TY - RPRT A1 - Damm, Marc André A1 - Anthrakidis, Anette A1 - Fend, Thomas T1 - Keramische Porenkörpersysteme als SCR-Mischer und Hydrolysekatalysator : BMBF-Projekt: Hydromix : Schlussbericht : Laufzeit: 01.10.2011 bis 31.03.2015 Y1 - 2016 CY - Aachen ER - TY - JOUR A1 - Dallas, Shannon A1 - Salphati, Laurent A1 - Gomez-Zepeda, David A1 - Wanek, Thomas A1 - Chen, Liangfu A1 - Chu, Xiaoyan A1 - Kunta, Jeevan A1 - Mezler, Mario A1 - Menet, Marie-Claude A1 - Chasseigneaux, Stephanie A1 - Declèves, Xavier A1 - Langer, Oliver A1 - Pierre, Esaie A1 - DiLoreto, Karen A1 - Hoft, Carolin A1 - Laplanche, Loic A1 - Pang, Jodie A1 - Pereira, Tony A1 - Andonian, Clara A1 - Simic, Damir A1 - Rode, Anja A1 - Yabut, Jocelyn A1 - Zhang, Xiaolin A1 - Scheer, Nico T1 - Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model JF - Molecular Pharmacology N2 - Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp−/−) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP. Y1 - 2016 U6 - http://dx.doi.org/10.1124/mol.115.102079 SN - 1521-0111 VL - 89 IS - 5 SP - 492 EP - 504 PB - ASPET CY - Bethesda, Md. ER - TY - CHAP A1 - Dalguer, Luis A. A1 - Renault, Philippe A1 - Churilov, Sergey A1 - Butenweg, Christoph T1 - Evaluation of fragility curves for a three-storey-reinforced-concrete mock-up of SMART 2013 project T2 - Transactions, SMiRT-23 : 23rd Conference on Structural Mechanics in Reactor Technology : Manchester, United Kingdom - August 10-14, 2015 Y1 - 2016 SP - 1 EP - 9 ER - TY - CHAP A1 - Czarnecki, Christian ED - Mayr, Heinrich C. ED - Pinzger, Martin ED - Gesellschaft für Informatik e. V. (GI), T1 - Design und Nutzung einer industriespezifischen Referenzarchitektur für die Telekommunikationsindustrie T2 - GI Edition Proceedings Band 259 INFORMATIK 2016. 26.-30. September 2016 Klagenfurt N2 - Zur Unterstützung des Transformationsbedarfs von Telekommunikationsunternehmen sind die Referenzmodelle des TM Forums in der Praxis weltweit anerkannt. Dabei findet jedoch meist eine losgelöste Nutzung für spezifische Einzelthemen statt. Daher führt dieser Artikel die bestehenden Inhalte in einer industriespezifischen, übergreifenden Referenzarchitektur zusammen. Der Fokus liegt auf den Ebenen Aufbauorganisation, Prozesse, Applikationen und Daten. Darüber hinaus werden inhaltliche Architekturdomänen zur Strukturierung angeboten. Die Referenzarchitektur ist hierarchisch aufgebaut und wird hier beispielhaft für ausgewählte, aggregierte Inhalte beschrieben. Als erste Evaluation wird die Anwendung der Referenzarchitektur in drei Praxisprojekten erläutert. KW - Referenzmodellierung KW - Unternehmensarchitektur KW - Unternehmenstransformation KW - TM Forum KW - enhanced Telecom Operations Map (eTOM) Y1 - 2016 SN - 9783885796534 SN - 1617-5468 SP - 807 EP - 814 PB - Köllen CY - Bonn ER - TY - JOUR A1 - Chwallek, Constanze A1 - Frohn, Sandra T1 - Den Mitarbeitern den Rücken stärken JF - Personalwirtschaft N2 - Ein Drittel der Mitarbeiter der Saint-Gobain Glass Deutschland GmbH hat drei Jahre lang regelmäßig seinen Rücken trainiert. Mit Erfolg, wie eine abschließende Evaluation in Zusammenarbeit mit der FH Aachen zeigt. Die Fehltage der Trainingsteilnehmer sind enorm zurückgegangen, während die untrainierten Kollegen weiterhin unter Rückenbeschwerden leiden. Y1 - 2016 SN - 0341-4698 IS - 5 SP - 46 EP - 48 PB - F.A.Z. Business Media CY - Frankfurt a.M. ER - TY - JOUR A1 - Chen, Bixia A1 - Schoemberg, Tobias A1 - Kraff, Oliver A1 - Dammann, Philipp A1 - Bitz, Andreas A1 - Schlamann, Marc A1 - Quick, Harald H. A1 - Ladd, Mark E. A1 - Sure, Ulrich A1 - Wrede, Karsten H. T1 - Cranial fixation plates in cerebral magnetic resonance imaging: a 3 and 7 Tesla in vivo image quality study JF - Magnetic Resonance Materials in Physics, Biology and Medicine N2 - Objective This study assesses and quantifies impairment of postoperative magnetic resonance imaging (MRI) at 7 Tesla (T) after implantation of titanium cranial fixation plates (CFPs) for neurosurgical bone flap fixation. Materials and methods The study group comprised five patients who were intra-individually examined with 3 and 7 T MRI preoperatively and postoperatively (within 72 h/3 months) after implantation of CFPs. Acquired sequences included T₁-weighted magnetization-prepared rapid-acquisition gradient-echo (MPRAGE), T₂-weighted turbo-spin-echo (TSE) imaging, and susceptibility-weighted imaging (SWI). Two experienced neurosurgeons and a neuroradiologist rated image quality and the presence of artifacts in consensus reading. Results Minor artifacts occurred around the CFPs in MPRAGE and T2 TSE at both field strengths, with no significant differences between 3 and 7 T. In SWI, artifacts were accentuated in the early postoperative scans at both field strengths due to intracranial air and hemorrhagic remnants. After resorption, the brain tissue directly adjacent to skull bone could still be assessed. Image quality after 3 months was equal to the preoperative examinations at 3 and 7 T. Conclusion Image quality after CFP implantation was not significantly impaired in 7 T MRI, and artifacts were comparable to those in 3 T MRI. Y1 - 2016 U6 - http://dx.doi.org/10.1007/s10334-016-0548-1 SN - 1352-8661 VL - 29 IS - 3 SP - 389 EP - 398 PB - Springer CY - Berlin ER - TY - CHAP A1 - Capitain, C. A1 - Hering, T. A1 - Tippkötter, Nils A1 - Ulber, R. T1 - Enzymatic polymerization of lignin model compounds and solubilized lignin in an aqueous ethanol extract T2 - New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany Y1 - 2016 SP - 151 EP - 152 PB - DECHEMA CY - Frankfurt am Main ER - TY - CHAP A1 - Bäcker, Matthias A1 - Koch, C. A1 - Geiger, F. A1 - Eber, F. A1 - Gliemann, H. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - A New Class of Biosensors Based on Tobacco Mosaic Virus and Coat Proteins as Enzyme Nanocarrier T2 - Procedia Engineering Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.proeng.2016.11.228 SN - 1877-7058 N1 - Proceedings of the 30th anniversary Eurosensors Conference – Eurosensors 2016, 4-7. Sepember 2016, Budapest, Hungary VL - Vol. 168 SP - 618 EP - 621 ER - TY - CHAP A1 - Butenweg, Christoph A1 - Roeser, W. T1 - Auslegung von Bauwerken gegen Erdbeben - Rechenbeispiele T2 - Stahlbetonbau aktuell 2016 : Praxishandbuch / herausgegeben von: Prof. Dr.-Ing. Josef Hegger, Prof. Dr.-Ing. habil. Peter Mark Y1 - 2016 SN - 978-3-410-25202-3 (Print) ; 978-3-410-25203-0 (E-Book) PB - Beuth Verlag GmbH CY - Berlin ; Wien ; Zürich ER - TY - JOUR A1 - Butenweg, Christoph A1 - Marinkovic, Marko A1 - Kubalski, Thomas A1 - Klinkel, Sven T1 - Masonry infilled reinforced concrete frames under horizontal loading T1 - Stahlbetonrahmen mit Ausfachungen aus Mauerwerk unter horizontalen Belastungen JF - Mauerwerk N2 - The behaviour of infilled reinforced concrete frames under horizontal load has been widely investigated, both experimentally and numerically. Since experimental tests represent large investments, numerical