TY - CHAP A1 - Wollert, Jörg A1 - Rau, S. T1 - Performance von embedded WLAN-Systemen bei koexistierenden Netzwerken T2 - KOMMA 2012 : Kommunikation in der Automation : 3. Jahreskolloquium Kommunikation in der Automation : Lemgo, 14.11.2012 / Jürgen Jasperneite ... (Hrsg.) Y1 - 2012 SN - 978-3-9814062-2-1 PB - Inst. für Industrielle Informationstechnik CY - Lemgo ER - TY - CHAP A1 - Hoffschmidt, Bernhard A1 - Alexopoulos, Spiros T1 - Perspektiven für Solarthermische Kraftwerke im Sonnengürtel T2 - Energiewende : Aspekte, Optionen, Herausforderungen : Vorträge auf der DPG-Frühjahrstagung Arbeitskreis Energie in der Deutschen Physikalischen Gesellschaft Berlin, 26. bis 28. März 2012 / hrsg. von Hardo Bruhns Y1 - 2012 SP - 81 EP - 93 PB - DPG CY - Baf Honnef ER - TY - CHAP A1 - Hüning, Felix ED - Schmitz, Günter T1 - PowerMOSFETs für Elektromotoren im Automobil : Vom Fensterheber zum EPS T2 - Elektronik im Kraftfahrzeug : Innovationen bei Systemen und Komponenten ; mit 7 Tabellen Y1 - 2012 SN - 978-3-8169-3110-2 N1 - Haus der Technik Fachbuchreihe ; 123 SP - 71 EP - 81 PB - Expert Verlag CY - Renningen ER - TY - JOUR A1 - Henken, F. E. A1 - Oosterhuis, K. A1 - Öhlschläger, Peter A1 - Bosch, L. A1 - Hooijberg, E. A1 - Haanen, J. B. A. G. A1 - Steenbergen, R. D. M. T1 - Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7 JF - Vaccine N2 - Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of ‘gene-shuffled’ (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies. Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.vaccine.2012.04.013 SN - 0264-410X VL - 30 IS - 28 SP - 4259 EP - 4266 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Kurz, Melanie T1 - Prizing & Pricing : Design zwischen Rang und Regal T2 - Vielen Dank für Ihren Einkauf : Konsumkultur aus Sicht von Design, Kunst und Medien Y1 - 2012 SN - 978-3-8376-2170-9 U6 - http://dx.doi.org/10.1515/transcript.9783839421703.26 SP - 26 EP - 39 PB - Transcript Verlag CY - Bielefeld ER - TY - CHAP A1 - Klocke, Martina T1 - Projektmodul im Bachelorstudiengang Maschinenbau und Mechatronik T2 - VDI-Workshop Projektorientiertes und problem-basiertes Lernen (PBL) in der Ingenieurausbildung Y1 - 2012 N1 - 25 Folien zum eingeladenen Vortrag beim VDI-Workshop. Darmstadt, 22./23.11.2012 SP - 1 EP - 25 ER - TY - CHAP A1 - Baumann, Torsten A1 - Teixeira Boura, Cristiano José A1 - Eckstein, Julian A1 - Dabrowski, Jan A1 - Göttsche, Joachim A1 - Hoffschmidt, Bernhard A1 - Schmitz, Stefan A1 - Zunft, Stefan T1 - Properties of bulk materials for high-temperature air-sand heat exchangers T2 - 30th ISES Biennial Solar World Congress 2011 : Kassel, Germany, 28 August - 2 September 2011. Vol. 2 Y1 - 2012 SN - 978-1-61839-364-7 SP - 1270 EP - 1278 PB - Curran CY - Red Hook, NY ER - TY - JOUR A1 - Hötter, Jan-Steffen A1 - Fateri, Miranda A1 - Gebhardt, Andreas T1 - Prozessoptimierung des SLM-Prozesses mit hoch-reflektiven und thermisch sehr gut leitenden Materialien durch systematische Parameterfindung und begleitende Simulationen am Beispiel von Silber JF - RTejournal - Forum für Rapid Technologie N2 - Additive Manufacturing durch Aufschmelzen von Metallpulvern hat sich auf breiter Front als Herstellverfahren, auch für Endprodukte, etabliert. Besonders für die Variante des Selective Laser Melting (SLM) sind Anwendungen in der Zahntechnik bereits weit verbreitet und der Einsatz in sensitiven Branchen wie der Luftfahrt ist in greifbare Nähe gerückt. Deshalb werden auch vermehrt Anstrengungen unternommen, um bisher nicht verarbeitete Materialien zu qualifizieren. Dies sind vorzugsweise Nicht-Eisen- und