TY - JOUR A1 - Quittmann, Oliver J. A1 - Abel, Thomas A1 - Albracht, Kirsten A1 - Strüder, Heiko K. T1 - Reliability of muscular activation patterns and their alterations during incremental handcycling in able-bodied participants JF - Sports Biomechanics Y1 - 2019 U6 - https://doi.org/10.1080/14763141.2019.1593496 SN - 1752-6116 IS - Article in press PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Raman, Aravind Hariharan A1 - Jung, Alexander A1 - Horváth, András A1 - Becker, Nadine A1 - Staat, Manfred ED - Staat, Manfred ED - Erni, Daniel T1 - Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich). Y1 - 2019 SN - 978-3-940402-22-6 U6 - https://doi.org/10.17185/duepublico/48750 SP - 10 EP - 11 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Rao, Deepak A1 - Pathrose, Plato A1 - Hüning, Felix A1 - Sid, Jithin T1 - An Approach for Validating Safety of Perception Software in Autonomous Driving Systems T2 - Model-Based Safety and Assessment: 6th International Symposium, IMBSA 2019, Thessaloniki, Greece, October 16–18, 2019, Proceedings N2 - The increasing complexity of Advanced Driver Assistance Systems (ADAS) presents a challenging task to validate safe and reliable performance of these systems under varied conditions. The test and validation of ADAS/AD with real test drives, although important, involves huge costs and time. Simulation tools provide an alternative with the added advantage of reproducibility but often use ideal sensors, which do not reflect real sensor output accurately. This paper presents a new validation methodology using fault injection, as recommended by the ISO 26262 standard, to test software and system robustness. In our work, we investigated and developed a tool capable of inserting faults at different software and system levels to verify its robustness. The scope of this paper is to cover the fault injection test for the Visteon’s DriveCore™ system, a centralized domain controller for Autonomous driving which is sensor agnostic and SoC agnostic. With this new approach, the validation of safety monitoring functionality and its behavior can be tested using real-world data instead of synthetic data from simulation tools resulting in having better confidence in system performance before proceeding with in-vehicle testing. KW - Advanced driver assistance systems (ADAS/AD) KW - ISO 26262 KW - Safety-critical systems validation KW - Safety of the intended functionality (SOTIF) Y1 - 2019 SN - 978-3-030-32872-6 U6 - https://doi.org/10.1007/978-3-030-32872-6_20 SP - 303 EP - 316 PB - Springer CY - Cham ER - TY - JOUR A1 - Reger, Vitali A1 - Kuhnhenne, Markus A1 - Hachul, Helmut A1 - Döring, Bernd A1 - Blanke, Tobias A1 - Göttsche, Joachim T1 - Plusenergiegebäude 2.0 in Stahlleichtbauweise JF - Stahlbau Y1 - 2019 U6 - https://doi.org/10.1002/stab.201900034 SN - 1437-1049 (E-journal), 0038-9145 (print) VL - 88 IS - 6 SP - 522 EP - 528 PB - Ernst & Sohn CY - Berlin ER - TY - GEN A1 - Reiswich, Martin A1 - Brandt, Hannes A1 - Czupalla, Markus T1 - Passive thermal control by integration of phase change material into additively manufactured structures T2 - E2. 47th Student conference N2 - Optical Instruments require an extremely stable thermal surrounding to prevent loss of data quality by misalignments of the instrument components resulting from material deformation due to temperature f luctuations (e.g. from solar intrusion). Phase Change Material (PCM) can be applied as a thermal damper to achieve a more uniform temperature distribution. The challenge of this method is, among others, the integration of PCM into affected areas. If correctly designed, incoming heat is latently absorbed during phase change of the PCM, i.e. the temperature of a structure remains almost constant. In a cold phase, the heat during phase change is released again latently until the PCM returns to its original state of aggregation. Thus, the structure is thermally stabilized. At FH Aachen– University of Applied Sciences research is conducted to apply PCM directly into the structures of affected components (baffles, optical benches, electronic boxes, etc.). Through the application of Additive Manufacturing, the necessary voids are directly printed into these structures and filled later with PCM. Additive Manufacturing enables complex structures that would not have been possible with conservative manufacturing methods. A corresponding Breadboard was developed and manufactured by Selective Laser Melting (SLM). The current state of research includes the handling