TY - JOUR A1 - Smith, Wayne A1 - Kotliar, Konstantin A1 - Lammertyn, Leandi A1 - Ramoshaba, Nthai E. A1 - Vilser, Walthard A1 - Huisman, Hugo W. A1 - Schutte, Aletta E. T1 - Retinal vessel caliber and caliber responses in true normotensive black and white adults: The African-PREDICT study JF - Microvascular Research N2 - Purpose Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis of systemic vascular diseases, but it is unclear whether retinal vessel calibers and acute retinal vessel functional responses differ between young healthy black and white adults. Methods We included 112 black and 143 white healthy normotensive adults (20–30 years). Retinal vessel calibers (central retinal artery and vein equivalent (CRAE and CRVE)) were calculated from retinal images and vessel caliber responses to flicker light induced provocation (FLIP) were determined. Additionally, ambulatory blood pressure (BP), anthropometry and blood samples were collected. Results The groups displayed similar 24 h BP profiles and anthropometry (all p > .24). Black participants demonstrated a smaller CRAE (158 ± 11 vs. 164 ± 11 MU, p < .001) compared to the white group, whereas CRVE was similar (p = .57). In response to FLIP, artery maximal dilation was greater in the black vs. white group (5.6 ± 2.1 vs. 3.3 ± 1.8%; p < .001). Conclusions Already at a young age, healthy black adults showed narrower retinal arteries relative to the white population. Follow-up studies are underway to show if this will be related to increased risk for hypertension development. The reason for the larger vessel dilation responses to FLIP in the black population is unclear and warrants further investigation. Y1 - 2020 U6 - http://dx.doi.org/10.1016/j.mvr.2019.103937 SN - 0026-2862 VL - 128 IS - Article 103937 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Smith, Walker O. A1 - Baumann, Marcus A1 - Wilson, David L. A1 - Aletsee, Ludwig T1 - Phytoplankton biomass and productivity in the marginal ice zone of the Fram Strait during summer 1984 JF - Journal of geophysical research Y1 - 1987 SN - 2156-2202 (E-Journal); 2169-9291 (E-Journal); 0148-0227 (Print); 2169-9275 (Print) VL - Vol. 92 IS - Iss. C7 SP - 6777 EP - 6786 ER - TY - JOUR A1 - Slabu, Ioana A1 - Roeth, Anjali A. A1 - Engelmann, Ulrich M. A1 - Wiekhorst, Frank A1 - Buhl, Eva M. A1 - Neumann, Ulf P. A1 - Schmitz-Rode, Thomas T1 - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro JF - Nanotechnology Y1 - 2019 U6 - http://dx.doi.org/10.1088/1361-6528/ab033e SN - 1361-6528 VL - 30 IS - 18 SP - 184004 ER - TY - CHAP A1 - Sirazitdinova, Y. A1 - Dulzon, A. A1 - Müller, Burghard T1 - Project management practices in engineering university T2 - 21st International Conference for Students and Young Scientists: Modern Technique and Technologies, MTT 2015; National Research Tomsk Polytechnic UniversityTomsk; Russian Federation; 5 October 2015 through 9 October 2015 Y1 - 2015 U6 - http://dx.doi.org/10.1088/1757-899X/93/1/012080 N1 - IOP Conference Series: Materials Science and Engineering Vol. 93, Issue 1 ER - TY - JOUR A1 - Siqueira, José R. Jr. A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Zucolotto, Valtencir A1 - Oliveira, Osvaldo N. Jr. A1 - Schöning, Michael Josef T1 - Associating biosensing properties with the morphological structure of multilayers containing carbon nanotubes on field-effect devices JF - Physica status solidi (a). 207 (2010), H. 4 Y1 - 2010 SN - 1862-6300 N1 - Special Issue: Engineering of Functional Interfaces EnFI 2009 SP - 781 EP - 786 ER - TY - JOUR A1 - Siqueira, José R. Jr. A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Zucolotto, Valtencir A1 - Oliveira, Osvaldo N. Jr. A1 - Schöning, Michael Josef T1 - Penicillin biosensor based on a capacitive field-effect structure functionalized with a dendrimer/carbon nanotube multilayer JF - Biosensors and Bioelectronics. 