TY  - JOUR
A1  - Wilson, C. E.
A1  - Dickie, A. P.
A1  - Schreiter, K.
A1  - Wehr, R.
A1  - Wilson, E. M.
A1  - Bial, J.
A1  - Scheer, Nico
A1  - Wilson, I. D.
A1  - Riley, R. J.
T1  - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
JF  - Archives of Toxicology
N2  - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.
Y1  - 2018
U6  - https://doi.org/10.1007/s00204-018-2212-1
SN  - 1432-0738
VL  - 92
IS  - 6
SP  - 1953
EP  - 1967
PB  - Springer
ER  - 
TY  - JOUR
A1  - Wilson, Ian D.
A1  - Wilson, Claire E.
A1  - Scheer, Nico
A1  - Dickie, A.P.
A1  - Schreiter, K.
A1  - Wilson, E. M.
A1  - Riley, R. J.
A1  - Wehr, R.
A1  - Bial, J.
T1  - The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
JF  - Biochemical pharmacology
Y1  - 2017
U6  - https://doi.org/10.1016/j.bcp.2017.03.015
SN  - 1873-2968
VL  - Volume 135
SP  - 139
EP  - 150
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wilson, T. L.
A1  - Blome, Hans-Joachim
T1  - The Pioneer anomaly and a rotating Gödel universe
JF  - Advances in Space Research
Y1  - 2009
SN  - 0273-1177
VL  - 44
IS  - 11
SP  - 1345
EP  - 1353
ER  - 
TY  - JOUR
A1  - Wilson, Thomas L
A1  - Blome, Hans-Joachim
A1  - LaFave, Norman
T1  - Astrophysical Cosmology Using a Lunar Ligo
JF  - Engineering, construction, and operations in space V : proceedings of the Fifth International Conference on Space '96, Albuquerque, New Mexico, June 1-6, 1996 / sponsored by Aerospace Division of the American Society of Civil Engineers ... [et al.]; edite
Y1  - 1996
SN  - 0-7844-0177-2
SP  - 861
EP  - 863
PB  - The Society
CY  - New York
ER  - 
TY  - JOUR
A1  - Winckler, Silvia
A1  - Krueger, Rolf
A1  - Schnitzler, Thomas
A1  - Zang, Werner
A1  - Fischer, Rainer
A1  - Biselli, Manfred
T1  - A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach
JF  - Bioprocess and biosystems engineering
N2  - Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.
Y1  - 2014
U6  - https://doi.org/10.1007/s00449-013-1062-8
SN  - 1615-7591 (Print) 1615-7605 (Online)
VL  - 37
IS  - 5
SP  - 901
EP  - 912
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - JOUR
A1  - Windmüller, Anna
A1  - Schaps, Kristian
A1  - Zantis, Frederik
A1  - Domgans, Anna
A1  - Taklu, Bereket Woldegbreal
A1  - Yang, Tingting
A1  - Tsai, Chih-Long
A1  - Schierholz, Roland
A1  - Yu, Shicheng
A1  - Kungl, Hans
A1  - Tempel, Hermann
A1  - Dunin-Borkowski, Rafal E.
A1  - Hüning, Felix
A1  - Hwang, Bing Joe
A1  - Eichel, Rüdiger-A.
T1  - Electrochemical activation of LiGaO2: implications for ga-doped garnet solid electrolytes in li-metal batteries
JF  - ACS Applied Materials & Interfaces
N2  - Ga-doped Li7La3Zr2O12 garnet solid electrolytes exhibit the highest Li-ion conductivities among the oxide-type garnet-structured solid electrolytes, but instabilities toward Li metal hamper their practical application. The instabilities have been assigned to direct chemical reactions between LiGaO2 coexisting phases and Li metal by several groups previously. Yet, the understanding of the role of LiGaO2 in the electrochemical cell and its electrochemical properties is still lacking. Here, we are investigating the electrochemical properties of LiGaO2 through electrochemical tests in galvanostatic cells versus Li metal and complementary ex situ studies via confocal Raman microscopy, quantitative phase analysis based on powder X-ray diffraction, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and electron energy loss spectroscopy. The results demonstrate considerable and surprising electrochemical activity, with high reversibility. A three-stage reaction mechanism is derived, including reversible electrochemical reactions that lead to the formation of highly electronically conducting products. The results have considerable implications for the use of Ga-doped Li7La3Zr2O12 electrolytes in all-solid-state Li-metal battery applications and raise the need for advanced materials engineering to realize Ga-doped Li7La3Zr2O12for practical use.
KW  - LiGaO2
KW  - garnet solid electrolyte
KW  - ga-doping
KW  - Li7La3Zr2O12
KW  - solid-state battery
Y1  - 2024
U6  - https://doi.org/10.1021/acsami.4c03729
SN  - 39181–3919
VL  - 16
IS  - 30
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Wissen, M.
