TY  - CHAP
A1  - Rabner, Arthur
A1  - Shacham, Yosi
T1  - A concept for a sensitive micro total analysis system for high throughput fluorescence imaging
N2  - This paper discusses possible methods for on-chip fluorescent imaging for integrated bio-sensors. The integration of optical and electro-optical accessories, according to suggested methods, can improve the performance of fluorescence imaging. It can boost the signal to background ratio by a few orders of magnitudes in comparison to conventional discrete setups. The methods that are present in this paper are oriented towards building reproducible arrays for high-throughput micro total analysis systems (µTAS). The first method relates to side illumination of the fluorescent material placed into microcompartments of the lab-on-chip. Its significance is in high utilization of excitation energy for low concentration of fluorescent material. The utilization of a transparent µLED chip, for the second method, allows the placement of the excitation light sources on the same optical axis with emission detector, such that the excitation and emission rays are directed controversly. The third method presents a spatial filtering of the excitation background.
KW  - Biosensor
KW  - Fluorescence
KW  - imaging
KW  - lab-on-chip
KW  - fluidic
KW  - lenslet array
KW  - LED chip
KW  - image sensor
KW  - biosensor
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1456
ER  - 
TY  - CHAP
A1  - Förster, Arnold
A1  - Stock, Jürgen
A1  - Montanari, Simone
A1  - Lepsa, Mihail Ion
A1  - Lüth, Hans
T1  - Fabrication and characterisation of GaAs Gunn Diode Chips for applications at 77 GHz in automotive industry
N2  - GaAs-based Gunn diodes with graded AlGaAs hot electron injector heterostructures have been developed under the special needs in automotive applications. The fabrication of the Gunn diode chips was based on total substrate removal and processing of integrated Au heat sinks. Especially, the thermal and RF behavior of the diodes have been analyzed by DC, impedance and S-parameter measurements. The electrical investigations have revealed the functionality of the hot electron injector. An optimized layer structure could fulfill the requirements in adaptive cruise control (ACC) systems at 77 GHz with typical output power between 50 and 90 mW.
KW  - Biosensor
KW  - Gunn diode
KW  - microwave generation
KW  - GaAs hot electron injector
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1462
ER  - 
TY  - CHAP
A1  - Pijanowska, Dorota G.
A1  - Remiszewska, Elzbieta
A1  - Pederzolli, Cecilia
A1  - Lunelli, Lorenzo
A1  - Vendano, Michele
A1  - Canteri, Roberto
A1  - Dudzinski, Konrad
A1  - Kruk, Jerzy
A1  - Torbicz, Wladyslaw
T1  - Surface modification for microreactor fabrication
N2  - In this paper, methods of surface modification of different supports, i.e. glass and polymeric beads for enzyme immobilisation are described. The developed method of enzyme immobilisation is based on Schiff’s base formation between the amino groups on the enzyme surface and the aldehyde groups on the chemically modified surface of the supports. The surface of silicon modified by APTS and GOPS with immobilised enzyme was characterised by atomic force microscopy (AFM), time-of-flight secondary ion mass spectroscopy (ToF-SIMS) and infrared spectroscopy (FTIR). The supports with immobilised enzyme (urease) were also tested in combination with microreactors fabricated in silicon and Perspex, operating in a flow-through system. For microreactors filled with urease immobilised on glass beads (Sigma) and on polymeric beads (PAN), a very high and stable signal (pH change) was obtained. The developed method of urease immobilisation can be stated to be very effective.
KW  - Biosensor
KW  - Microreactors
KW  - surface modification
KW  - enzyme immobilisation
KW  - lab-on-a-chip
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1480
ER  - 
TY  - CHAP
A1  - Bukhari, Syed Faisal Ahmed
A1  - Yang, Wuqiang
T1  - Multi-interface level sensors and new development in monitoring and control of oil separators
N2  - In the oil industry, huge saving may be made if suitable multi-interface level measurement systems are employed for effectively monitoring crude oil separators and efficient control of their operation. A number of techniques, e.g. externally mounted displacers, differential pressure transmitters and capacitance rod devices, have been developed to measure the separation process with gas, oil, water and other components. Because of the unavailability of suitable multi-interface level measurement systems, oil separators are currently operated by the trial-and-error approach. In this paper some conventional techniques, which have been used for level measurement in industry, and new development are discussed.
