TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Shalaby, Ahmed
A1  - Shasha, Carolyn
A1  - Krishnan, Kannan M.
A1  - Krause, Hans-Joachim
T1  - Comparative modeling of frequency mixing measurements of magnetic nanoparticles using micromagnetic simulations and Langevin theory
JF  - Nanomaterials
N2  - Dual frequency magnetic excitation of magnetic nanoparticles (MNP) enables enhanced biosensing applications. This was studied from an experimental and theoretical perspective: nonlinear sum-frequency components of MNP exposed to dual-frequency magnetic excitation were measured as a function of static magnetic offset field. The Langevin model in thermodynamic equilibrium was fitted to the experimental data to derive parameters of the lognormal core size distribution. These parameters were subsequently used as inputs for micromagnetic Monte-Carlo (MC)-simulations. From the hysteresis loops obtained from MC-simulations, sum-frequency components were numerically demodulated and compared with both experiment and Langevin model predictions. From the latter, we derived that approximately 90% of the frequency mixing magnetic response signal is generated by the largest 10% of MNP. We therefore suggest that small particles do not contribute to the frequency mixing signal, which is supported by MC-simulation results. Both theoretical approaches describe the experimental signal shapes well, but with notable differences between experiment and micromagnetic simulations. These deviations could result from Brownian relaxations which are, albeit experimentally inhibited, included in MC-simulation, or (yet unconsidered) cluster-effects of MNP, or inaccurately derived input for MC-simulations, because the largest particles dominate the experimental signal but concurrently do not fulfill the precondition of thermodynamic equilibrium required by Langevin theory.
KW  - Magnetic nanoparticles
KW  - Frequency mixing magnetic detection
KW  - Langevin theory
KW  - Micromagnetic simulation
KW  - Nonequilibrium dynamics
Y1  - 2021
SN  - 2079-4991
U6  - http://dx.doi.org/10.3390/nano11051257
N1  - This article belongs to the Special Issue Applications and Properties of Magnetic Nanoparticles
VL  - 11
IS  - 5
SP  - 1
EP  - 16
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Engelmann, Ulrich M.
A1  - Shasha, Carolyn
A1  - Slabu, Ioana
T1  - Magnetic nanoparticle relaxation in biomedical application: focus on simulating nanoparticle heating
T2  - Magnetic nanoparticles in human health and medicine
Y1  - 2021
SN  - 978-1-119-75467-1
SP  - 327
EP  - 354
PB  - Wiley-Blackwell
CY  - Hoboken, New Jeersey
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Shasha, Carolyn
A1  - Teeman, Eric
A1  - Slabu, Iona
A1  - Krishnan, Kannan M.
T1  - Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic Néel-Brown Langevin simulation
JF  - Journal of Magnetism and Magnetic Materials
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.jmmm.2018.09.041
SN  - 0304-8853
VL  - 471
IS  - 1
SP  - 450
EP  - 456
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Simsek, Beril
A1  - Shalaby, Ahmed
A1  - Krause, Hans-Joachim
T1  - Key contributors to signal generation in frequency mixing magnetic detection (FMMD): an in silico study
JF  - Sensors
N2  - Frequency mixing magnetic detection (FMMD) is a sensitive and selective technique to detect magnetic nanoparticles (MNPs) serving as probes for binding biological targets. Its principle relies on the nonlinear magnetic relaxation dynamics of a particle ensemble interacting with a dual frequency external magnetic field. In order to increase its sensitivity, lower its limit of detection and overall improve its applicability in biosensing, matching combinations of external field parameters and internal particle properties are being sought to advance FMMD. In this study, we systematically probe the aforementioned interaction with coupled Néel–Brownian dynamic relaxation simulations to examine how key MNP properties as well as applied field parameters affect the frequency mixing signal generation. It is found that the core size of MNPs dominates their nonlinear magnetic response, with the strongest contributions from the largest particles. The drive field amplitude dominates the shape of the field-dependent response, whereas effective anisotropy and hydrodynamic size of the particles only weakly influence the signal generation in FMMD. For tailoring the MNP properties and parameters of the setup towards optimal FMMD signal generation, our findings suggest choosing large particles of core sizes dc > 25 nm nm with narrow size distributions (σ < 0.1) to minimize the required drive field amplitude. This allows potential improvements of FMMD as a stand-alone application, as well as advances in magnetic particle imaging, hyperthermia and magnetic immunoassays.
