TY - JOUR A1 - Quittmann, Oliver J. A1 - Meskemper, Joshua A1 - Albracht, Kirsten A1 - Abel, Thomas A1 - Foitschik, Tina A1 - Strüder, Heiko K. T1 - Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs JF - Journal of Electromyography and Kinesiology N2 - Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA. Y1 - 2020 U6 - https://doi.org/10.1016/j.jelekin.2020.102402 SN - 1050-6411 VL - 51 IS - Article 102402 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Karschuck, T. L. A1 - Filipov, Y. A1 - Bollella, P. A1 - Schöning, Michael Josef A1 - Katz, E. T1 - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction JF - International Journal of Unconventional Computing N2 - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions. Y1 - 2019 SN - 1548-7199 VL - 14 IS - 3-4 SP - 235 EP - 242 PB - Old City Publishing CY - Philadelphia ER - TY - JOUR A1 - Pawelke, Siegfried T1 - Note on Jackson and Bernstein type approximation theorems in the case of approximation by algebraic polynomial in the spaces L and C JF - Studia Scientiarum Mathematicarum Hungarica. 36 (2000), H. 3-4 Y1 - 2000 SN - 0081-6906 SP - 353 EP - 358 ER - TY - JOUR A1 - Ringers, Christa A1 - Bialonski, Stephan A1 - Ege, Mert A1 - Solovev, Anton A1 - Hansen, Jan Niklas A1 - Jeong, Inyoung A1 - Friedrich, Benjamin M. A1 - Jurisch-Yaksi, Nathalie T1 - Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia JF - eLife N2 - Motile cilia are hair-like cell extensions that beat periodically to generate fluid flow along various epithelial tissues within the body. In dense multiciliated carpets, cilia were shown to exhibit a remarkable coordination of their beat in the form of traveling metachronal waves, a phenomenon which supposedly enhances fluid transport. Yet, how cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine experiments, novel analysis tools, and theory to address this knowledge gap. To investigate collective dynamics of cilia, we studied zebrafish multiciliated epithelia in the nose and the brain. We focused mainly on the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Even though synchronization is local only, we observed global patterns of traveling metachronal waves across the zebrafish multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right noses, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions, i.e., cilia colliding with each other, and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment coincide and generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping. Y1 - 2023 U6 - https://doi.org/10.7554/eLife.77701 SN - 2050-084X VL - 12 PB - eLife Sciences Publications ER - TY - JOUR A1 - Schöning, Michael Josef T1 - Novel approaches to design siliconbased field-effect sensors JF - Electrochemical Microsystem Technologies, New Trends in Electrochemistry Vol. 2 Y1 - 2002 SP - 384 EP - 408 PB - Taylor & Francis CY - London New York ER - TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, Ko-ichiro A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging JF - Procedia Engineering N2 - Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach of read out in a light-addressable potentiometric sensor (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device which allows fast and flexible generation of light patterns. With the help of these light patterns the sensor surface of the LAPS device can be read out sequentially in a raster like scheme (scanning LAPS). The DLP approach has several advantages compared to conventional scanning LAPS set-ups, e.g., the spot size, the shape and the intensity of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of measurement. Y1 - 2010 U6 - https://doi.org/10.1016/j.proeng.2010.09.161 SN - 1877-7058 N1 - Eurosensor XXIV Conference, 5-8 September 2010, Linz, Austria VL - 5 SP - 520 EP - 523 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Poghossian, Arshak A1 - Berndsen, Lars A1 - Lüth, Hans A1 - Schöning, Michael Josef T1 - Novel concepts for flow-rate and flow-direction determination by means of pH-sensitive ISFETs JF - Proceedings of SPIE. 4560 (2001) Y1 - 2001 SP - 19 EP - 27 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Lüth, H. T1 - Novel concepts for silicon-based biosensors JF - Physica Status Solidi (A) (2001) Y1 - 2001 SN - 0031-8965 SP - 65 EP - 77 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Malkoc, Ü. A1 - Thust, M. A1 - Steffen, A. A1 - Kordos, P. A1 - Lüth, H. T1 - Novel electrochemical sensors with structured and porous semiconductor/insulator capacitors JF - Sensors and Actuators B. 65 (2000), H. 1-3 Y1 - 2000 SN - 0925-4005 SP - 288 EP - 290 ER - TY - JOUR A1 - Schöning, Michael Josef A1 - Malkoc, Ü. A1 - Thust, M. A1 - Steffen, A. A1 - Kordos, P. A1 - Lüth, H. T1 - Novel electrochemical sensors with structured and porous semiconductor/insulator capacitors JF - Proceedings of the Seventh International Meeting on Chemical Sensors : 27 - 30 July, 1998, Beijing, P. R. China / ed. Zhi-Gang Zhou Y1 - 1998 N1 - International Meeting on Chemical Sensors ; (7, 1998, Beijing) ; International Meeting on Chemical Sensors (IMCS) ; (7 : ; 1998.07.27-30 : ; Beijing) SP - 885 EP - 887 PB - Elsevier CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Guo, Yuanyuan A1 - Seki, Kosuke A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution JF - Applied physics express : APEX N2 - A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) is proposed to achieve a higher spatial resolution of chemical images. The proposed method employs a combined light source that consists of a modulated light probe, which generates the