TY  - JOUR
A1  - Winckler, Silvia
A1  - Krueger, Rolf
A1  - Schnitzler, Thomas
A1  - Zang, Werner
A1  - Fischer, Rainer
A1  - Biselli, Manfred
T1  - A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach
JF  - Bioprocess and biosystems engineering
N2  - Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.
Y1  - 2014
U6  - https://doi.org/10.1007/s00449-013-1062-8
SN  - 1615-7591 (Print) 1615-7605 (Online)
VL  - 37
IS  - 5
SP  - 901
EP  - 912
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Wilson, Thomas L
A1  - Blome, Hans-Joachim
A1  - LaFave, Norman
T1  - Astrophysical Cosmology Using a Lunar Ligo
JF  - Engineering, construction, and operations in space V : proceedings of the Fifth International Conference on Space '96, Albuquerque, New Mexico, June 1-6, 1996 / sponsored by Aerospace Division of the American Society of Civil Engineers ... [et al.]; edite
Y1  - 1996
SN  - 0-7844-0177-2
SP  - 861
EP  - 863
PB  - The Society
CY  - New York
ER  - 
TY  - JOUR
A1  - Wilson, T. L.
A1  - Blome, Hans-Joachim
T1  - The Pioneer anomaly and a rotating Gödel universe
JF  - Advances in Space Research
Y1  - 2009
SN  - 0273-1177
VL  - 44
IS  - 11
SP  - 1345
EP  - 1353
ER  - 
TY  - JOUR
A1  - Wilson, Ian D.
A1  - Wilson, Claire E.
A1  - Scheer, Nico
A1  - Dickie, A.P.
A1  - Schreiter, K.
A1  - Wilson, E. M.
A1  - Riley, R. J.
A1  - Wehr, R.
A1  - Bial, J.
T1  - The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
JF  - Biochemical pharmacology
Y1  - 2017
U6  - https://doi.org/10.1016/j.bcp.2017.03.015
SN  - 1873-2968
VL  - Volume 135
SP  - 139
EP  - 150
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wilson, C. E.
A1  - Dickie, A. P.
A1  - Schreiter, K.
A1  - Wehr, R.
A1  - Wilson, E. M.
A1  - Bial, J.
A1  - Scheer, Nico
A1  - Wilson, I. D.
A1  - Riley, R. J.
T1  - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
JF  - Archives of Toxicology
N2  - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.
Y1  - 2018
U6  - https://doi.org/10.1007/s00204-018-2212-1
SN  - 1432-0738
VL  - 92
IS  - 6
SP  - 1953
EP  - 1967
PB  - Springer
ER  - 
TY  - JOUR
A1  - Wilming, Anja
A1  - Begemann, Jens
A1  - Kuhne, Stefan
A1  - Regestein, Lars
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Maurer, Karl-Heinz
A1  - Büchs, Jochen
T1  - Metabolic studies of γ-polyglutamic acid production in Bacillus licheniformis by small-scale continuous cultivations
JF  - Biochemical engineering journal
Y1  - 2013
SN  - 1873-295X (E-Journal); 1369-703X (Print)
VL  - Vol. 73
SP  - 29
EP  - 37
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - Newly found plans for the chapel of the Holy Shroud
JF  - Studi Piemontesi
Y1  - 2017
SN  - 0392-7261
VL  - XLVI
IS  - 1
SP  - 75
EP  - 85
ER  - 
TY  - CHAP
A1  - Wilke, Thomas
ED  - Merlotti, Andrea
T1  - Planning Process of the Di Castellamonte’s Chapel of the Holy Shroud
T2  - Carlo e Amedeo di Castellamonte : 1571-1683, ingegneri e architetti per i duchi di Savoia
Y1  - 2016
SN  - 978-88-98229-57-4
N1  - Architettura e potere ; 4
SP  - 141
EP  - 152
PB  - Campisano editore
CY  - Rom
ER  - 
TY  - JOUR
A1  - Wild, Dominik
A1  - Schrezenmeier, Johannes
A1  - Czupalla, Markus
A1  - Förstner, Roger
T1  - Thermal Characterization of additive manufactured Integral Structures for Phase Change Applications
JF  - 2020 International Conference on Environmental Systems
N2  - “Infused Thermal Solutions” (ITS) introduces a method for passive thermal control to stabilize structural components thermally without active heating and cooling systems, by using phase change material (PCM) in combination with lattice – both embedded into an additive manufactured integral structure. The technology is currently under development. This paper presents the results of the thermal property measurements performed on additive manufactured ITS breadboards. Within the breadboard campaigns key characteristics of the additive manufactured specimens were derived: Mechanical parameters: specimen impermeability, minimum wall thickness, lattice structure, subsequent heat treatment. Thermal properties: thermo-optical surface properties of the additive manufactured raw material, thermal conductivity and specific heat capacity measurements. As a conclusion the paper introduces an overview of potential ITS hardware applications, expected to increase the thermal performance.
