TY  - JOUR
A1  - Heuermann, Holger
A1  - Sadeghfam, Arash
T1  - Novel balanced inductor for compact differential systems / Sadeghfam, Arash; Heuermann, Holger
JF  - Conference proceedings : Tuesday 12th, Wednesday 13th and Thursday 14th October, [RAI International Exhibition and Congress Centre, Amsterdam ; part of European Microwave Week 2004] / EuMA, European Microwave Association
Y1  - 2004
SN  - 1-580-53992-0
N1  - European Microwave Conference ; (34, 2004, Amsterdam) ; European Microwave Week ; (7, 2004, Amsterdam)
SP  - 709
EP  - 712
PB  - Horizon House Publ.
CY  - London
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Jelinek, N.
A1  - Schmidt, S.
A1  - Hilbert, U.
T1  - Novel bioreactors for the ex vivo cultivation of hematopoietic cells / Jelinek, N. ; Schmidt, S. ; Hilbert, U. ; Thoma, S. ; Biselli, M. ; Wandrey, C.
JF  - Engineering in Life Sciences. 2 (2002), H. 1
Y1  - 2002
SN  - 1618-0240
SP  - 15
EP  - 18
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Miyamoto, Ko-ichiro
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging
JF  - Procedia Engineering. 5 (2010)
Y1  - 2010
SN  - 1877-7058
N1  - Eurosensor XXIV Conference
SP  - 520
EP  - 523
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
A1  - Hillebrand, Jürgen
A1  - Sadeghfam, Arash
T1  - Novel Concept of a Digital SigmaDelta-PLL-Phase-Shift-Modulator / Hillebrand, Jürgen ; Sadeghfam, Arash ; Heuermann, Holger
Y1  - 2008
SN  - 978-3-8007-3086-5
N1  - Microwave Conference (GeMIC), 2008 German
SP  - 123
EP  - 126
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Berndsen, Lars
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Novel concepts for flow-rate and flow-direction determination by means of pH-sensitive ISFETs
JF  - Proceedings of SPIE. 4560 (2001)
Y1  - 2001
SP  - 19
EP  - 27
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Lüth, H.
T1  - Novel concepts for silicon-based biosensors
JF  - Physica Status Solidi (A) (2001)
Y1  - 2001
SN  - 0031-8965
SP  - 65
EP  - 77
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Malkoc, Ü.
A1  - Thust, M.
A1  - Steffen, A.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Novel electrochemical sensors with structured and porous semiconductor/insulator capacitors
JF  - Sensors and Actuators B. 65 (2000), H. 1-3
Y1  - 2000
SN  - 0925-4005
SP  - 288
EP  - 290
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Malkoc, Ü.
A1  - Thust, M.
A1  - Steffen, A.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Novel electrochemical sensors with structured and porous semiconductor/insulator capacitors
JF  - Proceedings of the Seventh International Meeting on Chemical Sensors : 27 - 30 July, 1998, Beijing, P. R. China / ed. Zhi-Gang Zhou
Y1  - 1998
N1  - International Meeting on Chemical Sensors ; (7, 1998, Beijing) ; International Meeting on Chemical Sensors (IMCS) ; (7 : ; 1998.07.27-30 : ; Beijing)
SP  - 885
EP  - 887
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Jennemann, Richard
A1  - Bauer, Bernhard L.
A1  - Bertalanffy, Helmut
T1  - Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus / Jennemann, Richard ; Bauer, Bernhard, L. ; Bertalanffy, Helmut ; Geyer, Rudolf ; Gschwind, Ruth, M. ; Selmer, Thorsten ; Wiegandt, Herbert
JF  - European Journal of Biochemistry. 259 (1999), H. 1-2
Y1  - 1999
SN  - 0014-2956
SP  - 331
EP  - 338
ER  - 
TY  - JOUR
A1  - Förster, Arnold
A1  - Lachenmann, S. G.
A1  - Kastalsky, A.
T1  - Novel hybrid Nb/InAs/Nb step junctions / S. G. Lachenmann ; A. Kastalsky ; I. Friedrich ; A. Förster ...