alternating photocurrent signal, and a ring of constant illumination surrounding it. The constant illumination generates a sheath of carriers with increased concentration which suppresses the spread of photocarriers by enhanced recombination. A device simulation was carried out to verify the effect of constant illumination on the spatial resolution, which demonstrated that a higher spatial resolution can be obtained. Y1 - 2014 U6 - https://doi.org/10.7567/APEX.7.067301 SN - 1882-0786 (E-Journa); 1882-0778 (Print) VL - 7 IS - 6 SP - 067301-4 PB - IOP CY - Bristol ER - TY - JOUR A1 - Iken, Heiko A1 - Kirsanov, D. A1 - Legin, A. A1 - Schöning, Michael Josef T1 - Novel Thin-Film Polymeric Materials for the Detection of Heavy Metals JF - Procedia Engineering N2 - A variety of transition metals, e.g., copper, zinc, cadmium, lead, etc. are widely used in industry as components for wires, coatings, alloys, batteries, paints and so on. The inevitable presence of transition metals in industrial processes implies the ambition of developing a proper analytical technique for their adequate monitoring. Most of these elements, especially lead and cadmium, are acutely toxic for biological organisms. Quantitative determination of these metals at low activity levels in different environmental and industrial samples is therefore a vital task. A promising approach to achieve an at-side or on-line monitoring on a miniaturized and cost efficient way is the combination of a common potentiometric sensor array with heavy metal-sensitive thin-film materials, like chalcogenide glasses and polymeric materials, respectively. Y1 - 2012 U6 - https://doi.org/10.1016/j.proeng.2012.09.148 SN - 1877-7058 N1 - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012" IS - 47 SP - 322 EP - 325 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Köster, Michael A1 - Turek, Stefam T1 - Numerical analysis and implementational aspects of a new multilevel grid deformation method JF - Applied Numerical Mathematics N2 - Recently, we introduced and mathematically analysed a new method for grid deformation (Grajewski et al., 2009) [15] we call basic deformation method (BDM) here. It generalises the method proposed by Liao et al. (Bochev et al., 1996; Cai et al., 2004; Liao and Anderson, 1992) [4], [6], [20]. In this article, we employ the BDM as core of a new multilevel deformation method (MDM) which leads to vast improvements regarding robustness, accuracy and speed. We achieve this by splitting up the deformation process in a sequence of easier subproblems and by exploiting grid hierarchy. Being of optimal asymptotic complexity, we experience speed-ups up to a factor of 15 in our test cases compared to the BDM. This gives our MDM the potential for tackling large grids and time-dependent problems, where possibly the grid must be dynamically deformed once per time step according to the user's needs. Moreover, we elaborate on implementational aspects, in particular efficient grid searching, which is a key ingredient of the BDM. Y1 - 2010 U6 - https://doi.org/10.1016/j.apnum.2010.03.017 SN - 0168-9274 VL - 60 IS - 8 SP - 767 EP - 781 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Hron, Jaroslav A1 - Turek, Stefan T1 - Numerical analysis for a new non-conforming linear finite element on quadrilaterals JF - Journal of Computational and Applied Mathematics Y1 - 2006 U6 - https://doi.org/10.1016/j.cam.2005.05.024 SN - 0377-0427 VL - 193 IS - 1 SP - 38 EP - 50 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Mai, A. A1 - Waluga, C. A1 - Bergmann, B. A1 - Tran, L. A1 - Vonderstein, K. A1 - Behr, M. A1 - Mottaghy, K. T1 - Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions JF - Acta Physiologica Y1 - 2010 SN - 1748-1716 N1 - Joint Congress of the Scandinavian and German Physiological Societies, Copenhagen, Denmark, March 27-30, 2010 VL - 198 IS - Supplement 677 SP - 185 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Probst, M. A1 - Mai, A. A1 - Behr, M. A1 - Tran, L. A1 - Vonderstein, K. A1 - Mottaghy, K. T1 - Numerical Prediction of Blood Damage in Biomedical Devices Y1 - 2010 N1 - Posterpresentation ; Biomedica Congress, Aachen, March 17-18, 2010 ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Tran, L. A1 - Jockenhövel, S. A1 - Behr, M. A1 - Mottaghy, K. T1 - Numerical prediction of thrombocyte reactions for application to a vascular flow model JF - British Journal of Surgery Y1 - 2011 SN - 1365-2168 N1 - 46th Congress of the European Society for Surgical Research, Aachen, Germany, 25-28 May 2011 ; ESSR Abstracts 2011 ; Oral Sessions OP10-5 VL - 98 IS - S5 SP - S17 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Lieder, R. M. A1 - Didelez, J. P. A1 - Beuscher, H. T1 - Observation of a New Isomer in ²¹² Po JF - Annual report 1978 / Kernforschungsanlage Jülich Institut für Kernphysik / Hrsg.: A. Fässler. - Y1 - 1979 N1 - Spezielle Berichte der Kernforschungsanlage Jülich ; 36 SP - 38 PB - Kernforschungsanlage CY - Jülich ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Lieder, R. M. A1 - Didelez, J. P. A1 - Beuscher, H. T1 - Observation of a New Isomer in ²¹² Po JF - Physical review letters Y1 - 1978 U6 - https://doi.org/10.1103/PhysRevLett.41.742 SN - 0031-9007 VL - 41 IS - 11 SP - 742 EP - 745 PB - American Physical Society CY - Ridge, NY ER - TY - JOUR A1 - Müller-Veggian, Mattea A1 - Neskakis, A. A1 - Lieder, R. M. T1 - Observation of rotation-aligned bands in the odd-odd nuclei ¹⁹⁰,¹⁹²,¹⁹⁴ Au JF - Physics letters / B. 80 (1979), H. 3 Y1 - 1979 SN - 0031-9163 N1 - 2. ISSN: 0370-2693 SP - 194 EP - 197 ER -