Y1  - 2020
PB  - Texas Tech University
ER  - 
TY  - CHAP
A1  - Wild, Dominik
A1  - Czupalla, Markus
A1  - Förstner, Roger
T1  - Modeling, prediction and test of additive manufactured integral structures with embedded lattice and phase change material applying Infused Thermal Solutions (ITS)
T2  - ICES104: Advances in Thermal Control Technology
N2  - Infused Thermal Solutions (ITS) introduces a method for passive thermal control to stabilize structural components thermally without active heating and cooling systems, but with phase change material (PCM) for thermal energy storage (TES), in combination with lattice - both embedded in additive manufactured functional structures. In this ITS follow-on paper a thermal model approach and associated predictions are presented, related on the ITS functional breadboards developed at FH Aachen. Predictive TES by PCM is provided by a specially developed ITS PCM subroutine, which is applicable in ESATAN. The subroutine is based on the latent heat storage (LHS) method to numerically embed thermo-physical PCM behavior. Furthermore, a modeling approach is introduced to numerically consider the virtual PCM/lattice nodes within the macro-encapsulated PCM voids of the double wall ITS design. Related on these virtual nodes, in-plane and out-of-plane conductive links are defined. The recent additive manufactured ITS breadboard series are thermally cycled in the thermal vacuum chamber, both with and without embedded PCM. Related on breadboard hardware tests, measurement results are compared with predictions and are subsequently correlated. The results of specific simulations and measurements are presented. Recent predictive results of star tracker analyses are also presented in ICES-2021-106, based on this ITS PCM subroutine.
KW  - latent heat
KW  - thermo-physical
KW  - lattice
KW  - ESATAN
KW  - subroutine
KW  - PCM
KW  - ITS
Y1  - 2021
N1  - 50th International Conference on Environmental Systems, 12-15 July 2021, held virtually
PB  - Texas Tech University
CY  - Lubbock, Tex.
ER  - 
TY  - JOUR
A1  - Wiesen, Sebastian
A1  - Tippkötter, Nils
A1  - Muffler, Kai
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - Adsorption of fatty acids to layered double hydroxides in aqueous systems
JF  - Adsorption
N2  - Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L−1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32−.
Y1  - 2015
VL  - 21
IS  - 6-7
SP  - 459
EP  - 466
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Wiesen, Patrick
A1  - Engemann, Heiko
A1  - Limpert, Nicolas
A1  - Kallweit, Stephan
T1  - Learning by Doing - Mobile Robotics in the FH Aachen ROS Summer School
T2  - European Robotics Forum 2018, TRROS18 Workshop
Y1  - 2018
SP  - 47
EP  - 58
ER  - 
TY  - CHAP
A1  - Wiegner, Jonas
A1  - Volker, Hanno
A1  - Mainz, Fabian
A1  - Backes, Andreas
A1  - Löken, Michael
A1  - Hüning, Felix
T1  - Wiegand-effect-powered wireless IoT sensor node
T2  - ITG-Fb. 303: Sensoren und Messsysteme
N2  - In this article we describe an Internet-of-Things sensing device with a wireless interface which is powered by the oftenoverlooked harvesting method of the Wiegand effect. The sensor can determine position, temperature or other resistively measurable quantities and can transmit the data via an ultra-low power ultra-wideband (UWB) data transmitter. With this approach we can energy-self-sufficiently acquire, process, and wirelessly transmit data in a pulsed operation. A proof-of-concept system was built up to prove the feasibility of the approach. The energy consumption of the system is analyzed and traced back in detail to the individual components, compared to the generated energy and processed to identify further optimization options. Based on the proof-of-concept, an application demonstrator was developed. Finally, we point out possible use cases.
Y1  - 2022
SN  - 978-3-8007-5835-7
N1  - Sensoren und Messsysteme - 21. ITG/GMA-Fachtagung, 10.05.2022 - 11.05.2022 in Nürnberg
SP  - 255
EP  - 260
PB  - VDE Verlag GmbH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wiegner, Jonas
A1  - Volker, Hanno
A1  - Mainz, Fabian
A1  - Backes, Andreas
A1  - Loeken, Michael
A1  - Hüning, Felix
T1  - Energy analysis of a wireless sensor node powered by a Wiegand sensor
JF  - Journal of Sensors and Sensor Systems (JSSS)
N2  - This article describes an Internet of things (IoT) sensing device with a wireless interface which is powered by the energy-harvesting method of the Wiegand effect. The Wiegand effect, in contrast to continuous sources like photovoltaic or thermal harvesters, provides small amounts of energy discontinuously in pulsed mode. To enable an energy-self-sufficient operation of the sensing device with this pulsed energy source, the output energy of the Wiegand generator is maximized. This energy is used to power up the system and to acquire and process data like position, temperature or other resistively measurable quantities as well as transmit these data via an ultra-low-power ultra-wideband (UWB) data transmitter. A proof-of-concept system was built to prove the feasibility of the approach. The energy consumption of the system during start-up was analysed, traced back in detail to the individual components, compared to the generated energy and processed to identify further optimization options. Based on the proof of concept, an application prototype was developed.
