TY  - JOUR
A1  - Karschuck, Tobias
A1  - Poghossian, Arshak
A1  - Ser, Joey
A1  - Tsokolakyan, Astghik
A1  - Achtsnicht, Stefan
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Capacitive model of enzyme-modified field-effect biosensors: Impact of enzyme coverage
JF  - Sensors and Actuators B: Chemical
N2  - Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed.
KW  - Field-effect biosensor
KW  - Capacitive model
KW  - Enzyme coverage
KW  - Multianalyte detection
KW  - Penicillin
Y1  - 2024
U6  - http://dx.doi.org/10.1016/j.snb.2024.135530
SN  - 0925-4005 (Print)
SN  - 1873-3077 (Online)
N1  - Corresponding Author: Michael J. Schöning
VL  - 408
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Chaudhuri, S.
A1  - Zander, W.
A1  - Schubert, J.
A1  - Begoyan, V. K.
A1  - Buniatyan, V. V.
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Capacitively coupled electrolyte-conductivity sensor based on high-k material of barium strontium titanate
JF  - Sensors and actuators. B: Chemical
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.snb.2014.02.103
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
IS  - 198
SP  - 102
EP  - 109
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schopp, Christoph
A1  - Doll, Timo
A1  - Gräser, Ulrich
A1  - Harzheim, Thomas
A1  - Heuermann, Holger
A1  - Kling, Rainer
A1  - Marso, Michael
T1  - Capacitively Coupled High-Pressure Lamp Using Coaxial Line Networks
JF  - IEEE Transactions on Microwave Theory and Techniques
N2  - This paper describes the development of a capacitively coupled high-pressure lamp with input power between 20 and 43 W at 2.45 GHz, using a coaxial line network. Compared with other electrodeless lamp systems, no cavity has to be used and a reduction in the input power is achieved. Therefore, this lamp is an alternative to the halogen incandescent lamp for domestic lighting. To serve the demands of domestic lighting, the filling of the lamp is optimized over all other resulting requirements, such as high efficacy at low induced powers and fast startups. A workflow to develop RF-driven plasma applications is presented, which makes use of the hot S-parameter technique. Descriptions of the fitting process inside a circuit and FEM simulator are given. Results of the combined ignition and operation network from simulations and measurements are compared. An initial prototype is built and measurements of the lamp's lighting properties are presented along with an investigation of the efficacy optimizations using large signal amplitude modulation. With this lamp, an efficacy of 135 lmW -1 is achieved.
Y1  - 2016
U6  - http://dx.doi.org/10.1109/TMTT.2016.2600326
SN  - 0018-9480
VL  - 64
IS  - 10
SP  - 3363
EP  - 3368
PB  - IEEE
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Rodrigues, Raul T.
A1  - Morais, Paulo V.
A1  - Nordi, Cristina S. F.
A1  - Schöning, Michael Josef
A1  - Siqueira Jr., José R.
A1  - Caseli, Luciano
T1  - Carbon Nanotubes and Algal Polysaccharides To Enhance the Enzymatic Properties of Urease in Lipid Langmuir-Blodgett Films
JF  - Langmuir
N2  - Algal polysaccharides (extracellular polysaccharides) and carbon nanotubes (CNTs) were adsorbed on dioctadecyldimethylammonium bromide Langmuir monolayers to serve as a matrix for the incorporation of urease. The physicochemical properties of the supramolecular system as a monolayer at the air–water interface were investigated by surface pressure–area isotherms, surface potential–area isotherms, interfacial shear rheology, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to hydrophilic solid supports, quartz, mica, or capacitive electrolyte–insulator–semiconductor (EIS) devices, through the Langmuir–Blodgett (LB) technique, forming mixed films, which were investigated by quartz crystal microbalance, fluorescence spectroscopy, and field emission gun scanning electron microscopy. The enzyme activity was studied with UV–vis spectroscopy, and the feasibility of the thin film as a urea sensor was essayed in an EIS sensor device. The presence of CNT in the enzyme–lipid LB film not only tuned the catalytic activity of urease but also helped to conserve its enzyme activity. Viability as a urease sensor was demonstrated with capacitance–voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results are related to the synergism between the compounds on the active layer, leading to a surface morphology that allowed fast analyte diffusion owing to an adequate molecular accommodation, which also preserved the urease activity. This work demonstrates the feasibility of employing LB films composed of lipids, CNT, algal polysaccharides, and enzymes as EIS devices for biosensing applications.
