TY - JOUR A1 - Grap, Rolf Dietmar T1 - Die Integration von Instandhaltungsaufgaben in die Arbeitsgruppe JF - Gruppenarbeit in der chemischen Industrie / hrsg. vom Bundesarbeitgeberverband Chemie e.V., Wiesbaden Y1 - 1996 SP - 52 EP - 57 PB - Haefner CY - Heidelberg ER - TY - JOUR A1 - Grap, Rolf Dietmar T1 - Re-Integration von Instandhaltungsaufgaben JF - IO-Management / Hrsg.: ETH-Zentrum für Unternehmenswissenschaft BWI. 64 (1995), H. 6 Y1 - 1995 SN - 0019-9281 ; 1422-360 SP - 81 EP - 85 ER - TY - JOUR A1 - Grap, Rolf Dietmar T1 - Informationsmanagement im technischen Büro JF - IO-Management / Hrsg.: ETH-Zentrum für Unternehmenswissenschaft BWI. 59 (1990), H. 10 Y1 - 1990 SN - 0019-9281 ; 1422-360 SP - 17 EP - 21 ER - TY - JOUR A1 - Grap, Rolf Dietmar T1 - Gruppenarbeit: nicht immer das „Ei des Kolumbus“! JF - Personal : Zeitschrift für Human Resource Management. 52 (2000), H. 2 Y1 - 2000 SN - 0031-5605 SP - 90 EP - 94 ER - TY - JOUR A1 - Grap, Rolf Dietmar T1 - Erfassung und Analyse von Arbeitsanforderungen JF - Personal-Management : zukunftsorientierte Personalarbeit / Jürgen Berthel ... (Hrsg.) Y1 - 1990 SN - 3-478-14140-0 N1 - Losebl.-Ausg. Kap. IV, Abschnitt 3.1. PB - Verl. Moderne Industrie CY - Landsberg/Lech ER - TY - JOUR A1 - Grap, Rolf Dietmar T1 - Softwareergonomie bei der Arbeit mit Großrechnern JF - pro Ort (1989) Y1 - 1989 N1 - FIR - Forschungsinstitut für Rationalisierung (Hrsg.); IAW - Institut für Arbeitswissenschaft (Hrsg.) SP - 31 ER - TY - JOUR A1 - Grap, Rolf Dietmar T1 - Computer verstehen lernen : Grafische Simulation rechnerinterner Abläufe als Qualifizierungsmittel JF - Industrie-Anzeiger. 112 (1990), H. 53/54 Y1 - 1990 SN - 0019-9036 N1 - S. 60 f. ER - TY - JOUR A1 - Grap, Rolf Dietmar T1 - Mit Ingenieuren und Betriebswirten gemeinsam zum Industrial Engineer JF - Industrial engineering : Fachzeitschrift des REFA-Bundesverbandes. 62 (2009), H. 2 Y1 - 2009 SN - 1866-2269 SP - 10 EP - 12 ER - TY - JOUR A1 - Grap, Rolf Dietmar T1 - Wrench-time-Studien : Instrumente zur Verbesserung von reaktiven Instandhaltungen bei Großanlagen / von Rolf Grap JF - REFA-Nachrichten : Zeitschrift des REFA-Bundesverbandes e.V., Verband für Arbeitsgestaltung, Betriebsorganisation und Unternehmensentwicklung. 60 (2007), H. 3 Y1 - 2007 SN - 0033-6874 SP - 22 EP - 29 ER - TY - JOUR A1 - Grap, Rolf Dietmar T1 - If you think, education is expensive, try incompetence JF - Beschaffung aktuell (2007) Y1 - 2007 SN - 0341-4507 N1 - freier Zugang nach Registrierung SP - 62 EP - 63 ER - TY - JOUR A1 - Grande, Marion A1 - Meffert, Elisabeth A1 - Schoenberger, Eva A1 - Jung, Stefanie A1 - Frauenrath, Tobias A1 - Huber, Walter A1 - Hussmann, Katja A1 - Moormann, Mareike A1 - Heim, Stefan T1 - From a concept to a word in a syntactically complete sentence: An fMRI study on spontaneous language production in an overt picture description task JF - NeuroImage N2 - Spontaneous language has rarely been subjected to neuroimaging studies. This study therefore introduces a newly developed method for the analysis of linguistic phenomena observed in continuous language production during fMRI. Most neuroimaging studies investigating language have so far focussed on single word or — to a smaller extent — sentence processing, mostly due to methodological considerations. Natural language production, however, is far more than the mere combination of words to larger units. Therefore, the present study aimed at relating brain activation to linguistic phenomena like word-finding difficulties or syntactic completeness in a continuous language fMRI paradigm. A picture description task with special constraints was used to provoke