TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Probst, M.
A1  - Mai, A.
A1  - Tran, L.
A1  - Vonderstein, K.
A1  - Keschenau, P.
A1  - Linde, T.
A1  - Steinseifer, U.
A1  - Behr, M.
A1  - Mottaghy, K.
T1  - The influence of high shear on thrombosis and hemolysis in artificial organs
JF  - Artificial Organs
Y1  - 2010
SN  - 0391-3988
N1  - Special Issue: SI ; Meeting abstract
VL  - 33
IS  - 7
SP  - 426
EP  - 426
ER  - 
TY  - CHAP
A1  - Duprat, J.
A1  - Dachwald, Bernd
A1  - Hilchenbach, M.
A1  - Engrand, Cecile
A1  - Espe, C.
A1  - Feldmann, M.
A1  - Francke, G.
A1  - Görög, Mark
A1  - Lüsing, N.
A1  - Langenhorst, Falko
T1  - The MARVIN project: a micrometeorite harvester in Antarctic snow
T2  - 44th Lunar and Planetary Science Conference
N2  - MARVIN is an automated drilling and melting probe dedicated to collect pristine interplanetary dust particles (micrometeorites) from central Antarctica snow.
Y1  - 2013
N1  - 44th Lunar and Planetary Science Conference, March 18-22, 2013, The Woodlands, Texas
ER  - 
TY  - CHAP
A1  - Staat, Manfred
A1  - Heitzer, Michael
T1  - The restricted influence of kinematic hardening on shakedown loads
N2  - Structural design analyses are conducted with the aim of verifying the exclusion of ratcheting. To this end it is important to make a clear distinction between the shakedown range and the ratcheting range. In cyclic plasticity more sophisticated hardening models have been suggested in order to model the strain evolution observed in ratcheting experiments. The hardening models used in shakedown analysis are comparatively simple. It is shown that shakedown analysis can make quite stable predictions of admissible load ranges despite the simplicity of the underlying hardening models. A linear and a nonlinear kinematic hardening model of two-surface plasticity are compared in material shakedown analysis. Both give identical or similar shakedown ranges. Structural shakedown analyses show that the loading may have a more pronounced effect than the hardening model.
KW  - Biomedizinische Technik
KW  - Einspielen <Werkstoff>
KW  - Shakedown
KW  - Ratcheting
KW  - Bruchmechanik
KW  - shakedown
KW  - material shakedown
KW  - linear kinematic hardening
KW  - nonlinear kinematic hardening
KW  - ratchetting
Y1  - 2002
ER  - 
TY  - CHAP
A1  - Jean-Pierre P., de Vera
A1  - Baque, Mickael
A1  - Billi, Daniela
A1  - Böttger, Ute
A1  - Bulat, Sergey
A1  - Czupalla, Markus
A1  - Dachwald, Bernd
A1  - de la Torre, Rosa
A1  - Elsaesser, Andreas
A1  - Foucher, Frédéric
A1  - Korsitzky, Hartmut
A1  - Kozyrovska, Natalia
A1  - Läufer, Andreas
A1  - Moeller, Ralf
A1  - Olsson-Francis, Karen
A1  - Onofri, Silvano
A1  - Sommer, Stefan
A1  - Wagner, Dirk
A1  - Westall, Frances
T1  - The search for life on Mars and in the Solar System - strategies, logistics and infrastructures
T2  - 69th International Astronautical Congress (IAC)
N2  - The question "Are we alone in the Universe?" is perhaps the most fundamental one that affects mankind. How can we address the search for life in our Solar System? Mars, Enceladus and Europa are the focus of the search for life outside the terrestrial biosphere. While it is more likely to find remnants of life (fossils of extinct life) on Mars because of its past short time window of the surface habitability, it is probably more likely to find traces of extant life on the icy moons and ocean worlds of Jupiter and Saturn. Nevertheless, even on Mars there could still be a chance to find extant life in niches near to the surface or in just discovered subglacial lakes beneath the South Pole ice cap. Here, the different approaches for the detection of traces of life in the form of biosignatures including pre-biotic molecules will be presented. We will outline the required infrastructure for this enterprise and give examples of future mission concepts to investigate the presence of life on other planets and moons. Finally, we will provide suggestions on methods, techniques, operations and strategies for preparation and realization of future life detection missions.
KW  - life detection
KW  - Mars
KW  - icy moons
KW  - habitability
KW  - space missions
Y1  - 2018
N1  - 69th International Astronautical Congress (IAC), Bremen, Germany, 1-5 October 2018.
SP  - 1
EP  - 8
ER  - 
TY  - CHAP
A1  - Mansurov, Zulkhair
A1  - Zhubanova, Azhar A.
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
A1  - Savitskaja, Irina S.