Y1  - 2018
U6  - http://dx.doi.org/10.1021/acs.langmuir.7b04317
SN  - 1520-5827
VL  - 34
IS  - 9
SP  - 3082
EP  - 3093
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Scholl, Fabio
A1  - Morais, Paulo
A1  - Gabriel, Rayla
A1  - Schöning, Michael Josef
A1  - Siqueira, Jose Roberto, Jr.
A1  - Caseli, Luciano
T1  - Carbon nanotubes arranged as smart interfaces in lipid Langmuir-Blodgett films enhancing the enzymatic properties of penicillinase for biosensing applications
JF  - Applied Materials & Interfaces
N2  - In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir–Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air–water interface was investigated by surface pressure–area isotherms, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy. Enzyme activity was studied with UV–vis spectroscopy and the feasibility of the supramolecular device nanostructured as ultrathin films were essayed in a capacitive electrolyte–insulator–semiconductor (EIS) sensor device. The presence of CNTs in the enzyme–lipid LB film not only tuned the catalytic activity of penicillinase but also helped conserve its enzyme activity after weeks, showing increased values of activity. Viability as penicillin sensor was demonstrated with capacitance/voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results may be related not only to the nanostructured system provided by the film, but also to the synergism between the compounds on the active layer, leading to a surface morphology that allowed a fast analyte diffusion because of an adequate molecular accommodation, which also preserved the penicillinase activity. This work therefore demonstrates the feasibility of employing LB films composed of lipids, CNTs, and enzymes as EIS devices for biosensing applications.
Y1  - 2017
U6  - http://dx.doi.org/10.1021/acsami.7b08095
SN  - 1944-8252
VL  - 9
IS  - 36
SP  - 31054
EP  - 31066
PB  - ACS
CY  - Washington
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Abouzar, Maryam H.
A1  - Bäcker, Matthias
A1  - Zucolotto, Valtencir
A1  - Poghossian, Arshak
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors
JF  - physica status solidi (a) . 206 (2009), H. 3
Y1  - 2009
SN  - 1862-6319
N1  - Special Issue: Engineering of Functional Interfaces (EnFI 08)
SP  - 462
EP  - 467
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Handtke, Stefan
A1  - Volland, Sonja
A1  - Methling, Karen
A1  - Albrecht, Dirk
A1  - Becher, Dörte
A1  - Nehls, Jenny
A1  - Bongaerts, Johannes
A1  - Maurer, Karl-Heinz
A1  - Lalk, Michael
A1  - Liesegang, Heiko
A1  - Voigt, Birgit
A1  - Daniel, Rolf
A1  - Hecker, Michael
T1  - Cell physiology of the biotechnological relevant bacterium Bacillus pumilus - An omics-based approach
JF  - Journal of Biotechnology
N2  - Members of the species Bacillus pumilus get more and more in focus of the biotechnological industry as potential new production strains. Based on exoproteome analysis, B. pumilus strain Jo2, possessing a high secretion capability, was chosen for an omics-based investigation. The proteome and metabolome of B. pumilus cells growing either in minimal or complex medium was analyzed. In total, 1542 proteins were identified in growing B. pumilus cells, among them 1182 cytosolic proteins, 297 membrane and lipoproteins and 63 secreted proteins. This accounts for about 43% of the 3616 proteins encoded in the B. pumilus Jo2 genome sequence. By using GC–MS, IP-LC/MS and H NMR methods numerous metabolites were analyzed and assigned to reconstructed metabolic pathways. In the genome sequence a functional secretion system including the components of the Sec- and Tat-secretion machinery was found. Analysis of the exoproteome revealed secretion of about 70 proteins with predicted secretion signals. In addition, selected production-relevant genome features such as restriction modification systems and NRPS clusters of B. pumilus Jo2 are discussed.