KW  - Biosensor
KW  - Level sensor
KW  - multi-interface measurement
KW  - electrical capacitance tomography
KW  - ECT
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1498
ER  - 
TY  - CHAP
A1  - Tymecki, Lukasz
A1  - Glab, Stanislaw
A1  - Koncki, Robert
T1  - Miniaturized, planar ion-selective electrodes fabricated by means of thick-film  technology
N2  - Various planar technologies are employed for developing solid-state sensors having low cost, small size and high reproducibility; thin- and thick-film technologies are most suitable for such productions. Screen-printing is especially suitable due to its simplicity, low-cost, high reproducibility and efficiency in large-scale production. This technology enables the deposition of a thick layer and allows precise pattern control. Moreover, this is a highly economic technology, saving large amounts of the used inks. In the course of repetitions of the film-deposition procedure there is no waste of material due to additivity of this thick-film technology. Finally, the thick films can be easily and quickly deposited on inexpensive substrates. In this contribution, thick-film ion-selective electrodes based on ionophores as well as crystalline ion-selective materials dedicated for potentiometric measurements are demonstrated. Analytical parameters of these sensors are comparable with those reported for conventional potentiometric electrodes. All mentioned thick-film strip electrodes have been totally fabricated in only one, fully automated thickfilm technology, without any additional manual, chemical or electrochemical steps. In all cases simple, inexpensive, commercially available materials, i.e. flexible, plastic substrates and easily cured polymer-based pastes were used.
KW  - Biosensor
KW  - Potentiometry
KW  - thick-film technology
KW  - screen-printing
KW  - ion-selective electrodes
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1506
ER  - 
TY  - CHAP
A1  - Kraft, Bodo
A1  - Retkowitz, Daniel
T1  - Rule-Dependencies for Visual Knowledge Specification in Conceptual Design
N2  - In: Proc. of the 11th Intl. Conf. on Computing in Civil and Building Engineering (ICCCBE-XI) ed. Hugues Rivard, Montreal, Canada, Seite 1-12, ACSE (CD-ROM), 2006 Currently, the conceptual design phase is not adequately supported by any CAD tool. Neither the support while elaborating conceptual sketches, nor the automatic proof of correctness with respect to effective restrictions is currently provided by any commercial tool. To enable domain experts to store the common as well as their personal domain knowledge, we develop a visual language for knowledge formalization. In this paper, a major extension to the already existing concepts is introduced. The possibility to define rule dependencies extends the expressiveness of the knowledge definition language and contributes to the usability of our approach.
KW  - CAD
KW  - CAD
KW  - Bauingenieurwesen
KW  - CAD
KW  - civil engineering
Y1  - 2006
ER  - 
TY  - JOUR
A1  - Kämper, Klaus-Peter
A1  - Picard, A.
A1  - Schütze, A.
A1  - Wallach, D.
T1  - Adopting the Foundry Concept of Semiconductor Fabrication on Educational Schemes and the Virtual Technology Lab (VTL). Picard, A.; Kämper, K.-P.; Schütze, A.; Wallach, D.; Walter, T.
JF  - Mst-News (2006)
Y1  - 2006
SN  - 0948-3128
SP  - 15, 16
EP  - u. 35
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Moro, D.
A1  - Ferreti, A.
A1  - Colautti, P.
T1  - The new articulated twin mini TEPC
JF  - Annual Report  2006 / Istituto Nazionale di Fisica Nucleare <Frascati> / Laboratori Nazionali <Legnaro>
Y1  - 2006
SP  - 273
CY  - Legnaro
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Kim, Jihoe
A1  - Darley, Daniel
A1  - Buckel, Wolfgang
T1  - Characterization of (R)-2-hydroxyisocaproate dehydrogenase and a family III coenzyme A transferase involved in reduction of L-leucine to isocaproate by Clostridium difficile / Kim, J. ; Darley, D. ; Selmer, T. ; Buckel, W.
