TY  - JOUR
A1  - Inagaki, Akiko
A1  - Sleddens-Linkels, Esther
A1  - Wassenaar, Evelyne
A1  - Ooms, Marja
A1  - Cappellen, Wiggert A. van
A1  - Hoeijmakers, Jan H. J.
A1  - Seibler, Jost
A1  - Vogt, Thomas F.
A1  - Shin, Myung K.
A1  - Grootegoed, J. Anton
A1  - Baarends, Willy M.
T1  - Meiotic functions of RAD18
JF  - Journal of Cell Science
Y1  - 2011
U6  - https://doi.org/10.1242/jcs.081968
SN  - 1477-9137
VL  - 124
IS  - 16
SP  - 2837
EP  - 2850
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Raab, Monika
A1  - Kappel, Sven
A1  - Krämer, Andrea
A1  - Sanhaji, Mourad
A1  - Matthess, Yves
A1  - Kurunci-Csacsko, Elisabeth
A1  - Calzada-Wack, Julia
A1  - Rathkolb, Birgit
A1  - Rosman, Jan
A1  - Adler, Thure
A1  - Busch, Dirk H.
A1  - Esposito, Irene
A1  - Fuchs, Helmut
A1  - Gailus-Durner, Valérie
A1  - Klingenspor, Martin
A1  - Wolf, Eckhard
A1  - Sänger, Nicole
A1  - Prinz, Florian
A1  - Hrabe de Angelis, Martin
A1  - Seibler, Jost
A1  - Yuan, Juping
A1  - Bergmann, Martin
A1  - Knecht, Rainald
A1  - Kreft, Bertolt
A1  - Strebhardt, Klaus
T1  - Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
JF  - Nature Communications
Y1  - 2011
U6  - https://doi.org/10.1038/ncomms1395
SN  - 2041-1723
VL  - 2
IS  - 395
SP  - 1
EP  - 11
PB  - Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Hasegawa, Maki
A1  - Kapelyukh, Yury
A1  - Tahara, Harunobu
A1  - Seibler, Jost
A1  - Rode, Anja
A1  - Krueger, Sylvia
A1  - Lee, Dongtao N.
A1  - Wolf, C. Roland
A1  - Scheer, Nico
T1  - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line
JF  - Molecular Pharmacology
Y1  - 2011
U6  - https://doi.org/10.1124/mol.111.071845
SN  - 1521-0111
VL  - 80
IS  - 33
SP  - 518
EP  - 528
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - https://doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - JOUR
A1  - Bongaerts, Johannes
A1  - Esser, Simon
A1  - Lorbach, Volker
A1  - Al-Momani, Lóay
A1  - Müller, Michael A.
A1  - Franke, Dirk
A1  - Grondal, Christoph
A1  - Kurutsch, Anja
A1  - Bujnicki, Robert
A1  - Takors, Ralf
A1  - Raeven, Leon
A1  - Wubbolts, Marcel
A1  - Bovenberg, Roel
A1  - Nieger, Martin
A1  - Schürmann, Melanie
A1  - Trachtmann, Natalie
A1  - Kozak, Stefan
A1  - Sprenger, Georg A.
A1  - Müller, Michael
T1  - Diversity-oriented production of metabolites derived from chorismate and their use in organic synthesis
JF  - Angewandte Chemie International Edition
Y1  - 2011
SN  - 1521-3773 (E-Journal); 0570-0833 (Print); 1433-7851 (Print)
VL  - Vol. 50
IS  - Iss. 34
SP  - 7781
EP  - 7786
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bung, Daniel Bernhard
T1  - Developing flow in skimming flow regime on embankment stepped spillways
JF  - Journal of hydraulic research
Y1  - 2011
SN  - 1814-2079 (E-Journal); 0022-1686 (Print)
VL  - Vol. 49
IS  - Iss. 5
SP  - 639
EP  - 648
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Marais, Stephen
A1  - Potgieter, Anet
A1  - Steinbauer, Gerald
T1  - RoboCup Junior: A vehicle for S&T education in Africa?
Y1  - 2011
SN  - 978-1-61284-992-8
N1  - AFRICON, 2011
SP  - 1
EP  - 6
PB  - IEEE
CY  - New York
ER  - 
TY  - CHAP
A1  - Schiffer, Stefan
A1  - Ferrein, Alexander
A1  - Lakemeyer, Gerhard
T1  - Fuzzy representations and control for domestic service robots in Golog
T2  - Intelligent robotics and applications : 4th International conference, ICIRA 2011, Aachen, Germany, December 6-8, 2011, proceedings, part I. (Lecture notes in computer science ; 7102)
Y1  - 2011
SN  - 978-3-642-25486-4
SP  - 241
EP  - 250
ER  - 
TY  - CHAP
A1  - Ahmed, H.