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.jbiotec.2014.08.028
SN  - 1873-4863 (E-Journal); 0168-1656 (Print)
IS  - 192(A)
SP  - 204
EP  - 214
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - Cellular engineering - a challenge for engineers? / Artmann, G. M.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 449
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Kelemen, C.
A1  - Porst, Dariusz
A1  - Büldt, G.
T1  - Cellular engineering: Crash tests an menschlichen Erythrozyten geben Aufschluß über versteckte Materialeigenschaften zellulärer Proteine / Artmann, G. M. ; Kelemen, Ch. ; Porst, D. ; Büldt, G. ; Chien, Shu
JF  - Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1
Y1  - 1998
SN  - 1862-278
SP  - 446
EP  - 447
ER  - 
TY  - JOUR
A1  - Koch, Linda
A1  - Wunderlich, F. Thomas
A1  - Seibler, Jost
A1  - Könner, A. Christine
A1  - Hampel, Brigitte
A1  - Irlenbusch, Sigrid
A1  - Brabant, Georg
A1  - Kahn, C. Ronald
A1  - Schwenk, Frieder
A1  - Brüning, Jens C.
T1  - Central insulin action regulates peripheral glucose and fat metabolism in mice
JF  - The Journal of Clinical Investigation (JCI)
Y1  - 2008
U6  - http://dx.doi.org/10.1172/JCI31073
SN  - 1558-8238
VL  - 118
IS  - 6
SP  - 2132
EP  - 2147
ER  - 
TY  - JOUR
A1  - Hagemann, Hans-Jürgen
A1  - Hennings, D.
A1  - Wernicke, R.
T1  - Ceramic multilayer capacitors. Hagemann, H. J.; Hennings, D.; Wernicke, R.
JF  - Philips' technical review / Philips' Gloeilampenfabrieken. Philips' Gloeilampenfabrieken <Eindhoven>. 41 (1984)
Y1  - 1984
SN  - 0031-7926
SP  - 89
EP  - 98
ER  - 
TY  - JOUR
A1  - Prielmeier, Franz
A1  - Nagatomo, Yasushi
A1  - Frahm, Jens
T1  - Cerebral blood oxygenation in rat brain during hypoxic hypoxia. Quantitative MRI of effective transverse relaxation rates
JF  - Magnetic Resonance in Medicine. 31 (1994), H. 6
Y1  - 1994
SN  - 0740-3194
SP  - 678
EP  - 681
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Behr, M.
A1  - Arora, D.
A1  - Coronado, O.
A1  - Pasquali, M.
T1  - CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction / Behbahani, M. ; Behr, M. ; Arora, D. ; Coronado, O. ; Pasquali, M.
JF  - Artificial Organs. 30 (2006), H. 11
Y1  - 2006
SN  - 1525-1594
N1  - Abstracts 14th Congress of the International Society for Rotary Blood Pumps, Leuven, Belgium, August 31–September 2, 2006 ; S7-4
SP  - A45
EP  - A46
ER  - 
TY  - JOUR
A1  - Ayed, Anis Haj
A1  - Kusterer, Karsten
A1  - Funke, Harald
A1  - Keinz, Jan
A1  - Bohn, D.