JF  - Applied and Environmental Microbiology. 72 (2006), H. 9
Y1  - 2006
SN  - 0099-2240
N1  - PMID: 16957230
SP  - 6062
EP  - 6069
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Yu, Lihua
A1  - Blaser, Martin
A1  - Andrei, Paula I.
T1  - 4-Hydroxyphenylacetate decarboxylases: properties of a novel subclass of glycyl radical enzyme systems / Yu, L. ; Blaser, M. ; Andrei, PI. ; Pierik, AJ. Selmer, T.
JF  - Biochemistry. 31 (2006), H. 45
Y1  - 2006
N1  - PMID: 16878993
SP  - 9584
EP  - 9592
ER  - 
TY  - JOUR
A1  - Streun, M.
A1  - Chavan, U.
A1  - Lame, H.
A1  - Parl, C.
A1  - Müller-Veggian, Mattea
A1  - Ziemons, Karl
T1  - Treating the Gain Non-Uniformity of Multi Channel PMTs by Channel-Specific Trigger Levels
JF  - 2006 IEEE Nuclear Science Symposium Conference Record, Vol. 2.
Y1  - 2006
SN  - 1082-3654
SP  - 1301
EP  - 1304
CY  - San Diego, CA
ER  - 
TY  - BOOK
A1  - Mautner, Karin
T1  - Numerical treatment of the Black-Scholes variational inequality in computational finance
Y1  - 2006
N1  - Humboldt-Univ., Diss
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Chwallek, Constanze
A1  - Felden, Birgit
T1  - RatingCheck : Wertschöpfungskette / Chwallek, Constanze ; Felden, Birgit
Y1  - 2006
PB  - Deutscher Sparkassen Verlag
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Pes, Michaela
A1  - Osen, Wolfram
A1  - Dürst, Matthias
T1  - An improved rearranged Human Papillomavirus Type 16 E7 DNA vaccine candidate (HPV-16 E7SH) induces an E7 wildtype-specific T cell response / Öhlschläger, Peter ; Pes, Michaela ; Osen, Wolfram ; Dürst, Matthias ; Schneider, Achim ; Gissmann, Lutz ; Kaufman
JF  - Vaccine. 24 (2006), H. 15
Y1  - 2006
SN  - 0264-410X
SP  - 2880
EP  - 2893
ER  - 
TY  - JOUR
A1  - Hartung, Frank
A1  - Schieder, Andreas
A1  - Kampmann, Markus
A1  - Vorwerk, Marc
T1  - Network Supported Media Delivery in Ambient Networks (Netzwerkunterstützte Medienverteilung) / Schieder, Andreas ; Kampmann, Markus ; Hartung, Frank ; Vorwerk, Marc ; Rembarz, René
JF  - it - Information Technology . 48 (2006), H. 5
Y1  - 2006
SN  - 1611-2776
N1  - in der Bereichsbibliothek Eupener Str. unter der Signatur 23 Z 376 vorhanden
SP  - 264
EP  - 273
ER  - 
TY  - JOUR
A1  - Hartung, Frank
A1  - Niebert, Norbert
A1  - Schieder, Andreas
A1  - Rembarz, René
T1  - Advances in network-supported media delivery in next-generation mobile systems / Hartung, Frank  ; Niebert, Norbert ; Schieder, Andreas ; Rembarz, René ; Schmid, Stefan ; Eggert, Lars
JF  - IEEE Communications Magazine. 44 (2006), H. 8
Y1  - 2006
SN  - 0163-6804
SP  - 82
EP  - 89
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Koshitz, I. N.
A1  - Svetlowa, O. V.
A1  - Zaseeva, M. V.
