TY  - BOOK
A1  - Sander, Volker
T1  - Design and evaluation of a bandwidth broker that provides network quality of service for grid applications
Y1  - 2003
SN  - 3-00-010002-4
N1  - NIC series ; 16 ; Zugl. Aachen, Techn. Hochsch., Diss., 2002
PB  - John von Neumann Institute for Computing (NIC)
CY  - Jülich
ER  - 
TY  - BOOK
A1  - Sander, Volker
T1  - Optical Network Infrastructure for Grid / Simeonidou, Dimitra ... (ed.)
Y1  - 2004
N1  - GFD-I.036 Category: Informational ; GHPN-RG
PB  - Global Grid Forum
ER  - 
TY  - BOOK
A1  - Sander, Volker
T1  - Networking Issues for Grid Infrastructure / Sander, Volker  (ed.)
Y1  - 2004
N1  - GFD-I.037 Category: Informational ; Grid High Performance Networking Research Group
PB  - Global Grid Forum
ER  - 
TY  - CHAP
A1  - Sakthivel, Mariappan
A1  - Weppner, Werner
T1  - Response behaviour of a hydrogen sensor based on ionic conducting polymer-metal interfaces prepared by the chemical reduction method
N2  - A solid-state amperometric hydrogen sensor based on a protonated Nafion membrane and catalytic active electrode operating at room temperature was fabricated and tested. Ionic conducting polymer-metal electrode interfaces were prepared chemically by using the impregnation-reduction method. The polymer membrane was impregnated with tetra-ammine platinum chloride hydrate and the metal ions were subsequently reduced by using either sodium tetrahydroborate or potassium tetrahydroborate. The hydrogen sensing characteristics with air as reference gas is reported. The sensors were capable of detecting hydrogen concentrations from 10 ppm to 10% in nitrogen. The response time was in the range of 10-30 s and a stable linear current output was observed. The thin Pt films were characterized by XRD, Infrared Spectroscopy, Optical Microscopy, Atomic Force Microscopy, Scanning Electron Microscopy and EDAX.
KW  - Biosensor
KW  - Hydrogen sensor
KW  - amperometric sensor
KW  - porous Pt electrode
KW  - chemical reduction method
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1399
ER  - 
TY  - JOUR
A1  - Sadykov, Rustam
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Linder, Peter
A1  - Kayser, Peter
A1  - Artmann, Gerhard
A1  - Savitskaya, Irina
A1  - Zhubanova, Azhar
T1  - Oral lead exposure induces dysbacteriosis in rats
JF  - Journal of Occupational Health. 51 (2009) (2009), H. 1
Y1  - 2009
SN  - 1348-9585
SP  - 64
EP  - 73
ER  - 
TY  - JOUR
A1  - Rübbelke, Dirk
A1  - Vögele, Stefan
A1  - Grajewski, Matthias
A1  - Zobel, Luzy
T1  - Hydrogen-based steel production and global climate protection: An empirical analysis of the potential role of a European cross border adjustment mechanism
JF  - Journal of Cleaner Production
N2  - The European Union's aim to become climate neutral by 2050 necessitates ambitious efforts to reduce carbon emissions. Large reductions can be attained particularly in energy intensive sectors like iron and steel. In order to prevent the relocation of such industries outside the EU in the course of tightening environmental regulations, the establishment of a climate club jointly with other large emitters and alternatively the unilateral implementation of an international cross-border carbon tax mechanism are proposed. This article focuses on the latter option choosing the steel sector as an example. In particular, we investigate the financial conditions under which a European cross border mechanism is capable to protect hydrogen-based steel production routes employed in Europe against more polluting competition from abroad. By using a floor price model, we assess the competitiveness of different steel production routes in selected countries. We evaluate the climate friendliness of steel production on the basis of specific GHG emissions. In addition, we utilize an input-output price model. It enables us to assess impacts of rising cost of steel production on commodities using steel as intermediates. Our results raise concerns that a cross-border tax mechanism will not suffice to bring about competitiveness of hydrogen-based steel production in Europe because the cost tends to remain higher than the cost of steel production in e.g. China. Steel is a classic example for a good used mainly as intermediate for other products. Therefore, a cross-border tax mechanism for steel will increase the price of products produced in the EU that require steel as an input. This can in turn adversely affect competitiveness of these sectors. Hence, the effects of higher steel costs on European exports should be borne in mind and could require the cross-border adjustment mechanism to also subsidize exports.
