excitation-contraction model (cell level) and the active stress arising during contraction is added to the passive stress in the force balance, which determines the tissue displacement (tissue level). Tissue parameters in the model can be identified experimentally to the specific sample. Y1 - 2018 ER - TY - CHAP A1 - Kahmann, Stephanie Lucina A1 - Uschok, Stephan A1 - Wegmann, Kilian A1 - Müller, Lars-P. A1 - Staat, Manfred T1 - Biomechanical multibody model with refined kinematics of the elbow T2 - 6th European Conference on Computational Mechanics (ECCM 6), 7th European Conference on Computational Fluid Dynamics (ECFD 7), 11-15 June 2018, Glasgow, UK N2 - The overall objective of this study is to develop a new external fixator, which closely maps the native kinematics of the elbow to decrease the joint force resulting in reduced rehabilitation time and pain. An experimental setup was designed to determine the native kinematics of the elbow during flexion of cadaveric arms. As a preliminary study, data from literature was used to modify a published biomechanical model for the calculation of the joint and muscle forces. They were compared to the original model and the effect of the kinematic refinement was evaluated. Furthermore, the obtained muscle forces were determined in order to apply them in the experimental setup. The joint forces in the modified model differed slightly from the forces in the original model. The muscle force curves changed particularly for small flexion angles but their magnitude for larger angles was consistent. Y1 - 2018 ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Fernandes, P.R. ED - Tavares, J. M. T1 - Pectopexy to repair vaginal vault prolapse: a finite element approach T2 - Proceedings CMBBE 2018 N2 - The vaginal prolapse after hysterectomy (removal of the uterus) is often associated with the prolapse of the vaginal vault, rectum, bladder, urethra or small bowel. Minimally invasive surgery such as laparoscopic sacrocolpopexy and pectopexy are widely performed for the treatment of the vaginal prolapse with weakly supported vaginal vault after hysterectomy using prosthetic mesh implants to support (or strengthen) lax apical ligaments. Implants of different shape, size and polymers are selected depending on the patient’s anatomy and the surgeon’s preference. In this computational study on pectopexy, DynaMesh®-PRP soft, GYNECARE GYNEMESH® PS Nonabsorbable PROLENE® soft and Ultrapro® are tested in a 3D finite element model of the female pelvic floor. The mesh model is implanted into the extraperitoneal space and sutured to the vaginal stump with a bilateral fixation to the iliopectineal ligament at both sides. Numerical simulations are conducted at rest, after surgery and during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues and prosthetic meshes are modeled as incompressible, isotropic hyperelastic materials. The positions of the organs are calculated with respect to the pubococcygeal line (PCL) for female pelvic floor at rest, after repair and during Valsalva maneuver using the three meshes. Y1 - 2018 N1 - 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 3rd Conference on Imaging and Visualization. CMBBE 2018. 26-29 March 2018, Lisbon, Portugal ER - TY - CHAP A1 - Richter, Charlotte A1 - Braunstein, Bjoern A1 - Stäudle, Benjamin A1 - Attias, Julia A1 - Suess, Alexander A1 - Weber, T. A1 - Rittweger, Joern A1 - Green, David A. A1 - Albracht, Kirsten T1 - In vivo fascicle length of the gastrocnemius muscle during walking in simulated martian gravity using two different body weight support devices T2 - 23rd Annual Congress of the European College of Sport Science, Dublin, Irland Y1 - 2018 ER - TY - CHAP A1 - Behbahani, Mehdi T1 - An Experimental Study of Thrombocyte Reactions in Response to Biomaterial Surfaces and Varying Shear Stress T2 - Proceedings of the International Conference on Biomedical Engineering and Systems Prague, Czech Republic, August 14-15, 2014 Y1 - 2014 SP - Paper 125 ER - TY - CHAP A1 - Behbahani, Mehdi A1 - Rible, Sebastian A1 - Moulinec, Charles A1 - Fournier, Yvan A1 - Nicolai, Mike A1 - Crosetto, Paolo T1 - Simulation of the FDA Centrifugal Blood Pump Using High Performance Computing T2 - World Academy of Science, Engineering and Technology International Journal of Mechanical and Mechatronics Engineering Y1 - 2015 VL - 9 IS - 5 ER - TY - CHAP A1 - Baader, Fabian A1 - Reiswich, M. A1 - Bartsch, M. A1 - Keller, D. A1 - Tiede, E. A1 - Keck, G. A1 - Demircian, A. A1 - Friedrich, M. A1 - Dachwald, Bernd A1 - Schüller, K. A1 - Lehmann, R. A1 - Chojetzki, R. A1 - Durand, C. A1 - Rapp, L. A1 - Kowalski, Julia A1 - Förstner, R. T1 - VIPER - Student research on extraterrestrical ice penetration technology T2 - Proceedings of the 2nd Symposium on Space Educational Activities N2 - Recent analysis of scientific data from Cassini and earth-based observations gave evidence for a global ocean under a surrounding solid ice shell on Saturn's moon Enceladus. Images of Enceladus' South