TY - CHAP A1 - Koch, Claudia A1 - Poghossian, Arshak A1 - Wege, Christina A1 - Schöning, Michael Josef ED - Wege, Christina T1 - TMV-Based Adapter Templates for Enhanced Enzyme Loading in Biosensor Applications T2 - Virus-Derived Nanoparticles for Advanced Technologies N2 - Nanotubular tobacco mosaic virus (TMV) particles and RNA-free lower-order coat protein (CP) aggregates have been employed as enzyme carriers in different diagnostic layouts and compared for their influence on biosensor performance. In the following, we describe a label-free electrochemical biosensor for improved glucose detection by use of TMV adapters and the enzyme glucose oxidase (GOD). A specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CP aggregates was achieved via bioaffinity binding. Glucose sensors with adsorptively immobilized [SA]-GOD, and with [SA]-GOD cross-linked with glutardialdehyde, respectively, were tested in parallel on the same sensor chip. Comparison of these sensors revealed that TMV adapters enhanced the amperometric glucose detection remarkably, conveying highest sensitivity, an extended linear detection range and fastest response times. These results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for applications in biosensorics and biochips. Here, we describe the fabrication and use of amperometric sensor chips combining an array of circular Pt electrodes, their loading with GOD-modified TMV nanotubes (and other GOD immobilization methods), and the subsequent investigations of the sensor performance. KW - Tobacco mosaic virus (TMV) KW - Coat protein KW - Enzyme nanocarrier KW - Glucose biosensor KW - Glucose oxidase Y1 - 2018 SN - 978-1-4939-7808-3 U6 - http://dx.doi.org/10.1007/978-1-4939-7808-3 N1 - Methods in Molecular Biology, vol 1776 SP - 553 EP - 568 PB - Humana Press CY - New York, NY ER - TY - JOUR A1 - Kohler, Annette A1 - Kirschner-Hermanns, Ruth A1 - Staat, Manfred A1 - Brehmer, Bernhard T1 - Pathogenese, funktionelle und anatomische Aspekte der weiblichen Belastungsinkontinenz T1 - Female stress incontinence: aspects of pathogenesis and functional anatomy JF - Aktuelle Urologie N2 - Der vorliegende Artikel fokussiert sich auf die weibliche Belastungsinkontinenz als Insuffizienz der Speicherfunktion der Blase, auch wenn im klinischen Alltag die Harninkontinenz der Frau häufig verschiedene Ursachen hat und insbesondere eine Belastungsinkontinenz im Alter und bei neurologischer Komorbidität nur selten isoliert vorkommt. Das kleine Becken der Frau ist sowohl als Funktions- als auch als strukturelle Einheit zu betrachten. Dabei unterliegen bei der Frau Blase, Harnröhre, Gebärmutter und Enddarm sowie die muskulären und ligamentösen Strukturen des kleinen Beckens durch Fertilitätsphase, mögliche Schwangerschaften, Geburten und Menopausen-Phase, über das „normale Altern“ hinaus, gravierenden Veränderungen. This article focuses on female stress incontinence in the form of pelvic floor dysfunction and urethral sphincter deficiency, although isolated stress incontinence accounts for less than half of all incontinence cases. Especially in women of old age and those with neurological comorbidities, the causes of incontinence are mostly multifactorial. Also it has to be considered that the female bladder, urethra, uterus and rectum as well as the muscular and ligamentous structures of the female pelvis minor are affected by phases of fertility, possible pregnancies, births and menopause in addition to the normal ageing process. Y1 - 2018 U6 - http://dx.doi.org/10.1055/s-0043-120616 SN - 1438-8820 VL - 49 IS - 1 SP - 47 EP - 51 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines T1 - Vaskuläre Biomarker der retinalen Gefäβanalyse T1 - Vascular Biomarkers in Retinal Vessel Analysis JF - Klinische Monatsblätter fur Augenheilkunde N2 - Mit modernen nicht invasiven bildgebenden Verfahren lassen sich anhand der Fundusfotografie bzw. der optischen Verfilmung Aspekte der