A1  - Bogdanski, N.
A1  - Scheer, H.-C.
A1  - Bitz, Andreas
A1  - Ahrens, G.
A1  - Gruetzner, G.
T1  - Implication of the light polarisation for UV curing of pre-patterned resists
JF  - Microelectronic Engineering
Y1  - 2005
U6  - https://doi.org/10.1016/j.mee.2004.12.099
SN  - 0167-9317
VL  - 78-79
SP  - 659
EP  - 664
ER  - 
TY  - JOUR
A1  - Wissenbach, U.
A1  - Six, S.
A1  - Bongaerts, Johannes
A1  - Ternes, D.
A1  - Steinwachs, S.
A1  - Unden, G.
T1  - A third periplasmic transport system for l-arginine in Escherichia coli: molecular characterization of the artPIQMJ genes, arginine binding and transport
JF  - Molecular microbiology
Y1  - 1995
SN  - 1365-2958 (E-Journal); 0950-382x (Print)
VL  - Vol. 17
IS  - Iss. 4
SP  - 675
EP  - 686
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
T1  - The microgravity User Support Centre
JF  - Space Technology - Industrial and Commercial Applications. 13 (1993), H. 2
Y1  - 1993
SN  - 0892-9270
SP  - 121
EP  - 124
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
T1  - Overview of Space Operations at DLR
Y1  - 2000
N1  - SpaceOps2000 Conference, Toulouse, Frankreich,19-23 June 2000
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Bewersdorff, A.
A1  - Görler, G.P.
A1  - Otto, G.
T1  - Solidification of silver-germanium alloys in an amorphous matrix aboard the space station Mir
JF  - Acta Astronautica. 29 (1993), H. 7
Y1  - 1993
SN  - 0094-5765
SP  - 547
EP  - 552
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Bibring, J.-P.
A1  - Rosenbauer, H.
A1  - Boehnhardt, H.
T1  - The Rosetta Lander (“Philae”) Investigations  / Bibring, J.-P. ; Rosenbauer, H. ; Boehnhardt, H. ;  [...] Wittmann, K.
JF  - Space Science Reviews. 128 (2007), H. 1-4
Y1  - 2007
SN  - 0038-6308
SP  - 205
EP  - 220
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Feuerbacher, B.
A1  - Ulamec, S.
A1  - Rosenbauer, H. (u.a.)
T1  - Rosetta Lander - In Situ Characterisation of a Comet Nucleus
JF  - Acta Astronautica. 45 (1999), H. 4-9
Y1  - 1999
SN  - 0094-5765
SP  - 389
EP  - 395
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Fortezza, R.
T1  - Telescience opportunities in the precursor flights
JF  - Space Technology - Industrial and Commercial Applications. 13 (1992), H. 2
Y1  - 1992
SN  - 0892-9270
SP  - 221
EP  - 226
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Gillessen, F.
A1  - Otto, G.
A1  - Röstel, R.
T1  - Undercooling and solidification of metallic melts suspended in a non-nucleating matrix: Experiment NUCAL of the German Spacelab Mission D-2
JF  - Acta Astronautica. 38 (1996), H. 1
Y1  - 1996
SN  - 0094-5765
SP  - 63
EP  - 68
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Kehr, J.
A1  - Willnecker, R.
T1  - Decentralized Payload Operations Concept for Columbus
Y1  - 2000
N1  - 51st IAF Congress, Rio de Janeiro, Brazil, Oct. 2000
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Kell, G.
A1  - Winkler, F.
A1  - Günther, M. (u.a.)
T1  - High resolution temperature measurement technique for materials sciences experiments in space
JF  - Acta Astronautica. 43 (1998), H. 7-8
Y1  - 1998
SN  - 0094-5765
SP  - 385
EP  - 395
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Padeken, D.
T1  - The User Center for Microgravity MUSC - Support for space experiments
JF  - DLR-Nachrichten. 70 (1993)
Y1  - 1993
SN  - 0937-0420
SP  - 19
EP  - 24
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Schmidt, H. P.
A1  - Feuerbacher, B.
T1  - Microgravity research and user support in the Space Station era: The Microgravity User Support Centre
JF  - Acta Astronautica. 17 (1988), H. 11-12
Y1  - 1988
SN  - 0094-5765
SP  - 1161
EP  - 1168
ER  - 
TY  - JOUR
A1  - Wittmann, Klaus
A1  - Schmidt, H. P.
A1  - Padeken, D.
A1  - Hildmann, B.
T1  - The Microgravity User Support Centre (MUSC)
JF  - ESA SP. 277 (1988)
Y1  - 1988
SN  - 0379-6566
N1  - Proceedings of the International Symposium on Europe in Space--the Manned Space System : 25-29 April 1988, Strasbourg, France  David, Valerie ; Longdon, Norman [ed]
SP  - 525
ER  -