A1  - Kozhalakova, A. A.
A1  - Kistaubaeva, Aida S.
T1  - The sorption of LPS toxic shock by nanoparticles on base of carbonized vegetable raw materials
N2  - Immobilization of lactobacillus on high temperature carbonizated vegetable raw material (rice husk, grape stones) increases their physiological activity and the quantity of the antibacterial metabolits, that consequently lead to increase of the antagonistic activity of lactobacillus. It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it’s microecology. Besides that, thus, the received carbonizated nanoparticles have peculiar properties – ability to sorption of LPS toxical shock and, hence, to the detoxication of LPS.
KW  - Kohlenstofffaser
KW  - Lipopolysaccharide
KW  - nanostrukturierte carbonisierte Pflanzenteile
KW  - lipopolysaccharides
KW  - nanostructured carbonized plant parts
Y1  - 2008
ER  - 
TY  - JOUR
A1  - Zhubanova, Azhar A.
A1  - Digel, Ilya
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology
N2  - The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.
KW  - Clusterion
KW  - Raumluft
KW  - Luftreiniger
KW  - Plasmacluster ion technology
KW  - Air purification
Y1  - 2007
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Zhubanova, Azhar A.
A1  - Nojima, H.
A1  - Artmann, Gerhard
T1  - The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology
JF  - Biotechnologija : teorija i praktika (2004)
Y1  - 2004
SN  - 1028-9399
SP  - 46
EP  - 52
ER  - 
TY  - CHAP
A1  - Azat, Seitkhan
A1  - Kerimkulova, Almagul R.
A1  - Mansurov, Zulkhair A.
A1  - Adekenov, Sergazy
A1  - Artmann, Gerhard
T1  - The Use of Fusicoccin as Anticancer Compound
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.
Y1  - 2020
SN  - 978-0-429-42864-7
U6  - http://dx.doi.org/10.1201/9780429428647-8
SP  - 149
EP  - 172
PB  - Jenny Stanford Publishing
CY  - New York
ER  - 
TY  - JOUR
A1  - Ciobanu, Octavian
A1  - Staat, Manfred
A1  - Rahimi, Alireza
T1  - The use of open source software in biomechanical finite element analysis
JF  - Buletinul Institutului Politehnic din Iaşi / Universitatea Tehnică Gh. Asachi, Iaşi Secţia 5, Construcţii de maşini = Machine construction = Bulletin of the Polytechnic Institute of Jassy = Izvestija Jasskogo Politechničeskogo Instituta
Y1  - 2008
SN  - 1011-2855
VL  - 54
IS  - 7/8
SP  - 213
EP  - 220
ER  - 
TY  - JOUR
A1  - Stadler, Andreas M.
A1  - Garvey, G. J.
A1  - Bocahut, A.
A1  - Sacquin-Mora, S.
A1  - Digel, Ilya
A1  - Schneider, G. J.
A1  - Natali, F.
A1  - Artmann, Gerhard
A1  - Zaccai, G.
T1  - Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics
JF  - Journal of the Royal Society Interface
N2  - Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 Å at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.
Y1  - 2012
U6  - http://dx.doi.org/10.1098/rsif.2012.0364
SN  - 1742-5689
VL  - 9
IS  - 76
SP  - 2845
EP  - 2855
PB  - The Royal Society
CY  - London
ER  - 
TY  - CHAP
A1  - Frotscher, Ralf
A1  - Staat, Manfred
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.
Y1  - 2018
SN  - 978-981-10-7904-7
U6  - http://dx.doi.org/10.1007/978-981-10-7904-7_10
SP  - 233
EP  - 250
PB  - Springer
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Behr, Marek
A1  - Nicolai, Mike
A1  - Probst, Markus
T1  - Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM
JF  - NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum Jülich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot Münster; Dietrich Wolf; Manfred Kremer (ed.)
Y1  - 2008
SN  - 978-3-9810843-5-1
N1  - NIC series ; 39
SP  - 325
EP  - 332
PB  - Forschungszentrum
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Cronin, Neil J.
A1  - Albracht, Kirsten
A1  - Paulsen, Gøran
A1  - Larsen, Askild V.
A1  - Bojsen-Møller, Jens
A1  - Seynnes, Olivier R.
T1  - Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running
JF  - PeerJ
N2  - Background
During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus.
Methods 
Eleven subjects were assigned to a training group performing isometric singleleg plantarflexion contractions three times per week for ten weeks, and another ten subjects formed a control group. Before and after the training period, Achilles tendon stiffness was estimated, and muscle-tendon mechanics were assessed during running at preferred speed using ultrasonography, kinematics and kinetics.