A1  - Schlenkhoff, A.
A1  - Bung, Daniel Bernhard
T1  - Hydrodynamic characteristics of vertical slotted wall breakwaters
T2  - Balance and uncertainty - water in a changing world :  proceedings of the 34th IAHR world congress ; 33rd Hydrology and Water Resources Symposium ; 10th Conference on Hydraulics in Water Engineering ; 26 June - 1 July 2011, Brisbane, Australia
Y1  - 2011
SN  - 978-0-85825-868-6
SP  - 1179
EP  - 1186
ER  - 
TY  - JOUR
A1  - Sieker, Tim
A1  - Neuner, Andreas
A1  - Dimitrova, Darina
A1  - Tippkötter, Nils
A1  - Muffler, Kai
A1  - Bart, Hans-Jörg
A1  - Heinzle, Elmar
A1  - Ulber, Roland
T1  - Ethanol production from grass silage by simultaneous pretreatment, saccharification and fermentation: First steps in the process development
JF  - Engineering in Life Sciences
N2  - Grass silage provides a great potential as renewable feedstock. Two fractions of the grass silage, a press juice and the fiber fraction, were evaluated for their possible use for bioethanol production. Direct production of ethanol from press juice is not possible due to high concentrations of organic acids. For the fiber fraction, alkaline peroxide or enzymatic pretreatment was used, which removes the phenolic acids in the cell wall. In this study, we demonstrate the possibility to integrate the enzymatic pretreatment with a simultaneous saccharification and fermentation to achieve ethanol production from grass silage in a one-process step. Achieved yields were about 53 g ethanol per kg silage with the alkaline peroxide pretreatment and 91 g/kg with the enzymatic pretreatment at concentrations of 8.5 and 14.6 g/L, respectively. Furthermore, it was shown that additional supplementation of the fermentation medium with vitamins, trace elements and nutrient salts is not necessary when the press juice is directly used in the fermentation step.
Y1  - 2011
U6  - https://doi.org/10.1002/elsc.201000160
N1  - Special Issue "Bioprocess‐oriented plant design"
VL  - 11
IS  - 4
SP  - 436
EP  - 442
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Warerkar, Shashikant
A1  - Schmitz, Stefan
A1  - Göttsche, Joachim
A1  - Hoffschmidt, Bernhard
A1  - Reißel, Martin
A1  - Tamme, Rainer
T1  - Air-Sand Heat Exchanger for High-Temperature Storage
JF  - Journal of Solar Energy Engineering. 133 (2011), H. 2
Y1  - 2011
SN  - 0199-6231
N1  - 7 pages
SP  - 021010
PB  - ASME
CY  - New York
ER  - 
TY  - JOUR
A1  - Doorschodt, B. M.
A1  - Schreinemachers, M. C. J. M.
A1  - Behbahani, Mehdi
A1  - Florquin, S.
A1  - Weis, J.
A1  - Staat, Manfred
A1  - Tolba, R. H.
T1  - Hypothermic machine perfusion of kidney grafts: which pressure is preferred
JF  - Annals of Biomedical Engineering. 39 (2011), H. 3
Y1  - 2011
SN  - 1573-9686
SP  - 1051
EP  - 1059
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Ohndorf, Andreas
A1  - Dachwald, Bernd
A1  - Seboldt, Wolfgang
A1  - Schartner, Karl-Heinz
T1  - Flight times to the heliopause using a combination of solar and radioisotope electric propulsion
T2  - 32nd International Electric Propulsion Conference
N2  - We investigate the interplanetary flight of a low-thrust space probe to the heliopause,located at a distance of about 200 AU from the Sun. Our goal was to reach this distance within the 25 years postulated by ESA for such a mission (which is less ambitious than the 15-year goal set by NASA). Contrary to solar sail concepts and combinations of allistic and electrically propelled flight legs, we have investigated whether the set flight time limit could also be kept with a combination of solar-electric propulsion and a second, RTG-powered upper stage. The used ion engine type was the RIT-22 for the first stage and the RIT-10 for the second stage. Trajectory optimization was carried out with the low-thrust optimization program InTrance, which implements the method of Evolutionary Neurocontrol,using Artificial Neural Networks for spacecraft steering and Evolutionary Algorithms to optimize the Neural Networks’ parameter set. Based on a parameter space study, in which the number of thrust units, the unit’s specific impulse, and the relative size of the solar power generator were varied, we have chosen one configuration as reference. The transfer time of this reference configuration was 29.6 years and the fastest one, which is technically
more challenging, still required 28.3 years. As all flight times of this parameter study were longer than 25 years, we further shortened the transfer time by applying a launcher-provided hyperbolic excess energy up to 49 km2/s2. The resulting minimal flight time for the reference configuration was then 27.8 years. The following, more precise optimization to a launch with the European Ariane 5 ECA rocket reduced the transfer time to 27.5 years. This is the fastest mission design of our study that is flexible enough to allow a launch every
year. The inclusion of a fly-by at Jupiter finally resulted in a flight time of 23.8 years,which is below the set transfer-time limit. However, compared to the 27.5-year transfer,this mission design has a significantly reduced launch window and mission flexibility if the
escape direction is restricted to the heliosphere’s “nose".