Y1  - 2022
U6  - http://dx.doi.org/10.1016/j.jclepro.2022.135040
SN  - 0959-6526
VL  - 380
IS  - Part 2, Art. Nr.:135040
PB  - Elsevier
ER  - 
TY  - JOUR
A1  - Rübbelke, Dirk
A1  - Vögele, Stefan
A1  - Grajewski, Matthias
A1  - Zobel, Luzy
T1  - Cross border adjustment mechanism: Initial data for the assessment of hydrogen-based steel production
JF  - Data in Brief
N2  - Ambitious climate targets affect the competitiveness of industries in the international market. To prevent such industries from moving to other countries in the wake of increased climate protection efforts, cost adjustments may become necessary. Their design requires knowledge of country-specific production costs. Here, we present country-specific cost figures for different production routes of steel, paying particular attention to transportation costs. The data can be used in floor price models aiming to assess the competitiveness of different steel production routes in different countries (Rübbelke, 2022).
KW  - Energy-intensive industry
KW  - Steel industry
KW  - Competitiveness
KW  - Floor prices
KW  - Cross border adjustment mechanism
Y1  - 2023
U6  - http://dx.doi.org/10.1016/j.dib.2023.108907
SN  - 2352-3409
VL  - 47
IS  - Article 108907
SP  - 1
EP  - 5
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Röthenbacher, Annika
A1  - Cesari, Matteo
A1  - Doppler, Christopher E.J.
A1  - Okkels, Niels
A1  - Willemsen, Nele
A1  - Sembowski, Nora
A1  - Seger, Aline
A1  - Lindner, Marie
A1  - Brune, Corinna
A1  - Stefani, Ambra
A1  - Högl, Birgit
A1  - Bialonski, Stephan
A1  - Borghammer, Per
A1  - Fink, Gereon R.
A1  - Schober, Martin
A1  - Sommerauer, Michael
T1  - RBDtector: an open-source software to detect REM sleep without atonia according to visual scoring criteria
JF  - Scientific Reports
N2  - REM sleep without atonia (RSWA) is a key feature for the diagnosis of rapid eye movement (REM) sleep behaviour disorder (RBD). We introduce RBDtector, a novel open-source software to score RSWA according to established SINBAR visual scoring criteria. We assessed muscle activity of the mentalis, flexor digitorum superficialis (FDS), and anterior tibialis (AT) muscles. RSWA was scored manually as tonic, phasic, and any activity by human scorers as well as using RBDtector in 20 subjects. Subsequently, 174 subjects (72 without RBD and 102 with RBD) were analysed with RBDtector to show the algorithm’s applicability. We additionally compared RBDtector estimates to a previously published dataset. RBDtector showed robust conformity with human scorings. The highest congruency was achieved for phasic and any activity of the FDS. Combining mentalis any and FDS any, RBDtector identified RBD subjects with 100% specificity and 96% sensitivity applying a cut-off of 20.6%. Comparable performance was obtained without manual artefact removal. RBD subjects also showed muscle bouts of higher amplitude and longer duration. RBDtector provides estimates of tonic, phasic, and any activity comparable to human scorings. RBDtector, which is freely available, can help identify RBD subjects and provides reliable RSWA metrics.