Pole showed several fissures in the ice shell with plumes constantly exhausting frozen water particles, building up the E-Ring, one of the outer rings of Saturn. In this southern region of Enceladus, the ice shell is considered to be as thin as 2 km, about an order of magnitude thinner than on the rest of the moon. Under the ice shell, there is a global ocean consisting of liquid water. Scientists are discussing different approaches the possibilities of taking samples of water, i.e. by melting through the ice using a melting probe. FH Aachen UAS developed a prototype of maneuverable melting probe which can navigate through the ice that has already been tested successfully in a terrestrial environment. This means no atmosphere and or ambient pressure, low ice temperatures of around 100 to 150K (near the South Pole) and a very low gravity of 0,114 m/s^2 or 1100 μg. Two of these influencing measures are about to be investigated at FH Aachen UAS in 2017, low ice temperature and low ambient pressure below the triple point of water. Low gravity cannot be easily simulated inside a large experiment chamber, though. Numerical simulations of the melting process at RWTH Aachen however are showing a gravity dependence of melting behavior. Considering this aspect, VIPER provides a link between large-scale experimental simulations at FH Aachen UAS and numerical simulations at RWTH Aachen. To analyze the melting process, about 90 seconds of experiment time in reduced gravity and low ambient pressure is provided by the REXUS rocket. In this time frame, the melting speed and contact force between ice and probes are measured, as well as heating power and a two-dimensional array of ice temperatures. Additionally, visual and infrared cameras are used to observe the melting process. Y1 - 2018 SP - 1 EP - 6 ER - TY - CHAP A1 - Hunker, Jan A1 - Jung, Alexander A1 - Goßmann, Matthias A1 - Linder, Peter A1 - Staat, Manfred ED - Staat, Manfred ED - Erni, Daniel T1 - Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool. Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 7 EP - 8 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Raman, Aravind Hariharan A1 - Jung, Alexander A1 - Horváth, András A1 - Becker, Nadine A1 - Staat, Manfred ED - Staat, Manfred ED - Erni, Daniel T1 - Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich). Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 10 EP - 11 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Azar, Fouad A1 - Digel, Ilya ED - Staat, Manfred ED - Erni, Daniel T1 - Utilization of fluorescence spectroscopy and neural networks in clinical analysis T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Fluorescence topography of human urine in combination with learning algorithms can provide a variant pattern recognition method in analytical clinical chemistry and, eventually, diagnosis. Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 40 EP - 41 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Zingsheim, Jonas A1 - Grimmer, Timo A1 - Ortner, Marion A1 - Schmaderer, Christoph A1 - Hauser, Christine A1 - Kotliar, Konstantin ED - Staat, Manfred ED - Erni, Daniel T1 - Recognition of subjects with mild cognitive impairment (MCI) by the use of retinal arterial vessels. T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 36 EP - 37 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Blum, Yannik A1 - Albanna, Walid A1 - Benninghaus, Anne A1 - Kotliar, Konstantin ED - Staat, Manfred ED - Erni, Daniel T1 - Vasomotion in retinal vessels of patients presenting post hemorrhagic hydrocephalus following subarachnoid hemorrhage T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Clearance of blood components and fluid drainage play a crucial role in subarachnoid hemorrhage (SAH) and post hemorrhagic hydrocephalus (PHH). With the involvement of interstitial fluid (ISF) and cerebrospinal fluid (CSF), two pathways for the clearance of fluid and solutes in the brain are proposed. Starting at the level of capillaries, flow of ISF follows along the basement membranes in the walls of cerebral arteries out of the parenchyma to drain into the lymphatics and CSF [1]–[3]. Conversely, it is shown that CSF enters the parenchyma between glial and pial basement membranes of penetrating arteries [4]–[6]. Nevertheless, the involved structures and the contribution of either flow pathway to fluid balance between the subarachnoid space and interstitial space remains controversial. Low frequency oscillations in vascular tone are referred to as vasomotion and corresponding vasomotion waves are modeled as the driving force for flow of ISF out of the parenchyma [7]. Retinal vessel analysis (RVA) allows non-invasive measurement of retinal vessel vasomotion with respect to diameter changes [8]. Thus, the aim of the study is to investigate vasomotion in RVA signals of SAH and PHH patients. Y1 - 2019 SN - 978-3-940402-22-6 U6 - http://dx.doi.org/10.17185/duepublico/48750 SP - 38 EP - 39 PB - Universität Duisburg-Essen CY - Duisburg ER -