JF  - Czechoslovak journal of physics . 46 (1996), H. S2
Y1  - 1996
SN  - 0011-4626
SP  - 659
ER  - 
TY  - JOUR
A1  - Guo, Yuanyuan
A1  - Seki, Kosuke
A1  - Miyamoto, Ko-ichiro
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution
JF  - Applied physics express : APEX
N2  - A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) is proposed to achieve a higher spatial resolution of chemical images. The proposed method employs a combined light source that consists of a modulated light probe, which generates the alternating photocurrent signal, and a ring of constant illumination surrounding it. The constant illumination generates a sheath of carriers with increased concentration which suppresses the spread of photocarriers by enhanced recombination. A device simulation was carried out to verify the effect of constant illumination on the spatial resolution, which demonstrated that a higher spatial resolution can be obtained.
Y1  - 2014
U6  - https://doi.org/10.7567/APEX.7.067301
SN  - 1882-0786 (E-Journa); 1882-0778 (Print)
VL  - 7
IS  - 6
SP  - 067301-4
PB  - IOP
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Seiler, Friedrich
A1  - Pichler, Alexander
A1  - Pfaff, Raphael
A1  - Srulijes, Julio
T1  - Novel processing tools for automated doppler picture velocimetry (DPV) evaluation
JF  - Journal of visualization
Y1  - 2009
SN  - 1343-8875
VL  - Vol. 12
IS  - Iss. 4
SP  - 323
EP  - 337
ER  - 
TY  - JOUR
A1  - Haeger, Gerrit
A1  - Jolmes, Tristan
A1  - Oyen, Sven
A1  - Jaeger, Karl-Erich
A1  - Bongaerts, Johannes
A1  - Schörken, Ulrich
A1  - Siegert, Petra
T1  - Novel recombinant aminoacylase from Paraburkholderia monticola capable of N-acyl-amino acid synthesis
JF  - Applied Microbiology and Biotechnology
N2  - N-Acyl-amino acids can act as mild biobased surfactants, which are used, e.g., in baby shampoos. However, their chemical synthesis needs acyl chlorides and does not meet sustainability criteria. Thus, the identification of biocatalysts to develop greener synthesis routes is desirable. We describe a novel aminoacylase from Paraburkholderia monticola DSM 100849 (PmAcy) which was identified, cloned, and evaluated for its N-acyl-amino acid synthesis potential. Soluble protein was obtained by expression in lactose autoinduction medium and co-expression of molecular chaperones GroEL/S. Strep-tag affinity purification enriched the enzyme 16-fold and yielded 15 mg pure enzyme from 100 mL of culture. Biochemical characterization revealed that PmAcy possesses beneficial traits for industrial application like high temperature and pH-stability. A heat activation of PmAcy was observed upon incubation at temperatures up to 80 °C. Hydrolytic activity of PmAcy was detected with several N-acyl-amino acids as substrates and exhibited the highest conversion rate of 773 U/mg with N-lauroyl-L-alanine at 75 °C. The enzyme preferred long-chain acyl-amino-acids and displayed hardly any activity with acetyl-amino acids. PmAcy was also capable of N-acyl-amino acid synthesis with good conversion rates. The best synthesis results were obtained with the cationic L-amino acids L-arginine and L-lysine as well as with L-leucine and L-phenylalanine. Exemplarily, L-phenylalanine was acylated with fatty acids of chain lengths from C8 to C18 with conversion rates of up to 75%. N-lauroyl-L-phenylalanine was purified by precipitation, and the structure of the reaction product was verified by LC–MS and NMR.
KW  - Chaperone
KW  - Biocatalysis
KW  - Aminoacylase
KW  - Acylation
KW  - Acyl-amino acids
KW  - Biosurfactants
Y1  - 2024
U6  - https://doi.org/10.1007/s00253-023-12868-8
SN  - 1432-0614
N1  - Corresponding author: Petra Siegert
IS  - 108
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
A1  - Erkens, H.