25 (2009), H. 2 Y1 - 2009 SN - 0956-5663 SP - 497 EP - 501 ER - TY - JOUR A1 - Siqueira, José R. Jr. A1 - Abouzar, Maryam H. A1 - Bäcker, Matthias A1 - Zucolotto, Valtencir A1 - Poghossian, Arshak A1 - Oliveira, Osvaldo N. Jr. A1 - Schöning, Michael Josef T1 - Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors JF - physica status solidi (a) . 206 (2009), H. 3 Y1 - 2009 SN - 1862-6319 N1 - Special Issue: Engineering of Functional Interfaces (EnFI 08) SP - 462 EP - 467 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Siqueira, Jose R. A1 - Werner, Frederik A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Zucolotto, Valtencir A1 - Oliveira, Osvaldo N. Jr. A1 - Schöning, Michael Josef T1 - Layer-by-Layer Assembly of Carbon Nanotubes Incorporated in Light-Addressable Potentiometric Sensors JF - Journal of Physical Chemistry C. 113 (2009), H. 33 Y1 - 2009 SN - 1932-7455 SP - 14765 EP - 14770 PB - American Chemical Society CY - Washington, DC ER - TY - JOUR A1 - Siqueira, Jose R. A1 - Molinnus, Denise A1 - Beging, Stefan A1 - Schöning, Michael Josef T1 - Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection JF - Analytical chemistry N2 - The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor’s surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance–voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform. Y1 - 2014 U6 - http://dx.doi.org/10.1021/ac500458s SN - 1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print) VL - 86 IS - 11 SP - 5370 EP - 5375 PB - ACS Publications CY - Columbus ER - TY - JOUR A1 - Siqueira, Jose R. A1 - Maki, Rafael M. A1 - Paulovich, Fernando V. A1 - Werner, Frederik A1 - Poghossian, Arshak A1 - Oliveira, Maria C. F. de A1 - Zucolotto, Valtencir A1 - Oliveira, Osvaldo N. Jr. A1 - Schöning, Michael Josef T1 - Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor JF - Analytical Chemistry (2010) Y1 - 2010 SN - 0003-2700 SP - 61 EP - 65 ER - TY - CHAP A1 - Simsek, Beril A1 - Krause, Hans-Joachim A1 - Engelmann, Ulrich M. ED - Digel, Ilya ED - Staat, Manfred ED - Trzewik, Jürgen ED - Sielemann, Stefanie ED - Erni, Daniel ED - Zylka, Waldemar T1 - Magnetic biosensing with magnetic nanoparticles: Simulative approach to predict signal intensity in frequency mixing magnetic detection T2 - 4th YRA MedTech Symposium 2024 : February 1 / 2024 / FH Aachen N2 - Magnetic nanoparticles (MNP) are investigated with great interest for biomedical applications in diagnostics (e.g. imaging: magnetic particle imaging (MPI)), therapeutics (e.g. hyperthermia: magnetic fluid hyperthermia (MFH)) and multi-purpose biosensing (e.g. magnetic immunoassays (MIA)). What all of these applications have in common is that they are based on the unique magnetic relaxation mechanisms of MNP in an alternating magnetic field (AMF). While MFH and MPI are currently the most prominent examples of biomedical applications, here we present results on the relatively new biosensing application of frequency mixing magnetic detection (FMMD) from a simulation perspective. In general, we ask how the key parameters of MNP (core size and magnetic anisotropy) affect the FMMD signal: by varying the core size, we investigate the effect of the magnetic volume per MNP; and by changing the effective magnetic anisotropy, we study the MNPs’ flexibility to leave its preferred magnetization direction. From this, we predict the most effective combination of MNP core size and magnetic anisotropy for maximum signal generation. Y1 - 2024 SN - 978-3-940402-65-3 U6 - http://dx.doi.org/10.17185/duepublico/81475 SP - 27 EP - 28 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Simonis, A. A1 - Ruge, C. A1 - Müller-Veggian, Mattea A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - A long-term stable macroporoustype EIS structure for electrochemical sensor applications JF - Sensors and Actuators B. 91 (2003), H. 1-3 Y1 - 2003 SN - 0925-4005 SP - 21 EP - 25 ER - TY - JOUR A1 - Simonis, A. A1 - Lüth, H. A1 - Wang, J. A1 - Schöning, Michael Josef T1 - New concepts of miniaturised reference electrodes in silicon technology for potentiometric sensor systems JF - Sensors and Actuators B. 103 (2004), H. 1-2 Y1 - 2004 SN - 0925-4005 SP - 429 EP - 435 ER - TY - JOUR A1 - Simonis, A. A1 - Lüth, H. A1 - Wang, J. A1 - Schöning, Michael Josef T1 - Strategies of miniaturised reference electrodes integrated in a silicon-based „one chip“ pH sensor JF - Sensors. 