TY  - JOUR
A1  - Ziemons, Karl
A1  - Achten, R.
A1  - Auffray, E.
A1  - Müller-Veggian, Mattea
T1  - The ClearPET™ neuro scanner: a dedicated LSO/LuYAP phoswich small animal PET scanner
JF  - 2004 IEEE Nuclear Science Symposium conference record : Nuclear Science Symposium, Medical Imaging Conference ; 16 - 22 October 2004, Rome, Italy ; [including the Symposium on Nuclear Power System (SNPS), 14th Room Temperature Semiconductor X- and Gamma-Ray Detectors Workshop and special focus workshops] / NPSS, Nuclear & Plasma Sciences Society. Guest ed.: J. Anthony Seibert
Y1  - 2004
SN  - 1082-3654
N1  - Nuclear Science Symposium Conference Record, 2004 IEEE
SP  - 2430
EP  - 2433
PB  - IEEE Operations Center
CY  - Piscataway, NJ
ER  - 
TY  - JOUR
A1  - Ziemons, Karl
T1  - Jet production and fragmentation properties in deep inelastic muon scattering
JF  - Zeitschrift für Physik C :  Particles and Fields
Y1  - 1987
SN  - 0170-9739
N1  - European Muon Collaboration
VL  - 36
IS  - 4
SP  - 527
EP  - 543
ER  - 
TY  - JOUR
A1  - Ziemons, Karl
T1  - A measurement of the spin asymmetry of the structure function g1 in deep inelastic muon-proton scattering
JF  - Physics Letters B
N2  - The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by longitudinally polarised protons has been measured over a large x range (0.01<x<0.7). The spin-dependent structure function g1(x) for the proton has been determined and its integral over x found to be 0.114±0.012±0.026, in disagreement with the Ellis-Jaffe sum rule. Assuming the validity of the Bjorken sum rule, this result implies a significant negative value for the integral of g1 for the neutron. These values for the integrals of g1 lead to the conclusion that the total quark spin constitutes a rather small fraction of the spin of the nucleon.
Y1  - 1988
SN  - 0370-2693
N1  - European Muon Collaboration
VL  - 206
IS  - 2
SP  - 364
EP  - 370
ER  - 
TY  - JOUR
A1  - Ziemons, Karl
T1  - An investigation of the spin structure of the proton in deep inelastic scattering of polarised muons and polarised protons
JF  - Nuclear Physics B
N2  - The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by longitudinally polarised protons has been measured in the range 0.01<×<0.7. The spin dependent structure function g1(x) for the proton has been determined and, combining the data with earlier SLAC measurements, its integral over x found to be 0.126±0.010(stat.)±0.015(syst.), in disagreement with the Ellis-Jaffe sum rule. Assuming the validity of the Biorken sum rule, this result implies a significant negative value for the integral of g1 for the neutron. These integrals lead to the conclusion, in the naïve quark parton model, that the total quark spin constitutes a rather small fraction of the spin of the nucleon. Results are also presented on the asymmetries in inclusive hadron production which are consistent with the above picture.
Y1  - 1989
SN  - 0550-3213
N1  - European Muon Collaboration
VL  - 328
IS  - 1
SP  - 1
EP  - 35
ER  - 
TY  - JOUR
A1  - Ziemons, Karl
T1  - Comparison of forward hadrons produced in muon interactions on nuclear targets and deuterium
JF  - Zeitschrift für Physik C Particles and Fields
N2  - Differential multiplicities of forward produced hadrons in deep inelastic muon scattering on nuclear targets have been compared with those from deuterium. The ratios are observed to increase towards unity as the virtual photon energy increases with no significant dependence on the other muon kinematic variables. The hadron transverse momentum distribution is observed to be broadened in nuclear targets. The dependence on the remaining hadron variables is investigated and the results are discussed in the framework of intranuclear interaction models and in the context of the EMC effect.