T1  - Novel RF switch concepts for differential wireless communications frontends. Erkens, H.; Heuermann, H.
JF  - IEEE Transactions on Microwave Theory and Techniques. 54 (2006), H. 6, Part 1
Y1  - 2006
SN  - 0018-9480
SP  - 2376
EP  - 2382
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
A1  - Ibrahim, Irfan
T1  - Novel theory and architecture of a vector signal generator implemented with two PLLs / Ibrahim, Irfan ; Heuermann, Holger
JF  - European Conference on Wireless Technology, 2008. EuWiT 2008.
Y1  - 2008
SN  - 978-2-87487-008-8
SP  - 85
EP  - 88
ER  - 
TY  - JOUR
A1  - Iken, Heiko
A1  - Kirsanov, D.
A1  - Legin, A.
A1  - Schöning, Michael Josef
T1  - Novel Thin-Film Polymeric Materials for the Detection of Heavy Metals
JF  - Procedia Engineering
N2  - A variety of transition metals, e.g., copper, zinc, cadmium, lead, etc. are widely used in industry as components for wires, coatings, alloys, batteries, paints and so on. The inevitable presence of transition metals in industrial processes implies the ambition of developing a proper analytical technique for their adequate monitoring. Most of these elements, especially lead and cadmium, are acutely toxic for biological organisms. Quantitative determination of these metals at low activity levels in different environmental and industrial samples is therefore a vital task. A promising approach to achieve an at-side or on-line monitoring on a miniaturized and cost efficient way is the combination of a common potentiometric sensor array with heavy metal-sensitive thin-film materials, like chalcogenide glasses and polymeric materials, respectively.
Y1  - 2012
U6  - https://doi.org/10.1016/j.proeng.2012.09.148
SN  - 1877-7058
N1  - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012"
IS  - 47
SP  - 322
EP  - 325
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
A1  - Thalayasingam, K.
T1  - Novel vector non-linear measurement system for intermodulation measurements  / Thalayasingam, K.; Heuermann, H.
JF  - European Microwave Conference, 2009 : EuMC 2009 ; Sept. 29, 2009 - Oct. 1, 2009, Rome, Italy ; part of European Microwave Week (EuMW) / sponsored by EuMA, European Microwave Association ... Endorsed by IEEE
Y1  - 2009
SN  - 978-1-4244-4748-0
N1  - European Microwave Conference ; (39 : ; 2009.09.29-10.01 : ; Rome)
SP  - 926
EP  - 929
PB  - IEEE
CY  - Piscataway, NJ
ER  - 
TY  - JOUR
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W.K.
T1  - Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material
JF  - Journal of Pharmaceutical and Biomedical Analysis
N2  - Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed. For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard. The method was successfully validated for its accuracy, reproducibility, and precision. The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w % and 64.4 w/w %. The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride. A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available. A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs. NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).
KW  - NMR spectroscopy
KW  - Heparin
KW  - Crude heparin
KW  - USP
KW  - Ions
Y1  - 2022
U6  - https://doi.org/10.1016/j.jpba.2022.114915
SN  - 0731-7085
VL  - 219
IS  - Article number: 114915
PB  - Elsevier
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Stanley, Lesley A.
A1  - Horsburgh, Brian C.
A1  - Ross, Jillian
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Nuclear Receptors which play a pivotal role in drug disposition and chemical toxicity
JF  - Drug Metabolism Reviews
Y1  - 2006
U6  - https://doi.org/10.1080/03602530600786232
SN  - 1097-9883
VL  - 38
IS  - 3
SP  - 515
EP  - 597
ER  - 
TY  - JOUR
A1  - Hoyler, Friedrich
A1  - Hoff, R. W.
A1  - Börner, H. G.
T1  - Nuclear structure of 170Tm from neutron-capture and (d,p)-reaction measurements / R. W. Hoff ; H. G. Börner ... F. Hoyler ...
JF  - Physical review / C. 54 (1996), H. 1
Y1  - 1996
SN  - 0556-2813
SP  - 78
EP  - 116
ER  -