TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Corvinus, Florian M.
A1  - Orth, Carina
A1  - Moriggl, Richard
T1  - Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth / Corvinus, Florian, Moriggl, Richard ; Tsareva, Svetlana A. ; Wagner, Stefan ; Pfitzner, Edith B. ; Baus, Daniela ; Kaufmann, Roland : Huber, Luka
JF  - Neoplasia. 7 (2005), H. 6
Y1  - 2005
SN  - 1476-5586
SP  - 545
EP  - 555
ER  - 
TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Quetting, Michael
A1  - Alvarez, Gerardo
A1  - Dürst, Matthias
A1  - Gissmann, Lutz
A1  - Kaufmann, Andreas M.
T1  - Enhancement of immunogenicity of a therapeutic cervical cancer DNA-based vaccine by co-application of sequence-optimized genetic adjuvants
JF  - International Journal of Cancer
Y1  - 2009
SN  - 1097-0215
VL  - 125
IS  - 1
SP  - 189
EP  - 198
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Oosterhuis, Koen
A1  - Öhlschläger, Peter
A1  - Berg, Joost H. van den
A1  - Toebes, Mireille
A1  - Gomez, Raquel
A1  - Schumacher, Ton N.
A1  - Haanen, John B.
T1  - Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7
JF  - International Journal of Cancer
Y1  - 2011
SN  - 1097-0215
VL  - 129
IS  - 2
SP  - 397
EP  - 406
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Spies, Elmar
A1  - Alvarez, Gerardo
A1  - Quetting, Michael
A1  - Groettrup, Marcus
T1  - The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA
JF  - International Journal of Cancer. 128 (2011), H. 2
Y1  - 2011
SN  - 1097-0215
SP  - 473
EP  - 481
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Immel, Timo A.
A1  - Groth, Ulrich
A1  - Huhn, Thomas
A1  - Öhlschläger, Peter
T1  - Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice
JF  - PLoS ONE
N2  - The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
Y1  - 2011
U6  - https://doi.org/10.1371/journal.pone.0017869
VL  - 6
IS  - 3
PB  - Plos
CY  - San Francisco, California, US
ER  - 
TY  - JOUR
A1  - Leurs, Ulrike
A1  - Mezo, Gabor
A1  - Öhlschläger, Peter
A1  - Orban, Erika
A1  - Marquard, Andrea
A1  - Manea, Marilena
T1  - Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety
JF  - Peptide Science
N2  - Bioconjugates containing the GnRH-III hormone decapeptide as a targeting moiety are able to deliver chemotherapeutic agents specifically to cancer cells expressing GnRH receptors, thereby increasing their local efficacy while limiting the peripheral toxicity. However, the number of GnRH receptors on cancer cells is limited and they desensitize under continuous hormone treatment. A possible approach to increase the receptor mediated tumor targeting and consequently the cytostatic effect of the bioconjugates would be the attachment of more than one chemotherapeutic agent to one GnRH-III molecule. Here we report on the design, synthesis and biochemical characterization of multifunctional bioconjugates containing GnRH-III as a targeting moiety and daunorubicin as a chemotherapeutic agent. Two different drug design approaches were pursued. The first one was based on the bifunctional [4Lys]-GnRH-III (Glp-His-Trp-Lys-His-Asp-Trp-Lys-Pro-Gly-NH2) containing two lysine residues in positions 4 and 8, whose ϵ-amino groups were used for the coupling of daunorubicin. In the second drug design, the native GnRH-III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2) was used as a scaffold; an additional lysine residue was coupled to the ϵ-amino group of 8Lys in order to generate two free amino groups available for conjugation of daunorubicin. The in vitro stability/degradation of all synthesized compounds was investigated in human serum, as well as in the presence of rat liver lysosomal homogenate. Their cellular uptake was determined on human breast cancer cells and the cytostatic effect was evaluated on human breast, colon and prostate cancer cell lines. Compared with a monofunctional compound, both drug design approaches resulted in multifunctional bioconjugates with increased cytostatic effect.