Y1  - 1991
SN  - 1431-5858
N1  - European Muon Collaboration
VL  - 52
IS  - 1
SP  - 1
EP  - 11
ER  - 
TY  - JOUR
A1  - Ziemons, Karl
T1  - Muoproduction of J/ψ and the gluon distribution of the nucleon
JF  - Zeitschrift für Physik C Particles and Fields
N2  - Measurements are presented of the inclusive distributions of the J/Ψ meson produced by muons of energy 200 GeV from an ammonia target. The gluon distribution of the nucleon has been derived from the data in the range 0.04<x<0.36 using a technique based on the colour singlet model. An arbitrary normalisation factor is required to obtain a reasonable integral of the gluon distribution. Some comments are made on the use of J/Ψ productionby virtual photons to extract the gluon distribution at HERA.
Y1  - 1992
SN  - 1431-5858
N1  - European Muon Collaboration
VL  - 56
IS  - 1
SP  - 21
EP  - 28
ER  - 
TY  - JOUR
A1  - Ziemons, Karl
T1  - A measurement of the ratio of the nucleon structure function in copper and deuterium
JF  - Zeitschrift für Physik C Particles and Fields
N2  - Results are presented on the ratios of the nucleon structure function in copper to deuterium from two separate experiments. The data confirm that the nucleon structure function,F 2, is different for bound nucleons than for the quasi-free ones in the deuteron. The redistribution in the fraction of the nucleon's momentum carried by quarks is investigated and it is found that the data are compatible with no integral loss of quark momenta due to nuclear effects.
Y1  - 1993
SN  - 1431-5858
N1  - European Muon Collaboration
VL  - 57
IS  - 2
SP  - 211
EP  - 218
ER  - 
TY  - JOUR
A1  - Zhubanova, Azhar A.
A1  - Digel, Ilya
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology
N2  - The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.
KW  - Clusterion
KW  - Raumluft
KW  - Luftreiniger
KW  - Plasmacluster ion technology
KW  - Air purification
Y1  - 2007
ER  - 
TY  - JOUR
A1  - Zhubanova, Azhar A.
A1  - Aknazarov, S. K.
A1  - Mansurov, Zulkhair
A1  - Digel, Ilya
A1  - Kozhalakova, A. A.
A1  - Akimbekov, Nuraly Shardarbekovich
A1  - O'Heras, Carlos
A1  - Tazhibayeva, S.
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials
N2  - Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment.
KW  - Kohlenstofffaser
KW  - Lipopolysaccharide
KW  - nanostrukturierte carbonisierte Pflanzenteile
KW  - lipopolysaccharides
KW  - nanostructured carbonized plant parts
Y1  - 2010
ER  - 
TY  - JOUR
A1  - Zhen, Manghao
A1  - Liang, Yunpei
A1  - Staat, Manfred
A1  - Li, Quanqui
A1  - Li, Jianbo
T1  - Discontinuous fracture behaviors and constitutive model of sandstone specimens containing non-parallel prefabricated fissures under uniaxial compression
JF  - Theoretical and Applied Fracture Mechanics
N2  - The deformation and damage laws of non-homogeneous irregular structural planes in rocks are the basis for studying the stability of rock engineering. To investigate the damage characteristics of rock containing non-parallel fissures, uniaxial compression tests and numerical simulations were conducted on sandstone specimens containing three non-parallel fissures inclined at 0°, 45° and 90° in this study. The characteristics of crack initiation and crack evolution of fissures with different inclinations were analyzed. A constitutive model for the discontinuous fractures of fissured sandstone was proposed. The results show that the fracture behaviors of fissured sandstone specimens are discontinuous. The stress–strain curves are non-smooth and can be divided into nonlinear crack closure stage, linear elastic stage, plastic stage and brittle failure stage, of which the plastic stage contains discontinuous stress drops. During the uniaxial compression test, the middle or ends of 0° fissures were the first to crack compared to 45° and 90° fissures. The end with small distance between 0° and 45° fissures cracked first, and the end with large distance cracked later. After the final failure, 0° fissures in all specimens were fractured, while 45° and 90° fissures were not necessarily fractured. Numerical simulation results show that the concentration of compressive stress at the tips of 0°, 45° and 90° fissures, as well as the concentration of tensile stress on both sides, decreased with the increase of the inclination angle. A constitutive model for the discontinuous fractures of fissured sandstone specimens was derived by combining the logistic model and damage mechanic theory. This model can well describe the discontinuous drops of stress and agrees well with the whole processes of the stress–strain curves of the fissured sandstone specimens.
