TY - CHAP A1 - Ketelhut, Maike A1 - Göll, Fabian A1 - Braunstein, Bjoern A1 - Albracht, Kirsten A1 - Abel, Dirk T1 - Iterative learning control of an industrial robot for neuromuscular training T2 - 2019 IEEE Conference on Control Technology and Applications N2 - Effective training requires high muscle forces potentially leading to training-induced injuries. Thus, continuous monitoring and controlling of the loadings applied to the musculoskeletal system along the motion trajectory is required. In this paper, a norm-optimal iterative learning control algorithm for the robot-assisted training is developed. The algorithm aims at minimizing the external knee joint moment, which is commonly used to quantify the loading of the medial compartment. To estimate the external knee joint moment, a musculoskeletal lower extremity model is implemented in OpenSim and coupled with a model of an industrial robot and a force plate mounted at its end-effector. The algorithm is tested in simulation for patients with varus, normal and valgus alignment of the knee. The results show that the algorithm is able to minimize the external knee joint moment in all three cases and converges after less than seven iterations. KW - Knee KW - Training KW - Load modeling KW - Force KW - Iterative learning control Y1 - 2019 SN - 978-1-7281-2767-5 (ePub) SN - 978-1-7281-2766-8 (USB) SN - 978-1-7281-2768-2 (PoD) U6 - https://doi.org/10.1109/CCTA.2019.8920659 N1 - 2019 IEEE Conference on Control Technology and Applications (CCTA) Hong Kong, China, August 19-21, 2019 PB - IEEE CY - New York ER - TY - JOUR A1 - Meyer, Carolin A1 - Gaalen, Kerstin van A1 - Leschinger, Tim A1 - Scheyerer, Max J. A1 - Neiss, Wolfram F. A1 - Staat, Manfred A1 - Müller, Lars P. A1 - Wegmann, Kilian T1 - Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement JF - BioMed Research International Y1 - 2019 U6 - https://doi.org/10.1155/2019/9232813 SP - Article ID 9232813 ER - TY - THES A1 - Tran, Ngoc Trinh T1 - Limit and Shakedown analysis of structures under stochastic conditions Y1 - 2019 U6 - https://doi.org/10.24355/dbbs.084-201902121135-0 PB - Technische Universität Braunschweig CY - Braunschweig ER - TY - JOUR A1 - Roeth, A.A. A1 - Slabu, I. A1 - Kessler, A. A1 - Engelmann, Ulrich M. T1 - Local treatment of pancreatic cancer with magnetic nanoparticles JF - HPB Y1 - 2019 U6 - https://doi.org/10.1016/j.hpb.2019.10.959 SN - 1365-182X VL - 21 IS - Supplement 3 SP - S868 EP - S869 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Tippkötter, Nils A1 - Möhring, Sophie A1 - Roth, Jasmine A1 - Wulfhorst, Helene T1 - Logistics of lignocellulosic feedstocks: preprocessing as a preferable option T2 - Biorefineries N2 - In comparison to crude oil, biorefinery raw materials are challenging in concerns of transport and storage. The plant raw materials are more voluminous, so that shredding and compacting usually are necessary before transport. These mechanical processes can have a negative influence on the subsequent biotechnological processing and shelf life of the raw materials. Various approaches and their effects on renewable raw materials are shown. In addition, aspects of decentralized pretreatment steps are discussed. Another important aspect of pretreatment is the varying composition of the raw materials depending on the growth conditions. This problem can be solved with advanced on-site spectrometric analysis of the material. KW - Analytics KW - Decentral KW - Mechanical KW - On-site KW - Pre-treatment Y1 - 2019 SN - 978-3-319-97117-9 SN - 978-3-319-97119-3 U6 - https://doi.org/10.1007/10_2017_58 N1 - Advances in biochemical engineering/biotechnology ; Vol. 166 SP - 43 EP - 68 PB - Springer CY - Cham ER - TY - CHAP A1 - Stenger, David A1 - Altherr, Lena A1 - Abel, Dirk T1 - Machine learning and metaheuristics for black-box optimization of product families: a case-study investigating solution quality vs. computational overhead T2 - Operations Research Proceedings 2018 N2 - In product development, numerous design decisions have to be made. Multi-domain virtual prototyping provides a variety of tools to assess technical feasibility of design options, however often requires substantial computational effort for just a single evaluation. A special challenge is therefore the optimal design of product families, which consist of a group of products derived from a common platform. Finding an optimal platform configuration (stating what is shared and what is individually designed for each product) and an optimal design of all products simultaneously leads to a