3 (2003), H. 9 Y1 - 2003 SN - 1424-8220 SP - 330 EP - 339 ER - TY - JOUR A1 - Simonis, A. A1 - Krings, T. A1 - Lüth, H. A1 - Wang, J. A1 - Schöning, Michael Josef T1 - A „hybrid“ thin-film pH sensor with integrated thick-film reference JF - Sensors. 1 (2001), H. 6 Y1 - 2001 SN - 1424-8220 SP - 183 EP - 192 ER - TY - JOUR A1 - Simonis, A. A1 - Dawgul, M. A1 - Lüth, H. A1 - Schöning, Michael Josef T1 - Miniaturised reference electrodes for field-effect sensors compatible to silicon chip technology JF - Electrochimica Acta. 51 (2005), H. 5 Y1 - 2005 SN - 0013-4686 U6 - http://dx.doi.org/10.1016/j.electacta.2005.04.063 SP - 930 EP - 937 ER - TY - JOUR A1 - Sildatke, Michael A1 - Karwanni, Hendrik A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - A distributed microservice architecture pattern for the automated generation of information extraction pipelines JF - SN Computer Science N2 - Companies often build their businesses based on product information and therefore try to automate the process of information extraction (IE). Since the information source is usually heterogeneous and non-standardized, classic extract, transform, load techniques reach their limits. Hence, companies must implement the newest findings from research to tackle the challenges of process automation. They require a flexible and robust system that is extendable and ensures the optimal processing of the different document types. This paper provides a distributed microservice architecture pattern that enables the automated generation of IE pipelines. Since their optimal design is individual for each input document, the system ensures the ad-hoc generation of pipelines depending on specific document characteristics at runtime. Furthermore, it introduces the automated quality determination of each available pipeline and controls the integration of new microservices based on their impact on the business value. The introduced system enables fast prototyping of the newest approaches from research and supports companies in automating their IE processes. Based on the automated quality determination, it ensures that the generated pipelines always meet defined business requirements when they come into productive use. KW - Architectural design KW - Model-driven software engineering KW - Software and systems modeling KW - Enterprise information systems KW - Information extraction Y1 - 2023 U6 - http://dx.doi.org/10.1007/s42979-023-02256-4 SN - 2661-8907 N1 - Corresponding authors: Michael Sildatke, Hendrik Karwanni IS - 4, Article number: 833 PB - Springer Singapore CY - Singapore ER - TY - CHAP A1 - Sildatke, Michael A1 - Karwanni, Hendrik A1 - Kraft, Bodo A1 - Schmidts, Oliver A1 - Zündorf, Albert T1 - Automated Software Quality Monitoring in Research Collaboration Projects T2 - ICSEW'20: Proceedings of the IEEE/ACM 42nd International Conference on Software Engineering Workshops Y1 - 2020 U6 - http://dx.doi.org/10.1145/3387940.3391478 SP - 603 EP - 610 ER - TY - JOUR A1 - Siepmann, Thomas A1 - Schuh, G. A1 - Levering, V. T1 - PROPLAN / Schuh, G.; Siepmann, Th.; Levering, V. JF - Handbook on architectures of information systems : with 24 tables / Peter Bernus ... (ed.) Y1 - 1998 SN - 3-540-64453-9 N1 - International handbooks on information systems ; 1 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Siepmann, Thomas A1 - Rupietta, D. T1 - Closer to the customer with computerized product support JF - Technische Mitteilungen Krupp (1993) Y1 - 1993 CY - Essen ER -