Y1  - 2022
U6  - http://dx.doi.org/10.1038/s41598-022-25163-9
SN  - 2045-2322
VL  - 12
IS  - Article number: 20886
SP  - 1
EP  - 14
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Röhlen, Desiree
A1  - Pilas, Johanna
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
T1  - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid
JF  - Applied Biochemistry and Biotechnology
N2  - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates.
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s12010-017-2578-1
SN  - 1559-0291
VL  - 183
SP  - 566
EP  - 581
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Röhlen, Desiree
A1  - Pilas, Johanna
A1  - Dahmen, Markus
A1  - Keusgen, Michael
A1  - Selmer, Thorsten
A1  - Schöning, Michael Josef
T1  - Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes
JF  - Frontiers in Chemistry
N2  - Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes.
Y1  - 2018
U6  - http://dx.doi.org/10.3389/fchem.2018.00284
IS  - 6
PB  - Frontiers
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Rolka, David
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Integration of a capacitive EIS sensor into a FIA system for pH and penicillin determination
JF  - Sensors. 4 (2004)
Y1  - 2004
SN  - 1424-8220
SP  - 84
EP  - 94
ER  - 
TY  - JOUR
A1  - Roeth, A.A.
A1  - Slabu, I.
A1  - Kessler, A.
A1  - Engelmann, Ulrich M.
T1  - Local treatment of pancreatic cancer with magnetic nanoparticles
JF  - HPB
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.hpb.2019.10.959
SN  - 1365-182X
VL  - 21
IS  - Supplement 3
SP  - S868
EP  - S869
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Rodrigues, Raul T.
A1  - Morais, Paulo V.
A1  - Nordi, Cristina S. F.
A1  - Schöning, Michael Josef
A1  - Siqueira Jr., José R.
A1  - Caseli, Luciano
T1  - Carbon Nanotubes and Algal Polysaccharides To Enhance the Enzymatic Properties of Urease in Lipid Langmuir-Blodgett Films
JF  - Langmuir
N2  - Algal polysaccharides (extracellular polysaccharides) and carbon nanotubes (CNTs) were adsorbed on dioctadecyldimethylammonium bromide Langmuir monolayers to serve as a matrix for the incorporation of urease. The physicochemical properties of the supramolecular system as a monolayer at the air–water interface were investigated by surface pressure–area isotherms, surface potential–area isotherms, interfacial shear rheology, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to hydrophilic solid supports, quartz, mica, or capacitive electrolyte–insulator–semiconductor (EIS) devices, through the Langmuir–Blodgett (LB) technique, forming mixed films, which were investigated by quartz crystal microbalance, fluorescence spectroscopy, and field emission gun scanning electron microscopy. The enzyme activity was studied with UV–vis spectroscopy, and the feasibility of the thin film as a urea sensor was essayed in an EIS sensor device. The presence of CNT in the enzyme–lipid LB film not only tuned the catalytic activity of urease but also helped to conserve its enzyme activity. Viability as a urease sensor was demonstrated with capacitance–voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results are related to the synergism between the compounds on the active layer, leading to a surface morphology that allowed fast analyte diffusion owing to an adequate molecular accommodation, which also preserved the urease activity. This work demonstrates the feasibility of employing LB films composed of lipids, CNT, algal polysaccharides, and enzymes as EIS devices for biosensing applications.
Y1  - 2018
U6  - http://dx.doi.org/10.1021/acs.langmuir.7b04317
SN  - 1520-5827
VL  - 34
IS  - 9
SP  - 3082
EP  - 3093
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Rittweger, Jörn
A1  - Albracht, Kirsten
A1  - Flück, Martin
A1  - Ruoss, Severin
A1  - Brocca, Lorenza
A1  - Longa, Emanuela
A1  - Moriggi, Manuela
A1  - Seynnes, Olivier
A1  - Di Giulio, Irene
A1  - Tenori, Leonardo
A1  - Vignoli, Alessia
A1  - Capri, Miriam
A1  - Gelfi, Cecilia
A1  - Luchinat, Claudio
A1  - Franceschi, Claudio
A1  - Bottinelli, Roberto
A1  - Cerretelli, Paolo
A1  - Narici, Marco
T1  - Sarcolab pilot study into skeletal muscle’s adaptation to longterm spaceflight
JF  - npj Microgravity
Y1  - 2018
U6  - http://dx.doi.org/10.1038/s41526-018-0052-1
SN  - 2373-8065
VL  - 4
IS  - 1
SP  - 1
EP  - 9
PB  - Nature Portfolio
ER  - 
TY  - INPR
A1  - Ringers, Christa
A1  - Bialonski, Stephan
A1  - Solovev, Anton
A1  - Hansen, Jan N.