funktionellen und strukturellen retinalen Gefäßveränderungen objektiv untersuchen. Der Zustand und das Verhalten retinaler Gefäße beeinflussen im prä-, post- und kapillaren Bereich den Blutfluss und strömungsbedingte Stoffwechselverhältnisse passiv und aktiv über den Gefäßdurchmesser. Retinale Gefäße gleichen von Aufbau und Funktion den zerebralen Gefäßen und spiegeln den Zustand der Mikrozirkulation wider. Mithilfe von aus den Gefäßweiten berechneten Biomarkern soll eine Aussage über die Prognose von systemischen vaskulär bedingten Erkrankungen getroffen werden. Die statische retinale Gefäßanalyse befasst sich mit der Untersuchung des Zustandes der prä- und postkapillaren Gefäßdurchmesser der retinalen Mikrozirkulation anhand einer optischen Fundusaufnahme. Bei der dynamischen retinalen Gefäßanalyse wird der Längsschnitt eines retinalen Gefäßes nicht invasiv funktionell und strukturell über einen Zeitraum vor, während und nach einer spezifischen vaskulären Stimulation untersucht. Die genaue Methodologie der Auswertung und die Bezeichnung der Parameter variieren bei unterschiedlichen Ansätzen. Mittels retinaler Gefäßanalyse wurden bislang mehrere klinische Querschnitts- und Interventionsstudien in der Augenheilkunde und anderen Fachgebieten, inkl. Kardiologie, Neurologie, Neurochirurgie, Nephrologie, Gynäkologie, Sportmedizin, Diabetologie, Hypertensiologie usw. durchgeführt. Mit der statischen retinalen Gefäßanalyse steht eine kostengünstige, reproduzierbare, nicht invasive Screeningtechnik zur Verfügung, um eine prognostische Aussage über die Gefäßgesundheit eines individuellen Patienten zu treffen. Die dynamische retinale Gefäßanalyse besitzt ein weiteres diagnostisches Anwendungsspektrum als die statische, da sie das Verhalten retinaler Gefäße zeitkontinuierlich untersucht. Die Evaluation vaskulärer Erkrankungen sowie zerebro- bzw. kardiovaskulärer Morbidität und Mortalität mittels mehrerer methodologischer Modalitäten retinaler Gefäßanalyse mit ihren jeweiligen quantitativen Biomarkern bietet eine zukunftsträchtige diagnostische Perspektive. Die interdisziplinäre klinische Anwendung dieser vaskulären Biomarker gewinnt zunehmend an Bedeutung, sowohl in der Augenheilkunde als auch in anderen Fachgebieten. Y1 - 2018 U6 - http://dx.doi.org/10.1055/a-0774-7987 SN - 0023-2165 VL - 235 IS - 12 SP - 1352 EP - 1359 PB - Thieme CY - Stuttgart ER - TY - CHAP A1 - Krome, Cornelia A1 - Sander, Volker T1 - Time series analysis with apache spark and its applications to energy informatics T2 - Proceedings of the 7th DACH+ Conference on Energy Informatics N2 - In energy economy forecasts of different time series are rudimentary. In this study, a prediction for the German day-ahead spot market is created with Apache Spark and R. It is just an example for many different applications in virtual power plant environments. Other examples of use as intraday price processes, load processes of machines or electric vehicles, real time energy loads of photovoltaic systems and many more time series need to be analysed and predicted. This work gives a short introduction into the project where this study is settled. It describes the time series methods that are used in energy industry for forecasts shortly. As programming technique Apache Spark, which is a strong cluster computing technology, is utilised. Today, single time series can be predicted. The focus of this work is on developing a method to parallel forecasting, to process multiple time series simultaneously with R and Apache Spark. Y1 - 2018 U6 - http://dx.doi.org/10.1186/s42162-018-0043-1 N1 - Energy Informatics 2018, Volume 1 Supplement 1 ER - TY - JOUR A1 - Kunkel, Maximilian Hugo A1 - Gebhardt, Andreas A1 - Mpofu, Khumbaulani A1 - Kallweit, Stephan T1 - Statistical assessment of mechanical properties of selective laser melted specimens of stainless steel JF - The International Journal of Advanced Manufacturing Technology N2 - The rail business is