T1  - CFD based exploration of the dry-low-NOx hydrogen micromix combustion technology at increased energy densities
JF  - Propulsion and Power Research
KW  - Micromix combustion
KW  - Hydrogen gas turbine
KW  - Hydrogen combustion
KW  - High hydrogen combustion
KW  - Dry-low-NOx (DLN) combustion
Y1  - 2017
SN  - 2212-540X
U6  - http://dx.doi.org/10.1016/j.jppr.2017.01.005
VL  - 6
IS  - 1
SP  - 15
EP  - 24
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Ayed, Anis Haj
A1  - Kusterer, Karsten
A1  - Funke, Harald
A1  - Keinz, Jan
T1  - CFD Based Improvement of the DLN Hydrogen Micromix Combustion Technology at Increased Energy Densities
JF  - American Scientific Research Journal for Engineering, Technology, and Sciences (ASRJETS)
N2  - Combined with the use of renewable energy sources for its production, Hydrogen represents a possible alternative gas turbine fuel within future low emission power generation. Due to the large difference in the physical properties of Hydrogen compared to other fuels such as natural gas, well established gas turbine combustion systems cannot be directly applied for Dry Low NOx (DLN) Hydrogen combustion. Thus, the development of DLN combustion technologies is an essential and challenging task for the future of Hydrogen fuelled gas turbines. The DLN Micromix combustion principle for hydrogen fuel has been developed to significantly reduce NOx-emissions. This combustion principle is based on cross-flow mixing of air and gaseous hydrogen which reacts in multiple miniaturized diffusion-type flames. The major advantages of this combustion principle are the inherent safety against flash-back and the low NOx-emissions due to a very short residence time of reactants in the flame region of the micro-flames. The Micromix Combustion technology has been already proven experimentally and numerically for pure Hydrogen fuel operation at different energy density levels. The aim of the present study is to analyze the influence of different geometry parameter variations on the flame structure and the NOx emission and to identify the most relevant design parameters, aiming to provide a physical understanding of the Micromix flame sensitivity to the burner design and identify further optimization potential of this innovative combustion technology while increasing its energy density and making it mature enough for real gas turbine application. The study reveals great optimization potential of the Micromix Combustion technology with respect to the DLN characteristics and gives insight into the impact of geometry modifications on flame structure and NOx emission. This allows to further increase the energy density of the Micromix burners and to integrate this technology in industrial gas turbines.
Y1  - 2016
SN  - 2313-4402
VL  - 26
IS  - 3
SP  - 290
EP  - 303
PB  - GSSRR
ER  - 
TY  - JOUR
A1  - Haag, S.
A1  - Zontar, D.
A1  - Schleupen, Josef
A1  - Müller, T.
A1  - Brecher, C.
T1  - Chain of refined perception in self-optimizing assembly of micro-optical systems
JF  - Journal of sensors and sensor systems
N2  - Today, the assembly of laser systems requires a large share of manual operations due to its complexity regarding the optimal alignment of optics. Although the feasibility of automated alignment of laser optics has been shown in research labs, the development effort for the automation of assembly does not meet economic requirements – especially for low-volume laser production. This paper presents a model-based and sensor-integrated assembly execution approach for flexible assembly cells consisting of a macro-positioner covering a large workspace and a compact micromanipulator with camera attached to the positioner. In order to make full use of available models from computer-aided design (CAD) and optical simulation, sensor systems at different levels of accuracy are used for matching perceived information with model data. This approach is named "chain of refined perception", and it allows for automated planning of complex assembly tasks along all major phases of assembly such as collision-free path planning, part feeding, and active and passive alignment. The focus of the paper is put on the in-process image-based metrology and information extraction used for identifying and calibrating local coordinate systems as well as the exploitation of that information for a part feeding process for micro-optics. Results will be presented regarding the processes of automated calibration of the robot camera as well as the local coordinate systems of part feeding area and robot base.
Y1  - 2014
U6  - http://dx.doi.org/10.5194/jsss-3-87-2014
SN  - 2194-878X
VL  - 3
IS  - 1
SP  - 87
EP  - 95
PB  - Copernicus Publ.
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Schubert, J.
A1  - Schöning, Michael Josef
A1  - Schmidt, C.
A1  - Siegert, M.
A1  - Mesters, S.
A1  - Zander, W.
A1  - Kordos, P.
A1  - Lüth, H.
A1  - Legin, A.
A1  - Mourzina, Y. G.