Edelmetalle, die sowohl eine sehr hohe Reflektivität als auch eine sehr gute Wärmeleitfähigkeit aufweisen – beides Eigenschaften, die die Beherrschung des Laser-Schmelzprozesses erschweren und nur kleine Prozessfenster zulassen. Die Arbeitsgruppe SLM des Lehr- und Forschungsgebietes Hochleistungsverfahren der Fertigungstechnik hat sich unter der Randbedingung einer kleinen und mit geringer Laserleistung ausgestatteten SLM Maschine der Aufgabe gewidmet und am Beispiel von Silber die Parameterfelder für Einzelspuren und wenig komplexe Geometrien systematisch untersucht. Die Arbeiten wurden von FEM Simulationen begleitet und durch metallographische Untersuchungen verifiziert. Die Ergebnisse bilden die Grundlage zur schnellen Parameterfindung bei komplexen Geometrien und bei Veränderungen der Zusammensetzung, wie sie bei zukünftigen Legierungen zu erwarten sind. Die Ergebnisse werden exemplarisch auf unterschiedliche Geometrien angewandt und entsprechende Bauteile gezeigt. N2 - Additive manufacturing by melting of metal powders is a method that has been established even for the manufacturing of final products. In particular, Selective Laser Melting (SLM) is currently applied for prosthetic dentistry. In the near future, this technology will access sensitive industries like aerospace engineering. This leads to the need to process new materials. Therefore, especially non-ferrous metals and noble metals must be determined and qualified. These materials have in common a very high reflectivity and an excellent thermal conductivity. In general, these two properties counteract the control of the melt pool and contribute to very narrow process windows. The “SLM” research team of the Aachen University of Applied Science, AcUAS (FH Aachen) systematically investigated process parameter fields for silver. The work focused on a small SLM desktop machine with comparably low laser power. The results are verified using FEA and metallographic inspections and will support future set-ups for complex geometries. Furthermore, the obtained parameter fields are applied to make different geometric objects and to manufactured parts, which are presented. KW - SLM KW - Selektives Laser Schmelzen KW - Silber Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0009-2-33639 SN - 1614-0923 VL - 9 IS - 1 SP - 1 EP - 14 PB - Fachhoschule Aachen CY - Aachen ER - TY - CHAP A1 - Anthrakidis, Anette T1 - Prüfeinrichtung zur Bestimmung der Leistungsfähigkeit von solarthermischen Kollektoren bis 200 Grad C T2 - 22. Symposium Thermische Solarenergie : 09. bis 11. Mai 2012, Kloster Banz, Bad Staffelstein Y1 - 2012 SN - 978-3-941785-89-2 SP - 134 EP - 135 PB - OTTI CY - Regensburg ER - TY - CHAP A1 - Frühwald, Katja A1 - Peterson, Leif Arne A1 - Hasenstab, Andreas ED - Fouad, Nabil A. T1 - Prüfverfahren zur Begutachtung der Materialeigenschaften von Holztragwerken T2 - Bauphysik‐Kalender 2012: Schwerpunkt: Gebäudediagnostik N2 - Dieses Kapitel beinhaltet: - Einleitung - Ausgewählte typische Schäden an Holzbauwerken - Das Material Holz und seine Besonderheiten - Bestandserfassung - Labormethoden - Begutachtungsbeispiele - Zusammenfassung und Schlussfolgerungen - Literatur Y1 - 2012 SN - 9783433029862 (Print) SN - 9783433601235 (Online) U6 - http://dx.doi.org/10.1002/9783433601235.ch4 SP - 103 EP - 155 PB - Ernst & Sohn CY - Berlin ER - TY - THES A1 - Hellmanns, Mark T1 - Qualitätssicherung von handgeführten Applikationsprozessen durch Nachverfolgung der Handhabungseinheit. (Fortschrittsberichte aus der Produktionstechnik ; 1) Y1 - 2012 SN - 978-3-8440-1379-5 N1 - Zugl.: Kassel, Univ., Diss., 