challenged by long product life cycles and a broad spectrum of assembly groups and single parts. When spare part obsolescence occurs, quick solutions are needed. A reproduction of obsolete parts is often connected to long waiting times and minimum lot quantities that need to be purchased and stored. Spare part storage is therefore challenged by growing stocks, bound capital and issues of part ageing. A possible solution could be a virtual storage of spare parts which will be 3D printed through additive manufacturing technologies in case of sudden demand. As mechanical properties of additive manufactured parts are neither guaranteed by machine manufacturers nor by service providers, the utilization of this relatively young technology is impeded and research is required to address these issues. This paper presents an examination of mechanical properties of specimens manufactured from stainless steel through the selective laser melting (SLM) process. The specimens were produced in multiple batches. This paper interrogates the question if the test results follow a normal distribution pattern and if mechanical property predictions can be made. The results will be put opposite existing threshold values provided as the industrial standard. Furthermore, probability predictions will be made in order to examine the potential of the SLM process to maintain state-of-the-art mechanical property requirements. Y1 - 2018 U6 - http://dx.doi.org/10.1007/s00170-018-2040-8 SN - 0268-3768 VL - 98 IS - 5-8 SP - 1409 EP - 1431 PB - Springer CY - London ER - TY - BOOK A1 - Kurz, Melanie T1 - Designstreit : exemplarische Kontroversen über Gestaltung N2 - Die Geschichte des Designs ist gesäumt von Auseinandersetzungen. Debattiert wird unter Berufsgenossen, in Interessensverbänden, zwischen Wettbewerbern und nicht zuletzt an Hochschulen; als Foren dienen zum Beispiel Zeitungen, Konferenzen oder Gerichtssäle. Doch welche Gründe gibt es für Streit über Design? Die Kontroversen beschränken sich keineswegs auf die Ästhetik von Artefakten. Auch haben wir es trotz der Vielfalt an Streitfällen nicht mit einem unüberschaubaren Feld von zusammenhanglosen Einzelereignissen zu tun. Wie das vorliegende Buch anhand historischer Kontroversen zeigt, lassen sich im Bereich der Gestaltung Streitkategorien identifizieren. Die Diskursanalyse verrät, dass sich die Konfliktursachen im Verlauf der Designhistorie kaum verändern. So haben die angeführten Dispute erstaunliche Ähnlichkeit mit aktuellen Debatten im Fach. Sie sind Lehrstücke und können dazu anregen, eine Streitkultur im Design zu etablieren, die sich davon distanziert, den Meinungsgegner in ein politisches Lager zu ›verräumen‹. Y1 - 2018 SN - 978-3-7705-6294-7 (Druckausgabe) SN - 978-3-8467-6294-3 (E-Book) PB - Wilhelm Fink CY - Paderborn ER - TY - JOUR A1 - Kurz, Melanie T1 - Was heißt: Verantwortung im Design? Historische Positionen JF - Boxhorn: das Magazin aus dem Fachbereich Gestaltung der FH Aachen Y1 - 2018 IS - 34 SP - 26 EP - 33 CY - Aachen ER - TY - CHAP A1 - König, Johannes Alexander A1 - Völker, Veronika A1 - Wolf, Martin T1 - The user-focused storybuilding framework for competence developing games - a design-framework considering the basics of an educational game’s story T2 - ACHI 2018 : The Eleventh International Conference on Advances in Computer-Human Interactions N2 - During the development of a Competence Developing Game’s (CDG) story it is indispensable to understand the target audience. Thereby, CDGs stories represent more than just the plot. The Story is about the Setting, the Characters and the Plot. As a toolkit to support the development of such a story, this paper introduces the UserFocused Storybuilding (short UFoS) Framework for CDGs. The Framework and its utilization will be explained, followed by a description of its development and derivation, including an empirical study. In addition, to simplify the Framework use regarding the CDG’s