TY  - JOUR
A1  - Seifarth, Volker
A1  - Schehl, D.
A1  - Linder, Peter
A1  - Gossmann, Matthias
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Porst, Dariusz
A1  - Preiß, C.
A1  - Kayser, Peter
A1  - Pack, O.
A1  - Temiz Artmann, Aysegül
T1  - Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds
N2  - The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.
KW  - Tissue Engineering
KW  - Bioreaktor
KW  - Organkultur
KW  - Harnleiter
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Zhubanova, Azhar A.
A1  - Aknazarov, S. K.
A1  - Mansurov, Zulkhair
A1  - Digel, Ilya
A1  - Kozhalakova, A. A.
A1  - Akimbekov, Nuraly S.
A1  - O'Heras, Carlos
A1  - Tazhibayeva, S.
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials
N2  - Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.
KW  - Kohlenstofffaser
KW  - Lipopolysaccharide
KW  - nanostrukturierte carbonisierte Pflanzenteile
KW  - lipopolysaccharides
KW  - nanostructured carbonized plant parts
Y1  - 2010
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Ballmann, J.
T1  - Computation of impacts on elastic solids by methods of bicharacteristics
JF  - Computational Mechanics '88 : theory and applications ; proceedings of the International Conference on Computational Engineering Science April 10-14, 1988, Atlanta, GA, USA ; vol. 2
N2  - Shock waves, explosions, impacts or cavitation bubble collapses may generate stress waves in solids causing cracks or unexpected dammage due to focussing, physical nonlinearity or interaction with existing cracks. There is a growing interest in wave propagation, which poses many novel problems to experimentalists and theorists.
KW  - Bicharakteristikenverfahren
KW  - Elastizität
KW  - elastic solids
KW  - bicharacteristics
Y1  - 1988
SP  - 1719
EP  - 1722
ER  - 
TY  - JOUR
A1  - Akimbekov, Nuraly S.
A1  - Mansurov, Zulkhair
A1  - Jandosov, J.
A1  - Digel, Ilya
A1  - Gossmann, Matthias
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
A1  - Zhubanova, Azhar A.
T1  - Wound healing activity of carbonized rice husk
N2  - The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.
KW  - Wundheilung
KW  - Epithel
KW  - Fibroblast
KW  - carbonized rice husk
KW  - wound healing
KW  - epithelization
KW  - human dermal fibroblasts
Y1  - 2013
PB  - Trans Tech Publications, Switzerland
CY  - Bäch
ER  - 
TY  - JOUR
A1  - Kraft, Bodo
A1  - Nagl, Manfred
T1  - Visual Knowledge Specification for Conceptual Design: Definition and Tool Support
N2  - In: Advanced Engineering Informatics. Vol 21, Issue 1, 2007, Pages 67-83 http://dx.doi.org/10.1016/j.aei.2006.10.001 eds. J.C. Kunz, I.F.C. Smith and T. Tomiyama, Elsevier, Seite 1-22 Current CAD tools are not able to support the conceptual design phase, and none of them provides a consistency analysis for sketches produced by architects. This phase is fundamental and crucial for the whole design and construction process of a building. To give architects a better support, we developed a CAD tool for conceptual design and a knowledge specification tool. The knowledge is specific to one class of buildings and it can be reused. Based on a dynamic and domain-specific knowledge ontology, different types of design rules formalize this knowledge in a graph-based form. An expressive visual language provides a user-friendly, human readable representation. Finally, a consistency analysis tool enables conceptual designs to be checked against this formal conceptual knowledge. In this article, we concentrate on the knowledge specification part. For that, we introduce the concepts and usage of a novel visual language and describe its semantics. To demonstrate the usability of our approach, two graph-based visual tools for knowledge specification and conceptual design are explained.
KW  - CAD
KW  - CAD
KW  - Bauingenieurwesen
KW  - CAD
KW  - civil engineering
Y1  - 2007
ER  - 
TY  - JOUR
A1  - Zhubanova, Azhar A.
A1  - Digel, Ilya
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology
N2  - The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.
KW  - Clusterion
KW  - Raumluft
KW  - Luftreiniger
KW  - Plasmacluster ion technology
KW  - Air purification
Y1  - 2007
ER  - 
TY  - JOUR
A1  - Bogoyavlenskiy, A. P.
A1  - Digel, Ilya
A1  - Berezin, V. E.
T1  - Assessment of dot-blot ELISA sensitivity on membrane sorbent using various peroxidase substrates
N2  - The sensitivity of the peroxidase reaction in dot-blot ELISA significantly depends on the substrate. The highest sensitivity is observed using benzidine and diamine- phenol combinations as the substrates due to the reaction of the coupled oxidation (NADI)
KW  - Enzyme-linked immunosorbent assay
KW  - Peroxidase
KW  - ELISA
KW  - phenols
KW  - naphtols
KW  - aromatic amines
Y1  - 1997
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Heitzer, M.