Results 
Achilles tendon stiffness increased by 18% (P <0:01) in the training group, but the associated reduction in strain seen during isometric contractions was not statistically significant. Tendon elongation during the stance phase of running was similar after training, but tendon recoil was reduced by 30% (P <0:01), while estimated tendon force remained unchanged. Neither gastrocnemius medialis nor soleus fascicle shortening during stance was affected by training.
Discussion 
These results show that a training-induced increase in Achilles tendon
stiffness altered tendon behaviour during running. Despite training-induced changes in tendon mechanical properties and recoil behaviour, the data suggest that fascicle shortening patterns were preserved for the running speed that we examined. The asymmetrical changes in tendon strain patterns supports the notion that simple inseries models do not fully explain the mechanical output of the muscle-tendon unit during a complex task like running.
KW  - Achilles tendon
KW  - Stiffness
KW  - Running
KW  - Tendon properties
KW  - Architectural gear ratio
Y1  - 2019
U6  - http://dx.doi.org/10.7717/peerj.6764
SN  - 21678359
PB  - Peer
CY  - London
ER  - 
TY  - CHAP
A1  - Bayer, Robin
A1  - Hescheler, Jürgen
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
ED  - Staat, Manfred
ED  - Erni, Daniel
T1  - Treating arterial hypertension in a cell culture well
T2  - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW
N2  - Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the “Deutsche Bluthochdruck Liga” this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model.
In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology.
Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching.
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - http://dx.doi.org/10.17185/duepublico/48750
SP  - 5
EP  - 6
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Seynnes, O. R.
A1  - Bojsen-Moller, J.
A1  - Albracht, Kirsten
A1  - Arndt, A.
A1  - Cronin, N. J.
A1  - Finni, T.
A1  - Magnusson, S. P.
T1  - Ultrasound-based testing of tendon mechanical properties: a critical evaluation
JF  - Journal of Applied Physiology
Y1  - 2015
U6  - http://dx.doi.org/10.1152/japplphysiol.00849.2014
SN  - 8750-7587
VL  - 118
IS  - 2
SP  - 133
EP  - 141
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
ED  - Onate, E.
T1  - Uncertain multimode failure and limit analysis of shells
T2  - 11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona
Y1  - 2014
SP  - 1
EP  - 12
ER  - 
TY  - CHAP
A1  - Tran, Thanh Ngoc
A1  - Staat, Manfred
T1  - Uncertainty multimode failure and shakedown analysis of shells
T2  - Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ...
N2  - This paper presents a numerical procedure for reliability analysis of thin plates and shells with respect to plastic collapse or to inadaptation. The procedure involves a deterministic shakedown analysis for each probabilistic iteration, which is based on the upper bound approach and the use of the exact Ilyushin yield surface. Probabilistic shakedown analysis deals with uncertainties originated from the loads, material strength and thickness of the shell. Based on a direct definition of the limit state function, the calculation of the failure probability may be efficiently solved by using the First and Second Order Reliability Methods (FORM and SORM). The problem of reliability of structural systems (series systems) is handled by the application of a special technique which permits to find all the design points corresponding to all the failure modes. Studies show, in this case, that it improves considerably the FORM and SORM results.
KW  - Limit analysis
KW  - Shakedown analysis
KW  - Reliability analysis
KW  - Multimode failure
KW  - Non-linear optimization
Y1  - 2015
SN  - 978-3-319-12927-3 (print) ; 978-3-319-12928-0 (online)
U6  - http://dx.doi.org/10.1007/978-3-319-12928-0_14
SP  - 279
EP  - 298
PB  - Springer
CY  - Cham
ER  - 
TY  - THES
A1  - Pham, Phu Tinh
T1  - Upper bound limit and shakedown analysis of elastic-plastic bounded linearly kinematic hardening structures
Y1  - 2011
N1  - Aachen, Techn. Hochsch., Diss., 2011
PB  - RWTH Aachen University
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Tran, Thanh Ngoc
A1  - Kreißig, R.
A1  - Vu, Duc Khoi
A1  - Staat, Manfred
T1  - Upper bound limit and shakedown analysis of shells using the exact Ilyushin yield surface
JF  - Computer & Structures. 86 (2008)
Y1  - 2008
SN  - 0045-7949
SP  - 1683
EP  - 1695
ER  - 
TY  - JOUR
A1  - Seifarth, Volker
A1  - Schehl, D.
A1  - Linder, Peter
A1  - Gossmann, Matthias
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Porst, Dariusz
A1  - Preiß, C.
A1  - Kayser, Peter
A1  - Pack, O.
A1  - Temiz Artmann, Aysegül
T1  - Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds
N2  - The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.
KW  - Tissue Engineering
KW  - Bioreaktor
KW  - Organkultur
KW  - Harnleiter
Y1  - 2011
ER  -