target audience, a new concept of Nine Psychographic Player Types will be explained. This concept of Player Types provides an approach to handle the differences in between players during the UFoS Framework use. Thereby, this article presents a unique approach to the development of target group-differentiated CDGs stories. KW - Competence Developing Game KW - Serious Game KW - Video Game KW - Story KW - Player Types Y1 - 2018 SN - 978-1-61208-616-3 N1 - Proceeding of the Eleventh International Conference on Advances in Computer-Human Interactions (ACHI 2018), Rome, Italy. SP - 98 EP - 106 ER - TY - JOUR A1 - König, Johannes Alexander A1 - Wolf, Martin T1 - GHOST: An Evaluated Competence Developing Game for Cybersecurity Awareness Training JF - International Journal on Advances in Security N2 - To train end users how to interact with digital systems is indispensable to ensure a strong computer security. 'Competence Developing Game'-based approaches are particularly suitable for this purpose because of their motivation-and simulation-aspects. In this paper the Competence Developing Game 'GHOST' for cybersecurity awareness trainings and its underlying patterns are described. Accordingly, requirements for an 'Competence Developing Game' based training are discussed. Based on these requirements it is shown how a game can fulfill these requirements. A supplementary game interaction design and a corresponding evaluation study is shown. The combination of training requirements and interaction design is used to create a 'Competence Developing Game'-based training concept. A part of these concept is implemented into a playable prototype that serves around one hour of play respectively training time. This prototype is used to perform an evaluation of the game and training aspects of the awareness training. Thereby, the quality of the game aspect and the effectiveness of the training aspect are shown. Y1 - 2018 SN - 1942-2636 VL - 11 IS - 3 & 4 SP - 274 EP - 287 PB - IARIA Journals ER - TY - CHAP A1 - König, Johannes Alexander A1 - Wolf, Martin T1 - Cybersecurity awareness training provided by the competence developing game GHOST T2 - ACHI 2018 : The Eleventh International Conference on Advances in Computer-Human Interactions N2 - This paper introduces a Competence Developing Game (CDG) for the purpose of a cybersecurity awareness training for businesses. The target audience will be discussed in detail to understand their requirements. It will be explained why and how a mix of business simulation and serious game meets these stakeholder requirements. It will be shown that a tablet and touchscreen based approach is the most suitable solution. In addition, an empirical study will be briefly presented. The study was carried out to examine how an interaction system for a 3D-tablet based CDG has to be designed, to be manageable for non-game experienced employees. Furthermore, it will be explained which serious content is necessary for a Cybersecurity awareness training CDG and how this content is wrapped in the game KW - Awareness KW - CDG KW - Serious Game KW - tablet game KW - business simulation Y1 - 2018 SN - 978-1-61208-616-3 N1 - Proceeding of the Eleventh International Conference on Advances in Computer-Human Interactions (ACHI 2018), Rome, Italy. SP - 81 EP - 87 ER - TY - BOOK A1 - Laack, Walter van T1 - Sterben und Tod aus wissenschaftlicher Sicht - dying and death from a scientific point of view Y1 - 2018 SN - 978-3-936624-41-0 PB - van Laack GmbH CY - Aachen ER - TY - JOUR A1 - Lapitan, Denis G. A1 - Rogatkin, Dmitrii A. A1 - Persheyev, Sydulla K. A1 - Kotliar, Konstantin T1 - False spectra formation in the differential two-channel scheme of the laser Doppler flowmeter JF - Biomedizinische Technik N2 - Noise in the differential two-channel scheme of a classic laser Doppler flowmetry (LDF) instrument was studied. Formation of false spectral components in the output signal due to beating of