T1  - Structural Reliability Analysis of Elasto-Plastic Structures
JF  - Safety and reliability : proceedings of ESREL '99, the Tenth European Conference on Safety and Reliability, Munich-Garching, Germany, 13 - 17 September 1999 / Schuëller, G. I.; Kafka, P. [eds]
Y1  - 1999
SN  - 90-5809-109-0
SP  - 513
EP  - 518
PB  - Balkema
CY  - Rotterdam
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Fiorini, G. L.
A1  - Lensa, W. von
A1  - Burgazzi, L.
T1  - Reliability Methods for Passive Safety Functions
JF  - Proceedings of the SMiRT 14 Post Conference Seminar No 18 on Passive Safety Features in Nuclear Installations
Y1  - 1997
CY  - Pisa
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Heitzer, M.
T1  - Limit and Shakedown Analysis for Plastic Safety of Complex Structures
JF  - Transactions of the 14th International Conference on Structural Dynamics in Reactor Technology (SMiRT-14) / Livolant, M. [ed]
Y1  - 1997
N1  - Vol. B, Paper B02/2
SP  - 33
EP  - 40
CY  - Lyon
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Heitzer, M.
T1  - Limit and Shakedown Analysis Using a General Purpose Finite Element Code
JF  - Proceedings of NAFEMS World Congress '97 on Design, Simulation & Optimisation : reliability & applicability of computational methods ; Stuttgart, Germany, 9 - 11 April 1997
Y1  - 1997
SN  - 1-87437-620-4
SP  - 522
EP  - 533
PB  - NAFEMS
CY  - Glasgow
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Problems and Chances for Probabilistic Fracture Mechanics in the Analysis of Steel Pressure Boundary Reliability
JF  - Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in Jülich, 21-24 November 1994
Y1  - 1996
N1  - IAEA-TECDOC-920 ; Onlinezugriff erfolgt auf die überarb. Ausg. 2006
SP  - 43
EP  - 55
CY  - Vienna
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Sensitivity of and Influences on the Reliability of an HTR-Module Primary Circuit Pressure Boundary
JF  - Transactions of the 12th International Conference on Structural Mechanics in Reactor Technology (SMiRT-12) / Kussmaul, K. [ed]
Y1  - 1993
SN  - 0-444-81515-5
N1  - Vol. M, Paper MG10/2
SP  - 147
EP  - 152
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Reliability of the Primary Circuit Pressure Boundary of an HTR-Module under Accident Conditions
JF  - Safety and reliability assessment : an integral approach ; ESREL'93 ; proceedings of the European Safety and Reliability Conference, Munich, Germany, May 10th - 12th 1993 / Kafka, P. [ed]
Y1  - 1993
SN  - 0-444-81561-9
SP  - 331
EP  - 342
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kurowski, A.
A1  - Schultze, J.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Micro- and nanopatterning of sensor chips by means of macroporous silicon.
JF  - Sensors and Actuators B. 83 (2002), H. 1-3
Y1  - 2002
SN  - 0925-4005
N1  - Selected Papers from TRANSDUCERS '01 EUROSENSORS XV
SP  - 123
EP  - 128
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Steinbauer, Gerald
A1  - Vassos, Stavros
T1  - Action-Based Imperative Programming with YAGI
N2  - Many tasks for autonomous agents or robots are best described by a specification of the environment and a specification of the available actions the agent or robot can perform. Combining such a specification with the possibility to imperatively program a robot or agent is what we call the actionbased imperative programming. One of the most successful such approaches is Golog. In this paper, we draft a proposal for a new robot programming language YAGI, which is based on the action-based imperative programming paradigm. Our goal is to design a small, portable stand-alone YAGI interpreter. We combine the benefits of a principled domain specification with a clean, small and simple programming language, which does not exploit any side-effects from the implementation language. We discuss general requirements of action-based programming languages and outline YAGI, our action-based language approach which particularly aims at embeddability.
Y1  - 2012
N1  - Cognitive Robotics
AAAI Technical Report WS-12-06
SP  - 24
EP  - 31
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Furuichi, K.
A1  - Levichev, S.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Lithium sensor based on the laser scanning semiconductor transducer
JF  - Analytica Chimica Acta. 459 (2002), H. 1
Y1  - 2002
SN  - 0378-4304
SP  - 1
EP  - 9
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Schultze, J. W.
A1  - Lüth, H.
T1  - Field-effect based multifunctional hybrid sensor module for the determination of both (bio-)chemical and physical paramters
JF  - Proceedings of SPIE. 4576 (2002)
Y1  - 2002
SP  - 149
EP  - 159
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Berndsen, Lars
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Novel concepts for flow-rate and flow-direction determination by means of pH-sensitive ISFETs
JF  - Proceedings of SPIE. 4560 (2001)
Y1  - 2001
SP  - 19
EP  - 27
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schroth, Peter
A1  - Lüth, Hans
A1  - Hummel, Hans E.
A1  - Schütz, Stefan
T1  - Insect chemoreceptors coupled to silicon transistors as innovative biosensors
JF  - Proceedings of SPIE. 4205 (2001)
Y1  - 2001
SP  - 152
EP  - 162
ER  -