mixed-integer nonlinear black-box optimization model. We present an optimization approach based on metamodels and a metaheuristic. To increase computational efficiency and solution quality, we compare different types of Gaussian process regression metamodels adapted from the domain of machine learning, and combine them with a genetic algorithm. We illustrate our approach on the example of a product family of electrical drives, and investigate the trade-off between solution quality and computational overhead. KW - Product family optimization KW - Mixed-integer nonlinear black-box optimization KW - Engineering optimization KW - Machine learning Y1 - 2019 SN - 978-3-030-18499-5 (Print) SN - 978-3-030-18500-8 (Online) U6 - https://doi.org/10.1007/978-3-030-18500-8_47 SP - 379 EP - 385 PB - Springer CY - Cham ER - TY - CHAP A1 - Hailer, Benjamin A1 - Weber, Tobias A1 - Arent, Jan-Christoph T1 - Manufacturing Process Simulation for Autoclave-Produced Sandwich Structures T2 - Proceedings of SAMPE Europe Conference 2019, Nantes, France Y1 - 2019 SP - 1 EP - 8 ER - TY - CHAP A1 - Weber, Tobias A1 - Englhard, Markus A1 - Hailer, Benjamin A1 - Arent, Jan-Christoph T1 - Manufacturing Process Simulation for the Prediction of Tool-Part-Interaction and Ply Wrinkling T2 - Proceedings of SAMPE Europe Conference 2019, Nantes, France Y1 - 2019 SP - 1 EP - 10 ER - TY - CHAP A1 - Finger, Felix A1 - Götten, Falk A1 - Braun, Carsten A1 - Bil, Cees T1 - Mass, Primary Energy, and Cost - The Impact of Optimization Objectives on the Initial Sizing of Hybrid-Electric General Aviation Aircraft T2 - Deutscher Luft- und Raumfahrtkongress 2019, DLRK 2019. Darmstadt, Germany Y1 - 2019 U6 - https://doi.org/10.25967/490012 SP - 1 EP - 17 ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Schönenborn, Kristina A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim T1 - Measurement of the magnetophoretic velocity of different superparamagnetic beads JF - Journal of Magnetism and Magnetic Materials N2 - The movement of magnetic beads due to a magnetic field gradient is of great interest in different application fields. In this report we present a technique based on a magnetic tweezers setup to measure the velocity factor of magnetically actuated individual superparamagnetic beads in a fluidic environment. Several beads can be tracked simultaneously in order to gain and improve statistics. Furthermore we show our results for different beads with hydrodynamic diameters between 200 and 1000 nm from diverse manufacturers. These measurement data can, for example, be used to determine design parameters for a magnetic separation system, like maximum flow rate and minimum separation time, or to select suitable beads for fixed experimental requirements. KW - magnetophoretic velocity KW - superparamagnetic bead KW - magnetic tweezers KW - magnetic separation KW - magnetic actuation Y1 - 2019 U6 - https://doi.org/10.1016/j.jmmm.2018.10.066 SN - 0304-8853 VL - 477 IS - 1 SP - 244 EP - 248 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Scholl, Ingrid A1 - Bartella, Alex A1 - Moluluo, Cem A1 - Ertural, Berat A1 - Laing, Frederic A1 - Suder, Sebastian T1 - MedicVR : Acceleration and Enhancement Techniques for Direct Volume Rendering in Virtual Reality T2 - Bildverarbeitung für die Medizin 2019 : Algorithmen – Systeme – Anwendungen Y1 - 2019 SN - 978-3-658-25326-4 U6 - https://doi.org/10.1007/978-3-658-25326-4_32 SP - 152 EP - 157 PB - Springer Vieweg CY - Wiesbaden ER - TY - JOUR A1 - Schildt, Ph. A1 - Braun, Carsten A1 - Marzocca, P. T1 - Metric evaluating potentials of condition-monitoring approaches for hybrid electric aircraft propulsion systems JF - CEAS Aeronautical Journal Y1 - 2019 U6 - https://doi.org/10.1007/s13272-019-00411-3 SN - 1869-5590 SP - 1 EP - 14 PB - Springer CY - Berlin ER - TY - JOUR A1 - Campen, R. A1 - Kowalski, Julia A1 - Lyons, W.B. A1 - Tulaczyk, S. A1 - Dachwald, Bernd A1 - Pettit, E. A1 - Welch, K. A. A1 - Mikucki, J.A. T1 - Microbial diversity of an Antarctic subglacial community and high‐resolution replicate sampling inform hydrological connectivity in a polar desert JF - Environmental Microbiology Y1 - 2019 U6 - https://doi.org/10.1111/1462-2920.14607 SN - 1462-2920 IS - accepted article PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Braun, Sebastian A1 - Cheng, Chi-Tsun A1 - Lai, Chow Yin A1 - Wollert, Jörg T1 - Microservice Architecture for Automation - Realization by the example of a model-factory’s manufacturing execution system T2 - Proceedings of the 23rd World Multi-Conference on Systemics, Cybernetics