KW  - low-thrust trajectory optimization
KW  - heliosphere
KW  - ion propulsion
Y1  - 2011
N1  - IEPC-2011-051
32nd International Electric Propulsion Conference,September 11–15, 2011
Wiesbaden, Germany
SP  - 1
EP  - 12
ER  - 
TY  - JOUR
A1  - Scholz, Christina
A1  - Romagnoli, Daniele
A1  - Dachwald, Bernd
A1  - Theil, Stephan
T1  - Performance analysis of an attitude control system for solar sails using sliding masses
JF  - Advances in Space Research
Y1  - 2011
SN  - 0273-1177
VL  - 48
IS  - 11
SP  - 1822
EP  - 1835
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Baumann, Torsten
A1  - Teixeira Boura, Cristiano José
A1  - Göttsche, Joachim
A1  - Hoffschmidt, Bernhard
A1  - Schmitz, Stefan
A1  - Zunft, Stefan
T1  - Air-sand heat exchanger: materials and flow properties
T2  - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain
Y1  - 2011
CY  - Granada
ER  - 
TY  - CHAP
A1  - Fricke, Barbara
A1  - Ziolko, C.
A1  - Anthrakidis, Anette
A1  - Alexopoulos, Spiros
A1  - Hoffschmidt, Bernhard
A1  - Dillig, M.
A1  - Giese, F.
T1  - InnoSol - life cycle analysis of solar power tower plants
T2  - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain
Y1  - 2011
CY  - Granada
ER  - 
TY  - JOUR
A1  - Kleefeld, Andreas
A1  - Reißel, Martin
T1  - The Levenberg–Marquardt method applied to a parameter estimation problem arising from electrical resistivity tomography
JF  - Applied Mathematics and Computation
Y1  - 2011
SN  - 0096-3003
VL  - 217
IS  - 9
SP  - 4490
EP  - 4501
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Becker, Jörg
A1  - Bergener, Philipp
A1  - Breuker, Dominic
A1  - Delfmann, Patrick
A1  - Eggert, Mathias
T1  - An Efficient Business Process Compliance Checking Approach
T2  - Governance and Sustainability in Information Systems. Managing the Transfer and Diffusion of IT : IFIP WG 8.6 International Working Conference, Hamburg, Germany, September 22-24, 2011. Proceedings
Y1  - 2011
U6  - https://doi.org/10.1007/978-3-642-24148-2_19
SP  - 282
EP  - 287
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Nguyen-Xuan, H.
A1  - Rabczuk, T.
A1  - Nguyen-Thoi, T.
A1  - Tran, Thanh Ngoc
A1  - Nguyen-Thanh, N.
T1  - Computation of limit and shakedown loads using a node-based smoothed finite element method
JF  - International Journal for Numerical Methods in Engineering
N2  - This paper presents a novel numerical procedure for computing limit and shakedown loads of structures using a node-based smoothed FEM in combination with a primal–dual algorithm. An associated primal–dual form based on the von Mises yield criterion is adopted. The primal-dual algorithm together with a Newton-like iteration are then used to solve this associated primal–dual form to determine simultaneously both approximate upper and quasi-lower bounds of the plastic collapse limit and the shakedown limit. The present formulation uses only linear approximations and its implementation into finite element programs is quite simple. Several numerical examples are given to show the reliability, accuracy, and generality of the present formulation compared with other available methods.
Y1  - 2011
U6  - https://doi.org/10.1002/nme.3317
SN  - 1097-0207
VL  - 90
IS  - 3
SP  - 287
EP  - 310
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Rens, Gavin
A1  - Meyer, Thomas
A1  - Lakemeyer, Gerhard
T1  - A Logic for Specifying Partially Observable Stochastic Domains / Rens, Gavin ; Meyer, Thomas ; Ferrein, Alexander ; Lakemeyer, Gerhard
JF  - Proceedings of the Ninth International Workshop pn non-Monotonic Reasoning, Action and Change (NRAC`11)
Y1  - 2011
N1  - Technical Report RMIT-TR-11-02
SP  - 15
EP  - 22
ER  -