T1  - Physiological principles of hypotensive therapy of open-angle glaucoma during presbyopic period. Part II Promising algorithms of practical sparing applications / Koshitz, I. N. ; Svetlova, O. V. ; Zaseeva, M. V. ; Shuhaev, S. V. ; Makarov, F. N. ; Kotliar
JF  - Glaukoma (2006)
Y1  - 2006
N1  - Original in Russisch
SP  - 51
EP  - 70
PB  - -
ER  - 
TY  - CHAP
A1  - Uibel, Thomas
A1  - Blaß, Hans Joachim
T1  - Load Carrying Capacity of Joints with Dowel Type Fasteners in Solid Wood Panels
T2  - Proceedings. CIB-W18 Meeting 2006, Florence, Italy 2006
Y1  - 2006
SN  - 0945-6996
N1  - Paper 39-7-5
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Mosset, J.-B.
A1  - Devroede, O.
A1  - Krieguer, M.
A1  - Rey, M.
A1  - Vieira, J.-M.
A1  - Jung, J. H.
A1  - Kuntner, C.
A1  - Streun, M.
A1  - Ziemons, Karl
A1  - Auffray, E.
A1  - Sempere-Roldan, P.
A1  - Lecoq, P.
A1  - Bruyndonckx, P.
A1  - Loude, J.-F.
A1  - Tavernier, S.
A1  - Morcel, C.
T1  - Development of an optimized LSO/LuYAP phoswich detector head for the Lausanne ClearPET demonstrator
JF  - IEEE Transactions on Nuclear Science
N2  - This paper describes the LSO/LuYAP phoswich detector head developed for the ClearPET small animal PET scanner demonstrator that is under construction in Lausanne within the Crystal Clear Collaboration. The detector head consists of a dual layer of 8×8 LSO and LuYAP crystal arrays coupled to a multi-anode photomultiplier tube (Hamamatsu R7600-M64). Equalistion of the LSO/LuYAP light collection is obtained through partial attenuation of the LSO scintillation light using a thin aluminum deposit of 20-35 nm on LSO and appropriate temperature regulation of the phoswich head between 30°C to 60°C. At 511keV, typical FWHM energy resolutions of the pixels of a phoswich head amounts to (28±2)% for LSO and (25±2)% for LuYAP. The LSO versus LuYAP crystal identification efficiency is better than 98%. Six detector modules have been mounted on a rotating gantry. Axial and tangential spatial resolutions were measured up to 4 cm from the scanner axis and compared to Monte Carlo simulations using GATE. FWHM spatial resolution ranges from 1.3 mm on axis to 2.6 mm at 4 cm from the axis.
Y1  - 2006
SN  - 0018-9499
VL  - 53
IS  - 1
SP  - 25
EP  - 29
ER  - 
TY  - JOUR
A1  - Streun, M.
A1  - Brandenburg, G.
A1  - Larue, H.
A1  - Parl, C.
A1  - Ziemons, Karl
T1  - The data acquisition system of ClearPET neuro - a small animal PET scanner
JF  - IEEE Transactions on Nuclear Science
N2  - The Crystal Clear Collaboration has developed a modular system for a small animal PET scanner (ClearPET). The modularity allows the assembly of scanners of different sizes and characteristics in order to satisfy the specific needs of the individual member institutions. The system performs depth of interaction detection by using a phoswich arrangement combining LSO and LuYAP scintillators which are coupled to Multichannel Photomultipliers (PMTs). For each PMT a free running 40 MHz ADC digitizes the signal and the complete scintillation pulse is sampled by an FPGA and sent with 20 MB/s to a PC for preprocessing. The pulse provides information about the gamma energy and the scintillator material which identifies the interaction layer. Furthermore, the exact pulse starting time is obtained from the sampled data. This is important as no hardware coincidence detection is implemented. All single events are recorded and coincidences are identified by software. The system in Jülich (ClearPET Neuro) is equipped with 10240 crystals on 80 PMTs. The paper will present an overview of the data acquisition system.
Y1  - 2006
SN  - 0018-9499
VL  - 53
IS  - 3
SP  - 700
EP  - 703
ER  -