2012 PB - Aachen CY - Shaker ER - TY - JOUR A1 - Blecken, Udo A1 - Holthaus-Sellheier, Ursula T1 - Quantitative Prognoseverfahren für Mietpreise von Bueroimmobilien am Beispiel Düsseldorf JF - GuG : Grundstücksmarkt und Grundstückswert Y1 - 2012 SN - 0938-0175 VL - 23 IS - 1 SP - 12 EP - 21 PB - Werner CY - Köln ER - TY - CHAP A1 - Engels, Elmar A1 - Schnabel, Holger T1 - Rapid-control-prototyping of industrial drives for the sercos automation bus T2 - 13th International Workshop on Mechatronics (MECATRONICS), 2012 9th France-Japan & 7th Europe-Asia Congress on and Research and Education in Mechatronics (REM) N2 - This article describes the functionality of a MATLAB® library that can be used to develop motion-logic applications in MATLAB programming language for industrial drive and control systems using the well known sercos automation bus. Therewith MATLAB's functionality is extended to designing automation applications from single axis machines up to multi-kinematic robots. KW - MATLAB , MLPI , Motion control , Open Core , industrial drives , rapid control prototypin , sercos automation bus Y1 - 2012 UR - http://dx.doi.org/10.1109/MECATRONICS.2012.6451005 SN - 978-1-4673-4771-6 SP - 177 EP - 181 ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Friedrich, Peter A1 - Berger, Jörg A1 - Rysstad, Gunnar A1 - Schöning, Michael Josef A1 - Keusgen, Michael T1 - Realisation of a calorimetric gas sensor on polyimide foil for applications in aseptic food industry JF - Sensors and Actuators B: Chemical N2 - A calorimetric gas sensor is presented for the monitoring of vapour-phase H2O2 at elevated temperature during sterilisation processes in aseptic food industry. The sensor was built up on a flexible polyimide foil (thickness: 25 μm) that has been chosen due to its thermal stability and low thermal conductivity. The sensor set-up consists of two temperature-sensitive platinum thin-film resistances passivated by a layer of SU-8 photo resist and catalytically activated by manganese(IV) oxide. Instead of an active heating structure, the calorimetric sensor utilises the elevated temperature of the evaporated H2O2 aerosol. In an experimental test rig, the sensor has shown a sensitivity of 4.78 °C/(%, v/v) in a H2O2 concentration range of 0%, v/v to 8%, v/v. Furthermore, the sensor possesses the same, unchanged sensor signal even at varied medium temperatures between 210 °C and 270 °C of the gas stream. At flow rates of the gas stream from 8 m3/h to 12 m3/h, the sensor has shown only a slightly reduced sensitivity at a low flow rate of 8 m3/h. The sensor characterisation demonstrates the suitability of the calorimetric gas sensor for monitoring the efficiency of industrial sterilisation processes. KW - Sterilisation process KW - Hydrogen peroxide KW - Polyimide KW - Calorimetric gas sensor Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.snb.2011.01.032 SN - 0925-4005 N1 - Part of special issue "Eurosensors XXIV, 2010" VL - 170 SP - 60 EP - 66 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Leidinger, Rafael A1 - Noisten, Thomas A1 - Wollert, Jörg T1 - Realtime automation networks in moVing industrial environments JF - Journal of systemics, cybernetics and informatics N2 - The radio-based wireless data communication has made the realization of new technical solutions possible in many fields of the automation technology (AT). For about ten years, a constant disproportionate growth of wireless technologies can be observed in the automation technology. However, it shows that especially for the AT, conventional technologies of office