and analysis of the Breadboard, tests and a correlation of the thermal model. The results have shown analytically and practically that it is possible to use PCM as an integral part of the structure as a thermal damper. The results serve as a basis for the further development of the technology, which should maximize performance and enable the integration of PCM into much more complex structures. Y1 - 2019 N1 - 70th International Astronautical Congress, 21. - 25. Oktober 2019, Washington D.C., United States ER - TY - JOUR A1 - Rietsch, Stefan H. G. A1 - Brunheim, Sascha A1 - Orzada, Stephan A1 - Voelker, Maximilian N. A1 - Maderwald, Stefan A1 - Bitz, Andreas A1 - Gratz, Marcel A1 - Ladd, Mark E. A1 - Quick, Harald H. T1 - Development and evaluation of a 16-channel receive-only RF coil to improve 7T ultra-high field body MRI with focus on the spine JF - Magnetic Resonance in Medicine Y1 - 2019 U6 - https://doi.org/10.1002/mrm.27731 SN - 1522-2594 IS - Early view PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Rings, René A1 - Ludowicy, Jonas A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - Sensitivity Analysis of General Aviation Aircraft with Parallel Hybrid-Electric Propulsion Systems T2 - Asia Pacific International Symposium on Aerospace Technology. APISAT 2019 Y1 - 2019 ER - TY - JOUR A1 - Roeth, A.A. A1 - Slabu, I. A1 - Kessler, A. A1 - Engelmann, Ulrich M. T1 - Local treatment of pancreatic cancer with magnetic nanoparticles JF - HPB Y1 - 2019 U6 - https://doi.org/10.1016/j.hpb.2019.10.959 SN - 1365-182X VL - 21 IS - Supplement 3 SP - S868 EP - S869 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Rossi, Leonardo A1 - Holtschoppen, Britta A1 - Butenweg, Christoph T1 - Official data on the economic consequences of the 2012 Emilia-Romagna earthquake: a first analysis of database SFINGE JF - Bulletin of Earthquake Engineering Y1 - 2019 U6 - https://doi.org/10.1007%2Fs10518-019-00655-8 VL - 17 IS - 9 SP - 4855 EP - 4884 PB - Springer CY - Berlin ER - TY - JOUR A1 - Rossi, Leonardo A1 - Parisi, Davide A1 - Casari, Chiara A1 - Montanari, Luca A1 - Ruggieri, Gabriella A1 - Holtschoppen, Britta A1 - Butenweg, Christoph T1 - Empirical Data about Direct Economic Consequences of Emilia-Romagna 2012 Earthquake on Long-Span-Beam Buildings JF - Earthquake Spectra Y1 - 2019 U6 - https://doi.org/10.1193/100118EQS224DP SN - 1944-8201 VL - 35 IS - 4 SP - 1979 EP - 2001 ER - TY - JOUR A1 - Rossi, Leonardo A1 - Stupazzini, Marco A1 - Parisi, Davide A1 - Holtschoppen, Britta A1 - Ruggieri, Gabriella A1 - Butenweg, Christoph T1 - Empirical fragility functions and loss curves for long-span-beam buildings based on the 2012 Emilia-Romagna earthquake official database JF - Bulletin of Earthquake Engineering N2 - The 2012 Emilia-Romagna earthquake, that mainly struck the homonymous Italian region provoking 28 casualties and damage to thousands of structures and infrastructures, is an exceptional source of information to question, investigate, and challenge the validity of seismic fragility functions and loss curves from an empirical standpoint. Among the most recent seismic events taking place in Europe, that of Emilia-Romagna is quite likely one of the best documented, not only in terms of experienced damages, but also for what concerns occurred losses and necessary reconstruction costs. In fact, in order to manage the compensations in a fair way both to citizens and business owners, soon after the seismic sequence, the regional administrative authority started (1) collecting damage and consequence-related data, (2) evaluating information sources and (3) taking care of the cross-checking of various reports. A specific database—so-called Sistema Informativo Gestione Europa (SFINGE)—was devoted to damaged business activities. As a result, 7 years after the seismic events, scientists can rely on a one-of-a-kind, vast and consistent database, containing information about (among other things): (1) buildings’ location and dimensions, (2) occurred structural damages, (3) experienced direct economic losses and (4) related reconstruction costs. The present work is focused on a specific data subset of SFINGE, whose elements are Long-Span-Beam buildings (mostly precast) deployed for business activities in industry, trade or agriculture. With the available set of data, empirical fragility functions, cost and loss ratio curves are elaborated, that may be included within existing Performance Based Earthquake Engineering assessment toolkits. KW - Empirical fragility