KW  - key performance indicators
KW  - magnetic biosensing
KW  - coupled Néel–Brownian relaxation dynamics
KW  - frequency mixing magnetic detection
KW  - magnetic relaxation
KW  - micromagnetic simulation
KW  - magnetic nanoparticles
Y1  - 2024
U6  - http://dx.doi.org/10.3390/s24061945
SN  - 1424-8220
N1  - This article belongs to the Special Issue "Advances in Magnetic Sensors and Their Applications"
VL  - 24
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Erbayraktar, Zubeyde
A1  - Yilmaz, Osman
A1  - Temiz Artmann, Aysegül
A1  - Cehreli, Ruksan
A1  - Coker, Canan
T1  - Effects of Selenium Supplementation on Antioxidant Defense and Glucose Homeostasis in Experimental Diabetes Mellitus
JF  - Biological Trace Element Research
Y1  - 2007
SN  - 1559-0720
VL  - 118
IS  - 3
SP  - 217
EP  - 226
ER  - 
TY  - JOUR
A1  - Erki, I.
A1  - Kleines, H.
A1  - Ziemons, Karl
A1  - Zwoll, K.
ED  - Lehmann, Thomas
T1  - Interaktives System zur Darstellung funktionaler Bilddaten
JF  - Bildverarbeitung für die Medizin : Algorithmen - Systeme - Anwendungen
Y1  - 1997
SN  - 3-86073-519-5
N1  - Proceedings des Aachener Workshops am 8. u. 9. November 1996 ; PP_002 Posterpräsentation
SP  - 249
EP  - 254
PB  - Verl. der. Augustinus-Buchh.
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T
A1  - Mourzina, Y.
A1  - Levichev, S.
A1  - Furuichi, K.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Photocurable membranes for ion-selective light-addressable potentiometric sensors
JF  - Sensors and Actuators B. 85 (2002), H. 1-2
Y1  - 2002
SN  - 0925-4005
SP  - 79
EP  - 85
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Furuichi, K.
A1  - Iwasaki, H.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
T1  - Technology of photocurable polymeric membranes for integrated LAPS
JF  - Proceedings of the 5th East Asian Conference on Chemical Sensors; the 33rd Chemical Sensor Symposium : December 4 - 7, 2001, Huis Ten Bosch, Sasebo-shi, Nagasaki, Japan / Japan Association of Chemical Sensors; the Electrochemical Society of Japan
Y1  - 2001
N1  - Chemical sensors; 17.2001 Suppl. B; East Asian Conference on Chemical Sensors ; (5, 2001; Nagasaki)
SP  - 66
EP  - 68
PB  - Japan Association of Chemical Sensors
CY  - Kasuga, Fukuoka-ken
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Furuichi, K.
A1  - Levichev, S.
A1  - Vlasov, Y.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Lithium sensor based on the laser scanning semiconductor transducer
JF  - Analytica Chimica Acta. 459 (2002), H. 1
Y1  - 2002
SN  - 0378-4304
SP  - 1
EP  - 9
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
A1  - Furuichi, K.
A1  - Levichev, S.
A1  - Vlasov, Y.
A1  - Iwasaki, H.
T1  - The double K+/Ca2+ sensor based on laser scanned silicon transducer (LSST) for multicomponent analysis
JF  - Talanta. 59 (2003), H. 4
Y1  - 2003
SN  - 0039-9140
SP  - 785
EP  - 795
ER  - 
TY  - JOUR
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
A1  - Vlasov, Y.
A1  - Iwasaki, H.
T1  - The hybrid K+/Ca2+ sensor based on laser scanned silicon transducer for multi-component analysis
JF  - Proceedings of ICAS 2001, IUPAC [3rd] International Congress on Analytical Sciences 2001 : August 6 - 10, 2001, Waseda University, Tokyo
Y1  - 2002
N1  - International Congress on Analytical Sciences <2001, Tokyo> ; International Union of Pure and Applied Chemistry. Pure and applied chemistry ; 73,10. ; Analytical sciences ; 17.2001, special issue
SP  - i777
EP  - i780
PB  - Japan Society for Analytical Chemistry
CY  - Tokyo
ER  - 
TY  - CHAP
A1  - Ermelenko, Y.
A1  - Yoshinobu, T.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
A1  - Vlasov, Y.
A1  - Iwasaki, H.
T1  - A multisensor based on laser scanned silicon transducer (LSST): development and properties
T2  - Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimarães, Portugal, September 21 - 24, 2003
Y1  - 2003
SP  - 72
EP  - 73
ER  - 
TY  - JOUR
A1  - Ermolaev, A.P.
A1  - Nivokov, I.A.