automation are unsuitable and/or not manageable. The employment of mobile services in the industrial automation technology has the potential of significant cost and time savings. This leads to an increased productivity in various fields of the AT, for example in the factory and process automation or in production logistics. In this paper technologies and solutions for an automation-suited supply of mobile wireless services will be introduced under the criteria of real time suitability, IT-security and service orientation. Emphasis will be put on the investigation and development of wireless convergence layers for different radio technologies, on the central provision of support services for an easy-to-use, central, backup enabled management of combined wired / wireless networks and on the study on integrability in a Profinet real-time Ethernet network. KW - PROFINET KW - Distributed Control Systems, KW - Industrial Automation Technology, KW - 802.15.4 KW - Bluetooth KW - Wireless Networks Y1 - 2012 SN - 1690-4532 VL - Vol. 10 IS - Iss. 2 SP - 52 EP - 56 PB - IIIC CY - Orlando ER - TY - JOUR A1 - Lind, Thorsten Patric T1 - Rechtsprobleme bei der Liquidation der GmbH und der Gewinnausschüttung trotz bestehenden Anspruchs gegen den Gesellschafter : BGH, Urteil vom 23.04.2012 - II ZR 252/10 : Anmerkung JF - Fachdienst Zivilrecht - LMK - Kommentierte BGH-Rechtsprechung, Lindenmaier-Möhring Y1 - 2012 SN - 1611-1095 IS - Ausg. 10 SP - 338415 PB - Beck CY - München ER - TY - JOUR A1 - Herzwurm, Georg A1 - Krams, Benedikt A1 - Pietsch, Wolfram A1 - Schockert, Sixten T1 - Report from the 3rd international workshop on requirements prioritization for customer oriented software development (RePriCo’12) JF - ACM SIGSOFT Software Engineering Notes N2 - Prioritization is an essential task within requirements engineering to cope with complexity and to establish focus properly. The 3rd Workshop on Requirements Prioritization for customer oriented Software Development (RePriCo’12) focused on requirements prioritization and adjacent themes in the context of customer oriented development of bespoke and standard software. Five submissions have been accepted for the proceedings and for presentation. The report summarizes and points out key findings. KW - Requirements relations KW - Discourse ethics KW - Tool support KW - Consensus KW - Requirements prioritization Y1 - 2012 U6 - http://dx.doi.org/10.1145/2237796.2237817 SN - 0163-5948 VL - 37 IS - 4 SP - 32 EP - 34 PB - Association for Computing Machinery CY - New York ER - TY - JOUR A1 - Kurulgan Demirci, Eylem A1 - Demirci, Taylan A1 - Linder, Peter A1 - Trzewik, Jürgen A1 - Gierkowski, Jessica Ricarda A1 - Gossmann, Matthias A1 - Kayser, Peter A1 - Porst, Dariusz A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells JF - Journal of Bioscience and Bioengineering N2 - All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models. KW - Cell permeability KW - Cellular force KW - Endothelial cells KW - Recombinant activated protein C KW - Lipopolysaccharide KW - Contractile tension KW - CellDrum Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.jbiosc.2012.03.019 SN - 1347-4421 VL - 113 IS - 2 SP - 212 EP - 219 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Thomas, Axel T1 - Rhetorische Knallfrösche - reloaded : Zitatensammlung für Politik und Wirtschaft Y1 - 2012 PB - Neck + Heyn CY - Aachen ER - TY - CHAP A1 - Borchert, Jörg A1 - Lintzel, P. ED - Zenke, Ines T1 - Risiken des Handels T2 - Energiehandel in Europa Y1 - 2012 SN - 978-3-9813142-9-8 SP - 303 EP - 312 PB - Beck CY - München ET - 3. Aufl. ER -