electrical signals in the differential amplifier was found out. The improved block-diagram of the flowmeter was developed allowing to reduce the noise. Y1 - 2018 U6 - http://dx.doi.org/10.1515/bmt-2017-0060 SN - 0013-5585 VL - 63 IS - 4 SP - 439 EP - 444 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Laura, C.O. A1 - Drechsler, Klaus A1 - Erdt, M. A1 - Wesarg, S. A1 - Bale, R. T1 - Intervention assessment tool for primary tumors in the liver JF - Current Directions in Biomedical Engineering N2 - After a liver tumor intervention the medical doctor has to compare both pre and postoperative CT acquisitions to ensure that all carcinogenic cells are destroyed. A correct assessment of the intervention is of vital importance, since it will reduce the probability of tumor recurrence. Some methods have been proposed to support the medical doctors during the assessment process, however, all of them focus on secondary tumors. In this paper a tool is presented that enables the outcome validation for both primary and secondary tumors. Therefore, a multiphase registration (preoperative arterial and portal phases) followed by a registration between the pre and postoperative CT images is carried out. The first registration is in charge of the primary tumors that are only visible in the arterial phase. The secondary tumors will be incorporated in the second registration step. Finally, the part of the tumor that was not covered by the necrosis is quantified and visualized. The method has been tested in 9 patients, with an average registration error of 1.41 mm. Y1 - 2018 U6 - http://dx.doi.org/10.1515/cdbme-2018-0081 SN - 2364-5504 VL - 4 IS - 1 SP - 337 EP - 340 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Leise, Philipp A1 - Altherr, Lena T1 - Optimizing the design and control of decentralized water supply systems – a case-study of a hotel building T2 - EngOpt 2018 Proceedings of the 6th International Conference on Engineering Optimization N2 - To increase pressure to supply all floors of high buildings with water, booster stations, normally consisting of several parallel pumps in the basement, are used. In this work, we demonstrate the potential of a decentralized pump topology regarding energy savings in water supply systems of skyscrapers. We present an approach, based on Mixed-Integer Nonlinear Programming, that allows to choose an optimal network topology and optimal pumps from a predefined construction kit comprising different pump types. Using domain-specific scaling laws and Latin Hypercube Sampling, we generate different input sets of pump types and compare their impact on the efficiency and cost of the total system design. As a realistic application example, we consider a hotel building with 325 rooms, 12 floors and up to four pressure zones. KW - Engineering optimization KW - Energy efficiency KW - Water KW - Pump System KW - Latin Hypercube Sampling Y1 - 2018 SN - 978-3-319-97773-7 SN - 978-3-319-97772-0 U6 - http://dx.doi.org/10.1007/978-3-319-97773-7_107 N1 - EngOpt 2018 Proceedings of the 6th International Conference on Engineering Optimization. 17-19 September 2018. Lisboa, Portugal SP - 1241 EP - 1252 PB - Springer CY - Cham ER - TY - CHAP A1 - Leise, Philipp A1 - Altherr, Lena A1 - Pelz, Peter F. T1 - Technical Operations Research (TOR) - Algorithms, not Engineers, Design Optimal Energy Efficient and Resilient Cooling Systems T2 - FAN2018 - Proceedings of the International Conference on Fan Noise, Aerodynamics, Applications and Systems N2 - The overall energy efficiency of ventilation systems can be improved by considering not only single components, but by considering as well the interplay between every part of the system. With the help of the method "TOR" ("Technical Operations Research"), which was developed at the Chair of Fluid Systems at TU Darmstadt, it is possible to improve the energy efficiency of the whole system by considering all possible design choices