A1  - Seleznev, B.
A1  - Vlasov, Y. G.
T1  - Chalcogenide-based thin film sensors prepared by pulsed laser deposition technique
JF  - Applied Physics A. 69, (1999), H. Supplement 1
Y1  - 1999
SN  - 0947-8396
U6  - http://dx.doi.org/10.1007/s003390051534
SP  - 803
EP  - 805
ER  - 
TY  - JOUR
A1  - Serror, Martin
A1  - Hack, Sacha
A1  - Henze, Martin
A1  - Schuba, Marko
A1  - Wehrle, Klaus
T1  - Challenges and Opportunities in Securing the Industrial Internet of Things
JF  - IEEE Transactions on Industrial Informatics
Y1  - 2021
U6  - http://dx.doi.org/10.1109/TII.2020.3023507
SN  - 1941-0050
VL  - 17
IS  - 5
SP  - 2985
EP  - 2996
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Hoffstadt, Kevin
A1  - Pohen, Gino D.
A1  - Dicke, Max D.
A1  - Paulsen, Svea
A1  - Krafft, Simone
A1  - Zang, Joachim W.
A1  - Fonseca-Zang, Warde A. da
A1  - Leite, Athaydes
A1  - Kuperjans, Isabel
T1  - Challenges and prospects of biogas from energy cane as supplement to bioethanol production
JF  - Agronomy
N2  - Innovative breeds of sugar cane yield up to 2.5 times as much organic matter as conventional breeds, resulting in a great potential for biogas production. The use of biogas production as a complementary solution to conventional and second-generation ethanol production in Brazil may increase the energy produced per hectare in the sugarcane sector. Herein, it was demonstrated that through ensiling, energy cane can be conserved for six months; the stored cane can then be fed into a continuous biogas process. This approach is necessary to achieve year-round biogas production at an industrial scale. Batch tests revealed specific biogas potentials between 400 and 600 LN/kgVS for both the ensiled and non-ensiled energy cane, and the specific biogas potential of a continuous biogas process fed with ensiled energy cane was in the same range. Peak biogas losses through ensiling of up to 27% after six months were observed. Finally, compared with second-generation ethanol production using energy cane, the results indicated that biogas production from energy cane may lead to higher energy yields per hectare, with an average energy yield of up to 162 MWh/ha. Finally, the Farm²CBG concept is introduced, showing an approach for decentralized biogas production.
Y1  - 2020
U6  - http://dx.doi.org/10.3390/agronomy10060821
SN  - 2073-4395
VL  - 10
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Vögele, Stefan
A1  - Grajewski, Matthias
A1  - Govorukha, Kristina
A1  - Rübbelke, Dirk
T1  - Challenges for the European steel industry: Analysis, possible consequences and impacts on sustainable development
JF  - Applied Energy
N2  - The steel industry in the European Union (EU), important for the economy as a whole, faces various challenges. These are inter alia volatile prices for relevant input factors, uncertainties concerning the regulation of CO₂-emissions and market shocks caused by the recently introduced additional import duties in the US, which is an important sales market. We examine primary and secondary effects of these challenges on the steel industry in the EU and their impacts on European and global level. Developing and using a suitable meta-model, we analyze the competitiveness of key steel producing countries with respect to floor prices depending on selected cost factors and draw conclusions on the impacts in the trade of steel on emissions, energy demand, on the involvement of developing countries in the value chain as well on the need for innovations to avoid relocations of production. Hence, our study contributes to the assessment of sustainable industrial development, which is aimed by the Sustainability Development Goal “Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation countries”. By applying information on country-specific Human Development Indexes (reflecting aspects of life expectancy, education, and per capita income), we show that relocating energy-intensive industries from the EU may not only increase global energy demand and CO₂-emissions, but may also be to the disadvantage of developing countries.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.apenergy.2020.114633
SN  - 0306-2619
VL  - 264
IS  - Article number: 114633
PB  - Elsevier
CY  - Amsterdam
ER  -