hesitation phenomena and speech errors. The transcribed speech sample was segmented into events of one second and each event was assigned to one category of a complex schema especially developed for this purpose. The main results were: conceptual planning engages bilateral activation of the precuneus. Successful lexical retrieval is accompanied – particularly in comparison to unsolved word-finding difficulties – by the left middle and superior temporal gyrus. Syntactic completeness is reflected in activation of the left inferior frontal gyrus (IFG) (area 44). In sum, the method has proven to be useful for investigating the neural correlates of lexical and syntactic phenomena in an overt picture description task. This opens up new prospects for the analysis of spontaneous language production during fMRI. Y1 - 2012 U6 - https://doi.org/10.1016/j.neuroimage.2012.03.087 SN - 1522-2586 VL - 61 IS - 3 SP - 702 EP - 714 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Köster, Michael A1 - Turek, Stefan T1 - Mathematical and Numerical Analysis of a Robust and Efficient Grid Deformation Method in the Finite Element Context JF - SIAM Journal on Scientific Computing Y1 - 2009 U6 - https://doi.org/10.1137/050639387 VL - 31 IS - 2 SP - 1539 EP - 1557 PB - Society for Industrial and Applied Mathematics CY - Philadelphia, Pa. ER - TY - JOUR A1 - Grajewski, Matthias A1 - Köster, Michael A1 - Turek, Stefam T1 - Numerical analysis and implementational aspects of a new multilevel grid deformation method JF - Applied Numerical Mathematics N2 - Recently, we introduced and mathematically analysed a new method for grid deformation (Grajewski et al., 2009) [15] we call basic deformation method (BDM) here. It generalises the method proposed by Liao et al. (Bochev et al., 1996; Cai et al., 2004; Liao and Anderson, 1992) [4], [6], [20]. In this article, we employ the BDM as core of a new multilevel deformation method (MDM) which leads to vast improvements regarding robustness, accuracy and speed. We achieve this by splitting up the deformation process in a sequence of easier subproblems and by exploiting grid hierarchy. Being of optimal asymptotic complexity, we experience speed-ups up to a factor of 15 in our test cases compared to the BDM. This gives our MDM the potential for tackling large grids and time-dependent problems, where possibly the grid must be dynamically deformed once per time step according to the user's needs. Moreover, we elaborate on implementational aspects, in particular efficient grid searching, which is a key ingredient of the BDM. Y1 - 2010 U6 - https://doi.org/10.1016/j.apnum.2010.03.017 SN - 0168-9274 VL - 60 IS - 8 SP - 767 EP - 781 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Kleefeld, Andreas T1 - Detecting and approximating decision boundaries in low-dimensional spaces JF - Numerical Algorithms N2 - A method for detecting and approximating fault lines or surfaces, respectively, or decision curves in two and three dimensions with guaranteed accuracy is presented. Reformulated as a classification problem, our method starts from a set of scattered points along with the corresponding classification algorithm to construct a representation of a decision curve by points with prescribed maximal distance to the true decision curve. Hereby, our algorithm ensures that the representing point set covers the decision curve in its entire extent and features local refinement based on the geometric properties of the decision curve. We demonstrate applications of our method to problems related to the detection of faults, to multi-criteria decision aid and, in combination with Kirsch’s factorization method, to