A1  - Melnikova, L.I.
A1  - Kotliar, Konstantin
T1  - Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой
T1  - Comparative characteristics of the chemical composition of vitreal contents of cadaver eyes and eyes with terminal refractory glaucoma
JF  - Vestnik oftalmologii
N2  - Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP.
Y1  - 2018
U6  - http://dx.doi.org/10.17116/oftalma2018134051195
VL  - 5
IS  - 2
SP  - 195
EP  - 201
PB  - Media Sfera
CY  - Moskau
ER  - 
TY  - JOUR
A1  - Ermolaev, AP
A1  - Erichev, VP
A1  - Antonov, AA
A1  - Grigoryan, GL
A1  - Kotliar, Konstantin
A1  - Levitsky, YV
A1  - Hderi, K
A1  - Mazurova, YV
T1  - Assessing retinal photosensitivity in patients with central vision impairment using a portable perimeter (a preliminary report)
JF  - Vestnik oftalmologii
Y1  - 2019
U6  - http://dx.doi.org/10.17116/oftalma201913503146
N1  - Abstract in Englisch
VL  - 135
IS  - 3
SP  - 46
EP  - 54
ER  - 
TY  - JOUR
A1  - Ermolenko, Y. E.
A1  - Yoshinobu, T.
A1  - Mourzina, Y. G.
A1  - Vlasov, Y. G.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Laserscanned transducer (LSST) as a multisensor system
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 457
EP  - 462
ER  - 
TY  - JOUR
A1  - Ermolenko, Y.E.
A1  - Vlasov, Y.G.
A1  - Kolodnikov, V.V.
A1  - Shabaldkin, D. A.
A1  - Kloock, Joachim P.
A1  - Schöning, Michael Josef
T1  - Diffusion of radioactive tracers (204Tl, 110mAg) and ionic conductivity in membrane materials for the chemical sensors
JF  - Advances in nuclear and radiochemistry : extended abstracts of papers presented at the Sixth International Conference on Nuclear and Radiochemistry (NRC-6), 29 August to 3 September 2004, Aachen, Germany ; in cooperation with University of Cologne, GDCh, FECS, OECD-NEA and IAEA / Syed M. Qaim ... (eds.).
Y1  - 2004
SN  - 3893363629
N1  - Schriften des Forschungszentrums Jülich Reihe Allgemeines und Interdisziplinäres ; 3. International Conference on Nuclear and Radiochemistry ; (6, 2004, Aachen)
SP  - 483
EP  - 485
PB  - Forschungszentrum Jülich, Zentralbibliothek
CY  - Jülich
ER  - 
TY  - CHAP
A1  - Eschler, Eric
A1  - Wozniak, Felix
A1  - Richter, Christoph
A1  - Drechsler, Klaus
T1  - Materialanalyse an lokal verstärkten Triaxialgeflechten
T2  - Leichtbau in Forschung und industrieller Anwendung von der Nano- bis zur Makroebene, LLC, Landshuter Leichtbau-Colloquium, 9
Y1  - 2019
SN  - 978-3-9818439-2-7
SP  - 120
EP  - 131
PB  - Leichtbau Cluster
CY  - Landshut
ER  - 
TY  - JOUR
A1  - Eschweiler, J.
A1  - Laack, Walter van
A1  - Staat, Manfred
T1  - Elektromyographische Untersuchungen zur Kräftigung der Oberschenkelmuskulatur mit einem myoelektrischen Stimulator nach arthroskopischen Eingriffen am Kniegelenk
JF  - Orthopädische Praxis. 43 (2007), H. 10
Y1  - 2007
SN  - 0030-588x
SP  - 539
EP  - 542
ER  - 
TY  - JOUR
A1  - Faßbender, F.
A1  - Schmitt, G.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
A1  - Buß, G.
A1  - Schultze, J. W.
T1  - Optimization of passivation layers for corrosion protection of silicon-based microelectrode arrays
JF  - Sensors and Actuators B. 68 (2000), H. 1-3
Y1  - 2000
SN  - 0925-4005
SP  - 128
EP  - 133
ER  - 
TY  - JOUR
A1  - Faßbender, F.
A1  - Schmitt, G.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
A1  - Buß, G.
A1  - Schultze, J. W.
T1  - Passivation and corrosion of microsensor devices exemplified at microelectrode arrays
JF  - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.
Y1  - 1999
SN  - 90-76699-02-X
N1  - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague)
SP  - 953
EP  - 956
CY  - The Hague, The Netherlands
ER  -