KW  - Constitutive model
KW  - Damage mechanics theory
KW  - Discontinuous fractures
KW  - Uniaxial compression test
KW  - Non-parallel fissures
Y1  - 2024
U6  - http://dx.doi.org/10.1016/j.tafmec.2024.104373
SN  - 0167-8442
VL  - 131
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Zhantlessova, Sirina
A1  - Savitskaya, Irina
A1  - Kistaubayeva, Aida
A1  - Ignatova, Ludmila
A1  - Talipova, Aizhan
A1  - Pogrebnjak, Alexander
A1  - Digel, Ilya
T1  - Advanced “Green” prebiotic composite of bacterial cellulose/pullulan based on synthetic biology-powered microbial coculture strategy
JF  - Polymers
N2  - Bacterial cellulose (BC) is a biopolymer produced by different microorganisms, but in biotechnological practice, Komagataeibacter xylinus is used. The micro- and nanofibrillar structure of BC, which forms many different-sized pores, creates prerequisites for the introduction of other polymers into it, including those synthesized by other microorganisms. The study aims to develop a cocultivation system of BC and prebiotic producers to obtain BC-based composite material with prebiotic activity. In this study, pullulan (PUL) was found to stimulate the growth of the probiotic strain Lactobacillus rhamnosus GG better than the other microbial polysaccharides gellan and xanthan. BC/PUL biocomposite with prebiotic properties was obtained by cocultivation of Komagataeibacter xylinus and Aureobasidium pullulans, BC and PUL producers respectively, on molasses medium. The inclusion of PUL in BC is proved gravimetrically by scanning electron microscopy and by Fourier transformed infrared spectroscopy. Cocultivation demonstrated a composite effect on the aggregation and binding of BC fibers, which led to a significant improvement in mechanical properties. The developed approach for “grafting” of prebiotic activity on BC allows preparation of environmentally friendly composites of better quality.
KW  - coculture
KW  - pullulan
KW  - exopolysaccharides
KW  - prebiotic
KW  - bacterial cellulose
Y1  - 2022
U6  - http://dx.doi.org/10.3390/polym14153224
SN  - 2073-4360
N1  - This article belongs to the Special Issue "Cellulose Based Composites"
VL  - 14
IS  - 15
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Zhang, Jin
A1  - Heimbach, Tycho
A1  - Scheer, Nico
A1  - Barve, Avantika
A1  - Li, Wenkui
A1  - Lin, Wen
A1  - He, Handan
T1  - Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4–Humanized Mouse Studies With PBPK Modeling
JF  - Journal of Pharmaceutical Sciences
N2  - NVS123 is a poorly water-soluble protease 56 inhibitor in clinical development. Data from in vitro hepatocyte studies suggested that NVS123 is mainly metabolized by CYP3A4. As a consequence of limited solubility, NVS123 therapeutic plasma exposures could not be achieved even with high doses and optimized formulations. One approach to overcome NVS123 developability issues was to increase plasma exposure by coadministrating it with an inhibitor of CYP3A4 such as ritonavir. A clinical boost effect was predicted by using physiologically based pharmacokinetic (PBPK) modeling. However, initial boost predictions lacked sufficient confidence because a key parameter, fraction of drug metabolized by CYP3A4 (ƒₘCYP3A4), could not be estimated with accuracy on account of disconnects between in vitro and in vivo preclinical data. To accurately estimate ƒₘCYP3A4 in human, an in vivo boost effect study was conducted using CYP3A4-humanized mouse model which showed a 33- to 56-fold exposure boost effect. Using a top-down approach, human ƒₘCYP3A4 for NVS123 was estimated to be very high and included in the human PBPK modeling to support subsequent clinical study design. The combined use of the in vivo boost study in CYP3A4-humanized mouse model mice along with PBPK modeling accurately predicted the clinical outcome and identified a significant NVS123 exposure boost (∼42-fold increase) with ritonavir.
Y1  - 2016
U6  - http://dx.doi.org/doi.org/10.1016/j.xphs.2016.01.021
SN  - 0022-3549
VL  - Volume 105
IS  - Issue 4
SP  - 1398
EP  - 1404
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Zhang, G.
A1  - Valero, Daniel
A1  - Bung, Daniel B.