and Informatics: WMSCI 2019 Y1 - 2019 SP - 33 EP - 37 ER - TY - JOUR A1 - Jung, Alexander A1 - Staat, Manfred T1 - Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue JF - GAMM - Mitteilungen der Gesellschaft für Angewandte Mathematik und Mechanik Y1 - 2019 U6 - https://doi.org/10.1002/gamm.201900002 SN - 1522-2608 VL - 42 IS - 4 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Slabu, Ioana A1 - Roeth, Anjali A. A1 - Engelmann, Ulrich M. A1 - Wiekhorst, Frank A1 - Buhl, Eva M. A1 - Neumann, Ulf P. A1 - Schmitz-Rode, Thomas T1 - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro JF - Nanotechnology Y1 - 2019 U6 - https://doi.org/10.1088/1361-6528/ab033e SN - 1361-6528 VL - 30 IS - 18 SP - 184004 ER - TY - CHAP A1 - Raman, Aravind Hariharan A1 - Jung, Alexander A1 - Horváth, András A1 - Becker, Nadine A1 - Staat, Manfred ED - Staat, Manfred ED - Erni, Daniel T1 - Modification of a computer model of human stem cell-derived cardiomyocyte electrophysiology based on Patch-Clamp measurements T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen N2 - Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich). Y1 - 2019 SN - 978-3-940402-22-6 U6 - https://doi.org/10.17185/duepublico/48750 SP - 10 EP - 11 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - JOUR A1 - Albanna, Walid A1 - Lüke, Jan Niklas A1 - Schubert, Gerrit Alexander A1 - Dibué-Adjei, Maxine A1 - Kotliar, Konstantin A1 - Hescheler, Jürgen A1 - Clusmann, Hans A1 - Steiger, Hans-Jakob A1 - Hänggi, Daniel A1 - Kamp, Marcel A. A1 - Schneider, Toni A1 - Neumaier, Felix T1 - Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity JF - Molecular and Cellular Neuroscience Y1 - 2019 U6 - https://doi.org/10.1016/j.mcn.2019.03.003 SN - 1044-7431 VL - 96 IS - 4 SP - 35 EP - 46 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Müller, Tim M. A1 - Altherr, Lena A1 - Ahola, Marja A1 - Schabel, Samuel A1 - Pelz, Peter F. ED - Rodrigues, H. C. T1 - Multi-Criteria optimization of pressure screen systems in paper recycling – balancing quality, yield, energy consumption and system complexity T2 - EngOpt 2018 Proceedings of the 6th International Conference on Engineering Optimization N2 - The paper industry is the industry with the third highest energy consumption in the European Union. Using recycled paper instead of fresh fibers for papermaking is less energy consuming and saves resources. However, adhesive contaminants in recycled paper are particularly problematic since they reduce the quality of the resulting paper-product. To remove as many contaminants and at the same time obtain as many valuable fibres as possible, fine screening systems, consisting of multiple interconnected pressure screens, are used. Choosing the best configuration is a non-trivial task: The screens can be interconnected in several ways, and suitable screen designs as well as operational parameters have to be selected. Additionally, one has to face conflicting objectives. In this paper, we present an approach for the multi-criteria optimization of pressure screen systems based on Mixed-Integer Nonlinear Programming. We specifically focus on a clear representation of the trade-off between different objectives. Y1 - 2019 SN - 978-3-319-97773-7 U6 - https://doi.org/10.1007/978-3-319-97773-7_105 N1 - EngOpt 2018 Proceedings of the 6th International Conference on Engineering Optimization. 17-19 September 2018. Lisboa, Portugal PB - Springer International Publishing CY - Basel ER - TY - JOUR A1 - Göttsche, Joachim A1 - Alexopoulos, Spiros A1 - Dümmler, Andreas A1 - Maddineni, S. K. T1 - Multi-Mirror Array Calculations With Optical Error N2 - The optical performance of a 2-axis solar concentrator was simulated with the COMSOL Multiphysics® software. The concentrator consists of a mirror array, which was created using the application builder. The mirror facets are preconfigured to form a focal point. During tracking all mirrors are moved simultaneously in a coupled mode by 2 motors in two axes, in order to keep the system in focus with the moving sun. Optical errors on each reflecting surface were implemented in combination with the solar angular cone of ± 4.65 mrad. As a result, the intercept factor of solar radiation that is available to the receiver was calculated as a function of the transversal and longitudinal angles of incidence. In addition, the intensity distribution on the receiver plane was calculated as a function of the incidence angles. KW - solar process heat KW - concentrating collector KW - raytracing KW - point-focussing system Y1 - 2019 SP - 1 EP - 6 ER -