programmatically. We show the ability of this systematic design approach with a ventilation system for buildings as a use case example. Based on a Mixed-Integer Nonlinear Program (MINLP) we model the ventilation system. We use binary variables to model the selection of different pipe diameters. Multiple fans are model with the help of scaling laws. The whole system is represented by a graph, where the edges represent the pipes and fans and the nodes represents the source of air for cooling and the sinks, that have to be cooled. At the beginning, the human designer chooses a construction kit of different suitable fans and pipes of different diameters and different load cases. These boundary conditions define a variety of different possible system topologies. It is not possible to consider all topologies by hand. With the help of state of the art solvers, on the other side, it is possible to solve this MINLP. Next to this, we also consider the effects of malfunctions in different components. Therefore, we show a first approach to measure the resilience of the shown example use case. Further, we compare the conventional approach with designs that are more resilient. These more resilient designs are derived by extending the before mentioned model with further constraints, that consider explicitly the resilience of the overall system. We show that it is possible to design resilient systems with this method already in the early design stage and compare the energy efficiency and resilience of these different system designs. Y1 - 2018 N1 - International Conference on Fan Noise, Aerodynamics, Applications and Systems 18-20.04.2018 Darmstadt, Deutschland SP - 1 EP - 12 ER - TY - CHAP A1 - Leise, Philipp A1 - Altherr, Lena A1 - Pelz, Peter F. T1 - Energy-Efficient design of a water supply system for skyscrapers by mixed-integer nonlinear programming T2 - Operations Research Proceedings 2017 N2 - The energy-efficiency of technical systems can be improved by a systematic design approach. Technical Operations Research (TOR) employs methods known from Operations Research to find a global optimal layout and operation strategy of technical systems. We show the practical usage of this approach by the systematic design of a decentralized water supply system for skyscrapers. All possible network options and operation strategies are modeled by a Mixed-Integer Nonlinear Program. We present the optimal system found by our approach and highlight the energy savings compared to a conventional system design. KW - Engineering optimization KW - Global optimization KW - Energy efficiency KW - Water KW - Network Y1 - 2018 SN - 978-3-319-89919-0 U6 - http://dx.doi.org/10.1007/978-3-319-89920-6_63 PB - Springer CY - Cham ER - TY - JOUR A1 - Lind, Thorsten Patric T1 - Neues zur Geschäftsführerhaftung nach § 64 GmbHG - Zugleich Anmerkung zu BGH vom 19.12.2017 - II ZR 88/16, DB 2018 S. 307, und vom 04.07.2017 - II ZR 319/15, DB 2017 S. 1959 - JF - Der Betrieb Y1 - 2018 SN - 0005-9935 IS - 17 SP - 1003 EP - 1008 PB - Fachmedien Otto Schmidt CY - Düsseldorf ER - TY - GEN A1 - Lind, Thorsten Patric T1 - Antrag auf Löschung von Insolvenzvermerken bei Insolvenz eines GbR-Gesellschafters T2 - Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-Möhring Y1 - 2018 SN - 1611-1095 N1 - BGH Beschl. v. 13.7.2017 – V ZB 136/16, LMK 2018, 401892 ER - TY - CHAP A1 - Ludowicy, Jonas A1 - Rings, René A1 - Finger, Felix A1 - Braun, Carsten T1 - Sizing Studies of Light Aircraft with Serial Hybrid Propulsion Systems T2 - Luft- und Raumfahrt - Digitalisierung und Vernetzung : Deutscher Luft- und Raumfahrtkongress 2018. 4. - 6. September 2018 - Friedrichshafen Y1 - 2018 ER - TY - CHAP A1 - Ludowicy, Jonas A1 - Rings, René A1 - Finger, Felix A1 - Braun, Carsten T1 - Sizing Studies of Light Aircraft with Parallel Hybrid Propulsion Systems T2 - Deutscher Luft- und Raumfahrtkongress 2018 Y1 - 2018 U6 - http://dx.doi.org/10.25967/480227 ER -