simulations offer an efficient approach for a more comprehensive analysis. When RC frames with masonry infill walls are subjected to horizontal loading, their behaviour is highly non-linear after a certain limit, which makes their analysis quite difficult. The non-linear behaviour results from the complex inelastic material properties of the concrete, infill wall and conditions at the wall-frame interface. In order to investigate this non-linear behaviour in detail, a finite element model using a micro modelling approach is developed, which is able to predict the complex non-linear behaviour resulting from the different materials and their interaction. Concrete and bricks are represented by a non-linear material model, while each reinforcement bar is represented as an individual part installed in the concrete part and behaving elasto-plastically. Each brick is modelled individually and connected taking into account the non-linearity of a brick mortar interface. The same approach is followed using two finite element software packages and the results are compared with the experimental results. The numerical models show a good agreement with the experiments in predicting the overall behaviour, but also very good matching for strength capacity and drift. The results emphasize the quality and the valuable contribution of the numerical models for use in parametric studies, which are needed for the derivation of design recommendations for infilled frame structures. Y1 - 2016 U6 - http://dx.doi.org/10.1002/dama.201600703 SN - 1437-1022 VL - 20 IS - 4 SP - 305 EP - 312 PB - Ernst & Sohn CY - Berlin ER - TY - CHAP A1 - Butenweg, Christoph A1 - Kubalski, Thomas A1 - Marinkovic, Marko A1 - Pfetzing, Thomas A1 - Ismail, Mohammed A1 - Fehling, Ekkehard T1 - Ausfachungen aus Ziegelmauerwerk T2 - Mauerwerk-Kalender 2016: Baustoffe, Sanierung, Eurocode-Praxis Y1 - 2016 SN - 978-3-433-03131-5 PB - Ernst & Sohn CY - Berlin ER - TY - CHAP A1 - Bung, Daniel B. A1 - Valero, Daniel ED - Crookston, B. ED - Tullis, B. T1 - Application of the optical flow method to velocity determination in hydraulic structure models BT - Session 11: Fish passage and shiplocks T2 - Hydraulic Structures and Water System Management. 6th IAHR International Symposium on Hydraulic Structures, Portland, OR, 27-30 June 2016 Y1 - 2016 SN - 978-1-884575-75-4 U6 - http://dx.doi.org/10.15142/T3150628160853 SP - 223 EP - 232 ER - TY - CHAP A1 - Bung, Daniel B. A1 - Valero, Daniel ED - Dewals, Benjamin T1 - Image processing techniques for velocity estimation in highly aerated flows: bubble image velocimetry vs. optical flow T2 - Sustainable Hydraulics in the Era of Global Change : Proceedings of the 4th IAHR Europe Congress (Liege, Belgium, 27-29 July 2016) Y1 - 2016 SN - 978-1-138-02977-4 SN - 978-1-4987-8149-7 (eBook) U6 - http://dx.doi.org/10.1201/b21902-31 SP - 151 EP - 157 PB - CRC Press ER - TY - JOUR A1 - Bung, Daniel B. A1 - Valero, Daniel T1 - Optical flow estimation in aerated flows JF - Journal of Hydraulic Research N2 - Optical flow estimation is known from Computer Vision where it is used to determine obstacle movements through a sequence of images following an assumption of brightness conservation. This paper presents the first study on application of the optical flow method to aerated stepped spillway flows. For this purpose, the flow is captured with a high-speed camera and illuminated with a synchronized LED light source. The flow velocities, obtained using a