solving an inverse acoustic scattering problem. In all applications we considered in this work, our method requires significantly less pointwise classifications than previously employed algorithms. KW - MCDA KW - Inverse scattering problem KW - Fault approximation KW - Fault detection Y1 - 2023 SN - 1572-9265 N1 - Corresponding author: Matthias Grajewski VL - 93 IS - 4 PB - Springer Science+Business Media CY - Dordrecht ER - TY - JOUR A1 - Grajewski, Matthias A1 - Hron, Jaroslav A1 - Turek, Stefan T1 - Dual weighted a posteriori error estimation for a new nonconforming linear finite element on quadrilaterals JF - Applied Numerical Mathematics N2 - After a short introduction of a new nonconforming linear finite element on quadrilaterals recently developed by Park, we derive a dual weighted residual-based a posteriori error estimator (in the sense of Becker and Rannacher) for this finite element. By computing a corresponding dual solution we estimate the error with respect to a given target error functional. The reliability and efficiency of this estimator is analyzed in several numerical experiments. Y1 - 2005 U6 - https://doi.org/10.1016/j.apnum.2004.09.016 SN - 0168-9274 VL - 54 IS - 3-4 SP - 504 EP - 518 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Hron, Jaroslav A1 - Turek, Stefan T1 - Numerical analysis for a new non-conforming linear finite element on quadrilaterals JF - Journal of Computational and Applied Mathematics Y1 - 2006 U6 - https://doi.org/10.1016/j.cam.2005.05.024 SN - 0377-0427 VL - 193 IS - 1 SP - 38 EP - 50 ER - TY - JOUR A1 - Goßmann, Matthias A1 - Frotscher, Ralf A1 - Linder, Peter A1 - Bayer, Robin A1 - Epple, U. A1 - Staat, Manfred A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells JF - Cellular physiology and biochemistry N2 - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential. KW - Inotropic compounds KW - Pharmacology KW - Ion channels KW - CellDrum KW - Heart tissue culture KW - Induced pluripotent stem cells KW - Cardiac myocytes Y1 - 2016 U6 - https://doi.org/10.1159/000443124 SN - 1421-9778 (Online) SN - 1015-8987 (Print) VL - 38 IS - 3 SP - 1182 EP - 1198 PB - Karger CY - Basel ER - TY - JOUR A1 - Gossmann, Matthias A1 - Thomas, Ulrich A1 - Horváth, András A1 - Dragicevic, Elena A1 - Stoelzle-Feix, Sonja A1 - Jung, Alexander A1 - Raman, Aravind Hariharan A1 - Staat, Manfred A1 - Linder, Peter T1 - A higher-throughput approach to investigate cardiac contractility in vitro under physiological mechanical conditions JF - Journal of Pharmacological and Toxicological Methods Y1 - 2020 U6 - https://doi.org/10.1016/j.vascn.2020.106843 VL - 105 IS - Article 106843 PB - Elsevier CY - New York, NY ER - TY - JOUR A1 - Gossla, Ulrich A1 - Wanzek, Thorsten T1 - Seßlestalbrücke - Verbundbrücke mit einteiligem Querschnitt / Wanzek, Thorsten; Gossla, Ulrich JF - Aktuelles aus Forschung und Praxis im Umfeld von Mechanik und Statik : Jubiläumsschrift H. Rothert / Hrsg.: Bernd Zastrau ... Technische Universität Dresden, Fakultät Bauingenieurwesen, Inst. für Mechanik und Flächentragwerke Y1 - 2003 SP - 149 EP - 158 PB - Selbstverl. der Techn. Univ. CY - Dresden ER - TY - JOUR A1 - Gossla, Ulrich A1 - Wanzek, T. T1 - Fahrbahnplattentasuch an Verbundbrücken unter laufendem Verkehr / U. Gossla; Th. Wanzek JF - Sicherheit und Wirtschaftlichkeit durch Messtechnik, Monitoring und Beanspruchungsanalyse : Tagung Braunschweig, 12. und 13. Juni 2003 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik Y1 - 2003 SN - 3-18-091757-1 N1 - VDI-Berichte ; 1757; GESA-Symposium 2003 ; (21 : ; 2003.06.12-13 : ; Braunschweig) SP - 467 EP - 472 PB - VDI-Verl. CY - Düsseldorf ER -