functions KW - Empirical consequence curves KW - Precast buildings KW - Emilia-Romagna earthquake KW - PBEE Y1 - 2019 U6 - https://doi.org/10.1007/s10518-019-00759-1 SN - 1573-1456 VL - 18 SP - 1693 EP - 1721 PB - Springer Nature ER - TY - JOUR A1 - Rupp, Matthias A1 - Handschuh, Nils A1 - Rieke, Christian A1 - Kuperjans, Isabel T1 - Contribution of country-specific electricity mix and charging time to environmental impact of battery electric vehicles: A case study of electric buses in Germany JF - Applied Energy Y1 - 2019 U6 - https://doi.org/10.1016/j.apenergy.2019.01.059 SN - 0306-2619 VL - 237 SP - 618 EP - 634 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Sadeghfam, Arash A1 - Sadeghi-Ahangar, A. A1 - Elgamal, Abdelrahman A1 - Heuermann, Holger T1 - Design and Development of a Novel Self-Igniting Microwave Plasma Jet for Industrial Applications T2 - IEEE MTT-S International Microwave Symposium Digest Y1 - 2019 SN - 978-172811309-8 SP - 63 EP - 66 ER - TY - JOUR A1 - Sagymbay, Altynay A1 - G.E., Nusupbaeva A1 - N.Zh, Tleumbetova A1 - A.S., Mutalieva A1 - Nurpeisova, Ainur A1 - D.B., Jussupova A1 - Digel, Ilya T1 - Molecular genetics features of the epidemic season 2017-2018 on the influenza in Kazakhstan JF - Eurasian Journal of Ecology Y1 - 2019 SN - 2617-7358 VL - 58 IS - 1 SP - 50 EP - 60 ER - TY - CHAP A1 - Sattler, Johannes, Christoph A1 - Alexopoulos, Spiros A1 - Caminos, Ricardo Alexander Chico A1 - Mitchell, John C. A1 - Ruiz, Victor C. A1 - Kalogirou, Soteris A1 - Ktistis, Panayiotis K. A1 - Teixeira Boura, Cristiano José A1 - Herrmann, Ulf T1 - Dynamic simulation model of a parabolic trough collector system with concrete thermal energy storage for process steam generation T2 - AIP Conference Proceedings Y1 - 2019 U6 - https://doi.org/10.1063/1.5117663 SN - 0094243X VL - 2126 SP - 150007-1 EP - 150007-8 ER - TY - JOUR A1 - Savitskaya, I.S. A1 - Kistaubayeva, A.S. A1 - Ignatova, L.V. A1 - Digel, Ilya T1 - Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells JF - Heliyon Y1 - 2019 U6 - https://doi.org/10.1016/j.heliyon.2019.e02592 SN - 2405-8440 VL - 5 IS - 10 SP - Artikelnummer e02592 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schael, S. A1 - Atanasyan, A. A1 - Berdugo, J. A1 - Bretz, T. A1 - Czupalla, Markus A1 - Dachwald, Bernd A1 - Doetinchem, P. von A1 - Duranti, M. A1 - Gast, H. A1 - Karpinski, W. A1 - Kirn, T. A1 - Lübelsmeyer, K. A1 - Maña, C. A1 - Marrocchesi, P.S. A1 - Mertsch, P. A1 - Moskalenko, I.V. A1 - Schervan, T. A1 - Schluse, M. A1 - Schröder, K.-U. A1 - Schultz von Dratzig, A. A1 - Senatore, C. A1 - Spies, L. A1 - Wakely, S.P. A1 - Wlochal, M. A1 - Uglietti, D. A1 - Zimmermann, J. T1 - AMS-100: The next generation magnetic spectrometer in space – An international science platform for physics and astrophysics at Lagrange point 2 JF - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment Y1 - 2019 U6 - https://doi.org/10.1016/j.nima.2019.162561 SN - 0168-9002 VL - 944 IS - 162561 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Scheer, Nico A1 - Henderson, Colin James A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Mclaren, Aileen W. A1 - MacLeod, Alastair Kenneth A1 - Lin, De A1 - Wright, Jayne A1 - Stanley, Lesley A1 - Wolf, C. Roland T1 - An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials JF - Drug Metabolism and Disposition Y1 - 2019 U6 - https://doi.org/10.1124/dmd.119.086397 IS - Early view ER - TY - JOUR A1 - Schiedermeier, Maximilian A1 - Rettner, Cornelius A1 - Heilmann, Marcel A1 - Schneider, Felix A1 - Marz, Martin T1 - Interference of automotive HV-DC-systems by traction voltage-source-inverters (VSI) JF - 2019 IEEE Transportation Electrification Conference (ITEC-India) Y1 - 2019 U6 - https://doi.org/10.1109/ITEC-India48457.2019.ITECINDIA2019-37 SP - 1 EP - 6 PB - IEEE CY - New York ER - TY - JOUR A1 - Schieren, Mark A1 - Kleinschmidt, Joris A1 - Schmutz, Axel A1 - Loop, Torsten A1 - Gatzweiler, Karl-Heinz A1 - Staat, Manfred A1 - Wappler, Frank A1 - Defosse, Jerome T1 - Comparison of forces acting on maxillary incisors during tracheal intubation with different laryngoscopy techniques: a blinded manikin study JF - Anaesthesia Y1 - 2019 SN - 1365-2044 U6 - https://doi.org/10.1111/anae.14815 N1 - Die Anhänge "Table S1 (Impact of sex and level of training on dental force. Results presented as median (IQR [range]) and n (%))" und "Appendix S1 (Measurement technique.)" stehen unter "Supporting Information" zum Download bereit. VL - 74 IS - 12 PB - Wiley-Blackwell CY - Oxford ER -