A1  - Ege, Mert
A1  - Friedrich, Benjamin M.
A1  - Jurisch-Yaksi, Nathalie
T1  - Preprint: Local synchronization of cilia and tissue-scale cilia alignment are sufficient for global metachronal waves
T2  - bioRxiv
N2  - Motile cilia are hair-like cell extensions present in multiple organs of the body. How cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine here experiments, novel analysis tools, and theory to address this knowledge gap. We investigate collective dynamics of cilia in the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Despite the fact that synchronization is local only, we observed global patterns of traveling metachronal waves across the multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right nose, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment are sufficient to generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping.
Y1  - 2021
U6  - http://dx.doi.org/10.1101/2021.11.23.469646
N1  - Veröffentlicht in eLife 12:e77701 (https://doi.org/10.7554/eLife.77701).
ER  - 
TY  - JOUR
A1  - Ringers, Christa
A1  - Bialonski, Stephan
A1  - Ege, Mert
A1  - Solovev, Anton
A1  - Hansen, Jan Niklas
A1  - Jeong, Inyoung
A1  - Friedrich, Benjamin M.
A1  - Jurisch-Yaksi, Nathalie
T1  - Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia
JF  - eLife
N2  - Motile cilia are hair-like cell extensions that beat periodically to generate fluid flow along various epithelial tissues within the body. In dense multiciliated carpets, cilia were shown to exhibit a remarkable coordination of their beat in the form of traveling metachronal waves, a phenomenon which supposedly enhances fluid transport. Yet, how cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine experiments, novel analysis tools, and theory to address this knowledge gap. To investigate collective dynamics of cilia, we studied zebrafish multiciliated epithelia in the nose and the brain. We focused mainly on the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Even though synchronization is local only, we observed global patterns of traveling metachronal waves across the zebrafish multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right noses, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions, i.e., cilia colliding with each other, and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment coincide and generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping.
Y1  - 2023
U6  - http://dx.doi.org/10.7554/eLife.77701
SN  - 2050-084X
VL  - 12
PB  - eLife Sciences Publications
ER  - 
TY  - JOUR
A1  - Riemer, A.
A1  - Schroth, P.
A1  - Schütz, S.
A1  - Hummel, Hans E.
A1  - Lüth, H.
A1  - Kohl, C.-D.
A1  - Schöning, Michael Josef
T1  - The future of fire detection: Biological sensors? – Die Zukunft der Brandgassensorik: Biologische Sensoren?