Y1  - 2023
U6  - https://doi.org/10.5194/jsss-12-85-2023
SN  - 2194-878X
N1  - Corresponding author: Felix Hüning
VL  - 12
IS  - 1
SP  - 85
EP  - 92
PB  - Copernicus Publ.
CY  - Göttingen
ER  - 
TY  - GEN
A1  - Wiegner, J.
A1  - Volker, H.
A1  - Mainz, F.
A1  - Backes, A.
A1  - Löken, M.
A1  - Hüning, Felix
T1  - Wiegand-Effect-Powered Wireless IT Sensor Node
N2  - With the growing interest in small distributed sensors for the “Internet of Things”, more attention is being paid to energy harvesting techologies. Reducing or eliminating the need for external power sources or batteries make devices more self-sufficient, more reliable, and reduces maintenance requirements. The Wiegand effect is a proven technology for harvesting small amounts of electrical power from mechanical motion.
Y1  - 2022
N1  - PSMA International Energy Harvesting Workshop ~ 5-7 April 2022, Raleigh, NC, USA
ER  - 
TY  - JOUR
A1  - Wiegand, Sandra
A1  - Voigt, Birgit
A1  - Albrecht, Dirk
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Hecker, Michael
A1  - Daniel, Rolf
A1  - Liesegang, Heiko
T1  - Fermentation stage-dependent adaptations of Bacillus licheniformis during enzyme production
JF  - Microbial Cell Factories
Y1  - 2013
U6  - https://doi.org/10.1186/1475-2859-12-120
SN  - 1475-2859
VL  - 12
SP  - 120
PB  - Biomed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Wiegand, Sandra
A1  - Dietrich, Sascha
A1  - Hertel, Robert
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Volland, Sonja
A1  - Daniel, Rolf
A1  - Liesegang, Heiko
T1  - RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation
JF  - BMC genomics
Y1  - 2013
SN  - 1471-2164
VL  - Vol. 14
SP  - 667
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Whitehead, Mark
A1  - Öhlschläger, Peter
A1  - Almajhdi, Fahad N.
A1  - Alloza, Leonor
A1  - Marzábal, Pablo
A1  - Meyers, Ann E.
A1  - Hitzeroth, Inga I.
A1  - Rybicki, Edward P.
T1  - Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice
JF  - BMC cancer
Y1  - 2014
U6  - https://doi.org/10.1186/1471-2407-14-367
SN  - 1471-2407
IS  - 14:367
SP  - 1
EP  - 15
PB  - BioMed Central
CY  - London
ER  - 
TY  - CHAP
A1  - Weßling, Matthias
T1  - Leadership Perspectives: Research Findings, Theories, Practical Experiences
N2  - Leadership Perspectives: Research Findings, Theories, Practical Experiences: Results of Leadership Research and exemplarily application cases show the perspectives and consequences for leadership practice and the following requirements for executives in future.
N2  - Leadership Perspectives: Research Findings, Theories, Practical Experiences: Bisherige Ergebnisse der betriebswirtschaftlichen Führungsforschung und exemplarische Anwendungsbeispiele der Führungspraxis, sowie die Schlußfolgerungen für die Perspektiven der betrieblichen Mitarbeiterführung sowie die sich daraus ergebenden Anforderungen an zukünftige Führungskräfte.
KW  - Leadership
KW  - Führung
KW  - Führungsansätze
KW  - Leadership
KW  - Self-Leadership
KW  - Leadership Approaches
KW  - Skill Assessment
KW  - Leadership Theories
Y1  - 2007
ER  - 
TY  - CHAP
A1  - Weßling, Matthias
T1  - Motivation and Leadership - The Reiss-Profile of the 16 Basic Desires: Research results and managerial applications
N2  - Recent Results of the scientific Reiss-Profile (16 basic desires) due to the concept of Prof. Dr. Steven Reiss (State University Ohio, U.S.A.), supplemented by the comparative analysis of empirical motivational profiles of european executives of various companies.
N2  - Neuere Forschungsergebnisse des wissenschaftlichen Reiss-Profils der 16 Lebensmotive nach Prof. Dr. Steven Reiss (State University Ohio, U.S.A.) und die Möglichkeiten und Grenzen ihrer Umsetzung in der betrieblichen Führungspraxis unter Integration der vergleichenden Analyse und Interpretation empirisch erhobener Motivprofile einzelner europäischer Führungskräfte.
KW  - Motivation
KW  - Leadership
KW  - Motivation
KW  - Führung
KW  - Motivation
KW  - Leadership
Y1  - 2007
ER  -