Y1  - 2012
U6  - https://doi.org/10.1002/bip.21640
SN  - 1097-0282
VL  - 98
IS  - 1
SP  - 1
EP  - 10
PB  - Wiley
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Manea, Marilena
A1  - Leurs, Ulrike
A1  - Orban, Erika
A1  - Baranyai, Zsuzsa
A1  - Öhlschläger, Peter
A1  - Marquardt, Andreas
A1  - Schulcz, Akos
A1  - Tejeda, Miguel
T1  - Enhanced Enzymatic Stability and Antitumor Activity of Daunorubicin-GnRH-III Bioconjugates Modified in Position 4
JF  - Bioconjugate Chemistry
Y1  - 2011
SN  - 1520-4812
VL  - 22
IS  - 7
SP  - 1320
EP  - 1329
PB  - ACS
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Spiess, Elmar
A1  - Wilfried, Reichardt
A1  - Alvarez, Gerardo
A1  - Gottrup, Marcus
A1  - Öhlschläger, Peter
T1  - An Artificial PAP Gene Breaks Self-tolerance and Promotes Tumor Regression in the TRAMP Model for Prostate Carcinoma
JF  - Molecular Therapy
Y1  - 2011
SN  - 1525-0016
VL  - 20
IS  - 3
SP  - 555
EP  - 564
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Grinsven, Bart van
A1  - Bon, Natalie vanden
A1  - Strauven, Hannelore
A1  - Grieten, Lars
A1  - Murib, Mohammed
A1  - Jiménez Monroy, Kathia L.
A1  - Janssens, Stoffel D.
A1  - Haenen, Ken
A1  - Schöning, Michael Josef
A1  - Vermeeren, Veronique
A1  - Ameloot, Marcel
A1  - Michiels, Luc
A1  - Thoelen, Ronald
A1  - Ceuninck, Ward de
A1  - Wagner, Patrick
T1  - Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA.
JF  - ACS Nano
N2  - In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA.
Y1  - 2012
U6  - https://doi.org/10.1021/nn300147e
SN  - 1936-086X
VL  - 6
IS  - 3
SP  - 2712
EP  - 2721
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Arida, Hassan A.
A1  - Al-haddad, Ameera
A1  - Schöning, Michael Josef
T1  - New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode
JF  - International Journal of Electrochemical Science. 6 (2011), H. 9
Y1  - 2011
SN  - 1452-3981
SP  - 3858
EP  - 3867
ER  - 
TY  - CHAP
A1  - Fredebeul-Krein, Markus
A1  - Steingröver, Markus
T1  - Wholesale Broadband Access to IPTV in an NGA environment : how to deal with it from a regulatory perspective?
Y1  - 2012
N1  - Regional ITS Conference of the international Telecommunications Society , February 22-24, 2012 New Delhi, India
SP  - 1
EP  - 16
ER  - 
TY  - CHAP
A1  - Bohrn, U.
A1  - Stütz, E.
A1  - Fleischer, M.
A1  - Schöning, Michael Josef
A1  - Wagner, P.