JF  - Gassensorik in der Brandmeldetechnik : [VdS-Fachtagung, am 15. und 16. November 2000 in Köln] = Gas sensors for fire detection / VdS Schadenverhütung
Y1  - 2000
N1  - Fachtagung Gassensorik in der Brandmeldetechnik ; (2000, Köln)
SP  - 1
EP  - 7
PB  - VdS Schadenverhütung
CY  - Köln
ER  - 
TY  - JOUR
A1  - Riedel, Marc
A1  - Kartchemnik, Julia
A1  - Schöning, Michael Josef
A1  - Lisdat, Fred
T1  - Impedimetric DNA detection – steps forward to sensorial application
JF  - Analytical chemistry
N2  - This study describes a label-free impedimetric sensor based on short ssDNA recognition elements for the detection of hybridization events. We concentrate on the elucidation of the influence of target length and recognition sequence position on the sensorial performance. The impedimetric measurements are performed in the presence of the redox system ferri-/ferrocyanide and show an increase in charge transfer resistance upon hybridization of ssDNA to the sensor surface. Investigations on the impedimetric signal stability demonstrate a clear influence of the buffers used during the sensor preparation and the choice of the passivating mercaptoalcanol compound. A stable sensor system has been developed, enabling a reproducible detection of 25mer target DNA in the low nanomolar range. After hybridization, a sensor regeneration can be reached with deionized water by adjustment of effective convection conditions, ensuring a sensor reusability. By investigations of longer targets with overhangs exposed to the solution, we can demonstrate applicability of the impedimetric detection for longer ssDNA. However, a decreasing charge transfer resistance change (ΔRct) is found by extending the overhang. As a strategy to increase the impedance change for longer target strands, the position of the recognition sequence can be designed in a way that a small overhang is exposed to the electrode surface. This is found to result in an increase in the relative Rct change. These results suggest that DNA and consequently negative charge near the electrode possess a larger impact on the impedimetric signal than DNA further away.
Y1  - 2014
U6  - http://dx.doi.org/10.1021/ac501800q
SN  - 1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)
VL  - 86 (2014)
IS  - 15
SP  - 7867
EP  - 7874
PB  - ACS Publications
CY  - Columbus
ER  - 
TY  - JOUR
A1  - Richter, Charlotte
A1  - Braunstein, Björn
A1  - Stäudle, Benjamin
A1  - Attias, Julia
A1  - Süss, Alexander
A1  - Weber, Tobias
A1  - Mileva, Katya N.
A1  - Rittweger, Jörn
A1  - Green, David A.
A1  - Albracht, Kirsten
T1  - Gastrocnemius medialis contractile behavior during running differs between simulated Lunar and Martian gravities
JF  - Scientific reports
N2  - The international partnership of space agencies has agreed to proceed forward to the Moon sustainably. Activities on the Lunar surface (0.16 g) will allow crewmembers to advance the exploration skills needed when expanding human presence to Mars (0.38 g). Whilst data from actual hypogravity activities are limited to the Apollo missions, simulation studies have indicated that ground reaction forces, mechanical work, muscle activation, and joint angles decrease with declining gravity level. However, these alterations in locomotion biomechanics do not necessarily scale to the gravity level, the reduction in gastrocnemius medialis activation even appears to level off around 0.2 g, while muscle activation pattern remains similar. Thus, it is difficult to predict whether gastrocnemius medialis contractile behavior during running on Moon will basically be the same as on Mars. Therefore, this study investigated lower limb joint kinematics and gastrocnemius medialis behavior during running at 1 g, simulated Martian gravity, and simulated Lunar gravity on the vertical treadmill facility. The results indicate that hypogravity-induced alterations in joint kinematics and contractile behavior still persist between simulated running on the Moon and Mars. This contrasts with the concept of a ceiling effect and should be carefully considered when evaluating exercise prescriptions and the transferability of locomotion practiced in Lunar gravity to Martian gravity.
KW  - Bone quality and biomechanics
KW  - Environmental impact
KW  - Skeletal muscle
KW  - Tendons
KW  - Ultrasound
Y1  - 2021
U6  - http://dx.doi.org/10.1038/s41598-021-00527-9
SN  - 2045-2322
N1  - Corresponding author: Charlotte Richter
VL  - 11
IS  - Article number: 22555
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Richter, Charlotte
A1  - Braunstein, Bjoern
A1  - Winnard, Andrew
A1  - Nasser, Mona
A1  - Weber, T.
T1  - Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review
JF  - Frontiers in physiology
Y1  - 2017
U6  - http://dx.doi.org/10.3389/fphys.2017.00583
IS  - 8, article 583
ER  -