basic Horn–Schunck method for estimation of the optical flow coupled with an image pyramid multi-resolution approach for image filtering, compare well with data from intrusive conductivity probe measurements. Application of the Horn–Schunck method yields densely populated flow field data sets with velocity information for every pixel. It is found that the image pyramid approach has the most significant effect on the accuracy compared to other image processing techniques. However, the final results show some dependency on the pixel intensity distribution, with better accuracy found for grey values between 100 and 150. Y1 - 2016 U6 - http://dx.doi.org/10.1080/00221686.2016.1173600 VL - 54 IS - 5 SP - 575 EP - 580 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Broenner, Simon A1 - Höfken, Hans-Wilhelm A1 - Schuba, Marko T1 - Streamlining extraction and analysis of android RAM images T2 - Proceedings of the 2nd international conference on information systems security and privacy Y1 - 2016 SN - 978-989-758-167-0 U6 - http://dx.doi.org/10.5220/0005652802550264 SP - 255 EP - 264 ER - TY - JOUR A1 - Breuer, Lars A1 - Raue, Markus A1 - Strobel, M. A1 - Mang, Thomas A1 - Schöning, Michael Josef A1 - Thoelen, R. A1 - Wagner, Torsten T1 - Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems JF - Physica status solidi (a) N2 - Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium. Y1 - 2016 U6 - http://dx.doi.org/10.1002/pssa.201533056 SN - 1862-6300 VL - 213 IS - 6 SP - 1520 EP - 1525 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Borchert, Jörg A1 - Rothe, Sebastian ED - Suntrop, Carsten T1 - Energiemanagement und Versorgung von Chemieparks – Ein Ansatz zur wertschöpfungsgetriebenen Risikosteuerung T2 - Chemiestandorte : Markt, Herausforderungen und Geschäftsmodelle Y1 - 2016 SN - 978-3-527-33441-4 SP - 193 EP - 210 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Bonney, Gregor A1 - Nagel, Stefan A1 - Schuba, Marko ED - Schartner, P. T1 - Risiko Smart Home – Angriff auf ein Babymonitorsystem T2 - Proceedings of DACH Security 2016, Klagenfurt, Austria, September 2016 N2 - Unser Zuhause wird zunehmend intelligenter. Smart Homes bieten uns die Steuerung von Haus- oder Unterhaltungstechnik bequem vom Smartphone aus. Junge Familien nutzen die Technologie, um mittels vernetzten Babymonitorsystemen ihren Nachwuchs von überall aus im Blick zu haben. Davon auszugehen, dass solche Systeme mit einem Fokus auf Sicherheit entwickelt wurden, um die sehr persönlichen Daten zu schützen, ist jedoch ein Trugschluss. Die Untersuchung eines handelsüblichen und keineswegs billigen Systems zeigt, dass die Geräte sehr einfach kompromittiert und missbraucht werden können. Y1 - 2016 SP - 371 EP - 378 ER - TY - BOOK A1 - Bleninger, T. A1 - Brenda, M. A1 - Bung, Daniel B. A1 - Hengl, M. A1 - Schmid, B.H. A1 - Schneider, E. A1 - Sonnenburg, A. A1 - Stoschek, O. T1 - DWA-Regelwerk M 544-1 : Merkblatt: Ausbreitungsprobleme von Einleitungen - Prozesse, Methoden und Modelle - Teil 1: Anwendungsgrundlagen, Schätzformeln und eindimensionale Modelle Y1 - 2016 SN - 978-3-88721-280-3 CY - Hennef ER - TY - BOOK A1 - Bleninger, T. A1 - Brenda, M. A1 - Bung, Daniel B. A1 - Hengl, M. A1 - Schmid, B.H. A1 - Schneider, E. A1 - Sonnenburg, A. A1 - Stoschek, O. T1 - DWA-Regelwerk M 544-2 : Merkblatt: Ausbreitungsprobleme von Einleitungen - Prozesse, Methoden und Modelle - Teil 2: Mehrdimensionale Modelle Y1 - 2016 SN - 978-3-88721-281-0 CY - Hennef ER -