ED  - Abdelghani, Adnane
ED  - Schöning, Michael Josef
T1  - Towards a paradigm change – mammalian cells as sensitive biosensor layers for the detection of unexpected toxic substances in air
T2  - Nanoscale Science and Technology (NS&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012
Y1  - 2012
SP  - 44
EP  - 44
ER  - 
TY  - BOOK
A1  - Havermann, Marc
T1  - PIV measurements in shock tunnels : PivNet 2, Final Workshop, Göttingen, 07. - 08.09.2006
Y1  - 2006
N1  - Publication / Institut Franco-Allemand de Recherches de Saint Louis ; 644
PB  - ISL
CY  - Saint-Louis
ER  - 
TY  - BOOK
A1  - Havermann, Marc
T1  - PIV measurements of compressible vortex rings generated by a shock tube : 13th International Symposium on Applications of Laser Techniques to Fluid Mechanics, Lisbon, PT, 26-29.06.2006; axe de recherches 2.14 / Haertig, J.; Rey, C.; Havermann, M. Institut Franco-Allemand de Recherches de Saint-Louis
Y1  - 2006
N1  - Publication / Institut Franco-Allemand de Recherches de Saint Louis ; 645
PB  - ISL
CY  - Saint-Louis
ER  - 
TY  - BOOK
A1  - Havermann, Marc
A1  - Seiler, Friedrich
T1  - Boundary layer influence on supersonic jet cross flow interaction in hypersonic flow : DGLR/STAB-Fachsymposium Strömungsmechanik 2004, Bremer Innovations- und Technologiezentrum (BITZ), Bremen, FRG, 16. - 18. November 2004 / Havermann, M.; Seiler, F. Institut Franco-Allemand de Recherches de Saint-Louis
Y1  - 2004
N1  - Publication / Institut Franco-Allemand de Recherches de Saint-Louis ; 658
PB  - ISL
CY  - Saint-Louis
ER  - 
TY  - BOOK
A1  - Havermann, Marc
T1  - Shock tunnel measurement of the interaction amplification factor for a hot gas side jet in a supersonic cross-flow : 24th International Symposium on Shock Waves, Beijing, China, July 11 - 16, 2004 / Institut Franco-Allemand de Recherches de Saint-Louis. Havermann, M. ...
Y1  - 2004
N1  - Publication / Institut Franco-Allemand de Recherches de Saint-Louis ; 642
PB  - ISL
CY  - Saint-Louis
ER  - 
TY  - BOOK
A1  - Havermann, Marc
A1  - Ende, Herrybert
A1  - Schwenzer, Michael
T1  - Shock tunnel study on the interaction of a lateral jet with a supersonic cross flow : West East High-Speed Flow Field Conference, Marseille, France, April 22 - 26, 2002; axe de recherches 2.14 / Havermann, M.; Ende, H.; Schwenzer, M. Institut Franco-Allemand de Recherches de Saint-Louis
Y1  - 2002
N1  - Publication / Institut Franco-Allemand de Recherches de Saint-Louis ; 620
PB  - ISL
CY  - Saint-Louis
ER  - 
TY  - BOOK
A1  - Havermann, Marc
A1  - Haertig, J.
A1  - Rey, C.
A1  - George, A.
T1  - Application of particle image velocimetry to high-speed supersonic flows in a shock tunnel : 11th International Symposium on Applications of Laser Techniques to Fluid Mechanics, Lisbon, Portugal, July 8 - 11, 2002; Schwerpunkt 0 / Institut Franco-Allemand de Recherches de Saint-Louis. Havermann, M. ...
Y1  - 2002
N1  - Publication / Institut Franco-Allemand de Recherches de Saint-Louis ; 640
PB  - ISL
CY  - Saint-Louis
ER  - 
TY  - BOOK
A1  - Havermann, Marc
T1  - Particle image velocimetry (PIV) applied to high-speed shock tunnel flows / 23rd International Symposium on Shock Waves, Fort Worth/TX, USA, July 22 - 27, 2001. Institut Franco-Allemand de Recherches de Saint-Louis. Havermann, M. ...
Y1  - 2001
N1  - International Symposium on Shock Waves 23, 2001, Fort Worth, Tex.; Publication / Institut Franco-Allemand de Recherches de Saint-Louis ; 640
PB  - ISL
CY  - Saint-Louis
ER  - 
TY  - JOUR
A1  - Lettini, Antonio
A1  - Havermann, Marc
A1  - Guidetti, Marco
A1  - Fornaciari, Andrea
T1  - Improved functionalities and energy saving potential on mobile machines combining electronics with flow sharing valve and variable displacement pump
JF  - IFK 7, 7th International Fluid Power Conference, Efficiency through Fluid Power, 7. Internationales Fluidtechnisches Kolloquium, Workshop Proceedings, Vol. 3, Aachen, DE, 22.-24. Mar, 2010
Y1  - 2010
SN  - 978-3-940565-92-1
N1  - IFK, 7, Internationales Fluidtechnisches Kolloquium, 7., Aachen, DE, 2010-03-22 - 2010-03-24
SP  - 103
EP  - 114
PB  - -
ER  -