A1  - Chanson, H.
T1  - On the estimation of free-surface turbulence using ultrasonic sensors
JF  - Flow Measurement and Instrumentation
N2  - Accurate determination of free-surface dynamics has attracted much research attention during the past decade and has important applications in many environmental and water related areas. In this study, the free-surface dynamics in several turbulent flows commonly found in nature were investigated using a synchronised setup consisting of an ultrasonic sensor and a high-speed video camera. Basic sensor capabilities were examined in dry conditions to allow for a better characterisation of the present sensor model. The ultrasonic sensor was found to adequately reproduce free-surface dynamics up to the second order, especially in two-dimensional scenarios with the most energetic modes in the low frequency range. The sensor frequency response was satisfactory in the sub-20 Hz band, and its signal quality may be further improved by low-pass filtering prior to digitisation. The application of the USS to characterise entrapped air in high-velocity flows is also discussed.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.flowmeasinst.2018.02.009
SN  - 0955-5986
VL  - 60
SP  - 171
EP  - 184
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Zerlin, Kay
A1  - Kasischke, Nicole
A1  - Digel, Ilya
A1  - Maggakis-Kelemen, Christina
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Kayser, Peter
A1  - Linder, Peter
A1  - Artmann, Gerhard
T1  - Structural transition temperature of hemoglobins correlates with species’ body temperature
JF  - European Biophysics Journal. 37 (2007), H. 1
Y1  - 2007
SN  - 1432-1017
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Zerlin, Kay
A1  - Digel, Ilya
A1  - Stadler, Andreas M.
A1  - Büldt, Georg
A1  - Zaccai, Guiseppe
A1  - Artmann, Gerhard
T1  - Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions
JF  - Regenerative medicine. 2 (2007), H. 5
Y1  - 2007
SN  - 1746-0751
N1  - Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany
SP  - 573
EP  - 573
ER  - 
TY  - JOUR
A1  - Zatko, B.
A1  - Dubecký, F.
A1  - Bohacek, P.
A1  - Gombia, E.
A1  - Frigeri, P.
A1  - Mosca, R.
A1  - Franchi, S.
A1  - Huarn, J.
A1  - Nescas, V.
A1  - Sekacova, M.
A1  - Förster, Arnold
A1  - Kordos, P.
T1  - On the spectrometric performance limit of radiation detectors based on semi-insulating GaAs
JF  - Nuclear instruments and methods in physics research, Section A. 531 (2004), H. 1-2
Y1  - 2004
SN  - 0168-9002
SP  - 111
EP  - 120
ER  - 
TY  - JOUR
A1  - Zastrow, Udo
A1  - Rieder, G.
T1  - Bracketing eigenvalues of an oscillating elastic body by integral equations
JF  - Bracketing of eigenfrequencies of continous structures : Euromech Colloquium, no. 112, Mátrafüred (Hungary), 21 - 23 February, 1979 / ed. by À. Bosznay
Y1  - 1980
SN  - 963-05-2625-5
N1  - Euromech Colloquium <112, 1979, Mátrafüred>
SP  - 421
EP  - 434
PB  - Akad. Kiadó
CY  - Budapest
ER  - 
TY  - JOUR
A1  - Zastrow, Udo
A1  - Panagiotopoulos, P. D.
T1  - An integral "Equation" approach to the unilateral contact problem
JF  - ZAMM - Zeitschrift für angewandte Mathematik und Mechanik. 59 (1979), H. 8
Y1  - 1979
SN  - 1521-4001
SP  - 392
EP  - 393
ER  - 
TY  - JOUR
A1  - Zastrow, Udo
A1  - Hackl, Klaus
T1  - On the existence, uniqueness and completeness of displacements and stress functions in linear elasticity  / Hackl, Klaus ; Zastrow, Udo
JF  - Journal of Elasticity. 19 (1988), H. 1
Y1  - 1988
SN  - 1573-2681
SP  - 3
EP  - 23
ER  - 
TY  - JOUR
A1  - Zastrow, Udo
T1  - On the formulation of the fundamental solutions for orthotropic plane elasticity
JF  - Acta Mechanica. 57 (1985), H. 3-4
Y1  - 1985
SN  - 1619-6937
SP  - 113
EP  - 122
ER  -